$1M STTR Grant OpportunityPlease consider applying to a new grant opportunity offering three $333,333 (direct) Programmatic Investment Grants.

This new $1,000,000 opportunity is supported by generous donors from the 2014 Hutch Holiday Gala. Each team science award will be divided evenly over three years for collaborative, translational research projects with current or clear plans to begin clinical trials, screenings or guidelines within the next five years.

This month, STTR hosted two coffee hours to answer questions about the grant (LOI deadline: September 25, 2015) and allowed investigators to meet and discuss collaborations and projects. If you have any specific questions about this grant, please email STTRCancer@fredhutch.org and we can connect you with faculty who attended and expressed interest in collaborations.

Grant Road MapsDo you have a funding strategy for the next 3

years? Has your research taken a new direction and you are uncertain of the possible funding sources available to you? STTR is able to work with you to identify NIH and foundation grant opportunities to help fund your research. We will create a timeline of milestones and deadlines to help you achieve your grant writing goals.

FAll 2015 NEWS FROM STTR

S O L I D T U M O R T R A N S L A T I O N A L R E S E A R C HF r e d H u t c H i n s o n c a n c e r r e s e a r c H c e n t e r • u W M e d i c i n e • s e at t l e c a n c e r c a r e a l l i a n c e

Mail stop c3-168 1100 FairvieW ave. n., po Box 19024 seat tle, Wa 98109-1024 206.667.6661 st trcancer.org

Mouse Model Database Partnering with Fred Hutch Comparative Medicine Shared Resources,

we are compiling a shared list of existing mouse models across the Consortium which is now available on our SharePoint site. The vision is to make research more efficient by: 1) Saving researchers time by doing a quick online search to know what mouse strains are available and 2) Saving money by using a mouse line generated internally vs. shipping mice across the country or ordering from a private company.

If you would like to contribute mouse model information to our password-protected database, please email STTRCancer@fredhutch.org. Vist the Mouse Model database here:

https://share.fhcrc.org/sites/cancer-center/sttr/Pages/Mouse-Model-Database.aspx

*Apply Now*

*Request a Meeting*

Fall 2015S O L I D T U M O R T R A N S L AT I O N A L R E S E A R C H

Data Entry & VisualizationSTTR Biotool

TCGA (publicly) as well as clinically annotated data provided by investigators (by permission) is available in Oncoscape to provide a robust platform for exploration and hypothesis generation. Data by type:

TCGA ~6,000 tumor samplesBrain >900 primary brain tumor samplesLung >700 Stage IV lung cancer samples including

Oncoplex dataHead & Neck >100 squamous cell carcinoma banked

specimenColorectal - 137 samples with OncoPlex testingProstate >500 tumors (STTR abstractor) + large volume

of historic data

How is data being stored and provided to faculty?

Clinical data from Caisis, TCGA, and other data sources are organized into event tables to provide a flexible and extensible structure for referencing patient information. During this data processing, fields are checked for misspellings, inconsistent terminology, and inaccurate or missing data (e.g. post-mortem treatments, synonymous or abbreviated drug names). Molecular profiles are linked through a unique patient/sample barcode and stored in gene-level matrices. Our current data processing pipeline incorporates copy number variation, structural variation, gene fusions, mutations, expression levels, methylation, and protein abundance measures originating from TCGA, UW Oncoplex, and other high-throughput technologies. TCGA datasets are available for anyone to explore within Oncoscape. Now, it is time for the STTR community (you) to begin to ask the research questions and generate new, exciting hypotheses.

Natural Language ProcessingCurrently ~65-80% of data elements needed for

clinical and translational research are in unstructured, narrative form. STTR is working with CIT Informatics to minimize manual clinical data abstraction across the Consortium. NLP pilots are ongoing to assess the feasibility of automated clinical data extraction.

Project Focus: The aim is to automatically extract vital data elements (i.e. histology, TNM staging...etc.) and allow data to be manually verified by abstractors.

Data Source: For the pilot, data will be pulled from pathology reports for lung cancer.

Contact Emily Silgard for more information.

Mail stop c3-168 1100 FairvieW ave. n., po Box 19024 seat tle, Wa 98109-1024 206.667.6661 st trcancer.org

Screenshot of Oncoscape (a computational biotool for STTR members in a secure portal which allows interactive, in-browser data analysis & visualization of clinical & molecular data).

*www.Oncoscape.STTRcancer.org*

Fall 2015S O L I D T U M O R T R A N S L AT I O N A L R E S E A R C H

2016 oncology recognition DayWe Want to Celebrate You

Last year, STTR hosted the first Oncology Recognition Day. On that day, we honored staff from UW Medicine, Fred Hutch and Seattle Cancer Care Alliance who work tirelessly to support the work being conducted at each of these institutions.

Teams came together to share projects they created to improve their work flow, clinical care or work systems.

Process/Systems Improvement Competition

With the support of leadership at all three institutions, we will be hosting a second Oncology Recognition Day and will be announcing another round of our Process/Systems

Improvement Awards. It is time to begin to identify opportunities to problem solve, build community and share best practices that may be useful to other groups. Email with details to come fall 2015.

STTR Faculty RetreatOn June 26th, 2015 over 200 STTR members attended our first

Faculty Retreat and participated in sessions on immunotherapy, genomics, public health and computational oncology. The day was filled with opportunities for faculty to engage with one another, including a poster session highlighting our 2014 STTR Grant Winners, as well as representatives from Development, Communications and HIDRA. Afternoon breakout sessions included topics such as Jr. Investigators Taking Big Risks, Novel Therapeutics

and Computational Oncology: Analysis and Design.

We were honored to have Dr. José Baselga, Physician-in-Chief and Chief Medical Officer at Memorial Sloan Kettering Cancer Center, participate throughout the day and close our event with his keynote address. We are grateful to all who presented and attended this event, thrilled with the new collaborations sparked through the sessions, and excited by the new technologies, services and funding opportunities announced at the retreat.

Mail stop c3-168 1100 FairvieW ave. n., po Box 19024 seat tle, Wa 98109-1024 206.667.6661 st trcancer.org

Chad Toledo discussing his work with Dr. Maciej Mrugala during the Poster Session and coffee break.

Dr. Stan Riddell presenting on the use of engineered CAR-T cells for solid tumors.

(LEFT) Highlights of the award ceremony and poster session during the 2014 Oncology Recognition Day.

congratulations 2015 grant Winners! EARLY PHASE CLINICAL RESEARCH SUPPORT ($35,000) AWARDS

A Phase I Study of Nortriptyline and Paclitaxel for Relapsed/Refractory Small Cell Lung and Genitourinary Carcinomas - Drs. Robert (Bruce) Montgomery, Jonathan Wright, and David MacPherson

A Pilot Study of MPDL-3280A (PD-L1 Antibody Therapy and Hypofractionated Image-guided Radiotherapy (HIGRT) in Patients with Metastatic Non-Small Cell Lung Cancer - Drs. Ramesh Rengan, Sylvia lee, and Edus (Hootie) Warren

A Neoadjuvant Clinical Trial to Assess the Effectiveness of Intense Combinational Targeting of AR Signaling to Eradicate Prostate Carcinoma - Drs. Michael Schweizer and Peter Nelson

Feasibility of Assessing Drug Response Using Presage’s CIVO Device in Soft Tissue Sarcoma Patients - Drs. Seth Pollack and Ernest (Chappie) Conrad

TRANSFORMATIVE TEAM ($50,000) AWARDS

Developing TIL Therapy for Localized Urothelial Bladder Cancer - Drs. A. McGarry Houghton, Sylvia lee, Evan Yu, and Jonathan Wright

Tumor Infiltrating Lymphocytes and Survival from Oral Cancer - Drs. Chu Chen, Harlan Robins, and Pawadee lohavinchbutr

Interrogating Chemoresistance in Small Cell Lung Cancer through Study of Circulating Tumor Cells - Drs. David MacPherson and Keith Eaton

Bioassay for Pancreas Cancer Circulating Tumor Cells (CTC) - Drs. Sunil Hingorani and Daniel Chiu

Treatment Stratification for Metastatic Prostate Cancer: Enrichment for Heritable Defects in DNA Repair - Drs. Peter Nelson, Heather Cheng, Robert (Bruce) Montgomery, Colin Pritchard, and Hamid Bolouri

ONCOSCAPE BIOSPECIMEN UTILIZATION ($100,000) AWARDS

Small Nuclear RNAs in Triple-Negative Breast Cancer Progression - Drs. Robert Bradley, Peggy Porter, and Heidi Dvinge

Integration of a Prognostic Gene Signature and UW Oncoplex Test to Define the Mutational Landscape of Head and Neck Cancer (HNC) with Poor Survival - Drs. Eduardo Mendez, Chu Chen, and Justin Guinney

Mutational Profiles Dictate Immune Responses in NSCLC - Drs. A. McGarry Houghton and Martin McIntosh

Minimally-Invasive Assessments of Tumor Molecular Composition for Precision Diagnostics and Monitoring Treatment Responses - Drs. Peter Nelson, Michael Schweizer, Robert (Bruce) Montgomery, Hamid Bolouri, and Colin Pritchard

TRANSLATIONAL RESEARCH TEAM MEETING ($12,000) STIPEND

NWBioTrust specimen collection: Colorectal, Head and Neck, and Pancreas

Data abstraction support: Lung, Prostate, and Sarcoma

Rapid autopsy developement: Bladder

Fall 2015S O L I D T U M O R T R A N S L AT I O N A L R E S E A R C H

Mail stop c3-168 1100 FairvieW ave. n., po Box 19024 seat tle, Wa 98109-1024 206.667.6661 st trcancer.org

Fall 2015S O L I D T U M O R T R A N S L AT I O N A L R E S E A R C H

Advocating for Precision MedicineIn July, STTR leaders, Dr. Eric Holland and Desert

Horse-Grant met with Dr. Jo Handelsman, the Associate Director of Science at the Office of Science and Technology Policy, to discuss the future of precision medicine, Fred Hutch developments in cancer research, the new biotool, Oncoscape, and ways to reduce the cost of cancer treatments. They were accompanied by Fred Hutch consultant, Jennifer Giffith (Senior Vice President, Petrizzo Group) and Rhonda Curry (Director, Communication and Government Relations, Fred Hutch).

Media MentionsThe University of Washington Medical Center/Seattle Cancer Care Alliance ranked No. 5 in cancer among top hospitals in the United States, U.S. News & World Report. Read more >http://health.usnews.com/best-hospitals/rankings/cancer

Congratulations to the phenomenal Doctors and Nurse Practitioners from UW Medicine, Seattle Cancer Care Alliance and Fred Hutch who made Seattle Met Magazine’s Top Doctors and Nurses of 2015. Read more > http://www.seattlemet.com/articles/2015/8/4/top-doctors-and-nurses-2015-how-we-made-the-list

Weight loss + vitamin D = Reduced inflammation? A recent study by Dr. Catherine Duggan of the Public Health Sciences Division at Fred Hutch found weight loss plus vitamin D supplementation reduces inflammatory markers related to cancer and chronic disease in overweight postmenopausal women. Read more >http://www.fredhutch.org/en/news/releases/2015/06/weight-loss-plus-vitamin-d-reduces-inflammation.html

Dr. Robins’ “game changer” is speeding immunotherapy research at Fred Hutch & Adaptive Biotechnologies. Read more > http://www.fredhutch.org/en/news/center-news/2015/08/pairseq-fast-tracks-immunotherapy.html

Fertility after cancer: are all cancer patients receiving counseling on preserving fertility? Read more >http://bit.ly/1N8Q66f

Congratulations to Dr. Amanda Paulovich for winning The Human Proteome Organization’s 2015 Distinguished Achievement in Proteomic Sciences Award! Read more >http://www.fredhutch.org/en/news/center-news/2015/08/good-news-paulovich-coffey-petersdorf.html

Dr. Peter Nelson to lead $1M study of metastatic prostate cancer. Read more > http://www.fredhutch.org/en/news/center-news/2015/08/good-news-nelson-prentice.html

Mail stop c3-168 1100 FairvieW ave. n., po Box 19024 seat tle, Wa 98109-1024 206.667.6661 st trcancer.org

(ABOVE) Dr. Jo Handelsman

(RIGHT) Dr. Eric Holland and Desert Horse-Grant during their trip to the White House.

Fall 2015S O L I D T U M O R T R A N S L AT I O N A L R E S E A R C H

Ongoing Translational Research Meetings

Bladder: 3rd Thursday, 4pm

Colorectal: 4th Tuesday, 3pm

Glioma Working Group: Quarterly (Next - Sept. 29, 3pm)

Head & Neck: 3rd Monday, 4pm

Lung: 3rd Thursday every other month, 4pm (Next - Nov)

Pancreas: 4th Monday, 5pm

Prostate: Thursdays, 4pm (research meeting), 5pm (lecture)

Sarcoma: TBA - Mid October

Email us at STTRCancer@fredhutch.org for further information.

Join sttr obliteride team in 2016Join us next year! The STTR-HB All Stars continues to grow in number of participants and miles ridden. This year, our

team tripled in size with members participating in the Kid’s Ride, 10-mile and 50-mile races. The team included members of STTR, Human Biology Division and their family and friends. In order to reach (and exceed) their fundraising goals, team members conducted multiple bake sales, a barbeque, a raffle with items donated from Patagonia and advertised using social media outlets. We’ve had a blast and are already looking forward to the fun next year will bring.

st trcancer.org

(LEFT) STTR-HB All Stars represent at the Kid’s Ride.

(RIGHT) 2015 STTR-HB All Stars 50 Mile Riders (from top left):

Top row - Andrea Brocato, Daniel Krenn, Rachel Galbraith, Thomas Donn, Jalle Gebisa

Bottom row - Cathy Lin, Gretchen Heinrich, Regan Smith

Questions? Email us at STTRCancer@fredhutch.org.