gene mutation

Gene Mutation

AGB 121

Dept. Of AGB

Veterinary College, Bangalore

Molecular GeneticsChromosome

DNA

Nucleotides

Nucleus

Cell

Dr R Jayashree, Asst. Prof(AGB) Veterinary College, Bangalore

DNA(deoxyribonucleic acid)

mR

NA

Protein


Properties of DNA


Amino acid chain


Properties of Genetic code


Gene Mutation

• Any heritable change in the genetic material

• Sudden change in the gene or genotype involving the alteration in the genetic material


Classification of gene mutation

Based on Type of cells1.Somatic mutation 2.Gametic mutation

Molecular changes1. Point mutation 2.Structural Mutation

i. Same sense i. Transitionii. Non sense ii.Transversioniii. Mis senseiv. Frame shift Dr R Jayashree, Asst. Prof(AGB)

Veterinary College, Bangalore

Molecular mutation


Point mutation


i. Same senseii. Non senseiii. Mis senseiv. Frame shift

Frame shift mutation


Structural Mutation

• Transition mutation

• Transversion mutation


Induced Mutation

• Radiation :

a. Ionizing radiation

i) Single strand Breakage - Repairable

ii) Double strand breakage

iii) Alteration in nucleotide bases

b. Non ionizing radiation :U-V rays

Thymine dimer causing distortion of double helix


Induced Mutations


DNA damage


Chemical mutagens

• Base analog mutants: Produces mutation during DNA replication – 5 bromouracil is a base analog to Thymine A=T results in A=Bu

• Chemical reactants: Produces mutagenesis in both replicating and non replicating DNA

Nitrous acid convert the amino group of Adenine , Cytosine and Guanine to Keto group

Hence Hydrogen bonding properties of the bases changes AT GC


Thank you


gene mutation

Documents

profagb veterinary college

bangaloredr r jayashree

gcdr r jayashree

genetic materialdr r

agbveterinary college

frame shiftdr r jayashree

frame shift dr r jayashree

somatic mutation