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GAPDH & PFK

Oleh : Neni Anggraeni (130120150011)

Tugas Mata Kuliah Gangguan Metabolisme & engenalann!a

Dosen Pengampu : Prof. Dr. M. NurhalimShahib, dr.

MAGISTER I M! "ED#"TERAN DASAR!NPAD

$%&'

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GLYCERALDEHIDE 3-PHOSPHAT

DEHIDROGENASE

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GA "#

$n%im !ang menga atalisis 'roses e enamalam gli olisis

gl()eraldeh(de *+phospha e D+gl()era e &,*+bisphospha e -&,*+ PG/

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*NG+, -A,N GA "#

+bg sensor stres sel instrasel an e strasel. mam'umenga ti/ an me anisme 'erbai an erusa an sel atau a'atmenga ti/ an me anime a'o'tosis

ila ter a i stres o si ati/. en%im ini men a i ti a a ti/+ehingga sel a'at beralih /ungsi ari /ungsi metaboli e/ungsi untu men aga eseimbangan o si asi re u si

ening atan GA "# an tera umulasi alam mito on riaa'at menga ti/ an me anisme a'o'tosis Membran

mito on ria men a i im'remeabel an mele'as an /a tor 'roa'o'toti an 4!to rom 4

$ s'resi abnormal en%im ini terlibat alam 'en!a it tertentu Terutama 'en!a it neuro egenerati/

Tristan. $t al 2011 The Diverse Functions of GAPDH : Views From Di erentSubcelluar Compartmemnts N,# ubli4 A44es

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Tristan. $t al 2011 The Diverse Functions of GAPDH : Views From Di erentSubcelluar Compartmemnts N,# ubli4 A44es

GA "# in 4!to'lasm

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Tristan. $t al 2011 The Diverse Functions of GAPDH : Views From Di erent

Subcelluar Compartmemnts N,# ubli4 A44es

GA "# inasso4iation 6its4!tos eletonan 7esi4ulartrans'ort

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GA "# in mito4hon ria Tristan. $t al 2011 The Diverse Functions of GAPDH : Views From Di erentSubcelluar Compartmemnts N,# ubli4 A44es

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GA "# sbg House!eepin""ene

8umlah gen !g tere s'resi harus i ban ing an engan umlah gen !g ban!a tere s'resi 'a a sel aringantersebut House!eepin" "ene

GA "# meru'a an salah satu house ee'ing gene !ang

'aling umum iguna an untu memban ing an umlahgen9gen !ang tere s'resi

arber. obert " $t al 2005 GAPDH as a house!eepin" "ene :anal#sis of GAPDH m$%A e&pression in a panel of '( human

tissues h!siol Genomi4s

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arber. obert " $t al 2005 GAPDH as a house!eepin" "ene :anal#sis of GAPDH m$%A e&pression in a panel of '( human

8umlah m NAGA "# untusetia'

aringan

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arber. obert " $t al 2005 GAPDH as a house!eepin" "ene :anal#sis of GAPDH m$%A e&pression in a panel of '( humantissues h siol Genomi4s

Ti a a a 'erbe aan e 'resi GA "# antara la i9la ian 'erem'uan

Ti a ter a'at 'erbe aan e s'resi GA "# 'a a'erbe aan usia

erbe aan e s'resi 'a a berbagai aringanmen4ermin an /ungsi GA "# i alam sel

$ s'resi GA "# !ang tinggi ter a'at 'a a aringan!g membutuh an energi !g tinggi Otot. antung(7entri el iri) an ota

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FOSFOFRUKTOKINASE

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K

en%im inase engan berat mole ul ; 3

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$n%im ini a'at ihambat atau irangsang olehbebera'a metabolit. !aitu sen!a6a !ang terlibat

alam 'roses gli olisis

AT berlebih an asam sitrat a'at menghambater a /os/o/u to inase Namun. isaat !ang samaa'at 'ula merangsang en%im ini engan a an!a

e/e tor 'ositi/ ari AM . A" . an /u tosa9

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ebera'a 'enelitian menun u an bah6a a ti@tas K mening at'a a 4an4er 4ell line. begitu uga 'a a sel 'rimer tumor sgbres'on 'roli/erasi sel

A ti7itas K men a i target 'engobatan 'a a an er Tu uann!auntu membatasi a ti7itas gli olisis 'a a sel tersebut

Al #a6a6i. Na a 201> Phosphofructo!inase: A me)iator of "l#col#tic *u& in cancer

pro"ression $l+$?,$ riti4al e7ie6 in On4olog! #ematolog!