glycoproducts for life sciences - elicityl contact us for bulk quantities - [email protected] -...

www.elicityl-oligotech.com Contact us for bulk quantities - [email protected] - +33 (0) 4 76 40 71 61 3

Glycoproducts for life sciences Engineering and production

OligoTech

Key to catalog reading

GLY022 Lacto-N-neohexaose LNnH

Gal -4GlcNAc -3Gal -4GlcNAc - Gal -4Glc C40H68N2O31

FW 1072 [64003-52-7]

Human Milk Oligosaccharide Kunz et al., 2000. Ann Rev Nutr. 20, 699-722 5 mg, 25 mg, 100 mg, 1 g, 5 g

AcNHO

OHO

O

OH

OH

HO O

O

OHOH

OHOH

O

OH

OHO OH

AcNHO

OHO

O

OH

HO

OH

OH

HO O

OH

1 2

3

4

7

8

9

5

106

1 Product Code

2

3

4

Product Name

Synonym or Acronym

Text Formula

5 Structure

6 Reference

7

8

9

Formula

Formula Weight

Cas Number

10 Typical pack size

®

INTERIEUR Catalogue OligoTech 2012.pdf 1 13/06/12 8:01:09



Table of contents

Key to catalogue reading 3 About OligoTech® - Catalogue, customized delivery and services 6 Products 11 Product Code Index 162

Product Name Index 165

Sale Terms and conditions 17

Products

Natural polysaccharides and oligosaccharides extracted from biomass 11

Glucan 113 Xyloglucan Cellodextrin / Maltodextrin Laminaran Lichenan / Isolichenan Scleroglucan Lentinan Pustulan

14 20 26 28 30 31 32

Xanthan 333 33 Chitin / Chitosan 335 35 Ulvan 441 41 Fucoidan / Galactofucan 445 45 Xylan 449 49 Galactan 553 Arabinogalactan

Carrageenan Agar

54 56 58

Mannan 559 Mannan Xylomannan Galactomannan Glucomannan Galactoglucomannan

60 62 63 66 68

Alginate 669 69 Galacturonan / Apiogalacturonan 775 75 Arabinan 779 79 Fructan 881 Inulin 82 Spirulan 885 85 Heteroglycan 887 87


5



Glycan oligosaccharides 89

Core structures

993 Type 1 Type 4 Type 2

93 94 94

Blood groups and Lewis antigens

996 H (O )antigens A antigens B antigens Lewis antigens

97 99 102 105

Fucosylated oligosaccharides

1099 Lacto-series 3 Fucosyllactose core oligosaccharides

109 110

Galα--3 oligosaccharides

1112

Galili and xeno antigens Isoglobo-series

112 114

Sialylated oligosaccharides

1155 Type 1 Type 2

115 116

Ganglioside sugars (Ganglio--Series) 1188 118 Globo--series ((P antigens) 1233 P blood group antigens and analogues

Globo-series Stage-Specific Embryonic antigens Forssman antigens

124 125 126 127

Glucuronylated oligosaccharides 1288 128 Miscellaneous

1299 Trehalose-like sugars Blood-group-related antigens Globo-series analogues IsoGlobo-series analogues Ganglio-series antigens analogues

129 130 130 133 136

Monosaccharides, di-, tri, tetrasaccharides 137

GlycoBricks®: Functionalized Glycans 141

Glycosaminoglycans 151

Heparosan & DDerived Oligosaccharides

1522 Heparosan K5 polysaccharide Heparosan-Derived oligosaccharides

152 153

Aminoglycoside derivatives 155

Human & Bacterial Lectins 157




About OligoTech®

Catalogue, customized delivery and services

Mission Elicityl is a biotech company specialized in carbohydrate engineering and production that offers a wide and unique collection of glycoproducts for research, development and for industrial applications. Elicityl provides a wide range of products and services for the rapidly growing field of research and innovation in glycosciences through the OligoTech®. Elicityl is customer-oriented and we evaluate all specific demand to accompany your project. We use the appropriate methodologies of purification, characterization and quality control to guarantee that our products meet customer needs. Our original technology of production allows getting available specific carbohydrates in large quantities at competitive cost.

OligoTech®: Glycoproducts for life sciences The OligoTech® catalogue includes over 400 products for glycosciences and in particular for biomedical, phytopharmaceutical, cosmetics and nutraceutics R&D.

Natural polysaccharides and oligosaccharides extracted from biomass

Glycan oligosaccharides

Monosaccharides, di-, tri-, tetrasaccharides

Glycobricks®: Functionalized Glycans

Glycosaminoglycans

Aminoglycoside derivatives

Lectins

Bulk quantities are available on specific demand.




The OligoTech® offer

Analysis services Natural carbohydrate characterization & identification Purification of samples for analysis Structure, monomer composition, sulfation… Purity determination

Customized delivery Feasibility study Customized production Production from the g, 100 g and multi kg scale For development and/or production of specific needs Targeted selections of carbohydrates for screening Affinity adsorbents Immobilizable oligosaccharides for spotting Glycan array

Catalogue Unique offer of Glycoproducts Reagents for research Order on-line –NEW-


OligoTech®




OligoTech® know-how & capabilities Elicityl supplies carbohydrates and glycoproducts manufactured in our facilities by

extraction, enzymatic processes and fermentation.

Elicityl develops industrial methods of production based on its expertise in carbohydrate elaboration, purification and characterization.

Analysis and quality control

Elicityl develops standardized production processes in a QA/QC policy allowing reproducibility and traceability of production batches.

The products supplied are consistent with internal standards. They are analysed by

adapted and efficient technologies such as HPLC, HPAEC, NMR, Mass spectrometry or SEC.

Production traceability is guaranteed by individual production dossier for each Product.

Storage of reference samples at Elicityl for each batch of production.

Production processes are consistent with ISO9001 procedures.

Each product is supplied with its Certificate of Analysis.


OligoTech®




Elicityl distinctive points Process know-how, development and production lines fully owned by Elicityl.

Exclusive license agreements for the exploitation of innovative technologies for large scale

oligosaccharide production.

Products available in large quantities.

Cooperative expertise network and partnerships for biological activity screening programs.

Selections of carbohydrates available in large quantities:

Human milk oligosaccharides (HMOs)

Tumor-associated carbohydrate antigens (TACAs)

Histo-blood group antigens (ABH, Lewis and P systems)

Cosmetic applications following INCI

Flexibility

Confidentiality

Distribution Elicityl’s OligoTech® is distributed in Japan by Ikeda Scientific (www.ikedarika.co.jp).


OligoTech®



OOligoTech®®

Extraction from Biomass

Natural Polysaccharides & Oligosaccharides



OOligoTech®®

www.elicityl-oligoContact us for bulk quantities - contact@e



OOligoTech®®

GGlucan Extraction from biomass

Xyloglucan Cellodextrin / Maltodextrin

Laminaran Lichenan / Isolichenan

Scleroglucan Lentinan Pustulan



OOligoTech®®


Xyloglucan

ACTIVITIES AND USES

Xyloglucan is a source of biologically active oligosaccharides and polysaccharides. They have been shown to control plant development and metabolism. Oligosaccharides issued from apple and tamarind are considered as biofertilizers and elicitors of plant defences (Elicityl Patents). Additionally, Xyloglucans were indicated to possess immunomodulatory activity (Rosário MM et al., Phytochemistry. 2008 Jan; 69(2):464-72) and are also likely to be used as immunoprotective ingredients in sun creams.

Recommended paper: A. Lama-Muñoz et al. Food Hydrocolloids 28 (2012) 92-104

POSSIBLE BIOMASS SOURCE(S)

Apple Tamarind Bilberry Olive fruit…

STRUCTURAL DESCRIPTION

Xyloglucans are hemicellulosic polysaccharides present in the primary cell walls of all types of higher plants. Xyloglucans consist of a β-D-(1-4) glucan backbone with α-D-xylosyl residues attached to the 6-position of approximatively 75% of the glucosyl residues of the backbone. Some of the α-D-xylosyl residues are themselves substituted at the 2-position with -galactosyl or α(1-2) Fucosyl-β(1-2) galactosyl moieties.

Xyloglucan oligosaccharides nomenclature according Fry et al. Plant Physiol. 1993 103:1-5.

β-D-Glc

α-D-Xyl 1 ↓ 6

β-D-Glc

β-D-Gal 1 ↓ 2

α-D-Xyl 1 ↓ 6

β-D-Glc

α-L-Fuc 1 ↓ 2

β-D-Gal 1 ↓ 2

α-D-Xyl 1 ↓ 6

β-D-Glc

α-L-Gal 1 ↓ 2

β-D-Gal 1 ↓ 2

α-D-Xyl 1 ↓ 6

β-D-Glc

α-L-Ara 1 ↓ 2

α-D-Xyl 1 ↓ 6

β-D-Glc

β-L-Ara 1 ↓ 2

α-L-Ara 1 ↓ 2

α-D-Xyl 1 ↓ 6

β-D-Glc

α-D-Xyl 1 ↓ 6

β-D-Glc 2 ↑ 1

α-L-Ara

α-D-Xyl 1 ↓ 6

β-D-Glc 2 ↑ 1

β-D-Xyl

α-D-Xyl 1 ↓ 6

β-D-Glc 2 ↑ 1

β-D-Xyl 3 ↑ 1

α-L-Ara

D-Glcol

G X L F J S T A B C Gol



OOligoTech®®

This group of fucosylated Xyloglucan oligosaccharides is produced by enzymatic engineering and is extracted from apple. Each product is purified by semi-preparative HPLC.


Xyloglucan

GLU1000 Xyloglucan oligosaccharides 100% xyloglucan oligosaccharides extracted and purified from apple.

Obtained through enzymatic clivage and Solid Phase Extraction Chromatography.

100 mg, 1 g, 10 g

GLU1110 XFG xyloglucan oligosaccharide (DP7) 100% xyloglucan oligosaccharides containing almost 80% of

XFG. Reducing end.

C40H68O33 FW 1076.94

Product provided for the following study : Audfray et al., 2012. Fucose-binding Lectin from Opportunistic Pathogen Burkholderia ambifaria binds to both Plant and Human Oligosaccharidic Epitopes. Journal of Biol. Chem, vol 287. N°6. 10 mg, 100 mg, 1 g

GLU1111 Reduced XFG xyloglucan oligosaccharide (DP7) XFGol

100% xyloglucan oligosaccharides containing almost 80% of reduced XFG (XFGol).

C40H70O33 FW 1078.95

[870721-81-6]

10 mg, 100 mg, 1 g

α-D-Xyl 1 ↓ 6

α-L-Fuc

1 ↓ 2

β-D-Gal 1 ↓ 2

α-D-Xyl 1 ↓ 6

β-D-Glc1→4β-D-Glc1→4β-D-Glc

X F G

α-D-Xyl 1 ↓ 6

α-L-Fuc

1 ↓ 2

β-D-Gal 1 ↓ 2

α-D-Xyl 1 ↓ 6

β-D-Glc1→4β-D-Glc1→4β-D-Gol

X F Gol



OOligoTech®®

GLU1112 Acetylated XFG xyloglucan oligosaccharide (DP7) XFG(Ac)

100% xyloglucan oligosaccharides containing almost 80% of mono-acetylated and non-reduced XFG or XFG(Ac). Mono acetylation occurs on the galactosyl residue.

C42H70O34 FW 1118.98

10 mg, 100 mg, 1 g

GLU1160 XLFG xyloglucan oligosaccharide (DP10)

100% xyloglucan oligosaccharides containing almost 60% of XLFG. Reducing end.

C57H96O47 FW 1533.33

10 mg, 100 mg, 1 g

GLU1161 Reduced XLFG xyloglucan oligosaccharide (DP10) XLFGol

100% xyloglucan oligosaccharides containing almost 75% of reduced XLFG or XLFGol.

C57H98O47 FW 1535.35

10 mg, 100 mg, 1 g

y

g



OOligoTech®®

GLU1162 Acetylated XLFG xyloglucan oligosaccharide (DP10) XLFG(Ac)

100% xyloglucan oligosaccharides containing almost 60% of mono-acetylated and non-reduced XLFG or XLFG(Ac).

C59H98O48 FW 1575.37

10 mg, 100 mg, 1 g

GLU1180 XLLFG xyloglucan oligosaccharide (DP13)

100% xyloglucan oligosaccharides containing almost 55% of non-reduced XLLFG.

C74H124O61 FW 1989.72

10 mg, 100 mg, 1 g

GLU1181 Reduced XLLFG xyloglucan oligosaccharide (DP13) XLLFGol

100% xyloglucan oligosaccharides containing almost 55% of reduced XLLFG or XLLFGol.

C74H126O61 FW 1991.74

10 mg, 100 mg, 1 g



OOligoTech®®

Other Xyloglucan oligosaccharides available upon request

GLU1182 Acetylated XLLFG xyloglucan oligosaccharide (DP13) XLLFG(Ac)

100% xyloglucan oligosaccharides containing almost 55% of non-reduced and mono-acetylated XLLFG or XLLFGol(Ac).

C76H126O62 FW 2031.76

10 mg, 100 mg, 1 g

Product Code Product Name Structure

GLU1100 XLG oligosaccharide

Degree of polymerization DP 6

C34H58O29 FW 930.80

GLU1101 Acetylated XLG oligosaccharide

Mono-acetylated form of XLG oligosaccharide

Degree of polymerization DP6

C36H60O30 FW 972.84

GLU1120 XXLG oligosaccharide


C45H76O38 FW 1225.05

GLU1121 Reduced XXLG oligosaccharide

(XXLGol)

Reduced form of XXLG with terminal glucitol


C45H78O38 FW 1227.07

GLU1122 Acetylated XXLG oligosaccharide

(XXLG(Ac))

Mono-acetylated form of XXLG oligosaccharide


C47H78O39 FW 1267.09

GLU1130 LFG oligosaccharide


C46H78O38 FW 1239.08



OOligoTech®®

Available prepacks 10 mg, 100 mg, 1 g on request

Product Code Product Name Structure

GLU1131 Reduced LFG oligosaccharide

Reduced form of LFG with terminal glucitol


C46H80O38 FW 1241.09

GLU1140 XLLG oligosaccharide


C51H86O43 FW 1387.19

GLU1141 Reduced XLLG

oligosaccharide (XLLGol)

Reduced form of XLLG with terminal glucitol


C51H88O43 FW 1389.21

GLU1142 Acetylated XLLG oligosaccharide

(XLLG(Ac)) Mono-acetylated form of XLLG


C53H88O44 FW 1429.23

GLU1150 XXFG oligosaccharide


C51H86O42 FW 1371.19

GLU1151 Reduced XXFG oligosaccharide

(XXFGol)

Reduced form of XXFG with terminal glucitol


C51H88O43 FW 1373.21

GLU1152 Acetylated XXFG oligosaccharide

(XLLG(Ac)) Mono-acetylated form of XXFG


C53H88O43 FW 1413.23

GLU1170 XLFGG oligosaccharide


C63H106O52 FW 1695.47

GLU1171 Reduced XLFGG oligosaccharide

(XXLGol)

Reduced form of XLFGG with terminal glucitol


C63H108O52 FW 1697.49



OOligoTech®®


Cellodextrin / Maltodextrin

ACTIVITIES AND USES

Cellodextrins are found a wide range of applications in functional food (probiotic benefits), pharmaceutical and chemical industries as well as agriculture and environmental engineering.

Maltodextrins are used as:

crispness enhancer for food processing, in food batters, coatings and glazes, (E number 1400),

textile finishing agent to increase weight and stiffness of textile fabrics, thickening and binding agent in pharmaceuticals and paper coatings.

Widely used as Analytical and Chromatographic tools enabling SEC calibration.


Cellodextrins are glucose polymers of two or more glucose monomers resulting from the breakdown of cellulose (from cotton linters as raw material). Cellodextrins consist of repeating β(1-4) linked D-glucose monomers. The most common cellodextrins are: cellobiose (DP=2) cellotriaose (DP=3) cellotetraose (DP=4) cellopentaose (DP=5) cellohexaose (DP=6)

The degree of polymerization (DP) indicates the number of linked glucose monomers it contains.

Maltodextrins are a group of low-molecular-weight sugar produced by the hydrolysis of starch. Maltodextrins are a linear α(1-4) linked D-glucose polymer. Industrial production is, in general, performed by acidic hydrolysis of potato starch.



OOligoTech®®


Cellodextrin

GLU300 Cellobiose

β(1-4) linked D-glucose Degree of polymerization (DP): 2.

C12H22O11 FW 342.29 [528-50-7]

10 mg, 100 mg

GLU301 Cellotriose


C18H32O16 FW 504.43

[33404-34-1]

10 mg, 100 mg

GLU302 Cellotetraose β(1-4) linked D-glucose

Degree of polymerization (DP): 4. C24H42O21

FW 666.57 [38819-01-1]

10 mg, 100 mg

GLU303 Cellopentaose


C30H52O26 FW 828.71 [2240-27-9]

10 mg, 100 mg

O

O

OHOH

OHOH

OHO OH

HOO

O

OHOH

OHOH

OHOHO

HOO

O

O

OHOH

OHOH

OHO OH

HOOOH

OHHO O

HO

O

O

OHOH

OHOH

OHO OHHO

HO

O

O

OHOH

OHOH

OHO OH

HOOOH

OHO O

HO

2



OOligoTech®®

GLU304 Cellohexaose


C36H62O31 FW 990.85 [2478-35-5]

10 mg, 100 mg

GLU305 Celloheptaose


C42H72O36 FW 1152.99 [52646-27-2]

5 mg, 10 mg, 100 mg

GLU306 Cellooctaose


C48H82O41 FW 1315.13

5 mg, 10 mg

GLU308 High DP Cello-Oligosaccharides

β(1-4) linked D-glucose oligomers Mixture containing 20% DP9 & 40% DP8 (HPAEC analysis)

5 mg, 10 mg

GLU309 Cello-Oligosaccharides Kit

Individually packaged Cello-oligosaccharide kit from

NEW Each proposed in first coming pack size

O

O

OHOH

OHOH

OHO OH

HOO

4

O

O

OHOH

OHOH

OHO OH

HOOOH

OHO O

HO

3

O

O

OHOH

OHOH

OHO OH

HOO

3


Cellobiose (DP2) to Celloheptaose (DP7).


OOligoTech®®


Maltodextrin

GLU310 Maltodextrin High DP oligosaccharide mixture α(1-4) linked D-glucose / α(1-6) branching

Observed Degree of polymerization (DP): 10 to 40. α(1-6) branching degree determined by 1H NMR

100 mg, 1 g, 10 g

GLU311 Maltodextrin oligosaccharide mixture α(1-4) linked D-glucose / traces of α(1-6) branching

Observed Degree of polymerization (DP): 2 to 15. α(1-6) branching degree determined by 1H NMR

100 mg, 1 g, 10 g

GLU312 Maltose α(1-4) linked D-glucose

Degree of polymerization (DP): 2.

C12H22O11 FW 342.29 [6363-53-7]

100 mg, 1 g, 10 g

GLU313 Maltotriose α(1-4) linked D-glucose


C18H32O16 FW 504.43 [1109-28-0]

100 mg, 1 g, 10 g

GLU314 Maltotetraose α(1-4) linked D-glucose


C24H42O21 FW 666.57

[34612-38-9]

100 mg, 1 g, 10 g

O

OH

OH

HOHO

O

OH

OH

HO

OH

O

O

OH

OH

HOHO

O

OH

OH

HO

O

O

O

OH

OH

HO

OH

O

OH

OH

HOHO

O

OH

OH

HO

O

O

O

OH

OH

HO

OHn=2



OOligoTech®®

GLU315 Maltopentaose α(1-4) linked D-glucose / traces of α(1-6) branching


C30H52O26 FW 828.71

[34620-76-3]

100 mg, 1 g

GLU316 Maltohexaose α(1-4) linked D-glucose / traces of α(1-6) branching


C36H62O31 FW 990.85

[34620-77-4]

100 mg, 1 g

GLU317 Maltoheptaose α(1-4) linked D-glucose / traces of α(1-6) branching


C42H72O36 FW 1152.99 [34620-78-5]

100 mg, 1 g

GLU318 Maltooctaose

α(1-4) linked D-glucose / traces of α(1-6) branching Degree of polymerization (DP): 8.

C48H82O41 FW 1315.13 [6156-84-9]

100 mg, 1 g

O

OH

OH

HOHO

O

OH

OH

HO

O

O

O

OH

OH

HO

OHn=3

O

OH

OH

HOHO

O

OH

OH

HO

O

O

O

OH

OH

HO

OHn=4

O

OH

OH

HOHO

O

OH

OH

HO

O

O

O

OH

OH

HO

OHn=5

O

OH

OH

HOHO

O

OH

OH

HO

O

O

O

OH

OH

HO

OHn=6



OOligoTech®®

GLU319 Maltononaose α(1-4) linked D-glucose / traces of α(1-6) branching


C54H92O46 FW 1477.27 [6471-60-9]

10 mg, 100 mg, 1 g

GLU320 Maltodecaose α(1-4) linked D-glucose / traces of α(1-6) branching


C60H102O51 FW 1639.41 [37331-89-8]

10 mg, 100 mg, 1 g

GLU322 Malto-Oligosaccharides Kit

Individually packaged Malto-oligosaccharide kit from Maltose (DP2) to Maltodecaose (DP10).

NEW Each proposed in first coming pack size

GLU330 Starch α(1-4) linked D-glucose / traces of α(1-6) branching

estimated by 1H NMR.

[9005-25-8]

On request

O

OH

OH

HOHO

O

OH

OH

HO

O

O

O

OH

OH

HO

OHn=7

O

OH

OH

HOHO

O

OH

OH

HO

O

O

O

OH

OH

HO

OHn=8

O

OHHO

O

O

OH

OH

HO

O

O

O

OH

OH

HO

OHn

O

OH

OH

HOHO

O



OOligoTech®®


Laminaran

EXAMPLES OF BIOMASS SOURCES

Laminaria digitata Ascophyllum nodosum


Laminaran (or laminarin) is a storage polysaccharide of Laminaria sp and other brown algae such as Fucus vesiculosus, Saccharina longicruris and Ascophyllum nodosum. It is a linear polysaccharide made up of β(1-3) glucan with some β(1-6) branch point.

The majority of laminarans contain polymeric chains of two types: one type is built only of Glcp residues (G-chains), whereas the other type is terminated with 1-O-substituted D-mannitol residues (M-chains).

ACTIVITIES AND USES

Laminaran is claimed to modulate immune responses in mammals. Sulfated laminaran has been shown to have heparin-like properties and to be an elicitor of plant defense reactions against viral infections. Laminaran also has dietary fiber properties.

Recommended paper(s) : Rioux et al. / Phytochemistry 70 (2009) 1069–1075).



OOligoTech®®


Laminaran

GLU500 Laminaran polysaccharide from Laminaria sp. β(1-3) linked D-glucose extracted and purified from

Laminaria sp. [9008-22-4]

100 mg, 1 g

GLU510 Laminaran polysaccharide from Fucus v. β(1-3) linked D-glucose extracted and purified from

Fucus vesiculosus [9008-22-4]

100 mg, 1 g

GLU501 Laminaran oligosaccharide mixture (<10 kDa cut-off) β(1-3) linked D-glucose oligosaccharides prepared and

purified from Laminaria sp. D-glucan polysaccharide by 10 kDa cut-off Ultrafiltration

10 mg, 100 mg

Please contact us for custom Laminari-oligosaccharide length tailored to your need

OH

O

OH

O

O

OH

OH

OHO

O

OH

OH

HOO

HO

n



OOligoTech®®


Lichenan / Isolichenan


Cetraria islandica Evernia prunastri


Lichenan (lichenin) is a linear polysaccharide isolated from lichen (ex Cetraria islandica, Evernia prunastri). It is a homologous (1-3) and (1-4) β-D-glucan. Lichenan structure is similar to that of barley and oat β-D-glucan; but the proportion of 1-4 to 1-3 linkage is higher (approximately 2:1).

Isolichenan (isolichenin), a cold-water-soluble linear (1-3) and (1-4) α-glucan, with different linkage groups among diverse taxa of lichens.

O

OH

OH

OHOO

O

OHOH

OHOH

O

HOHO OO

OH

OH

HO

O O

n

n

O

OH

OH

HOOH

O

OH

HO

O

OH

O

OH

HO

O

OH

OH

O

HO

O

O

ACTIVITIES AND USES

Recent data showed that lichenan exhibits potential anticancer and antiviral properties. Lichenan was also found to be a serious candidate for plant health product use (Stübler et al., 1996. Journal of Phytopathology, 144, no1;. 37-43).

Recommended paper : Freysdottir et al., 2008. Internat. Immunopharmacol., 8, 423–430.



OOligoTech®®


Lichenan / Isolichenan

GLU600 Lichenan polysaccharide (1-3) and (1-4) β-D-glucan

[1402-10-4]

1 g, 10 g

GLU601 Isolichenan polysaccharide (1-3) and (1-4) α–D-glucan

[53025-03-9]

100 mg, 1 g, 10 g

GLU602 Lichenan & Isolichenan polysaccharide Native grade (1-3) and (1-4) β-D-glucan, (1-3) and (1-4) α-D-glucan 1 g, 10 g

GLU610 Isolichenan oligosaccharides (Cut-off< 10kDa) Oligosaccharide mixture with average DP 30 to 50

hydrolyzed and purified from isolichenan polysaccharides by ultra-filtration

10 mg, 100 mg, 1 g

GLU611 Isolichenan oligosaccharides (Cut-off:3<->10 kDa) Oligosaccharide mixture with average DP 10 to 20

hydrolyzed and purified from isolichenan polysaccharides by successive ultra-filtration steps

10 mg, 100 mg, 1 g

O

OH

OH

OHOO

O

OHOH

OHOH

O

HOHO OO

OH

OH

HO

O O

n

n

O

OH

OH

HOOH

O

OH

HO

O

OH

O

OH

HO

O

OH

OH

O

HO

O

O



OOligoTech®®


Scleroglucan

GLU700 Scleroglucan polysaccharide β(1-3) linked D-glucose with side chain of β(1-6)

glucose every three unit.

[37339-90-5]

1 g, 10 g, 100 g

O

O

OH

OH

HOO

O

OH

OH

HOO

O

OH

O

OHO

O

HO

OH

OH

HO

n


Scleroglucan is a natural polysaccharide produced by fermentation of the filamentous fungus Sclerotium rolfsii. Its chemical structure consists of a linear β(1-3) D-glucose backbone with one β(1-6) D-glucose side chain every three main residue.


Sclerotium rolfsii

ACTIVITIES AND USES

Scleroglucan is intended for drug delivery system improvement (Coviello et al., 2005. Molecules, 10(1), 6-33). More precisely, scleroglucan is suitable for the preparation of sustained release tablets and ocular formulations. This peculiar Polysaccharide exhibits antiviral activities against Herpes Virus.

Scleroglucan also has applications in formulation for agriculture. In a view to replace Xanthan gum, Scleroglucan could be especially useful in food manufacturing where a heating process is involved, because of thermal stability that it exhibits (Survase et al.,2007. Fermentative Production of Scleroglucan, Food Technol. Biotechnol. 45 (2) 107–118).



OOligoTech®®


Lentinan

GLU800 Lentinan polysaccharide β(1-3) linked D-glucose with 2 side chains of single

β(1-6) D-glucose every five unit.

[37339-90-5]

10 mg, 100 mg, 1 g


Lentinan is a polysaccharide obtained from Lentinula edodes (Berk./ Pegler, 1976) which is an edible mushroom popular in East Asia known as Shiitake. This mushroom is one of the most popular edible mushrooms in the world, production globally being second only to the button mushroom Agaricus bisporus.

Lentinan is a beta glucan and its structure is reported as a β(1-3) linked D-glucose with β(1-6) branching point.


Shiitake (Lentinula edodes)

ACTIVITIES AND USES

Lentinan interest is increasing because of its high nutritional value and medicinal properties, traditionally acknowledged by oriental cultures, especially in China and Japan. Lentinan is attributed to have many functional properties such as antitumour and antiviral properties, as well as antimicrobial potential. Lentinula has shown neither evidence of being acutely toxic nor of having serious side effects.

Recommended paper: R. Hearst et al., 2009. Complementary Therapies in Clinical Practice, 15; 5–7.

O

O

OH

OH

HOO

O

OH

HOO

O

OH

HOO

HO

O

HO

OHHO

O

HO

O

HO

OHHO

O

O

OH

HOO

OH

O

OH

HOO

5

HO

O

HO

OHHO

O



OOligoTech®®


Pustulan

GLU900 Pustulan polysaccharide β(1-6) linked D-glucose polysaccharide

[37331-28-5]

100 mg, 1 g, 10 g

GLU910 Gentio-oligosaccharides mixture β(1-6) linked D-glucose oligomers prepared by

partial hydrolysis of pustulan. Mixture of gentiobiose, gentriose, gentiotetraose...

100 mg, 1 g, 10 g


Pustulan was first isolated from Lichen Lasallia pustulata and is a linear Glucan having β(1-6) linkage. Pustulan contains up to 2% of O-Acetyl groups (1 acetyl group every 10/12 glucose units). This polysaccharide is distributed in lichen group of Umbilicariaceae.


Lasallia pustulata

ACTIVITIES AND USES

Gentiooligosaccharides are useful as a taste improver for certain beverages. Gentiooligosaccharides (D.P. 2–3) have also been noted as prebiotic substances showing bifidogenetic activity. Such characteristics suggest the further potential of these gentiooligosaccharides in food and biology.

OOH

OHHO

HO O

O

HO

O

OHOH

O

HO

OHOH

OHn



OOligoTech®®

XXanthan Extraction from biomass



OOligoTech®®

XXanthan Extraction from biomass

GLU200 Xanthan gum polysaccharide

[98112-77-7]

1 g, 10 g

O

OH

O

OH

OHOH

O

OO

HO

OH3COOC

HOHO

O

OHOOC

OHHO

O

OHO

n

O

O

COO-

H3C

OHO


Xanthan gum is a bacterial polysaccharide produced by a process involving fermentation of glucose by the Xanthomonas campestris bacterium. Xanthan gum chain consists of repeating modules of five sugar units. The backbone of the polysaccharide chain consists of two β-D-glucose units linked through the 1 and 4 positions and the side chain consists of two mannose and one glucuronic acid. The side chain is linked to every other glucose of the backbone at the 3 position. About half of the terminal mannose units have a pyruvic acid group linked as a ketal to its 4 and 6 positions. The other mannose unit has an acetyl group at the 6 positions.


Xanthomonas campestris

ACTIVITIES AND USES

Xanthan gum is used as a food additive (thickener, stabilizer) and rheological modifier. It is accepted as a safe food additive in the USA, Canada and Europe, with E number E415. In cosmetics xanthan gum is used to prepare water gels usually in conjunction with bentonite clays. It is also used in oil-in-water emulsions to help stabilise the oil droplets against coalescence. It has some skin hydrating properties.



OOligoTech®®

CChitin / Chitosan Extraction from biomass



OOligoTech®®

CChitin // CChitosan Extraction from biomass


Chitin, the second most abundant natural biopolymer, is an unbranched chain of β(1-4) N-acetyl-D-glucosamine units. It is present in the cell walls of fungi and is the principal component of arthropod and lower animal exoskeletons (insect, crab, and shrimp shells…). Chitin is analogous in chemical structure to cellulose and it may be regarded as a derivative of cellulose, in which the hydroxyl groups of the second carbon of each glucose unit have been replaced with acetamido (-NH(C=O)-CH3) groups. The degree of acetylation (DA) is generally over 90%.

Chitosan is obtained by removing the acetyl groups (CH3-CO-) of the chitin. This process, called deacetylation, releases amine groups (NH) and gives the chitosan a cationic characteristic. The degree of acetylation is generally lower than 20%.


Agaricus bisporus Aspergillus niger Exoskeletons of Crustaceans

ACTIVITIES AND USES

Chitin and chitosan have been proven useful for several medical and industrial purposes (Kumar et al., 2000. Reactive and Functional Polymers, 46, 1-27). Many of the biological activities reported for Chitin/Chitosan are surrounding the fields of as antimicrobial, anticancer, antioxidant, and immunostimulant effects depending on their physico-chemical properties (Se-Kwon Kim et al., 2005. Carbohydrate Polymers 62, 357–368).

Recommended paper: Dai-Nghiep Ngo et al. 2009, Journal of Functional Foods, Vol. 1, Issue 2, pp 188-198.



OOligoTech®®

CChitin Extraction from biomass

GLU410 Chitin polysaccharide β(1-4) linked N-acetyl-D-glucosamine Polymer

DA>90%

[1398-61-4]

1 g, 10 g, 100g

GLU411 Colloidal Chitin polysaccharide β(1-4) linked N-acetyl-D-glucosamine Polymer

Suitable for enzyme assay (chitinases, …) [1398-61-4]

100 mg, 1 g, 10 g

GLU432 Chitin oligosaccharide DP2 Chitinbiose

β(1-4) linked N-acetylglucosamine; DP:2. Dimer prepared by hydrolysis of chitin; DA: 100%.

C16H28N2O11

FW 424.40 [35061-50-8]

NEW 10 mg, 100 mg, 1 g

GLU433 Chitin oligosaccharide DP3 Chitintriaose

β(1-4) linked N-acetylglucosamine; DP:3. Trimer prepared by hydrolysis of chitin; DA: 100%.

C24H41N3O16

FW 627.59 [38864-21-0]

NEW 10 mg, 100 mg, 1 g

GLU434 Chitin oligosaccharide DP4 Chitintetraose

β(1-4) linked N-acetylglucosamine; DP:4. Tetramer prepared by hydrolysis of chitin; DA: 100%.

C32H54N4O21

FW 830.78 [2706-65-2]

NEW 10 mg, 100 mg, 1 g

HO

OOH

AcNH

HOO

OOH

OHHO

AcNH

O

HO

OH

HO

O

NHAcO

NHAc

OH

HO O

HO

OH

O

NHAc

OH

O

HO

OH

HO

O

NHAcO

NHAc

OH

HO O

HO

OH

O

NHAc

OO

NHAc

OH

HO OH

O

HO

OH

O

O

NHAcO

NHAc

OH

HO

n



OOligoTech®®

CChitin Extraction from biomass

GLU435 Chitin oligosaccharide DP5 Chitinpentaose

β(1-4) linked N-acetylglucosamine; DP:5. Pentamer prepared by hydrolysis of chitin; DA: 100%.

C40H67N5O26

FW 1033.97 [36467-68-2]

NEW 10 mg, 100 mg, 1 g

GLU436 Chitin oligosaccharide DP6 Chitinhexaose

β(1-4) linked N-acetylglucosamine; DP:6. Hexamer prepared by hydrolysis of chitin; DA: 100%.

C48H80N6O31

FW 1237.16 [38854-46-5]

NEW 10 mg, 100 mg

GLU437 Chitin oligosaccharide DP7 Chitinheptaose

β(1-4) linked N-acetylglucosamine; DP:7. Heptamer prepared by hydrolysis of chitin; DA: 100%.

C56H93N7O36

FW 1440.35 [38854-46-5]

NEW 10 mg, 100 mg

GLU 40 Chitin-Oligosaccharides Kit

Individually packaged Chitin-oligosaccharide kit from Chitinbiose (DP2) to Chitinheptaose (DP7).

NEW Each proposed in 10 mg pack size

O

HO

OH

HO

O

NHAcO

NHAc

OH

HO O

HO

OH

O

NHAc

OH

3

O

HO

OH

HO

O

NHAcO

NHAc

OH

HO O

HO

OH

O

NHAc

OH

4

O

HO

OH

HO

O

NHAcO

NHAc

OH

HO O

HO

OH

O

NHAc

OH

5

Please contact us for custom oligosaccharide length and grade tailored to your need


4


OOligoTech®®

CChitoosan Extraction from biomass

GLU420 Chitosan polysaccharide

β(1-4) linked D-glucosamine polymer DA<10%; Viscosimetry 50 Cps

[9012-76-4]

1 g, 10 g, 100 g

GLU421 Chitosan oligosaccharides mixture β(1-4) linked D-glucosamine; average range DP:2 to 25.

Oligomer mixture prepared by hydrolysis of chitosan polymer.

DA<20%.

100 mg, 1 g, 10 g

GLU422 Chitosan oligosaccharides DP60 β(1-4) linked D-glucosamine; average DP:60

Oligomers prepared by hydrolysis of chitosan; DA<20%. 10 mg, 100 mg




Oligomers prepared by hydrolysis of chitosan; DA<20%.

10 mg, 100 mg





O

HO

OH

O

O

NH2O

NH2

OH

HO

n



OOligoTech®®

UUlvan Extraction from biomass



OOligoTech®®



Ulvans are structural acid polysaccharides present in cell wall of green algae (Ulva and Enteromorpha). They are highly sulphated and essentially composed with rhamnose 3-sulfate, xylose, xylose 2-sulfate, glucuronic acid and iduronic acide units. The four recurrent units are: Ulvanobiuric 3-sulfate type A acid Ulvanobiuric 3-sulfate type B acid Ulvanobiose 3-sulfate acid Ulvanobiose 2’, 3 disulfate acid

Ulvanobiuric 3-sulfate type A acid Ulvanobiuric 3-sulfate type B acid β(1-4) D-GlcA- α(1-4) L-Rha 3 sulfate β(1-4) L-IdoA- α(1-4)-L-Rha 3 sulfate

Ulvanobiose 3-sulfate acid Ulvanobiose 2’, 3 disulfate acid

β(1-4)-D-Xyl- α(1-4)-L-Rha 3 sulfate β(1-4) D-Xyl 2-sulfate- α(1-4)-L-Rha 3 sulfate


Ulva sp. Enteromorpha sp.

ACTIVITIES AND USES

Ulvan presents several potentially valuable biological properties for agricultural, food and pharmaceutical applicationsamong which Anticoagulant activities (heparin like), Antioxydant activities, Antihyperlipidemic activities, Antitumoral activities.

Recommended paper: Lahaye and Robic, 2007. Biomacromolecules, vol. 8, N°6.



OOligoTech®®


ULV100 Ulvan polysaccharides from Ulva sp. Native grade Polysaccharides extracted and purified from the green seaweed Ulva

armoricana. Molecular weight generally observed from 90 to 500 kDa. (SEC & 1H NMR characterization).

1 g, 10 g, 100 g

ULV102 Ulvan polysaccharides from Ulva sp. Fine Grade Polysaccharide extracted from the green seaweed Ulva armoricana and purified

by Anion Affinity. Low Glucan content Molecular weight generally observed over 300 kDa. (SEC & 1H NMR characterization). Low Glucan content.

100 mg, 1 g, 10 g

ULV101 Ulvan polysaccharides from Enteromorpha sp. Native grade Polysaccharides extracted and purified from the green seaweed Enteromorpha

intestinalis. Molecular weight generally observed around 400 kDa. (SEC & 1H NMR characterization).

1 g, 10 g, 100 g

ULV103 Ulvan polysaccharides from Enteromorpha sp. Fine grade Polysaccharide extracted from the green seaweed Enteromorpha intestinalis

and purified by Anion Affinity. Low Glucan content. Molecular weight generally observed over 300 kDa. (SEC & 1H NMR characterization). Low Glucan content.

100 mg, 1 g, 10 g

ULV010 Ulvan oligosaccharides (cut-off<10kDa) from Ulva sp.

Oligosaccharides obtained from Ulva armoricana polysaccharide hydrolysis.

Purified by 10kDa cut-off ultrafiltration.

10 mg, 100 mg, 1 g



OOligoTech®®


ULV011 Ulvan oligosaccharides (cut-off<10kDa) from Enteromorpha sp. Oligosaccharides obtained from Enteromorpha intestinalis polysaccharide

hydrolysis. Purified by 10kDa cut-off ultrafiltration.

10 mg, 100 mg, 1 g

ULV001 Ulvan oligosaccharides (cut-off: 3<->5kDa) from Ulva sp. Oligosaccharides obtained from Ulva armoricana polysaccharide hydrolysis.

Purified by 3kDa and 5kDa cut-off ultrafiltration steps.

10 mg, 100 mg, 1 g

ULV002 Ulvan oligosaccharides (cut-off: 1<->3kDa ) from Ulva sp Oligosaccharides obtained from Ulva armoricana polysaccharide hydrolysis.

Purified by 1kDa and 3kDa cut-off ultrafiltration steps.

10 mg, 100 mg, 1 g

ULV003 Ulvan oligosaccharides (cut-off: 650 Da<->1kDa) from Ulva sp. Oligosaccharides obtained from Ulva armoricana polysaccharide hydrolysis.

Purified by 650Da and 1kDa cut-off ultrafiltration steps. 10 mg, 100 mg, 1 g

ULV005 Ulvan oligosaccharides (cut-off: 3<->5kDa) from Enteromorpha sp.

Oligosaccharides obtained from Enteromorpha intestinalis polysaccharide hydrolysis. Purified by 3kDa and 5kDa cut-off ultrafiltration steps.

10 mg, 100 mg, 1 g

ULV006 Ulvan oligosaccharides (cut-off: 1<->3kDa ) from Enteromorpha sp. Oligosaccharides obtained from Enteromorpha intestinalis polysaccharide

hydrolysis. Purified by 1kDa and 3kDa cut-off ultrafiltration steps.

10 mg, 100 mg, 1 g

ULV007 Ulvan oligosaccharides (cut-off: 650 Da<->1kDa) from Enteromorpha sp

Oligosaccharides obtained from Enteromorpha intestinalis polysaccharide hydrolysis. Purified by 650Da and 1kDa cut-off ultrafiltration steps.

10 mg, 100 mg, 1 g

Please contact us for custom ulvan oligosaccharide length tailored to your need



OOligoTech®®

FFucooiiddann / Galactofucan Extraction from biomass



OOligoTech®®

FFucooiiddaan / Galactofucan Extraction from biomass


Fucoidans are sulfated fucan polysaccharides occurring in brown marine seaweeds cell wall (Phaeophyceae, mainly Fucales and Laminariales), in sea urchin egg gelatinous coat, and in sea cucumber cuticule. Numerous variations of the basic structure are found in different species of Phaeophycea. The structure of fucan polysaccharide consists of α(1-3) linked sulphated L-fucose backbone in some order (eg Laminariales) with alternating α(1-3) and α(1-4) linked residues in other orders (eg Fucales). Other units (like galactose) and substitutions (acetate) also occur.

Galactofucan is a sulphated (10-30%) backbone dominated by both 3-linked α-fucopyranose and β-galactopyranose moieties. Galactofucan can be extracted from the brown seaweed Undaria pinnatifida and Saccharina longicruris.

Versatility of fucoidan structures

OOSO3

-

OOSO3

-

OOH

-O3SO

OOH

O

-O3SO

OOSO3

-

O

OH

OOSO3

-

O

OHOH

OOSO3

-

OOSO3

-

OOH

OH

OOH

O

OH

OOSO3

-

O

OH

OOSO3

-

O

-O3SOOH

O

OOSO3

-

OOH

OH

OOH

O

-O3SO

OOH

O

OOH

O

OHOH

OHO

OHOH

O

OOH

OHOH

O

OOSO3

-

OHO

OOSO3

-

HO

OOSO3

-

OOH

OOSO3

-

OHO

OOSO3

-

OHHO

O

POSSIBLE BIOMASS SOURCES

Fucus vesiculosus Undaria pinnatifida Ascophyllum n. Durvillea antarctica

ACTIVITIES AND USES

Fucoidan and galactofucan exhibit numerous potential therapeutic activities. Noteworthy, they have been shown to have anti-inflammatory, anticoagulant/heparin-like activities, antiviral and antiparasitic activities. They can act has antiangiogenic and antitumoral agents.

Recommended papers: Synytsya et al., 2010. Carbohydrate Polymers, vol.81, pp 41-48. Rioux et al., 2010. Phytochem., vol.71.



OOligoTech®®

FFucooiddan / Galactofucan Extraction from biomass

FUC100 Fucoidan polysaccharide from Fucus vesiculosus Highly sulphated L-fucose polymer extracted and

purified from the brown seaweed Fucus vesiculosus. Non-reduced extremity. 1H NMR characterization

[9072-19-9]

100 mg, 1 g, 10 g

FUC300 Fucoidan polysaccharide from Chorda filum Highly sulphated L-fucose polymer extracted and

purified from the brown seaweed Chorda filum. Non-reduced extremity.1H NMR characterization

[9072-19-9]

100 mg, 1 g, 10 g

FUC400 Fucoidan polysaccharide from Ascophyllum nodosum Highly sulphated L-fucose polymer extracted and

purified from the brown seaweed Ascophyllum nodosum. Non-reduced extremity. 1H NMR characterization

[9072-19-9]

100 mg, 1 g, 10 g

FUC500 Fucoidan polysaccharide from Durvillea antarctica Highly sulphated L-fucose polymer extracted and

purified from the brown seaweed Durvillea antarctica. Non-reduced extremity.1H NMR characterization

[9072-19-9]

100 mg, 1 g, 10 g

FUC200 Galactofucan polysaccharide from Undaria pinnatifida Sulfated polymer of L-fucose and D-galactose

extracted and purified from the brown seaweed Undaria pinnatifida. Non-reduced extremity.1H NMR characterization

[9061-39-6]

100 mg, 1 g

FUC600 Fucoidan polysaccharide Kit Individually packaged Highly sulphated L-fucose

polymer extracted and purified from 4 species of brown seaweed.




OOligoTech®®

FFucooidan / Galactofucan Extraction from biomass

FUC110 Fucoidan oligosaccharides (Cut-off<10kDa) from Fucus vesiculosus Highly sulphated L-fucose oligomer obtained from the brown seaweed Fucus

vesiculosus polysaccharide hydrolysis. Purified by 10kDa cut-off ultrafiltration.

10 mg, 100 mg, 1 g

FUC310 Fucoidan oligosaccharides (Cut-off<10kDa) from Chorda filum Highly sulphated L-fucose oligomer obtained from the brown seaweed Chorda

filum polysaccharide hydrolysis. Purified by 10kDa cut-off ultrafiltration.

10 mg, 100 mg, 1 g

FUC410 Fucoidan oligosaccharides (Cut-off<10kDa) from Ascophyllum n. Highly sulphated L-fucose oligomer obtained from the brown seaweed

Ascophyllum nodosum polysaccharide hydrolysis. Purified by 10kDa cut-off ultrafiltration.

10 mg, 100 mg, 1 g

FUC510 Fucoidan oligosaccharides (Cut-off<10kDa) from Durvillea a. Highly sulphated L-fucose oligomer obtained from the brown seaweed

Durvillea Antarctica polysaccharide hydrolysis. Purified by 10kDa cut-off ultrafiltration.

10 mg, 100 mg, 1 g

FUC210 Galactofucan oligosaccharides (Cut-off<10kDa) from Undaria pinnatifida

Highly sulphated Galactofucan oligomer obtained from the brown seaweed Undaria pinnatifida polysaccharide hydrolysis. Purified by 10kDa cut-off ultrafiltration.

10 mg, 100 mg




OOligoTech®®

XXylan Extraction from biomass



OOligoTech®®



Xylan is a wide family of highly complex polysaccharides that are found in plant cell walls (Hardwood such as birch, larch woods) and some algae. Xylan, the most abundant of the hemicelluloses in plant cell walls, has a linear backbone structure consisting of β-D-(1-4) linked xylosyl residues that, depending on its origin, may contain branches of L-arabinofuranosyl, acetyl, D-glucuronosyl and 4-O-methylglucuronosyl residues.

Xylans are cell wall constituants:

Of some green algae (mainly macrophytic siphonous genera, like Codium, Caulerpa or Bryopsis Genus). The linear backbone structure is then based on β-D-(1-3)-xylose chain. Of some red algae (Nemaliales and Palmariales). According to their origins, they may be

made of β(1-3) and/or β(1-4)-D-xylose residues and may contain galactopyranosyl, uronic acids, sulfate and phosphate residues.


Palmaria palmata

ACTIVITIES AND USES

Xylan represents an interesting source of raw material for the preparation of modified polysaccharides with novel biological activities. In particular, anticoagulant, antithrombotic and antiviral activities has been shown for sulphated or phosphorylated xylan polysaccharides (P. Mandal, et al., Int. J. Biol. Macromol.2010).

Recommended paper: E. Deniaud et al. International Journal of Biological Macromolecules ; 33 (2003) 9–18.



OOligoTech®®


XYL100 Xylan polysaccharide from Palmaria palmata Xylan polysaccharide is extracted and purified from the red seaweed Palmaria

palmata. β(1-3) and β(1-4) D-xylose linked polymer. β(1-3)/β(1-4) ratio 1:4 Xylose, ≥98% HPAEC

1 g, 10 g, 100 g

XYL101 Glucurono-Arabinoxylan polysaccharide from wheat bran Glucurono-Arabinoxylan polysaccharide is extracted and purified from wheat

bran β(1-4)-D-xylose linked polymer branched with arabinose and glucuronic acid.

100 mg, 1 g, 10 g

XYL110 Xylan oligosaccharides XOs (Cut-off<10kDa) from Palmaria p. Xylan oligosaccharides (XOs) are obtained from Palmaria palmata

polysaccharide hydrolysis. Purified by 10kDa cut-off ultrafiltration.

Degree of polymerization (DP): generally observed from 2 to 25.

10 mg, 100 mg, 1 g

XYL111 Xylan oligosaccharides XOs (cut-off: 650Da<->3kDa) from Palmaria p. Xylan oligosaccharides (XOs) are obtained from Palmaria palmata polysaccharide

hydrolysis.

Purified by 3kDa and 650 Da cut-off ultrafiltration steps.

10 mg, 100 mg, 1 g

Please contact us for custom Xylo-oligosaccharide length tailored to your need

OH

O

O

O

OH

OO

O

OH

HOO

HOO

OH

HO O

n

HO



OOligoTech®®

GGalactan Extraction from biomass

Arabinogalactan Carrageenan

Agar



OOligoTech®®


Arabinogalactan


Green seaweeds Codium fragile and Codium vermilara biosynthesize water-soluble sulfated arabinogalactans (AG) and minor α(1-4) D-glucans and β(1-4) D-mannans. Arabinogalactan polysaccharides are composed of 3-linked β-D-galactopyranose and β-L-arabinopyranose residues; they are highly sulfated and potentially substituted with pyruvic acid ketals.

Moreover, it has been found that polysaccharide components cellulose, galactomannan and arabinogalactan-proteins (AGPs) represent about 50% of dry weight of coffee beans, from which AGPs constitute about 15%.


Codium fragile Coffee beans

ACTIVITIES AND USES

Arabinogalactan (AG) has a wide spectrum of possible uses. It can be employed, for example, as an adhesion-promoting agent in cardboard production, binding agent for gouache and watercolor, thickener in textile industry. AG has also been proposed for use in pharmaceutical industry as a binder in pill production, emulsifying agent for stabilizing oil emulsions (E number E409).

Arabinogalactans become important due to their prebiotic, cholesterol-lowering, emulsifying, immunomodulatory, and other properties which make from these glycoconjugates commercially important article for food and pharmaceutical industries (Capek et al., 2009. Carbohydrate Polymers).

Recommended paper:

M. Ciancia et al.; International Journal of Biological Macromolecules. 41, (2007), 641–649.



OOligoTech®®


Arabinogalactan

GAL100 Sulfated Arabinogalactan polysaccharide (from Codium f.) Native grade Arabinogalactan polysaccharide is extracted and purified from the green

seaweed Codium fragile. The sulphated polysaccharide is composed of 3-linked β-D-galactopyranose (C4 or C6 sulfated) and β-L-arabinopyranose (C2 or C3 sulfated) residues.

Polysaccharide extremity is non-reduced. 1 g, 10 g

GAL101 Sulfated Arabinogalactan polysaccharide (from Codium f.) Fine grade Arabinogalactan polysaccharide is extracted from the green seaweed Codium

fragile and purified by Anion Affinity. Low Mannan & Glucan content.

Polysaccharide extremity is non-reduced.

100 mg, 1g

GAL110 Sulfated Arabinogalactan oligosaccharides (Cut-off<10kDa)

Sulfated Arabinogalactan oligosaccharide obtained from the hydrolysis of green seaweed Codium fragile polysaccharide.

Purified by 10kDa cut-off ultrafiltration

10 mg, 100 mg

GAL111 Sulfated Arabinogalactan oligosaccharides (Cut-off: 3kDa<->10kDa)


Purified by successive 10kDa and 3 kDa cut-off ultrafiltration

10 mg, 100 mg

GAL112 Sulfated Arabinogalactan oligosaccharides (Cut-off<3kDa)


Purified by 3 kDa cut-off ultrafiltration

10 mg, 100 mg



OOligoTech®®


Carrageenan


Carrageenan is a generic term for several polysaccharides also extracted from red seaweeds (Rhodophyceae). Carrageenan compounds differ from agar in that they have sulfate groups (-OSO3

-) in place of some hydroxyl groups. Carrageenans are water-soluble galactans extracted from some red seaweeds (mainly Chondrus, Euchema and Gigartina Genuses). They have a repeating backbone of 3-linked β-D-galactose (G-units) and 4-linked α-D-galactose (D-units), containing a varying degree of sulphate (from 20 to 50% sulfation degree). 4-linked α-D-galactose residues may also be found as 3’ and 6’ anhydro residues (DA-units).

The commercially important κ-carrageenan contains a 3,6-anhydro-D-galactopyranose (AnGalp) in place of α-D-galactopyranose, giving it gelling properties. The addition of a 2-O-sulfo group to the κ-carrageenan affords another commercially important carrageenan, -carrageenan.

Carrageenan classification is based on number, position of sulfo groups and presence of 3,6-anhydro-D-galactopyranose (AnGalp) in place of α-D-galactopyranose (Nomenclature given in Knutsen et al.1994. Botanica marina, 37, 163-169).


Chondrus crispus Agardhiella tenera

ACTIVITIES AND USES

In the food industry field, carageenan are thickening suspending, gelling and stabilizing agents (Food additive with E number 407). Antiviral (HSV, HIV), Antitumor activities. Cosmetics (anti-oxydant activity, antihyperlipidemic). Carrageenans have shown plant health activities.

κ-carrageenans have shown immunomodulation and antitumor activities (H. Yuan et al. 2006/ Cancer Letters 243; 228–234).

Recommended paper: V.L. Campo et al. / Carbohydrate Polymers 77 (2009) 167–180



OOligoTech®®


Carrageenan

GAL200 Kappa-Carrageenan polysaccharides Kappa (κ) group containing polysaccharides which

residues are C4-sulfated β-D-galactopyranosyl. B unit contains 3,6 anhydo bridge.

[1114-20-8]

On request

GAL300 Lambda-Carrageenan polysaccharides Lambda ( ) Group containing polysaccharides which

residues are C2 sulfated β-D-galactopyranosyl. [9064-57-7]

On request

GAL400 Iota-Carrageenan polysaccharides Iota ( ) Group containing polysaccharides which residues

are C4 sulfated -D-galactopyranosyl. G4S-DA2S [9062-07-1]

On request

O

OH

OSO3- OH

O

-O3SO

O

O

O

O

O

OH

OSO3- OH

O

OH

O

O

O

O

O

OSO3-

OSO3- OH

O

-O3SO

OH

O O

OH

O



OOligoTech®®


Agar

GAL500 Agar polysaccharides Polysaccharide extracted from red seaweed Gracilaria

composed of β-D-Galactose and 3,6 anhydro-L-galactose disaccharide repeating units

[9002-18-0]

On request


Agar is extracted from red seaweed (mainly from Gelidium and Gracilaria genera) and is used in many foods as a gelling agent. Agar is a polymer of agarobiose, a disaccharide composed of D-galactose and 3,6-anhydro-L-galactose.


Gracilaria sp.

ACTIVITIES AND USES

Highly refined agarose is an industrially important high value material and is extensively used in biotechnology and molecular biology applications (used as a medium for culturing bacteria, cellular tissues, and for DNA fingerprinting).

In the food industry field, Agarose is widely used as stabilizer, gelling agent and thickener (E number E406). Laxative properties and stabilizer of pharmaceutical products.

O

O

OH

OHOH

OH

O

O

CH2

O



OOligoTech®®

MMannan Extraction from biomass

Mannan Xylomannan

Galactomannan Glucomannan

Galactoglucomannan



OOligoTech®®


Mannan


Mannan that consists of β(1-4)-mannosyl residues is abundant in nature, and is obtained as a pure homopolymer from the endosperm of the monocotyledonous (e.g. Arecaceae family), such as ivory nuts (Phytelephas sp.), dates (Phoenix dactylifera), as well as from the cell walls of several green algae belonging to the Codiaceae and Dasycladaceae families. It is also distributed within some species from Apiaceae, Rubiaceae (Coffea sp.) and Asteraceae.

Mannan is found to be a major constituent of Mycobacteriae and yeast cell wall representing principal surface antigen, with species-specific structure and composition. Saccharomyces cerevisiae mannan differs, for example from that of C. albicans by side chain structure as well as substitution frequency.

Mannan is often compared to another abundant natural polymer, cellulose, because of the similarities in their chemical structures.


Coffee beans Ivory nuts

ACTIVITIES AND USES

Mannans are known as important biological response modifiers, which can exhibit a remarkable range of immunopharmacological and therapeutic activities. Aloe species contain O-acetyl-β-D-(1-4) mannan, which have been reported to show antiviral and antiproliferative properties in vivo. Mannan from Aloe saponaria inhibits the proliferative response in normal and tumoral cells (C.L.O. Petkowicz et al., 2007. Carbohydrate Polymers, 69, 659–664).

Recommended paper: R. Hori et al., 2007. Carbohydrate Polymers, 70, 298–303.



OOligoTech®®


Mannan

MAN800 Mannan polysaccharide (Ivory Nut or Tagua) β(1-4) linked D-mannopyranosyl residues extracted

and purified from Ivory Nut (Tagua).

Mannose content >90%

[37251-487-1]

1 g, 10 g, 100 g

MAN801 Acemannan polysaccharide (Aloe vera) β(1-4) linked D-mannopyranosyl residues partially O-acetylated extracted

and purified from Aloe vera.

10 mg, 100 mg

MAN810 Mannan oligosaccharides (cut-off<10kDa) β(1-4) linked D-mannose oligosaccharides prepared by mannan or

galactomannan polysaccharide hydrolysis. Purified by 10 kDa cut-off ultrafiltration.

Degree of polymerization (DP): generally observed from 2 to 24

n=1 to 12 10 mg, 100 mg, 1 g

O

HO

HOOH

OO O

HO

HOOH

O

n

O

HO

HOOH

OO O

HO

HOOH

O

n

Please contact us for custom Manno-oligosaccharide length tailored to your need



OOligoTech®®


Xylomannan

MAN100 Sulfated Xylomannan polysaccharides Sulfated α(1-3) linked Mannose Polymers + Branched β(1-2)-Xylose

Mannopyranosyl residues: C2 and C4 sulfated.

On request

OHO

O

HO

HO

O

O

HOOSO3

-

O

HO

OOSO3

-OH

O

HO

O

OH

O

HO


The red seaweed Nothogenia fastigiata synthesizes a complex system of polysaccharides comprising neutral xylans of the β-D-(1-3), β-D-(1-4)-mixed linkage type, sulfated xylo-galactans of the agaroid type and a family of sulfated xylomannans. These polysaccharides are α(1-3)-linked O-mannans with position 2- and 6-sulfated. The main mannose backbone has β-D-(1-2)-linked O-xylose side chains.


Nothogenia fastigiata

ACTIVITIES AND USES

Antiviral activity, Herpes simplex virus type 1 and 2 in vitro activity: inhibits replication of Herpes simplex (HVS) 1 and 2, human cyclomegalovirus (HCLV), respiratory syncytial virus (RSV), Influenza A & B, Junin virus, Tacaribe, Simian virus (P. Mandal et al., 2008. Phytochem., vol. 69, 2193–2199).

Xylomannan is a newly discovered antifreeze molecule, found in the freeze-tolerant Alaskan beetle Upis ceramboides (Walters KR Jr et al., 2009. PNAS; 106 (48):20210-5).



OOligoTech®®


Galactomannan


Among storage polysaccharides of higher plants, galactomannans constitute the second most abundant group. They are found especially in legume seeds, and have different degrees of side-chain substitution, molecular masses, and fine structures. Their structure consists of a main chain of (1-4)-linked β-D-mannopyranosyl units substituted by α-D-galactopyranosyl units and are distinguished by the content of D-mannopyranosyl units which ranges from 60 to 80%. Galactomannans can also be found in Fungus species such as Aspergillus. Their related structure consists of a linear α-linked mannan core with side chains of an average of five β(1-5) linked galactofuranosyl residues.


Galactomannan mainly found in leguminous seeds:

Fenugreek Gum, mannose:galactose Ratio~1:1 Guar Gum, mannose:galactose Ratio~2:1 – E412 Tara Gum, mannose:galactose Ratio~3:1 – E417 Carob Gum, mannose:galactose Ratio ~4:1 – E410

Fenugreek Carob Guar

ACTIVITIES AND USES

Galactomannans are polysaccharides widely used as emulsion stabilizers in the pharmaceutical and food industries (monitoring the viscosity of the water phase) which are mainly obtained from endosperm of leguminous seeds. Given their low toxicity, they are also used in the cosmetic and biomedical industries, either alone or conjugated to antimumoral drugs. Guar and Locust Bean Gum (LBG) are commonly used in ice cream to improve texture and reduce ice cream meltdown. Tara is seeing growing acceptability as a food ingredient but is still used to a much lesser extent than guar or LBG. Guar has the highest usage in foods. Lubricants to improve eye comfort. This polysacc arides from Caesalpinia spinosa also revealed immunoregulatory activities in human DCs and could be possibly used as antitumoral adjuvant.

Recommended paper : S.P. Santander et al International Immunopharmacology 11 (2011) 652–660.


h

.,


OOligoTech®®


Galactomannan

MAN200 Galactomannan polysaccharides from Guar β(1-4) linked D-mannopyranosyl units substituted by

α(1-6)-D-galactopyranosyl units. Ratio~2:1. Viscosimetry (1%, H2O):2400-3400 cps

[9000-30-0]

1 g, 10 g

MAN201 Galactomannan polysaccharides from Carob (locust bean gum) β(1-4) linked D-mannopyranosyl units substituted by

α(1-6)-D-galactopyranosyl units. Ratio~4:1. Viscosimetry (1%, H2O):2500-3000 cps

[9000-40-2]

1 g, 10 g

MAN202 Galactomannan polysaccharides from Fenugreek β(1-4) linked D-mannopyranosyl units substituted by

α(1-6)-D-galactopyranosyl units. Ratio~1:1. [9000-40-2]

100mg, 1 g, 10 g

MAN213 Galactomannan oligosaccharides DP3 from Carob Mixture of β(1-4) linked D-mannose oligosaccharides

Prepared by controlled hydrolysis from carob

Average DP: 3. Average observed Man/Gal Ratio~ 4-7.

10 mg, 100 mg, 1 g




10 mg, 100 mg, 1 g




10 mg, 100 mg, 1 g



OOligoTech®®


Galactomannan

MAN300 α-Digalactosyl mannopentaose Manβ1-4(Galα1-6)Manβ1-4(Galα1-6)Manβ1-4Manβ1-4Man

10 mg, 100 mg

MAN400 α-galactosyl Mannobiose & Mannotriose Manβ1-4(Galα1-6)Man + Manβ1-4Manβ1-4Man

10 mg, 100 mg

MAN500 α-galactosyl Mannotriose Manβ1-4Manβ1-4(Galα1-6)Man

10 mg, 100 mg

O

HO

HO

O

OOO

HO

OH

O

O

HO

OH

OH

O

OH

O

HO

HOOH

HO

O

HO

OH

OHOH

O

HO

OH

O

OH

O

HO

HOOH

OH

O

HO

HOOH

OOO

HO

OH

OH

O

HO

OH

OH

O

OH

O

HO

HOOH

HO

O

HO

HOOH

OHO O

HO

OH

OH

O

HO

OH

OH

O

OH

O

HO

HOOH

OHO O

HO

OH

O

OH

O

HO

HOOH

OH



OOligoTech®®


Glucomannan


Glucomannan is a dietary fiber obtained from tubers of Amorphophallus konjac cultivated in Asia. Flour from the konjac tubers is used to make Japanese shirataki noodles which are very low in calories. The polysaccharide consists of glucose (G) and mannose (M) in a proportion of 5:8 joined by β(1-4) linkages. The basic polymeric repeating unit has the pattern: GGMMGMMMMMGGM. Short side chains of 11-16 monosaccharides occur at intervals of 50-60 units of the main chain attached by β(1-3) linkages. Also, acetate groups on carbon 6 occur at every 9-19 units of the main chain. Hydrolysis of the acetate groups favors the formation of intermolecular hydrogen bonds that are responsible for the gelling action.


Glucomannan comprises 40% by dry weight of the roots or corm of the konjac plant. It is also a hemicellulose that is present in large amounts in the wood of conifers and in smaller amounts in the wood of dicotyledons.

Konjac Conifers

ACTIVITIES AND USES

As a food additive, glucomannan is used as an emulsifier and thickener. It has E number E425(ii). Glucomannan is used as a hunger suppressant because it produces a feeling of fullness by creating very viscous solutions that retard absorption of the nutrients in food. One gram of this soluble polysaccharide can absorb up to 200 ml of water, so it is also used for absorbent articles such as disposable diapers and sanitary napkins. Glucomannan also makes up the majority of shirataki noodles.

Glucomannans show health benefits for: constipation, cholesterol, diabetes, obesity (An et al., 2010. Carbohydrate Polymers).



OOligoTech®®


Glucomannan

MAN600 Glucomannan polysaccharide from Konjac Portion (GGMM) of the glucomannan repeating unit randomly

distributed. The second glucose has an acetate group.

DA (acetylation %) generally observed <15%. M/G ratio ~ 1.5 DA and Mannose/glucose ratio performed by HPAEC and 1H NMR

[37220-17-0]

1 g, 10 g

MAN610 Glucomannan oligosaccharides (Cut-off<10kDa) Oligomers obtained from glucomannan polysaccharide hydrolysis and purified by

10kDa cut-off ultrafiltration.

DA and Mannose/glucose ratio performed by HPAEC and 1H NMR

n 10 mg, 100 mg, 1 g

O

HO

OHOH

O

OH

OO

O

O

OAcOH

OHOH

O

HO

HOHOO

OH

O

O

HO

OHOH

O

OH

OO

O

O

OAcOH

OHOH

O

HO

HOHOO

OH

O



OOligoTech®®


Galactoglucomannan

MAN700 Galactoglucomannan polysaccharide

On request

O...O

R

R

O

OH

O

R

R

O

OH

O

HOO

OH

OH

O

R

R

O

OH

O

HO

OH

O

O

OH

HO

OH

OH

O...

n n

R= -OAC or OH


Galactoglucomannans are polysaccharides consisting of a mannose backbone with side groups. Main chain is composed of β(1-4) linked D-mannopyranosyl units interspersed with a lower number of β(1-4) linked D-glucopyranosyl units. Single (1-6)-linked α-galactopyranosyl units are found as side groups branched to the mannopyranosyl units. In softwood, the GGMs are O-acetylated at C-2 and C-3 of the mannosyl units. Their structures are numerous due to their ability to be acetylated and due to their wide distribution among higher plants (hemicellulose). They are soluble in alkali.


Galactoglucomannans (i.e GGMs) are a large group of polysaccharides which are prominent components of coniferous woods (almost 20% of dry matter from softwoods are hemicellulosic galactoglucomannan). GGMs are also found in other wood species as well as in the primary cell walls of other plants, fruits, and seeds, such as flax, tobacco plants, or kiwifruit.

Spruce (Picea abies)

ACTIVITIES AND USES

Plant Health Product acting on growth development (Kollarova et al. 2009 Plant Science 177 324–330). Additives with immuno-potentiating and antioxidant properties in food products and pharmaceutical formulations.


.


OOligoTech®®

AAlginate Extraction from biomass



OOligoTech®®

AAlgiinate Extraction from biomass


Alginic acid (algin, alginate) is a polysaccharide that is abundant in the cell walls of brown algae. (Pheophyceae, mainly laminariales and fucales) and in specific bacteria (acetylated form). Chemically, it is a linear copolymer with homopolymeric blocks of (1-4)-linked β-D-mannuronate (M) and its C-5 epimer α-L-guluronate (G) residues, respectively, covalently linked together in different sequences or blocks.

The monomers can appear in homopolymeric blocks of consecutive G-residues (G-blocks), consecutive M-residues (M-blocks), alternating M and G-residues (MG-blocks) or randomly organized blocks.

Chemical Structures of Alginate

O

OH

HO

HOOC

OO

HOOC OH

OO

OOH

O

HO

HO

HOOC

O

HOOC OH

HOHO

M M M M

OOH

OH

O

OOH

OOH

O

OOH

OHO

O

OH-OOC

-OOC

-OOC

-OOC

OH

OH

G

G

G

GO

OH

HO

HOOC

OO

OOH

-OOC

OH

G

O

OOH

HO

HOOC

HO

M

M


Fucus vesiculosus Laminaria japonica

ACTIVITIES AND USES

Alginates are widely used as waterproofing and fireproofing fabrics, as a gelling agent, for thickening drinks, ice cream and cosmetics, as a detoxifier that can absorb poisonous metals from the blood, as food additives (E number from E400 to E405), healthcare products (rheological properties)… Alginates also show health benefits as dermal fibroblast Modulators and antitumoral as well. Finally, the so called compounds are described as products intended for agriculture applications (Courtois, Current Opinion in Microbiology, 2009, 12:261–273).



OOligoTech®®

AAlginate Extraction from biomass

ALG100 Alginate polysaccharides (from Laminaria japonica) Sodium salt alginates extracted and purified from

brown seaweed Laminaria japonica [9005-38-3]

1 g, 10 g, 100 g

ALG101 Alginate polysaccharides (from Fucus vesiculosus) Sodium salt alginates extracted and purified from

brown seaweed Fucus vesiculosus [9005-38-3]

1 g, 10 g, 100 g

ALG102 Alginate polysaccharides (from Ascophyllum nodosum) Sodium salt alginates extracted and purified from

brown seaweed Ascophyllum nodosum [9005-38-3]

1 g, 10 g, 100 g

ALG103 Alginate polysaccharides (from Chorda filum) Sodium salt alginates extracted and purified from

brown seaweed Chorda filum [9005-38-3]

1 g, 10 g, 100 g

ALG104 Alginate polysaccharides (from Durvillaea antarctica) Sodium salt alginates extracted and purified from

brown seaweed Durvillaea antarctica [9005-38-3]

1 g, 10 g, 100 g

ALG105 Alginate polysaccharides Kit Individually packaged Sodium salt alginates

extracted and purified from 5 species of brown seaweeds




OOligoTech®®


ALG300 Guluronate oligosaccharides DP20 (sodium salt) Oligosaccharides prepared by α(1-4) linked L-guluronate block hydrolysis.

Sodium salt. Average Degree of polymerization (DP):20.

M/G ratio<0.25 100 mg, 1 g, 10 g


Sodium salt. Average Degree of polymerization (DP): 10.

M/G ratio<0.25 10 mg, 100 mg, 1 g



M/G ratio<0.25 10 mg, 100 mg, 1 g



M/G ratio<0.30 10 mg, 100 mg, 1 g

Please contact us for custom oligosaccharide length and grade tailored to your need Lower or higher M/G ratio can be obtained on demand

OOH

OH

O

OOH

OH

OOH

OHO

O

-OOC

-OOC

-OOC

OH

OH

G

n



OOligoTech®®


ALG500 Mannuronate oligosaccharides DP20 (sodium salt) Oligosaccharides prepared by β(1-4) linked D-mannuronate block hydrolysis.


M/G ratio>4

100 mg, 1 g, 10 g



M/G ratio>4 10 mg, 100 mg, 1 g







O-OOC OH

OO

OOH

O

HO

HO

-OOC

O-OOC OH

OHO

M

n

Please contact us for custom oligosaccharide length and grade tailored to your need Lower or higher M/G ratio can be obtained on demand



OOligoTech®®

GGalacturronan / Apiogalacturonan Extraction from biomass



OOligoTech®®

GGalacturonan / Apiogalacturonan Extraction from biomass


Pectic polysaccharides are a major part of the plant cell wall. They form a network independent from the hemicellulose/cellulose network and influence cell wall properties such as porosity or tensile strength. Pectins consist of three major structural elements: galacturonan, which is a linear chain of α(1-4)-linked D-galacturonic acids, rhamnogalacturonan I, which consists of a back bone of altering α-1,4-linked galacturonic acid and α(1-2)-linked rhamnose units and the complex rhamnogalacturonan II (RG II). RG II is a well-defined structural element of pectin. It is of low molecular weight. Its 12 different sugars are connected via 20 different linkages. Attached to a backbone of 8–10 galacturonic acid residues rhamnogalacturonan II contains four side chains with rare and therefore diagnostic sugars: 2-O-methyl fucose, 2-O-methyl xylose, apiose, 3-C-carboxy-5-deoxy-L-xylose (aceric acid), 3-deoxy-D-lyxo-2-heptulosaric acid (DHA), and 3-deoxy-D-manno-2-octulosonic acid (KDO).

Apiogalacturonans are present in the walls of some aquatic monocots including Lemna minor and Zostera marina. The backbone is mainly made of α(1-4) linked D-galacturonic acid substituted with single β-D-Apiose and β-D-Apiose-(1-5)-β-D-Apiose side chains at C2/C3 position. In the ramified region of the macromolecule, Arabinose, galactose, xylose and O-Me-Xylose are possible minor components of side chains.


Apple Pectin Lemon Pectin Zostera marina (Apiogalacturonan)

ACTIVITIES AND USES

The main use for galacturonan (pectin) is as a gelling agent, thickening agent and stabilizer in food. They have shown prebiotic activities as dietary fibers, anti-angiogenic and immunomodulatory activities. Oligogalacturonides (OGA) prepared by homogalacturonan hydrolysis (either by chemical or enzymatic): Induce reponse involved in plant defenses (B.L. Ridley et al., 2001. Phytochem., 57; 929–

967) Have bifidogenic, prebiotic properties, inhibit the adherence of bacteria to epithelial

cells, the initial and crucial stage of infection. (DP2-DP7) Stimulate the apoptosis of colon cancer cells Might implicate an additional mechanism of immunologic protection provided by human

milk of the infants (Vos, A. P., Stahl, B., et al. 2007 Pediatric Allergy and Immuno., 18, 304-312)

Apiogalacturonan are used as ingredient intended for skin care.



OOligoTech®®


GAT100 Galacturonate polysaccharides LM from apple (sodium salt) Low methylated α(1-4) linked D-galacturonate extracted and

purified from apple pectins. Sodium salt. Degree of esterification (DE)<5%.

[25990-10-7]

1 g, 10 g, 100 g

GAT101 Galacturonate polysaccharides HM from apple (sodium salt) High methylated α(1-4) linked D-galacturonate extracted and

purified from apple pectins. Degree of esterification (DE)>70%.

[9000-69-5]

1 g, 10 g, 100 g

GAT102 Galacturonate polysaccharides LM from citrus (sodium salt) Low methylated α(1-4) linked D-galacturonate extracted and

purified from apple pectins. Sodium salt. Degree of esterification (DE)<5%.

[9049-37-0]

1 g, 10 g, 100 g

GAT103 Galacturonate polysaccharides HM from citrus (sodium salt) High methylated α(1-4) linked D-galacturonate extracted and

purified from citrus pectins. Sodium salt. Degree of esterification (DE)>65%.

[9046-40-6]

1 g, 10 g, 100 g

O

-OOCO

HO

O

O

-OOCOH

HO

O

OH

O

-OOC

HO

OOH

O

-OOCOH

HO

O

O

MeOOCO

HO

O

O

-OOCOH

HO

O

OH

O

MeOOC

HO

OOH

O

MeOOCOH

HO

O

O

-OOCO

HO

O

O

-OOCOH

HO

O

OH

O

-OOC

HO

OOH

O

-OOCOH

HO

O

O

MeOOCO

HO

O

O

-OOCOH

HO

O

OH

O

MeOOC

HO

OOH

O

MeOOCOH

HO

O



OOligoTech®®


GAT200 Apiogalacturonan polysaccharide (sodium salt) Apiogalacturonan polysaccharide is extracted and purified from Zostera marina.

10 mg, 100 mg, 1 g

GAT300 Rhamnogalacturonan polysaccharide from gombo (sodium salt) Acetylated and galactose branched Rhamnogalaturonate polysaccharide

extracted and purified from Gombo or Okra (Abelmoschus esculentus).

10 mg, 100 mg, 1 g

GAT110 Galacturonan oligosaccharide block (OGAs) α(1-4) linked D-galacturonate oligosaccharides with mixed DP prepared by low

methylated galacturonate polysaccharide hydrolysis. Sodium salt.

Average observed DP: 25

100 mg, 1 g, 10 g

GAT111 Galacturonan oligosaccharides Mixture DP3/DP4 α(1-4) linked D-galacturonate oligosaccharides with mixed DP3/DP4 prepared

by galacturonate polysaccharide hydrolysis. Sodium salt.

HPAEC>99% galacturonic acid

10 mg, 100 mg, 1g

GAT112 Galacturonan oligosaccharides Mixture DP7/DP8 α(1-4) linked D-galacturonate oligosaccharides with mixed DP7/DP8 prepared

by galacturonate polysaccharide hydrolysis. Sodium salt.

HPAEC>99% galacturonic acid

10 mg, 100 mg, 1g

O

-OOCO

HO

O

O

-OOCO

HO

O

O

OHHO

O

O

OH

CH2OH

HO

O

O

-OOC

HO

OOH

O

OH

CH2OH

HO

O

-OOCOH

HO

O




OOligoTech®®

AArabinan Extraction from biomass



OOligoTech®®

AArabinan Extraction from biomass

ARB105 Arabinan polysaccharides from Apple

Linear Arabinan polysaccharide extracted and purified from apple pomace. The polysaccharide is an α(1-5) linked L-arabinose homopolymer.

Arabinose content (HPAEC)>99%

1 g, 10 g, 100 g

O

OH

OH

...O

O

OH

OH

O

O...

n


The L-arabinose-rich polysaccharides are named arabinans. So called polymers have a main structure of α(1-5)-linked L-arabinofuranose units, substituted at either O-2 or O-3 or at both of these positions.

Arabinans are side chains of the complex rhamnogalacturonan I found in the hemicellulosic part of dicotyledonous cell walls also called pectins. Arabinans can also be found as a minor component of the mycobacterial cell walls. In this peculiar case, arabinan glycosidic linkages are α(1-3), α(1-5) and β(1-2) and branched the microbial galactan.


Apple Pomace Olive pomace Sugar beet

ACTIVITIES AND USES

Arabinans were found to be immunobiological active compounds (F. Dourado et al., 2004. Carbohydrate Research 339; 2555–2566) and have hypoglycemic properties. Used as Prebiotic/dietary fibers.



OOligoTech®®

FFructan Extraction from biomass

Inulin



OOligoTech®®


Inulin


Some plants store carbohydrates in the form of inulin as an alternative, or in addition, to starch. Inulins are composed of β(2-1) linked fructose units having a typical terminal glucose. Native inulin encompasses a family of linear structures varying in degree of polymerization (DP) from 3 to 60 (average DP=10). Oligofructose is obtained by partial hydrolysis of inulin and has a small DP ranging from 2 to 8 (average DP=4). Oligofructose nomenclature is given by the formula GFn (Glucose and Fructose number).


Inulins are present in many vegetables and fruits, including onions, leeks, garlic, bananas, asparagus, chicory, and Jerusalem artichokes.

Common chicory Jerusalem artichoke

ACTIVITIES AND USES

This polymer is a recognised source for the production of either ultra-high fructose or oligofructose syrups. Hence, Fructan are widely used in Agrofood industry. Inulin and oligofructose are used to replace fat or sugar and reduce the calories of foods like ice cream, dairy products, confections and baked goods Oligofructose (FOs) is a prebiotic, and its positive effect on human health has been widely acknowledged (e.g. osteoporosis). Oligofructose has approximately 30 to 50 percent of the sweetness of table sugar. Inulin is less soluble than oligofructose and has a smooth creamy texture that provides a fat-like mouthfeel.

Recommended papers: Kaur et al., Applications of inulin and oligofructose in health and nutrition, Journal of

Bioscience, 27 (2002), pp. 703–714. D. Bosscher et al., 2006. International Dairy Journal, 16, 1092–1097.



OOligoTech®®


Inulin

FRU100 Inulin from chicory roots Fruβ(2-1)-[Fruβ(2-1)]35-α(2-1)Glc.

Inulin extracted and purified from chicory roots

[9005-80-5]

1 g, 10 g, 100 g

FRU110 Fructo-oligosaccharides mixture from Jerusalem artichoke (Cut-off< 10 kDa)

Fructo-oligosaccharides prepared by inulin hydrolysis

Purified by 10 kDa cut-off Ultrafiltration 100 mg, 1 g, 10 g

FRU101 1-kestose (DP3) GF2

Fruβ(2-1)-Fruα(2-1)-Glc

C18H32O16 FW 504.43 [470-69-9]

10 mg, 100 mg, 1 g

FRU102 Nystose (DP4) GF3

Fruβ(2-1)-Fruβ(2-1)-Fruα(2-1)-Glc C24H42O21 FW 666.57

[13133-07-8]

10 mg, 100 mg, 1 g

FRU111 Fructo-oligosaccharide DP5 GF4 / Fructofuranosyl-Nystose

Fruβ(2-1)-[Fruβ(2-1)]3-α(2-1)Glc C30H52O26 FW 828.71

10 mg, 100 mg, 1 g

O

OH

O

HO

HOH2C

CH2

O

HO

OH

OH

HO

O

OH

O

HO

HOH2C

CH2OH



OOligoTech®®

FRU112 Fructo-oligosaccharide DP6 GF5 / 1-F-(1-β-fructofuranosyl)-2-nystose


10 mg, 100 mg, 1 g

FRU113 Fructo-oligosaccharide DP7 GF6 / 1-F-(1-β-fructofuranosyl)-3-nystose


10 mg, 100 mg, 1 g

FRU114 Fructo-oligosaccharide DP8 GF7


10 mg, 100 mg, 1 g



NEW 10 mg, 100 mg, 1 g



NEW 10 mg, 100 mg



NEW 10 mg, 100 mg



NEW 10 mg, 100 mg

FRU130 Fructo-Oligosaccharides Kit

Individually packaged Fructo-oligosaccharide kit from 1-kestose (DP2) to Fructo-oligo GF9 (DP10).




OOligoTech®®

SSpirulan Extraction from biomass



OOligoTech®®

SSpirulan Extraction from biomass

SPR100 Spirulan polysaccharides Fine Grade Spirulan polysaccharides are extracted and purified from Arthrospira

platensis.

10 mg, 100 mg, 1 g

O

O

...O OR

HO

O

O

OR

HO

MeO

O

ORO

HO

OHOOC

OH

O

O

OR

HO

O...

R= -O-SO3-


Spirulan (mostly found in its calcium form) is an acidic sulfated polysaccharide extracted from Spirulina (Arthrospira platensis) which is a multicellular, filamentous cyanobacterium, belonging to a blue-green alga of Cyanobacteria.

Spirulan is a sulfated polysaccharide which consists of two types of disaccharide repeating units, O-hexuronosylrhamnose (aldobiuronic acid) and O-rhamnosyl-3-O-methylrhamnose (acofriose) with sulfate groups substituting rhamnose and O-methyl rhamnose at respectively C2 and C4 position, other minor saccharides and sodium ions.


Arthrospira platensis

ACTIVITIES AND USES

Spirulina contains much good-quality protein as well as carotenoids, vitamins, and minerals. It has received attention as a most promising and highly nutritious food source (dietary supplement). It has exhibited various biological activities such as lowering plasma cholesterol levels and blood pressure.

Calcium Spirulan is a potent inhibitor of thrombin through heparin cofactor II (Y. Hayakawa et al., 1997.Biochimica et Biophysica Acta 1355; 241–247) and is thought to enhance antiviral and anti-coagulation effects (J.-B. Lee et al., 2007.Carbohydrate Polymers 69; 651–658).

Recommended paper: J. Yasuhara-Bell, Y. Lu., 2010. Antiviral Research, 86, 231–240.



OOligoTech®®

HHeteroglycan Extraction from biomass



OOligoTech®® HHeteroglycan Extraction from biomass

HGL100 Sulfated heteropolysaccharides native grade Sulfated heteropolysaccharides and beta glucan are extracted and purified

from Caulerpa racemosa 100 mg, 1 g, 10 g

HGL101 Sulfated heteropolysaccharides fine grade Sulfated heteropolysaccharides are extracted from Caulerpa racemosa

and purified by Anion affinity.

Low Glucan content. 10 mg, 100 mg, 1 g


Caulerpa racemosa


Caulerpa racemosa is green seaweed of great interest since it has been highlighted antiviral and biological activity evidences. Extracts from Caulerpa racemosa contain two major polysaccharides which are α(1-4) glucan and sulphated xyloarabinogalactan.

ACTIVITIES AND USES

Antiviral effects (Chattopadhyay et al., 2007. Carbohydrate Polymers, 68; 407–415).



OOligoTech®®

Production by bacterial fermentation

Glycan Oligosaccharides



OOligoTech®®

[email protected] - +33 (0) 4 76 40 71 61



OOligoTech®®

The offer

Production

Analysis and Quality Control

GGlycan oligosaccharides Production by bacterial fermentation

Elicityl develops standardized production processes in a QA/QC policy allowing reproducibility and traceability of production batches.

The products supplied are consistent with internal standards. They are analysed by

adapted and efficient technologies such as HPLC, HPAEC, NMR & Mass spectrometries.

Elicityl produces all OligoTech® oligosaccharides in its own laboratories.

Elicityl develops industrial methods of production based on its expertise in oligosaccharide elaboration, purification and characterization.

Glycan-type bioactive oligosaccharides production is based on the “living factory process”, a unique patented technology consisting in bacterial fermentation of metabolically engineered strains.

Elicityl’s OligoTech® encompasses a collection of almost 200 glycan-type bioactive oligosaccharides involved in key biological pathways (cell adhesion, immunological recognition, embryogenesis, oncogenesis, infection…).

The collection comprises a large diversity of bioactive oligosaccharides such as carbohydrate determinants of human blood groups (ABH, Lewis, P) and carbohydrate portions of the major glycosphingolipids (gangliosides, globosides).

These oligosaccharides have numerous potential applications in different fields as anti-cancer vaccines, anti-infective, anti-neurodegenerative, diagnosis or functional food.

Elicityl also provides Glycobricks®, functionalized oligosaccharides which could be used as elementary building blocks for click chemistry.

The products are available from the mg to the multi-gram scale.



OOligoTech®®

Something to know about our glycans Our glycans are the carbohydrate moiety of complex Glycosphingolipids

Decrypting the Structure and Biosynthesis of Antigens : The main precursors

β1-3

α1-3

Ceramide

β1-3β1-3α2

-6α2-3

α2-3/6

β1-3β1-4

β1-6

α2-3

β1-3 α2-3 α2-8

α2-3α2-8

β1-GlcCer

GalCer

β1-

Phosphosphingolipids

Isoglobo-Series

Globo-Series

Neo-Lacto-Series

Lacto-Series

Ganglio-Series

Our Glycans

Glucose

Galactose

N-AcetylGalactosamine

N-AcetylGlucosamine

N-Acetyl Neuraminic Acid / Sialic Acid

• Modified from the Consortium for Functional Glycomics• CFG nomenclaturehttp://www.functionalglycomics.org/static/consortium/Nomenclature.shtml

β3β1-RType 1

β1-RType 2β4

α1-RType 3β3

β1-RType 4β3

β1-RType 5β4

• Found in N- or O-glycoproteins

• Found in Glycolipids of the Lacto-Series

• Only found in O-Glycans (Core 1 subtype)

• Found in glycolipids of Globo-Series

• Found in glycolipids of Ganglio-Series

• Free lactose or lactosyl ceramide

• Iso & Forssman antigens precursor

Glycan oligosaccharides Production by bacterial fermentation



OOligoTech®® GGlycan oligosaccharides Production by bacterial fermentation

Core Structures We offer a range of glycan from type 1, 2 & 4 core structures. Some of them, namely type 1 and 2 core structures are elementary building blocks for Human (HMO) and mammalian milk oligosaccharides (HMO).

For more information please refer to our Human milk oligosaccharides (HMO) brochure.

Core structures type 1

GLY009 Lacto-N-Biose Galβ1-3GlcNAc C14H25NO11

FW 383.35 [50787-09-2]

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY005 Core type 1 triaose Galβ1-3GlcNAcβ1-3Gal C20H35NO16

FW 545.48

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY010 Lacto-N-tetraose LNT

Galβ1-3GlcNAcβ1-3Galβ1-4Glc C26H45NO21

FW 707.62 [14116-68-8]


O

OH

OH

OHOOH

OH

HOO

OO

OH OHO

OH

NHAc

OHO

OH

OH

HO

OO

OH OHO

OH

NHAc

HO

OH

HO OH

OOH

OH

OH

OO

OH OHO

OH

NHAc

OHO

OH

OH

HO



OOligoTech®®



GLY011 Lacto-N-Triaose LNT2

GlcNAcβ1-3Galβ1-4Glc C20H35NO16

FW 545.48 [75645-27-1]

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY126 Core type 4 Gb5 Triaose core structure

Galβ1-3GalNAcβ1-3Gal C20H35NO16

FW 545.48

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY008 N-Acetyl-D-Lactosamine LacNAc

Galβ1-4GlcNAc C14H25NO11

FW 383.35 [32181-59-2]

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY006 Core type 2 triaose Galβ1-4GlcNAcβ1-3Gal C20H35NO16

FW 545.48

5 mg, 25 mg, 100 mg, 1 g, 5 g

NHAcO

OHO

O

OH

HO

OH

OH

HO OH

AcNHO

OHO

O

OH

HO

OH

OH

HO

O

OH

OH

O

OH

OH

O

OH

O

OH

HO

OHO

OH

NHAc

OH

OO

OH

OH

OH

OH

O

OH

OH

OHOOH

OH

HOO

OOH

NHAc

OHO

OH

HO



OOligoTech®®

GLY021 Lacto-N-neotetraose LNnT / neo-LNT

Galβ1-4GlcNAcβ1-3Galβ1-4Glc

C26H45NO21 FW 707.62

[13007-32-4]

Human Milk Oligosaccharide Boehm et al., 2007 J Nutr Mar;137(3 Suppl 2):847S 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY022 Para-Lacto-N-neohexaose Para-LNnH

Galβ1-4GlcNAcβ1-3Galβ1-4GlcNAcβ1-3Galβ1-4Glc C40H68N2O31 FW 1072.96 [64331-48-2]


GLY023 Lacto-N-neooctaose LNnO

Galβ1-4GlcNAcβ1-3Galβ1-4GlcNAcβ1-3Galβ1-4GlcNAcβ1-3Galβ1-4Glc

C54H91N3O41

FW 1438.29


AcNH

O

OHO

O

OH

OH

HO O

O

OHOH

OHOH

O

OH

OHO OH

AcNHO

OHO

O

OH

HO

OH

OH

HO O

OH

AcNHO

OHO

OO

OHO

OH

OH

HO

OHOH

OHOH

O

OH

OHO OH

AcNHO

OHO

OHO

OH

OH

HO O

AcNHO

OHO

O

OH

HO

OH

OH

HO O

AcNHO

OHO

OO

O

OH

HO

OH

OH

HO

OHOH

OHOH

O

OH

OHO OH




Blood group and Lewis antigens

Product description Histo-Blood groups antigens also called HBGs (A, B, H) and related antigens are complex carbohydrates present on the surface of red blood cells and mucosal epithelium of the respiratory, genitourinary and digestive tracks. They are also present as free oligosaccharides in biologic fluids such as saliva, intestinal content, milk (HMO) and blood.

Secretor phenotype (Se): ABH antigens are expressed along the oro-gastrointestinal mucosal of individuals of positive secretor status. Se individuals express the Secretor-fucosyl transferase FUT2 producing the H antigen.

Non secretor phenotype (Se0): Individuals of non secretor phenotype lack the

secretor-transferase and make shorter Lewisa antigen (Lea)

Bombay phenotype: Individuals lack fucosylated ABH antigens on erythrocytes in circulation (rare phenotype) due to mutation of FUT1 allele.

Further readings:

Marionneau et al. 2001. ABH and Histo-blood Group antigens. Biochimie, 83; 565−573. Tan et al. Norovirus and its HBGA receptors: an answer to historical puzzle. Trends in microbiology,

Vol.13 No.6 (2005) For more information please refer to our HBGA blood group systems brochure

β3/4

FUT3/4

β3/4α2

β3/4α2

β3/4α2

α3

Type 1/2 precursor

H Type 1/2

α3

A or B enzymes

A Type 1/2 B Type 1/2

β3/4α2

α3

BLeb/yALeb/y

α3/4β3/4

α2α3

α3/4

FUT2

FUT3/4

Secretor

Non Secretor

Lewis Leb/y

FUT3/4

αST

Sialyl type 1/ 2

β3/4α2-3α3/4

FUT 3/4

Refer to GLY084-1 & 84-2

SialylLewis Lea/x



OOligoTech®® Blood group H antigens (Blood group O)

GLY030 Blood group H antigen disaccharide Fucα1-2Gal C12H22O10

FW 326.29 [16741-18-7] [24656-24-4]

[146076-26-8]

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY031-1 Blood group H antigen triaose type 1 Fucα1-2Galβ1-3GlcNAc C20H35O15

FW 529.49

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY031-2 Blood group H antigen triaose type 2 Fucα1-2Galβ1-4GlcNAc C20H35O15

FW 529.49

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY031-3 Blood group H antigen triaose type 5 2’Fucosyllactose/ 2’FL

Fucα1-2Galβ1-4Glc C18H32O15 FW 488.43

[41263-94-9]


OO

OH OHO

OH

NHAc

OHHO

O

OOH

OHHO

HO

O

OO

O

O

OH

HO

OHOH

OH

OH

OHHO

HOOH

O

O

O

OH

OH

HO

OH

OH

OHHO

AcNHO

OO

O

O

OH

HO

OH

OH

HO

OH

OHHO

OH



OOligoTech®®

GLY032-1 Blood group H antigen tetraose type 1 Fucα1-2Galβ1-3GlcNAcβ1-3Gal

C26H45NO20

FW 691.62

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY032-2 Blood group H antigen tetraose type 2 Fucα1-2Galβ1-4GlcNAcβ1-3Gal C26H45NO20

FW 691.62

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY127 Blood group H antigen tetraose type 4/ Globo H tetraose Fucα1-2Galβ1-3GalNAcβ1-3Gal C26H45NO20

FW 691.62

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY033-1 Blood group H antigen pentaose type 1 Lacto-N-fucopentaose I (LNFP I)

Fucα1-2Galβ1-3GlcNAcβ1-3Galβ1-4Glc C32H55NO25

FW 853.76 [7578-25-8]


AcNHO

OO

O

O

OH

HO

OH

OH

HO

OH

OHHO

O

OH

OH

O

OH

OH

O

O

O

O

OH

HO

OH

OH

OHHO

OOH

NHAc

OH

OO

OH

OH

OH

OH

O

OH

OH

OHOOH

OH

HOO

OO

OH OHO

OH

NHAc

OHO

O

OOH

OHHO

OH

HO

OOH

OH

OO

OH OHO

OH

NHAc

OHO

O

OOH

OHHO

OH

OHHO



OOligoTech®®

Blood group A antigens

GLY033-2 Blood group H antigen pentaose type 2 Lacto-N-neofucopentaose I (LnNFP I)

Fucα1-2Galβ1-4GlcNAcβ1-3Galβ1-4Glc C32H55NO25 FW 853.76

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY034 Blood group A antigen triaose GalNAcα1-3(Fucα1-2)Gal C20H35NO15

FW 529.49 [49777-13-1]

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY035-1 Blood group A antigen tetraose type 1 GalNAcα1-3(Fucα1-2)Galβ1-3GlcNAc C28H48N2O20

FW 732.68

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY035-2 Blood group A antigen tetraose type 2 GalNAcα1-3(Fucα1-2)Galβ1-4GlcNAc C28H48N2O20

FW 732.68

5 mg, 25 mg, 100 mg, 1 g, 5 g

O

O

O

OH OH

OH

OHHO

OOH

AcHN

OH

O OH

HO

AcNHO

OO

O

O

OH

HO

OH

OH

HO

OH

OHHO

O

O

OHOH

OHOH

O

OH

OHO OH

OO

OH OHO

OH

NHAc

OHHO

O

OOH

OHHO

OOH

AcHN

OH

O

HO

AcHNO

OO

O

O

OH OH

OH

HO

OHOHHO

OOH

AcHN

OH

O

HO

OH



OOligoTech®®

GLY035-3 Blood group A antigen tetraose type 5 GalNAcα1-3(Fucα1-2)Galβ1-4Glc C26H45NO20

FW 691.62 [59957-92-5]

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY035-4 Blood group A Lewisb antigen pentaose type 1 GalNAcα1-3(Fucα1-2)Galβ1-3(Fucα1-4)GlcNAc C34H58N2O24

FW 878.82

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY035-5 Blood group A LewisY antigen pentaose type 2 GalNAcα1-3(Fucα1-2)Galβ1-4(Fucα1-3)GlcNAc C34H58N2O24

FW 878.82

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY036-1 Blood group A antigen pentaose type 1 GalNAcα1-3(Fucα1-2)Galβ1-3GlcNAcβ1-3Gal C34H58N2O25

FW 894.82 [50624-46-9]

5 mg, 25 mg, 100 mg, 1 g, 5 g

O

OO

O

O

OH OH OHOH

OH

HO

OH

OHHO

OOH

AcHN

OH

O

HO

OO

OH OHO

OH

NHAc

OH

O

OOH

OHHO

OOH

AcHN

OH

O

HO

OHO

OHOH

O

AcHNO

OO

O

O

O

OH OH

OH

OHOHHO

OH

OOH

AcHN

OH

O

HOO

HOOH OH

OOH

OH

OO

OH OHO

OH

NHAc

OHO

O

OOH

OHHO

OOH

AcHN

OH

O

HO OH

OH



OOligoTech®®

GLY036-2 Blood group A antigen pentaose type 2 GalNAcα1-3(Fucα1-2)Galβ1-4GlcNAcβ1-3Gal C34H58N2O25

FW 894.82

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY128 Blood group A antigen pentaose type 4 GalNAcα1-3(Fucα1-2)Galβ1-3GalNAcβ1-3Gal C34H58N2O25

FW 894.82

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY037-1 Blood group A antigen hexaose type 1 GalNAcα1-3(Fucα1-2)Galβ1-3GlcNAcβ1-3Galβ1-4Glc C40H68N2O30

FW 1056.96

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY037-2 Blood group A antigen hexaose type 2

GalNAcα1-3(Fucα1-2)Galβ1-4GlcNAcβ1-3Galβ1-4Glc C40H68N2O30

FW 1056.96

5 mg, 25 mg, 100 mg, 1 g, 5 g

AcHNO

OO

O

O

OH OH

OH

HO

OH

OHHO

O

O

OHOH

OHOH

O

OH

OHO OH

OOH

AcHN

OH

O

HO

AcNHO

OO

O

O

OH OH

OH

HO

OH

OHHO

O

OH

OH

O

OH

OH

OOH

AcHN

OH

O

HO

O

O

O

OH OH

OH

OHHO

OOH

OH

OH

OHOO

OH

NHAc

OH

O

OOH

AcHN

OH

O

HO

O

OH

OH

OHOOH

OH

HOO

OO

OH OHO

OH

NHAc

OHO

O

OOH

OHHO

OOH

AcHN

OH

O

HO OH



OOligoTech®® Blood group B antigens

GLY038-1 Blood group B antigen tetraose type 1

Galα1-3(Fucα1-2)Galβ1-3GlcNAc C26H45NO20

FW 691.62

5 mg, 25 mg, 100 mg, 1 g, 5 g


Galα1-3(Fucα1-2)Galβ1-4GlcNAc C26H45NO20

FW 691.62

5 mg, 25 mg, 100 mg, 1 g, 5 g


Galα1-3(Fucα1-2)Galβ1-4Glc

C24H42O20

FW 650.57

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY038-4 Blood group B Lewisb antigen pentaose type 1

Galα1-3(Fucα1-2)Galβ1-3(Fucα1-4)GlcNAc C32H55NO24

FW 837.77

5 mg, 25 mg, 100 mg, 1 g, 5 g

O

OO

O

O

OH

O

OH OHOH

OH

HO

OH

OHHO

OOH

OH

OH

HO

OO

OH OHO

OH

NHAc

OHHO

O

OOH

OHHO

OOH

HO

OH

O

HO

AcNHO

OO

O

O

OH OH

OH

HO

OH

OHHO

OH

OOH

OH

OH

O

HO

OO

OH OHO

OH

NHAc

OH

O

OOH

OHHO

OOH

HO

OH

O

HO

OHO

OHOH

O



OOligoTech®®

GLY038-5 Blood group B LewisY antigen pentaose type 2

Galα1-3(Fucα1-2)Galβ1-4(Fucα1-3)GlcNAc C32H55NO24

FW 837.77

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY039-1 Blood group B antigen pentaose type 1

Galα1-3(Fucα1-2)Galβ1-3GlcNAcβ1-3Gal

C32H55NO25

FW 853.76

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY039-2 Blood group B antigen pentaose type 2

Galα1-3(Fucα1-2)Galβ1-4GlcNAcβ1-3Gal

C32H55NO25

FW 853.76

5 mg, 25 mg, 100 mg, 1 g, 5 g

AcNHO

OO

O

O

OH OH

OH

HO

OH

OHHO

O

OH

OH

O

OH

OH

OOH

OH

OH

O

HO

AcNHO

OO

O

O

O

OH OH

OH

OH

OHHO

OH

OOH

OH

OH

O

HOO

HOOH OH

OOH

OH

OO

OH OHO

OH

NHAc

OHO

O

OOH

OHHO

OOH

HO

OH

O

HO OH

OH



OOligoTech®®

GLY129 Blood group B antigen pentaose type 4

Galα1-3(Fucα1-2)Galβ1-3GalNAcβ1-3Gal C32H55NO25

FW 853.76

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY040-1 Blood group B antigen hexaose type 1

Galα1-3(Fucα1-2)Galβ1-3GlcNAcβ1-3Galβ1-4Glc

C38H65NO30

FW 1015.90

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY040-2 Blood group B antigen hexaose type 2

Galα1-3(Fucα1-2)Galβ1-4GlcNAcβ1-3Galβ1-4Glc C38H65NO30

FW 1015.90

5 mg, 25 mg, 100 mg, 1 g, 5 g

AcNHO

OO

O

O

OH OH

OH

HO

OH

OHHO

O

O

OHOH

OHOH

O

OH

OHO OH

OOH

OH

OH

O

HO

O

O

O

OH OH

OH

OHHO

OOH

OH

OH

O

OOH

NHAc

OH

O

OOH

OH

OH

O

HO

OH

O

OH

OH

OHOOH

OH

HOO

OO

OH OHO

OH

NHAc

OHO

O

OOH

OHHO

OOH

HO

OH

O

HO OH



OOligoTech®® Lewis antigens

GLY049 LewisX (LeX) triaose SSEA-1 / CD15

Galβ1-4(Fucα1-3)GlcNAc C20H35NO15

FW 529.49 [71208-06-5]

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY050 LewisX (LeX) tetraose

Galβ1-4(Fucα1-3)GlcNAcβ1-3Gal

C26H45NO20

FW 691.62

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY051 LewisX (LeX) hexaose Lacto-N-neodifucohexaose (LNnDFH)

Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ1-4(Fucα1-3)Glc

C38H65NO29

FW 999.90

Human Milk Oligosaccharide Kunz et al., 2000. Ann Rev Nutr. 20, 699-722

Product provided for the following study : “Structural basis for the interaction between human milk oligosaccharide and the bacterial lectin PA-IIL of Pseudomonas aeruginosa” Perret S et al., 2005. Biochem J. Jul 15;389. 5 mg, 25 mg, 100 mg, 1 g, 5 g

AcNHO

OHO

O

OH

HO

OH

OH

OH

OHO

OHOH

O

AcNHO

OHO

O

OH

HO

OH

OH

O

OH

OH

O

OH

OH

OHO

OHOH

O

AcNHO

OHO

O

OH

HO

OH

OH

O

O

OH

OH O

O

OH

OOH

OHO

OHOH

OH

OOH

OHHO

OH

O



OOligoTech®®

GLY048 LewisY (LeY) tetraose Fucα1-2Galβ1-4(Fucα1-3)GlcNAc C26H45NO19

FW 675.63 [82993-43-9]

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY052 LewisY (LeY) pentaose Fucα1-2Galβ1-4(Fucα1-3)GlcNAcβ1-3Gal C32H55NO24

FW 837.77

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY046 Lewisa (Lea) triaose

Galβ1-3(Fucα1-4)GlcNAc C20H35NO15

FW 529.49 [56570-03-7]

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY054 Lewisa (Lea) tetraose

Galβ1-3(Fucα1-4)GlcNAcβ1-3Gal C26H45NO20

FW 837.77

5 mg, 25 mg, 100 mg, 1 g, 5 g

AcNHO

OO

O

O

OH

HO

OH

OH

OH

OHHO

OH

OHO

OH OH

O

AcNHO

OO

O

O

OH

HO

OH

OH

OH

OHHO

O

OH

O

OH

OH

OHO

OH OH

OH

O

OOH

OH

OO

OH OHO

OH

NHAc

OO

OH

OH

OHHO

O

OH OH

HO

OO

OH OHO

OH

NHAc

OHO

OH

HO

O

OH OH

HO



OOligoTech®®

GLY055 Lewisa (Lea) hexaose Lacto-N-difucohexaose II (LNDFH II)

Galβ1-3(Fucα1-4)GlcNAcβ1-3Galβ1-4(Fucα1-3)Glc

C38H65NO29

FW 999.90 [62258-12-2]


GLY045 Lewisb (Leb) tetraose

Fucα1-2Galβ1-3(Fucα1-4)GlcNAc C26H45NO19

FW 675.63 [80081-06-7]

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY056 Lewisb (Leb) pentaose

Fucα1-2Galβ1-3(Fucα1-4)GlcNAcβ1-3Gal C32H55NO24

FW 837.77

Receptor of gastric pathogenic strain Becker DJ, Lowe JB. 2003. Glycobiology. Jul; 13(7): 41R-53R 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY047 Sialyl LewisX (sLeX) tetraose Sodium salt

Neu5Acα2-3Galβ1-4(Fucα1-3)GlcNAc C31H51N2O23Na FW 842.72

[98603-84-0]

5 mg, 25 mg, 100 mg, 1 g, 5 g

O

OHOHO

OH

OH

O

OO

OH OHO

OH

NHAc

O

OH

OH

HO

OH

O

OH OH

HO

O

O

OH OH

HO

O

OOH

OH

OO

OH OHO

OH

NHAc

O

OH

OHHO

O

OH OH

HO

O

OOH

OHHO

O

OO

OH OHO

OH

NHAc

OHHO

O

OH OH

HO

O

OOH

OHHO

O

AcNHO

OHO

O

OH OH

OH

OH

OHO

OHOH

OO

O

OHAcHN

HOOH

HO

HOOC



OOligoTech®®

GLY053 Sialyl LewisX (sLeX) pentaose Sodium salt

Neu5Acα2-3Galβ1-4(Fucα1-3)GlcNAcβ1-3Gal C37H61N2O28Na FW 1004.86

Ligand of selectin-dependent leukocyte adhesion Berg EL et al,. 1991. J Biol Chem. 266(23):14869-72

Tumor-associated-antigen (TACA) Magnani JL. 1991. Glycobiology. Sep;1(4):318-20 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY044 Sialyl Lewisa (sLea) tetraose Sodium salt Neu5Acα2-3Galβ1-3(Fucα1-4)GlcNAc C31H51N2O23Na

FW 842.73 [92448-22-1]

5 mg, 25 mg, 100 mg, 1 g, 5 g

AcNHO

OHO

O

OH OH

OH

O

OH

OH

O

OH

OH

OHO

OHOH

OO

O

OHAcHN

HOOH

HO

HOOC

O

O

OH OHO

OH

NHAc

OHO

OH

O

OHOH

HO

OO

OHAcHN

HOOH

HO

HOOC




Fucosylated oligosaccharides

Lacto-Series

GLY060 3 Fucosyllactose 3-FL

Galβ1-4(Fucα1-3)Glc C18H32O15 FW 488.43

[41312-47-4]

Human Milk Oligosaccharide Kunz et al., 2000. Ann Rev Nutr. 20, 699-722.

Product provided for the following study : “Structural basis for the interaction between human milk oligosaccharide and the bacterial lectin PA-IIL of Pseudomonas aeruginosa” Perret S et al., 2005. Biochem J. Jul 15;389

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY066 Lactodifucotetraose Difucosyllactose / DF-L

Fucα1-2Galβ1-4(Fucα1-3)Glc C24H42O19

FW 634.57 [20768-11-0]

Human Milk Oligosaccharide Kunz et al., 2000. Ann Rev Nutr. 20, 699-722.

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY063 3’Sialyl-3Fucosyllactose F-SL

Sodium salt

Neu5Acα2-3Galβ1-4(Fucα1-3)Glc C29H48NO23Na FW 801.67

Human Milk Oligosaccharide Kunz et al., 2000. Ann Rev Nutr. 20, 699-722. 5 mg, 25 mg, 100 mg, 1 g, 5 g

O

OO

OH OHOH

OH

O

OHHO

OH

OH

OH

HOO

O

OO

OH OHOH

OH

O

OHHO

OH

OH

OH

OO

O

OHAcHN

HOOH

HO

HOOC

O

OO

O

O

OH

HO

OHOH

OH

OH

OHHO

OH

O

OHO

OHOH



OOligoTech®®

“3-Fucosyllactose core” Oligosaccharides

GLY061 Lacto-N-neofucopentaose LNnFP-V/LNFP VI

Galβ1-4GlcNAcβ1-3Galβ1-4(Fucα1-3)Glc C32H55NO25

FW 853.76

Human milk oligosaccharide Kunz et al., 2000. Ann Rev Nutr. 20, 699-722. Rosenstein et al., 1992. Infect. Immun. 60:5078-5084.

Product provided for the following study : Perret S et al., 2005. Biochem J. Jul 15;389.

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY062 Lacto-N-fucopentaose V LNFP V

Galβ1-3GlcNAcβ1-3Galβ1-4(Fucα1-3)Glc C32H55NO25

FW 853.76 [60254-64-0]

Human Milk Oligosaccharide Kunz et al., 2000. Ann Rev Nutr. 20, 699-722. 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY064 α1-3Galactosyl-3Fucosyllactose Galα1-3Galβ1-4(Fucα1-3)Glc C24H42O20

FW 650.57

5 mg, 25 mg, 100 mg, 1 g, 5 g

O

OO

OH OHOH

OH

O

OHHO

OH

OH

OH

O

OOH OH

HO

HO

O

AcNHO

OHO

O

OH

HO

OH

OH

O

O

OH

OH

OO

OH

OOH

HO

OH

O OH

OH

HO

OH

O

OH

OH

OHOOH

OH

O

OO

OH OHO

OH

NHAc

OHO

OH

OH

HOO

OHO

OH OH



OOligoTech®®

GLY065 α1-4Gal-3Fucosyllactose Galα1-4Galβ1-4(Fucα1-3)Glc C24H42O20

FW 650.57

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY067 3-Fucosylated Blood group A tetraose GalNAcα1-3(Fucα1-2)Galβ1-4(Fucα1-3)Glc C32H55NO24

FW 837.77

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY068 3-Fucosylated Blood group B tetraose Galα1-3(Fucα1-2)Galβ1-4(Fucα1-3)Glc C30H52O24

FW 796.71

5 mg, 25 mg, 100 mg, 1 g, 5 g

O

OO

OHOH

OH

O

OHHO

OH

OH

OH

O

OOH OH

HO

HO

O

HO

O

OO

O

O

OH

O

OH OHOH

OH

OH

OHHO

OOH

AcHN

OH

HO

O

OHHO

OH

O

O

OO

O

O

OH

O

OH OHOH

OH

OH

OHHO

OOH

OH

OH

HO

O

OHHO

OH

O



OOligoTech®®

Xeno and Galili antigens are major antigens responsible for the hyperacute rejection and identified as α-galactosyl epitopes. The first one identified was the Linear-B trisaccharide (Galili et al. 1985, 1987) namely Galα1-3Galβ1-4GlcNAc.

α-Gal epitopes are abundantly expressed on cells of non-primate mammals and new world monkeys whereas humans, apes and old world monkeys lack this epitope but produce against it large amounts of antibodies anti-Gal. This interaction between them is of major clinical significance causing rejection of pig organ transplants in human and monkeys (Zhao Chun chen et al., Glycobiology,vol.11, 2001).

Further Reading(s): Caroline Gebus et al. Carbohydrate research, 2012.

Galili & Xeno antigens

GGlycan ooligosaccharides Production by bacterial fermentation

Galα-3Gal oligosaccharides

GLY074-1 Xeno antigen type 1

Galα1-3Galβ1-3GlcNAc

C20H35NO16

FW 545.48

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY074-2 Xeno antigen type 2 Galili antigen triaose/Galα-3 epitope/Linear B-2 trisaccharide

Galα1-3Galβ1-4GlcNAc C20H35NO16

FW 545.48

Major porcine antigen responsible for xenograft rejection. Sarkar et al., Carbohydrate Research. 1992. 233 245-50. Ligand for Bovine Norovirus Newbury2 Expected to Prevent Cross-Species Transmission. Zakhour M, et al. (2009) PLoS Pathog 5(7): e1000504. 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY071 Galili antigen pentaose

Galα1-3Galβ1-4GlcNAcβ1-3Galβ1-4Glc

C32H55NO26

FW 869.76

5 mg, 25 mg, 100 mg, 1 g, 5 g

OO

OH OHO

OH

NHAc

OH

OH

HO

OOH

OH

OH

O

HO

O

NHAc

OH

OHOOH

OH

HOO

OOH

OH

OH

O

OHHO

AcNHO

OHO

OO

O

OH OH

OH

HO

OHOH

OHOH

O

OH

OHO OH

HOO

OH

OH

OH

O



OOligoTech®®

GLY077 Galili antigen heptaose

Galα1-3[Galβ1-4GlcNAcβ1-3]2Galβ1-4Glc C46H78N2O36

FW 1235.09

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY078 Galili antigen nonaose


FW 1600.42

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY079 Galili antigen undecaose


FW 1964.76

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY075 Xeno lewisX / α-Gal-LewisX

Galα1-3Galβ1-4(Fucα1-3)GlcNAc C26H45NO20

FW 691.62

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY076 Xeno Lewisa / α-Gal-Lewisa

Galα1-3Galβ1-3(Fucα1-4)GlcNAc C26H45NO20

FW 691.62

5 mg, 25 mg, 100 mg, 1 g, 5 g

OO

OH OHO

OH

NHAc

OH

OH

O

O

OH OH

HOO

OH

OH

OH

O

HO

O

NHAc

OH

OHOOH

OH

O

OOH

OH

OH

O

OHHOO

HO

OHOH

O

AcNHO

OHO

OO

O

OH OH

OH

HO

OHOH

OHOH

O

OH

OHO OH

HOO

OH

OH

OH

O

2

AcNHO

OHO

OO

O

OH OH

OH

HO

OHOH

OHOH

O

OH

OHO OH

HOO

OH

OH

OH

O

3

AcNHO

OHO

OO

O

OH OH

OH

HO

OHOH

OHOH

O

OH

OHO OH

HOO

OH

OH

OH

O

4



OOligoTech®® Isoglobo-Series

GLY070 Isoglobotriaose iGb3/ linear B-6 trisaccharide

Galα1-3Galβ1-4Glc

C18H32O16

FW 504.43 [56038-36-9]

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY072 Isoglobotetraose iGb4 / Cytolipin R

GalNAcβ1-3Galα1-3Galβ1-4Glc C26H45NO21

FW 707.62 [75645-26-0]

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY073 Isoglobopentaose / iGb5

Galβ1-3GalNAcβ1-3Galα1-3Galβ1-4Glc C32H55NO26

FW 869.76

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY134 Isoforssman antigen pentaose

GalNAcα1-3GalNAcβ1-3Galα1-3Galβ1-4Glc C34H58N2O26 FW 910.82

5 mg, 25 mg, 100 mg, 1 g, 5 g

O

OH

OH

OHOOH

OH

HOO

OOH

OH

OH

O

OHO

OH

NHAc

OH

O

OO

OH OH

OH

HO

O

OH

OH

OHOOH

OH

HOO

OOH

OH

OH

O

OHHO

OOH

NHAc

OH

O

O

OH

OH

OHOOH

OH

HOO

HOO

OH

OH

OH

O

OH

OOH

NHAc

O

OH

OH

OH

OH

O

OOH

OH

OH

OOH

OH

HOO

HO

OOH

NHAc

OH

O

O

OH



OOligoTech®®

Type 1


Sialylated oligosaccharides

GLY084-1 Sialylated triaose type 1 Sialyl Lea precursor

Sodium salt

Neu5Acα2-3Galβ1-3GlcNAc C25H41N2O19Na FW 696.58

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY080 Sialylated tetraose type 1 Sodium salt Neu5Acα2-3Galβ1-3GlcNAcβ1-3Gal C31H51N2O24Na

FW 858.72

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY085-1 Disialylated tetraose type 1 Sodium salt NeuAcα2-8Neu5Acα2-3Galβ1-3GlcNAc C36H57N3O27Na2

FW 1009.81

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY086-1 Trisialylated pentaose type 1 Sodium salt NeuAcα2-8NeuAcα2-8Neu5Acα2-3Galβ1-3GlcNAc C47H73N4O35Na3

FW 1323.05

5 mg, 25 mg, 100 mg, 1 g, 5 g

O

OH

OH

OO

OH OHO

OH

NHAc

OHO

OH

OH

OHOO

OHAcHN

HOOH

HO

HOOC

OO

OH OHO

OH

NHAc

OHHO

OH

O

OHAcHN

HOOH

HOO

HOOC

O

OHAcHN

HOHO

HOOCOO

OHAcHN

HOOH

HO

HOOC

OO

OH OHO

OH

NHAc

OHHO

OH

O

O

OHAcHN

HOHO

HOOCOO

OHAcHN

HOHO

HOOCOO

OHAcHN

HOOH

HO

HOOC

OO

OH OHO

OH

NHAc

OHHO

OH

O



OOligoTech®®

Type 2

GLY081 LS-Tetrasaccharide a (LSTa) Sialyl-lacto-N-tetraose a

Sodium salt

Neu5Acα2-3Galβ1-3GlcNAcβ1-3Galβ1-4Glc

C37H61N2O29Na

FW 1020.86 [64003-58-5]

Human milk oligosaccharide Kunz et al., 2000. Ann Rev Nutr. 20, 699-722 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY172 Disialylated pentaose type 1 Sodium salt

NeuAcα2-8Neu5Acα2-3Galβ1-3GlcNAcβ1-3Gal C42H67N3O32Na2

FW 1171.95

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY084-2 Sialylated triaose type 2 3’-α-sialyl-N-Acetyl-Lactosamine/ Sialyl Le x precursor

Sodium salt

Neu5Acα2-3Galβ1-4GlcNAc C25H41N2O19Na FW 696.58

[81693-22-3]

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY082 Sialylated tetraose type 2 Sodium salt

Neu5Acα2-3Galβ1-4GlcNAcβ1-3Gal

C31H51N2O24Na

FW 858.72

5 mg, 25 mg, 100 mg, 1 g, 5 g

NHAc

O

OHO

O

OH OH

OH

HO OHO

OHAcHN

HOOH

HOO

HOOC

O

OH

OH

OHOOH

OH

HOO

OO

OH OHO

OH

NHAc

OHO

OH

OH

OO

OHAcHN

HOOH

HO

HOOC

O

OH

O

OH OHO

OH

NHAc

HOO

OOH

OH

OH

OHOO

OHAcHN

HOHO

HOOCOO

OHAcHN

HOOH

HO

HOOC

AcNHO

OHO

O

OH OH

OH

HO

O

OH

OH

O

OH

OHO

O

OHAcHN

HOOH

HO

HOOC



OOligoTech®®

GLY085-2 Disialylated tetraose type 2 Sodium salt NeuAcα2-8Neu5Acα2-3Galβ1-4GlcNAc C36H57N3O27Na2

FW 1009.81

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY086-2 Trisialylated pentaose type 2 Sodium salt NeuAcα2-8NeuAcα2-8Neu5Acα2-3Galβ1-4GlcNAc C47H73N4O35Na3

FW 1323.05

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY083 LS-Tetrasaccharide d (LSTd) Sialyl-lacto-N-tetraose d

Sodium salt

Neu5Acα2-3Galβ1-4GlcNAcβ1-3Galβ1-4Glc

C37H61N2O29Na

FW 1020.86 [100789-83-1]

5 mg, 25 mg, 100 mg, 1 g, 5 g

O

OH

OH OH OOH

NHAcO

OOH

OHO

OHAcHN

HOOH

HO

O

O

HOOC

HO

O

OH

OOH

OH

OHHO

NHAcO

OHO

O

OH OH

OH

HO OHO

OHAcHN

HOHO

O

HOOCOO

OHAcHN

HOOH

HO

HOOC

O

OHAcHN

HOHO

HOOCOO

OHAcHN

HOHO

HOOCOO

OHAcHN

HOOH

HO

HOOC

NHAcO

OHO

O

OH OH

OH

HO OHO




Ganglioside sugars (Ganglio-Series)

Product description Gangliosides are complex glycosphingolipids (abbreviated GSL and also called glycolipids) that contain a sialic acid. They are buildings blocks of cell membrane of vertebrates and play key roles in cell to cell and cell to extracellular matrix communication (receptors for toxin, hormone, virus…) As part of tumor pathogenesis, these molecules are proposed as vaccine targets.

Ganglioside sugar Nomenclature: G stands for Ganglioside M, D, T & Q stands for mono, di, tri, quadri number of sialic acids 1, 2 3 as the order of distance migration in thin layer chromatography

Further readings:

J. Heimburg-Molinaro et al., Vaccine 29 (2011) 8802-8826. S. Hakomori. Biochimica etBiophysica Acta 1780 (2008) 325-346. For more information please refer to our Tumor-associated carbohydrate antigens

(TACA) brochure

GlcCer

β4

GM3

GD3

GT3

α8 α8 α3

α8 α3

α3

β4

β4

β4

LacCer

c-seriesGangliosides

b-seriesGangliosides

a-seriesGangliosides

GT2 GT1c GQ1c

GD2 GD1b GT1b

GM2 GM1a GD1a GT1a

β4

β4

GA2

β4

β4

GA1

β3

GM1b GD1c

GQ3

Modified from Essentials of Glycobiology 2nd EditionVarki A, Cummings RD, Esko JD, et al., editors.Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009.



OOligoTech®®

GLY090 GM3 Ganglioside sugar 3'Sialyllactose

Sodium salt

Neu5Acα2-3Galβ1-4Glc C23H38NO19Na

FW 655.53 [35890-38-1]

Human Milk Oligosaccharide Kunz et al., 2000. Ann Rev Nutr 20, 699-722

Product provided for the following study: “Chemoenzymatic synthesis of GM3 and GM2 gangliosides containing a truncated ceramide functionalized for glycoconjugate synthesis and solid phase applications”. Jacques S et al,. 2006. Org Biomol Chem. 2006 Jan 7;4(1):142-54 100 mg, 1 g, 5 g

GLY091 GD3 Ganglioside sugar Disialyl lactose / DS-L

Sodium salt

Neu5Acα2-8Neu5Acα2-3Galβ1-4Glc C34H54N2O27Na2

FW 968.76

Tumor-associated carbohydrate antigen (TACA) Birkle S et al. 2003. Biochimie. 85(3-4): 455-63

Bovine Milk & Colostrum P. K. Gopal et al. British Journal of Nutrition (2000), 84, Suppl 1, S69-S74 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY092 GT3 Ganglioside sugar Trisialyl lactose

Sodium salt

Neu5Acα2-8Neu5Acβ2-8Neu5Acα2-3Galβ1-4Glc C45H70N3O35Na3 FW 1282.00

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY105 GQ3 Ganglioside sugar Quadrisialyl lactose

Sodium salt

Neu5Acα2-8Neu5Acα2-8Neu5Acβ2-8Neu5Acα2-3Galβ1-4Glc C56H86N4O43Na4 FW 1595.23

5 mg, 25 mg, 100 mg, 1 g, 5 g

OO

OHAcHN

HOHO

HOOC

O

OHO

O

OH OH OHOH

OH

HO

OO

OHAcHN

HOOH

HO

HOOC

OO

OHAcHN

HOHO

HOOC

O

OHO

O

OH OHOH

OH

HO

OO

OHAcHN

HOHO

HOOCOO

OHAcHN

HOOH

HO

HOOC

OH

OO

OHAcHN

HOOH

HO

HOOC

O

OHO

O

OH OH OHOH

OH

HO

OO

OHAcHN

HOHO

HOOC

O

OHO

O

OH OHOH

OH

HO

OO

OHAcHN

HOHO

HOOCOO

OHAcHN

HOHO

HOOC

OH

OO

OHAcHN

HOOH

HO

HOOC



OOligoTech®®

GLY093 GM2 Ganglioside sugar Sodium salt

GalNAcβ1-4(Neu5Acα2-3)Galβ1-4Glc C31H51N2O24Na FW 858.72

Tumor-associated carbohydrate antigen (TACA) Birkle S et al. 2003. Biochimie. 85(3-4): 455-63 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY094 GD2 Ganglioside sugar Sodium salt

GalNAcβ1-4(Neu5Acα2-8Neu5Acα2-3)Galβ1-4Glc C42H67N3O32 Na2 FW 1171.95

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY095 GT2 Ganglioside sugar Sodium salt

GalNAcβ1-4(Neu5Acα2-8Neu5Acα2-8Neu5Acα2-3)Galβ1-4Glc C53H83N4O40 Na3

FW 1485.19

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY096 GM1a Ganglioside sugar Sodium salt

Galβ1-3GalNAcβ1-4(Neu5Acα2-3)Galβ1-4Glc C37H61N2O29 Na FW 1020.86 [67063-78-9]

Product provided for this study: “Solid phase immunoadsorption for therapeutic and analytical studies on neuropathy-associated anti-GM1 antibodies” Townson K et al,. Glycobiology. 2007 Mar;17(3):294-303

5 mg, 25 mg, 100 mg, 1 g, 5 g

O

OH

OH

OHHOO

OH

OHO

NHAc

OOH

HO

O

HO

OO

OH

AcHN

HO

HO

HOOCOH

OO

OHAcHN

HOHO

HOOC

O

OHO

O

OH OHOH

OH

HO

OO

OHAcHN

HOHO

HOOCOO

OHAcHN

HOOH

HO

HOOC

NHAc

OOH O

HO

HO

O

OH

OH

OHHOOOH

OHO

NHAc

OOH

HO

OHO

OO

OHAcHN

HO

HO

HOOCOO

OHAcHN

HOOH

HO

HOOC

O

OH

OH

HOO

OH

OHO

NHAc

OOH OHO

OO

OH

AcHN

HO

HO

HOOCOH

O

OH

OH

HO

OHO

OH



OOligoTech®®

GLY097 GM1b Ganglioside sugar Sodium salt

Neu5Acα2-3Galβ1-3GalNAcβ1-4Galβ1-4Glc

C37H61N2O29Na FW 1020.86

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY098 GD1a Ganglioside sugar Sodium salt

Neu5Acα2-3Galβ1-3GalNAcβ1-4(Neu5Acα2-3)Galβ1-4Glc

C48H77N3O37Na2

FW 1334.09

Functional ligands for myelin stability and the control of nerve regeneration Vyas, A et al., 2001. Biochimie. 83(7): 677-82. 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY099 GD1b Ganglioside sugar Sodium salt

Galβ1-3GalNAcβ1-4(Neu5Acα2-8Neu5Acα2-3)Galβ1-4Glc C48H77N3O37Na2 FW 1334.09

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY100 GT1a Ganglioside sugar Sodium salt

Neu5Acα2-8Neu5Acα2-3Galβ1-3GalNAcβ1-4(Neu5Acα2-3)Galβ1-4Glc

C59H93N4O45Na3

FW 1647.33

5 mg, 25 mg, 100 mg, 1 g, 5 g

O

OH

OH

OHHOOOH

O

NHAc

OOH

OH

OOH

O

O

O

OHAcHN

HOHO

HOOCOH

OO

OHAcHN

HOHO

HOOCOH

O

OH

OHOH

O

OH

OH

OHHOOOH

OHO

NHAc

OOH

OOH

OOHOH

O

HO

OO

OHAcHN

HOHO

HOOCOH

OH

AcNH

OHO OH

O

O

OHOH

OH OH

OHO OH

O

O

O

OHAcHN

HOHO

HOOCOH

O

OH

OHOH

OOO

OHAcHN

HOHO

HOOCOO

HOAcHN

HOHO

HOOCOH

O

OH

OH

OHHOOOH

OHO

NHAc

OOH OHO

OO

OH

AcHN

HO

HO

HOOC

OH

OOH

HO

OHO

OO

OH

AcHN

HO

HO

HOOCOH



OOligoTech®®

GLY101 GT1c Ganglioside sugar Sodium salt

Galβ1-3GalNAcβ1-4(Neu5Acα2-8Neu5Acα2-8Neu5Acα2-3)Galβ1-4Glc

C59H93N4O45Na3

FW 1647.33

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY102 aGM1 (asialo GM1) Ganglioside sugar / GA1 Galβ1-3GalNAcβ1-4Galβ1-4Glc

C26H45NO21 FW 707.62

[75645-24-8]

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY103 Fucosyl GM1 Ganglioside sugar Sodium salt

Fucα1-2Galβ1-3GalNAcβ1-4(Neu5Acα2-3)Galβ1-4Glc C43H71N2O33Na FW 1168.00

Tumor associated carbohydrate antigen expressed in small cell lung cancer (TACA) Dickler. MN et al,. Clin Cancer Res. 1999. Oct ; 5(10): 2773-9 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY104 aGM2 (asialo GM2) Ganglioside sugar / GA2 GalNAcβ1-4Galβ1-4Glc C20H35NO16

FW 545.48

5 mg, 25 mg, 100 mg, 1 g, 5 g

AcNH

OOH

O

O

OHOH

OH OH

OHO OH

O

O

OHAcHN

HOHO

HOOCOO

HOAcHN

HOHO

HOOCOO

HOAcHN

HOOH

HO

HOOC

O

OH

OHOH

OHO O

OH

O

OH

OH

OHHOOOH

OHO

NHAc

OOH

OOH

OOH

HO O

HOOHHO

O

OH

OH

OHHOOOH

OH

O

NHAc

O

OH

O

HO

HO

HO

O

O

OH

O

OH

OH

OHHOOOH

OHO

NHAc

OOH OHO

OO

OH

AcHN

HO

HO

HOOCOH

OOH

HO

OHO

HO

OH




Globo-Series (P antigens)

Product description Globosides are major components of human erythrocytes and were termed like this since it was obtained as a globular precipitate. Glycosphingolipids (GLS’s) of the globo-series are membrane-associated antigens possessing as structural feature a Galα1-4Gal (galabiose-like) linkage which is responsible for their specific roles in recognition and cell differentiation. They are recognized by proteins of pathogenic E. coli in human epithelial cells of the urinary tract. They are also receptors for Shiga toxin and verotoxin (Shiga-like toxin) and constitute the basis of the P-blood group system. Many of them have been described as tumor-associated antigens.

Galα1-4Galβ1-4Glc

The inner carbohydrate core structure of all globo-series GSL

The P blood group antigens are expressed on glycolipids of the red cell membrane and in tissues, including the urothelium.

The stage specific embryogenic antigens (also known as SSEA) are highly expressed in

early embryo or embryonal carcinoma of mouse, primates and humans and are assumed to be important functional molecules involved in defining stage of stem cell development.

The Forssman antigens are glycolipids that very closely resembles the Globo H antigen as

they share an identical Gb4 tetrasaccharide core. It is species specific as expressed in some mammals (e.g., sheep, dogs, horses, etc.) but not in others (rabbits, pigs, humans, etc.). Interestingly, it is present in several forms of human cancers making it a potential candidate for cancer therapy.

Further readings: A.J. Wright, P.W. Andrews. Stem Cell Research (2009) 3, 3-11. For more information please refer to our Tumor-associated carbohydrate antigens

(TACA) brochure

N-Acetyl Neuraminic Acid / Sialic Acid

Sialyl-Globopentaose Gb5SSEA-4

Globopentaose Gb5SSEA-3a

Globotetraose Gb4P antigen

Globotriaose Gb3Pk antigen

β4α4β3β3α2-3

α2

Globo-HSSEA-3b

Glucose

Galactose

N-AcetylGalactosamine

N-AcetylGlucosamine

Fucose

CFG nomenclaturehttp://www.functionalglycomics.org/static/consortium/Nomenclature.shtml

β1-Ceramide



OOligoTech®® P Blood group antigens & Analogues

GLY120 Globotriaose (Gb3) Pk antigen

Galα1-4Galβ1-4Glc

C18H32O16

FW 504.43 [66580-68-5]

Tumor associated antigen expressed in Burkitt's lymphoma (TACA) Wiels J et al., 1984. J Biol Chem. Dec 10;259(23):14783-7 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY121 Globotetraose (Gb4) P antigen

GalNAcβ1-3Galα1-4Galβ1-4Glc

C26H45NO21 FW 707.62

[75660-79-6]

Receptor of B19 parvovirus Brown KE et al,. 1993. Science. 262 :114-117. 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY135 Globotriaose analogue type 1 Galα1-4Galβ1-3GlcNAc C20H35NO16

FW 545.48

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY136 Globotriaose analogue type 2/ P1 antigen Galα1-4Galβ1-4GlcNAc C20H35NO16

FW 545.48

5 mg, 25 mg, 100 mg, 1 g, 5 g

O

OH

OH

OH

OOH

OH

OH

OOH

OH

O

HOHO

O

HO

OO

OHO

OH

NHAc

OH

OH

HOHO

OOH

OH

OH

O

HO

O

NHAc

OH

OH

OOH

OH

OH

OOH

OH

O

HOHO

O

HO

HOO

OH

NHAc

O

OH

OH

OH

OH

OO

OH

OH

OH

OOH

OH

O

HOHO

O



OOligoTech®®

Globo-Series (Core structure type 4)

GLY171 Sialylated globotriaose/ 3Sialyl-Gb3 Sodium salt

Neu5Acα2-3Galα1-4Galβ1-4Glc

C29H48NO24Na FW 817.67

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY127 Globo-H tetraose / Blood group H antigen tetraose type 4 Fucα1-2Galβ1-3GalNAcβ1-3Gal C26H45NO20

FW 691.62

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY124 Globo-A heptaose

GalNAcα1-3(Fucα1-2)Galβ1-3GalNAcβ1-3Galα1-4Galβ1-4Glc C46H78N2O35 FW 1219.09

Tumor associated antigen expressed in human kidney cancer (TACA) Breimer, M. and Jovall, P.A. 1985. FEBS Lett. 179, 165-172 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY125 Globo-B heptaose

Galα1-3(Fucα1-2)Galβ1-3GalNAcβ1-3Galα1-4Galβ1-4Glc C44H75NO35 FW 1178.04

5 mg, 25 mg, 100 mg, 1 g, 5 g

O

O

O

OH OH

OH

OHHO O

OH

OH

OH

OOH

OH

OH

OOH

OH

O

HOO

OO

OH

NHAc

OH

O

HO

OOH

OH

OH

O

HO

O

O

O

OH OH

OH

OHHO O

OH

OH

OH

OOH

OH

OH

OOH

OH

O

HOO

OO

OH

NHAc

OH

O

HO

OOH

AcHN

OH

O

O

O

O

O

OH

HO

OH

OH

OHHO

OOH

NHAc

OH

OO

OH

OH

OH

OH

O

OH

OH

OH

OO

OH

OH

OH

OOH

OH

O

HOHOO

O

OHAcHN

HOOH

HO

HOOC



OOligoTech®® Stage-specific embryonic antigens (SSEA-3 & 4)

GLY122 Globopentaose (Gb5) Stage Specific Embryonic Antigen 3a (SSEA-3a)

Galβ1-3GalNAcβ1-3Galα1-4Galβ1-4Glc

C32H55NO26

FW 869.76 [71937-76-3]

Tumor associated antigen expressed in testicular cancer (TACA) Olie et al,. Br J Cancer. 1996. 74, 133-140 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY123 Globo-H hexaose Stage Specific Embryonic Antigen 3b (SSEA-3b)

Fucα1-2Galβ1-3GalNAcβ1-3Galα1-4Galβ1-4Glc C38H65NO30

FW 1015.90

Tumor associated antigen expressed in various types of cancer (breast, prostate, ovarian) Zhang et al., 1998. Clin Cancer Res. Feb; 4(2):295-302 Hakomori. 1990. Hum. Canc Immunol. 10:781-802 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY130 SSEA-4 tetraose Stage-Specific Embryonic Antigen-4

Sodium salt

Neu5Acα2-3Galβ1-3GalNAcβ1-3Gal C31H51N2O24Na FW 858.72

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY131 SSEA-4 hexaose Stage-Specific Embryonic Antigen-4

Sodium salt

Neu5Acα2-3Galβ1-3GalNAcβ1-3Galα1-4Galβ1-4Glc

C43H71N2O34Na FW 1183.00

5 mg, 25 mg, 100 mg, 1 g, 5 g

O

OH

O

OH

O

OHO

OH

NHAc

O

OH

OH

OH

OH

OO

OH

OH

OH

OOH

OH

O

HOHOO

O

OH

COOH

AcHN

HOOH

HO

O

OH

O

OH

O

OHO

OH

NHAc

OH

OO

OH

OH

OH

O

OH

COOH

AcHN

HOOH

HOOH

O

OH

O

OH

HO

OHO

OH

NHAc

O

OH

OH

OH

OH

OO

OH

OH

OH

OOH

OH

O

HOHOO

O

O

O

O

OH

HO

OH

OH

OHHO

OOH

NHAc

O

OH

OH

OH

OH

OO

OH

OH

OH

OOH

OH

O

HOHOO



OOligoTech®®

Forssman antigens

GLY132 Forssman antigen pentaose

GalNAcα1-3GalNAcβ1-3Galα1-4Galβ1-4Glc C34H58N2O26 FW 910.82

Tumor associated antigen expressed in gastric cancer Hirayama R et al,. 1989. Cancer. Apr 15;63(8):1528-33 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY133 Forssman antigen triaose

GalNAcα1-3GalNAcβ1-3Gal C22H38N2O16 FW 586.54

Tumor associated antigen expressed in gastric cancer Hirayama R et al,. 1989. Cancer. Apr 15;63(8):1528-33 5 mg, 25 mg, 100 mg, 1 g, 5 g

OOH

NHAc

O

OH

OH

OH

OH

OO

OH

OH

OH

OOH

OH

O

HOHOO

HOO

OH

NHAc

OH

O

OOH

NHAc

OH

OO

OH

OH

OH

OH

HOO

OH

NHAc

OH

O



OOligoTech®® GGlycan ooligosaccharides Production by bacterial fermentation

Glucuronylated oligosaccharides

GLY180 Glucuronyl-lactose HNK 1 epitope precursor

Sodium salt

GlcAβ1-3Galβ1-4Glc C18H29O17Na

FW 540.00

precursor of the brain carbohydrate motif HNK-1, involved in neural cell adhesion Glycobiology, 18, n°2, pp. 152–157, 2008

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY181 Glucuronyl-LNT Glucuronyl-Lacto-N-tetraose

Sodium salt

GlcAβ1-3Galβ1-3GlcNAcβ1-3Galβ1-4Glc C32H52NO27 Na

FW 883.75

5 mg, 25 mg, 100 mg, 1 g, 5 g

O

OH

OH

OHOOH

OH

HOOHO

OO

HO

OH

OH

COOH

O

OH

OH

OHOOH

OH

HOO

OO

OH OHO

OH

NHAc

OHO

OH

OHO

OH

HO OHO

COOH



OOligoTech®®

Trehalose-like oligosaccharides


Miscellaneous

GLY160 Galactosyl-lactose

Galβ1-4Glcβ1-1βGal C18H32O16 FW 504.43

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY161 Difucosylpentaose

Fucα1-2Galβ1-4Glcβ1-1βGalα2-1Fuc C30H52O24

FW 796.71

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY162 Disialosylpentaose Sodium salt Neu5Acα2-3Galβ1-4Glcβ1-1βGalα2-3Neu5Ac C40H64N2O32Na2

FW 1130.90

5 mg, 25 mg, 100 mg, 1 g, 5 g

O

OHOO

OH

HO

OH

OH

HO

OH

O

HO

OH

OH

OH

O

O

OO

O

O

OH

HO

OH

OH

HO

OH

OHHO

OH

OHO

OH OH

O

O

OH

OH

OH

O

O

OHOO

OH OH

OH

HO

OH

O

HO

OHOH

OO

O

OHAcHN

HOOH

HO

HOOC

O

O

AcH

N OH

COOH

HO

OH

OH



OOligoTech®® Blood group-related oligosaccharides

Globo-Series analogues (Core structure type 1 & 2)

GLY163 2'2 DiFucosyllactose

Fucα1-2Galβ1-4(Fucα1-2)Glc C24H42O19

FW 634.57

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY164 Fucosylated A antigen type 5

GalNAcα1-3(Fucα1-2)Galβ1-4(Fucα1-2)Glc C32H55NO24

FW 837.77

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY165 Fucosylated B antigen type 5

Galα1-3(Fucα1-2)Galβ1-4(Fucα1-2)Glc C30H52O24

FW 796.71

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY190 Globotetraose analogue / Gb4 analogue

GlcNAcβ1-3Galα1-4Galβ1-4Glc C26H45NO21 FW 707.62

5 mg, 25 mg, 100 mg, 1 g, 5 g

OOH

NHAc

O

OH

OH

OH

HOO

OOH

OH

OH

OOH

OH

O

HOHO

O

HO

O

OO

O

O

OH

HO

OHOH

OH

HO

OH

OHHO

O

OHO

OH OH

O

OO

O

O

OH OHOH

OH

HO

OH

OHHO

OOH

AcHN

OH

O

HO O

OHO

OH OH

O

OO

O

O

OH

O

OHOH

OH

HO

OH

OHHO

OOH

OH

OH

HO O

OHO

OH OH



OOligoTech®®

GLY191-1 Globopentaose analogue type 1 Gb5 analogue type 1

Galβ1-3GlcNAcβ1-3Galα1-4Galβ1-4Glc C32H55NO26 FW 869.76

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY191-2 Globopentaose analogue type 2 Gb5 analogue type 2

Galβ1-4GlcNAcβ1-3Galα1-4Galβ1-4Glc C32H55NO26

FW 869.76

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY192 Globotetraose Lewisa analogue Gb4-Lewisa analogue

Galβ1-3(Fucα1-4)GlcNAcβ1-3Galα1-4Galβ1-4Glc C38H65NO30 FW 1015.90

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY193 Globotetraose Lewisx analogue Gb4-Lewisx analogue


5 mg, 25 mg, 100 mg, 1 g, 5 g

O

OH

OH

OH

OOH

OH

OH

OOH

OH

O

HOHO

O

AcNHO

OHO

O

OH

HO

OH

OH

HO O

OOH

NHAc

O

OH

OH

OH

OO

OH

OH

OH

OOH

OH

O

HOHO

O

O

OH

O

OH

HO

OH

O

O

OHOH

HO

O

OH

OH

OH

OOH

OH

OH

OOH

OH

O

HOHO

O

AcNHO

OHO

O

OH

HO

OH

OH

O

OHO

OHOH

O

OOH

NHAc

O

OH

OH

OH

HOO

OOH

OH

OH

OOH

OH

O

HOHO

O

O

OH

O

OH

HO

OH



OOligoTech®®

GLY194-1 Globo-H analogue type 1

Fucα1-2Galβ1-3GlcNAcβ1-3Galα1-4Galβ1-4Glc C38H65NO30 FW 1015.90

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY194-2 Globo-H analogue type 2


5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY195-1 SSEA-4 hexaose analogue type 1 Sodium salt

NeuAcα2-3Galβ1-3GlcNAcβ1-3Galα1-4Galβ1-4Glc C43H71N2O34Na FW 1183.00

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY195-2 SSEA-4 hexaose analogue type 2 Sodium salt


5 mg, 25 mg, 100 mg, 1 g, 5 g

O

OH

OH

OH

OOH

OH

OH

OOH

OH

O

HOHO

O

AcNHO

OO

OH

HO

OH

OH

HO O

O

OOH

OHOH

OOH

NHAc

O

OH

OH

OH

HOO

OOH

OH

OH

OOH

OH

O

HOHO

O

OO

OH

HO

OH

O

OOH

OHHO

O

OH

OH

OH

OOH

OH

OH

OOH

OH

O

HOHO

O

AcNHO

OO

OH OH

OH

HO O

OH

OO

OHAcHN

HOHO

HOOCOH

O

OH

NHAc

O

OH

OH

OH

HOO

OOH

OH

OH

OOH

OH

O

HOHO

O

OO

OH OH

OH

OO

OHAcHN

HOOH

HO

HOOC



OOligoTech®®

Isoglobo-Series analogues (Core structure type 1 & 2)

GLY196-1 Sialylated-SSEA-4 hexaose analogue type 1 Sodium salt

NeuAcα2-8NeuAcα2-3Galβ1-3GlcNAcβ1-3Galα1-4Galβ1-4Glc C54H87N3O42Na2

FW 1496.23

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY196-2 Sialylated-SSEA-4 hexaose analogue type 2 Sodium salt


FW 1496.23

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY197 Isoglobotetraose analogue / iGb4 analogue

GlcNAcβ1-3Galα1-3Galβ1-4Glc C26H45NO21 FW 707.62

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY198-1 Isoglobopentaose analogue type 1/ iGb5 analogue type 1

Galβ1-3GlcNAcβ1-3Galα1-3Galβ1-4Glc C32H55NO26 FW 869.76

5 mg, 25 mg, 100 mg, 1 g, 5 g

O

OH

OH

OH

OOH

OH

OH

OOH

OH

O

HOHO

O

AcNHO

OO

OH OH

OH

HO O

OH

OO

OHAcHN

HOHO

HOOCOO

OHAcHN

HOOH

HO

HOOC

OOH

NHAc

O

OH

OH

OH

HOO

OOH

OH

OH

OOH

OH

O

HOHO

O

O

O

OH OH

OH

OO

OHAcHN

HOHO

HOOCOO

OHAcHN

HOOH

HO

HOOC

O

OH

OH

OHOOH

OH

HOO

OOH

OH

OH

O

OHHOO

OH

NHAc

OHO

O

OH

OH

OHOOH

OH

HOO

OOH

OH

OH

O

OHO

O

OH OHO

OH

NHAc

OHO

OH

HO



OOligoTech®®

GLY198-2 Isoglobopentaose analogue type 2 / iGb5 analogue type 2

Galβ1-4GlcNAcβ1-3Galα1-3Galβ1-4Glc C32H55NO26

FW 869.76

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY199 Isoglobotetraose Lewisa analogue iGb4-Lewisa analogue


5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY200 Isoglobotetraose Lewisx analogue type 2 iGb4-Lewisx analogue type 2


5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY201-1 Isoglobo-H analogue type 1


5 mg, 25 mg, 100 mg, 1 g, 5 g

O

OH

OH

OHOOH

OH

HOO

OOH

OH

OH

O

OHNHAc

O

OHO

O

OH

HO

OH

OH

HO O

O

OH

OH

OHOOH

OH

HOO

OOH

OH

OH

O

OHNHAc

O

OHO

O

OH

HO

OH

OH

O

OHO

OHOH

O

O

OH

OH

OHOOH

OH

HOO

OOH

OH

OH

O

OHO

O

OH OHO

OH

NHAc

O

OH

HOO

O

OHOH

HO

O

OH

OH

OHOOH

OH

HOO

OOH

OH

OH

O

OHO

O

OH OHO

OH

NHAc

OHO

HO

O

OOH

OHHO



OOligoTech®®

GLY201-2 Isoglobo-H analogue type 2


5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY202-1 Sialylated isoglobopentaose analogue type 1 Sialylated iGb5 analogue type 1

Sodium salt


5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY202-2 Sialylated isoglobopentaose analogue type 2 Sialylated iGb5 analogue type 2

Sodium salt


5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY203-1 Disialylated isoglobopentaose analogue type 1 Disialylated iGb5 analogue type 1

Sodium salt


FW 1496.23

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY203-2 Disialylated isoglobopentaose analogue type 2 Disialylated iGb5 analogue type 2

Sodium salt


FW 1496.23

5 mg, 25 mg, 100 mg, 1 g, 5 g

O

OH

OH

OHOOH

OH

HOO

OOH

OH

OH

O

OHNHAc

O

OHO

O

OH OH

OH

HO OO

O

OHAcHN

HOOH

HO

HOOC

O

OH

OH

OHOOH

OH

HOO

OOH

OH

OH

O

OHO

OH

NHAc

HOO

OO

OH OH

OH

OO

OHAcHN

HOOH

HO

HOOC

O

OH

OH

OHOOH

OH

HOO

OOH

OH

OH

O

OHNHAc

O

OHO

O

OH OH

OH

HO OO

O

OHAcHN

HOHO

HOOCOO

OHAcHN

HOOH

HO

HOOC

O

OH

OH

OHOOH

OH

HOO

OOH

OH

OH

O

OHAcNH

O

OO

O

O

OH OH

OH

HO

OH

OHHO

OHO

O

OH

OH

OHOOH

OH

HOO

OOH

OH

OH

O

OHO

OH

NHAc

HOO

OO

OH OH

OH

OO

OHAcHN

HOHO

HOOCOO

OHAcHN

HOOH

HO

HOOC



OOligoTech®® Ganglio-Series analogues

GLY111 GM2 Ganglioside sugar analogue Sodium salt

Galβ1-4(Neu5Acα2-3)Galβ1-4Glc

C29H48NO24Na FW 817.67

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY173 GalNAc-aGM1 (GalNAc-asialo GM1) Ganglioside sugar GalNAcβ1-4Galβ1-3GalNAcβ1-4Galβ1-4Glc

C34H58N2O26 FW 910.82

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY174 GalGalNac-aGM1 (GalGalNAc asialo GM1) Ganglioside sugar Galβ1-3GalNAcβ1-4Galβ1-3GalNAcβ1-4Galβ1-4Glc C40H68N2O31

FW 1072.95

5 mg, 25 mg, 100 mg, 1 g, 5 g

OH

O

OH OH

O

O

OHOH

OHOH

OHO OH

O

O

O

OHAcHN

HOHO

HOOCOH

HO

O

OH

OH

OHHOOOH

OHO

NHAc

OOH

OOH

OOH

HO O

HOOH

OOH

NHAcO

OH

HO

O

OH

OH

OHHOOOH

OHO

NHAc

OOH

OOH

OOH

HO O

HOOH

OOH

NHAcO

OOH

OH

OHOH

HO O



OOligoTech®®


Monosaccharides, Di-, Tri-, Tetrasaccharides




Monosaccharides

GLY140 Sialic acid (N-acetylneuraminic acid) Sodium salt

NeuAc C11H18NO9Na FW 331.26 [131-48-6]

1 g, 5 g

GLY141 N-acetylgalactosamine

GalNAc C8H15NO6 FW 221.21 [1811-31-0]

1 g, 5 g

GLY142 N-acetylmannosamine

ManNAc C8H15NO6 FW 221.21 [3615-17-6]

1 g, 5 g

GLY143 L-fucose

Fuc C6H12O5 FW 164.15 [2438-80-4]

1 g, 5 g

OHO

OHAcHN

HOOH

HO

HOOC

O

OH

NHAc

OH

OHHO

O

NHAc

OHHOHO

HO

OH

OOH

OHHO




Di-Tri-Tetrasaccharides

Disaccharides

GLY151 GalNAcβ1-3Gal / Gb4 Globoside terminal

“Common oligosaccharide moieties inhibit the adherence of typical and atypical respiratory pathogens” R. Thomas and T. Brooks, Journal of Medical Microbiology (2004), 53, 833–840

C14H25NO11

FW 383.35

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY153 α1-3 galactobiose Galα1-3Gal

C12H22O11 FW 342.29

[13168-24-6]

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY154 α1-4 galactobiose Galα1-4Gal/ Galabiose

C12H22O11 FW 342.29

[80446-85-1]

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY155 GlcNAcβ1-3Gal C14H25NO11

FW 383.35

5 mg, 25 mg, 100 mg, 1 g, 5 g

HOO

OH

NHAc

OH

OO

OH

OH

OH

OH

O

OH

OH OH

OH

OOH

OH

OH

O

HO

O

OH

OH

OH

OOH

OH

O

HO OH

HO

HOO

OH

NHAc

HOO

OOH

OH

OH

OH



OOligoTech®®

Trisaccharides

Tetrasaccharides

GLY156 N,N’-diacetylchitobiose Chitinbiose)

GlcNAcβ1-4GlcNAc C16H28N2O11 FW 424.40

[35061-50-8]

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY157 3 Sialylgalactose Sodium salt Neu5Acα2-3Gal

C17H28NO14Na FW 493.40

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY158 Galα1-4Galα1-4Gal Galα1-4Galα1-4Gal C18H32O16

FW 504.43

5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY159 Galα1-4Galα1-4Galα1-4Gal Galα1-4Galα1-4Galα1-4Gal C24H42O21

FW 666.57

5 mg, 25 mg, 100 mg, 1 g, 5 g

OOH

OH

OH

OOH

OH

O

HO

HO

OOH

OH

O

HO

OOH

OH

O

HO OH

O

OH

OH

OH

O

OH

O

OHAcHN

HOOH

HO

HOOC

HO

OOH

AcNH

HOO

OOH

OHHO

AcNH

OOH

OH

OH

OOH

OH

O

HO

HO

OOH

OH

HO OH

O



OOligoTech®®


GlycoBricks® Functionalized Glycans



OOligoTech®® GGlycoBBrricks®® FFunctionalized GGlycans

About GlycoBricks® GlycoBricks® are functionalized oligosaccharides derived from bioactive oligosaccharides

A choice of different types of activated groups is proposed at the reducing end of the

Glycobricks®:

Any customized Glycobricks® request is evaluated covering all oligosaccharides disclosed in

this catalogue and beyond on demand. The products are available from the mg to the multi-gram scale.

They are produced through manufacturable process to anticipate potential industrial

application

GlycoBricks® Applications

Affinity adsorbents

Click chemistry

Labeledoligosaccharides

• Beads / Resins• Purification / removal of antibodies,viruses, toxins, lectins• Immunology studies

• Building of macromolecular architectures(glycoclusters, dendrimers...)• Ready for glycan array immobilization

• Fluorescent probes or biotin• Imaging, analysis of interactions,analysis by HPLC, targeting

GlycoBrick®

Spacer+Propargyl AminoPropyl

Spacer is to be defined following the request and can be an O, an N-Acetyl, or an aliphatic group



OOligoTech®® GGlycoBBrricks®® FFunctionalized GGlycans

Each glycan or natural oligosaccharide structures proposed in this catalogue can be potentially functionalized by Aminopropyl and / or Propargyl reactive groups.

The following items are examples of glycobricks already made and available on the shelf.

GLY034-AP

Blood group A antigen triaose-β-Aminopropyl

GalNAcα1-3(Fucα1-2)Galβ-O-(CH2)3-NH2

C23H42N2O15 FW 586.58

NEW 1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY036-1-PR

Blood group A antigen pentaose type 1-β-Propargyl

GalNAcα1-3(Fucα1-2)Galβ1-3GlcNAcβ1-3Galβ-O-CH2-C CH

C37H60N2O25 FW 932.86

NEW 1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY037-1-NPR

Blood group A antigen hexaose type 1-β-N-Acetyl Propargyl

GalNAcα1-3(Fucα1-2)Galβ1-3GlcNAcβ1-3Galβ1-4Glcβ-NAc-CH2-C CH

C45H73N3O30

FW 1136.06

NEW 1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g

O

O

O

OH OH

OH

OHHO

OOH

AcHN

OH

O O

HO

NH2

OOH

OH

O

OO

OH OHO

OH

NHAc

OHO

O

OOH

OHHO

O

AcHN

OHOH

O

HO OH

O

OH

OH

NOOH

OH

HOO

OO

OH OHO

OH

NHAc

OHO

O

OOH

OHHO

OOH

AcHN

OH

O

HO OH

Ac



OOligoTech®®

GLY058-AP Blood group B antigen triaose-β-Aminopropyl Galα1-3(Fucα1-2)Galβ-O-(CH2)3-NH2

C21H39NO15 FW 545.53

NEW 1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY040-1-NPR

Blood group B antigen hexaose type 1-β-N-Acetyl Propargyl

Galα1-3(Fucα1-2)Galβ1-3GlcNAcβ1-3Galβ1-4Glcβ-NAc-CH2-C CH C43H70N2O30

FW 1095.00

NEW 1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY050-PR LewisX tetraose-β-Propargyl Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ-O-CH2-C CH

C29H47NO20 FW 729.67

NEW 1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY053-PR Sialyl LewisX pentaose-β-Propargyl Sodium salt

Neu5Acα2-3Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ-O-CH2-C CH C40H63N2O28Na FW 1042.91

NEW 1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g

O

O

O

OH OH

OH

OHHO

O

OH

OHOH

O O

HO

NH2

AcNHO

OHO

O

OH

HO

OH

OH

O

OH

OH

O

OH

O

OHO

OHOH

O

O

OH

OH

NOOH

OH

HOO

OO

OH OHO

OH

NHAc

OHO

O

OOH

OHHO

O

OH

OHOH

O

HO OH

Ac

AcNHO

OHO

O

OH OH

OH

O

OH

OH

O

OH

O

OHO

OHOH

OO

O

OHAcHN

HOOH

HO

HOOC



OOligoTech®®

GLY056-NPR

Lewisb pentaose-β-N-Acetyl Propargyl

Fucα1-2Galβ1-3(Fucα1-4)GlcNAcβ1-3Galβ-NAc-CH2-C CH

C37H60N2O24 FW 913.87

NEW 1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY090-AP 3'Sialyllactose-β-Aminopropyl GM3 Ganglioside sugar-β-Aminopropyl

Sodium salt

Neu5Acα2-3Galβ1-4Glcβ-O-(CH2)3-NH2

C26H45N2O19Na

FW 712.62

NEW 1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY090-NPR

3'Sialyllactose-β-N-Acetyl Propargyl GM3 Ganglioside sugar-β-N-Acetyl Propargyl

Sodium salt

Neu5Acα2-3Galβ1-4Glcβ-NAc-CH2-C CH

C28H43N2O19Na

FW 734.63

NEW 1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY094-NPR

GD2 Ganglioside sugar-β-N-Acetyl Propargyl Sodium salt

GalNAcβ1-4(Neu5Acα2-8Neu5Acα2-3)Galβ1-4Glcβ-NAc-CH2-C CH

C47H72N4O32Na2 FW 1251.05

NEW 1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g

OOH

OH

OO

OH OHO

OH

NHAc

O

OH

NHO

O

OH OH

HO

O

OOH

OHHO

OAc

OO

OHAcHN

HO

OH

HO

HOOC

O

OO

OH OHOH

OH

HO

OH

O NH2

OO

OHAcHN

HO

OH

HO

HOOC

O

OO

OH OHOH

OH

HO

OH

N

Ac

O

OH

OH

HOOOH

OHO

NHAc

OOH

HO

OHO

OO

OHAcHN

HO

HO

HOOCOO

OHAcHN

HOOH

HO

HOOC

N

Ac



OOligoTech®®

GLY096-AP GM1a Ganglioside sugar-β-Aminopropyl Sodium salt

Galβ1-3GalNAcβ1-4(Neu5Acα2-3)Galβ1-4Glcβ-O-(CH2)3-NH2

C40H68N3O29 Na FW 1077.95

NEW 1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY096-NPR

GM1a Ganglioside sugar-β-N-Acetyl Propargyl Sodium salt

Galβ1-3GalNAcβ1-4(Neu5Acα2-3)Galβ1-4Glcβ-NAc-CH2-C CH

C42H66N3O29Na FW 1099.96

NEW 1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY098-NPR

GD1a Ganglioside sugar-β-N-Acetyl Propargyl Sodium salt

Neu5Acα2-3Galβ1-3GalNAcβ1-4(Neu5Acα2-3)Galβ1-4Glcβ-NAc-CH2-C CH C53H82N4O37Na2

FW 1413.19

NEW 1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g

O

OH

OH

HOO

OH

OHO

NHAc

OOH OHO

OO

OH

AcHN

HO

HO

HOOCOH

O

OH

OH

HO

OHO

O NH2

O

OH

OH

HOO

OH

OHO

NHAc

OOH OHO

OO

OH

AcHN

HO

HO

HOOCOH

O

OH

OH

HO

OHO

N

Ac

O

OH

OH

NHOOOH

O

NHAc

OOH

OH

OOH

O

O

O

OHAcHN

HOHO

HOOCOH

OO

OHAcHN

HOHO

HOOCOH

O

OH

OHOH

Ac



OOligoTech®®

GLY120-NPR

Globotriaose /Gb3-β-N-Acetyl Propargyl Pk antigen-β-N-Acetyl Propargyl

Galα1-4Galβ1-4Glcβ-NAc-CH2-C CH

C23H37NO16 FW 588.53

NEW 1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY123-NPR

Globo-H-β-N-Acetyl Propargyl SSEA-3b-β-N-Acetyl Propargyl

Fucα1-2Galβ1-3GalNAcβ1-3Galα1-4Galβ1-4Glcβ-NAc-CH2-C CH

C43H70N2O30

FW 1095.00

NEW 1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY220-NPR Lactose-β-N-Acetyl Propargyl Galβ1-4Glcβ-NAc-CH2-C CH

C17H27NO11 FW 421.39

NEW 1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY221-AP Galactose-β-Aminopropyl Galβ-O-(CH2)3-NH2

C9H19N1O6 FW 237.25

NEW 1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g

GLY221-PR Galactose-β-Propargyl Galβ-O-CH2-C CH

C9H14O6 FW 218.20

NEW 1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g

O

OH

OH

N

OOH

OH

OH

OOH

OH

O

HOHO

O

HO

Ac

O

O

O

O

OH

HO

OH

OH

OHHO

OOH

NHAc

O

OH

OH

N

OH

OO

OH

OH

OH

HOO

OH

OH

O

HOO

Ac

OOH

OH

O

OH

HO NH2

O

OH

OH

NOOH

OH

HOO

OH

AcHO

OOH

OH

O

OH

HO



OOligoTech®®

Other functionalized Mono-Disaccharides available upon request

Available prepacks on request

Product code

Product name Structure Text formula

GLY141-PR N-acetylgalactosamine-α-propargyl

(Tn antigen analogue-α-propargyl)

GalNAc-α-O-CH CH

GLY141-Ab N-acetylgalactosamine-β-aminooxy

(Tn antigen analogue-β-aminooxy)

N-GlcNAc-β-O-NH2

GLY141-Aa N-acetylgalactosamine-α-aminooxy

N-GlcNAc-α-O-NH2

GLY143-Ab L-Fucose-β-aminooxy

Fuc-β-O-NH2

GLY143-Aa L-Fucose-α-aminooxy

Fuc-α-O-NH2

GLY143-PR L-Fucose-α-propargyl

L-Fuc-α-O-CH CH

GLY220-PR Lactose-β-propargyl

Galβ1-4Glc-β-O-CH CH

GLY220-Aa Lactose-β-aminooxy

Galβ1-4Glc-β-O-NH2

GLY221-Ab Galactose-β-aminooxy

Gal-β-O-NH2

GLY222-Ab Glucose-β-aminooxy

Glc-β-O-NH2

GLY222-PR Glucose-β-propargyl

Glc-β-O-CH CH



OOligoTech®®

Other functionalized Mono-Disaccharides available upon request

Available prepacks on request

Product code

Product name Structure Text formula

GLY223-AM Mannose-α-aminooxy

Man-α-O-NH2

GLY223-PR Mannose-α-propargyl

Man-α-O-CH CH

GLY224-PR N-acetylglucosamine-β-propargyl

GlcNAc-β-O-CH CH

GLY224-Ab N-acetylglucosamine-β-aminooxy

GlcNAc-β-O-NH2

GLY224-Aa N-acetylglucosamine-α-aminooxy

GlcNAc-α-O-NH2

GLY225-PR Galβ1-3Gal-α-propargyl

(TF antigen analogue-α-propargyl)

Galβ1-3Gal-α-O-CH CH

GLY225-Aa Galβ1-3Gal-α-aminooxy

(TF antigen analogue-α-aminooxy)

Galβ1-3Gal-α-O-NH2



OOligoTech®®

Glycosaminoglycans



OOligoTech®®

Heparosan from E. coli K12 Strain

Heparosan-derived oligosaccharides

GGlycosaminoglycans Production by bacterial fermentation Heparosan & derived oligosaccharides

GAG070 Heparosan K5 polysaccharide Sodium salt Polysaccharide produced by fermentation in engineered E coli K-12 Strain

Average MW: 105 kDa (~DP500) Osamine/ uronic acids ratio: ~ 1

NEW 100 mg, 1 g, 10 g

GAG071 Heparosan-derived oligosaccharide DP2 Sodium salt ΔGlcAβ(1-4)GlcNAc

C14H20NO11 FW 401.30

NEW 5 mg, 25 mg

O

-OOC

HO

OH

OHO

O

HO

OH

NHAcO

-OOC

O

OH

OHO

O

HO

OH

NHAcOH

n

O

-OOC

OH

OHO

O

HO

OH

NHAcOH


Heparosan is a bacterial glycosaminoglycan composed of regular repeats of 4-β-glucuronyl-(1 4)-α-N-acetylglucosaminyl-1 produced and found in the capsule of some pathogenic bacteria such as Escherichia coli K5 and Pasteurella multocida. The heparosan skeleton is a precursor of heparin synthesis, and bacterial heparosan itself can serve as a precursor for the synthesis of non-animal sourced heparin-like products.


Heparosan-derived oligosaccharides are produced by bacterial fermentation in engineered bacteria by Lyase degrading enzyme expression. We offer a range of oligosaccharides from Dp 2 to Dp 10 (degree of polymerization).

General Formula : ΔGlcAβ(1-4)[GlcNAcα(1-4)GlcAβ(1-4)]nGlcNAc Glucuronic acid GlcA is unsaturated at the non-reducing end of the oligosaccharides due to Lyase activity. The C4-C5 double bond absorbs strongly at 232 nm and can be used for monitoring the oligosaccharides in various separation system.



OOligoTech®®

GAG072 Heparosan-derived oligosaccharide DP4 Sodium salt ΔGlcAβ(1-4)GlcNAcα(1-4)GlcAβ(1-4)GlcNAc

C28H40N2O22Na2 FW 802.59

NEW 5 mg, 25 mg

GAG073 Heparosan-derived oligosaccharide DP6 Sodium salt ΔGlcAβ(1-4)[GlcNAcα(1-4)GlcAβ(1-4)]2GlcNAc

C42H60N3O33Na3 FW 1203.89

NEW 5 mg, 25 mg


C56H80N4O44Na4 FW 1605.18

NEW 5 mg, 25 mg


C70H100N5O55Na5 FW 2006.48

NEW 5 mg, 25 mg

O

-OOC

OH

OHO

O

HO

OH

NHAcO

-OOC

O

OH

OHO

O

HO

OH

NHAc

OH

O

-OOC

OH

OHO

O

HO

OH

NHAcO

-OOC

O

OH

OHO

O

HO

OH

NHAc

OH

2

O

-OOC

OH

OHO

O

HO

OH

NHAcO

-OOC

O

OH

OHO

O

HO

OH

NHAc

OH

3

O

-OOC

OH

OHO

O

HO

OH

NHAcO

-OOC

O

OH

OHO

O

HO

OH

NHAc

OH

4


5


OOligoTech®®

Aminoglycoside derivatives



OOligoTech®®

AAminoglycoside derivatives

AMG001 Aminoglycoside platform 1

5

O

O

R1O

NHTr

R1O

TrHNO

OR1

NHTr

TrHN

R2

R1=H R2=H

R1=PMB* with: R2=(CH2)6Br or

(CH2)6N3 or (CH2)6NH2 or (CH2)6NHC(O)(CH2)2COOH

*PMB=para-methoxybenzyl, Tr=Trityl 5 mg, 25 mg, 100 mg, 1 g, 5 g


5

O

O

HO

NH2

HO

H2NO

OH

NH2

H2N

R2

R2=H: neamine

R2=(CH2)nBr or (CH2)nN3 or (CH2)nNH2 or (CH2)6NHC(O)(CH2)2COOH or (CH2)n-CH3

(n≥ 6)

5 mg, 25 mg, 100 mg, 1 g, 5 g


4'

O

O

O

NHTr

R1O

TrHNHO

OR1

NHTr

TrHN

R2

R1=PMB with: R2=H or

(CH2)nBr or (CH2)nN3 or (CH2)nNH2 or

(CH2)nNHC(O)(CH2)2COOH (n≥ 6)

*PMB=para-methoxybenzyl, Tr=Trityl 5 mg, 25 mg, 100 mg, 1 g, 5 g


4'

O

O

O

NH2

HO

H2NHO

OH

NH2

H2N

R2

R2=(CH2)nBr or (CH2)nN3 or (CH2)nNH2 or

(CH2)nNHC(O)(CH2)2COOH or (CH2)n-CH3

(n≥ 4)

5 mg, 25 mg, 100 mg, 1 g, 5 g

Beyond antibacterial applications, aminoglycoside derivatives are of large interest as a source of new molecules for the research community for example for dynamic combinatorial chemistry. Indeed, these compounds can receive many applications (such as potential antiviral agents, transfection agents or agents useful in chiral-exchange chromatography).



OOligoTech®®


Human & Bacterial Lectins



OOligoTech®® HHuman & Bacterial LLectins Production by bacterial fermentation

Our Lectin offer

Lectin Uses and Applications

Produced by bacterial fermentation

Ensuring repeatability and reliability of production and structure. heavy metals free, no glycosylated lectins.

This process allows any scale-up demand fitting your need.

High affinity for ligands

Very low Kd from micromolar range giving a better sensitivity to the ligand.

Fully Characterized, QA/QC policies

Monitoring by ITC (isothermal titration calorimetry) ensuring reliability of calculated Kd for a given lectin, affinity checking.

Tested on microarray developped by CFG (Consortium for Functional Glycomics). Product information is also available from CFG web Site.

http://www.functionalglycomics.org/static/consortium/resources.shtml

Crystal structure is available for each lectin.

Calcium dependent (from 5 out of 6 proposed lectins)

Calcium is required for the carbohydrate attachment which is an Asset for using these items as biotechnology tools for affinity chromatography.

Available with biotine or fluorophore labels on demand (FITC, Cy…)

No alterations of binding properties despite presence of labeling.

Biomedical research

Carbohydrate recognition studies

Biochemical tools (glycoproteins purification, …)



OOligoTech®® LEC101 LecB (PA-IIL) from Pseudomonas aeruginosa Pack size

Molecular weight 12.75 kDa (monomer)

1, 5, 10 mg

Oligomerization Tetramer Appearance Lyophilized Sugar specificity Fucose Sugar affinity Kd for αMeFuc : 0.41 μM Other known specificity Lewisa > αMeFuc > Fuc> Man Properties Calcium dependent Caution Standard conditions of use

LEC102 LecA (PA-IL) from Pseudomonas aeruginosa Pack size


1, 5, 10 mg

Oligomerization Tetramer Appearance Lyophilized Sugar specificity αGalactose Sugar affinity Kd for αMeGal: 50 μM Other known specificity αGal disaccharides > αMeGal > βMelGal Properties Calcium dependent Caution Cytotoxic/requires trained and qualified personnel

LEC202 RSL from Ralstonia solanacearum Pack size

Molecular weight 9.9 kDa (monomer) Oligomerization Trimer (with 6 fucose binding sites)

Appearance Lyophilized Sugar specificity Fucose Sugar affinity Kd for aMeFuc: 0.74 μM Other known specificity αFuc1-2Gal > αFuc1-6GlcNAC > αFuc1-4GlcNAC… Properties - Caution Standard conditions of use

1, 5, 10 mg

LEC301 BC2LA from Burkholderia cenocepacia Pack size


Oligomerization Dimer Appearance Lyophilized Sugar specificity Mannose Sugar affinity Kd for aMeMan: 2.75 μM Other known specificity All αMan- terminating oligosaccharides Properties Calcium dependent Caution Standard conditions of use

1, 5, 10 mg



OOligoTech®®

LEC302 BC2LC-Nt from Burkholderia cenocepacia Pack size


Oligomerization Trimer Appearance Solution in Tris buffer Sugar specificity Fucose Sugar affinity Kd for Lewisy: 2.4 μM Kd for Fuc: 2.7 mM

Other known specificity Lewisy > H type 1 > Lewisa > ...> Fuc Properties - Caution Standard conditions of use

1 mg/mL

LEC401 DC-SIGN ECD (extra-cellular domain) Pack size

Human protein produced in E.coli


Oligomerization Tetramer

Appearance Solution in 150 mM NaCl, 25 mM Tris pH 8,4 mM CaCl2 buffer

Sugar specificity High Mannose

Known interaction Various pathogen surface glycoconjugates (HIV, HCV, CMV, Ebola, Dengue, M. tuberculosis...)

Other known specificity Fucose, Lewisx , Lewisy Properties Calcium dependent Caution Standard conditions of use

0.2 mg, 1 mg

LEC402 Langerin ECD (extra-cellular domain) Pack size

Human protein produced in E.coli


Oligomerization Trimer

Appearance Solution in 150 mM NaCl, 25 mM Tris pH 8,4 mM CaCl2 buffer

Sugar specificity High Mannose Known interaction gp120 (HIV), Keratan sulfate Other known specificity Sulfated sugars (Sulfated Le x

Properties Calcium dependent Caution Standard conditions of use

0.2 mg, 1 mg

M Tris pH 8,4 mM

conjugates,

H 8,4 mM

)

Catalogue OligoTech 2012 p160.pdf 1 13/06/12 14:05:45

wis , sulfated galactose


OOligoTech®®

Index Product code & Product name



OOligoTech®® PProduct code index

A

ALG100 · 71 ALG101 · 71 ALG102 · 71 ALG103 · 71 ALG104 · 71 ALG105 · 71 ALG300 · 72 ALG310 · 72 ALG320 · 72 ALG330 · 72 ALG500 · 73 ALG510 · 73 ALG520 · 73 ALG530 · 73 AMG001 · 156 AMG002 · 156 AMG003 · 156 AMG004 · 156 ARB105 · 80

F

FRU100 · 83 FRU101 · 83 FRU102 · 83 FRU110 · 83 FRU111 · 83 FRU112 · 84 FRU113 · 84 FRU114 · 84 FRU115 · 84 FRU116 · 84 FRU117 · 84 FRU118 · 84 FRU130 · 84 FUC100 · 47 FUC110 · 48 FUC200 · 47 FUC210 · 48 FUC300 · 47 FUC310 · 48 FUC400 · 47 FUC410 · 48 FUC500 · 47 FUC510 · 48 FUC600 · 47

G

GAG070 · 152 GAG071 · 152

GAG072 · 153 GAG073 · 153 GAG074 · 153 GAL100 · 55 GAL101 · 55 GAL110 · 55 GAL111 · 55 GAL112 · 55 GAL200 · 57 GAL300 · 57 GAL400 · 57 GAL500 · 58 GAT100 · 77 GAT101 · 77 GAT102 · 77 GAT103 · 77 GAT110 · 78 GAT111 · 78 GAT112 · 78 GAT200 · 78 GAT300 · 78 GLU1000 · 15 GLU1100 · 18 GLU1101 · 18 GLU1110 · 15 GLU1111 · 15 GLU1112 · 16 GLU1120 · 18 GLU1121 · 18 GLU1122 · 18 GLU1131 · 19 GLU1140 · 19 GLU1141 · 19 GLU1142 · 19 GLU1150 · 19 GLU1151 · 19 GLU1152 · 19 GLU1160 · 16 GLU1161 · 16 GLU1162 · 17 GLU1170 · 19 GLU1171 · 19 GLU1180 · 17 GLU1181 · 17 GLU1182 · 18 GLU200 · 34 GLU300 · 21 GLU301 · 21 GLU302 · 21 GLU303 · 21 GLU304 · 22 GLU305 · 22 GLU306 · 22 GLU308 · 22 GLU309 · 22 GLU311 · 23

GLU312 · 23 GLU313 · 23 GLU314 · 23 GLU315 · 24 GLU316 · 24 GLU317 · 24 GLU318 · 24 GLU319 · 25 GLU320 · 25 GLU322 · 25 GLU330 · 25 GLU340 · 38 GLU410 · 37 GLU411 · 37 GLU420 · 39 GLU421 · 39 GLU422 · 39 GLU423 · 39 GLU424 · 39 GLU425 · 39 GLU426 · 39 GLU432 · 37 GLU433 · 37 GLU434 · 37 GLU435 · 38 GLU436 · 38 GLU437 · 38 GLU500 · 27 GLU501 · 27 GLU510 · 27 GLU600 · 29 GLU601 · 29 GLU602 · 29 GLU610 · 29 GLU611 · 29 GLU700 · 30 GLU800 · 31 GLU900 · 32 GLU910 · 32 GLY005 · 93 GLY006 · 94 GLY008 · 94 GLY009 · 93 GLY010 · 93 GLY011 · 94 GLY021 · 95 GLY022 · 95 GLY023 · 95 GLY030 · 97 GLY031-1 · 97 GLY031-2 · 97 GLY031-3 · 97 GLY032-1 · 98 GLY032-2 · 98 GLY033-1 · 98



OOligoTech®® GLY033-2 · 99 GLY034 · 99 GLY034-AP · 143 GLY035-1 · 99 GLY035-2 · 99 GLY035-3 · 100 GLY035-4 · 100 GLY035-5 · 100 GLY036-1 · 100 GLY036-1-PR · 143 GLY036-2 · 101 GLY037-1 · 101 GLY037-1-NPR · 143 GLY037-2 · 101 GLY038-1 · 102 GLY038-2 · 102 GLY038-3 · 102 GLY038-4 · 102 GLY038-5 · 103 GLY039-1 · 103 GLY039-2 · 103 GLY040-1 · 104 GLY040-1-NPR · 144 GLY040-2 · 104 GLY044 · 108 GLY045 · 107 GLY046 · 106 GLY047 · 107 GLY048 · 106 GLY049 · 105 GLY050 · 105 GLY050-PR · 144 GLY051 · 105 GLY052 · 106 GLY053 · 108 GLY053-PR · 144 GLY054 · 106 GLY055 · 107 GLY056 · 107 GLY056-NPR · 145 GLY058-AP · 144 GLY060 · 109 GLY061 · 110 GLY062 · 110 GLY063 · 109 GLY064 · 110 GLY065 · 111 GLY066 · 109 GLY067 · 111 GLY068 · 111 GLY070 · 114 GLY071 · 112 GLY072 · 114 GLY073 · 114 GLY074-1 · 112 GLY074-2 · 112 GLY075 · 113 GLY076 · 113 GLY077 · 113 GLY078 · 113

GLY079 · 113 GLY080 · 115 GLY081 · 116 GLY082 · 116 GLY083 · 117 GLY084-1 · 115 GLY084-2 · 116 GLY085-1 · 115 GLY085-2 · 117 GLY086-1 · 115 GLY086-2 · 117 GLY090 · 119 GLY090-AP · 145 GLY090-NPR · 145 GLY091 · 119 GLY092 · 119 GLY093 · 120 GLY094 · 120 GLY094-NPR · 145 GLY095 · 120 GLY096 · 120 GLY096-AP · 146 GLY096-NPR · 146 GLY097 · 121 GLY098 · 121 GLY098-NPR · 146 GLY099 · 121 GLY100 · 121 GLY101 · 122 GLY102 · 122 GLY103 · 122 GLY104 · 122 GLY105 · 119 GLY111 · 136 GLY120 · 124 GLY120-NPR · 147 GLY121 · 124 GLY122 · 126 GLY123 · 126 GLY123-NPR · 147 GLY124 · 125 GLY125 · 125 GLY126 · 94 GLY127 · 98, 125 GLY128 · 101 GLY129 · 104 GLY130 · 126 GLY131 · 126 GLY132 · 127 GLY133 · 127 GLY134 · 114 GLY135 · 124 GLY136 · 124 GLY140 · 138 GLY141 · 138 GLY141-Aa · 148 GLY141-Ab · 148 GLY141-PR · 148 GLY142 · 138 GLY143 · 138

GLY143-Aa · 148 GLY143-Ab · 148 GLY143-PR · 148 GLY151 · 139 GLY153 · 139 GLY154 · 139 GLY155 · 139 GLY156 · 140 GLY157 · 140 GLY158 · 140 GLY159 · 140 GLY160 · 129 GLY161 · 129 GLY162 · 129 GLY163 · 130 GLY164 · 130 GLY165 · 130 GLY171 · 125 GLY172 · 116 GLY173 · 136 GLY174 · 136 GLY180 · 128 GLY181 · 128 GLY190 · 130 GLY191-1 · 131 GLY191-2 · 131 GLY192 · 131 GLY193 · 131 GLY194-1 · 132 GLY194-2 · 132 GLY195-1 · 132 GLY195-2 · 132 GLY196-1 · 133 GLY196-2 · 133 GLY197 · 133 GLY198-1 · 133 GLY198-2 · 134 GLY199 · 134 GLY200 · 134 GLY201-1 · 134 GLY201-2 · 135 GLY202-1 · 135 GLY202-2 · 135 GLY203-1 · 135 GLY203-2 · 135 GLY220-NPR · 147 GLY220-PR · 148 GLY221-Ab · 148 GLY221-AP · 147 GLY221-PR · 147 GLY222-Ab · 148 GLY222-PR · 148 GLY223-AM · 149 GLY223-PR · 149 GLY224-Aa · 149 GLY224-Ab · 149 GLY224-PR · 149 GLY225-Aa · 149 GLY225-PR · 149



OOligoTech®® H

HGL100 · 88 HGL101 · 88

L

LEC101 · 159 LEC102 · 159 LEC202 · 159 LEC301 · 159 LEC302 · 160

LEC402 · 160

M

MAN100 · 62 MAN200 · 64 MAN201 · 64 MAN202 · 64

MAN213 · 64 MAN215 · 64 MAN219 · 64 MAN300 · 65 MAN400 · 65 MAN500 · 65 MAN600 · 67 MAN610 · 67 MAN700 · 68 MAN800 · 61 MAN801 · 61 MAN810 · 61

S

SPR100 · 86

U

ULV001 · 44 ULV002 · 44

ULV003 · 44 ULV005 · 44 ULV006 · 44 ULV007 · 44 ULV010 · 43 ULV011 · 44 ULV100 · 43 ULV101 · 43 ULV102 · 43 ULV103 · 43

X

XYL100 · 51 XYL101 · 51 XYL110 · 51 XYL111 · 51


LEC401 · 160

www.elicityl-oligotech.com Contact us for bulk quantities - [email protected] - +33 (0) 4 76 40 71 61

OOligoTech®® Product name index A-B

1-F-(1-β-fructofuranosyl)-2-nystose .....................................................................................84 1-F-(1-β-fructofuranosyl)-3-nystose .....................................................................................84 1-kestose (DP3) .................................................................................................................83 2’FL ..................................................................................................................................97 2’Fucosyllactose .................................................................................................................97 2'2 DiFucosyllactose ......................................................................................................... 130 3 Fucosyllactose ............................................................................................................... 109 3 Sialylgalactose .............................................................................................................. 140 3’Sialyl-3Fucosyllactose ..................................................................................................... 109 3’-α-sialyl-N-Acetyl-Lactosamine ........................................................................................ 116 3-FL................................................................................................................................ 109 3-Fucosylated Blood group A tetraose ................................................................................. 111 3-Fucosylated Blood group B tetraose ................................................................................. 111 3Sialyl-Gb3...................................................................................................................... 125 3'Sialyllactose .................................................................................................................. 119 3'Sialyllactose-β-Aminopropyl ............................................................................................ 145 3'Sialyllactose-β-N-Acetyl Propargyl .................................................................................... 145 Acemannan polysaccharide (Aloe vera) .................................................................................61 Acetylated XFG xyloglucan oligosaccharide (DP7) ...................................................................16 Acetylated XLFG xyloglucan oligosaccharide (DP10) ................................................................17 Acetylated XLG oligosaccharide ............................................................................................18 Acetylated XLLFG xyloglucan oligosaccharide (DP13) ..............................................................18 Acetylated XLLG oligosaccharide...........................................................................................19 Acetylated XXFG oligosaccharide ..........................................................................................19 Acetylated XXLG oligosaccharide (XXLG(Ac)) .........................................................................18 Agar polysaccharides ..........................................................................................................58 aGM1 (asialo GM1) Ganglioside sugar ................................................................................. 122 aGM2 (asialo GM2) Ganglioside sugar ................................................................................. 122 Alginate polysaccharides (from Ascophyllum nodosum) ...........................................................71 Alginate polysaccharides (from Chorda filum) ........................................................................71 Alginate polysaccharides (from Durvillaea antarctica) ..............................................................71 Alginate polysaccharides (from Fucus vesiculosus)..................................................................71 Alginate polysaccharides (from Laminaria) .............................................................................71 Alginate polysaccharides Kit .................................................................................................71 Aminoglycoside platform 1 ................................................................................................ 156 Aminoglycoside platform 2 ................................................................................................ 156 Aminoglycoside platform 3 ................................................................................................ 156 Aminoglycoside platform 4 ................................................................................................ 156 Apiogalacturonan polysaccharide (sodium salt) ......................................................................78 Arabinan polysaccharides from Apple ....................................................................................80 BC2LA from Burkholderia cenocepacia ................................................................................. 159 BC2LC-Nt from Burkholderia cenocepacia ............................................................................ 160 Blood group A antigen hexaose type 1 ................................................................................ 101 Blood group A antigen hexaose type 1-β-N-Acetyl Propargyl .................................................. 143 Blood group A antigen hexaose type 2 ................................................................................ 101 Blood group A antigen pentaose type 1 ............................................................................... 100 Blood group A antigen pentaose type 1-β-Propargyl.............................................................. 143 Blood group A antigen pentaose type 2 ............................................................................... 101 Blood group A antigen pentaose type 4 ............................................................................... 101 Blood group A antigen tetraose type 1 ..................................................................................99 Blood group A antigen tetraose type 2 ..................................................................................99 Blood group A antigen tetraose type 5 ................................................................................ 100 Blood group A antigen triaose ..............................................................................................99

165



OOligoTech®® Product name index B-C

Blood group A antigen triaose-β-Aminopropyl ...................................................................... 143 Blood group A Lewisb antigen pentaose type 1 ..................................................................... 100 Blood group A LewisY antigen pentaose type 2 ..................................................................... 100 Blood group B antigen hexaose type 1 ................................................................................ 104 Blood group B antigen hexaose type 1-β-N-Acetyl Propargyl .................................................. 144 Blood group B antigen hexaose type 2 ................................................................................ 104 Blood group B antigen pentaose type 1 ............................................................................... 103 Blood group B antigen pentaose type 2 ............................................................................... 103 Blood group B antigen pentaose type 4 ............................................................................... 104 Blood group B antigen tetraose type 1 ................................................................................ 102 Blood group B antigen tetraose type 2 ................................................................................ 102 Blood group B antigen tetraose type 5 ................................................................................ 102 Blood group B antigen triaose-β-Aminopropyl ...................................................................... 144 Blood group B Lewisb antigen pentaose type 1 ..................................................................... 102 Blood group B LewisY antigen pentaose type 2 ..................................................................... 103 Blood group H antigen disaccharide ......................................................................................97 Blood group H antigen pentaose type 1 .................................................................................98 Blood group H antigen pentaose type 2 .................................................................................99 Blood group H antigen tetraose type 1 ..................................................................................98 Blood group H antigen tetraose type 2 ..................................................................................98 Blood group H antigen tetraose type 4 .......................................................................... 98, 125 Blood group H antigen triaose type 1 ....................................................................................97 Blood group H antigen triaose type 2 ....................................................................................97 Blood group H antigen triaose type 5 ....................................................................................97 CD15 .............................................................................................................................. 105 Cellobiose ..........................................................................................................................21 Celloheptaose ....................................................................................................................22 Cellohexaose .....................................................................................................................22 Cellooctaose ......................................................................................................................22 Cello-Oligosaccharides Kit....................................................................................................22 Cellopentaose ....................................................................................................................21 Cellotetraose .....................................................................................................................21 Cellotriose .........................................................................................................................21 Chitin oligosaccharide DP2 ...................................................................................................37 Chitin oligosaccharide DP3 ...................................................................................................37 Chitin oligosaccharide DP4 ...................................................................................................37 Chitin oligosaccharide DP5 ...................................................................................................38 Chitin oligosaccharide DP6 ...................................................................................................38 Chitin oligosaccharide DP7 ...................................................................................................38 Chitin polysaccharide ..........................................................................................................37 Chitinbiose ................................................................................................................ 37, 140 Chitinheptaose ...................................................................................................................38 Chitinhexaose ....................................................................................................................38 Chitin-Oligosaccharides Kit ..................................................................................................38 Chitinpentaose ...................................................................................................................38 Chitintetraose ....................................................................................................................37 Chitintriaose ......................................................................................................................37 Chitosan oligosaccharides DP12 ...........................................................................................39 Chitosan oligosaccharides DP40 ...........................................................................................39 Chitosan oligosaccharides DP6 .............................................................................................39 Chitosan oligosaccharides DP60 ...........................................................................................39 Chitosan oligosaccharides mixture ........................................................................................39 Chitosan polysaccharide ......................................................................................................39

166



OOligoTech®® Product name index C-G

Colloidal Chitin polysaccharide .............................................................................................37 Core type 1 triaose .............................................................................................................93 Core type 2 triaose .............................................................................................................94 Core type 4 .......................................................................................................................94 Cytolipin R ....................................................................................................................... 114 DC-SIGN ECD (extra-cellular domain) ................................................................................. 160 DF-L ............................................................................................................................... 109 Difucosyllactose ............................................................................................................... 109 Difucosylpentaose ............................................................................................................ 129 Disialosylpentaose ............................................................................................................ 129 Disialyl lactose / DS-L ....................................................................................................... 119 Disialylated iGb5 analogue type 1 ....................................................................................... 135 Disialylated iGb5 analogue type 2 ....................................................................................... 135 Disialylated isoglobopentaose analogue type 1 ..................................................................... 135 Disialylated isoglobopentaose analogue type 2 ..................................................................... 135 Disialylated pentaose type 1 .............................................................................................. 116 Disialylated tetraose type 1 ............................................................................................... 115 Disialylated tetraose type 2 ............................................................................................... 117 Forssman antigen pentaose ............................................................................................... 127 Forssman antigen triaose .................................................................................................. 127 Fructofuranosyl-Nystose ......................................................................................................83 Fructo-oligosaccharide DP10 ................................................................................................84 Fructo-oligosaccharide DP11 ................................................................................................84 Fructo-oligosaccharide DP12 ................................................................................................84 Fructo-oligosaccharide DP5 ..................................................................................................83 Fructo-oligosaccharide DP6 ..................................................................................................84 Fructo-oligosaccharide DP7 ..................................................................................................84 Fructo-oligosaccharide DP8 ..................................................................................................84 Fructo-oligosaccharide DP9 ..................................................................................................84 Fructo-Oligosaccharides Kit ..................................................................................................84 Fructo-oligosaccharides mixture from Jerusalem artichoke (Cut-off< 10 kDa) ............................83 F-SL ............................................................................................................................... 109 Fucoidan oligosaccharides (Cut-off<10kDa) from Ascophyllum n. .............................................48 Fucoidan oligosaccharides (Cut-off<10kDa) from Chorda filum .................................................48 Fucoidan oligosaccharides (Cut-off<10kDa) from Durvillea a....................................................48 Fucoidan oligosaccharides (Cut-off<10kDa) from Fucus vesiculosus ..........................................48 Fucoidan polysaccharide from Ascophyllum nodosum ..............................................................47 Fucoidan polysaccharide from Chorda filum ...........................................................................47 Fucoidan polysaccharide from Durvillea antarctica ..................................................................47 Fucoidan polysaccharide from Fucus vesiculosus ....................................................................47 Fucoidan polysaccharide Kit .................................................................................................47 Fucosyl GM1 Ganglioside sugar .......................................................................................... 122 Fucosylated A antigen type 5 ............................................................................................. 130 Fucosylated B antigen type 5 ............................................................................................. 130 GA1 ................................................................................................................................ 122 GA2 ................................................................................................................................ 122 Galabiose ........................................................................................................................ 139 Galactofucan oligosaccharides (Cut-off<10kDa) from Undaria pinnatifida ..................................48 Galactofucan polysaccharide from Undaria pinnatifida .............................................................47 Galactoglucomannan polysaccharide .....................................................................................68 Galactomannan oligosaccharides DP3 from Carob ...................................................................64 Galactomannan oligosaccharides DP5 from Carob ...................................................................64 Galactomannan oligosaccharides DP9 from Carob ...................................................................64

167



OOligoTech®® Product name index G

Galactomannan polysaccharides from Carob (locust bean gum) ...............................................64 Galactomannan polysaccharides from Fenugreek ....................................................................64 Galactomannan polysaccharides from Guar ............................................................................64 Galactose-β-aminooxy ...................................................................................................... 148 Galactose-β-Aminopropyl .................................................................................................. 147 Galactose-β-Propargyl ....................................................................................................... 147 Galactosyl-lactose ............................................................................................................ 129 Galacturonan oligosaccharide block(OGAs) ............................................................................78 Galacturonan oligosaccharides Mixture DP3/DP4 ....................................................................78 Galacturonan oligosaccharides Mixture DP7/DP8 ....................................................................78 Galacturonate polysaccharides HM from apple (sodium salt) ....................................................77 Galacturonate polysaccharides HM from citrus (sodium salt) ....................................................77 Galacturonate polysaccharides LM from apple (sodium salt) .....................................................77 Galacturonate polysaccharides LM from citrus (sodium salt) ....................................................77 GalGalNac-aGM1 (GalGalNAc asialo GM1) Ganglioside sugar .................................................. 136 Galili antigen heptaose ...................................................................................................... 113 Galili antigen nonaose ....................................................................................................... 113 Galili antigen pentaose ...................................................................................................... 112 Galili antigen triaose ......................................................................................................... 112 Galili antigen undecaose .................................................................................................... 113 GalNAc-aGM1 (GalNAc-asialo GM1) Ganglioside sugar ........................................................... 136 GalNAcβ1-3Gal ................................................................................................................. 139 Galα1-3Gal ...................................................................................................................... 139 Galα1-4Gal ...................................................................................................................... 139 Galα1-4Galα1-4Gal ........................................................................................................... 140 Galα1-4Galα1-4Galα1-4Gal ................................................................................................ 140 Galα-3 epitope ................................................................................................................. 112 Galβ1-3Gal-α-aminooxy .................................................................................................... 149 Galβ1-3Gal-α-propargyl .................................................................................................... 149 Gb3 ................................................................................................................................. 124 Gb4 ................................................................................................................................. 124 Gb4 analogue ................................................................................................................... 130 Gb4 Globoside terminal ..................................................................................................... 139 Gb4-Lewisa analogue ......................................................................................................... 131 Gb4-Lewisx analogue ......................................................................................................... 131 Gb5 analogue type 1 ......................................................................................................... 131 Gb5 analogue type 2 ......................................................................................................... 131 Gb5 Triaose core structure ..................................................................................................94 GD1a Ganglioside sugar .................................................................................................... 121 GD1a Ganglioside sugar-β-N-Acetyl Propargyl ...................................................................... 146 GD1b Ganglioside sugar .................................................................................................... 121 GD2 Ganglioside sugar ...................................................................................................... 120 GD2 Ganglioside sugar-β-N-Acetyl Propargyl ....................................................................... 145 GD3 Ganglioside sugar ...................................................................................................... 119 Gentio-oligosaccharides mixture ...........................................................................................32 GF10 ..................................................................................................................................84 GF11 ..................................................................................................................................84 GF2 ...................................................................................................................................83 GF3 ...................................................................................................................................83 GF4 ...................................................................................................................................83 GF5 ...................................................................................................................................84 GF6 ...................................................................................................................................84 GF7 ...................................................................................................................................84

168



OOligoTech®® Product name index G-H

GF8 ...................................................................................................................................84 GF9 ...................................................................................................................................84 GlcNAcβ1-3Gal ................................................................................................................. 139 Globo -H tetraose ............................................................................................................. 125 Globo-A........................................................................................................................... 125 Globo-B .......................................................................................................................... 125 Globo-H .......................................................................................................................... 126 Globo-H analogue type 1 ................................................................................................... 132 Globo-H analogue type 2 ................................................................................................... 132 Globo-H-β-N-Acetyl Propargyl ............................................................................................ 147 Globopentaose (Gb5) ........................................................................................................ 126 Globopentaose analogue type 1 ......................................................................................... 131 Globopentaose analogue type 2 ......................................................................................... 131 Globotetraose .................................................................................................................. 124 Globotetraose analogue..................................................................................................... 130 Globotetraose Lewisa analogue ........................................................................................... 131 Globotetraose Lewisx analogue ........................................................................................... 131 Globotriaose .................................................................................................................... 124 Globotriaose /Gb3-β-N-Acetyl Propargyl ............................................................................... 147 Globotriaose analogue type 1 ............................................................................................. 124 Globotriaose analogue type 2 ............................................................................................. 124 Glucomannan oligosaccharides (Cut-off<10kDa) ....................................................................67 Glucomannan polysaccharide from Konjac .............................................................................67 Glucose-β-aminooxy ......................................................................................................... 148 Glucose-β-propargyl ......................................................................................................... 148 Glucurono-Arabinoxylan polysaccharide from wheat bran ........................................................51 Glucuronyl-Lacto-N-tetraose .............................................................................................. 128 Glucuronyl-lactose ............................................................................................................ 128 Glucuronyl-LNT ................................................................................................................ 128 GM1a Ganglioside sugar .................................................................................................... 120 GM1a Ganglioside sugar-β-Aminopropyl .............................................................................. 146 GM1a Ganglioside sugar-β-N-Acetyl Propargyl ...................................................................... 146 GM1b Ganglioside sugar .................................................................................................... 121 GM2 Ganglioside sugar ...................................................................................................... 120 GM2 Ganglioside sugar analogue ........................................................................................ 136 GM3 Ganglioside sugar ...................................................................................................... 119 GM3 Ganglioside sugar-β-Aminopropyl ................................................................................ 145 GM3 Ganglioside sugar-β-N-Acetyl Propargyl ....................................................................... 145 GQ3 Ganglioside sugar ...................................................................................................... 119 GT1a Ganglioside sugar..................................................................................................... 121 GT1c Ganglioside sugar ..................................................................................................... 122 GT2 Ganglioside sugar ...................................................................................................... 120 GT3 Ganglioside sugar ...................................................................................................... 119 Guluronate oligosaccharides DP10 (sodium salt).....................................................................72 Guluronate oligosaccharides DP20 (sodium salt).....................................................................72 Guluronate oligosaccharides DP3 (sodium salt) ......................................................................72 Guluronate oligosaccharides DP5 (sodium salt) ......................................................................72 Heparosan K5 polysaccharide ............................................................................................. 152 Heparosan-derived oligosaccharide DP10 ............................................................................ 153 Heparosan-derived oligosaccharide DP2 .............................................................................. 152 Heparosan-derived oligosaccharide DP4 .............................................................................. 153 Heparosan-derived oligosaccharide DP6 .............................................................................. 153 Heparosan-derived oligosaccharide DP8 .............................................................................. 153

169



OOligoTech®® Product name index H-L

High DP Cello-Oligosaccharides ............................................................................................22 HNK 1 epitope precursor ................................................................................................... 128 iGb3 ............................................................................................................................... 114 iGb4 ............................................................................................................................... 114 iGb4 analogue .................................................................................................................. 133 iGb4-Lewisa analogue ........................................................................................................ 134 iGb4-Lewisx analogue type 2 .............................................................................................. 134 iGb5 ............................................................................................................................... 114 iGb5 analogue type 2 ........................................................................................................ 134 Inulin from chicory roots .....................................................................................................83 Iota-Carrageenan polysaccharides ........................................................................................57 Isoforssman antigen pentaose ........................................................................................... 114 Isoglobo-H analogue type 1 ............................................................................................... 134 Isoglobo-H analogue type 2 ............................................................................................... 135 Isoglobopentaose ............................................................................................................. 114 Isoglobopentaose analogue type 1 ...................................................................................... 133 Isoglobotetraose .............................................................................................................. 114 Isoglobotetraose analogue ................................................................................................. 133 Isoglobotetraose Lewisa analogue ....................................................................................... 134 Isoglobotetraose Lewisx analogue type 2 ............................................................................. 134 Isoglobotriaose ................................................................................................................ 114 Isolichenan oligosaccharides (Cut-off:3<->10 kDa) ................................................................29 Isolichenan oligosaccharides (Cut-off< 10kDa) .......................................................................29 Isolichenan polysaccharide ..................................................................................................29 Kappa-Carrageenan polysaccharides .....................................................................................57 LacNAc ..............................................................................................................................94 Lactodifucotetraose .......................................................................................................... 109 Lacto-N-Biose ....................................................................................................................93 Lacto-N-difucohexaose II .................................................................................................. 107 Lacto-N-fucopentaose I .......................................................................................................98 Lacto-N-fucopentaose V .................................................................................................... 110 Lacto-N-neodifucohexaose ................................................................................................. 105 Lacto-N-neofucopentaose .................................................................................................. 110 Lacto-N-neofucopentaose I ..................................................................................................99 Lacto-N-neooctaose ............................................................................................................95 Lacto-N-neotetraose ...........................................................................................................95 Lacto-N-tetraose ................................................................................................................93 Lacto-N-Triaose..................................................................................................................94 Lactose-β-aminooxy ......................................................................................................... 148 Lactose-β-N-Acetyl Propargyl ............................................................................................. 147 Lactose-β-propargyl .......................................................................................................... 148 Lambda-Carrageenan polysaccharides ..................................................................................57 Laminaran oligosaccharide mixture (<10 kDa cut-off) .............................................................27 Laminaran polysaccharide from Fucus v. ...............................................................................27 Laminaran polysaccharide from Laminaria sp. ........................................................................27 Langerin ECD (extra-cellular domain) ................................................................................. 160 LEC401 ........................................................................................................................... 160 LecA (PA-IL) from Pseudomonas aeruginosa ........................................................................ 159 LecB (PA-IIL) from Pseudomonas aeruginosa ....................................................................... 159 Lentinan polysaccharide ......................................................................................................31 Lewisa (Lea) hexaose ......................................................................................................... 107 Lewisa (Lea) tetraose ......................................................................................................... 106 Lewisa (Lea) triaose ........................................................................................................... 106



OOligoTech®® Product name index L-N

Lewisb (Leb) pentaose ....................................................................................................... 107 Lewisb (Leb) tetraose ......................................................................................................... 107 Lewisb pentaose-β-N-Acetyl Propargyl ................................................................................. 145 LewisX (LeX) hexaose ........................................................................................................ 105 LewisX (LeX) tetraose ........................................................................................................ 105 LewisX (LeX) triaose .......................................................................................................... 105 LewisX tetraose-β-Propargyl ............................................................................................... 144 LewisY (LeY) pentaose ....................................................................................................... 106 LewisY (LeY) tetraose ......................................................................................................... 106 LFG oligosaccharide ............................................................................................................18 L-fucose .......................................................................................................................... 138 L-Fucose-α-aminooxy ....................................................................................................... 148 L-Fucose-α-propargyl ........................................................................................................ 148 L-Fucose-β-aminooxy ....................................................................................................... 148 Lichenan & Isolichenan polysaccharide Native grade ...............................................................29 Lichenan polysaccharide ......................................................................................................29 Linear B-2 trisaccharide .................................................................................................... 112 linear B-6 trisaccharide ..................................................................................................... 114 LNDFH II ......................................................................................................................... 107 LNFP I ...............................................................................................................................98 LNFP V ............................................................................................................................ 110 LNFP VI ........................................................................................................................... 110 LNnDFH .......................................................................................................................... 105 LnNFP I .............................................................................................................................99 LNnFP-V .......................................................................................................................... 110 LNnO ................................................................................................................................95 LNnT .................................................................................................................................95 LNT ..................................................................................................................................93 LNT2 .................................................................................................................................94 LSTa ............................................................................................................................... 116 LSTd ............................................................................................................................... 117 LS-Tetrasaccharide a ........................................................................................................ 116 LS-Tetrasaccharide d ........................................................................................................ 117 Maltodecaose .....................................................................................................................25 Maltodextrin oligosaccharide mixture ....................................................................................23 Maltoheptaose ...................................................................................................................24 Maltohexaose .....................................................................................................................24 Maltononaose ....................................................................................................................25 Maltooctaose .....................................................................................................................24 Malto-Oligosaccharides Kit ...................................................................................................25 Maltopentaose ...................................................................................................................24 Maltose .............................................................................................................................23 Maltotetraose .....................................................................................................................23 Maltotriose ........................................................................................................................23 Mannan oligosaccharides (cut-off<10kDa) .............................................................................61 Mannan polysaccharide (Ivory Nut or Tagua) .........................................................................61 Mannose-α-aminooxy ........................................................................................................ 149 Mannose-α-propargyl ........................................................................................................ 149 Mannuronate oligosaccharides DP10 (sodium salt) ..................................................................73 Mannuronate oligosaccharides DP20 (sodium salt) ..................................................................73 Mannuronate oligosaccharides DP3 (sodium salt) ...................................................................73 Mannuronate oligosaccharides DP5 (sodium salt) ...................................................................73 N,N’-diacetylchitobiose ...................................................................................................... 140



17 2

OOligoTech®® Product name index N-S

N-Acetyl-D-Lactosamine ......................................................................................................94 N-acetylgalactosamine ...................................................................................................... 138 N-acetylgalactosamine-α-aminooxy .................................................................................... 148 N-acetylgalactosamine-α-propargyl .................................................................................... 148 N-acetylgalactosamine-β-aminooxy .................................................................................... 148 N-acetylglucosamine-α-aminooxy ....................................................................................... 149 N-acetylglucosamine-β-aminooxy ....................................................................................... 149 N-acetylglucosamine-β-propargyl ....................................................................................... 149 N-acetylmannosamine....................................................................................................... 138 N-acetylneuraminic acid .................................................................................................... 138 neo-LNT ............................................................................................................................95 Nystose (DP4) ....................................................................................................................83 P antigen ......................................................................................................................... 124 P1 antigen ....................................................................................................................... 124 Para-Lacto-N-neohexaose ....................................................................................................95 Para-LNnH .........................................................................................................................95 Pk antigen ........................................................................................................................ 124 Pk antigen-β-N-Acetyl Propargyl ......................................................................................... 147 Pustulan polysaccharide ......................................................................................................32 Quadrisialyl lactose ........................................................................................................... 119 Reduced LFG......................................................................................................................19 Reduced XFG xyloglucan oligosaccharide (DP7) ......................................................................15 Reduced XLFGG oligosaccharide (XXLGol) ..............................................................................19 Reduced XLLFG xyloglucan oligosaccharide (DP13) .................................................................17 Reduced XLLG oligosaccharide .............................................................................................19 Reduced XXFG oligosaccharide .............................................................................................19 Reduced XXLG oligosaccharide (XXLGol) ...............................................................................18 Rhamnogalacturonan polysaccharide from gombo (sodium salt) ...............................................78 RSL from Ralstonia solanacearum ....................................................................................... 159 Scleroglucan polysaccharide ................................................................................................30 Sialic acid ........................................................................................................................ 138 Sialyl Le x precursor .......................................................................................................... 116 Sialyl Lea precursor ........................................................................................................... 115 Sialyl Lewisa (sLea) tetraose ............................................................................................... 108 Sialyl LewisX (sLeX) pentaose ............................................................................................. 108 Sialyl LewisX (sLeX) tetraose .............................................................................................. 107 Sialyl LewisX pentaose-β-Propargyl ..................................................................................... 144 Sialylated globotriaose ...................................................................................................... 125 Sialylated iGb5 analogue type 1 .......................................................................................... 135 Sialylated iGb5 analogue type 2 .......................................................................................... 135 Sialylated isoglobopentaose analogue type 1 ....................................................................... 135 Sialylated isoglobopentaose analogue type 2 ....................................................................... 135 Sialylated tetraose type 1 .................................................................................................. 115 Sialylated tetraose type 2 .................................................................................................. 116 Sialylated triaose type 1 .................................................................................................... 115 Sialylated triaose type 2 .................................................................................................... 116 Sialylated-SSEA-4 hexaose analogue type 1 ........................................................................ 133 Sialylated-SSEA-4 hexaose analogue type 2 ........................................................................ 133 Sialyl-lacto-N-tetraose a .................................................................................................... 116 Sialyl-lacto-N-tetraose d ................................................................................................... 117 Spirulan polysaccharides Fine Grade .....................................................................................86 SSEA-1 ........................................................................................................................... 105 SSEA-3b-β-N-Acetyl Propargyl ........................................................................................... 147



OOligoTech®® Product name index S-X

SSEA-4 hexaose ............................................................................................................... 126 SSEA-4 hexaose analogue type 1 ....................................................................................... 132 SSEA-4 hexaose analogue type 2 ....................................................................................... 132 SSEA-4 tetraose ............................................................................................................... 126 Stage Specific Embryonic Antigen 3a (SSEA-3a) ................................................................... 126 Stage Specific Embryonic Antigen 3b (SSEA-3b)................................................................... 126 Stage-Specific Embryonic Antigen-4 ................................................................................... 126 Starch ...............................................................................................................................25 Sulfated Arabinogalactan oligosaccharides (Cut-off: 3kDa<->10kDa) .......................................55 Sulfated Arabinogalactan oligosaccharides (Cut-off<10kDa) ....................................................55 Sulfated Arabinogalactan oligosaccharides (Cut-off<3kDa) ......................................................55 Sulfated Arabinogalactan polysaccharide (from Codium f.) Fine grade .......................................55 Sulfated Arabinogalactan polysaccharide (from Codium f.) Native grade ....................................55 Sulfated heteropolysaccharides fine grade .............................................................................88 Sulfated heteropolysaccharides native grade ..........................................................................88 Sulfated Xylomannan polysaccharides ...................................................................................62 TF antigen analogue-α-aminooxy ....................................................................................... 149 TF antigen analogue-α-propargyl ........................................................................................ 149 Tn antigen analogue-α-propargyl ........................................................................................ 148 Tn antigen analogue-β-aminooxy ....................................................................................... 148 Trisialyl lactose ................................................................................................................ 119 Trisialylated pentaose type 1 ............................................................................................. 115 Trisialylated pentaose type 2 ............................................................................................. 117 Ulvan oligosaccharides (cut-off: 1<->3kDa ) from Enteromorpha sp. ........................................44 Ulvan oligosaccharides (cut-off: 1<->3kDa ) from Ulva sp.......................................................44 Ulvan oligosaccharides (cut-off: 3<->5kDa) from Enteromorpha sp. .........................................44 Ulvan oligosaccharides (cut-off: 3<->5kDa) from Ulva sp. ......................................................44 Ulvan oligosaccharides (cut-off: 650 Da<->1kDa) from Enteromorpha sp .................................44 Ulvan oligosaccharides (cut-off: 650 Da<->1kDa) from Ulva sp. ..............................................44 Ulvan oligosaccharides (cut-off<10kDa) from Enteromorpha sp. ..............................................44 Ulvan oligosaccharides (cut-off<10kDa) from Ulva sp. ............................................................43 Ulvan polysaccharides from Enteromorpha sp. Fine grade ........................................................43 Ulvan polysaccharides from Enteromorpha sp. Native grade ....................................................43 Ulvan polysaccharides from Ulva sp. Fine Grade .....................................................................43 Ulvan polysaccharides from Ulva sp. Native grade ..................................................................43 Xanthan gum polysaccharide ...............................................................................................34 Xeno antigen type 1 ......................................................................................................... 112 Xeno antigen type 2 ......................................................................................................... 112 Xeno Lewisa ..................................................................................................................... 113 Xeno lewisX ...................................................................................................................... 113 XFG xyloglucan oligosaccharide (DP7) ...................................................................................15 XFG(Ac) ............................................................................................................................16 XFGol ................................................................................................................................15 XLFG xyloglucan oligosaccharide (DP10) ...............................................................................16 XLFG(Ac) ...........................................................................................................................17 XLFGG oligosaccharide ........................................................................................................19 XLG oligosaccharide ............................................................................................................18 XLLFG xyloglucan oligosaccharide (DP13) ..............................................................................17 XLLFG(Ac) .........................................................................................................................18 XLLFGol ............................................................................................................................17 XLLG oligosaccharide ..........................................................................................................19 XXFG oligosaccharide ..........................................................................................................19 XXLG oligosaccharide ..........................................................................................................18



OOligoTech®® Product name index X-α

Xylan oligosaccharides XOs (cut-off: 650Da<->3kDa) from Palmaria p. ....................................51 Xylan oligosaccharides XOs (Cut-off<10kDa) from Palmaria p. .................................................51 Xylan polysaccharide from Palmaria palmata..........................................................................51 Xyloglucan oligosaccharides .................................................................................................15 Xyloglucan oligosaccharides available upon request ................................................................18 α1-3 galactobiose ............................................................................................................. 139 α1-3Galactosyl-3Fucosyllactose .......................................................................................... 110 α1-4 galactobiose ............................................................................................................. 139 α1-4Gal-3Fucosyllactose ................................................................................................... 111 α-Digalactosyl mannopentaose .............................................................................................65 α-galactosyl Mannobiose & Mannotriose ................................................................................65 α-galactosyl Mannotriose .....................................................................................................65 α-Gal-Lewisa .................................................................................................................... 113 α-Gal-LewisX .................................................................................................................... 113



OOligoTech®®

Sale Terms & Conditions



OOligoTech®®

OOligoTech Sale Terms and Conditions (1/2) These conditions apply to all sales of goods by Elicityl (The Seller) to any Purchaser (The Buyer), whatever is the nationality of the Buyer. In placing its order with the Supplier, the Buyer has accepted all of the general terms & conditions of sale as described herein, notwithstanding any proposed change in terms contained in its own purchasing documents.

Ordering. We will only accept orders from Companies, Universities and Colleges, Research Institutes, Hospitals, Government Agencies. We cannot supply retailers, wholesalers, brokers or individuals. The Buyer agrees that the Products sold and delivered to the Buyer hereunder are to be used solely for Buyer's proper use and are not to be resold or used by customer for any other purpose or in any other manner whatsoever. Buyer’s orders are thereafter subject to our written acceptance, and, prior to such acceptance, may be refused or canceled by us for any reason, including our inability to supply, or if the customer could not be identified.

Orders may be placed by mail, fax, e-mail, through our website (www.elicityl-oligotech.com). Orders should be accompanied by a delivery and invoicing address, a Purchase Order Number, a confirmation of the acceptation of the price of products, delivery cost and our present Terms and Conditions. Elicityl validates the order by sending an acknowledgement receipt of order. Ordering by e-mail at [email protected]. Ordering by fax on +33 (0)4 76 45 59 50. Customers can order by mail to the following address: Elicityl, 746 avenue Ambroise Croizat, F-38920 Crolles, France.

Products. Our products are supplied solely for research purpose and for use in the laboratory by experienced and qualified personnel. They are not intended for human consumption; in particular they are not for nutritional, drug use or human experimentation. They are not intended for resale. Any other use has to be approved and confirmed in written by Elicityl.

All or products should be handled by qualified personnel only; trained in laboratory procedures, and familiar with potential hazards. Information is not available on the possible hazards of many compounds. The absence of a warning must not be interpreted as indication of safety. The ultimate responsibility for the proper handling of any product lies with the user.

Prices. All prices are listed in Euros. Duty, applicable taxes, freight charges and any special packaging charges are excluded and will be added to the invoice. Products and prices are correct at the time of printing and order on the web site but are subject to change without notice. The prices payable for the goods shall be those contained in the Seller’s price list current at the time of dispatch, or confirmed on request by the Seller. Quotations are valid for 60 days from the date on the quotation. Prices for orders placed after this period must be re-confirmed by the Seller. We overcharge transportation cost and any applicable taxes to the customer. Local custom fees and VAT will be separately invoiced by Transport Company or forwarding agent.

Payment. Prepaid orders (credit card or checks): Elicityl generally ships the product within two open days, customer receiving the product within one week (Europe) to two weeks when the stock is available. See also Availability.

Credit orders: For new customers, credit acceptance has to be confirmed by Elicityl prior to shipment. Our payment terms are usually within 30 days of the date of invoice. Payment may be made in Euros by Credit Card through Paypal, electronic transfer or cheque to Elicityl or to our current factoring agent, as mentioned on the invoice. We will not accept deduction of the customer’s own bank charges. Unpaid balances shall be subject to interest at the rate of 3 times the French applicable legal rate from the invoice date. In addition, the Supplier may, after giving eight (8) days written notice, suspend the supply of any Products without liability until all past due accounts (including fees and accrued interest) have been paid. The Supplier does no pay any rebate for early payment.

Data Sheets. All orders dispatched will be accompanied by product data sheets. The specifications are made on the base of our best knowledge and the seller shall have no liability for any deviation from this. The seller accepts no liability for any errors. To complete the data sheet and in accordance with the regulation, the Buyer shall provide assistance to the Supplier in connection with the collection of Information in connection with the Products complete and deliver on first request, a “Information Form” provided by the Supplier.

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17 8

OOligoTech®®

OOligoTech Sale Terms and Conditions (2/2) Shipping. Delivery dates mentioned in any quotation, acknowledgement of order or elsewhere are approximate only and not of any contractual effect and the Seller shall not be under any liability to the Buyer in respect of any failure to deliver on any particular date or dates. In case of inability of the Seller to deliver the products eight (8) weeks after the Purchase Order, the Buyer will be informed. Small orders will be sent by mail or registered mail. Most orders will be sent by international registered courier. The Buyer shall meet the cost of any special packaging requested by the Buyer for any packaging rendered necessary for delivery by any means other than the Seller’s normal means of delivery. Whenever authorizations concerning import, exchange transactions or other formalities are required for the importation of our Products into the country of destination, or for the payment thereof, the obtaining of such authorizations and compliance therewith within the applicable time period is at the sole expense and complete responsibility of the Buyer. Partial shipment: In the event that a complete order cannot be shipped, a partial shipment will be made at our discretion. Customer must indicate at the time an order is placed in the event that a partial shipment is not acceptable. An invoice will be processed for each partial shipment. Shipping fees will be invoiced only once, on the first invoice.

Storage. Our products are mainly sold as freeze dried. Most products are stable for some years at ambient temperature, provided they are not opened and the seal is not broken.

Variation. The Seller shall be determined to have fulfilled its contractual obligations in respect of any delivery though the quantity may be up to 10% more or less than the quantity specified in the contract and in such event the Buyer shall pay for the actual quantity delivered.

Availability. Some products require lengthy re-make periods and sometimes are derived from raw materials which have uncertain or intermittent availability. They may therefore be unavailable for considerable periods of time. The buyer cannot drive any right from any delay, which is no longer than two months (one month in case of prepayment). Thereafter, the buyer’s rights are limited to cancellation of the undelivered part of the order, prepayments are refunded.

Distribution. Some products could be delivered by local distributors. In this case the Seller informs the Purchaser of the name and the contact of the distributor.

Warranty. In case of proven default in a product or delivery, the Seller’s responsibility cannot exceed the replacement of the delivered product by a conform one. The Supplier shall not in no event be liable for any lost, damage, delay, costs, diminished profits, revenues, or opportunities; or any other incidental, special, indirect, or consequential damages of any kind or nature whatsoever arising from the contract supported by the Buyer. Buyer must notify the Seller within five days after the products have been received or such products shall be deemed to have been accepted. Any return of product is subject to prior agreement between the Buyer and the Seller. Any product return without such agreement will be kept in custody and will not give rise to any reimbursement. All costs and expenses connected to such return will be charged to the Buyer.

Intellectual Property. The Buyer shall not use the Seller’s Intellectual Property Rights in a manner that disparages the other party or its products or services, blurs, dilutes or otherwise diminishes the Seller's trade names, trademarks, service marks or other intellectual property, or portrays the Seller or its products or services in a false, competitively adverse or poor light. The Buyer shall comply with the Seller's requests as to the use of the Seller’s Property Rights and will avoid any action that diminishes the value of such marks. Without limiting the foregoing, the Buyer shall not, without written permission from the Seller use any of the Seller's brand names, keywords or derivations of either of the above for any purpose.

Governing Law. This contract shall be governed in all respects by the French laws and the parties hereby submit to the jurisdiction of the Grenoble Court.

Derogation. Any derogation to these terms and conditions are specified in written in the quotation signed by Elicityl.

These Sale Terms and conditions are subject to change without notice.

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746 avenue Ambroise Croizat F-38920 Crolles - France

tel: +33 (0) 4 76 40 71 61 fax: +33 (0) 4 76 45 59 50

[email protected] www.elicityl-oligotech.com

SA à Directoire et Conseil de Surveillance Siret: 442 055 893 00022. Code APE: 7211Z

Intra-community VAT number: FR 844 420 558 93

© 2012 Elicityl SA. All rights reserved. Oligotech Product catalogue 4th Edition, July 2012.

Printed on 100% recycled paper with vegetable-based inksImprimerie Notre-Dame France

glycoproducts for life sciences - elicityl contact us for bulk quantities - [email protected] -...

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