gis1- k3 - histologi digestive tract

8/19/2019 GIS1- K3 - Histologi Digestive Tract

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HISTOLOGY OFGASTROINTEST

INAL TRACT

dr. Radita NA Gintingdr. Alya Amila Fitrie, M.Kes

Department of HistologyFaculty of Medicine

University of Sumatera Utara


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Lip

alate

!ongue

OralCavity

"sop#agus

Stomac# $%ardia& Fundusand %orpus& ylorus'

Small intestine$Duodenum& (e)unum&*leum'

Large *ntestine $%aecum&Appendi+& %olon&'

Rectum

Anal %anal'

Alimentary Canal

SalivaryGland

Liver

Gall,ladder

ancreas

Glands


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LI - regions

"+ternal aspects is covered /it# t#in s0in

1ermillion 2one !#e pin0 region of t#e lip is covered /it# t#in s0in& devoid s/eat gland and #air follicles

Mucous aspect is covered ,y strati3ed s4uamous non 0eratini5ed ep.

Su, mucosa is composed of dense and looseconnective tissue. !#ey #ave densevasculari5ation

Muscle s0eletal muscle


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LI


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TEETH %ro/n& cervi+& root

Minerali5ed "namel& Dentin&%ementum

eriodonsium Gingiva&Alveolus& eriodontalligament

ulp c#am,er %onnective

tissue& vascular& lymp#&nerve


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ALATE

Hard palate

• strs4uamous0eratini5ed6para0eratini 5ed ep&

irregularcollagenous %!& and,ony s#elf

Soft palate

• strs4uamousnon0eratini5ed ep&dense

irregular%!& minorsalivaryglands& and,ony s#elf

Uvula

• strs4uamousnon0eratini5ed ep&areolar %!&

muscle


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TONG!E

Dorsal surface Lingual papillaeFiliform papillae Str s4uamous0eratini5ed ep

Fungiform papillaeFoliate papillae $degenerate at - yold'

%ircumvalate papillae 1on ",nerglands produces lipase

*ntrinsic and e+trinsic s0eletal muscle


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apila3liformis

apila foliate

apilafungiformis

apila

circumvallate


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TASTE "!#S Sensory organs& perception

of taste. $*n fungiform andcircumvalate papillae' !aste pore 7val structure& composed of

89 : ;9 spindle


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GENERAL STR!CT!RE

MU%7SA "pit#elium&Lamina propria $glands&

lymp# vessel andnodules& ric#ly

vasculari5ed'& Muscularismucosa

SU=MU%7SA %onnective tissue layer

$Dense& irregular3,roelastic %! glands $>'

in oesop#agus n

duodenum',lood?lymp#atic vessels&Su,mucosal ple+us

$Meissner@s'

MUS%ULAR*S "!"RNA Most consist of smoot#muscle /6 myenteric$Aur,acc#@s' ple+us'

S"R7SA ? AD1"N!*!*A*ntraperitoneal serosa

Retroperitonea adventitia


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GENERAL FEAT!RE

BC


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M$%&sa S$'m$%&sa

M$s%$larise(terna

Ser&sa)Adventitisa


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INNER*ATION OF THE #IGESTI*ETRACT

"nteric Nervous SystemMeissner@s su,mucosal ple+us

%ontrolling secretory& mucosal movement& ,loodo/ regulation

Auer,ac#@s myenteric ple+us eristaltic Motility functions

arasympat#etic and Sympat#etic Nerve arasympat#etic

Stimulates peristalsisE in#i,its sp#incter muscleEtriggers secretion

Sympat#etic *n#i,it peristalsisE activate sp#incter muscles


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A!ER"ACH MYENTERICLE+!S


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ESOHAG!S Mucosa

"pit#elium Str s4uamous non0eratini5ed ep& Lamina propria esop#ageal cardiac glands Musc. Mucosa single layer of longitudinally oriented smoot#

muscle

Su,mucosa "sop#ageal glands

Mucous cells Serous cells pepsinogen > lyso5yme

Muscularis e+terna C layers inner circularE outer longitudinal B6- upper s0eletalE B6- mid s0eletal and smoot#E B6- lo/er

smoot# Adventitia6Serosa

F conveys t#e ,olus from orop#aryn+ to stomac#


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"pit#elium

Lamina ropria

Muscularis mucosa

Su,mucosa

M$s%$larisE(terna

Mucosa

"sop#ageal glands

*nner circularlayer

7uter longitudinallayer


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!NCTION


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STOMACH Mucosa

Su,mucosa

Muscularis "+terna

Serosa


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M!COSA OF GASTER

"pit#elium simple columnar ep Mucus layer6visi,le mucusE ,icar,onate ion Gastric pit6Foveola gastrica

Surface lining cells Regenerative6stem cells

Lamina propria

Loose %!& vascular Houses gastric6fundic6o+yntic glands

Surface lining cells Mucous nec0 cells Regenerative $Stem' cells arietal $7+yntic' cells %#ief $2ymogenic' %ells DN"S %ells6AUD6"nteroendocrine6Argentan %ells

Muscularis mucosae - layers inner circularE outer longitudinalE outermost circular

$occasionally'


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SU=MU%7SADense& irregular %!

Ric#ly vasculari5ed n lymp#oidtissue

Su,mucosal ple+us

MUS%ULAR*S "!"RNA*nnermost o,li4ue layer& middlecircular layer& outer longitudinalmuscle layer

Auer,ac#@s myenteric ple+us

S"R7SA !#in& loose %! covered ,y simple

s4uamous ep


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#ISTRI"!TION OF CELL TYEIN F!N#IC GLAN#S

REGION CELL TYPES

ISTHMUS Surface-lining cells and few DNEScells

NECK Mucous neck cells, Stem cells,

arietal cells, and few DNES cells!"SE C#ief cells, occasional arietal

cells, and few DNES cells


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CELLS roduced t#ic0 mucus

layer Apical cellGlycocaly+


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M!CO!S NECK CELLS

%olumnar& resem,le surface<lining cells

roduce s&l$'le m$%$s and

lyso5yme to lu,ricate gastriccontents redominat in pyloric


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ARIETAL -O+YNTIC CELLS

Large& round topyramid


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CHIEF -/YMOGEN CELLS %olumnar /it#,asop#ilic cytoplasm&,asally located nuclei&

apical secretorygranules$0e0sin&1en'

Ric# R"R& Golgi

apparatus& ,ut a fe/lysosomes Microvilli Secretion of

pepsinogen is induced,y ,ot# neural and#ormonal& triggered ,yse%retin ,inding tot#e receptor $in ,asal

cell'


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SMALL INTESTINEModi3cations of t#e Luminal Surface

• !ransversefolds ofsu,mucosaandmucosat#at formsemicircular to #elical

elevations

licae

circulares $valvesofJerc0ring

'

• "pit#eliallycovered&3nger


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*ntestinal Mucosa"pit#elium surface a,sorptive cells&

Go,let %ells& DN"S cells& M $microfold'

cellsLamina propriaForms t#e core of villi !u,ular glands $%rypts of Lie,er0u#n'

> Regenerative cells & anet# cellsMuscularis mucosae *nner circular layerE outer longitudinal

layer *nner layer enter t#e villus and e+tend

t#roug# its core Su,mucosaDense& irregular 3,roelastic %!E ric# in

lymp# and vascular

Muscularis "+terna*nner circular outer lon itudinal smoot#


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SECIFIC FEAT!RES OFSMALL INTESTINE Duodenum

=runner@s $duodenal' glands in su,mucosa

(e)unumlicae circulares $1alves of Jerc0ring'

*leumeyer@s patc#


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#!O#EN!M

(e)unum

*leum


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ORGAN AAKAH INI2


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S!RFACE A"SORTI*E CELLS

!#e mostnumerous

!all cell /it#,asally locatednucleus& ,rus#,order$microvili'& and

cell )unction For terminal

digestion and

a,sorptions of


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GO"LET CELLS Unicellular glands

roducedmucinogen


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M -MICROFOL# CELLS S4uamous li0e cell a,ove t#e lymp#oid

nodule

*mportant for defense mec#anism

ANETH CELLS


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ANETH CELLS Large&

eosinop#ilic&apicalsecretorygranules I

lyso5yme yramid


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LARGE INTESTINE Appendi+

%aecum and %olon

Rectum and Anal %anal


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AEN#I+ Mucosa

"pit#elium simple columnar Surface a,sorptive cells& go,let cells& M cells

Lamina propria Loose %! Lymp#oid nodules S#allo/ crypts of Lie,er0u#n

Surface a,sorptive& go,let & regenerative& DN"S& and anet#%ells

Su,mucosa& Muscularis e+terna& Serosa

Stellate l$men t3at is 4lled 'y de'ris


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CAEC!M AN# COLON Mucosa

"pit#elium simple columnar Lamina propria

Ric#ly endo/ed crypt#s of Lie,er0u#n No anet# cellsE surface a,sorptive cells Go,let

cells & DN"S

Su,mucosa Muscularis e+terna

C layers inner circularE outer longitudinal7uter longitudinal layer is not continous ,ut is gat#ered

into - fascicles taenia coli Serosa

Appendices epiploicae fat


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!aenia %oli


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ANAL CANAL Mucosa

"pit#elium simple cu,oidal from rectum to pectinate line Str s4uamous non0eratini5ed from pectinate line to e+ternal

anal ori3ce Str s4uamous 0eratini5ed epidermis at anus

Lamina propria #ouses anal glands $at rectoanal )unction' and circumanal glands $distal end of anal canal' Su,mucosa

Fi,roelastic tissue #ouses C venous ple+us internal ande+ternal #emorr#oidal ple+us

Muscularis e+terna *nner circular layer ,ecomes t#ic0ened at pectinate line

to form internal anal sp#incter muscle"+ternal anal sp#icter muscle comes from pelvis


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!#an0

gis1- k3 - histologi digestive tract

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