gates london poster oct 2016 - amazon s3london...developingbrainfunctionforagecurvesin*...

Developing brain function for age curves in Gambian and UK infants S. Lloyd)Fox 1,2 , A. Blasi 2 , L. Mason 2 , D. Halliday 1 , K. Begus 2 , P. Vellekoop 4 , M. Papademetriou 1, M. K. Darboe 3 , A. M. Prentice 3,4 , M. de Haan 6 , L. Kischkel 6 , T. Austin 7 , M. Rozhko 8 , S. E. Moore 3,8 , C. E. Elwell 1 Project Description • The ultimate aim of the Phase II project is to establish standard curves of brain function9for9age and to use these to identify early biomarkers of disrupted neurocognitive development. • Our ambition is to redefine what can be investigated in the developing brain of infants at risk in low9 and middle9 income countries so that we can deliver and assess the efficacy of targeted interventional strategies GCE Phase I Summary 99 infants were studied between birth and 24 months of age: fNIRS, Mullen Scales of Early Learning. • Two sites: MRC field station, Keneba village, Gambia (N = 200) Rosie Hospital, Cambridge, UK (N = 50) • fNIRS paradigms: social (SOC), attention (ATT), working memory (WM) and functional connectivity (FC); EEG paradigm: auditory oddball (from the Intergrowth study); Eye9tracking paradigm (from the Life study); Cognitive Development Assessments: Neonatal Behavioural Assessment Scale (NBAS), Mullen Scales of Early Learning (MSEL), Parent9Child Interaction Measures, Child Development Inventory (CDI); Demographics, Socioeconomic status (SES), Maternal and Infant health and diet, HOME Inventory; Anthropometric/Biological measures: Mother (M), Infant (I) Lloyd&Fox, S., et al. (2014). Functional near infrared spectroscopy (fNIRS) to assess cognitive function in infants in rural Africa. Nature Scientific Report, 4:4740, DOI: 10.1038/srep04740 Lloyd&Fox, S., et al. (in press). Cortical specialisation to social stimuli from the first days to the second year of life: A rural Gambian cohort. Developmental Cognitive Neuroscience. www.globalfnirs.org Brain Imaging for Global Health More Information Email: [email protected] Twitter: @globalfnirs GCE Phase II Project Outline: Longitudinal study from birth, 1, 5, 8, 12, 18 & 24 months of age 1 Department of Medical Physics and Bioengineering, University College London, UK> 2 Centre for Brain and Cognitive Development, Birkbeck, University of London, UK 3 MRC International Nutrition Group, Keneba Field Station, The Gambia> 4 MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, UK> 5 Institute of Child Health, UCL> 6 Evelyne Perinatal Imaging Centre, Cambridge University Hospitals> 7 MRC Human Nutrition Unit, Cambridge. 0&2 months 4&8 months 12&16 months 18&24 months Functional Near Infrared Spectroscopy • fNIRS, an optical imaging technique, uses near infrared light to measure changes in brain blood flow and oxygen consumption (oxy9 (HbO 2 ) and deoxy9 (HHb) haemoglobin) associated with neuronal activation. • fNIRS offers superior spatial resolution to EEG, and unlike fMRI, is well suited to field studies. It is completely safe, low cost and requires minimal set up and training. 1) shine and detect light 2) and measure changes in HbO 2 (red) and HHb (blue) in response to neuronal activation Faltering head growth is apparent by 12 months of age in rural Gambian infants. Associated neurocognitive ramifications are poorly understood (Moore et al., unpublished). MSEL Growth PCI fNIRS and Eye9tracking Questionnaire development New team of field workers and researchers Home visits EEG Piloting in UK

Upload: others

Post on 12-Sep-2020

0 views

Category:

Documents

0 download

Report

Download

Embed Size (px):

TRANSCRIPT

Developing*brain*function*for*age*curves*in*Gambian*and*UK*infants

S.#Lloyd)Fox1,2,#A.#Blasi2,#L.#Mason2,#D.#Halliday1,#K.#Begus2,#P.#Vellekoop4,#M.#Papademetriou1, M.#K.#Darboe3,#A.#M.#Prentice3,4,#M.#de#Haan6,#L.#Kischkel6,#T.#Austin7,#M.#Rozhko8,#S.#E.#Moore3,8,#C.#E.#Elwell1

Project(Description• The(ultimate(aim(of(the(Phase(II(project(is(to(establish(standard(curves(of(

brain(function9for9age(and(to(use(these(to(identify(early(biomarkers(of(

disrupted(neurocognitive(development.

• Our(ambition(is(to(redefine(what(can(be(investigated(in(the(developing(

brain(of(infants(at(risk(in(low9 and(middle9 income(countries(so(that(we(

can(deliver(and(assess(the(efficacy(of(targeted(interventional(strategies

GCE(Phase(I(Summary99(infants(were(studied(between(

birth(and(24(months(of(age:(fNIRS,(

Mullen(Scales(of(Early(Learning.((

• Two(sites:(MRC(field(station,(Keneba village,(Gambia((N(=(200)

Rosie(Hospital,(Cambridge,(UK((N(=(50)

• fNIRS paradigms:(social((SOC),(attention((ATT),(working(memory((WM)(and(functional(connectivity((FC);(EEG(paradigm:(auditory(oddball((from(the(Intergrowth(

study);(Eye9tracking(paradigm((from(the(Life(study);(Cognitive(Development(Assessments:(Neonatal(Behavioural Assessment(Scale((NBAS),(Mullen(Scales(of(Early(

Learning((MSEL),(Parent9Child(Interaction(Measures,(Child(Development(Inventory((CDI);(Demographics,(Socioeconomic(status((SES), Maternal(and(Infant(health(

and(diet,(HOME(Inventory;(Anthropometric/Biological(measures:(Mother((M),(Infant((I) Lloyd&Fox,*S.,*et*al.*(2014).*Functional*near*infrared*spectroscopy*(fNIRS)*to*assess*cognitive*function*in*infants*in*rural*Africa.*Nature'Scientific'Report,'4:4740,'DOI:*10.1038/srep04740

Lloyd&Fox,*S.,*et*al.*(in*press).*Cortical*specialisation*to*social*stimuli*from*the*first*days*to*the*second*year*of*life:*A*rural*Gambian*cohort.*Developmental'Cognitive'Neuroscience.

www.globalfnirs.org

Brain Imaging for Global Health

More(InformationEmail:*[email protected]:*@globalfnirs

GCE(Phase(II(Project(Outline:(Longitudinal(study(from(birth,(1,(5,(8,(12,(18(&(24(months(of(age

1Department*of*Medical*Physics*and*Bioengineering,*University*College*London,*UK>*2Centre*for*Brain*and*Cognitive*Development,*Birkbeck,*University*of*London,*UK 3MRC*International*Nutrition*Group,*Keneba Field*Station,*The*Gambia>*4MRC*International*Nutrition*

Group,*London*School*of*Hygiene*and*Tropical*Medicine,*UK>*5Institute*of*Child*Health,*UCL>*6Evelyne*Perinatal*Imaging*Centre,*Cambridge*University*Hospitals>*7MRC*Human*Nutrition*Unit,*Cambridge.

0&2*months 4&8*months 12&16*months 18&24*months

Functional(Near(Infrared(Spectroscopy

• fNIRS, an(optical(imaging(technique,((uses(near(infrared(

light(to(measure(changes(in(brain(blood(flow(and(oxygen(

consumption((oxy9 (HbO2)(and(deoxy9 (HHb)(haemoglobin)(

associated(with(neuronal(activation.(

• fNIRS offers(superior(spatial(resolution(to(EEG,(and(unlike(

fMRI,(is(well(suited(to(field(studies.(It(is(completely(safe,(

low(cost(and(requires(minimal(set(up(and(training.

1) shine(and(detect(light

2) and(measure(changes(in(HbO2

(red)(and(HHb (blue)(in(response(