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Approach to Approach to Gastrointestinal Gastrointestinal
BleedingBleeding
Approach to Approach to Gastrointestinal Gastrointestinal
BleedingBleeding
Introduction/Epidemiology
Gastrointestinal Bleeding is a common problem in emergency medicine
Mortality is approximately 5 - 10 % with a decrease in the past 15 years.
Vocabulary
Gastrointestinal bleeding comprises Upper & Lower Gastrointestinal bleeding– The difference is defined by location of
source of bleeding - – Either proximal or distal to the ligament of
Treitz (duodenal suspensory ligament that attaches at the junction of duodenum and jejunum)
Prehospital Treatment
Based on patient’s hemodynamic status
If any signs of shock/unstable gastrointestinal bleeding the priorty is rapid transport
Brief initial survey to include airway,breathing, circulation, & mechanism of injury
Prehospital Evaluation
Look for signs of hemorrhagic shock
– Altered mental status
– Cool,clammy skin
– Increased capillary Fill time
– Tachycardia
– Hypotension
Prehospital Treatment
Intubate unresponsive patients & those unable to protect their airway
Transport in Trendelenburg’s position & on left side
No extra time at the scene should be spent establishing intravenous access in unstable patients– Large bore lines should be placed en
route
Prehospital Evaluation
If objective findings of bleeding at the scene - document the amount of blood
If time permits- utilize friends, family, or neighbors for brief history
Transport any medical records or medications if available
Emergency DepartmentTreatment & Evaluation
Regardless of presentation
Require Immediate Resuscitation & Stabilization– Monitor oxygenation with pulse oximetry
Unstable patients require 2 large bore intravenous lines, cardiac monitoring, & frequent vital sign checks
Emergency Department Evaluation &Treatment
Resuscitate using Lactated Ringer’s or Normal Saline - Use boluses from 250 ml to 1000 ml in order to maintain systolic blood pressure above 90 mm Hg
If response is inadequate after 2-3 liters of crystalloid - consider blood transfusions
Emergency Department Management
A nasogastric tube should be placed in all patients with significant gastrointestinal bleeding regardless of presumed source.
Gastric Lavage
– Using large-bore tube
– Room temperature saline should be used.
Emergency Department Management
Transfusions
– Packed Red Blood Cells (PRBC’s)
– Fresh Frozen Plasma (FFP)
– Platelet Transfusions
Clinical Manifestations
GI Bleeding most commonly presents with hematemesis, Coffee-ground emesis, melena or hematochezia.– Hematemesis/coffee-ground emesis
suggests upper GI bleeding.– Melena suggests a source at or proximal
to right colon.– Hematochezia suggests a more distal
colorectal lesion.
GI Bleeding History
Weight loss or changes in bowel habits are classic symptoms of malignancy.
Vomiting or retching is suggestive of a Mallory-Weiss tear.
History of medications should be sought. Alcohol abuse/dependence is strongly
associated with GI bleeding.
Physical Examination
Vital Signs
Skin Findings
A careful ENT examination
Abdominal Examination
Rectal Examination
Initial Diagnostic Studies
Laboratory
– Most important test is to Type & Cross-match for 4-6 units of Packed Red Blood Cells (PRBC’s)
– CBC with platelets
– Coagulation Studies
– Electrolytes, Calcium, BUN, Creatinine, & Glucose & Liver Function Tests.
Initial Diagnostic Studies
Obtain ECG in patients over 40 years old.
Radiography
– Upright Chest X-Ray
– Abdominal Films- Flat, Upright, or Decubitus
Secondary Management
Endoscopy
Drug Therapy
Balloon Tamponade
Surgery
Upper GI Bleeding
• Hematemesis implies an upper GI source. • Symptoms of anemia• The location of pain can be helpful.
Worsened pain and acute GI bleeding: trauma, pancreatitis, or hematobilia.
• Important questions include symptoms, use of alcohol, NSAIDs, anticoagulants, abdominal
trauma, prior Gl bleeding, family history of GI bleeding, recent non-intestinal GI bleeding. • Previous blood transfusions or reactions to them
H I S T O R Y
PHYSICAL EXAMINATIONS
Always document signs indicative of major GI hemorrhage
• Signs of anemia• Supine hypotension • Resting tachycardia • Positive "tilt" test• Peripheral vasoconstriction • Altered mental status • Oliguria. • Look for a nasopharyngeal source • Evidence of portal hypertension• Abdominal surgical scars
DIFFERENTIAL DIAGNOSIS
If hematemesis is present, rule out:
• nasopharyngeal sources:chronic inflammation, polyp, malignancy
• pulmonary sources:tuberculosis, pneumonia, bronkiectasi
• coagulopathy:D.I.C, hemophilia
LABORATORY TESTS
• CBC, coagulation factors, and fibrinolysis.
• LFT, kidney functions
• Plain x-rays of the abdomen, if a viscus
perforation is suspected.
• Endoscopic examination
NASOGASTRIC TUBE
• Regardless of a positive or negative NGT aspirate, if lower vs. upper bleed is
uncertain, leave the tube in for 12-24 hours to detect a rebleed or duodenal reflux of blood.
• A negative NGT does not rule out an upper
GI bleed
All GI bleeders should have a nasogastric tube (NGT) placed
CAUSES
Most common:
40-60%
20-35%
8-15%
8-15%
Peptic Ulcer Disease
Gastritis
Varicies
Mallory-Weiss
Less Common:
Gastric Malignancy Chronic Renal Failure Angiodysplasia of stomach/duodenum Esophagitis Duodenitis Pancreatitis, Pancreatic Neoplasm Leukemias, DIC, Thrombocytopenia
CAUSES
Rare Causes:
Leiomyoma, leiomyosarcoma Aorto-enteric fistula Hemobilia Duodenal diverticula Collagen Vascular Diseases Mucocutaneous syndromes Osler-Weber-Rendu, Peutz-Jeghers
CAUSES OF UPPER GI BLEEDING (cont’d)
ALGORITHM FOR ACUTE GI BLEEDING
Patient presents with acute GI bleeding- Evaluate ABC- Determine past or current bleeding- Draw blood for CBC, PT, aPTT, crossmatch
Stable Unstable- Give oxygen by mask- IV catheter- Insert Foley catheter - Give blood as needed- Correct coagulopathy
Stabilized Remain unstable:Surgical approach
- H & PE- NG aspirate/lavage- Identify prognostic factors- Endoscopy
Summary
Regardless of presentation, begin
with immediate resuscitation and
stabilization.