gain of function / dual use: eu perspective (ruxandra draghia akli)

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  • 8/19/2019 Gain of Function / Dual Use: EU Perspective (Ruxandra Draghia Akli)

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    MLVG_L@ 6:6:

    Tmn N^ Erbhnwlrc Zrlirbhhn elr Vnsnbram b`d G``lvbtgl`

    Ibg` le eu`atgl` / Dubk usn?

    N^ pnrspnatgvn

    @btgl`bk Babdnhgns le Qagn`ans,

    N`ig`nnrg`i b`d Hndgag`nG`tnr`btgl`bk Qyhplsguh l` Ibg` le Eu`atgl` rnsnbram2:-22 Hbram 6:25, Ybsmg`itl` DA

    Vuxb`drb Drbimgb-Bckg, HD, ZmD

    Mnbktm DgrnatlrDI Vnsnbram & G``lvbtgl`

    Nurlpnb` Alhhgssgl`

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    Al`tn`t

    • Mlrgzl` 6:6:? tmn N^'s Vnsnbram b`d G``lvbtgl` prlirbhhn

    • N^ eu`dnd IlE/Dubk ^sn Vnsnbram le Al`anr` (D^VA)

    • Mlrgzl` 6:6: ‑ Ntmgas

    • IlE/D^VA rnsnbram? dgbkliun wgtm stbcnmlkdnrs g` tmn N^

    • IlE/D^VA rnsnbram? rnspl`sn erlh tmn Nurlpnb` Alhhgssgl`

    • Nxbhpkns le plkgagns l` IlE/D^VA rnsnbram g` Hnhfnr Qtbtns

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    • Tmn Nurlpnb` ^`gl` prlirbhhn elr rnsnbram b`d g``lvbtgl` elr6:24-6:6: wgtm b fudint le ₫97 fgkkgl`

    • Vbtgl`bkn? V&D gs g`arnbsg`iky alhpknx, g`tnrdgsagpkg`bry, alstky,

    rnqugrg`i argtgabk hbss• Nurlpn 8 6= alu`trgns? `nnd elr g`arnbsnd alkkbflrbtgl`

    • Lvnrbramg`i bhfgtgl` le Mlrgzl` 6:6:?

    • Vnspl`d tl tmn nal`lhga argsgs tl g`vnst g` olfs b`d irlwtm

    • Bddrnss pnlpkn‗s al`anr`s bflut tmngr kgvnkgmllds, sbenty b`d n`vgrl`hn`t

    • Qtrn`itmn` tmn N^‗s iklfbk plsgtgl` g` rnsnbram, g``lvbtgl` b`d tnam`lkliy

    Mlrgzl` 6:6:

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    N^? 1/4 le ^Q tltbk elr endnrbkkyeu`dnd V&D

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    • Tmn N^ V

    Mlrgzl` 6:6: fudint frnbcdlw`

    Qlagntbk 

    Ambkkn`in 

    (QA2)? 

    Mnbktm, Dnhlirbpmga amb`in b`d 

    Ynkk fng`i 

    N^V? 9.4 fgkkgl`

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    N^ eu`dnd IlE/D^VA rnsnbram

    • Tmn purplsn le N^ V&D gs bkwbys agvgk/mnbktm usn ‑ hgkgtbry (lrhbknvlkn`t) usn gs ‑ ge bt bkk ‑ u`g`tn`tgl`bk fy-prlduat

    • @l spnagega abkk elr prlplsbks l` IlE, rbtmnr (g` mnbktm)?

    • strn`itmn` rnsnbram l` prndgatgl`, gdn`tgegabtgl`, hldnkkg`i b`dsurvngkkb`an le `nwky nhnrig`i g`enatglus dgsnbsns g` muhb`s, b`d

    • gdn`tgey ebatlrs prlhltg`i tmn nhnrin`an le pbtmlin`s wgtm muhb`pb`dnhga pltn`tgbk erlh pbtmlin`s wgtm b zll`ltga fbacirlu`d b`drnkbtnd prnvn`tgl` strbtnigns

    • G` EZ9 Mnbktm b`d M6:6: Qlagntbk Ambkkn`in 2 Mnbktm, dubk usn rnsnbram gsnxanndg`iky rbrn (EZ9? 1 lut le 0 2::: prlonats)

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    N^ eu`dnd IlE/D^VA rnsnbram

    EZ9 Mnbktm prlonats wgtm IlE alhpl`n`ts

    • NHZNVGN (Nurlpnb` Hb`binhn`t Zkbtelrh elr Nhnrig`i b`d Vn-nhnrig`i G`enatglus Dgsnbsn N`tgtgns, 6::7-6:24)

    • ZVNDNHGAQ (Zrnpbrnd`nss, Zrndgatgl` b`d Zrnvn`tgl` le Nhnrig`i_ll`ltga Ugrusns wgtm Zb`dnhga Zltn`tgbk usg`i Huktgdgsagpkg`bry

    Bpprlbamns, 6:22-6:25)

    • B@TGIL@N (B`tgagpbtg`i tmn Iklfbk L`snt le @lvnk Npgdnhgas, 6:22-6:25)

    EZ9 Mnbktm prlonats g` snaurgty rnsnbram wgtm dubk usn gtnhs

    • B`tgFltBFN (@nutrbkgzg`i b`tgfldgns bibg`st fltukg`uh tlxg`s B,F,N,6:2:-6:2>)

    • TGVBHGQ^ (Muhb`gtbrgb` Dnhg`g`i Tllkflx, 6:26-6:25)

    M6:6:? Aurrn`tky `l prlonats wgtm IlE rnsnbram

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    Mlrgzl` 6:6: - Ntmgas

    • Durg`i prlplsbk prnpbrbtgl`, bppkgab`ts brn bscnd?• ge tmngr prlplsbk mbs b` nxakusgvn agvgkgb` elaus l` rnsnbram

    • ge tmngr rnsnbram usns lr prlduans illds lr g`elrhbtgl` tmbt wgkkrnqugrn nxplrt kgan`sns g` baalrdb`an wgtm knigskbtgl` l` dubkusn gtnhs

    • Ntmgabk sarnn`g`i, elr nbam suaansseuk prlplsbk?• bt knbst 6 ntmgabk nxpnrts wgtm b vbrgnty le dgeenrn`t fbacirlu`ds n.i.

    kbw, pmgklslpmy, hndgag`n, fglkliy, rnbd tmn prlplsbk

    • Eukk ntmgabk bssnsshn`t?• rnvgnwnd fy bt knbst > ntmgabk nxpnrts elr bkk prlplsbks al`tbg`g`i

    pltn`tgbk dubk usn

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    Mlrgzl` 6:6: ‑ Ntmgas

    • Bt tmn n`d le tmn wmlkn prlanss, tmn ntmgas rnplrtstbtns?

    • aknbrb`an ‑ `l batgl`

    • al`dgtgl`bk aknbrb`an - amb`ins tl fn hbdn tl tmn dnsargptgl` le wlrc(n.i. rnqugrnhn`ts elr pnrhgts, elkklw-up, ntmgabk budgts)

    • `l aknbrb`an ‑ prlonat `lt eu`dnd

    Tmn Mlrgzl` 6:6: hldnk irb`t birnnhn`t mbs b` lptgl`bk brtgakn tl

    n`surn tmbt batgvgtgns g`vlkvg`i dubk-usn illds alhpky wgtm N^, `btgl`bkb`d g`tnr`btgl`bk kbw b`d mbvn b` nxplrt kgan`an, ge bppkgabfkn.

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    IlE/D^VA rnsnbram? dgbkliun wgtm

    stbcnmlkdnrs g` tmn N^• N^ 6= Hnhfnr Qtbtns

    • Qufsgdgbrgty prg`agpkn? `btgl`bk rnsnbram eu`dg`i 8 `btgl`bk rnspl`sgfgkgty

    • N^-wgdn rniukbtgl` le 'nxplrt al`trlk' plkgay le g`tb`igfkn tnam`lkliy

    trb`senr (N^ b`d `btgl`bk kgan`sns)

    • N^ Qagn`tgega Alhhu`gtgns

    • N^ Qlagnty elr Ugrlkliy? alhhl` plkgay elr sagn`tgega rnsnbram b`dpufkgabtgl`s

    • Elu`dbtgl` elr Ubaag`n Vnsnbram? alhprnmn`sgvn rgsc-fn`negtbssnsshn`t le IlE

    • Nurlpnb` Babdnhgns Qagn`an Bdvgslry Alu`agk (NBQBA)? wlrcg`i irlupnstbfkgsmnd g` butuh` 6:24 tl nxpklrn al`sn`sus l` cny qunstgl`s?gdn`tgey eurtmnr IlE gssuns b`d akbrgey lptgl`s elr plkgay dnvnklphn`t

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    N^ pnrspnatgvn l` stbcnmlkdnrs' vgnws

    • Tmn N^ bac`lwkndins tmn `nnd tl ghprlvn bwbrn`nss b`d fnst prbatganbhl`i hnhfnrs le tmn sagn`tgega alhhu`gty b`d tl prlhltn b` u`dnrkyg`iaukturn le rnspl`sgfgkgty igvn` tmn pltn`tgbk elr baagdn`tbk rnknbsn b`d hgsusn

    • Ynkalhns tmn Nurlpnb` Babdnhgns Qagn`an Bdvgslry Alu`agk (NBQBA)wlrcg`i irlup rnalhhn`dbtgl`s?

    • Vnsnbram bppkgabtgl`s smlukd nxpkbg` b`d oustgey tmngr IlE nxpnrghn`ts, dgsausstmn fn`negts b`d rgsc, g`dgabtn tmn fglsbenty abtnilry b`d bssnss IlE studyprlplsbks l` b absn-fy-absn fbsgs

    • Bpprlprgbtn iugdb`an l` fglsbenty b`d fglsnaurgty elr rnsnbram bppkgabtgl`s b`dnvbkubtgl`s smlukd fn igvn` b`d bkk Hnhfnr Qtbtns smlukd mbvn b aknbr `btgl`bkbdvgslry bpprlbam

    • B` g`tnr`btgl`bk elruh gs `nndnd tl sustbg` dgbkliun fntwnn` tmn kgen sagn`ans b`dplkgay-hbcg`i alhhu`gtgns, b`d wgtm ltmnr stbcnmlkdnr g`vlkvnhn`t

    • Babdnhgns le sagn`an pkby b al`tg`ug`i rlkn g` prlhltg`i b`d g`arnbsg`iu`dnrstb`dg`i le fglsbenty b`d fglsnaurgty `lrhs

    • G`elrhbtgl` l` prlandurns bkrnbdy g` pkban g` Hnhfnr Qtbtns smlukd fn alkknatnd

    b`d alkkbtnd

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    • G` rnsnbram g`stgtutgl`s, sagn`tgsts hust?• Bssnss tmn rgscs le tmngr nxpnrghn`ts

    • N`surn trbg`g`i b`d mbvn tmn nqugphn`t/ebagkgtgns sugtbfkn elr sben nxpnrghn`tbtgl`(fglsbenty knigskbtgl` g` ^C? al`trlk le mbzbrdlus sufstb`an, IHLs, spnagegnd B`ghbkZbtmlin` Lrdnr, ...)

    • Qufhgt tmngr rnsnbram prlplsbks tl tmn klabk Fglkligabk Qbenty Alhhgttnn

    • Fglkligabk Qbenty Alhhgttnn?

    • Hnhfnrs wgtm bpprlprgbtn c`lwkndin, nxpnrtgsn, b`d nxpnrgn`an tl bssnss tmnprlplsbk

    • Elr wlrc rnqugrg`i mgimky snaurn ebagkgtgns? tmn prlplsbk, wgtm tmn rnalhhn`dbtgl`s letmn Fglkligabk Qbenty Alhhgttnn, hust fn sufhgttnd tl tmn sn`glr hb`binhn`t le tmng`stgtutgl`.

    • Baanptnd prlplsbks brn sufhgttnd tl tmn Mnbktm & Qbenty Nxnautgvn fytmn nstbfkgsmhn`t‗s Fglkligabk Qbenty Leeganr, bs b "@ltgegabtgl` leG`tn`tgl` tl Al`duat G`dgvgdubk Al`tbg`nd ^sn Batgvgtgns"

    • Tmn Mnbktm & Qbenty Nxnautgvn rnvgnws tmn bppkgabtgl` b`d igvns pnrhgssgl` tl prlannd

    • Nxpnrghn`ts hust fn dl`n fy nxpnrgn`and, trbg`nd sagn`tgsts elkklwg`i sbentyprlandurns. Ge plssgfkn, vbaag`btgl` smlukd fn al`sgdnrnd3 bvbgkbfkn tmnrbpgns hbdnbaanssgfkn

    Nxbhpkns le `btgl`bk plkgagns? ^`gtnd Cg`idlh

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    • Tmn rnspl`sgfgkgty kgns egrst wgtm tmn rnsnbramnrs/g`stgtutns?• Qpnagbk ebagkgtgns, prlandurns bppkgabfkn, trbg`g`i le stbee brn supnrvgsnd fy

    tmn fglsbenty leegan

    • Bkk rnsnbram prlplsbks brn egrst sufhgttnd tl tmn fglsbenty leegan wml kllcs bttmn wgkd typn pbtmlin`s (BVFL rukns) b`d tl IHLs (IHL Dnagsgl`)

    • Qtbee mbs b fglsbenty b`d fglsnaurgty trbg`g`i updbtnd b``ubkky

    • Tmn prlplsbks brn amnacnd fy tmn g`spnatgl` snrvgans le tmn Hg`gstry?• B pnrhgt hust fn lftbg`nd erlh tmn Hg`gstry fnelrn stbrtg`i wlrc

    • G` dgeegaukt absns tmnrn brn elrhbk sagn`tgega lpg`gl`s, wmgam brn hbdn pufkgab`d rnangvn b elrhbk pnrhgt erlh tmn Hg`gstry fbsnd l` YML iugdnkg`ns

    • Bkk ntmgabk rnqugrnhn`ts brn bssnssnd fy Ntmgabk Vnvgnw Alhhgttnns• Ubaag`btgl` gs alhpukslry, wmn` neenatgvn vbaag`ns brn bvbgkbfkn

    • Tmn ilvnr`hn`t mbs b "Fglsnaurgty Leegan" mbs wmgam ab` fn al`suktndfy rnsnbramnrs/g`stgtutgl`s

    Nxbhpkns le `btgl`bk plkgagns? Tmn @ntmnrkb`ds

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    • Qupnrvgsgl` fy tmn @btgl`bk Bin`ay elr Qbenty le tmn Drui b`d Mnbktmprlduats (B@QH)• Znrsl`s wml al`duat lpnrbtgl`s g`vlkvg`i tmn usn le muhb` pbtmlin`s lr

    tlxg`s l` tmn tlxga hgarl-lrib`gshs kgst hust mlkd b` butmlrgsbtgl` gssund fyB@QH

    • Tmn al`trlk l` tmn usn le tlxga hgarl-lrib`gshs tl n`surn tmn sbenty b`d

    snaurgty rnkbtnd tl tmngr dntn`tgl` b`d usn gs hb`bind fy B@QH

    • Kghgtbtgl`/al`trlk le baanss tl elrngi` pnrsl`s g` 'sn`sgtgvn'kbflrbtlrgns?

    • Dnarnn (`º 6:22-246> @lvnhfnr 6, 6:22 l` tmn prltnatgl` le tmn sagn`tgegab`d tnam`gabk pltn`tgbk le tmn `btgl` rnpkbag`i tmn g`tnr-hg`gstnrgbkg`struatgl` @l. 4=5 le 2771

    • Knigskbtgl` l` "illd prbatgans tl iubrb`tnn fglsnaurgty, l` tmn kgst le hgarl-lrib`gshs b`d tlxg`s, l` g`elrhbtgl` rnkbtnd tl tmn butmlrgsbtgl`s,alhpntn`ans b`d qubkgegabtgl`s elr mlkdnrs le b` butmlrgsbtgl`"

    Nxbhpkns le `btgl`bk plkgagns? Erb`an

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    Knbr` hlrn?

    •  Bkk bflut ntmgas g` Mlrgzl`6:6:? vgsgt lur wnfsgtn