future trends in blood and marrow transplantation in hct... · marrow transplantation sergio...
TRANSCRIPT
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Future Trends in Blood and Marrow Transplantation
Sergio Giralt, MDMelvin Berlin Family Chair in Myeloma ResearchProfessor of MedicineWeill Cornell College of Medicine Chief, Adult BMT Service Memorial Sloan Kettering Cancer Center
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Agenda
• Hematopoietic Cell Transplantation– Historical Perspective– Current status
• Competing technologies• Future trends• Summary
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HCT Historical Perspective
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Leon Jacobson et al. Effect of spleen protection on mortality following x-irradiation. J Lab Clin Med 1949;34:1538-43.
August 1949 Russians succeed in developing a nuclear weapon
Egon Lorenz 1892-1954Lorenz E, et al: Modification of irradiation injury in mice and guinea pigs by bone marrow injections. JNatl Cancer Inst 12:197-201, 1951
John Freeman Loutittogether with David BarnesDemonstrate the existence ofA graft vs leukemia effect
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Hematopoiesis
Stem Cells
Granulocytes
Monocytes
Eosinophils
Basophils
Erythrocytes
Megakaryocytes
Platelets
T-lymphocytes
B-lymphocytes
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Course in Case 6.
Thomas ED et al. N Engl J Med 1957;257:491‐496.
Dr. E Donnell Thomas receives Nobel Prize in 1990
…the bone marrow was obtained from a pacient with blood type 0, C(+) who had died from a brain hemorrhage. The ribs were removed under sterile conditions between 1 hour and 30 minutes and 2 hours and 5 minutes after death. The bone marrow was extracted from the ribs and suspended in tissue culture media…
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Allogeneic TransplantationFirst Registry Report
Dr. Mortimer Bortin Founder of the International Bone Marrow Transplant Registry (IBMTR)
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Tumors that exhibit dose response effect to chemoLeukemiaLymphomaTesticular CancerNeuroblastomaBreast Cancer
Tumors that don’tLungKidneyColon
RATIONALE FORHIGH-DOSE THERAPY
ESH0 0 2.p pt
Dose
Cur
es
100%
Lethal bonemarrow toxicity
Lethal toxicityto other organs
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Development of central venous access catheters Hickman –Boviac - Hohn
Jean Dausett, Jan van Rood y Paul Terasaki. HLA pioneers in the 1970’sDevelopment of Laminar air flow rooms, new antibiotics, antivirals, antifungals1970-present
Stanley Dudrickdevelops TPN in the 1970’s
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AbstractTreatment of a 5-month-old male with sex-linked lymphopenic immunological deficiency utilising immunologically competent cells from peripheral blood buffy coat and bone-marrow of a sibling donor resulted in reconstitution of both cellular and humoral immunity. Fatal graft-versus-host disease was circumvented by using donor cells which were histo compatible with the patient's cells with respect to the HL-A locus, as determined by both mixed lymphocyte cultures and lymphocytotoxic assay. A mild graft-versus-host reaction appeared at 8 days post-implantation but resolved spontaneously. Biopsies of rectal mucosa and skin indicate a continuing round-cell infiltration of host tissue 2 months post-implantation; the patient, however, remains clinically well
Robert Good MD, PhD : first succesful HCT in the world in a patient with SCID
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TO S00 38. ppt
PROBABILITY OF RELAPSE AFTERHLA-IDENTICAL SIBLING TRANSPLANTS
FOR EARLY LEUKEMIA
0 2 4 61 3 50
20
40
60
80
100
PRO
BAB
ILIT
Y O
F RE
LAPS
E, %
YEARS
T Depletion (N=401)
Twins (N=70)
No GVHD (N=433)
AGVHD Only (N=738)
AGVHD + CGVHD (N=485)
CGVHD Only (N=127)
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Timeline Showing Numbers of Bone Marrow Transplantations and Advances in the Field, 1957–2006.
Appelbaum FR. N Engl J Med 2007;357:1472‐1475.
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INDICATIONS FOR BLOOD AND MARROW TRANSPLANTATION IN NORTH AMERICA
2002
TRA
NSP
LAN
TS
4,500
0
500
1,000
1,500
2,000
Allogeneic (Total N = 7,200)Autologous (Total N = 10,500)
2,500
3,000
4,000
3,500
BreastCancer
NHLMultipleMyeloma
AML ALL CMLMDS / Other
Leukemia
CLL OtherCancerNeuroblastoma
HodgkinDisease
Non-MalignantDisease
7
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HCT Current Status
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Worldwide Network for Blood and Marrow Transplantation
34 550 HSCT’s 2006 – 2008Transplant rates allogeneic HSCT: acute leukemias
TR per 10 mil Pop.: Acute Leukemias:
Allo HSCT 2006-2008
(average N. HSCT over 3 year period)
0 or no report< 2525.1 – 5050.1 – 100> 100
Hong KongSingapore
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Five Phases of Transplant
Complications:
BMT Process:
Supportive Therapy:
TIME LINE -12 0 0.5 2 6 >12 months
MarrowFailurePhase 2
Low Count Phase
Phase 3 Early
Recovery3-4 weks post SCT
Phase 4: Early Convalescence
1-12 months
High-dose myeloablative
therapyPhase I Chemo
Phase
Disease State:
Antibiotics
Nutrition
Antiemetics
Growth factors
Red cell transfusionsPlatelet transfusionsChemo XRT
Secondary tumors, cataracts, endocrine changes, QoL
Acute and/or chronic GvHDViral infections
CMV, VZV, PCP, IP
Bacterial infections
HSV, mucositis VOD
Stem cellinfusion
Marrow function
Immune function
Phase 5: Late Convalescence
>12 months
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Traditional Inpatient HCT in Protective Environment
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Modern BMT Inpatient Unit
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Outpatient Stem Cell TransplantationPatients live in an extended living facility proximal to the hospital (30 minutes)
Come back and forth daily to receive care
Evaluation healthcare professional
Laboratory assessmentIntervention (fluids,
electrolytes and transfusion)
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Percent Need Met(Actual / Calculated Demand)
0-24.9%25-49.9%50-74.9%75-100%>100%
© 2011 National Marrow Donor ProgramNot for disclosure/distribution/duplication without permission
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847
32464264
957
2710
4820
2044
9618
22357
1369
6638
17839
0
5000
10000
15000
20000
25000
18‐49 50‐64 65+
Black man
Black women
White man
White women
Number of newly diagnosed cases Number of first AHPCT
212 616 228237 592 1651025
4081
1903643
2850
1239
0
5000
10000
15000
20000
25000
18‐49 50‐64 65+
Black men
Black women
White men
White women
0
0.1
0.2
0.3
0.4
0.5
0.6
40 45 50 55 60 65 70 75 80 85 90
black men
black women
white men
white women
AHPCT “utilization rate”
Costa et al.
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Center Size Categories• Based on 2010 total HCT volume (N=84 centers)
25
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Effect of Race on Utilization of HCTCaucasian‐ vs. African‐Americans
Overall Autologous HLA-identical UnrelatedHCT HCT Sib HCT Donor HCT
P<0.0001
1.351.451.40
Od
ds
Rat
io
0.00
1.00
1.50
2.00
2.50
0.50
P<0.0001
1.191.301.24
P<0.0001
1.46
1.741.59
P<0.0001
1.75
2.33
2.02
Relative risk95% CI
Joshua TV et al, Cancer; 2010
Likelihood of undergoing HCT 1997‐2002; CIBMTR & SEER data
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HCT Current StatusIncreasing Access/Breaking BarriersAge
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Contribution of Allografting to Treatment of Cancer
ESTIMATED NUMBERS OF POTENTIAL TRANSPLANTCANDIDATES vs TRANSPLANT RECIPIENTS IN U.S.
0
10k
20k
30k
40k
50k
NUM
BER
S IN
THO
USA
NDS Allografts
Autografts
NHL
57,000
13,700
4,700 3,600
9,200 7,200
60k
MM AML HD CML ALL
<65
ESH0 0 6.p pt
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Conditioning Regimen Effects
conditioning regimen spectrum
High Intensity
Low Intensity
- Increase immediate anti-tumor effect
- Increase toxicity
- Rely on later graft versus disease effect
-Decreased regimen relatedtoxicity
Number of candidates for HCT
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Allografting an Aging PopulationLessons Learned from AML/MDSAllografting an Aging PopulationLessons Learned from AML/MDS
• Should there be an age limit for allografting?
• How old is too old? • Who should be considered?
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SUM12_26.ppt
Trends in Transplantsby Type and Recipient Age*
2001-2010
* Transplants for AML, ALL, NHL, Hodgkin Disease, Multiple Myeloma Slide 6
Tran
spla
nts
, %
Allogeneic Transplants Autologous Transplants
0
20
40
60
80
100
2001-2005 2006-2010 2001-2005 2006-2010
<=20 yrs21-40 yrs41-50 yrs51-60 yrs>60 yrs
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Future Trends
• 1. HCT will be used increasingly more frequently in older patients– Stress on system– Need for comprehensive rehabilitation – QOL and functional performance will become increasingly important
outcomes
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Overcoming BarriersIncreasing Donor Pool
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Clinical Problem: Finding a Donor for Allogeneic Transplantation for all Patients
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Access to HCT – Donor Availability
• Estey et al. Blood 2007• 2001‐2003• 114 AML/MDS patients in
CR 1• 15 underwent allo HCT in
CR1– Donor identified in 59% of
patients– No donor most common
stated reason for not proceeding to HCT
• Mawad et al JCO 2013• 2008 – 2011• 137 AML patients in CR1• 79 (57%) underwent HCT.• Reasons for not
proceeding to HCT .– Early relapse (31%)– Poor performance status
(21%)– Financial and psychosocial
issues (21%).
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7/8 and 8/8 Allele, Available‐Match Rates in the US Adult Donor Registry
00.10.20.30.40.50.60.70.80.9
1
AA
FA
AFB
C
ARB
S
CA
MB
AI
ND
I FI
LII
HAW
I JA
PI
KO
RI
NC
HI
SC
SE
AI
VIE
T M
EN
AFC
EU
RC
AU
C
AR
HIS
M
SW
HIS
S
CA
HIS
A
ISC
A
LAN
AM
AM
IND
C
AR
IBI
8 of 8 7 of 8
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Adult Cord Match Rates in the Cord Blood Registry, Cell Dose ≥2.5/Kg
38
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Post‐Transplant Cyclophosphamide A Disruptive Technology
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0
200
400
600
800
1000
2010 2011 2012 2013
Mism unrelated
Haploident
Single Cord
Double Cord
Use of alternative donor sources for HCT
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Drafted in 2015!!
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Future Trends• 1. HCT will be used increasingly more frequently in older patients– Stress on system– Need for comprehensive rehabilitation – QOL and functional performance will become increasingly important outcomes
• 2. HCT will be used increasingly with alternative donors, particularly in developing countries with post transplant cyclophosphamide.
• Head to head comparisons between donor sources will be needed to determine patient and disease specific donor selection algorithms.
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Overcoming BarriersPatient advocacy
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What if you remove insurance barriers? HCT for MDS over age 65 and CMS coverage
45
0
50
100
150
200
250
300
2009 2010 2011 2012 2013
RelatedUnrelated
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The Referral Bias as a Barrier
The Myeloma Example
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847
32464264
957
2710
4820
2044
9618
22357
1369
6638
17839
0
5000
10000
15000
20000
25000
18‐49 50‐64 65+
Black man
Black women
White man
White women
Number of newly diagnosed cases Number of first AHPCT
212 616 228237 592 1651025
4081
1903643
2850
1239
0
5000
10000
15000
20000
25000
18‐49 50‐64 65+
Black men
Black women
White men
White women
0
0.1
0.2
0.3
0.4
0.5
0.6
40 45 50 55 60 65 70 75 80 85 90
black men
black women
white men
white women
AHPCT “utilization rate”
Costa et al.
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More than a third of myeloma patients are not receptive to HCT as frontline treatment
…and 10‐15% are never offered the procedure… the perception of many patients and physicians is that the procedure is dangerous, or toxic, or limited to younger patients.
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Questions
• Is the HCT message being delivered to patients accurate?
• Is the HCT message being delivered to patients in an optimal manner?
• Would patients be more receptive to HCT if the message was delivered by an HCT expert?
• Would patients be more receptive to HCT if the message was delivered in a uniform way?
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Can we develop effective strategies that reduce symptom burden?
%
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MSKCC Program to reduce post HCT symptom burden
Total Symptom Burden
Treatment Experience
Host Factors
Mood
Education
Comorbid Conditions
Genetic Predisposition
Treatment Factors
Drug Specific Toxicities
Dose Intensity
Inflammatory Cytokines
Preventive Factors
Anti‐nausea meds
Pain Control
Supportive Care
Environmental Factors
Treatment Environment
Team Approach
Outpatient SCTHomebound SCT
Predictors of Severe Symptom Burden
PK Directed Melphalan TherapyNew Melphalan formulations
AcupunctureDeng et al.IL6 BlockadeKosuri et al
Light Therapy
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Is there anything we can do about this?
Importance of Community-Transplant Center Relationships
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Case 1
• 49 y/o man with diploid cytogenetics AML s/p induction and re‐induction chemo with cytarabine and idarubicin still pancytopenic
• Latest marrow – MDS no overt leukemia• Primary induction failure, with 9% blast and marrow consistent with prior
MDS. Diploid cytogenetics. 2 % circulating blasts• Still pancytopenic
– Good performance status KPS 80– Rectal fistula/abscess– No other comorbidities (Prostate hypertrophy and prior orthopedic
surgeries– CT Chest normal– CT Sinus normal
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What Next
• If patient had been seen by the BMT Service upfront he would have had a donor identified and could proceed straight to HCT.
• Otherwise he will need continued treatment until a cell source is identified which could take 4‐6 weeks.
• Does it matter?
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Increasing AccessShared care model in HCT
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Traditional Care Model for HCT for Patients in the CommunityAML
DiagnosisDisease risk assessmentInduction strategyAssessment of responsePatient & Family Disease education
HCT eligibility assessmentHLA TypingDonor SearchingPatient and Family HCT Education
HCT Center / Team
Performs most pre HCT testing
Conditioning and HCT
Post HCT care for 3‐4 months if no complications
Frequent follow up more if complications
Communication with Community Oncologist sporadic
HCT Specialist in Transplant Center
Risk assessmentHCT eligibility assessmentAssessment of responseHLA TypingDonor SearchingPatient and Family HCT Education
Proceed to HCT
Community Oncologist
Refer for HCT Assessment
Return home to community oncologist
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PROS & CONS OF TRADITIONAL MODEL
PROS
• Minimizes number of providers seeing patients at early points of a difficult disease process
• Maintains local control• Historical precedence• Reimbursement issues
clearly delineated
CONS• Many times delays the search and
procurement process• Not conducive to rapid adoption of
a HCT strategy• Maintains the HCT and community
oncologist as separate – HCT expert only establishes a
relationship late in course of disease– HCT team only releases patient back
to community when they feel comfortable that medical events are unlikely to happen
• Non HCT expert delivering HCT specific content and making HCT relevant decisions
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Shared Care Model for HCT for Patients in the CommunityAML
DiagnosisDisease risk assessmentInduction strategyAssessment of responsePatient & Family Disease educationHCT eligibility assessmentHLA TypingDonor SearchingPatient and Family HCT EducationPre HCT work up
HCT Center / Team
Performs most pre HCT testing
Conditioning and HCT
Post HCT care for 3‐4 months if no complications
Frequent follow up more if complications
Communication with Community Oncologist sporadic
HCT Specialist in Transplant Center
Proceed to HCT
Community Oncologist
Refer for HCT Assessment
Return home to community oncologist
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PROS & CONS OF SHARED CARE MODEL
PROS• Expedites search and procurement
process even for patients in whom HCT is not considered frontline treatment option
• Allows HCT team to meet the patient early and become a member of the local treatment team.
• HCT expertise delivered locally through local or HCT Center nurse navigator or both
• Facilitates transition back and forth from community to HCT center
• Brings HCT expertise into the community
CONS• Another resource needs to be
developed. Local and Transplant Center HCT Nurse Navigator
• “More cooks in the kitchen”• Telemedicine and communication
tools need to be developed.• Patient and physician buy in is key.• Reimbursement issues need to be
figured out • It has never been done by us
before, although successful shared care models do exist (Canada).
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Homebound Stem Cell Transplantation
• Delivery of all or part of stem cell transplant care within the patients home or “home like environment”
• Swedish and Spanish Experience demonstrate it is feasible and effective
• How to implement in our environment?
• What research agenda can we build around it?
• What are the barriers?
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New challenges for HCT
• Competing technologies– CAR T cells– Checkpoint blockade– Targeted therapies
• Ibrutinib• Continued perception that therapy is dangerous, complicated and very
toxic• Access to HCT Centers
– Healthcare economics– Financial viability– Workforce issues
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Competing technologiesImmuno-therapy
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J Clin Invest 2013;123(7):2756
Immune Surveillance
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• Powerful: Attacks the cancer systemically
• Specific: Trains the immune system to recognize & target only
cancer cells
• Memory: Capacity for memory means durability of
protection
• Universal: Treatment approach applicable to nearly all
cancers
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CAR Modified T Cells as Cancer Therapy
Source: mskcc.org
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• HLA‐independent antigen recognition, therefore universal application
• Active in both CD4+ and CD8+T cells• Target antigens include proteins, carbohydrates and
glycolipids • Rapid generation of tumor specific T cells • Minimal risk of GvHD• A living drug• Additional modification capability
Advantages of CAR T cell therapy
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67
Clinical Efficacy of CD19 CAR T Cells in R/R ALLT Cell Product Age, med
(range)No. of Pts.
T Cell Dose CR/MRD-CR
Survival
19-28z(JCAR015-MSK)*
45 (22-74) 39 1-3x106 CAR T cells/kg
87/70% All cohorts:Med OS: 8.5 mos6m OS: 59% (39-74)
MRD-CR cohorts:Med. OS: 10.8 mos6m OS: 75% (50-89)
19-4-1BBz(CTL019-UPenn)*
N/A 12 4x107 - 1x109
CAR T cells89 N/A
19-4-1BBz(JCAR017-FHRC)*
N/A 20 2x105-107
CAR T cells/kg83 N/A
19-4-1BBz(CTL019-CHOP)
10 (5-22) 30 ~3x106 CAR T cells/kg
90/77% 6m EFS:63% (47-84)6m OS: 78% (63-95)
19-28z(KTE-C19-NCI)
14 (5-27) 20 1-3x106 CAR T cells/kg
70/60% All cohorts:6m OS: ~65%
MRD-CR cohorts: 6m RFS: ~80%
Adults
Peds
Park J at al. ASCO Annual Meeting 2015; Frey N et al. ASH Annual Meeting 2014; Cameron et al. ASCO Annual Meeting 2015; Maude S et al. NEJM 2014; Lee D et al. Lancet Oncology 2014.
J. Park EBMT 05 April 2016: CAR T cells in hematologic malignancies
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68
Adverse Events
• Cytokine release syndrome (CRS)– Fever – Hypotension – Respiratory insufficiency
• Neurological changes – Delirium– Global encephalopathy – Aphasia – Seizure-like activities/seizure
J. Park EBMT 05 April 2016: CAR T cells in hematologic malignancies
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69
Armored CARs
1 2
J. Park EBMT 05 April 2016: CAR T cells in hematologic malignancies
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Targeted Therapies
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Reprinted with permission. Dohner, H. Blood 2010.
Molecular heterogeneity of cytogenetically normal AML Targeted therapies
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ASP2215 (Gilteritinib) - Astellas• Potent inhibitor of FLT3, FLT3/ITD, kinase
domain mutations– Long half-life (2+ days)– CYP3A4 metabolized (as are all FLT3 TKIs)
• Planned dose 120 mg/day– Placebo available January 2016.
• Clinical Results– 127 relapsed/refractory FLT3+ AML patients treated.– ORR 58% in FLT3-mutated patients– Extremely well-tolerated– MTD 300 mg/day– DLT (at 450 mg/day): transaminitis, diarrhea
Courtesy, M. Levis 72
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Eytan M Stein1, Jessica K Altman2, Robert Collins3, et al.
AG‐221, an Oral, Selective, First‐in‐Class, Potent Inhibitor of the IDH2 Mutant Enzyme, Induces Durable Reponses in a Phase 1 Study of IDH2
Mutation Positive Advanced Hematologic Malignancies
Tumor cell
Mitochondrion
KG
IDH2
Isocitrate
Citrate
Citrate
Isocitrate
KG
IDH1
Epigenetic changesImpaired cellular
differentiation
IDH2 mutant 2-HG
Isocitrate dehydrogenase (IDH) is a critical enzyme of the citric acid cycle
IDH mutations occur in a spectrumof solid and hematologic tumors1IDH2 mutations: 9–13% of AML and 3–6% of MDS
IDH1 mutations: 6–10% of AML and 3% of MDS
IDH1/2 mutations confer a gain‐of‐function2:
increased histone and DNA methylationimpaired cellular differentiation
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Interim Analysis of a Phase 1 Trial of SGN-CD33A in Patients with CD33-positive Acute Myeloid Leukemia (AML)
• Eytan M. Stein, MD1; Anthony S. Stein, MD2, Roland B. Walter, MD, PhD, MS (Epi)3, et al.
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Looking Ahead
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Probability of Death by Day 200 Not Preceded by Relapse and of Overall Survival during Two Time Periods.
Gooley TA et al. N Engl J Med 2010;363:2091-2101.
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Leukemia relapse remains unchanged in the last two decades despite improvements in supportive care and transplant related mortality
Months
Cu
mu
lati
ve I
nci
den
ce o
f R
elap
se,
%
0
100
80
20
40
60
0 4836 6012 24
1995-1999, N=901
1985-1989, N=1124
1990-1994, N=1283
2000-2004, N=460
Cumulative incidence of relapse after HLA‐matched Sibling Donor Transplant for AML in CR1, 1985‐2004
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Optimal timing of HCT
Early HCT Delayed HCT
Appropriate timing of HCT
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Improved immune recovery predicts improved OS/Relapse RiskJ Goldberg/M. Perales/G Heller
Immune recovery parameters assessed as continuous variables over time
Factor Hazard Ratio for death
p‐value
ALC 0.88 0.006CD4 0.79 <0.001CD8 0.83 <0.001NK NS NSCD45RA 0.77 <0.001PHA 0.76 0.064
Hazard Ratio for relapse
p‐value
0.51 <0.0010.55 <0.0010.53 <0.001NS NS0.67 0.0020.49 0.010
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Strategies to enhance T cell reconstitution following allo-HSCT
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A A
A
Risk Profile
IMPROVING TRANSPLANT OUTCOMESHow do we figure it out?PATIENT
SELECTIONPolymorphisms
Maintenance
I
Better Conditioning Regimens
Better Supportive CareMaintenanceTherapyCellular Therapies
Better ProductMore cellsT cell depletion vs No TCDBulk vs Fractionation?
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A
A AA
AA
Risk ProfileRefractory patientsTargeted maintenance therapyShaffer/Stein/Tallman/Giralt
Improving HCT Outcomes
Pre HCTEarly referralLeukemia Registration ProtocolIdenitfy barriers to HCT and impact of Pyschosocial factors on HCT outcomesGiralt/Tallman/Gyurkocza/Duhamel/Applebaum/Gany
Relapse PreventionDrugsOral Aza Papa/GiraltSubq Aza: TamariTargetted ShafferCellsWT1:Koehne/OreillyCar T cells: Sadelain/Brentjens/Park/Riviere/Sauter
Prep RegimenBuMelFlu Clo Mel ThioMidi for CordsNovel radiotherapyAnti CD45 radioconjugateGyurcokzaNew antibodies anti CD33aShaffer
Supportive CareCMV CTL Oreilly/Koehne/ProckopEBV CTL Prockop/OreillyEnhancing Immune reconstitutionPerales/vandenBrinkTamari/GiraltGVHD PreventionPonce/Hanash/Perales/BarkerMicrobiotaJenq/vandenbrink/Gyrucokza/Shaffer
Graft EngineeringCD34 Selection
Pre HCT TherapyTallman/Younes/Moskowitz/Landgren
New Graft SourcesCord Blood Barker/Ponce/DahiHaplo: Shaffer
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HCT focus on value, quality and cost effectiveness
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MSK
2014 Report Card
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Quick winAML in the elderly
• 2000‐2009• 8336 pts
– Not Treated = 5009– Treated= 3327– Transplanted = 276
(increased from 50)• Prior MDS = high risk• HR for Transplant
– <= 75 = 0.63 (0.53‐0.75)– >75 = 1.2 (0.95‐1.52)
MedeirosAnn Hematol (2015) 94:1127–1138, DOI 10.1007/s00277‐015‐2351‐x
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Shanafelt JOP May 2015, http://dx.doi.org/10.1200/JOP.2014.002469
Largest Potential Impact Low grade lymphoma
Less than 5% of patients with early relapse are being considered for autograft
Cost of newly approved drugs for this indication > 100K yearly
MSKCC 4 patients a year for the last 5 years
The Game Changer…Low Grade Lymphoma
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Showing the value of BMT in Follicular Lymphoma
Follicular Lymphoma Relapsed Within 24 months
of 1ry therapy
Likely to maintain most treatment within the
MSKCC System
Aggressive Salvage Therapy
Chemo + High Dose Therapy Plus Maintenance
X yearDisease Outcomes
OS/PFS
Time to Next Treatment
X year Symptom Burden Outcomes
Longitudinal Symptom Burden
Patient Reported Outcomes
Conventional Therapy
Chemo + Maintenance
X year Cost Outcomes
Healthcare expenditures
Out of pocket expenses
X year Societal Outcomes
Time off work
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June 1, 2023
Comprehensive Comparative Effectiveness Analysis Between Autologous Hematopoietic Cell Transplantation and Modern Alternative Therapies in the
Treatment of Relapsed Follicular Lymphoma. Going Beyond Dollars and Cents.Gunjun Shah, MD, Susan Parsons, MD, Sean Devlin PhD, Peter Stetson MD, Mithat Gonon PhD, Mark
Radzyner Esq, Elaine Duck RN, Era Bani, Anas Younes MD, Craig Moskowitz, MD and Sergio Giralt, MD
Time 0 24 + mTime from Relapse
Sym
ptom
Bur
den
Uni
ts
Com
preh
ensi
ve C
ost A
naly
sis
$
Induction Consolidation Salvage Therapy
Symptom Burden Non Transplant
Symptom Burden Transplant
Healthcare Expenditures Non TransplantHealthcare Expenditures Transplant
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Medicare 2006-2011, CRG adjusted
MSK
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Summary
• Both autologous and allogeneic HCT activity is likely to continue to increase in the future.
• Optimal utilization will require continued comparative effectiveness analysis between HCT and alternative treatments.
• It is essential to make HCT easier and less toxic.• Although novel immune therapies and targeted therapies are likely to impact
the timing and utilization of HCT. They will also likely enhance efficacy and potentially increase access.
• Access will continue to be a major problem unless a concerted effort at increasing the number of HCT centers and enhancing the efficiency of existing centers. APPs will be essential in these efforts.
• Optimal utilization of HCT for patients with blood cancers will require close collaboration between community oncologist and HCT Centers
• The traditional way of doing business like the traditional Triple P transplant (push the drugs‐pour the cells and pray that it all works out) will not move the field forward nor enhance access to HCT