genome to future drug discovery and design in cancer and infectious diseases dr. b.k. malik school...
TRANSCRIPT
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Genome to Future Drug Discovery and Design in Cancer and Infectious
Diseases
Dr. B.K. MalikDr. B.K. Malik
School of Engineering & Technology,School of Engineering & Technology,
Department of BiotechnologyDepartment of Biotechnology
Sharda UniversitySharda University
Greater Noida,UPGreater Noida,UP
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DRUG DISCOVERY AND DEVELOPMENT PROCESS CAN BE DIVIDEDINTO SEVERAL PHASES
Safety
Efficacy
Efficacy
2 years 2 years 4 years Appropriate target? Appropriate selectivity? Prediction of Unanticipated
Human drug SS Toxicity responses
Lack of efficacy in some patients
THE PROCESS OF DRUG DISCOVERY AND DRUG DEVELOPMENT. THROUGHOUT THE
PROCESS THERE ARE ISSUES WHICH HAVE SIGNIFICANT IMPLICATIONS FOR THE
SUCCESS OF THE DRUG
Drug metabolism & toxicity assessment
Phase 1
Phase 2
Phase 3
Lead compound Efficacy & selectivity
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TO DEVELOP A PHARMACOGENOMIC
DATABASES FOR ETIOLOGY, INDICATION,
PREVELANCE,CHEMOTHERAPEUTIC
INDICATIONS, CONTRAINDICATIONS AND
DRUG-DRUG INTERACTIONS WITH A VIEW
TO ESTABLISH THE ROLE OF
PHARMACOGENETIC POLYMORPHISM IN
DIFFERENTIAL DRUG RESPONSE IN
CANCER AND INFECTIOUS DISEASES
WITH SPECIAL REFERENCE TO THE INDIAN
POPULATION.
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DATABASES ADD TO THE KNOWLEDGE OF
DISEASES AND CAN BE USED IN DIFFERENT
WAYS E.g. TO ANALYSE MECHANISMS OR
TO RETRIEVE RETROSPECTIVE AND
PROSPECTIVE INFORMATION ON CLINICAL
PRESENTATION, DISEASE PHENOTYPE,
LONG-TERM PROGNOSIS, AND EFFICACY
OF THERAPEUTIC OPTIONS. THE CLINICAL
INFORMATION MAY BE CRUCIAL FOR THE
DEVELOPMENT OF NEW TREATMENTS
INCLUDING DRUG DESIGN
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PREVELANCE OF TUBERCULOSIS
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Allergy prevalence is increasing across the World, including India.
Rising Industrialization and pollution are among the factors contributing this increase
Currently asthma prevalence in different parts of India varies between 4% and 20%
The increase in air pollution has been blamed for the rise in the prevalence of asthma
The International study on Asthma and Allergies in Children (ISAAC) has also revealed much higher prevalence in developed countries compared to South-East Asia.
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Cancer of the cervix is the most common cancer among Women in developing countries.
Rates for this cancer have been declining in developed countries partly as a result of improved socio-economic circumstances, better access to medical facilities and screening.
Cancer of the cervix is the second most common in Women, comprising 16.6% of all cancers.
It is the most common cancer in black (31.2%) and colored (22.9%)
Second most common in Asian (8.9%) and fourth most common in white Women (2.7%)
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MTb SYSBORG
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DRUG-ACTIVITY QUERY RESULTS
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M Tuberculosis SysBorg
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MODELING OF PROTEINS FOR TUBERCULOSIS
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TargetTemplate
3D STRUCTURE OF Emb A BY MODELLER
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RAMACHANDRAN PLOT
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Active Site of the EmbA Protein
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Docked Structure of EmbA Protein with UDP-GlcNAc
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Emb B PROTEIN MODELING
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3D STRUCTURE OF Emb B BY MODELLER
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RAMACHANDRAN PLOT
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Active Site of the Emb B Protein
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Docked Structure of Emb B Protein with UDP-GlcNAc
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EMB B MUTATED PROTEIN
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3D STRUCTURE OF EMB B PROTEIN BY MODELLER
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RAMACHANDRAN PLOT
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ACTIVE SITE OF THE EMB B MUTATED PROTEIN
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DOCKED STRUCTURE OF EMB B MUTATED PROTEIN WITH UDP-GlcNAc
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Emb C Protein Modeling
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3D Structure of Emb C By Modeller
TemplateTarget
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RAMACHANDRAN PLOT
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Active Site of the Emb C Protein
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Docked Structure of Emb C Protein with UDP-Glc NAC
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MODELING OF PROTEINS FOR DIARRHOEA
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3D Structure of Human Elongation Factor 2 kinase By Modeller
TEMPLATE TARGET
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RAMACHANDRAN PLOT
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Active Site For Elongation Factor-2-kinase Protein
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Docked Structure of Human Elongation Factor-2-kinase Protein with STAUROSPORINE
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HUMAN AFAMIN PRECURSOR PROTEIN MODELING
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3D STRUCTURE OF HUMAN AFAMIN PRECURSOR BY MODELLER
Target Template
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RAMACHANDRAN PLOT
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ACTIVE SITE OF THE HUMAN AFAMIN PRECURSOR PROTEIN
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Docked Structure of Human Afamin Precursor with MALVIDIN (Natural Ligand)
![Page 85: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/85.jpg)
IHA-HUMAN INHIBIN ALPHA CHAIN PRECURSOR-HOMOSAPIENS PROTEIN MODELING
![Page 86: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/86.jpg)
3D STRUCTURE OF IHA-HUMAN INHIBIN ALPHA CHAIN PRECURSOR-HOMOSAPIENS THROUGH MODELLER
![Page 87: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/87.jpg)
RAMACHANDRAN PLOT
![Page 88: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/88.jpg)
Active Site of IHA-HUMAN INHIBIN ALPHA CHAIN PRECURSOR Protein
![Page 89: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/89.jpg)
Docked Structure of Human Inhibin Alpha Chain with LEUTEOLIN (Natural Ligand)
![Page 90: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/90.jpg)
HUMAN LONG CHAIN FATTY ACID-CoA LIGASE 5 PROTEIN MODELING
![Page 91: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/91.jpg)
3D STRUCTURTE OF HUMAN LONG CHAIN FATTY ACID CoA LIGASE 5 BY MODELLER
![Page 92: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/92.jpg)
RAMACHANDRAN PLOT
![Page 93: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/93.jpg)
ACTIVE SITE OF THE HUMAN LONG CHAIN FATTY ACID CoA LIGASE 5
![Page 94: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/94.jpg)
DOCKED STRUCTURE OF HUMAN LONG CHAIN FATTYACID CoA LIGASE 5 PROTEIN WITH
PYRAZINAMIDE
![Page 95: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/95.jpg)
Docked Structure of Human Long Chain fatty acid CoA Ligase 5 Protein with DELPHINIDIN (Natural Ligand)
![Page 96: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/96.jpg)
G-PROTEIN AOUPLED RECEPTRO CHEMR23 PROTEIN MODELING
![Page 97: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/97.jpg)
3D STRUCTURTE OF G-PROTEIN AOUPLED RECEPTRO CHEMR23 PROTEIN BY MODELLER
TARGET TEMPLATE
![Page 98: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/98.jpg)
RAMACHANDRAN PLOT
![Page 99: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/99.jpg)
ACTIVE SITE OF G-PROTEIN AOUPLED RECEPTRO CHEMR23 PROTEIN
![Page 100: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/100.jpg)
DOCKED STRUCTURE OF G-PROTEIN AOUPLED RECEPTRO CHEMR23 PROTEIN WITH AMYLOID
BETA PEPTIDE
![Page 101: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/101.jpg)
Docked Structure of G-PROTEIN AOUPLED RECEPTRO CHEMR23 PROTEIN with CYANIDIN
(Natural Ligand)
![Page 102: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/102.jpg)
MODELLING OF PROTEINS FOR HIV
![Page 103: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/103.jpg)
3D STRUCTURE OF HIV INTEGRASE OBTAINED THROUGH MODELLER
TARGET TEMPALTE
![Page 104: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/104.jpg)
RAMACHANDRAN PLOT
![Page 105: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/105.jpg)
ACTIVE SITE FOR HIV INTEGRASE PROTEIN
![Page 106: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/106.jpg)
DOCKING STRUCTURE OF HIV INTEGRASE PROTEIN WITH FLAVOPIRODOL (Natural Ligand)
![Page 107: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/107.jpg)
DOCKING STRUCTURE OF HIV INTEGRASE PROTEIN WITH QO2793(SMALL PEPTIDE)
![Page 108: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/108.jpg)
MUTATED HIV INTEGRASE
![Page 109: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/109.jpg)
3D STRUCTURE OF MUTATED HIV INTEGRASE
![Page 110: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/110.jpg)
RAMACHANDRAN PLOT
![Page 111: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/111.jpg)
ACTIVE SITE FOR MUTATED HIV INTEGRASE
![Page 112: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/112.jpg)
Docked structure of MUTATED HIV INTEGRASE with FLAVOPIRIDOL (Natural Ligand)
![Page 113: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/113.jpg)
DOCKED STRUCTURE MUTATED HIV INTEGRASE WITH 1QCJB(SMALL PEPTIDE)
![Page 114: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/114.jpg)
GAG-POL POLYPROTEIN
![Page 115: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/115.jpg)
3D STRUCTURE OF GAG-POL POLYPROTEIN BY MODELLER
![Page 116: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/116.jpg)
RAMACHANDRAN PLOT
![Page 117: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/117.jpg)
ACTIVE SITE OF THE GAG-POL POLY PROTEIN
![Page 118: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/118.jpg)
DOCKED STRUCTURE OF GAG-POL POLY PROTEIN WITH RO 31-8959(CHEMICAL LIGAND)
![Page 119: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/119.jpg)
Docked structure of HIV Gag-Pol Polyprotein and 2BDS(SMALL PEPTIDE)
![Page 120: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/120.jpg)
MUTATED GAG-POL POLYPROTEIN
![Page 121: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/121.jpg)
ACTIVE SITE OF THE MUTATED GAG-POL POLY PROTEIN
![Page 122: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/122.jpg)
Docked structure of Mutated HIV Gag-Pol Protein and Abrelix
![Page 123: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/123.jpg)
Docked structure of Mutated HIV Gag-Pol Polyprotein and Q40772(Small Peptide)
![Page 124: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/124.jpg)
MODELING OF PROTEINS FOR NEUROLOGICAL DISORDERS
![Page 125: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/125.jpg)
ACY2_HUMAN ASPARTOACYLASE
![Page 126: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/126.jpg)
3D STRUCTURE OF ACY2_HUMAN ASPARTOACYLASE BY MODELLER
![Page 127: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/127.jpg)
RAMACHANDRAN PLOT
![Page 128: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/128.jpg)
ACTIVE SITE OF THE ACY2_HUMAN ASPARTOACYLASE
![Page 129: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/129.jpg)
DOCKED STRUCTURE OF ACY2_HUMAN ASPARTOACYLASE
WITH D-ASPARTIC ACID
![Page 130: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/130.jpg)
CAH3_HUMAN Carbonic anhydrase Protein Modeling
![Page 131: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/131.jpg)
3D STRUCTURE OF CAH3_HUMAN Carbonic anhydrase Protein BY MODELLER
![Page 132: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/132.jpg)
RAMACHANDRAN PLOT
![Page 133: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/133.jpg)
ACTIVE SITE OF THE CAH3_HUMAN Carbonic anhydrase Protein
![Page 134: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/134.jpg)
DOCKED STRUCTURE OF CAH3_HUMAN Carbonic anhydrase Protein WITH ACETAZOLAMODE
![Page 135: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/135.jpg)
GAMMA-AMINOBUTYRIC ACID(GABA) A RECEPTOR PROTEIN MODELING
![Page 136: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/136.jpg)
3D STRUCTURE OF gamma-aminobutyric acid (GABA) A receptor BY MODELLER
Target Template
![Page 137: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/137.jpg)
RAMACHANDRAN PLOT
![Page 138: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/138.jpg)
ACTIVE SITE OF THE gamma-aminobutyric acid (GABA) A receptor
![Page 139: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/139.jpg)
DOCKED STRUCTURE OF gamma-aminobutyric acid (GABA) A receptor WITH GABACULINE
![Page 140: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/140.jpg)
GLUTAMATE TRANSPORTER
![Page 141: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/141.jpg)
3D STRUCTURE OF GLUTAMATE TRANSPORTER BY MODELLER
![Page 142: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/142.jpg)
RAMACHANDRAN PLOT
![Page 143: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/143.jpg)
ACTIVE SITE OF THE GLUTAMATE TRANSPORTER
![Page 144: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/144.jpg)
DOCKED STRUCTURE OF GLUTAMATE TRANSPORTER WITH LIDOCANE
![Page 145: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/145.jpg)
GBRA6_HUMAN Gamma-aminobutyric-acid receptor alpha-6 subunit precursor
![Page 146: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/146.jpg)
3D STRUCTURE OF GBRA6_HUMAN Gamma-aminobutyric-acid receptor alpha-6 subunit precursor BY MODELLER
![Page 147: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/147.jpg)
RAMACHANDRAN PLOT
![Page 148: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/148.jpg)
ACTIVE SITE OF THE GBRA6_HUMAN Gamma-aminobutyric-acid receptor alpha-6 subunit precursor
![Page 149: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/149.jpg)
DOCKED STRUCTURE OF GBRA6_HUMAN Gamma-aminobutyric-acid receptor alpha-6 subunit precursor WITH
FELBAMATE
![Page 150: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/150.jpg)
MODELING OF PROTEINS FOR BREAST CANCER
![Page 151: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/151.jpg)
TUBULIN BETA-1 CHAIN PROTEIN
![Page 152: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/152.jpg)
3D STRUCTURE OF 2BTOA BY MODELLER
![Page 153: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/153.jpg)
RAMACHANDRAN PLOT
![Page 154: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/154.jpg)
ACTIVE SITE OF THE 2BTOA PROTEIN
![Page 155: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/155.jpg)
DOCKED STRUCTURE OF TUBULIN BETA-1 CHAIN PROTEIN WITH CALPHOSTIN-I (chemsketch)
![Page 156: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/156.jpg)
DOCKED STRUCTURE OF TUBULIN BETA-1 CHAIN PROTEIN WITH 2BDS (small poly-peptide)
![Page 157: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/157.jpg)
MUTATED TUBULIN BETA-1 CHAIN PROTEIN
![Page 158: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/158.jpg)
3D STRUCTURE OF 10FUA BY MODELLER
![Page 159: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/159.jpg)
RAMACHANDRAN PLOT
![Page 160: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/160.jpg)
ACTIVE SITE OF THE 1OFUA PROTEIN
![Page 161: Genome to Future Drug Discovery and Design in Cancer and Infectious Diseases Dr. B.K. Malik School of Engineering & Technology, Department of Biotechnology](https://reader030.vdocuments.net/reader030/viewer/2022013004/56649f585503460f94c7dc04/html5/thumbnails/161.jpg)
DOCKED STRUCTURE OF MUTATED TUBULIN BETA-1 CHAIN PROTEIN WITH CALPHOSTIN-I (chemsketch)
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DOCKED STRUCTURE OF MUTATED TUBULIN BETA-1 CHAIN PROTEIN WITH 2BDS (small poly-peptide)
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CONCLUSION
THE DATABASES MODEL PRESENTED AND APPLIED HERE WILL ALSO BE USEFUL FOR THE ANALYSIS OF THE GENES TO BE FOUND TOGETHER ALL THESE DATABASES ADD CONSIDERABLY TO OUR KNOWLEDGE ABOUT MECHANISMOF ACTION, DRUG-DRUG INTERACTION, IMMUNODEFECIENCIES, GENETICS, AND TREATMENT.
PHARMACOGENOMIC DATA BASES TOOLS CAN BE APPLIEDTO DRUG DEVELOPMENT WITH THE AIM TO INCREASE THE EFFICIENCY OF THE PROCESS AND THE QUALITY OF PRODUCT.
IT MAY BE CONCLUDED THAT MODELS OF PROTEINSOF DIFFERENT DISEASES SHALL HELP IN UNDERSTANDING DISEASE PROCESSES AND DRUG DESIGN.