glucosamina coindritina
TRANSCRIPT
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GLUCOSAMINA - COINDRITINA
Dra. Madeline Bilbao RodasR1 Ortopedia y Traumatología
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GENERALIDADES• Precursor de la glicosilación de proteínas y lípidos• Suplemento nutricional
• No es regulado por la FDA• Proviene de los caparazones de crustáceos• Uso en osteoartrosis
• $ 730 millones
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Formación de cartílago
https://commons.wikimedia.org/wiki/File:Glycosaminoglycans.jpg
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DOS FORMAS• Sulfato de glucosamina
• 74% de pureza• Hidroclorato de glucosamina
• 99% pureza
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FARMACOLOGÍA• LATENCIA: 4 A 8 SEMANAS• BIODISPONIBILIDAD: 26%• VIDA MEDIA 58 HORAS• EFECTO PRIMER PASO
• SE ABOSRBE BIEN • ELIMINACIÓN: RENAL - FECAL
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FARMACOCINÉTICA• MECANISMO DE ACCIÓN SE DESCONOCE• SUSTRATO PARA LA SÍNTESIS DE
MUCOPOLISACÁRIDOS• AUMENTA
• AGRECAN Y COLÁGENO • ANTIINFLAMATORIO?
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Meulyzer M, Vachon P, Beaudry F, Vinardell T, Richard H, Beauchamp G, et al. Comparison of pharmacokinetics of glucosamine and synovial fluid levels following administration of glucosamine sulphate or glucosamine hydrochloride. Osteoarthr Cartil. 2008;16(9):973–9.
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BIBLIOGRAFÍA• Kirkham, SG, Samarasinghe RK. Review article: Glucosamine. Journal of Orthopaedic
Surgery 2009;17(1):72-6
• •