glucose sensing system - kathryn dipippo · internal mobilization of in vivo glucose sensing system...

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Internal Mobilization of in vivo Glucose Sensing System 1 Princeton University Department of Electrical Engineering, Princeton, NJ, 08540, USA 2 Permanent Address: Rensselaer Polytechnic Institute, Troy, NY, 12180, USA 3 Permanent Address: Bucknell University, Lewisberg, PA, 17837, USA 4 Permanent Address: Hunterdon Central Regional High School, Flemington, NJ, 08822, USA Kathryn DiPippo 1,2 , Sabbir Liakat 1 , Phillip Heucke 1,3 , Jessica Doyle 1,4 , and Claire Gmachl 1 email: [email protected] / [email protected] GOAL: Mobilize glucose sensor by… 1) Creating and Optimizing a MatLab GUI 2) Optimizing outlier removal algorithm 1) Reducing the size of the Mid- Infrared Integrating Sphere (mIRIS)

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Page 1: Glucose Sensing System - Kathryn DiPippo · Internal Mobilization of in vivo Glucose Sensing System 1 Princeton University Department of Electrical Engineering, Princeton, NJ, 08540,

Internal Mobilization of in vivo Glucose Sensing System

1 Princeton University Department of Electrical Engineering, Princeton, NJ, 08540, USA 2 Permanent Address: Rensselaer Polytechnic Institute, Troy, NY, 12180, USA 3 Permanent Address: Bucknell University, Lewisberg, PA, 17837, USA 4 Permanent Address: Hunterdon Central Regional High School, Flemington, NJ, 08822, USA

Kathryn DiPippo1,2, Sabbir Liakat1, Phillip Heucke1,3, Jessica Doyle1,4, and Claire Gmachl1

email: [email protected] / [email protected] GOAL: Mobilize glucose sensor by…

1) Creating and Optimizing a MatLab GUI

2) Optimizing outlier

removal algorithm

1) Reducing the size of the Mid-Infrared Integrating Sphere (mIRIS)

Page 2: Glucose Sensing System - Kathryn DiPippo · Internal Mobilization of in vivo Glucose Sensing System 1 Princeton University Department of Electrical Engineering, Princeton, NJ, 08540,

Creation and Optimization of GUI

Outlier Removal

Cross-Correlate with Standard

Savitzky-Golay Filtering

Take First Derivative

(1) Connection Status Indicators

(2) Easily input variables

(3) Graphical Display

PLSR

Page 3: Glucose Sensing System - Kathryn DiPippo · Internal Mobilization of in vivo Glucose Sensing System 1 Princeton University Department of Electrical Engineering, Princeton, NJ, 08540,

“Real-Time” Outlier Correction

With Outliers

Modified Data

Previous method and problems • Cut-off after largest spike • Doesn’t account for early

outliers Current method and advantages

Glucose Absorption Spectra

Page 4: Glucose Sensing System - Kathryn DiPippo · Internal Mobilization of in vivo Glucose Sensing System 1 Princeton University Department of Electrical Engineering, Princeton, NJ, 08540,

Optimization of Mid-Infrared Integration Sphere (mIRIS)

Current size: Cube: 3.27” x 3.27” x 3.25” Sphere: 3” diameter Holes: 2.0 cm diameter

New Prospective Size: Cube: 8.3mm3

Sphere: 7.6mm diameter Holes: 2.0mm diameter

Device Aperture Sizes: Hand: 1.0mm diameter Laser: 1.2mm diameter Detector: 0.50mm x 0.50mm

Page 5: Glucose Sensing System - Kathryn DiPippo · Internal Mobilization of in vivo Glucose Sensing System 1 Princeton University Department of Electrical Engineering, Princeton, NJ, 08540,

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