functional foods linking nutrients to disease. cameron...enhance nitric oxide synthesis 37 . 42 ....

42
Functional Foods – linking nutrients to disease. Professor David Cameron-Smith Chair in Nutrition Liggins Institute University of Auckland New Zealand

Upload: others

Post on 11-Jul-2020

4 views

Category:

Documents


0 download

TRANSCRIPT

Page 1: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki

Functional Foods – linking nutrients to disease.

Professor David Cameron-Smith

Chair in Nutrition

Liggins Institute

University of Auckland

New Zealand

Page 2: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki

Functional/Dysfunctional

• Will the real functional food stand up?

• Dysfunctional food

–Too much, too often

• Fats - form, function and physiology

• Sweetness and light

• The ORIGINAL SUPERFOODS

• Antioxidants – yes/no

• Why eat rabbit food?

Page 3: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki

3

Page 4: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki

1972

4

Page 5: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki

Atherosclerosis

5

Page 6: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki

Breakfast Lunch Dinner 4:00am Breakfast 0:00am

Postprandial Postabsorptive Fasting

Monier L. Eur. J. Clin. Invest. 30(suppl 2): 3-11, 2000

How we spend our day….

6

Page 7: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki

We eat…often

7

Page 8: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki
Page 9: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki

The emerging role of Inflammation

9

Page 10: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki

Dietary Fats and CHD

Page 11: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki

The REAL Mediterranean Diet

Page 12: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki

To make it tasty……

Page 13: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki

Trans – Fatty Acids

13

Page 14: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki

Industrially generated trans FA

14

Mozaffarian et al, N. Engl. J. Med. 354: 1601-1613, 2006

Page 15: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki

15

Polyunsaturates

Simopoulos, AP. Am. J. Clin. Nutr. 70(suppl):560S-9S, Data from Eaton SB & Connor W

Note:

High n-6 to n-3 ratio

Page 16: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki

16 Din et al. BMJ 2004; 328: 30

Eicosanoid Products

Page 17: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki

Omega-3 fatty acids

17

Page 18: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki

Resolution of Inflammation

Ru-Rong J et al. Trends in Neurosci. 2011; 34(11; 599-609)

Page 19: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki

SUPER foods and drinks

Page 20: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki

Sucrose = glucose + fructose

Page 21: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki

Satiety

Page 22: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki
Page 23: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki
Page 24: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki

Back to Superfoods

Page 25: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki
Page 26: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki
Page 27: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki
Page 28: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki
Page 29: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki
Page 30: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki

Prebiotics and Health

Page 31: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki
Page 32: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki

Plant Secondary Metabolites

Page 33: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki
Page 34: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki
Page 35: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki
Page 36: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki
Page 37: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki

Enhance Nitric Oxide Synthesis

37

Page 38: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki
Page 39: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki
Page 40: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki
Page 41: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki
Page 42: Functional Foods linking nutrients to disease. Cameron...Enhance Nitric Oxide Synthesis 37 . 42 . LIGGINS INSTITUTE THE UNIVERSITY OF AUCKLAND NEW ZEALAND Te Whare Wananga o Tamaki

42