Global Manufacturing & Supply

Our agenda today

1. About GlaxoSmithKline, Global Manufacturing and Supply (GMS) and

biopharmaceutical production within GMS

2. Future Leader Program in Global Manufacturing and Supply

3. Should I apply?

4. How do I apply?

5. Any questions?

Do more, feel better, live longer

We are a science-led global healthcare company, making a range of products that help people do more, feel better and live longer. Our commercial success depends on creating innovative new products and making these accessible to as many people who need them as possible.

Pharmaceuticals Vaccines Consumer Healthcare

Respiratory disease, cancer,

heart disease, epilepsy, HIV ,

lupus, and skin conditions like

psoriasis.

Influenza, rotavirus, cervical

cancer, measles, mumps, rubella,

hepatitis, polio, tetanus and

meningitis.

Wellness, Skin Health, Oral

Health and Nutrition.

Our portfolio includes well-known

brands such as: Horlicks, Panadol

and Sensodyne.

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Manufacture the products that enable people to do more, feel better and live longer

Ensure the delivery of quality and value to the patient at the end of the Supply Chain

In Global Manufacturing and Supply we:

Types of Pharmaceutical Compounds

• Small Molecules

– “Traditional” pharmaceutical compounds

– Chemically produced, defined

Types of Biopharmaceuticals:

• Vaccines

• Therapeutic Proteins

– Monoclonal antibodies (MAb)

– MAb-derivatives (e.g. domain antibodies)

– Conjugated peptides

CDC Public Health

Information Library

Biopharmaceuticals within GSK

• Biopharm products are now over 20% of GSK’s pipeline

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GSK is committed to the development of biopharmaceutical products

Compound Types Indication

2862277 tumour necrosis factor receptor-1 (TNFR1) domain

antibody acute lung injury

sirukumab IL6 human monoclonal antibody rheumatoid arthritis

2398852 SAP monoclonal antibody cancer

3052230 fibroblast growth factor ligand trap cancer

249320 myelin-associated glycoprotein monoclonal antibody stroke

2586881 recombinant human angiotensin converting enzyme 2 acute lung injury

933776 beta amyloid monoclonal antibody geographic retinal atrophy

3196165 granulocyte macrophage colony stimulating factor

monoclonal antibody rheumatoid arthritis

ozanezumab neurite outgrowth inhibitor (NOGO-A) monoclonal

antibody amyotrophic lateral sclerosis

Arzerra (ofatumumab) CD20 human monoclonal antibody

chronic lymphocytic leukaemia, first line therapy &

use in relapsed patients; diffuse large B cell

lymphoma (relapsed patients); follicular lymphoma

(refractory & relapsed patients); multiple sclerosis

Benlysta (belimumab) B lymphocyte stimulator monoclonal antibody

systemic lupus erythematosus; vasculitis;

ideopathic memembranous nephropathy;

myasthenia gravis

mepolizumab IL5 monoclonal antibody severe asthma; nasal polyposis

Tanzeum (albiglutide) GLP 1 agonist type 2 diabetes

raxibacumab protective antigen inhibitor inhalation anthrax

2618960 IL7 receptor monoclonal antibody autoimmune disease

GSK Biopharmaceutical Production

• GSK’s fully integrated Biopharmaceutical Supply Chain

– Primary Production in Upper Merion PA and Rockville MD

• Biosynthesis (cell culture or fermentation) and purification

– Secondary Production in Barnard Castle UK and Parma Italy

• Final formulation and aseptic filling

Upper Merion

Rockville

Parma Barnard Castle

Located in King of Prussia, a suburb of Philadelphia, PA.

100,000 ft2 of production space and 240,000ft2 total footprint.

Staffed by approximately 240 people, 24/7 operation.

Site constructed in 1997. Cell Culture Value Stream added in 2005. Full retrofit creating Microbial Value Stream in 2010

Biopharmaceutical Primary Production

Upper Merion

Located in the suburbs of Baltimore, MD and Washington, DC.

Large Scale Manufacturing (LSM): 80,000 ft2 of production space and 290,000ft2 total footprint.

Small Scale Manufacturing (SSM): 130,000 ft2 total footprint.

Biopharmaceutical Primary Production

Rockville

Biopharmaceutical Secondary Production Barnard Castle UK and Parma Italy

Liquids & Freeze Dry Products Clinical and commercial capacity

Recognized world-class sites in quality, technology, and controls

Multiple formats (vials, syringes) and dose ranges (0.5 mL – 100 mL)

Large lyophilization and overall capacity

The Future Leader Programme in Global Manufacturing & Supply

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On the job development

through challenging roles

Formal training programmes and

structured assessment

Multiple rotations across/within

functions ensure early breadth of

technical experience

Senior leadership, mentoring/ buddy,

coaching and support

Future Leaders Programme characteristics

Program Objectives

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Attract and retain the best technical graduates

Accelerate development of top technical talent for key manufacturing and supply areas

Provide a robust technical career foundation, with the ability to spot emerging leadership and adapt the development accordingly.

Global Manufacturing and Supply

Future Leaders Programme

• This is a unique opportunity to gain a broad range of experience in

biopharmaceutical production and learn from experts

• 3 Rotations in different sites or parts of our business (with the potential for

international assignment)

• 3 Year Development Program

• Target of 50 recruits per year, globally

• Development Framework:

– Technical Expertise

– Business Execution

– Leadership Expectations

– Personal Skills

Program Structure

Start Date 16 months 18 months 8 months

360

Manager

Expectation

Setting

Energy4Performance

Harvard

ManageMentor

Practical Coaching in

the Workplace

ADP

Coaching and/or Mentoring and Buddying

Review

Point

70

20

10

Development

Web Pages

1

Rotation

2

Rotation

3

Rotation Rotation

Regular 1-to-1s, feedback and Performance and Development Plan conversations

GSK Global curriculum, tools and resources to be included as appropriate:

Review

Point

Tra

nsitio

n to

Bu

sin

ess, p

en

din

g p

erfo

rma

nce

and

busin

ess n

ee

ds

Alu

mn

i pro

gre

ssio

n tra

cke

d &

deve

lope

d

Graduate

Community

Intranet

Specific Technical Training

Fundamentals of

Leadership

First Line Leader

Management

Essentials

Interpersonal Skills

Module Personal Skills Module Joining GSK

12 months

September

January

January

August

What Might I Do or Learn during Rotations?

Engineering and Science are the Core of Our Business

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• Technology transfer

• Participate/Lead production deviation investigations

• Analyze manufacturing data

• Implementation of new manufacturing technology

• Process improvement projects

• Process development

• Process validation

• Technical writing

What Type of Work Would I Do After the Rotations?

Engineering and Science are the Core of Our Business

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• Product Owners

– Responsible for technical governance of our

products and maintenance of the product control

strategy

• Process Engineers & Platform Experts

– Experts in the interaction between process

equipment and the product

• Technologists

– Scientific graduates who are responsible for

executing key technical activities including trials,

improvement projects, root cause analysis,

validation, report writing etc.

Development on the placement 7

0%

On the job d

evelo

pm

ent • Delivery of

projects

• Ad hoc support of additional projects for the host team

• Development of technical skills through doing

• Development of and awareness of High Performance Behaviours

• Completion of Performance and Development Planto track development

20%

Learn

fro

m o

thers

• Shadowing opportunities

• Mentors

• Buddy system

• Peers

• Networking

• Induction opportunities to areas outside the host team of the participant

10

% F

orm

al develo

pm

ent • Specific Technical

or Supply Chain Training

• Harvard Manage Mentor

• Site visits (where appropriate)

• GSK Experience

• Fundamentals of Leadership

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Meet Our Graduates!

Alicia’s Video

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Engineering at GSK

00 Month 0000 Presentation title in footer

Watch Alicia’s video!

Should I apply?

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What do you need to apply?

23 00 Month 0000 Presentation title in footer

• Do you have an engineering or science degree with strong credentials

(i.e., GPA >3.5; preference for MS or PhD candidates)?

• Applicants must hold a full US work permit for this program

• Do you have strengths in communication, influencing, teamwork and

problem-solving?

• Do you want to help people to do more, feel better and live longer?

• Do you demonstrate GSK’s values?

How do I apply?

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The Application Process

• Online application form

– Do you have the right degree background?

– Why do you want to work at GSK?

• Phone Interview

• Assessment Centre

- Technical Assessment

- Competency Assessment

- Group Assessment

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What does it involve?

Applications open

Sep 2014

Virtual / Telephone Interviews

Technical and behavioural assessment

Assessment Centre

Technical and behavioural assessment

Nov 2014

Offer

We look to offer within 2 weeks

Join GSK

Dec 2014 or

Sep 2015

Apply online http://gskbigquestions.com/

For additional information http://us.gsk.com/en-us/careers/undergraduates/future-

leaders-us-technical-development/

Join the conversation

Any questions?

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