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An Overview of Bariatric Surgery
Kristin Dermody
Angela Illing
May 23, 2005
THE OBESITY THE OBESITY EPIDEMICEPIDEMIC
A Quick Background of ObesityA Quick Background of Obesity Derived from the Latin word obesus – “to
devour” Definition: having a very high amount of
body fat in relation to lean body mass Classifications using Body Mass Index
(BMI)
BMI CategoriesBMI Categories A BMI of: Classifies one as:
<18.5 Underweight 18.5-24.9 Normal weight 25-29.9 Overweight 30-34.9 Obesity Class I 35-39.9 Obesity Class II 40-49.9 Obesity Class III 50 and above Super Obesity
Obesity is a BIG problem… 1.7 billion worldwide
are overweight or obese
The US has a higher percentage of overweight and obese people than any country in the world
And the numbers are growing…
US Incidence of Obesity Approximately 2/3 of the United States
population is overweight. Of those, almost 50% are obese. In total, approximately 5% of the US
population is morbidly obese Alarmingly, the BMI subgroups growing
the most quickly are 35 or higher and 40 or higher.
Massachusetts: Not-so-’Phat’ Facts 55% of Mass adults overweight or obese* Of these obese adults**
18% non-Hispanic white 30% non-Hispanic black 22% Hispanic
24% of Mass high school students overweight or at risk of becoming overweight Obesity rate among Mass adults by 81% from 1990 to 2000*
*CDC BRFSS, 2002; **CDC YRBSS, 2003
History of Obesity
Source: Behavioral Risk Factor Surveillance System, CDC.
Obesity Trends* Among U.S. AdultsBRFSS, 1985
No Data <10% 10%–14%
(* BMI ? 30, or ~ 30 lbs overweight for 5’ 4” person)
1985
Source: Behavioral Risk Factor Surveillance System, CDC.
19961991
2003
Obesity Trends* Among U.S. AdultsBRFSS, 1991, 1996, 2003
(* BMI 30, or about 30 lbs overweight for 5’4” person)
No Data <10% 10% –14% 15%–19% 20%–24% ? 25%
Potential Consequences of Obesity Obesity is associated with a rise in many comorbid
conditions, including: Type 2 Diabetes Hyperlipidemia Hypertension Obstructive Sleep Apnea Heart Disease Stroke Asthma Back and lower extremity weight- bearing degenerative problems Cancer Depression AND MORE!
CVD & Obesity Fact: Obesity contributes to these co-morbid
conditions, however… Recent JAMA article by Gregg et al* suggests
CVD risk factors across all BMI groups over past 40 years Suggest: Overweight not quite as bad as it once was,
considering other factors: Risk r/t awareness, aggressive identification,
pharmacological tx of high chol, HTN. Note: Obese persons still have risk factor levels
vs..lean persons.
Gregg EW, et al. Secular Trends in Cardiovascular Disease Risk Factors According to Body Mass Index in US Adults. JAMA, 2005:293:1863-1874
Impact of Obesity These comorbid conditions are together
responsible for more than 2.5 million deaths per year worldwide*.
This is in addition to billions of dollars in healthcare costs and lost productivity.
*World Health Organization, World Health Report 2002
Obesity and Life Expectancy
Recent NEJM article* – If current rates of obesity are left unchecked, the current generation of American children will be the first in two centuries to have a shorter life expectancy than their parents.
The life-shortening impact of obesity (currently estimated at 1/3 to ¾ year) could rise to 2 to 5 years, or more, as obese children spend more years at risk for comorbid conditions.
Olshansky SJ, et al. A Potential Decline in Life Expectancy in the United States in the 21 st Century. NEJM, 352(11):1138-1145, 2005
Obesity and Life Expectancy
The morbidly obese are perhaps the worst off… Compared to a normal-weight person, a 25-
year-old morbidly obese man has a 22% reduction in expected remaining lifespan.
This is an approximate loss of 12 YEARS! This number will also likely grow if the ever-
expanding numbers of currently obese children continue as obese adults…
TREATING TREATING OBESITYOBESITY
Weight Loss Strategies Diet therapy Increased Physical Activity Pharmacotherapy (e.g., Orlistat, Meridia) Behavioral Therapy Hypnosis Any combination of the above
Bariatric Surgery
An effective treatment for combating obesity
Bariatric Surgery 1991: NIH establishes
guidelines for the surgical therapy of morbid obesity Recommends BMI criteria
BMI > 40 BMI > 35 + significant
comorbidities
This therapy now referred to as Bariatric Surgery
Types of Bariatric Surgery Purely Restrictive
Gastric Balloons (not approved for use in USA) Vertical-banded gastroplasty Gastric adjustable banding (BWH)
Restrictive > Malabsorptive Short-limb/Roux-en-Y gastric bypass (BWH) Long-limb/distal Roux-en-Y gastric bypass
Malabsorptive > Restrictive Biliopancreatic diversion (BPD) BPD with duodenal switch Very long limb Roux-en-Y gastric bypass
Purely Malabsorptive Jejunoilieal bypass Jejunocolonic bypass
A Brief History of Bariatric Surgery First developed:
Pts with short bowel syndrome weight loss First weight loss surgeries (ca. 1950s)
Intestinal bypass Low-risk surgically BUT many patients
developed serious and often fatal complications
Biliopancreatic diversion Effective BUT with high risk and many
complications
Evolution of the Roux-en-Y
Gastric partitioning (Roux-en-Y GBP) Based on observations of weight loss in pts
receiving subtotal gastric resections for other conditions
1967 – First performed Continues to be studied and refined
Roux-en-Y Open*
2 hour procedure 3 days in-house 4 weeks – Return to work 60-70% EBW loss @ 2 yrs 0.5-1.0% Risk of Death Dumping Syndrome
Laparoscopic* 2-4 hour procedure 3 days in-house 2-3 weeks – Return to work 60-70% EBW loss @ 2yrs 0.5-1.0% Risk of Death Dumping Syndrome
* Data based on averages.
Evolution of Gastric Banding 1970s
Alternative to Roux-en-Y in Europe & Scandinavia
1980s Adjustable silicone band developed
1990s Laproscopic techniques for placement
developed
Gastric Banding Adjustable Lap Band
1 hr procedure 1 day in-house 1 wk – Return to
work 40-45% EBW loss
@ 2 yrs <0.1% Risk of Death Self-sabotage easier
Who Gets Bariatric Surgery? Gender
19% Males 72.6% Females (8% gender not reported)
Age Mean age 39 years Range 16-64 years
BMI Mean BMI 46.9 Range 32.3-68.8
Buchwald H, et al. Bariatric Surgery: A Systematic Review and Meta-analysis. JAMA, 14:1724-37, 2004
Medical Nutrition Therapy and
The Post-op Bariatric Patient
Post-Surgical Nutrition Balanced/healthy diet Liquids to pureed to soft to solid* High nutrient density, quality Modified in lactose, fat, sugar Adequate fluid Portion Control Meal Periods/Eating time MVI/MIN
Ca (>1200mg/d) + D (10-20mg) Folate (800-1000mcg) +B12 Iron (45-100mg elemental – pre-
menstrual) Vitamin C (75-100mg) Thiamin
Self-monitoring Eating triggers/behaviors Exercise
* Time line may vary among institutions
Post-Op Roux-En-Y Diet Stage One (1 day)
Water and clear liquids Non-caloric, non-
carbonated, non-caffeinated liquids
Fluid goal: 28-32oz/d Stage Two (14 days)
High protein, low sugar beverages
Fluid goal: 56oz Protein goal: 60-70g/d Chewable MVI + Ca
Post-Op Roux-En-Y Diet Stage Three (4 weeks)
5 – 2oz servings diced protein
Fluid goal: 56oz Protein goal: 60-70g Chewable MVI + Ca
Stage Four (4 months) 3 meals, 2 snacks 850kcal/d Fluid goal: 56oz Protein goal: 60-70g Chewable MVI + Ca
Stage Five (ongoing)Regular Meals1200-1500kcalFluid & Protein goals: same as above
Post-op Lap Band Diet Stage One (1 day)
Water & Clear Liquids Non-carbonated, non-caffeinated, non-caloric liquids Fluid goal: 28-32oz/d
Stage Two (14 days) 5-8oz servings of High Protein, low sugar Beverage Fluid goal: 56oz Protein goal: 50-60g Chewable MVI + Ca
Post-op Lap Band Diet Stage Three (14 days)
Pureed Foods, Semi solids 2 small meals, 3 snacks Fluid goal: 56oz Protein goal: 50-60g Chewable MVI + Ca
Stage Four (ongoing) Regular meals: 3 meals,2 snacks (1000-1200) Fluid goal: 56oz Protein goal: 50-60g Chewable MVI + Ca
Post-Surgical Nutrition & Exercise
RD seen frequently 1m 3m 6m 1yr
Exercise No heavy lifting or exercise 6-8wks post-op Walking daily OK, encouraged After cleared, strength training important to
help skin stretch back Helps with weight loss in the long run
When Surgery and Follow-Up Go Well…
Efficacy of Bariatric Surgery for Weight Loss
Mean percentage excess weight loss: 61.2% - All Patients 47.5% - Gastric Banding 61.6% - Gastric Bypass 68.2% - Gastroplasty 70.1% - BPD or duodenal switch
*Buchwald H, et al. Bariatric Surgery: A Systematic Review and Meta-analysis. JAMA, 14:1724-37, 2004
Human body regulates nutrient intake over time by secreting hormones
Over 40 hormones play a role in regulation of feeding.
Roux-en-Y: Metabolic Sequelae
Roux-en-Y: Metabolic Sequelae Two types:
Satiety hormones Short-term Help regulate meal size; daily intake Secretion decreases meal size; reduces time to stop Includes (among others) cholecystokinin, amylin, glucagon-
like-peptide 1 (GLP-1), enterostatin, and bombesin Adiposity hormones
Long-term Related to energy stores Secretion delays onset of beginning of meal Includes insulin, leptin
Roux-en-Y: Metabolic Sequelae Also of note is ghrelin, the
endogenous ligand for the growth hormone secretagogue receptor
Mostly secreted in the fundus of the stomach (part bypassed in RYGB)
Contrary to satiety hormones, ghrelin is orexigenic – i.e., increases appetite (fasting increases levels)
Roux-en-Y: Metabolic Sequelae Plasma ghrelin normally increases after
non-surgical weight loss This supports long-term weight homeostasis Proportional to lean body mass
Initial report showed circulating plasma ghrelin greatly decreased in pts s/p RYGB
Past theory: exclusion of the fundus of the stomach responsible for lower ghrelin levels (and therefore greater weight loss)
Studies since then have shown no change or increase in ghrelin after bypass
Additionally, found that post-pyloric nutrient stimulation vs.. stomach distention responsible for changes in ghrelin levels Does not support idea that bypassing stomach
fundus responsible for changes, if any, in ghrelin levels
Overall, still not well understood
Roux-en-Y: Metabolic Sequelae
Strader AD, et al. Gastrointestinal Hormones and Food Intake. Gastroenterology, 128:175-91, 2005
Roux-en-Y: Metabolic Sequelae Further investigation is needed, but thought that
one reason certain types (i.e., RYGB) of bariatric surgery are successful at reducing food intake and causing weight loss may be related to enhanced secretion of satiety signals (ghrelin or others).
Effect on Comorbid Conditions Diabetes
76.8% - Completely resolved 86.0% - Resolved or improved
Hyperlipidemia 70% - Improved
HTN 61.7% - Resolved 85.7% - Resolved or improved
Obstructive Sleep Apnea 83.6% - Resolved 85.7% - Resolved or improved
Buchwald H, et al. Bariatric Surgery: A Systematic Review and Meta-analysis. JAMA, 14:1724-37, 2004
Metabolic Changes and Diabetes Many metabolic changes contribute to improvement
and/or resolution of DM s/p bariatric surgery: Recovery of acute insulin response Decreases of inflammatory indicators (C-reactive
protein and interleukin 6) Improvement in insulin sensitivity correlated
w/increases in plasma adiponectin Changes in the enteroglucagon response to glucose Reduction in ghrelin levels (s/p RYGB, but not
banding) Improvement in beta cell function (s/p banding, but
not RYGP)
Effect on Quality of Life Studies show overall QOL greatly improved
Relief from comorbidities Improved appearance Perception of improved:
Well-being Social function Body self-image Self confidence Ability to interact with others
Increased time spent in recreational and physical activities Enhanced productivity Increased economic opportunities
Often new employment More lucrative employment
PROBLEMS AND PROBLEMS AND COMPLICATIONSCOMPLICATIONS
of Bariatric Surgery
Possible Complications of Bariatric Surgery
General Complications Pulmonary embolism Incisional hernia Gallstone formation Major wound infection and seroma Abdominal fluid collection Subphrenic abscess Peritonitis
Procedure-Specific Complications (RYGB)
Anastomotic or staple-line leak Acute gastric distention Staple-line disruption Stomal stenosis Stomal ulceration Small-bowel obstruction Occlusion of Roux limb
Intermediate Complications Wound Infection Intra-abdominal bleed Gastric remnant necrosis Ischemic Roux-limb Internal hernia
Long-Term GI Complications Nausea Constipation Abdominal pain Marginal ulcers Incisional hernias Vomiting Diarrhea Gallstones Gastritis Intestinal Obstructions
Incidence of Complications Operative mortality (< 30 days):
0.1% for Purely Restrictive Procedures 0.5% for Gastric Bypass 1.1% for BPD or Duodenal Switch
Long-Term Nutrition Complications Malnutrition Vitamin and mineral deficiencies Weight loss failure Dehydration Anemia Dumping Syndrome Hair loss Dry skin
Risk of Vitamin and Mineral Deficiencies Post-op
Calcium and Vitamin D Reduced absorption d/t bypassed duodenum, proximal jejunum
(R-en-Y) Life-long supplements mandatory
Iron Absorption decreased d/t decreased contact of food with gastric
acid; reduced conversion of iron from ferrous to ferric form (MVI) Vitamin B12
Absorption decreased d/t decreased contact with intrinsic factor 60% of patients require long term supplementation of B12
Thiamine Connection to Wernicke’s syndrome Cases not well documented
Post-Surgical Eating Avoidance Disorder (PSEAD)
De novo synthesis of eating disorders post-GBP No history pre-operatively
Do not fit criteria for AN, BN, or BED Classify now as EDNOS
Characteristics consistent enough to suggest new eating disorder
Post-Surgical Eating Avoidance Disorder (PSEAD)
Proposed Criteria: Previous h/o morbid obesity followed by
bariatric surgery over the last 2 years Higher speed of weight loss than the average Use of purgative strategies or excessive
reduction of food intake, related or not related to binge eating episodes
Post-Surgical Eating Avoidance Disorder (PSEAD)
Proposed Criteria: Reaction of extreme anxiety +/or negative
attitude when nutritional correction introduced Intense fear of going back to pre-op wt Does not accept attempts to interrupt the wt loss Denies doing something exaggerated that
account for loss Perceives a positive return with wt loss in spite
of evidence to the contrary
Post-Surgical Eating Avoidance Disorder (PSEAD)
Proposed Criteria: Body image dissatisfaction or distortion Follow-up nutritional tests (such as laboratory tests)
alterations that are significant and/or not in line with the surgical technique, maintained for more than 2 months after initial interventions
Exclude AN and BN, according to DSM IV Exclude Simple Phobias (I.e., Food or Choking
Phobia) according to DSM IV Exclude organic causes as the most probable factor
for excessive weight loss
Segal et al. Post-Surgical Refusal to Eat: Anorexia Nervosa, Bulimia Nervosa or a New Eating Disorder? A Case Series. Obes Surg, 14:353-359, 2004
Post-Surgical Eating Avoidance Disorder (PSEAD)
A proposed ED classification Not yet part of the DSM IV
ED: Contraindication for GBP? Pt with h/o of AN or BN likely not a good
surgical candidate Pt at high risk for malnutrition after surgery
Some with h/o ED receive surgery Important to screen carefully before AND
monitor closely post-op to prevent relapse of disorder, malnutrition.
Long Term Impact Long Term Impact & &
Future DirectionsFuture Directions
Long-Term Changes: Weight Regain One study of 342 gastric bypass pts showed
excellent long-term weight maintenance: % weight loss at:
1 year (89%) 2 years (87%) 5 years (70%) 10 years (75%)
However, potential for pouch stretch, self-sabotage, etc. leading to weight regain over time.
Surgery relatively new, will have to wait and reanalyze data in a few years.
“Long-term changes in energy expenditure and body composition
after massive weight loss induced by gastric bypass surgery”
Das SK, et al. Am J Clin Nutr. 2003;78:22-30.
Study: EE & Body Composition Objective:
To determine changes in energy expenditure and body composition with weight loss after gastric bypass surgery; to identify pre-surgery indicators of weight loss.
Study: EE & Body Composition Design & Methods:
Included 30 obese men and women Average age 39.0 + 9.6 y Average BMI (kg/m2) 50.1 + 9.3
Tested longitudinally under weight-stable conditions before surgery and after weight loss and stabilization (14 + 2 mo)
Measured total energy expenditure (TEE), resting energy expenditure (REE), body composition, and fasting leptin
Study: EE & Body Composition Results:
Weight loss 53.2 + 22.2 kg body weight Significant reduction in REE (-2.4 + 1.0 MJ/d; P <
0.001) and TEE (-3.6 + 2.5 MJ/d; P < 0.001). Changes in REE predicted by changes in fat-free
mass and fat mass Average physical activity level (TEE/REE) was 1.61
at both baseline and follow-up (P = 0.98) Weight loss predicted by baseline fat mass and BMI
but not by any energy expenditure variable or leptin. Measured REE at follow-up was not significantly
different from predicted REE.
Study: EE & Body Composition Conclusions:
TEE and REE decreased by 25% on average after massive weight loss and weight stabilization after gastric bypass
Decreases in REE largely or completely predicted by decreases in body FFM and fat mass
Fasting leptin at baseline found not to be a predictor of energy efficiency/changes, as some previous studies had shown
Study: EE & Body Composition Conclusions:
Suggested further studies to examine other explanations for variability in weight loss between patients after gastric bypass surgery ? Psychological, behavioral factors
Suggested permanent reduction in energy intake critical for long-term weight management
Other Future Weight Loss Strategies Gastric stimulation – idea of placing a
pacemaker-like device in stomach to control contractions; release of hunger/satiety hormones
Hormone therapy - “exendin-4” Hormone produced in Gila monster salivary gland Similar to GLP-1 in humans
Reduces gastric emptying Lowers fasting plasma glucose Reduces food intake
May prove effective therapy for DM, obesity
OTHER CONCERNS OTHER CONCERNS
Nutrition Support in the Critically Ill GBP Patient
Enteral feeding possible, if warranted: Tube surgically placed in excluded stomach
(RYGBP) Nasoenteric tube placed endoscopically
through pouch If neither option possible (e.g. if pt has
anastomotic leak) TPN.
Bariatric Surgery in Special Populations
Adolescents
Elderly (over 60)
Adolescents Few medical centers currently performing
bariatric surgery on this population Only extreme cases
Highly controversial given incomplete growth period
Specialized medical team only
Elderly Advanced age common contraindication to
surgery Research suggests age may not be as
indicative of outcome as once believed Successful GBP cases in 60+*
St.Peter, Shawn. Impact of Advanced Age on Weight Loss and Health Benefits After Laparoscopic Gastric Bypass. Arch Surg; 140:165-168;2005
Spouses of GBP Patients Study by Madan AK, et al (2005) showed
gastric bypass patient’s spouses who are obese are more likely to have weight gain while the patients lose weight after surgery Suggest pre-operative counseling for spouses
or even consider them for surgery as well
Summary Bariatric surgery is a seemingly effective therapy for
morbid obesity that is gaining in popularity and prevalence
Bariatric surgery provides significant Loss of excess body weight Relief from comorbidities:
DM, HTN, hyperlipidemia Improvement in QOL for patients
However, these surgeries put pts at risk for Post-op complications & mortality Nutritional deficiencies & GI complications Psychosocial complications
References Kim JJ, et al. Surgical Treatment for Extreme Obesity: Evolution of
a Rapidly Growing Field. Nutr Clin Prac 18:109-23, 2003 Buchwald H, et al. Bariatric Surgery: A Systematic Review and
Meta-analysis. JAMA, 14:1724-37, 2004 Olshansky SJ, et al. A Potential Decline in Life Expectancy in the
United States in the 21st Century. NEJM, 352(11):1138-1145, 2005 Merkle EM, et al. Roux-en-Y Gastric Bypass for Clinically Severe
Obesity: Normal Appearance and Spectrum of Complications at Imaging. Radiology, 234(3):674-83, 2005
Segal et al. Post-Surgical Refusal to Eat: Anorexia Nervosa, Bulimia Nervosa or a New Eating Disorder? A Case Series. Obes Surg, 14:353-359, 2004
Madan AK, et al. Weight changes in spouses of gastric bypass patients. Obes Surg, 15(2):191-4, 2005
References Strader AD, et al. Gastrointestinal Hormones and Food Intake.
Gastroenterology, 128:175-91, 2005 Das SK, et al. Long-term changes in energy expenditure and body
composition after massive weight loss induced by gastric bypass surgery. Am J Clin Nutr. 2003;78:22-30.