Genetic Predictors of Weight Loss andWeight Regain After Intensive Lifestyle

Modification,Metformin Treatment,or Standard Care in the Diabetes

Prevention Program

Featured Article:

Linda M. Delahanty, M.S., R.D., Qing Pan, Ph.D., Kathleen A. Jablonski, Ph.D., Karol E. Watson, M.D., Ph.D., Jeanne M. McCaffery, Ph.D., Alan Shuldiner, M.D., Steven E. Kahn, M.B., ChB., William C. Knowler, M.D., Dr.PH, Jose C. Florez, M.D., Ph.D., Paul W. Franks, Ph.D., M.Phil, M.S., FOR THE DIABETES PREVENTION PROGRAM RESEARCH GROUP*

Diabetes Care Volume 35:363–366

February, 2012

Study Objective

• To test genetic associations with weight loss and weight regain in the Diabetes Prevention Program

Delahanty L et al. Diabetes Care 2012;35:363-366

Study Design

• 16 obesity-predisposing SNPs tested for association with short-term (baseline to 6 months) and long-term (baseline to 2 years) weight loss and weight regain (6 months to study end).

Delahanty L et al. Diabetes Care 2012;35:363-366

Delahanty L et al. Diabetes Care 2012;35:363-366

Conclusion

•Genetic information may help identify people who require additional support to maintain reduced weight after clinical intervention 

Delahanty L et al. Diabetes Care 2012;35:363-366