GP4-5: Circulating levels of insulin-like growth factor-1(IGF-I)/insulin-like growth factor binding protein-3 (IGFBP-3) in obese patients: the state of type 2 diabetes

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<ul><li><p>S48 Posters / Growth Hormone &amp; IGF Research 22S1 (2014) S25S52 </p><p>Results: Plasma PAPP-A increased abruptly upon heparin-admin-istration with mean concentrations pre-PCI, post-PCI, day 1 and day 2 of 13 .0 (11 .2; 15 .2), 14 .8 (13 .1; 16 .8), 1 .03 (0 .902; 1 .18) and 1 .08 (0 .916; 1 .28) mg/l, respectively (p</p></li><li><p> Posters / Growth Hormone &amp; IGF Research 22S1 (2014) S25S52 S49</p><p>2) Serum IGF-I level was no significantly different between obese and non-obese groups in all subjects, NGT and T2DM groups . It was correlated with serum IGFBP-3 and age in NGT group . And it was showed positive correlation with HbA1c and FPG, OGTT glucose levels but negative correlation with age in T2DM group .</p><p>3) Serum IGFBP-3 level was significantly increased in obese than non-obese groups in all subjects . But it was no significantly different between obese and non-obese groups in NGT and T2DM groups . It had positively associated with age and BMI in NGT group . In T2DM group, it had positive correlation with FPG, HbA1c and lipid profile but no correlation with IGF-I level .</p><p>Conclusion: Serum IGF-I and IGFBP-3 levels were significantly elevated in adolescents with type 2 diabetes and correlated with blood glucose related factors . Serum IGFBP-3 level was associ-ated with lipid profile . These findings suggest that IGFBP-3 may related glycemic control and/or obesity in adolescents .</p><p> GP4-6Effects of GH/IGF-I axis on retinal vascular morphology: retinal vascular morphology in Laron syndrome</p><p>H .T . Sekeroglu1, S . Kadayifcilar1, B . Kasim1, U . Arslan2, Z .A . Ozon3 . 1Department of Ophthalmology, Hacettepe University, Faculty of Medicine, Ankara, Turkey, 2Department of Biostatistics, Hacettepe University, Faculty of Medicine, Ankara, Turkey, 3Department of Pediatrics Division of Endocrinology, Hacettepe University, Faculty of Medicine, Ankara, Turkey</p><p>Introduction: IGF-I is suggested to be a critical mediator of reti-nal neovascularization with other growth factors . We aimed to study retinal vascular characteristics of patients with Laron syn-drome (LS) as a genetic model of severe IGF-I deficiency before and after rhIGF-I/IGFBP-3 treatment, and to compare them with retinal vascular morphology of healthy age matched controls .Methods: A total of 28 subjects (11 LS, and 17 age-matched healthy controls) were enrolled . All subjects underwent oph-thalmological examination including digital fundus imaging . Patients with LS received combined rhIGF-I/rhIGFBP-3, 1-2 mg/kg/d in a single dose subcutaneously for one (5 patients) or two (6 patients) years, and digital fundus imaging was repeated at the end of treatment . Branching characteristics and tortuosity index of retinal vessels were studied in all subjects by a blinded retina specialist . Pre- and post-treatment findings were compared with each other and with controls .Results: Number of branching points was significantly lower in LS in comparison to controls (12 .733 .41, and 17 .475 .82 respectively, p=0 .012) . This difference persisted after treatment (12 .092 .66 posttreatment LS vs controls, p=0 .017) . Tortuosity indices of nasal arteries (NA) were significantly less in LS than that of controls (upper NA 1 .070 .04 and 1 .120 .06 respectively p= 0 .022; lower NA 1 .070 .03 and 1 .130 .07 respectively, p=0 .004) . This difference also persisted following treatment (p</p></li></ul>

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