general assembly – trimage munich – 12 december 2014 “ a dedicated trimodality (pet/mr/eeg)...
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GENERAL ASSEMBLY – TRIMAGEMUNICH – 12 December 2014
“A dedicated trimodality (PET/MR/EEG) imaging tool for schizophrenia”
GA no. 602621- Last version 13 June 2014
“The first year of the TRIMAGE project”Alberto Del Guerra (University of Pisa, Coordinator)
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A dedicated trimodality (PET/MR/EEG) imaging tool for schizophrenia
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HAPPY BIRTHDAYTRIMAGE
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Contents• History• Beneficiaries• Aims of the projects• Time schedule
- Reporting documents- Deliverables
• Budget• Publications• Website
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• Acceptance of the project by EU 23.IV.2013• Closure negotation with EU 19.VII.2013• CA (4.VI.2013)• GA (signed by the commission 3.IX.2013)• Addendum to CA (30.X.2013)
• Kick off Meeting in Pisa (10&11.XII.2013)• Technical Design Report –TDR (26.III.2014)• GA amendments (13.VI.2014)• End of first year Meeting in Munich 12-XII-2014
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History
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• The Eleven Beneficiaries
• 1. UNIVERSITA’ DI PISA (the Coordinator) (UNIPI)
• 2. TECHNOLOGICAL EDUCATIONAL INSTITUTION OF ATHENS(TEIA)
• 3. FORSCHUNGSZENTRUM JUELICH GMBH (JÜLICH)
• 4. UNIVERSITAET KLINIKUM AACHEN (AACHEN)
• 5. KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN (TUM)
• 6. UNIVERSITAET ZUERICH ( UZH)
• 7. ISTITUTO NAZIONALE DI FISICA NUCLEARE ( INFN)
• 8. Advansid SRL (Advansid)
• 9. WEEROC SAS ( Weeroc)
• 10. raytest Isotopenmessgeraete GmbH (raytest)
• 11. RS2D (RS2D)
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The 11 Beneficiaries
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• “A dedicated trimodality (PET/MR/EEG) imaging tool for schizophrenia”
• TRIMAGE aims to create a trimodal, cost-effective imaging tool consisting of PET/MR/EEG using cutting edge technology with performance beyond the state of the art.
• The tool is intended for broad distribution and will enable effective early diagnosis of schizophrenia and possibly other mental health disorders.
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The aim of TRIMAGE
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• - S&T objective 1: Find new biomarkers and define a suitable multimodal paradigm with already available PET, MR, EEG and PET/MR systems that provides clinical evidence on the feasibility of advanced schizophrenia diagnosis.
• - S&T objective 2: Construct and test an optimized cost-effective trimodality imaging instrument (brain PET/MR/EEG) for diagnosis, monitoring and follow-up of schizophrenia disorders.
• - S&T objective 3: Validate the trimodal imaging device built by this Consortium with regard to the results and the clinical data obtained from objective 1.
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The 3 main aims of TRIMAGE
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• Very tight time schedule (4 years extension?)• Deliverables to be delivered on deadline,
as from GA, see below• Milestones are decision steps for the project;
only to be discussed in the “reporting period” documents
• “Reporting period” documents (3 + FINAL)
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TIME Schedule
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Reporting periods (from the GA) • At month 18 (31.V.2015)• At month 36 (30.XI.2016)• At month 48 (30.XI.2017)
• Documents to be submitted within 2 months from the expiration of the reporting period,i.e.: 31.VII.2015; 31.I.2017; 31.I.2018
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Reporting documents
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#1 Deliverable number
D4-1
Deliverable Title Magnet and MR coil specifications
WP related number 4
Lead beneficiary number
11 –RS2D
Estimated indicative person-months
44
Nature Dissemination level
R/CONFIDENTIAL
Delivery date (Month)
12 (delivered to EU by the coordinator 29 november 2014)
OK
DELIVERABLE TABLE in order of time
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#2 Deliverable number D3-1Deliverable Title Characterization of the detector module and
onthe compatibility with magnetic fields
WP related number 3Lead beneficiary number 1-UNIPIEstimated indicative person-months
144
Nature Dissemination level R/CONFIDENTIALDelivery date(Month) 18
#3 Deliverable number D6-1Deliverable Title Submission of the application to conduct a
clinical trial to the"Bundesinstitut fuer Arzneimittel and Medizinprodukte",including ethics approvals,registration and protocol
WP related number 6Lead beneficiary number 3- JULICHEstimated indicative person-months
4
Nature Dissemination level R/PP (restricted to other program participants)Delivery date (Month) 26
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#4 Deliverable number D7-1
Deliverable Title Application for ethics Compliance and tracer application in humans to the "Bundesamt für Strahlenschutz", including ethics approvals,registration and protocol
WP related number 7Lead beneficiary number
4 -AACHEN
Estimated indicative person-months
6
Nature Dissemination level
R/CONFIDENTIAL
Delivery date (Month) 36
#5 Deliverable number D3-2
Deliverable Title Fully assembled PET ring and performance assessment report
WP related number 3Lead beneficiary number
1-UNIPI
Estimated indicative person-months
100
Nature Dissemination level
R/CONFIDENTIAL
Delivery date (Month) 3036
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#6 Deliverable number D2-1
Deliverable Title Feasibility of advanced schizophrenia diagnosisthrough the proposed multi-modality platform
WP related number 2Lead beneficiary number 6-ZurichEstimated indicative person-months
47
Nature Dissemination level
R/PUBLIC
Delivery date (Month) 36
#7 Deliverable number D4-2
Deliverable Title Performances of the MR systemWP related number 4Lead beneficiary number 11-RS2DEstimated indicative person-months
77
Nature Dissemination level
R/PUBLIC
Delivery date (Month) 3638
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#8Deliverable number D5-1
Deliverable Title Evaluation of PET reconstruction with MR-based attenuationcorrection and post reconstruction biokinetic modeling
WP related number 5Lead beneficiary number 5- TUMEstimated indicative person-months
56
Nature Dissemination level
R/PUBLIC
Delivery date (Month) 40
#9 Deliverable number D6-2
Deliverable Title Imaging Performances of the PET/MR/EEG system
WP related number 6Lead beneficiary number 3- JULICHEstimated indicative person-months
70
Nature Dissemination level
R/PUBLIC
Delivery date (Month) 4042
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#10 Deliverable number D7-2
Deliverable Title Assessment of the results of the clinical trial with multimodal imaging
WP related number 7Lead beneficiary number 4- AACHENEstimated indicative person-months
30
Nature Dissemination level
R/PUBLIC
Delivery date (Month) 40 48
#11 Deliverable number D8.1
Deliverable Title Report on manufacturing capacity plan, market strategy, training and outreach activities
WP related number 8Lead beneficiary number 2- TEIAEstimated indicative person-months
18
Nature Dissemination level
R/CONFIDENTIAL
Delivery date (Month) 48
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D4.1 Magnet and MR coil specifications 12 (ok)D3.1 Characterization of the detector module and on
the compatibility with magnetic fields18
D6.1 Submission of the application to conduct a clinical trial to the"Bundesinstitut fuer Arzneimittel and Medizinprodukte",including ethics approvals,registration and protocol
26
D7,1 Application for ethics Compliance and tracer application in humans to the "Bundesamt für Strahlenschutz", including ethics approvals,registration and protocol
36
D3.2 Fully assembled PET ring and performance assessment report
36
D2,1 Feasibility of advanced schizophrenia diagnosisthrough the proposed multi-modality platform
36
D4.2 Performances of the MR system 38D5,1 Evaluation of PET reconstruction with MR-based
attenuationcorrection and post reconstruction biokinetic modeling
40
D6,2 Imaging Performances of the PET/MR/EEG system 42D7.2 Assessment of the results of the clinical trial with
multimodal imaging48
D8.1 Report on manufacturing capacity plan, market strategy, training and outreach activities
48
SUMMARY OF DELIVERABLES DATE (MONTH)
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BUDGET#1 - GeneralityFinancial reporting (first one after 18 months, i.e., 31 May 2015)
For each partner [Example for R/D, slight differences for management)Direct cost: 100 k€ (to be reported)
ConsumablesEquipmentPersonnel hired on the project (time sheets)Contribution of Personnel from the institution (time sheets)Travel
Indirect cost: 60k€ (not to be reported, just the gross sum)Total expenses for the period: 160k€If everything is fine, EU gives back 75% x160k = 120k€
P.S. - The numbers are different for the large company,i.e. ADVANSID.
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BUDGET#2 (A word of Caution )
To be in the financial reportInvoices must be already payed by 31 May 2015
If expenses are > 375k€ for the period an Audit Certificate must be included before submission of FormC
When all partners have submitted C (inclusive of the Audit certificate if necessary) , the coordinator can fill the financial report that together with the scientific report constitutes the reporting period document.
This document must be submitted to EU within 2 months, i.e. 31 July 2015
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BUDGET#3 (€€€ distribution time scale)If everything is fine, EU will transfer to the coordinator the 75% of all the money spent by the consortium in the first reporting period. (Note that the prepayment is not to be reported)
Expected transfer to the coordinator one month after the submission of the financial report
end August (maybe optimistic)
Expected transfer to the beneficiaries mid-september (maybe optimistic)
The equal percentage scheme that was used for the prepayment can be changed to different percentages for each beneficieries according to their needs and the approval by the EC.
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PublicationsPublication policy has been set (document sent to STC and EC and available on the website):
- Request of authorization from the coordinator- Pdf Copy to the coordinator when published
Up until now only two presentations made on TRIMAGE:- One at PSMR2014 (from Weeroc group on TRIROC, now
submitted to TNS)- A Poster from TEIA/UNIPI/TUM at IEEE_NSS_MIC _2014
Expected quite a few publications this coming year, starting from PSMR2015 conference (18-20 May, Elba Island, Italy)
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WEBSITE
www.trimage.eu
NOW MOVING TO THE NEW TYPE (with personalized username/password)
www.trimage.eu/trimage(please refer to the recent e-mail from George Loudos)
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Thank you for your presence and attention!.....and let’s have a good and productive meeting