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INFORMATION BULLETIN: GPAT 2020

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INFORMATION BULLETIN

GPAT 2020

(GRADUATE PHARMACY APTITUDE TEST)

Important Dates

Address for correspondence Block C-20/1A/8, Sector 62,

Gautam Budh Nagar, Noida -201309 (UP)

EVENTS DATES On-line submission of Application Form

01.11.2019 to 30.11.2019(upto 11.50 p.m.)

Successful transaction of fee 01.11.2019 to 01.12.2019 (through Credit card/Debit card/Net banking/UP and PAYTM service upto 11.50 p.m.)

Choice of City 01.11.2019 to 02.12.2019 (upto 11.50 p.m.)

Date of Examination 28th January,2020

Timing of the Examination 02.30 p.m. to 05.30 p.m.

Declaration of Result By 07th February 2020

Help Line: For Technical Support, contact following during working days between 10.00 a.m. to 5.00 p.m.

Call Centre Numbers: 0120-6895200

Website: www.nta.ac.in and gpat.nta.nic.in email: [email protected]

Note: For any Query use the Register Query Link in the Menu TAB of Candidate Login Page.

http://www.nta.ac.in/

mailto:gpat.nta.nic.in


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CONTENTS SR DETAILS PAGE#

1 Introduction & Scheme of Examination 2

2 GPAT- 2020 Eligibility 2

3 Reservations 3-4

4 Schedule for Events with dates 4

5 Instructions for filling Online Application Form 5-6

6 Test Pattern 7

7 Syllabus 7

8 Allotment of Test City/Centre for GPAT – 2020

Examination

8

9 Display of Provisional Answer Keys for Challenge and

Question Paper Attempted

8

10 GPAT Score 9

11 Test Practice Centres 9

12 Query Redressal System (QRS) 10

13 Code of Conduct for Candidates 10

14 Guidelines to Candidates for Computer Based Test 11-12

15 Weeding Out Rules 12

16 Legal Jurisdiction 12

Appendix-I: Certificate regarding physical limitation in an examination to write

Appendix-II: Letter of Undertaking for Using Own Scribe

Appendix-III: List of examination Cities for GPAT-2020

Appendix-IV Service/Processing Charges & Goods & Service Tax (GST) and Procedure for Payment of Fees


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INTRODUCTION & SCHEME OF EXAMINATION

NATIONAL TESTING AGENCY (NTA) had successfully conducted the GRADUATE PHARMACY APTITUDE

TEST - 2019 (GPAT-2019) for admission to various M. pharma or its equivalent courses across the

country. The 800 participating institutes of GPAT-2019 were the institutions which had accepted the

GPAT Score.

The GPAT 2020 will be conduct by National Testing Agency (NTA) on the same pattern as per the Year

2019 i.e., Computer Based Test on January 28, 2020 from 02.30 p.m. to 05.30 p.m. for admission to M.

pharma or its equivalent courses across the country. The result of GPAT-2020 will be declared by

February 7, 2020 as GPAT Score which will be accepted by over 800 participating Institutes. The

participating Institutes of GPAT-2020 are the Institutions which will be accepting the GPAT Score.

Candidates must apply separately to the desired GPAT-2020 participating institutes with the GPAT Score

2020. Then, each participating institute will release their respective cut – off GPAT Score which

candidates should meet to get qualified for admission to that particular institute. Candidates are

advised to see the details of the admission process of each participating institute of GPAT-2020 on their

respective website.

GPAT Website: gpat.nta.nic.in

Helpline number: 0120-689-5200 Email: [email protected]

GPAT - 2020 ELIGIBILITY

The candidate must hold a bachelor’s degree in pharmacy (4 years after 10+2, including lateral entry

students) or equivalent from a recognized university. Candidates appearing for the final year of

bachelor’s degree B. Pharmacy (10+2+4) whose result will be declared before commencement of

admission for academic year 2020-21 can also apply for GPAT - 2020 computer-based test (CBT).

B.Tech. (Pharmaceutical and Fine Chemical Technology)/ equivalent candidates are not eligible to apply.

The candidate must be a citizen of India. There is no age restriction for appearing in GPAT - 2020.

http://www.ntagpat.nic.in/


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RESERVATIONS

For admission to a participating institute, please see the reservations applicable in that particular

institute. In case of institutes run by Central Government,10% of the seats are reserved for Category

General-Economically Weaker Section(GEN-EWS), 15% of the seats are reserved for the category

Scheduled Caste (SC), 7.5% for the category Scheduled Tribe (ST) and 27% for the category Other

Backward Classes belonging to the “ Non Creamy layer” (OBC-NCL). Each category will have 5%

horizontal reservations for Persons with Disabilities (PwD) as defined in The Rights of Persons with

Disabilities Act, 2016 (RPwD Act 2016).

Other Backward Classes - Non Creamy Layer (OBC–NCL) are as per the Central list of Other Backward

Classes available on National Commission for Backward Classes (NCBC), Government of India website

www.ncbc.nic.in Thus, the candidates falling in this list may mention OBC in the Category Column. State

list OBC Candidates who are not in OBC-NCL (Central List) must choose General.

Section 2(r) of the RPwD Act, 2016 states the following:

Persons with benchmark disabilities (PwD) means a person with not less than forty percent (40%) of a

specified disability where specified disability has not been defined in measurable terms and includes a

person with disability where specified disability has been defined in measurable terms, as certified by

the certifying authority. “Specified Disability” means the disabilities as specified in the Schedule of the

RPwD Act 2016. The categories of disabilities are:

1. Blindness and low vision

2. Deaf and hard of hearing

3. Locomotor disability including cerebral palsy, leprosy cured, dwarfism, acid attack victims and

muscular dystrophy

4. Autism, intellectual disability, specified learning disability and mental illness, and

5. Multiple disabilities from amongst persons under clauses (i) to (iv)

6. Other ‘specified disabilities’ mentioned in the Schedule of the RPwD Act 2016.

Please refer to Office Memorandum issued by Ministry of Social Justice & Empowerment dated 29

August 2018 (F.No.34-02/2015-DD-III), guideline IV, second paragraph quoted below:

The facility of Scribe/Reader/Lab Assistant should be allowed to any person with benchmark disability

as defined under section 2(r) of the RPwD Act, 2016 and has limitation in writing including that of speed

if so desired by him/her.

http://www.ncbc.nic.in/


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In case of persons with benchmark disabilities in the category of blindness, Locomotor disability (both arm affected-BA) and cerebral palsy, the facility of scribe/reader/lab assistant shall be given, if so desired by the person. In case of other category of persons with benchmark disabilities, the provision of scribe/reader/lab assistant can be allowed on production of a certificate to the effect that the person concerned has physical limitation to write, and scribe is essential to write examination on his behalf, from the Chief Medical Officer/Civil Surgeon/Medical Superintendent of a Government health care institution as per performa at Appendix I. The order further allows the candidate to opt for their own scribe/reader provided the qualification of the scribe is one step below the qualification of the candidate taking the examination. The candidate with bench-mark disabilities opting for their own scribe/reader should submit details of their own scribe as per performa at Appendix II. One hour compensatory time will be allowed to the Candidates who are availing the facility of scribe/reader/lab assistant. The reservation policy, as announced by the government from time to time will be followed by the admitting institutes. The candidates are advised to look for the details at the time of admission. Important Note: No change in the category will be entertained after the last date of GPAT 2020 application form

SCHEDULE FOR EVENTS WITH DATES

Procedure for Payment of Fees and Service/ Processing Charges & Goods & Service Tax (GST) to be paid, are given in Appendix-IV

EVENTS DATES On-line submission of Application Form (Upto 11.50 p.m.)

01.11.2019 to 30.11.2019

Date for successful final transaction of fee

01.11.2019 to 01.12.2019 (through Credit/ Debit Card/ Net Banking/UPI/PayTM service up to 11.50 p.m. up to bank hours)

Fee payable for GPAT - 2020

General/Gen-EWS/OBC (NCL) Boys - Rs 1600/- Girls – Rs. 800/-

SC/ST/PwD/ Transgender Boys - Rs 800/- Girls – Rs. 800/-

Service/Processing charges & Goods & Service Tax (GST) are to be paid by the candidate, as applicable.

Date for Choice of City 01.11.2019 to 02.12.2019 (11.50 p.m.)

Date of Examination 28th January, 2020 (Tuesday)

Timing of Examination 02.30 p.m. to 05.30 p.m.

Printing of Admit Cards from NTA’s website From 24th December, 2019

Display of recorded responses and Answer Keys for inviting challenges on NTA’s website

Date shall be displayed on the NTA’s website

Declaration of Result on NTA’s website By 07th February, 2020


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INSTRUCTIONS FOR FILLING ONLINE APPLICATION FORM

Candidates have to apply for GPAT- 2020 “Online” ONLY by accessing the website

gpat.nta.nic.in.The Application Form other than online mode would not be accepted, in any case.

Only one application is to be submitted by a candidate. More than one application i.e. Multiple

application forms submitted by a candidate will be rejected

It is suggested that you have the following ready before starting the filling of the application form:

• A computer with good Internet connectivity

• All your qualification details

• Scanned clear passport photograph in JPG/JPEG format (size between 10 kb–200 kb)

• Scanned clear signature in JPG/JPEG format (size between 4 kb–30 kb)

• A valid e-mail Id as all communication will be made on this e-mail Id

• A valid mobile number as all information via SMS will be sent to this number

• A valid debit/credit card or Net banking account for online payment

• A printer connected to your system to print confirmation page

➢ Download information Bulletin. Read it carefully to ensure your eligibility and acquaint with the requirements for submission of Online Application Form.

➢ No corrections can be made at a later stage after submission of an application. No change will

be accepted through offline mode i.e. through fax/application including e-mail etc.

➢ Follow following 5 (Five) Steps to Apply Online: Step-1: Fill in the online Application Form and Note down the system generated Application

Number Step-2: Upload scanned images of Candidate’s Passport size Photograph (between 10 kb–

200 kb) and Candidate’s Signature (between 4kb – 30 kb) in JPG/JPEG format. Step-3: Make payment of fee using Credit/Debit Card, Net Banking, UPI, PayTM and keep

proof of fee paid. Step-4: Print at least four printout of Confirmation Page after successful remittance of fee Step-5: Choose the city for giving the examination GPAT-2020

➢ All the 5 Steps can be done together or separately also.



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Note: (i) The final submission of online Application form will remain incomplete if Step - 2

Step - 3, Step - 4 and Step - 5 are not completed. Such forms will stand rejected and no correspondence on this account will be entertained.

(ii) No request for refund of fee once remitted by the candidate will be entertained (iii) The entire application process of GPAT - 2020 is online, including uploading of

scanned images, Payment of Fees and Printing of Confirmation page. Therefore, candidates are not required to send/submit any document(s) including Confirmation page to NTA through Post/Fax/ By Hand/E-mail.

(iv) Candidates are advised to keep visiting the NTA’s website regularly for latest updates and to check their e-mails.

(v) The NTA can make use of the data generated for the purpose of research and analysis.

All the candidates who have submitted the online application and paid the examination fee till last date will be allowed to appear in GPAT - 2020 and their admit cards will be uploaded on the website as per schedule. The NTA do neither verify the information filled by the candidates in the application form nor verify any certificate of category/educational qualification for deciding the eligibility of candidates. The certificates of educational qualification and category (if applied under reserved category) will be verified by the concerned institution. The candidates are, therefore, advised to ensure their eligibility and the category (if applying under reserved category). The NTA will, in no way, be responsible for any wrong/incorrect information furnished by the candidate(s) in their online application form. The letter/e-mails in this regard will not be entertained by the NTA.

The candidates are required to check the status of fee payment at NTA website (gpat.nta.nic.in) and if the status is ‘OK’ the candidate will be able to take the printout of Confirmation Page. In case, the fee payment status is not ‘OK’ the candidates are advised as following: -

• If the fee is paid through credit/debit card and status is not OK, it means the

transaction is cancelled and the amount will, automatically, be refunded to

concerned credit/debit card within 15 days. Therefore, such candidates have to pay

the fee once again and ensure the OK fee status.


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TEST PATTERN

The medium of Question Paper shall be in English only.

GPAT is an online computer-based test of 3 hours duration with 125 objective type questions.

Important Note:

i) Each question carries 04 (four) marks.

ii) For each correct response candidate will get 04 (four) marks.

iii) For each incorrect response 01 (one) mark will be deducted from the total score.

iv) To answer a question, the candidates need to choose one option corresponding to the

correct option.

v) However, after the process of challenges of the key, if more than one option is found to

be correct then the multiple correct options will be given the four marks (+4).

Any incorrect option marked will be given the minus one mark (-1). Un-answered/Un-attempted

will be given no marks. In case, a question is dropped/ignored, all candidates will be given four

marks (+4) irrespective of the fact whether the question has been attempted or not attempted

by the candidate.

At the test Centre, each candidate will be seated at a desk with a computer terminal and he/she will be provided with rough papers for calculations and a PEN. After the test, candidate must leave the rough papers at the desk. Rough work cannot be done on any other paper/sheet, as nothing will be allowed inside the examination room/hall.

SYLLABUS

Details are given on the link https://gpat.nta.nic.in/WebInfo/Handler/FileHandler.ashx?i=File&ii=103&iii=Y

Candidates are NOT allowed to carry Instrument/ Geometry/ Pencil box, Handbag, Purse, Any kind of Paper/ Stationery/ Textual material (printed or written material), Eatables and Water (loose or packed), Mobile Phone/ Ear Phone/ Microphone/ Pager, Calculator, Camera, Tape Recorder, any metallic item or electronic gadgets etc. in the examination Room/ Hall.


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The Cities where the GPAT – 2020 will be conducted are given in Appendix-III

DISPLAY OF PROVISIONAL ANSWER KEYS FOR CHALLENGE AND QUESTION PAPER

ATTEMPTED

After the GPAT - 2020 examination, the NTA will display answer keys & Question Paper attempted by the candidate on the NTA’s website gpat.nta.nic.in. The details of the date shall be displayed on the NTA’s website. The candidates, who are not satisfied with provisional answer keys, may challenge by filling online application form and paying a processing charge of Rs.1000/- per question. The processing charge can be paid by credit/debit card/Net banking. The processing charge once paid is non-refundable. The NTA’s decision on the answer keys challenges shall be final and no further communication will be entertained.

ALLOTMENT OF TEST CITY/CENTRE FOR GPAT-2020 EXAMINATION

The City for examination will be chosen by the applicants after submission of examination fees

on first come- first served basis. However, before submitting the fees candidate can check the

availability of the seat. It may be noted that if the last few seats are available in a city, these

may get filled by the time of completing the payment formalities.

The applicants can choose any available city which will be immediately allotted to the applicant.

Please note that this will be active only after payment of fees.

There will be a drop down list of States then choose the city where the applicant wishes to give

the examination in online computer based test mode.

The city of examination once chosen and allotted cannot be changed and any request in this

regard will not be entertained.

NTA will allocate the examination centre in the chosen city, which will be displayed in the admit

card.

NTA may change the chosen city and/or the allocated centre for logistic and administrative

reasons.



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GPAT SCORE

The result will be compiled on the basis of final answer keys. No grievance with regard to answer key(s) after declaration of result of GPAT-2020 will be entertained. The raw (actual) marks obtained by a candidate will be considered further for computation of the result of GPAT-2020. No score card will be dispatched to the candidates and the candidates are advised to download their score cards from the website: gpat.nta.nic.in only. There shall be no provision for re-valuation/re-checking of the Score. No correspondence in this regard shall be entertained.

The National Testing Agency (NTA) is an examination conducting body and will provide GPAT Score 2020. The NTA does not collect the information regarding total number of seats available in the institutions and reservation criteria followed by the institutions. Rules for tie-breaking:- In case of a tie among candidates with equal marks, it will be resolved by the following in descending order:

• Marks Obtained in Pharmaceutics

• Marks obtained in Pharmaceutical Chemistry

• Candidates having less negative responses in the paper.

• Candidates older in age. .

TEST PRACTICE CENTRES

National Testing Agency (NTA) has established a network of Test Practice Centres spread all over India to help the students aspiring to appear in examinations to be conducted by the NTA from 2020 onwards. The students can practice and train themselves before the examination for the “Computer Based Test (CBT)” mode of examinations.

The experienced, qualified and professional Nodal officer and staff available at the TPC will help and motivate the students to clear their doubts and solve problems and to make them familiar with the CBT mode of examinations.

For details see the NTA Website www.nta.ac.in




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QUERY REDRESSAL SYSTEM (QRS)

National Testing Agency (NTA) has established a Query Redressal System (QRS), an online web-enabled system developed by NTA. QRS is the platform based on web technology which primarily aims to enable submission of queries/grievances by the Registered Candidate(s) of GPAT-2020 Examination with (24x7) facility for speedy and favourable redressal of the queries/grievances. A Unique Registration Number will be generated for tracking the status of the queries/grievances. The Registered Candidate(s) are advised to use the online facility for speedy and favorable response before mailing their queries on the official email id of GPAT i.e. [email protected]

CODE OF CONDUCT FOR CANDIDATES

Candidates shall maintain perfect silence and attend to their Question Paper only. Any

conversation or gesture or disturbance in the Examination Room/Hall shall be deemed as misbehavior. If a candidate is found using unfair means or impersonating, his/her candidature shall be cancelled and he/she will be liable to be debarred for taking examination either permanently or for a specified period according to the nature of offence.

Candidates are not allowed to carry any textual material, Calculators, Docu Pen, Slide Rules, Log Tables, and Electronic Watches with facilities of calculator, printed or written material, and bits of papers, mobile phone, pager or any other device, except the Admit Card inside the Examination Room/Hall. If any candidate is in possession of any of the above item, his/her candidature will be treated as unfair means and his/her current examination will be cancelled & he/she will also be debarred for future examination(s) & the equipment will be seized.

The Candidates, especially those who are carrying the barred items, including the metallic objects such as Kara and Kirpan etc., should report their respective Examination Centers one and half hour before the gate closing time, for ensuring timely checking/frisking and entry to the Examination Hall.

If upon screening at the Examination Centre, it is discovered that any candidate is actually carrying, within the ‘Kara’ and ‘Kirpan’, a suspect device, he/she may be asked not to take it in the Examination Hall (as directed by the Hon’ble Delhi High Court vide its Order dated 03.05.2018). The decision of NTA on unfair means will be final and no correspondence will be entertained in this regard.

mailto:[email protected]


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GUIDELINES TO CANDIDATES FOR COMPUTER BASED TEST

Candidates MUST bring the following documents on the day of examination at the test centre. Candidates who will not bring these will not be allowed to sit in the examination.

➢ Print copy of Admit Card downloaded from NTA’s website. ➢ One passport size photograph (same as uploaded on the Online Application Form) should

be taken for pasting on the specific space in the attendance sheet at Centre during GPAT Examination.

➢ Any one of the authorized photo IDs (must be original, valid and non-expired) – PAN card/ Driving License/ Voter ID/ Passport/ Aadhaar Card (With photograph)/ Ration Card

➢ PwD certificate issued by the authorized medical officer, if claiming the relaxation under PwD category

The candidates shall report at the Examination Centre two hours before the commencement of the examination so as to complete the frisking and registration formalities well before the time. Registration desk will be closed 60 minutes prior to the commencement of examination. Candidates shall not be permitted to enter in the Examination Center after 8:30 a.m. The candidates are advised to read the instructions on the admit card carefully and follow them during the conduct of the examination. The candidate must show, on demand, the Admit Card downloaded/printed from the NTA’s website for entry in the examination room/hall. A candidate who does not possess the valid Admit Card shall not be permitted for the examination under any circumstances by the Centre Superintendent. A seat indicating roll number will be allocated to each candidate. Candidates should find and sit on their allocated seat only. Any candidate found to have changed room/hall or the seat on his/her own other than allotted, his/her candidature shall be cancelled and no plea would be accepted for it. No candidate, without the special permission of the Centre Superintendent or the Invigilator concerned, will leave his/her seat or Examination Room/Hall until the full duration of the paper is over. Candidates must follow the instructions strictly as instructed by the Centre Superintendent/Invigilators. Candidates should not leave the room/hall without handing over their rough sheets to the invigilator on duty in the Room/Hall. Smoking, chewing gutka, spitting etc. in the Examination Room/Hall is strictly prohibited.


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For those who are unable to appear on the scheduled date of tests for any reason, the NTA shall not be responsible for conduct of re-test, under any circumstances.

WEEDING OUT RULES

The record of GPAT-2020 would be preserved upto 60 days from the date of declaration of result.

LEGAL JURISDICTION

All disputes pertaining to the conduct of GPAT-2020 Examination including Results shall fall within the jurisdiction of Delhi only.

The Sr. Director (Admin) of the NTA shall be the official by whose designation the NTA may sue or be sued.


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Appendix-I

Certificate regarding physical limitation in an examination to write

This is to certify that, I have examined Mr/Ms/Mrs ______________(name of the candidate with disability),

a person with____________(nature and percentage of disability), S/o\D/o ____________a resident of

_____________(Village/District/State) and to state that he/she has physical limitation which hampers

his/her writing capabilities owing to his/her disability.

Signature

Chief Medical Officer/ Civil Surgeon/ Medical Superintendent

Government health care institution

Name and Designation.

Name of Government Hospital/ Health Care Centre with Seal

Place:

Date:

NAME Name of ID Proof ID Number

Photograph

SIGNATURE OF THE CANDIDATE


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Appendix-II

Letter of Undertaking for Using Own Scribe

I _____________, a candidate with_____________ (name of the disability) appearing for the ___________(name of

the examination) bearing Application No. _________ at____________(name of the centre)in the District

__________,___________(name of the State). My qualification is ____________.

I do hereby state that_____________(name of the scribe) will provide the service of scribe/reader/lab assistant for the

undersigned for taking the aforesaid examination.

I do hereby undertake that his qualification is ______________. In case, subsequently it is found that his qualification

is not as declared by the undersigned and is beyond my qualification, I shall forfeit my right to the admission and claims

relating there to.

(Signature of the candidate with disability)

Place:

Date:

(Self-Attested Photograph)

NAME of Scribe ID of the Scribe ID Number

Photograph

of

Scribe


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APPENDIX - III

LIST OF EXAMINATION CITIES FOR GPAT-2020

GPAT-2020 will be conducted in the following cities, provided there are sufficient numbers of candidates in the city. State wise list of Cities in India for GPAT-2020:

STATE CITY City Code Proposed Candidate

capacity

ANDAMAN AND NICOBAR

PORT BLAIR AN01 70

ANDHRA PRADESH

GUNTUR AP07 1200

KURNOOL AP10 1200

NELLORE AP11 500

RAJAHMUNDRY AP13 1000

TIRUPATHI AP16 1200

VIJAYAWADA AP17 1500

VISAKHAPATNAM AP18 2500

ARUNACHAL PRADESH

ITANAGAR/NAHARLAGUN AL01 200

ASSAM ASSAM

DIBRUGARH AM01 700

GUWAHATI AM02 2000

BIHAR BIHAR

MUZAFFARPUR BR06 1200

PATNA BR07 5000

CHANDIGARH CHANDIGARH/MOHALI CH01 2200

CHHATTISGARH BHILAI NAGAR/DURG CG01 2500

RAIPUR CG03 1200

DELHI DELHI/NEW DELHI DL01 7500

GOA PANAJI/MADGAON GO01 175

GUJARAT

AHMEDABAD/GANDHINAGAR GJ01 4200

ANAND GJ02 1300

BHAVNAGAR GJ03 300

MEHSANA GJ08 700

RAJKOT GJ10 1800

SURAT GJ11 2000

VADODARA GJ12 2000

HARYANA

AMBALA HR01 1200

FARIDABAD HR03 1000

GURUGRAM HR04 2000

HISSAR HR05 600

HIMACHAL PRADESH

BILASPUR(HIMACHAL PRADESH) HP01 230

HAMIRPUR(HIMACHAL PRADESH) HP03 250

SHIMLA HP06 350

SOLAN HP07 200


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STATE CITY City Code Proposed Candidate capacity

JAMMU AND KASHMIR

JAMMU JK02 900

SRINAGAR (J & K) JK04 900

JHARKHAND

DHANBAD JH02 700

JAMSHEDPUR JH03 1000

RANCHI JH04 2800

KARNATAKA

BELAGAVI(BELGAUM) KK02 450

BENGALURU KK04 5000

GULBARGA KK08 450

DHARWAD/HUBBALLI(HUBLI) KK10 900

MANGALURU(MANGALORE) KK12 750

MYSURU(MYSORE) KK14 1000

UDUPI/MANIPAL KK17 220

KERALA

ERNAKULAM/ANGAMALY/MOOVATTUPUZHA

KL04 2200

KOTTAYAM KL11 800

KOZHIKODE KL12 700

THIRUVANANTHAPURAM KL17 1200

THRISSUR KL18 1200

LADAKH LEH LL01 50

LAKSHADWEEP KAVARATTI LD01 10

MADHYA PRADESH

BHOPAL MP03 4500

GWALIOR MP06 1500

INDORE MP07 5000

JABALPUR MP08 2000

SAGAR MP12 1200

MAHARASHTRA

AHMEDNAGAR MR01 450

AMRAVATI MR03 1200

AURANGABAD (MAHARASHTRA) MR04 2000

DHULE MR10 750

KOLHAPUR MR14 1600

MUMBAI/NAVI MUMBAI MR16 4800

NAGPUR MR17 4000

NANDED MR18 1000

NASHIK MR19 2000

PUNE MR22 7500

SOLAPUR MR27 1100

THANE MR28 900


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STATE CITY City Code Proposed Candidate capacity

MANIPUR IMPHAL MN01 550

MEGHALAYA SHILLONG MG01 300

MIZORAM AIZAWL MZ01 160

NAGALAND DIMAPUR NL01 100

KOHIMA NL02 150

ODISHA

BERHAMPUR-GANJAM OR03 450

BHUBANESWAR OR04 4000

SAMBALPUR OR09 450

PUDUCHERRY PUDUCHERRY PO01 80

PUNJAB PUNJAB PUNJAB

AMRITSAR PB01 700

BHATINDA PB02 1400

LUDHIANA PB05 700

RAJASTHAN

JAIPUR RJ06 7500

JODHPUR RJ07 1000

KOTA RJ08 1000

UDAIPUR RJ11 1200

SIKAR RJ09 750

TAMIL NADU

CHENNAI TN01 3500

COIMBATORE TN02 2000

MADURAI TN08 1000

TIRUCHIRAPPALLI TN14 1000

TIRUNELVELI TN15 1000

TELANGANA

HYDERABAD/SECUNDERABAD/RANGA REDDY

TL01 7500

KARIMNAGAR TL02 1000

WARANGAL TL07 850

TRIPURA AGARTALA TA01 500

UTTAR PRADESH

AGRA UP01 2500

ALLAHABAD/PRAYAGRAJ UP03 2500

BAREILLY UP04 1000

GHAZIABAD UP07 1500

GORAKHPUR UP08 1500

NOIDA/GREATER NOIDA UP09 3000

KANPUR UP11 2500

LUCKNOW UP12 3000

MEERUT UP14 1500

VARANASI UP18 2500

UTTARAKHAND DEHRADUN UK01 1000

ROORKEE UK06 1000

WEST BENGAL KOLKATA WB10 5000

SILIGURI WB11 1100


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Appendix – IV

SERVICE/PROCESSING CHARGES & GOODS & SERVICE TAX (GST) AND PROCEDURE FOR PAYMENT OF FEE

Mode of Payment of Fee and Service/Processing charges & GST After completing Step-3 of Online Application Form, candidates may remit the examination fee (Step -4) by choosing the following options:

i) Online Mode i.e., Debit/Credit Card, Net Banking, Unified Payment Interface (UPI) and PayTM Service in ICICI Bank or HDFC Bank or Syndicate Bank or State Bank of India

- Check the validity of the Debit/ Credit Card and keep it ready with you while logging on to website for submitting application form. Candidate should enter the information asked for and make payment through Debit/ Credit Card.

- Through Net Banking, check the balance in your account and keep all credentials ready with you while logging on to website for submitting application form. Candidate should Login with his/her credentials of net banking and make payment through Net Banking.

- Through UPI service - Through PayTM service.

ii) Please select any Mode of Payment/Service Provider (Service/Processing charges per transaction & GST (applicable @ 18 %) to be paid by the candidate):

S. No.

Mode of Payment

ICICI BANK HDFC BANK SYNDICATE BANK STATE BANK OF INDIA

PAYTM

1 Net Banking

ICICI NIL Charge HDFC NIL Charge Syndicate Bank

NIL Charge

SBI

Rs 5.00+GST

Rs 4 +GST Other Banks 4.00 + GST Other Banks 4.00 + GST Other Banks 5.00 + GST Other Banks

2 All Debit Card

ICICI or Other Banks

Transaction upto

Rs 2000/-

0 %

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(उच्चतर शिक्षा शिभाग, मानि संसाधन शिकास मंत्रालय, भारत सरकार के तहत एक स्वायत्त संगठन)

सार्वजनिक सचूिा

नििाांक : 31.10.2019 राष्ट्रीय परीक्षा एजेंसी (एनटीए) कंप्यूटर आधाररत परीक्षा (सीबीटी) मोड में शैक्षणिक वर्ष 2020-21 के लिए स्नातकोत्तर प्रबंधन प्रोग्राम और फामेसी प्रोग्राम में प्रवेश के लिए राष्ट्रीय स्तर की ननम्नलिणित परीक्षाओ का आयोजन करेगी:

परीक्षा

परीक्षा की नतथि

परीक्षा का समय

सामान्य प्रबंधन प्रवेश परीक्षा (CMAT-2020) मंगिवार, 28 जनवरी, 2020

09:30 पूवाषन्ह से 12.30 अपरान्ह तक

स्नातक फामेसी अलिरुथि परीक्षा (GPAT-2020) मंगिवार, 28 जनवरी, 2020

02:30 अपरान्ह स े05.30 सायं तक

जो उम्मीदवार परीक्षा में शालमि होने की इच्छा रिते हैं, वे एनटीए की वेबसाइटों www.nta.ac.in, cmat.nta.nic.in (CMAT-

2020 के लिए) और gpat.nta.nic.in (GPAT-2020 के लिए) पर उपिब्ध ववस्ततृ सूिना बुिेटटन देि सकते हैं और 1 नवंबर, 2019

से 30 नवंबर 2019 के बीि ऑनिाइन आवेदन कर सकते हैं । आवेदन शुल्क का िुगतान 1 टदसंबर 2019 (11:50 रात्रि) तक ककया जा सकता है।

कंप्यूटर आधाररत परीक्षा (सीबीटी) के परीक्षा कें द्र के लिए शहर परीक्षा शुल्क जमा करने के बाद आवेदकों द्वारा (पहिे आओ - पहि ेपाओ के आधार पर) स्वयं िुना जाएगा। वववरि के लिए, कृपया सूिना बुिेटटन देिें।

CMAT और GPAT के लिए अनुमोटदत संस्िानों में प्रवेश के इच्छुक अभ्यथिषयों को वांनछत CMAT-2020 स्कोर एवं GPAT-2020 स्कोर के साि अिग-अिग आवेदन करना िाटहए ।

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वरिष्ठ निदशेक, एिटीए

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(उच्चतर शिक्षा शिभाग, मानि संसाधन शिकास मंत्रालय, भारत सरकार के तहत एक स्वायत्त संगठन) (An autonomous organization under the Department of Higher Education,

Ministry of Human Resource Development, Government of India)

PUBLIC NOTICE Dated:31.10.2019

The National Testing Agency (NTA) will conduct the following National Level Tests for admissions to Post Graduate Management Programs and Pharmacy Programs for the Academic Year 2020-21 in Computer Based Test (CBT) mode:

Examination

Date of Examination

Timings of Examination

Common Management Admission Test 2020 (CMAT-2020)

Tuesday, January 28, 2020 09:30 a. m. to 12.30 p.m.

Graduate Pharmacy Aptitude Test 2020 (GPAT-2020)

Tuesday, January 28, 2020 02:30 p.m. to 05.30 p.m.

Candidates who desire to appear in the above Tests may see the detailed Information Bulletin available on the NTA’s websites viz.www.nta.ac.in, cmat.nta.nic.in for CMAT 2020 and gpat.nta.nic.in for GPAT-2020 and apply Online between 1st November, 2019 to 30th November 2019. The application fee can be paid upto 1st December 2019(11:50 p.m.).

The city for computer based test (CBT) mode will be chosen by the applicants themselves after the submission of examination fees on first come-first served basis. For details, please see the Information Bulletin.

Candidates must apply separately to the desired CMAT-2020 and GPAT-2020 participating institutes with the CMAT score 2020 and GPAT score 2020.

The Information Bulletin containing detailed information of the Test, eligibility criteria to appear, examination fees, Cities of the examination are available on the website cmat.nta.nic.in/ gpat.nta.nic.in. Candidates may, therefore check all the details in the Information Bulletin before submission of Application Form.

Senior Director, NTA

CONTACT DETIALS

website: cmat.nta.nic.in, gpat.nta.nic.in Email: [email protected]/[email protected] Call Centre Numbers- 0120-6895200

COMMON MANAGEMENT ADMISSION TEST 2020 (CMAT 2020) AND GRADUATE PHARMACY APTITUDE TEST 2020 (GPAT 2020)



http://www.ntacmat.nic.in/ntagpat.nic.in

http://www.ntacmat.nic.in/ntagpat.nic.in



mailto:[email protected]/[email protected]

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Syllabus

GPAT - 2018

ALL INDIA COUNCIL FOR TECHNICAL EDUCATION Nelson Mandela Marg, Vadsant Kunj,

New Delhi-110 070

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PHYSICAL CHEMISTRY

1. Composition & physical states of matter

Intermolecular forces & their impact on the state of the matter. Various physical properties of

matter, dipole moment, dielectric constant, Van Der Waal's equation & critical phenomenon,

liquefaction of gases, aerosols.

2. Colligative Properties

The liquid state, vapor pressure, ideal & real solutions. Raoult's law, elevation of boiling point,

depression of freezing point, osmotic pressure, determination of molecular weight based on

colligative properties.

3. Thermodynamics

First, second & third law of thermodynamics. Thermochemical laws, isothermic & adiabatic

processes, reversible processes, work of expansion, heat content, enthalpy, heat capacity.

Gibb's & Helmholtz equation & chemical potential.

4. Refractive index

Refractive index, specific refractivity, molar refractivity, refractometers.

5. Solutions

Solubility, factors affecting solubility, solubility curves. Types of solutions, effect of co-solvency,

pH & other factors on solubility. Solubility of gases in liquids, liquids in liquids, & solids in

liquids, critical solution temperature, law of partitioning & its applications. Solute-solvent

interactions. Expression of the concentration of pharmaceutical solutions & calculations.

Molarity, molality, mole fraction & percentage expressions.

6. Electrochemistry

Properties of electrolyte solutions, electrolysis. Faraday's law of electrolysis, electron transport,

electrical cell, single electrode potential, concentration cells, half-cells & half-cell potential,

types of half cells, sign convention, Nernst equation, salt bridge, electromotive series, standard

potential, SHE. Measuring the relative voltage of half cells, Calculation of standard potential.

Reference & indicator electrodes. Standard oxidation-reduction potential.

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7. Ionic equilibrium

Theory of conductivity, equivalent conductance, mobility of ions, specific conductance.

8. Kinetics

Order of reactions, derivation & internal form of rate laws, molarities of reaction,

derivation of rate constants.

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PHYSICAL PHARMACY

1. Matter, properties of matter

States of matter, change in the state of matter, latent heat and vapor pressure, sublimation-

critical point, eutectic mixtures, gases, aerosols- inhalers, relative humidity, liquid complexes,

liquid crystals, glasses state, solid crystalline and amorphous polymorphism.

2. Micromeritics and powder rheology

Particle size and distribution, average particle size number and weight distribution, particle

number, methods of determining particle size and volume, optical microscopy, sieving,

sedimentation, determining surface areas, permeability, adsorption, derived properties of

powders, porosity, packing arrangement densities, bulkiness and flow properties.

3. Surface and interfacial phenomenon

Liquid interface, surface and interfacial tensions, surface free energy, measurement of surface

and interfacial tension, spreading coefficient, adsorption and liquid interfaces, surface active

agents, HLB classification, solubilization, detergency, absorption at solid interfaces, solid gas

and solid-liquid interfaces, complex films, electrical properties of interfaces.

4. Viscosity and rheology

Newtonian systems, law of flow, kinematics viscosity, effect of temperature, non- Newtonian

systems, pseudoplastics, dilatant, plastic, thixotropy in formulations, determination of viscosity

and thixotropy by capillary, falling ball, rotational viscometer, application of theology in

pharmacy

5. Dispersion systems

a. Colloidal dispersions: Definition, types, properties of colloids, protective

colloids, application of colloids in pharmacy.

b. Suspensions and emulsions: Interfacial properties of suspended particles

settling in suspension, theory of sedimentation, effect of Brownian movement,

sedimentation of flocculated particles, sedimentation parameters, wetting of

particles, significance of electrical properties in dispersions, controlled

flocculation, flocculation in structured vehicles, rheological considerations,

emulsions: types, theories, physical stability.

6. Complexation

Classification of complexes, methods of preparations and analysis, applications.

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7. Buffer

Buffer equations and buffer capacity in general. Buffers in pharmaceutical systems,

preparations and stability, buffered isotonic solutions. Measurements of tonicity calculations

and methods of adjusting isotonicity.

8. Solubility

a. Miscibility-influence of foreign substances

three component systems;

dielectric constant and solubility,

solubility of solids in liquids

ideal and non-ideal solutions

solvation and association in solutions

solubility of salts in water

solubility of slightly soluble and weak electrolyte

calculating solubility of weak electrolytes as influenced by pH, influence of solvents on the

solubility of drugs

combined effect of pH and solvents, distribution of solutes between immiscible solvents,

effect of ionic dissociation and molecular association on partition, extraction,

preservatives action of weak acids in emulsions, drug action and distribution coefficient.

b. Concepts of dissolution and diffusion.

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ORGANIC CHEMISTRY

1. General principles

A brief review of classification & sources of organic compounds, sp3, sp

2, sp hybridization,

sigma & pi- bonds, bond lengths, bond angles & bond energies along with their significance in

reactions should be carried out. An overview of bond polarization, hydrogen bonds, inductive

effects, resonance, and hyperconjugation be taken. Concept of homolytic & heterolytic bond

fission, acidity & basicity with different theories should be covered briefly. Ease of formation

& order of stabilities of electron deficient & electron rich species along with the reasons for

the same should be covered. Relationships between energy content, stability, reactivity &

their importance in chemical reactions should be covered. Calculations for determining

empirical & molecular formula should be covered.

2. Different classes of compounds

The following classes of compounds should be taught in detail with respect to their IUPAC /

systematic nomenclature, industrial [wherever applicable] & laboratory methods of

preparations, physical properties & chemical reactions with emphasis on reaction

mechanisms [arrow based] & stereochemistry [wherever applicable].

• Alkanes [including cyclic compounds]

• Alkenes [including cyclic compounds]

• Alkynes [only open-chain compounds]

• Aliphatic hydroxyl compounds

• Alkyl halides

• Aldehydes & Ketones

• Carboxylic acids

• All functional derivatives of carboxylic acids.

3. Protection & deprotection of groups

Introduction to protection & deprotection of functional groups. Two examples each for amino,

hydroxyl, & carbonyl groups. The significance of these in syntheses should be explained.

4. Aromaticity & chemistry of aromatic compounds

Concept of aromaticity, Huckel's rule & its use in determining the aromatic/non-aromatic

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character of a compound. A brief coverage of structure of benzene. Detailed coverage of

electrophilic & nucleophilic aromatic substitution reactions. Reactivity & orientation in these

reactions. Reactivity & orientation in mono- & disubstituted benzenes. Benzyne mechanism.

5. Different aromatic classes of compounds

The following classes of compounds with respect to their IUPAC / systematic nomenclature,

industrial [wherever applicable] & laboratory methods of preparations,

physical properties & chemical reactions with emphasis on reaction mechanisms [arrow based]

& stereochemistry [wherever applicable].

Aromatic hydrocarbons.

Phenolic compounds.

Aromatic & aliphatic amines.

Diazonium salts.

Aromatic nitro- compounds, aryl halides, & ethers.

6. Polycyclic aromatic hydrocarbons

Syntheses & reactions with mechanisms of bi & tricyclic fused carbocyclic rings like

naphthalene, anthracene, & phenanthrene.

7. Carbonyl Chemistry

Carbonyl chemistry involving group conversions & their reaction mechanisms along with

stereochemistry wherever applicable.

a. Wolf-Kishner reduction & Huang-Minlong modification.

b. Reduction of arylsulfonyl hydrazine/hydrazones to alkanes.

c. Bamford Steven reaction.

d. DCC Oxidation of alcohol.

e. Michael addition / 1,4-addition / conjugate addition.

f. Mannich condensation / reaction.

g. Robinson annulation.

h. Stobbe condensation.

i. Darzen's glycidic ester synthesis.

j. Beckmann rearrangement.

k. Baeyer Villiger rearrangement.

l. Curtius, Wolff, & Lossen rearrangements.

m. Willgerodt rearrangement.

n. Pinacol-pinacolone rearrangement.

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o. Methylene transfer reactions. Use of diazomethane & sulphur ylides in the same.

p. Mono- & dialkylations in 1,3-dicarbonyl compounds.

q. Formation & use of enol ethers, enol acetates & enamines as protective groups & in

regiospecific alkylations.

8. Heterocyclic Chemistry

IUPAC Nomenclature of heterocyclic rings [3-10 membered] containing O, S, & N atoms.

Nomenclature of above rings containing mono-, di-, & multiple [same or different] heteroatoms

should also be covered. Nomenclature of 2 & 3 fused rings containing mono-, di-, & multiple

heteroatoms [same or different] should also be covered. Syntheses & reactions of three to six-

membered rings in detail. Syntheses of five & six-membered rings containing mono- or any di-

heteroatoms [O, S, & N]. Syntheses of quinoline, isoquinoline, benzoxazole, benzothiazole, &

benzimidazole, benzotriazole, and benzothiazole.

9. Bridged rings

Bridged ring systems & their nomenclature.C8, C9, C11 bridged bicyclic alkanes. Chemistry of

hexamine, morphan, biperiden, amantadine, diazabicyclo[2.2.2] octane

10. Kinetic & thermodynamic control

Kinetic & thermodynamic control of sulfonation, enolate anion formation & alkylation of

enamine reactions.

11. Stereochemistry

Stereochemistry. Chirality & asymmetry [introduction of the same to S, P, & N]. Definition &

classification [different types of isomerisms]. Enantiomers, diastereomers. Enantiomerism &

diastereomerism. Meso compounds & their optical activity. Stereochemistry in acyclic

compounds. Newman projection formulae & their significance. Conformational analysis of n-

butane. Absolute & relative configuration. Assigning R & S configuration based on Cahn Ingold

& Prelog system. Racemic mixture- its definition & resolution. Definitions of terms

stereoselective, stereospecific, Enantiomeric excess & diastereomeric excess. Stereochemistry

in cyclic systems. Conformations of cyclohexane. Cis-trans relationship in cyclohexane.

Prediction of stability of different conformations of 1, 2- 1,3- & 1,4- disubstituted cyclohexanes.

Effect of multiple substitutions on the stability of cyclohexane conformations. Chair

conformations of cis-, & trans-decalins, perhydrophenanthrenes, & a tetracyclic steroidal

nucleus. An introduction to atropisomerism.

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12. Carbohydrates

Carbohydrates. Definition & classification. D & L nomenclature in sugars. Different ways of

drawing / representing a sugar molecule [including cyclic Structure], interconversion of these

representations. Anomers & epimers. Mutarotation. Reactions of glucose. Chain extension &

chain reduction of a sugar.

13. Amino acids & proteins

Amino acids & proteins. Definition & classification. D & L Amino acids, natural, essential, & non-

essential amino acids. Denaturation, Strecker, Gabriel phthalimide methods for the preparation

of amino acids. Peptide bond & its formation. Two protective groups each, for -NH2 & -COOH

functionalities during protein synthesis. Sequencing of a protein by chemical & enzymatic

methods.

14. Pericyclic reactions

Pericyclic reactions. Concept of HOMO & LUMO. Drawing of HOMO & LUMO of 1, 3-butadiene,

allylic cation, radical & anion, & 1, 3, 5-hexatriene, Diel's-Alder & retro Diel's Alder reaction.

of 54

PHARMACEUTICAL CHEMISTRY

I. Pharmaceutical Inorganic Chemistry

1. Pharmaceutical Impurities

Impurities in pharmaceutical substances, sources, types & effects of impurities. Limit tests for

heavy metals like lead, iron, arsenic, mercury & for chloride & sulphate as per Indian

Pharmacopoeia [I. P.].

2. Monographs

(a) Monograph & its importance, various tests included in monographs as per I. P. A study

of the following compounds with respect to their methods of preparation, assay, &

pharmaceutical uses of sodium citrate, calcium carbonate, copper sulphate, light &

heavy kaolin, ammonium chloride & ferrous gluconate.

3. Isotopes

Isotopes- stable & radioactive, mode & rate of decay. Types & measurement of radioactivity.

Radiopharmaceuticals & their diagnostic & therapeutic applications in pharmacy & medicine

such as 125

I, 32

P, 51

Cr, 60

Co, 59

Fe, 99

Tc-M. Radiocontrast media, use of BaSO4 in medicine.

4. Dentifrices, desensitizing agents, & anticaries agents

II. Medicinal Chemistry

5. Therapeutic classes of drugs

The following topics should be dealt with covering nomenclature [including stereochemical

aspects], biological activity [including side & toxic effects], mode of action, structure-activity

relationship [where ever applicable] & syntheses of reasonable molecules.

1. General anesthetics.

2. Local anesthetics.

3. Diagnostic agents.

4. Coagulants, anticoagulants & plasma expanders.

5. Antiseptics, disinfectants, sterilants, & astringents.

6. Purgatives, laxatives & antidiarrhoeal agents.

6. Various classes of therapeutic agents

A detailed study of the following classes with respect to drug nomenclature, classification,

physicochemical properties, mode of action [MOA], structure-activity relationships [SAR],

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wherever applicable, synthesis of simple & prototype molecules, drug metabolism, therapeutic

uses & side effects. Drug resistance, wherever applicable, should be covered in respective

classes of drugs.

a. Antimalarials

b. Antiamoebic agents.

c. Anthelmintic agents.

d. Antibacterial sulpha drugs [only].

e. Quinolone antibacterials.

f. Antimycobacterial drugs.

g. Antifungal agents.

g. Antiviral agents including HIV & anti-HIV drugs.

h. Thyroid & antithyroid drugs.

i. Antiallergic agents.

j. Antiulcer agents & Proton Pump Inhibitors.

k. Hypoglycemic agents.

7. Different classes of therapeutic drugs


physicochemical properties, mode of action [MOA], structure-activity relationships [SAR],

wherever applicable, synthesis of simple & prototype molecules, drug metabolism, therapeutic

uses & side effects. Drug resistance, wherever applicable, should be covered in respective

classes of drugs.

I. a. Sedative-hypnotics

b. Antiepileptic agents.

c. Neuroleptics.

d. Anti-anxiety drugs.

II. Antibiotics. Penicillins, cephalosporins & other beta-lactam antibiotics like imipenem &

aztreonam. Beta-lactamase inhibitors such as clavulanic acid & sulbactam.

Chloramphenicol. Tetracyclines. Aminoglycoside antibiotics. Macrolide antibiotics.

Lincomycins. Polypeptide antibiotics. Anticancer antibiotics.

III. Steroids. Corticosteroids [gluco- & mineralocorticoids] & anti-inflammatory steroids. Sex

steroids. Male & female contraceptive agents. Anabolic steroids.

Anticancer agents.

8. Different classes of therapeutic drugs


physicochemical properties, mode of action [MOA], biosynthesis, structure-activity

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relationships [SAR], wherever applicable, synthesis of simple & prototype molecules, drug

metabolism, therapeutic uses & side effects. Drug resistance, wherever applicable, in respective

classes of drugs.

I. Narcotic [centrally acting] analgesics [analgetics]. Morphine & all its structural

modifications [peripheral & nuclear]. Narcotic agonists & antagonists [dual & pure].

Non-narcotic analgesics [NSAIDS]. Difference between narcotic & non-narcotic agents.

II. Adrenergic drugs. Neurotransmitters & their role. General & specific adrenergic agonists

& antagonists [up to alpha-2 & beta-2 only].

III. Cholinergic agents. Muscarinic & nicotinic cholinergic agonists & antagonists [up to M2

& N2]. Neuronal [transmission] blockers.

IV. Drugs used in neuromuscular disorders. Drugs used in the treatment of

Parkinson's disease. Central & peripheral muscle relaxants.

V. Hypertensive, antihypertensive, & antianginal agents.

VI. Diuretics.

VII. Eicosanoids. Prostaglandins, prostacyclins, & thromboxanes. Their biochemical

role, biosynthesis, & inhibitors.

9. Introduction to quantitative structure-activity relationship. [QSAR]. Linear free energy

relationship. Hammett's equation. Use of substituent constants such as π,

σ, Es, & physicochemical parameters such as pKa, partition coefficient, Rm, chemical shifts,

molar refractivity, simple & valance molecular connectivity to indicate electronic effects,

lipophilic effects, & steric effects. Introduction, methodology, advantages &

disadvantages/limitations of Hansch analysis.

10. Asymmetric synthesis. Chirality, chiral pool, sources of various naturally available chiral

compounds. Eutomers, distomers, eudismic ratio. Enantioselectivity &

enantiospecificity. Enantiomeric & diastereomeric excess. Prochiral molecules.

Asymmetric synthesis of captopril & propranolol.

11. Combinatorial chemistry. Introduction & basic terminology. Databases & libraries. Solid

phase synthesis technique. Types of supports & linkers, Wang, Rink, & dihydropyran

derivatized linkers. Reactions involving these linkers. Manual parallel & automated

parallel synthesis. Houghton's tea bag method, micromanipulation, recursive

deconvolution. Mix & split method for the synthesis of tripeptides. Limitations of

combinatorial synthesis. Introduction to throughput screening.

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PHARMACEUTICS

1. Pharmacy Profession & Introduction to Pharmaceuticals

Pharmacy as a career, evaluation of Pharmacy, earlier period middle to modern ages.

Definition, importance of pharmaceuticals, areas concerned, scope of Pharmaceutics, history

and development of the profession of Pharmacy and Pharmaceutical industry in India. A brief

review of present Indian Pharma. Industry in global perspective.

2. Introduction to dosage form

Definition of the drug. New drug and dosage form. The desirable properties of a dosage form,

the need of dosage form. Ideas about the available type of dosage forms and new drug delivery

system.

3. Sources of drug information

Introduction to Pharmacopoeia with reference to IP, BP, USP and International Pharmacopeia.

Study of structure/features (index) general notice and compartment of monographs of

excipients, drug and drug product. Other sources. Textbooks, journals, internet (drug

information system, online database, patient/ consumer information and non- print material.

Classification of information, primary, secondary and tertiary. Nomenclature of the drug.

4. Allopathic dosage form

Merits/demerits, importance, formulation development - vehicles/excipients with examples for

the dosage form: liquid dosage form: monophasic liquid dosage form. Aromatic waters, syrup,

elixir, linctus, lotion, liniment, glycerites, solutions, spirits, ENT preparations, mixtures, paints,

mouthwash.

5. Crude extract

Infusion, decoction, maceration, percolation, tincture and extract. Methods of preparations of

dry, soft and liquid extract.

6. Allergenic extract

Types of allergens, preparation of extract, testing and standardization of extracts.

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7. Biological products

Absorbable and non-absorbable material types, sutures and ligatures, processing,

manufacturing, sterilization, packing, QC tests of materials like catgut and nylon.

8. Pharmaceutical Plant, location, layout

Plant location and layout of an industry. Various factors affecting locational aspects of chemical

and pharmaceutical plants. The layout of plant building and importance of flow sheet, the

difference between scientific process and technological process, the layout of various

departments, equipment, and product layout v/s process layout.

9. Dosage Form Necessities and Additives

Antioxidants, preservatives, coloring agents, flavoring agents and diluting agents, emulsifying

agents, suspending agents, ointment bases, solvents, and others.

10. Powders

Advantages and limitations as dosage form, manufacturing procedure and equipment, special

care and problems in manufacturing powders, powders of IP, effervescent granules and salts.

11. Capsules

Hard gelatin capsules, shell formulation and manufacturing, capsule sizes, storage, filing,

cleaning process general formulation contents and evaluation. Soft gelatin capsules, shell

formulation, formulation contents, filing, sealing and storage. Microencapsulation, advantages,

encapsulation materials, methods of microencapsulation, I.P. formulations

12. Tablets

Types, ideal requirement, classification, granulation methods, general formulation,

compression machines, different types of tooling’s, difficulties in tableting, troubleshooting

aspects, evaluation, sugar coating, compression coating, film coating, problems in tablet

coatings and their troubleshooting aspects. IP formulations.

13. Parenterals - product requiring sterile packaging

Definition, types advantages and limitations, general formulation, vehicles, production

procedure, production facilities, controls, tests, selected IP injections, sterile powders, implants,

emulsions, suspensions.

14. Suspensions

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Formulation of deflocculated and flocculated suspension, manufacturing procedure, evaluation

methods, IP suspensions.

15. Emulsions

Types, emulsifying agents, general formulation, manufacturing procedure, evaluation methods,

IP emulsions.

16. Suppositories

Ideal requirements, bases, manufacturing procedure, evaluation methods, IP products.

17. Semisolids

Definitions, bases, general formulation, manufacturing procedure, evaluation methods, IP

products.

18. Liquids (solutions, syrups, elixirs, spirits, aromatic water, liquid for external uses)

Definition, types, general formulation, manufacturing procedure, evaluation methods, IP

products.

19. Pharmaceutical Aerosols

Definition, propellants, general formulation, manufacturing and packaging methods,

pharmaceutical applications. Impacts of propellants on the environment.

20. Ophthalmic preparations

Requirement, formulation, methods of preparation, containers, evaluation, IP products.

21. Preformulations

Consideration of Importance, physical properties, physical forms, particle size, crystal forms,

bulk control, solubility, wetting, flow cohesiveness, compressibility, organoleptic properties and

its effect on final product consideration of Chemical properties, hydrolysis, oxidation,

recemization, polymerization, isomerization, decarboxylation, enzymatic decomposition,

formulation additives, stabilizers, suspending and dispersing agents dyes, solid excipients etc.

and its effect on quality of finished product.

22. Stability of formulated products

Requirements, drug regulatory aspects, pharmaceutical products stability, shelf life, overages,

containers, closures.

Reaction rate and order, acid-base catalysis, destabilization and accelerated stability testing.

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23. Prolonged Action Pharmaceuticals

Benefits, limitations, oral products, terminology, drug elimination rate, types and construction

of implants products, product evaluation, parenteral products, absorption and evaluation.

24. Novel Drug delivery system

Critical fluid technology, transdermal drug delivery system, controlled drug delivery system,

multiple emulsion, nanoparticles, targeted drug delivery system, aerosols, inhalation & new

products reported etc.

25. GMP and Validation

Introduction to GMP, QC and QA. Concept and need of good manufacturing practice guidelines.

Elements of GMP covering controls of area and processes and product. Regulations related to

GMP. Introduction of the validation process. Types of validation. The brief methodology of

process, equipment and instrument validation.

26. Packaging Materials

Role and features of Pharmaceutical packing materials. Glass, plastic, rubber, metal and paper

as pharmaceutical packaging material. General quality control of pharmaceutical packages.

Primary, secondary and tertiary packaging materials. Child resistant and pilfer-proof packaging.

27. Cosmetics

Formulation and preparation of dentifrices, hair creams, lipsticks, face powders, shaving

preparations, skin creams, shampoos, hair dyes, depilatories, manicure preparations etc.

28. Pilot plant scale-up techniques

Need, organization and layout, scale-up techniques for solid and liquid dosage forms.

Technology transfer.

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PHARMACOLOGY

1. General Pharmacology

Introduction to Pharmacology- Definition, scope and source of drugs, dosage forms and routes

of drug administration. Pharmacodynamics-Mechanism of drug action, Receptors,

classification and drug-receptor interactions, combined effects of drugs, factors modifying

drug actions.

Pharmacokinetics-Mechanism and principle of absorption, distribution, metabolism and

excretion of drugs. Principles of basic and clinical pharmacokinetics. Pharmacogenetics.

Adverse drug reactions.

Discovery and development of new drugs-Preclinical and clinical studies.

Detailed pharmacology including classification, mechanism of action and therapeutic uses

of following classes:

2. Nerohumoral transmission in autonomic and central nervous system:

Neurohumoral transmission (Autonomic and somatic). Neurohumoral transmission in the

C.N.S with special emphasis on Pharmacology of various neurotransmitters. Nitric oxide:

Biosynthesis of nitric oxide and its physiological role.

Therapeutic use of nitric oxide and nitric oxide donors. Clinical condition in which nitric

oxide may play a part.

Peptides and proteins as mediators:

General Principal of peptide pharmacology Biosynthesis and regulation of peptides Peptide

antagonists. Protein and peptide as drugs.

3. Pharmacology of peripheral nervous system

Parasympathomimetics, Parasympatholytics, Sympathomimetics, Sympatholytics,

Ganglionic stimulants and blockers. Neuromuscular blocking agents and skeletal muscle

relaxants (peripheral).

Local anesthetic agents. Drugs used in Myasthenia Gravis.

4. Pharmacology of central nervous System

General anesthetics. Alcohols and disulfiram. Sedatives, hypnotics and centrally acting

muscle relaxants, Psychopharmacological agents: Antipsychotics, antidepressants, antianxiety

agents, anti-manics and hallucinogens.

Anti-epileptic drugs. Anti-parkinsonism drugs. Nootropics.

Narcotic analgesics, drug addiction, drug abuse, tolerance and dependence.

5. Pharmacology of cardiovascular system

Introduction of hemodynamics and Electrophysiology of heart.

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Anti-hypertensive drugs, Anti-anginal agents, Anti-arrhythmic drugs.

Drugs used in congestive heart failure. Anti-hyperlipidemic drugs. Drugs

used in the therapy of shock.

Haematinics, anticoagulants and haemostatic agents.

Fibrinolytics and antiplatelet drugs.

Blood and plasma volume expanders.

6. Drugs acting on urinary system

Diuretics and anti-diuretics.

7. Drugs acting on Respiratory system

Anti-asthmatic drugs, Mucolytics and nasal decongestants, Anti-tussives and expectorants.

Respiratory stimulants

8. Pharmacology of Endocrine system

Basic concepts in endocrine pharmacology. Hypothalamic and pituitary hormones. Thyroid

hormones and antithyroid drugs, Parathormone, Calcitonin and vitamin-D. Insulin, oral

hypoglycemic agents and glucagon. ACTH and corticosteroids. Androgens and anabolic

steroids. Estrogens, progesterone and oral contraceptives. Drugs acting on the uteru.

9. Chemotherapy

General principles of chemotherapy. Sulphonamides and co-trimoxazole.

Antibiotics- Penicillins, cephalosporins, chloramphenicol, Macrolides, quinolones and

fluoroquinolons,. Tetracyclines. Aminoglycosides and miscellaneous antibiotics.

Chemotherapy of tuberculosis, leprosy, fungal diseases, viral diseases, AIDS, protozoal

diseases, worm infections, urinary tract infections and sexually transmitted diseases.

Chemotherapy of malignancy.

10. Autacoids and their Antagonists

Histamine, 5-HT and their agonsists and antagonists.

Prostaglandins, thromboxanes and leukotrienes. pentagastrin, cholecystokinin, angiotensin,

bradykinin and substance P.,Analgesic, anti-pyretic, anti-inflammatory and anti-gout drugs.

11. Pharmacology of drug acting on the gastrointestinal tract

Antacids, anti-secretary and antiulcer drugs.

Laxatives and antidiarrheal drugs. Appetite stimulants and suppressants. Digestants and

carminatives. Emetics and anti-emetics.

12. Chronopharmacology

Definition of rhythm and cycles. Biological clocks and their significance leading to

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chronotherapy.

13. Immnopharmacology

Immunostimulants and immunosuppressants.

14. Vitamins & Minerals

Vitamin deficiency diseases and their management. Role of minerals in health & diseases.

15. Principles of toxicology

Definition of poison. General principles of treatment of Poisoning. Treatment of poisoning

due to Heavy metals, insecticides, opioids and other addict forming drugs. Study of acute,

sub acute and chronic toxicity as per OECD guidelines (guidelines

420,423,425,407,408,451/452; only names and significance, detailed procedures and

minute details are not expected).

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PHARMACOGNOSY

1. Introductory Pharmacognosy

Historical development, modern concept and scope of Pharmacognosy. The significance of

Pharmacognosy in various systems of medicine practiced in India viz: Ayurveda, Unani,

Homeopathic and Siddha.

2. Classification of crude drugs

Based on alphabetical, morphological, pharmacological, chemical, taxonomical and

chemotaxonomic methods: organized and unorganized drugs: official and unofficial drugs.

Plants, animals and minerals: marine products: plant tissue culture.

3. Factors influencing quality of crude drugs

Exogenous factors: temperature, rainfall, daylight, altitude and soil. Endogenous factors:

Mutation, polyploidy, & hybridization in medicinal plants. Production factors including

collection, drying, storage and transport methods.

Study of morphological and histological characters of crude drugs, Ergastic cell inclusions,

anatomical structures of both monocot and dicot stems, leaves and roots: barks, fruits and

seeds.

4. Techniques in microscopy

Details of mountants, clearing agents, chemomicroscopic (microchemical) reagents.

5. Introduction to phytoconstituents

Definition, classification, chemical tests and pharmaceutical importance of: carbohydrates and

their derivatives, fats and proteins, alkaloids, glycosides, flavonoids, steroids, saponins, tannins,

resins, lipids and volatile oils.

6. Principles of plant classification

Diagnostic features and medicinal significance of important plants with special reference to:

Algae: Rhodophyceae (Agar, Alginic acid, Diatoms).

Fungi: Ergot, Yeast and penicillium.

Gymnosperm: Pinaceae (Turpentine, Colophony), Gnetaceae (Ephedra).

Angiosperm: Apocynaceae, Asteraceae, Lamiaceae, Rubiaceae, Rutaceae, Solanaceae,

Scrophulariaceae, Leguminosae, Papaveraceae, Acanthaceae and Apiaceae.

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Pteridophytes: Male fern.

7. Pharmaceutical aids

Biological sources, chemical constituents, adulterants and uses of: Starches, acacia gum,

tragacanth, sterculia, guar gum, pectin, arachis oil, castor oil, sesame oil, cottonseed oil, olive

oil, cotton, silk, wool, regenerated fibers, asbestos, kaolin, prepared chalk, kieselguhr.

8. Animal products

Biological sources, chemical constituents, adulterants and uses of: Shellac, cochineal,

cantharides, woolfat, lard, beeswax, honey, musk, lanolin, gelatin.

9. Plant products

Introduction to plant bitters, sweeteners, nutraceuticals, cosmeceuticals and photosensitizing

agents.

10. Toxic drugs

Study of allergens, hallucinogens, narcotics.

11. Enzymes

Biological sources, preparation, characters, and uses of: diastase, papain bromelain, ficin, yeast,

pancreatin, urokinase, pepsin, trypsin, penicillinase, hyaluronidase and streptokinase.

12. Natural pesticides and insecticides

Introduction to herbicides, fungicides, fumigants and rodenticides tobacco, pyrethrum, &

neem.

13. Adulteration and evaluation of crude drugs

Different methods of adulteration: Evaluation of drugs by organoleptic, microscopic, physical,

chemical and biological methods. Deterioration of herbal drugs by insects.

14. Quantitative microscopy

Definition and determination of stomatal index, stomatal number, palisade ratio, vein islet

number, vein termination number, lycopodium spore method. Micrometers and measurement

of microscopic characters.

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15. Biogenetic pathways

Formation of primary and secondary metabolites. Study of Calvin cycle, TCA cycle, Shikimic acid

pathway, Embden-Mayerhoff pathway, acetate hypothesis, isoprenoid pathway. Biosynthesis of

carbohydrates, lipids and volatile oils.

16. Carbohydrates & lipids

Biological sources, salient morphological features, chemical constituents, and uses of: Plantago,

bael, chaulmoogra oil, neem oil, shark liver oil, cod liver oil, guggul lipids.

17. Tannins

Biological sources, morphology, chemical constituents, chemical test and uses of: Pale catechu,

black catechu, nutgalls, Terminalia belerica, Terminalia chebula, Terminalia arjuna.

18. Volatile oils

Biological sources, morphology, chemical constituents, adulterants and uses of: Black pepper,

turpentine, mentha, coriander, cardamom, cinnamon, cassia, lemon peel, orange peel,

lemongrass, citronella, cumin, caraway, dill, spearmint, clove, anise, star anise, fennel, nutmeg,

eucalyptus, chenopodium, ajowan, sandalwood.

19. Resinous drugs

Classification, formation, sources, chemical constituents, identification test, adulterants and

uses of: benzoin, Peru balsam, tolu balsam, colophony, myrrh, asafoetida, jalap, colocynth,

ginger, turmeric, capsicum, cannabis, podophyllum.

20. Glycosides

Nature and classification. Biological sources, morphology, chemical constituents, adulterants

and uses of: Digitalis, strophanthus, squill, thevetia, oleander, cascara, aloe, rhubarb, senna,

quassia, dioscorea, quillaia, glycyrrhiza, ginseng, gentian, wild cherry, withania, bitter almond.

Biosynthesis of cardiac and anthraquinone glycosides.

21. Alkaloids

Nature, classification, biological sources, morphology, chemical constituents, adulterants and

uses of: Areca nut, belladonna, hyoscymous, stramonium, duboisea, coca, coffee, tea,

cinchona, opium, ipecac, nux vomica, ergot, rauwolfia, vinca, kurchi, ephedra, colchicum,

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vasaca, pilocarpus, aconite, Solanum xanthocarpum. Biosynthesis of tropane, cinchona and

opium alkaloids.

22. Extraction and Isolation Techniques

General methods used for the extraction, isolation and identification of alkaloids, lipids,

glycosides, flavonoids, saponins, volatile oils and resins. Application of column, paper and thin

layer chromatographic techniques, for the isolation of phytopharmaceuticals.

23. Phytopharmaceuticals

Isolation, identification and estimation of: caffeine, eugenol, digoxin, piperine, tannic acid,

diosgenin, hesperidin, berberine, calcium sennosides, rutin, glycyrrhizin, menthol, ephedrine,

quinine, andrographolides and guggul lipids.

24. Quality control and Standardization of herbal drugs

Quality control of herbal drugs as per WHO, AYUSH and Pharmacopoeial guidelines-Extractive

values, ash values, chromatographic techniques (TLC, HPTLC and HPLC) for determination of

chromatographic markers. Determination of heavy metals, insecticides, pesticides and

microbial load in herbal preparations.

25. Herbal formulations

Principals involved in Ayurveda, Sidha, Unani, Chinese and Homeopathic systems of medicines.

Preparation of Ayurvedic formulations like aristas, asava, ghutika, tailia, churna, avaleha, ghrita

and bhasmas: Unani formulations like majooms, Safoofs. Determination of alcohol contents in

arishtas & asavas.

26. Worldwide trade of crude drugs and volatile oils

Study of drugs having high commercial value and their regulations pertaining to trade.

27. Herbal cosmetics

Importance of herbals as shampoos (soapnut), conditioners and hair darkeners, (amla, henna,

hibiscus, tea), skin care (aloe, turmeric, lemon peel, vetiver).

28. Traditional herbal drugs

Common names, sources, morphology, active constituents and uses (traditional, folklore),

pharmacological and clinical uses of: punarnava (Boerhaviadiffusa), shankhpushpi (Convolvulus

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microphylla), lehsun (Allium sativum), guggul (Commiphora mukul), kalmegh (Andrographis

peniculata), tulsi (Ocimum sanctum), valerian (Valerian officinalis), artemisia (Artemisia annua),

chirata (Swertia chirata), ashoka (Saraca indica).

29. Plants based industries and research institutes in India

Knowledge about the herbal products being manufactured by premier herbal industries and

thrust area of the institutes involved in plant research.

30. Patents

Indian and International patent laws, proposed amendments as applicable to herbal/natural

products and processes: Intellectual Property Rights with special reference to

phytoconstituents.

31. Ayurvedic system of medicine

Theory, basic concept, diagnosis, various branches of treatment in ayurveda, types of the drug

formulation in Ayurveda and important Ayurvedic drugs and their uses, formulation of asavas,

arishtas, watika, churna, tailas, ghruta, lep.

32. Homeopathic system of medicine

Theory, basic concept, diagnosis, treatment, source of homeopathic medicines and important

homeopathic drugs and their uses

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PHARMACEUTICAL ANALYSIS

1. Importance of quality control in pharmacy

2. Acid-base titrations

Definitions of acids & bases according to Arrhenius & Lewis theory. Definitions of normality,

molarity, molality, & equivalent weight. Primary & secondary standards with examples &

differences between them. Standardization of strong acids & bases using primary & secondary

standards. Preparation of standard solutions of & calculations of equivalent weights of oxalic

acid, potassium acid phthalate, calcium chloride dihydrate, & sodium carbonate. Calculation of

factors involved in standardization of sodium hydroxide, hydrochloric acid, & oxalic acid. Direct,

back & differential titrations. Application of direct & back titrations to preparations like boric

acid & borax in a mixture, ammoniated mercury, milk of magnesia, & zinc oxide ointment.

Law of mass action, acid-base equilibria, pH scale, pH & hydronium ion concentrations in

aqueous systems, calculations of pH for weak acids & weak bases. Use & applications of pH

meter. Hydrolysis of salts. Strengths of acids & bases, dissociation constant.

Theory of acid-base indicators. Neutralization [titration] curves.

Definition, different types of buffers [chemical & biological], & their composition. Buffer

capacity, buffered isotonic solutions. Calculations involving preparation of various buffer

capacity solutions. Biological & pharmaceutical applications of buffers.

3. Non-aqueous titrations

Acid-base definitions according to Lowry-Bronsted, Lewis & Arrhenius concept. Factors

affecting strengths of acids & bases. Intrinsic structure & surrounding environment. Protophilic,

protogenic, amphiprotic & aprotic solvents. Acid-base equilibria in non- aqueous media.

Titrants & indicators used for the assay of acidic & basic substances. Preparation of perchloric

acid, formation of onium ion. Assay of 1o

, 2o, 3

o amines & amine hydrochlorides using

perchloric acid & the reactions involved in it. Standardization of sodium ethoxide solution.

Assay of phenols & phenobarbitone. General applications of non-aqueous titrations

4. Oxidation-reduction titrations

Definition of oxidation, reduction, oxidizing & reducing agent. Equivalent weight, the concept of

half reactions. Systematic balancing of half reactions with respect to:

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a. Oxalic acid-KMnO4,

b. FeSO4-ceric nitrate, &

c. I2-sodium thiosulphate solution titrations.

Calculation of equivalent weight of oxalic acid, KMnO4, FeSO4, permanganate & I2 from half-

reactions. Calculation of factors for titrations mentioned in a, b & c.

a) Redox titrations:

KMnO4 as a self indicator, it's preparation, standardization, & use in the assay of ferrous

gluconate tablets, H2O2, & NaNO2 solution.

b) Iodimetric & iodometric titrations. Definitions & difference between iodimetry &

iodometry. Preparation, standardization of iodine solution. Assay of ascorbic acid &

sulphur ointment by iodimetry. Assay of copper sulphate & ferric chloride by iodometry.

c) Bromometric titrations.

d) Iodate titrations. Definition. Preparation, standardization & use of KIO3 in the assay of

ascorbic acid & KI.

e) Cerimetric titrations. Preparation, standardization & use of ceric solutions in the assay

of paracetamol tablets. Its advantages over permanganate solutions.

f) Bromine titrations. Preparation, standardization & use of bromine solution in the assay

of phenol & isoniazid tablets.

g) Potassium dichromate titrations. Preparation, standardization & use of potassium

dichromate solution in the assay of ferrous ammonium sulphate.

5. Precipitation titrations

The principle of solubility product & sparingly soluble salts.

Titrants & indicators used in Mohr's, Volhard's, & Fajan's methods. Preparation &

standardization of silver nitrate & ammonium thiocyanate solutions. Assay of sodium chloride

by Mohr's method, use of nitrobenzene in the assay of halides, ammonium chloride, & thiourea

by Volhard's method. Calculation of factors in argentometric titrations. Titration curve method.

General applications of precipitation titrations.

6. Complexometric titrations

Difference between double salts & co-ordinate compounds. Definitions of coordination number

of metal ions, ligands- uni-, bi-, & multidentate. Complexing, chelating, & sequestering agents

with respective examples. Structure of complexes of platinum with ammonia. Ethylenediamine

tetraacetate [EDTA] as a multidentate ligand in complexometry. Coordinate compounds of

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EDTA with bi-, tri-, & tetravalent metal ions. Stability of complexes & factors affecting it, use of

buffers in EDTA titrations. Selective analysis of ions based on pH adjustments, use of masking &

demasking agents, pM or metal ion indicators. Standardization of EDTA solution, titration

curves, and examples of assays carried out by direct & back titrations & by replacement of one

complex by the other. Applications of complexometry in the assays of calcium gluconate, milk

of magnesia, zinc undecenoate ointment, & aluminium hydroxide gel. Assay of NaF by indirect

titration.

7. Gravimetry

Principles of gravimetry. Factors affecting precipitation, formation, & properties of the

precipitate. Colloidal state. Impurities in the precipitate, conditions of precipitation.

Precipitation from homogenous solutions, washing, drying, & ignition of the precipitate.

Experimental techniques of drying & ignition. Applications of gravimetry in pharmacy.

8. Extraction techniques

Liquid-liquid extraction, separation of mixtures by extraction. Distribution law. Successive &

multiple extraction [Craig method], continuous counter- current extraction. Effect of

temperature & pH on extraction. Inert solute, associate ion pair formation, emulsion problem

in extractions. Applications in pharmacy.

9. Potentiometry

Theory, ion-selective electrodes, measurement of potential, red-ox titration curve, pH

measurement, the relation of pH to potential. Applications in pharmacy.

10. Miscellaneous methods of analysis

Diazotization titrations. Kjeldahl nitrogen estimation. Karl Fisher titrations. Liquid gelenicals.

Oxygen flask Determination of alcohol content in liquid gelenicals. Oxygen flask combustion

method.

11. Calibration

Calibration of instruments.

12. General principles of spectroscopy

Wave-particle duality, wave properties, particulate properties. Line & band spectrum.

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Electromagnetic spectrum. Absorption & emission spectroscopy. Understanding of terms such

as absorbance, transmittance, absorptivities, molar absorptivity, E 1cm 1%,

λmax, the effect of solvent & pH on λmax.

13. Ultraviolet-visible Spectrometry

Different electronic transitions. Auxochromes & their effects, auxochromic, bathochromic &

hypsochromic shifts [red & blue shifts]. Beer-Lambert law, its derivation, deviations in Beer's

law. Single & double beam spectrophotometers covering sources of radiations, different

monochromators, detectors such as barrier cell, photocell, photomultiplier tube. Photodiode

array detector. Applications of this technique in qualitative & quantitative estimations giving

emphasis on problem-solving. Fieser-Woodward rules for calculations of theoretical λmax

values.

14. Spectrofluorimetry

Principle, definitions & types of luminescence. Mechanism of fluorescence & phosphorescence.

Singlet & triplet states & intersystem crossing. Fluorescence yield & factors affecting it.

Quenching of fluorescence & fluorescence quenchers. Structure & fluorescence. A brief

discussion of instrumentation. Applications of fluorimetry in pharmacy.

15. Flame photometry & atomic absorption spectrometry

Principle & instrumentation with emphasis on working & importance of different

components. Temperature, flame absorption & emission profiles. Interferences & their

avoidance. Quantitative estimations & applications.

16. Infrared spectrometry

Infrared region in EM spectrum. The principle, different stretching & bending vibrations.

Components [& their working] of a dispersive instrument. Fourier transform [FT] technique, FT

instruments & their comparison with dispersive instruments. Sample handling techniques.

Functional group & fingerprint regions in the spectrum. Functional groups identification & their

use in the characterization of compounds. Problems based on the identification of functional

groups from spectra of unknown compounds.

17. Proton nuclear magnetic resonance spectrometry

The principle involved in the technique. Knowledge about fundamental terms involved such as

quantized absorption, flipping of nucleus, spin number, magnetic moment, magnetogyric ratio,

relaxation, etc. Equations relating these terms to the frequency of radiation & magnetic field

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[without derivation of the equations]. Types of relaxation processes. Low & high-resolution

instruments. A brief discussion on the low-resolution instrumentation [60 MHz]. Quantitative

knowledge of the relationship between MHz & magnetic field. An introduction to

superconductivity magnets. Solvents & reference standards used. Setting up of NMR scale.

Sample preparation. Shielding & deshielding of a proton & its effect on chemical shifts.

Discussion on & importance of equivalent & non equivalent protons [number of signals],

chemical shifts [position of signal] & their calculation from the spectrum, chemical shifts of

different H's, splitting [multiplicity] of a signal, coupling constants [J values] , integration [area

under the signal]. Importance of these terms in identification [or confirmation] of different

functional groups. Significance & contribution of J value in stereochemistry. Prediction

[expected theoretical values] of chemical shifts & multiplicities for all protons from simple

structures containing up to 12-15 carbons. An introduction to FT-technique & its significance in 13

C-NMR spectrometry.

18. Mass spectrometry

Principle. Low & high-resolution instruments. Components & importance of each in brief.

Different types of mass spectrometric techniques. Brief knowledge of Chemical Ionization mass

spectrometry. Calculations of hydrogen deficiency index [HDI] or unsaturation index [UI]. Base

or parent peak, molecular ion, M + 1, M + 2 peaks. Calculations of molecular weight based on M

+1 & M + 2 peaks. Formation of molecular ion & further fragmentation. Rearrangements in

mass spectrometry. Major modes of fragmentations of hydrocarbons, hydroxyl compounds,

halogen compounds, aldehydes, ketones, carboxylic acids, and amines. Introduction [only] to

recent advances in MS.

19. Polarography.

Principle & instrumentation. Ilkovich equation [no derivation] & its importance. Dropping

mercury electrode [DME], saturated calomel electrode. Liquid-liquid junction potential,

polarographic cell. Explanation of origin of the S-shaped C-V curve. Applications

of this technique. Amperometric titrations, principles, instrumentation, & applications.

20. Nephelometry & Turbidimetry

Principles, Tyndall effect. Duboscq turbidimeter. Eeel's nephelometer. Applications.

21. Chromatography.

Principle, rate & plate theory, Van Deemter equation & the parameters affecting

separation/band broadening. Classification of chromatography, retention factor. A detailed

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study of thin layer chromatography [TLC], preparative TLC, paper chromatography [PC], column

chromatography, gas chromatography [GC / GLC].

Qualitative & quantitative applications of the above techniques. An introduction to high

performance TLC [HPTLC], comparison of TLC & HPTLC. A brief introduction to high pressure /

performance liquid chromatography [HPLC].

22. Miscellaneous

An introduction to electrophoresis. An introduction to lasers & masers.

Statistical treatment to experimental data. Sampling techniques & applications in

pharmaceutical industry.

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BIOCHEMISTRY

1. Cell

Revision of ultrastructure of the cell, functions of various cellular constituents. Applications of

biochemical principles to the pharmacy.

2. Carbohydrates

Types of carbohydrates, their functions, digestion, & absorption. Aerobic & anaerobic oxidation

with energetics. Glycogenesis, glycogenolysis, & gluconeogenesis. Hexose monophosphate

shunt [HMP shunt]. Diseases associated with carbohydrate metabolism.

3. Proteins

Different types of proteins. Their functions, digestion & absorption. Denaturation & its effect on

biological activity. Renaturation of proteins. Urea formation, urea cycle, creatinine formation.

Transamination & deamination. Proteins as enzymes.

4. Lipids

Different types of lipids. Their functions, digestion, absorption & metabolism. (Beta-Oxidation

of fatty acids with energetics. Biosynthesis of cholesterol [from acetate], adrenocorticoids,

androgens, progesterone, estrogens, & bile acids / salts. Ketone bodies, their formation &

biochemical significance. Diseases associated with lipid metabolism.

5. Vitamins

Definition. Classification, structures [except B12] biochemical role, sources, daily requirements,

& deficiency symptoms. Vitamins as co-factors in biochemical reactions.

6. Biological oxidations & reductions

Oxidation-reduction systems in the body their role. Oxidative phosphorylation &

Electron transport chain. Cytochromes & inhibitors of the same.

7. Enzymes

Classification & their various roles. Enzyme co-factors. Enzyme kinetics. Michaelis-Menton

equation along with its transformations. Double reciprocal plot. Factors affecting enzyme

action. Enzyme inhibition, competitive & non-competitive, & kinetics.

8. Nucleic acids

Different types of nucleic acids [NAs] & their composition. Purine & pyrimidine bases, sugars, &

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phosphoric acid. Nucleosides & nucleotides. Formation of NAs & their backbone. Different ways

of representing DNA & RNA molecules. Physico-chemical properties of NAs. Their stability in

acidic & basic solutions. Isolation, purification & identification, buoyant density, sedimentation

coefficient, & Svedberg constant of NAs. De-novo biosynthesis of NAs. DNA & the Watson-Crick

model & its features. DNA as

the bearer of genetic information. The Central dogma of molecular genetics & the processes

defined in the same. Replication of DNA. Different types of RNAs with their special features &

functions. Minor or rare bases. Transcription & translation. Different post-translational

modifications of proteins. Triplet codon & the codon dictionary. Mutations. An introduction to

different types of mutations. Their nature & repair.

9. Hereditary diseases.

Eliptocytosis, spherocytosis, HNPCC, diabetes insipidus.

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BIOTECHNOLOGY

1. Plant Cell and Tissue Culture

Structure of plant cell, DNA, Genes and chromosomes.

1. Cell and tissue culture,

a. Requirements.

b. Callus culture, suspension culture, batch culture.

c. The concept of somatic hybridization, somatic embryogenesis.

2. Processes and applications,

a. Isolation and immobilization of enzymes and plant cells and application.

b. Protoplast and cell fusion.

c. Germplasm conservation.

d. Production of secondary metabolites by plant tissue culture.

e. Gene transfer techniques.

2. Animal Cell Culture

Introduction to animal cell culture, medium used in ATC. Use of FCS, primary culture, secondary

culture, cell line. Cloning: concept and application with technical hurdles. Transgenic animals as

a source of food, organs and tissues, concept of xeno transplant.

3. Fermentation Technology and Industrial Microbiology

1. Fermentation as a biochemical process, types of fermentation.

2. Fermenter - working and construction, accessory components, modification.

3. Fermentation monitoring and in situ recovery of products.

4.Recombinant DNA Technology

Basic concepts

a) Introduction.

b) Role of a restriction endonuclease, DNA ligase, DNA polymerase, Reverse transcriptase.

5. Process and Applications

a) Constructing Recombinant DNA molecules.

DNA Clones sources of DNA for cloning.

DNA vectors, role of expression vectors.

Host cell for recombinant work.

Method for screening and selecting transformants.

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Expression of foreign genes.

Uses of recombinant DNA.

b) PCR and applications.

Human gene therapy concept and applications.

c) Drug delivery systems in gene therapy.

6. Biotechnology Derived Products

a) Sources and upstream processing.

Introduction.

Escherichia coli as a source of recombinant, therapeutic protein.

Additional production systems,

Yeast.

Fungal production systems.

Transgenic animals.

Transgenic plants.

Insects cell-based systems.

Upstream processing.

b) Downstream processing.

Product analysis,

Introduction.

Protein-based contaminant.

Removal of an altered form of the protein of interest from the product stream.

Determination of protein concentration.

c) Immunological approaches to detection of contaminant, Endotoxin and other

pyrogenic contaminants.

Pyrogen detection.

DNA as a contaminant.

Microbial and viral contaminant.

Viral assays.

Miscellaneous contaminants.

Validation studies.

d) Production and purification of recombinant proteins like, Insulin, Growth

hormones, somatostatin, interferons, only examples of recombinant blood

products.

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MICROBIOLOGY

1.Introduction to Microbiology

Scope and application to pharmacy field. Whittaker's Five Kingdom concept, historical

development - biogenesis Vs. abiogenesis, Germ theory of fermentation, Germ theory of

disease, the contribution of Leeuwenhoek, Robert Koch, Jenner, Louis Pasteur and Ehrlich.

2.Microscopy and staining technique

The principle, ray diagram, construction, working and applications of light compound, dark

field, phase contrast, Fluorescence & electron microscope. The concept of resolving power,

Magnification power, numerical aperture and angular aperture and working distance. The

principle application of oil immersion microscopy. Theory of staining, principle and technique

of staining procedure - Monochrome, Gram, acid-fast, negative, capsule, endospore.

3.Biology of Microorganisms

Cultural characteristics, pure culture techniques

a) Bacteria - Morphology and fine structure of bacteria, Nutritional requirement and type of

culture media, growth and growth curve of bacteria, physical condition for growth,

measurement of bacterial growth (Counting Methods), Reproduction in bacteria, genetic

exchange - transformation, conjugation, and transduction, development of drug resistance by

recombination and mutation, preservation of bacterial culture. Biochemical properties (sugar

fermentation and IMVIC test). Pathogenesis of Staphylococcus, Mycobacterium. Salmonella

Introductory study of disease-causing rickettsia, the importance of actinomycetes in antibiotic

production.

4.Fungi and Viruses

b) Fungi:- Introduction, general characteristics, morphology, the industrial and medical

significance of Saccharomyces Cerevisae, Penicillium and Aspergillus, Candida Albicans,

Epidermophyton, and trichophyta.

c) Viruses: - Introduction, structure and general properties Bacteriophages - Lytic and

Lysogenic cycle, Epidemiological uses of Bacteriophages, human viruses - Cultivation and

Multiplication virus-host cell interaction, Pathogenesis of HIV and Prions, types of Tumor

viruses.

5.Aseptic Technique

The omnipresence of microorganisms, the importance of asepsis, sources of contamination and

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methods of prevention, Principle, construction & working of laminar airflow bench.

6.Sterilization & Disinfection

a) Concept and classification, principle and methods of sterilization, Mechanisms of cell

injury.

b) Construction working & applications of moist heat & dry heat sterilizer, gamma

radiation sterilizer, filtration sterilizer. Indicators of sterilization, microbial death, kinetic

terms-D value, z value.

c) Terminology of chemical antimicrobial Agents, Chemical classification of different

disinfectants, characteristics of ideal disinfectants, factors affecting the action of

disinfectants, evaluation methods (RW Coeff.), Kelsey Sykes test, Chick Martin test.

7.Microbial spoilage

Types of spoilage, factors affecting spoilage of pharmaceutical products.

9.Vaccines & Sera

Manufacturing (seed lot system) and quality control of bacterial vaccines & Toxoids (Tetanus,

TAB, Cholera, BCG, DPT), Viral vaccine (Polio- Salk Sabin, Rabies, MMR, Hepatitis, Chickenpox,

influenza), Antisera (diphtheria, tetanus), antiviral Antisera (rabies). Preparation of allergenic

extracts & diagnostics.

10.Microbial Assay

Importance, general methods of assay of antibiotics (Cup & plate method, paper disc method,

turbidometry, dilution method), methods for fungicidal & antiviral compounds, assay, microbial

limit tests.

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PATHOPHYSIOLOGY

1.Basic principles of cell injury and adaptation

Causes, pathogenesis and morphology of cell injury, apoptosis and necrosis.

2.Basic mechanisms of inflammation and repair

Pathogeneses of inflammation. Chemical mediators in inflammation. Pathogenesis of

chronic inflammation. Repair of wounds in the skin, factors influencing healing of

wounds.

3. Disorders of fluid, electrolyte and acid-base balance

4. Disorders of homeostasis: white blood cells, lymphoid tissues, and

red blood cells related diseases.

5. Immunopathology including amyloidosis

a) Host parasite Relationship: - normal microbial flora of human body, infection vs.

disease, Pathogenicity vs. Virulence, Koch & Rivers Postulates, Reservoir of

infection-sources of infection, Portals of Entry, Portals of exit, vectors of infection,

communicability of disease, recognized symptoms of microbial disease,

classification of immunity.

External defense mechanism of host: Skin, Mucus membrane, chemical

Secretions, Naturally occurring microbial flora.

Internal defense Mechanism: Inflammation, fever, natural killer Cells, Phagocytic

Cells, Soluble mediators-complement Lymphokines, Interferons.

b) Immune response :

Specific immunity & immune response

Humoral immunity antibody response, mediators of Humoral immunity, basic

structure of antibody, antibody classes & functions, maturation of immune

response, immunologic memory.

Antigens: specificity & Immunogenicity, Natural vs. artificial Antigens,

Soluble, cellular antigens, thymus independent antigen, adjuvant.

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Hypersensitivity and its types

Cellular immunity: Transplantation immunity, Cellular immunity to viruses, Implications of

T-cell response. Acquisition of specific immunity: Natural vs. Passive acquisition.

Mechanism of autoimmunity. Classification of autoimmune diseases in man.

Transplantation and allograft reactions, mechanism of rejection of allograft.

Acquired Immune Deficiency Syndrome (AIDS).

6. Infectious diseases

Hepatitis - Infective hepatitis.

Sexually transmitted diseases (syphilis, gonorrhea, HIV). Pneumonia, typhoid,

urinary tract infections. Tuberculosis. Leprosy. Malaria. Dysentery (Bacterial and

amoebic).

7. Neoplastic diseases

Disturbances of growth of cells. General biology of tumors, differences between

benign and malignant tumors. Classification of tumors. Historical diagnosis of

malignancy. Etiology and pathogenesis of cancer. Invasions, metastasis, patterns of

spread of cancer. Environmental carcinogenesis.

8. Pathophysiology of common diseases

Parkinsonism. Schizophrenia. Depression and mania

Stroke (ischemic and hemorrhage). Hypertension. Angina. Myocardial infarction,

CCF. Atherosclerosis.

Diabetes mellitus.

Peptic ulcer and inflammatory bowel disease. Cirrhosis and alcoholic liver diseases.

Acute and chronic renal failure.

Asthma and chronic obstructive airway diseases.

9. Laboratory tests for Liver function tests and kidney function tests

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BIOPHARMACEUTICS AND PHARMACOKINETICS

1.Bio-pharmaceutics

a) The fate of drug after drug absorption, various mechanisms for drug absorption, drug

concentration in blood, biological factors in drug absorption, physicochemical factors,

dosage form consideration for gastrointestinal absorption.

b) Drug Absorption:

Gastrointestinal absorption-biological considerations.

Gastrointestinal absorption - physicochemical considerations.

Gastrointestinal absorption-role of the dosage form.

Pharmacokinetics. Compartmental and non-compartmental pharmacokinetics.

Biotransformation, drug disposition - distribution, drug disposition - elimination.

Variability-Body weight, age, sex and genetic factors. Pharmacokinetic variability-

diseases. Pharmacokinetic variability-drug interactions. Individualization and

optimization of drug dosing regimens.

2.Bio-availability & Bio-equivalence

Quality parameters of dosage forms. Assay methods & its validation.

Physicochemical properties of drugs & added substances and its effect on preparations and

biological availability of dosage forms. Pharmaceutical properties of dosage forms,

disintegration, dissolution rate. Biological, pharmacological effects of dosage forms. Factors

affecting Bioavailability, Determination of bioavailability.

Significance of bio-equivalence studies. Statistical analysis of bioequivalence studies.

Development, scale up & post approval changes [SUPAC] & in vitro [dissolution] in vivo [plasma

concentration profile] correlation or IV/IV correlation (IVIVC). Multi stage - Bioequivalence

studies. Therapeutic equivalence. Titration design for clinical rationales. New Drug Application

[NDA].

3.Bio- pharmaceutical statistics

Post Marketing Surveillance. Process Validation.

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CLINICAL PHARMACY AND THERAPEUTICS

1. General Principles, preparation, maintenance, analysis of observational records in clinical

Pharmacy.

2. Clinical trials, type and phases of clinical trials, placebo, ethical and regulatory issues

including Good clinical practice in clinical trials.

3. Therapeutic drug monitoring, adverse drug reaction (ADR), types of ADR, Mechanism of

ADR. Drug interaction, Monitoring and reporting of ADR and its significance.

4. Drug information services, Drug interactions.

5. Drug interaction in pediatric and geriatric patients, drug treatment during pregnancy,

lactation and menstruation.

6. Pharmacovigilance, Therapeutic drug monitoring, Neutraceuticals, essential drugs and

rational drug usage.

7. Age-related drug therapy: concept of posology, drug therapy for neonates, pediatrics and

geriatrics. Drugs used in pregnancy and lactation.

8. Drug therapy in gastrointestinal, hepatic, renal, cardiovascular and respiratory Disorders.

9. Drug therapy for neurological and psychological disorders.

10. Drug therapy in infections of respiratory system, urinary system, infective meningitis, TB,

HIV, malaria and filaria.

11. Drug therapy for thyroid and parathyroid disorders, diabetes mellitus, menstrual cycle

disorders, menopause and male sexual dysfunction.

12. Drug therapy for malignant disorders like leukemia, lymphoma and solid tumors.

13. Drug therapy for rheumatic, eye and skin disorders.

HUMAN ANATOMY & PHYSIOLOGY

1. Cell physiology

Cell, Cell junctions, transport mechanisms, homeostasis, ion channels, secondary messengers.

2. The Blood

Composition and functions of blood, RBC, WBC, platelets. Homeostasis, blood groups,

mechanism of clotting. Introduction to disorders of the blood.

3. Gastrointestinal tract

Structure of the gastrointestinal tract, functions of its different parts including those of liver,

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pancreas and gallbladder, various gastrointestinal structures and their role in the digestion and

absorption of food.

4. Respiratory System

Structure of respiratory organs, functions of respiration mechanism and regulation of

respiration, respiratory volumes and vital capacity.

5. Autonomic nervous system

Physiology and functions of the autonomic nervous system. Mechanism of neurohumoral

transmission in ANS.

6. Sense organs

Structure and physiology of eye (vision), ear (hearing), taste buds, nose (smell) and skin.

7. Skeletal System

Structure and function of the skeleton. Articulation and movement. Disorders of bones and

joints.

8. Central Nervous system

Functions of different parts of the brain and spinal cord. Neurohumoral transmission in the

central nervous system, reflex action, electroencephalogram, specialized functions of the brain,

cranial nerves and their functions.

9. Urinary System

Various parts Structure and functions of the kidney and urinary tract. Physiology of urine

formation and acid-base balance. Brief Introduction to disorders of the kidney.

10. Endocrine Glands

Basic anatomy and physiology of pituitary, thyroid, parathyroid, adrenal glands and pancreas.

Local hormones. A brief introduction to disorders of various endocrine glands.

11. Reproductive System

Structure and functions of male and female reproductive system. Sex hormones, physiology of

menstrual cycle, and various stages of pregnancy and parturition.

12. Cardiovascular system

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Anatomy of heart and blood vessels, physiology of blood circulation, cardiac cycle, conducting

system of the heart, heart sound, electrocardiogram, blood pressure and its regulation.

13. Lymphatic system

Composition, formation and circulation of lymph. Spleen and its functions.

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PHARMACEUTICAL ENGINEERING

1. Fluid flow

Type of flow, Reynold's number, viscosity, the concept of the boundary layer, basic equation of

fluid flow, the study of valves, flow meters, manometers and measurement of flow and

pressure including mathematical problems.

2. Heat transfer

Source of heat, mechanism of heat transfer, the laws of heat transfer, steam and electricity as

heating media, determination of requirement of the amount of steam/electrical energy, steam

pressure, boiler capacity, mathematical problems on heat transfer, steam traps and reducing

valve, lagging etc.

3. Evaporation

The basic concept of phase equilibrium, factors affecting evaporation, evaporators, film

evaporators, single effect and multiple effect evaporators, mathematical problems on

evaporation.

4. Distillation

Raoult's law, phase diagram, volatility: simple steam and flash distillation, principles of

rectification, Mc-Cabe Thiele method for calculations of a number of theoretical plates,

azeotropic and extractive distillation, mathematical problems on distillation.

5. Drying

Moisture content and mechanism of drying, the rate of drying and time of drying calculations,

classifications and types of dryers, dryers used in pharmaceutical industries and special drying

methods like freeze drying and lyophilization, mathematical problems in drying.

6. Size reduction and size separation

Definition, objectives of size reduction, factors affecting size reduction, laws governing in

energy and power requirement of a mill, types of mills including ball mill, hammer mill, fluid

energy mill, micronizer, Quadro co-mil, multi mill etc.

7. Extraction

Theory of extraction, extraction methods, equipment for various types of the extraction

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process.

8. Mixing

Theory of mixing, solid-solid, solid-liquid and liquid-liquid mixing equipment.

9. Crystallization

Characteristics of crystals like purity, size, shape, geometry, habit, forms, size and factors

affecting them. Solubility curves and calculation curves and calculations of heat balance around

S Swanson's Walker crystallizer , supersaturation theory and its limitations, Nucleation

mechanism, crystal growth, study of various types of crystallizers, tanks, agitated batch,

Swanson’s Walker, single vacuums, circulating magma and crystal crystallizers, cracking of

crystals and its prevention. Numerical problems on yields. Introduction to polymorphism.

10. Filtration and Centrifugation

Theory of filtrations, filter aids, filter media, industrial filters, including filter press, rotary filter,

edge filters, filter leaf and laboratory filtration equipment etc., Factors affecting filtration,

mathematical problems on filtrations, optimum cleaning cycle in batch filters. Principles of

centrifugation, industrial centrifugal filters and centrifugal sedimentars.

11. Dehumidification and humidity control

Basic concept and definition, wet bulb and adiabatic saturation temperatures, psychometric count and measurement of humidity, application of humidity measurement in pharmacy, equipment for humidification and dehumidification operations

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12. Refrigeration and air conditioning

Principles and applications of refrigeration and air conditioning.

13. Material of constructions

General study of composition, corrosion, resistance, properties and applications of the

materials of construction with special reference to stainless steel, glass, ferrous metals, cast

iron, non ferrous metals, copper and alloys, aluminum and alloys, lead, tin, silver, nickel and

alloys, chromium and non metals, stone, slate, brick, asbestos, plastics, rubber, timber,

concrete. Corrosion and its prevention with reference to commonly used material in

pharmaceutical plants.

14. Automated process control systems

A process variable, temperature, pressure, flow level and vacuum and their measurement.

Elements of automatic process control and introduction to automatic process control. Elements

of computer-aided manufacturing (CAM).

15. Industrial hazards & safety precautions

Mechanical, chemical, electrical, fire, dust, noise hazards, Industrial dermatitis, accident,

records, safety requirements/equipment etc.

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PHARMACEUTICAL MANAGEMENT

1. Introduction to management

Types of management. Basic concepts of management, management process, function and

principles. Levels of management, pharmaceutical management art, science or profession.

Social responsibilities of management, functions of management.

2. Planning and Forecasting

Planning: Nature, process and types of planning, steps in the planning process, planning

premises. Advantages and limitations of planning. Management by objective, meaning,

objective features, advantages and limitations. Forecasting: meaning, nature, importance,

limitations. Techniques of forecasting.

3. Organization

Definition, nature, theories, functions, line and staff organization concepts.

4. Research Management

R & D organizations and research categories. Elements needed for an R & D organization.

Technology transfer.

5. Inventory Management

Objective and functions of inventory control. Types of inventories. Requirements of effective

inventory control.

6. Communication

Nature, types of communication, process, channels and barriers of communication. Limitations

of communications. Importance in pharmaceutical industries.

7. Marketing Research

New product selection, product management, advertising.

8. Leadership and motivation

Leadership: meaning, nature, leadership styles. Theories of leadership. Motivation: meaning,

nature, importance. Theories of motivation.

9. Human resource and development (HRD)

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Definition, HRD methods, HRD process, HRD in Indian industry.

10. GATT

General Agreement on Tariff and Trade and its impact on the pharmaceutical industry. History

of GATT, its impact on the pharmaceutical industry. Pharmaceutical market in

India.

11. World trade organization (WTO) and trade-related intellectual property rights

(TRIPS)

Introduction to WTO. Types of intellectual property rights: industrial property and copyrights

Indian Patent Acts, 1970 with the latest amendment. Definition, types of patents.

12. Standard institutions and regulatory authorities

1. Bureau of Indian Standards (BIS).

2. International Organization for Standardization (ISO).

3. United States of Food and Drug Administration (USFDA).

4. Central Drug Standard Control Organization (CDSCO).

5. International Conference on Harmonization (ICH).

6. World Health Organization (WHO).

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PHARMACEUTICAL JURISPRUDENCE

1. Historical background Drug legislation in India, Code of Ethics for Pharmacists.

2. The Pharmacy Act 1948 (inclusive of recent amendments).

3. Drugs and Cosmetics Act 1940, Rules 1945, including New Drug applications.

4. Narcotic Drugs and Psychotropic Substances Act, and Rules thereunder.

5. Drugs and Magic Remedies (Objectionable Advertisements) Act 1954.

6. Medicinal and Toilet Preparations (Excise Duties) Act 1955, Rules 1976.

7. Medical Termination of Pregnancy Act 1970 and Rules 1975.

8. Prevention of Cruelty to Animals Act 1960.

9. Drug (Price Control) Order.

10. Shops and Establishment Act.

11. Factory Act.

12. Consumer Protection Act.

13. Indian Pharmaceutical Industry- An Overview.

14. Industrial Development and Regulation act 1951.

15. Introduction to Intellectual Property Rights and Indian Patent Act 1970.

16. An Introduction to Standard Institutions and Regulatory Authorities such as BIS,

ASTM, ISO, TGA, USFDA, MHRA, ICH, WHO.

17. Minimum Wages Act 1948.

18. Prevention of Food Adulteration Act 1954 and Rules

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DISPENSING & HOSPITAL PHARMACY

1. Introduction to laboratory equipment, weighing methodology, handling of

prescriptions, labeling instructions for dispensed products.

2. Posological calculations involved in the calculation of dosage for infants. Enlarging

and reducing formula, displacement value.

3. Preparations of formulations involving allegation, alcohol dilution, isotonic solution.

4. Study of current patent and proprietary products, generic products and

selected brand products, indications, contraindications, adverse drug reactions,

available dosage forms and packing of

Antihypertensive drug

Antiamoebic drugs

Antihistaminic drugs

Antiemetic drugs

Antacids and ulcer healing drugs.

Antidiarrheals and laxatives

Respiratory drugs

Antibiotics

Analgesics and antipyretic drugs.

8. Compounding and dispensing of following prescriptions

Mixtures

Solutions

Emulsions

Lotions (External preparations)

Liniments (External preparations)

Powder

Granules

Suppositories

Ointments / Paste

Cream

Incompatibility: Prescription based on physical, chemical and therapeutic

incompatibility. Tablets

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Inhalations

9. Reading and counseling of prescriptions from the clinical practice.

Designing from mock Pharmacy: Layout and structure of retail Pharmacy,

compounding, dispensing, storing, labeling, pricing, recording and counseling of

prescription.

Procurement of information for the given drug for drug information services.

Preparation of Hospital Formulary.

RECOMMENDED STANDARD REFERENCE BOOKS

FOR PHARMACEUTICS and related subjects:

1. Pharmaceutics: Drug Delivery and Targeting, By Yvonne Perrie, Thomas Rades, Pharmaceutical Press, second edition.

2. Introduction to the Pharmaceutical Sciences, By Nita K. Pandit. 3. Aulton's Pharmaceutics: The Design and Manufacture of Medicines, edited

by Michael E. Aulton, Kevin Taylor. 4. Remington: Essentials of Pharmaceutics, By Linda Ed Felton. 5. Pharmaceutical Dosage Forms and Drug Delivery, Second Edition, CRC Press,

Pharmacy Education Series, by Ram I. Mahato, Ajit S. Narang. 6. Essentials of Physical Pharmacy, by CVS Subramanyam, Vallabh Prakashan. 7. Biopharmaceutics& Pharmacokinetics, D. M. Brahmankar. 8. Modern Pharmaceutics, Gilbert S. Banker and Christopher Rhodes. 9. Essentials of Physical Chemistry, B.S.Bahl, G.D.Tuli, S. Chand ltd. 2000. 10. Martin’s Physical Pharmacy and Pharmaceutical Sciences, Patrick J. Sinko,

Lippincott Williams & Wilkins, 2011 11. Textbook of Pharmaceutics, E.A. Rawlins, Ballière, Tindall, 1977 12. Handbook of Cosmetic Science and Technology, Third Edition 13. Martindale : The Complete Drug Reference: 36 th Ad. 14. Pharmaceutical Excipients

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15. Developing Solid oral Dosage form: Pharmaceutical Theory & Practice 16. Pharmaceutical Preformulation and Formulatio, Mark Gibson 17. Foundation of Pharmacokinetics, Aldo Rescigno 18. Ansel,s Pharmaceutical Dosage Forms and Drug Delivery System, Allen, LV 19. Biopharmaceutics and Clinical Pharmacokinetics, Notari, RE 20. Cooper and Gunn's Tutorial Pharmacy, Carter, SJ 21. Biopharmaceutics and Pharmacokinetics, John Wagner, Drug Intelligence

Publications, 1971. 22. Essentials of Physical Chemistry, B.S.Bahl, G.D.Tuli, S. Chand ltd. 2000. 23. Martin’s Physical Pharmacy and Pharmaceutical Sciences, Patrick J. Sinko,

Lippincott Williams & Wilkins, 2011 24. Textbook of Pharmaceutics, E.A. Rawlins, Ballière, Tindall, 1977

REFERENCE BOOKS FOR PHARMACEUTICAL CHEMISTRY/MEDICINAL CHEMISTRY:

1. Organic Chemistry – Morrison & Boyd, 4th edn, 2011 Pearson, New Delhi.

2. Organic Chemistry – I.L. Finar, Vol- I and Vol-II.

3. Wilson and Giswolds Text Book of Organic, Medicinal & Pharmaeutical

Chemistry , 12th edn.Eds-J.M. Beale Jr, and J.H. Block , Lippincott Williams and

Wilkins , 2013

4. Foye’s Principle of medicinal Chemistry –Eds-Thomas Lemke,D.A.Williams, ,

Lippincott Williams & Wilkins, New Delhi.

5. Advanced Organic Chemistry, B.S. Bahl and Arun Bahl, S Chand and Company

Ltd., Ram Nagar, New Delhi, 1st Edition.

6. Stereochemistry Conformation and mechanism by P.S. Kalsi, 5th Edition, New Age

International Publishers, New Delhi.

7. Heterocyclic Chemistry, 3rd Edition, Raj K Bansal, New Age International

Publishers, New Delhi.

8. Indian Pharmacopoeia all editions and volumes.

9. Advanced Organic Chemistry, Jerry March, Wiley, 1992. 10. Bentley and Driver's Textbook of Pharmaceutical Chemistry, Atherden, lm 11. Burger's Medicinal Chemistry, 6 vol, Abraham, DJ 12. Burger's Medicinal Chemistry and Drug Discovery, 5 vols set, Wolff, ME 13. Stereochemistry of organic compounds, Ernest Eliel, Wiley India.

14. A guide book to Reaction mechanism in organic chemistry-Peter Sykes

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15. Reaction mechanism in organic chemistry- S M Mukherjee and S P

Singh,MacMilan

16. Drug Design. Edited by E.J. Ariens -Medicinal Chemistry; a Series of Monographs,

V.11

17. Drug design –Dr.V.M.Kulkarni and Dr.K.G.Bothara

18. Photochemistry and Pericyclic reactions by J. Singh

19. Pericyclic reactions-Ian Fleming

20. Pericyclic reactions -W .Carrurther

REFERENCE BOOKS FOR PHARMACEUTICAL ANALYSIS:

1. Indian Pharmacopoeia all editions and volumes

2. Instrumental Methods of Chemical Analysis (Analytical Chemistry) By. Dr. B.K.

Sharma, Goel Publishing House, Meerut. 18th Edition (1999) (Part -

Spectroscopy)


Sharma, Goel Publishing House, Meerut. 18th Edition (1999) (Part -

Chromatography)


Sharma, Goel Publishing House, Meerut. 18th Edition (1999) (Part – Analytical

Chemistry

5. INSTRUMENTAL METHODS OF ANALYSIS by H.H. Willard, L.L. Merrit and

J.A. Dean

6. Introduction to Spectroscopy- D.L.Pavia,G.M.Lampman,G.S.Kriz

7. Principles of Instrumental analysis- Skoog, Holler, Crouch

8. Spectrometric Identification of Organic Compounds- Silverstein, R.M. and

Webster, F.X., 6th ed., Wiley, New York, 1998

9. Applications of Absorption Spectroscopy of Organic Compounds- John R. Dyer,

Prentice-Hall,

10. Instrumental methods of chemical analysis- H.Kaur, Pragati Prakashan

https://www.google.co.in/search?tbo=p&tbm=bks&q=bibliogroup:%22Medicinal+Chemistry%3B+a+Series+of+Monographs,+V.11%22&source=gbs_metadata_r&cad=2

https://www.google.co.in/search?tbo=p&tbm=bks&q=bibliogroup:%22Medicinal+Chemistry%3B+a+Series+of+Monographs,+V.11%22&source=gbs_metadata_r&cad=2

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REFERENCE BOOKS FOR HUMAN ANATOMY/PHYSIOLOGY/

PATHOPHYSIOLOGY,/PHARMACOLOGY:

1. RANG AND DALE'S Pharmacology, 7th Edition, M.M Dale, J.M Ritter, R.J Flower, G.Henderson H.P, Rang

2. Goodman & Gilman's the Pharmacological Basis of Therapeutics, Laurence L. Brunton

3. Basic & Clinical Pharmacology, Bertram G. Katzung, Susan B Masters, Anthony J Trevor

4. Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, David E. Golan

5. Martindale: The Complete Drug Reference, Sean C. Sweetman 6. Goodman & Gilman’s The Pharmacological Basis of Therapeutics 7. Color Atlas of Pharmacology, 3rd Edition, Heinz Lullmann, Klaus Mohr, Lutz Hein,

Detlef Bieger, Thieme, Stuttgart. New York. 8. Lippincott’s Illustrated Reviews: Pharmacology, 6th Edition, Springhouse

publishers 9. Essential of Medical Pharmacology, KD Tripathi 10. Principles of Anatomy and Physiology, Gerard Tortora, 12th edition 11. Ross & Wilson, Anatomy and Physiology, 12th edition, Churchill Livingstone 12. Pharmacology and Pharmacotherapeutics –R.S.Satoskar, S.D. Bhandarkar ,

Popular Prakashan, Mumbai 13. Pharmacotherapy: A pathophysiologic Approach, by Joseph T. Dipirio, Robert L.

Talbert, Gacy C. Yee, Gary R. Matzke, Barbara G. Wells, L. Micael Possey

REFERENCE BOOKS FOR PHARMACOGNOSY:

1. Textbook of Pharmacognosy, Thomas Edward Wallis, J & A Churchill ltd., London 2. Pharmacognosy, Tyler, 8th edition, Lea and Febiger, Philadelphia 3. Pharmacognosy 42nd Edition (Sep 2008), C.K. Kokate, A.P. Purohit, S.B. Gokhale (Nirali

Prakashan)

4. Textbook of Pharmacognosy-Noel M Ferhuson

5. Textbook of Pharmacognosy-C.S.Shah and J.S.Qadry

6. Textbook of Pharmacognosy-H.W.Youngken

7. Textbook of Pharmacognosy and Phytochemistry-Dr.Biren Shah

8. Textbook of Pharmacognosy-T.N.Vasudevan, Kirti Laddha

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REFERENCE BOOKS FOR MARKETING MANAGEMENT:

1. Marketing Management, Phillip Kotler, Prentice Hall, 2003 2. Pharmaceutical Marketing in India, Subba Rao Chaganti, Excel Books Pvt. Ltd

REFERENCE BOOKS FOR BIOCHEMISTRY:

1. Lehninger’s Principles of Biochemistry, David L. Nielson, Macmillan Learning, 2012

2. Harper’s Illustrated Biochemistry, 28th edition, Robert Murray, David Bender, Mcgraw-hill, 2009

REFERENCE BOOKS FOR MICROBIOLOGY:

1. Microbiology, Michael Pelczar, 5th edition, Tat McGraw-Hill Publishing Company Ltd.

gpat 2020 (graduate pharmacy aptitude test) · introduction & scheme of examination national...

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