1. Generic Metformin TabletsGlycomet (Generic Metformin Tablets) and ExermetXR or Glycomet SR (Metformin Extended ReleaseTablets) are used to treat type 2 diabetes mellitus(non-insulin dependent diabetes) in adults, whendiet and exercise alone does not result in adequatecontrol of blood glucose levels. Generic Metformin isalso used in the treatment of polycystic ovarysyndrome (PCOS). The Swiss Pharmacy, Geneva Switzerland

2. Generic Metformin TabletsChemical Structure (Metformin) The Swiss Pharmacy, Geneva Switzerland 3. Generic Metformin TabletsGeneric Metformin is an oral antihyperglycemicdrug used in the treatment of type 2 diabetes inadults, particularly in overweight patients, whendietary management and exercise alone does notresult in adequate glycaemic control. The Swiss Pharmacy, Geneva Switzerland 4. Generic Metformin TabletsActive IngredientThe active pharmaceutical ingredientcontained in Glycomet, ExermetXR and Glycomet SR is MetforminHydrochloride. The Swiss Pharmacy, Geneva Switzerland 5. Generic Metformin TabletsStrengths and VersionsGeneric Metformin (normal ImmediateRelease) is available in strengths of250mg, 500 mg , 850 mg and 1000 mgas Glycomet Tablets manufactured byUSV Limited .It is also available as an ExtendedRelease (XR or ER) or SustainedRelease, also called Slow Release (SR)version in the form of Exermet XRavailable in strengths of 500 mg and1000 mg manufactured by Cipla Limitedand Glycomet SR manufactured byUSV Limited. The Swiss Pharmacy, Geneva Switzerland 6. Generic Metformin TabletsStrengths and VersionsThe terms XR, ER and SR areequivalent and refer to the same typeof product. There is no difference ineffectiveness between the Normaland the Extended Release GenericMetformin preparations, but the XRversion was introduced mainly tocounteract the most commongastrointestinal side effects. The Swiss Pharmacy, Geneva Switzerland 7. Generic Metformin TabletsRecommended DosageAdult Dosage (Generic Metformin):The normal starting dose of Glycomet tablets(Metformin Hydrochloride tablets) is 500 mg twice aday or 850 mg once a day, given with meals.Dosage increases should be made in increments of500 mg weekly or 850 mg every 2 weeks, up to atotal of 2000 mg per day, given in divided doses.Patients that require additional glycemic control,may be given a maximum daily dose of 2550 mgper day. Doses above 2000 mg may be bettertolerated given three times a day with meals. The Swiss Pharmacy, Geneva Switzerland 8. Generic Metformin TabletsRecommended DosageAdult Dosage (Generic Metformin XR):The usual initial dose for Glycomet SR orExermet XR (Metformin Hydrochloride extended-releasetablets) is 500 mg given orally, once ortwice daily, after meals. Dosage increases shouldbe made in increments of 500 mg weekly, up to amaximum of 2000 mg daily in divided doses. Ifglycemic control is not achieved with maximumrecommended dosages of Metformin 500 mg XR,patients should be switched to conventionalMetformin Hydrochloride tablets and may receive upto a maximum of 2550 mg per day in divided doses. The Swiss Pharmacy, Geneva Switzerland 9. Generic Metformin TabletsContraindicationsGlycomet, Glycomet SR andExermet XR are contraindicated inpatients with the followingconditions:Hypersensitivity to Metformin Hydrochloride orto any inactive ingredient present in themedication.Contraindicated in cases of Renal dysfunction,e.g., serum creatinine 1.5 mg/dL or more inmales, 1.4 mg/dL or more in females or abnormalcreatinine clearance The Swiss Pharmacy, Geneva Switzerland 10. Generic Metformin TabletsContraindicationsGlycomet, Glycomet SR and Exermet XRare contraindicated in patients with thefollowing conditions:Contraindicated in cases of Metabolic acidosis,including Diabetic ketoacidosis with or withoutcoma. Diabetic ketoacidosis should be treated withinsulin.Patients undergoing radiologic studies involvingintravascular administration of iodinated contrastmaterials, because use of such products mayresult in acute alteration of renal function. The Swiss Pharmacy, Geneva Switzerland 11. Generic Metformin TabletsSide Effects of Generic MetforminThe most commonly observed side effectsassociated with the use of Generic Metforminand Generic Metformin XR were Diarrhea,Nausea, Vomiting, Flatulence, Asthenia,Indigestion, Abdominal Discomfort andHeadache.The uncommon side effects include abnormalstools, hypoglycemia, myalgia, lightheaded,dyspnea, nail disorder, rash, sweatingincreased, taste disorder, chest discomfort,chills, flu syndrome, flushing, palpitation. The Swiss Pharmacy, Geneva Switzerland 12. Generic Metformin TabletsSide Effects of Generic MetforminLactic Acidosis:Lactic acidosis is a rare, but serious,metabolic complication that can occur due toMetformin accumulation during treatmentwith Generic Metformin and GenericMetformin XR.When it has occurred with Metformin, it isgenerally accepted that the lactic acidosiswas usually in patients whose conditionscontraindicated the use of Metformin,particularly those with renal impairment. The Swiss Pharmacy, Geneva Switzerland 13. Generic Metformin TabletsWarnings And PrecautionsLactic acidosis is a rare, but serious metaboliccomplication that can occur due to Metforminaccumulation during treatment with Generic Metforminand Generic Metformin XR.Temporarily discontinue Generic Metformin and GenericMetformin XR in patients undergoing radiologic studieswith intravascular administration of iodinated contrastmaterials or any surgical procedures necessitatingrestricted intake of food or fluids.Metformin is known to be substantially excreted by thekidney, and the risk of metformin accumulation and lacticacidosis increases with the degree of impairment of renalfunction. Thus, patients with serum creatinine levels abovethe upper limit of normal for their age should not receiveGeneric Metformin and Generic Metformin XR. The Swiss Pharmacy, Geneva Switzerland 14. Generic Metformin TabletsWarnings And PrecautionsVitamin B12 deficiency: Metformin may lowerVitamin B12 levels. Measure hematologic parametersannually.Before initiating treatment with Generic Metforminand Generic Metformin XR and at least annuallythereafter, assess renal function and verify as normal.Concomitant medication(s) that may affect renalfunction or result in significant hemodynamic changeor may interfere with the disposition of metformin,such as cationic drugs that are eliminated by renaltubular secretion. The Swiss Pharmacy, Geneva Switzerland 15. Generic Metformin TabletsOverdose SymptomsOverdose of Metformin Hydrochloride hasoccurred, including ingestion of amountsgreater than 50 grams.Hypoglycaemia was reported in approximately10% of cases, but no causal association withMetformin Hydrochloride has been established.Lactic acidosis has been reported inapproximately 32% of Metformin overdosecases. The Swiss Pharmacy, Geneva Switzerland 16. Generic Metformin TabletsOverdose TreatmentMetformin HCl is dialysable with aclearance of up to 170 mL/min undergood haemodynamic conditions .Therefore, haemodialysis may be usefulfor removal of accumulated medicinefrom patients in whom Metforminoverdosage is suspected. The Swiss Pharmacy, Geneva Switzerland 17. Generic Metformin TabletsGlycomet and Glycomet SR Tabletsmanufactured by USV LimitedExermet XR Tabletsmanufactured by Cipla LimitedFor more information click here The Swiss Pharmacy, Geneva Switzerland