gout a metabolic disease in which tissue deposition of crystals of monosodium urate occurs from...
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GOUT A metabolic disease in which tissue deposition of crystals of monosodium
urate occurs from supersaturated extracellular fluids and results in one or more clinical manifestations.
These include:1: GOUTY ARTHRITIS Reccurent attacks of severe acute or chronic articular or periarticular
inflammation
2: GOUT TOPHI accumulation of articular, osseous, soft tissue and cartilaginous crystalline
deposits
3: GOUTY NEPHROPATHY renal impairment
4: URIC ACID CALCULI in the urinary tract
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Gout-uric acid
• Uric acid is the breakdown product of the purine residues of nucleid acid
• Two-thirds is excreted via the kidney and the rest via the gut
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Gout
• Primary gout• Secondary gout-increase dietary intake of purines-overproduction e.g. Myelo- and
lymphoproliferative disorders-decrease renal excretion in renal
failure or tubular excretion
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ACUTE GOUTY ARTHRITISAn acute attack of gout is a dramatic, very painful
condition
typically ache and inflammation in one big toe
The joint is : swollen, red hot very painful
The joint slowly returns to normaloften with desquamation and peeling of the overlying skin
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ACUTE GOUTY ARTHRITIS-treatment
• NSAIDs are useful during acute attacks
• Colchicine
• Intra-articular steroids
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CHRONIC TOPHACEOUS GOUT
Tophi-small chalky deposits appearing on the:earshandsaround MTP joints olecranon bursae
If the condition is still not treated Gross knobbly swelling develop and may:
ulceratebecome secondarily infectedcause severe restriction of
movement
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