Gülden Olgun

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Problem DefinitionSitutation of the non-renal patients after

bypass surgeryIncrease in the serum creatinine

concentration or azotemia(blood urea nitrogen[BUN])

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OutlineProblem Definition IntroductionFeature SelectionMethodology for preop/postopAnalysis of the R-Project and Knime ResultsDemoConclusion

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Acute Renal FailureAbrupt or rapid decline in renal filtration

functionRise in serum creatinine concentration

Rise in blood urea nitrogen – BUN- concentration

Have high Potassium level

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Creatinine - BUNCreatinine

Breakdown product of creatineNormal results*: adults W : 0.66 – 1.09 mg/dL

M(<50 age): 0.84 – 1.25 mg/dL

(>50 age): 0.81 – 1.44 mg/dL

BUNBreakdown product of proteinNormal results*: adults W- M : 7.9 – 21 mg/dL > 60 age : 8 – 23 mg/dL

5* http://merkezlab.erciyes.edu.tr/biyokimya/referans.htm

Coronary Artery Bypass GraftReroute the blood flow through a new artery Requires open-chest surgeryIncrease the BUN, creatinine

Cause acute renal failure

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Feature Selection(Cardio Dataset)Renal Features

PreStatus5(70): Preop. acute renal failureRenalYetmezlik(85)Renal(751): renal failure, requirement of dialysisMortalitePrimerNeden12(842): Mortalite due to

renal failure Bypass Features

PeriferikArterHastalık(92)OperasyonGrup0(358): Coroner Bypass Surgery

Creatinine FeaturesSonPreopKreatinin(86)

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Feature Selection(Laboratuar dataset)Dosya_NoPreoperatif/PostOperatifBUNKreatininUrik_AsitSodyumPotasyum

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MethodologyPreOperation:

10 fold Decision TreeSVMNaive Bayes Learner

PostOperation:Bypass patients

SVM Decision Tree

Non-bypass patients SVM Decision Tree

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PreprocessPreprocess for preoperation

Use patients’ ids which occur in both dataset(cardio and lab) -> R project

Preprocess for post operation Get ids of patients whose operation is bypass

and non-bypass

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Knime(Preoperation)

11Decision tree for PreStatus5 (Acute Renal Failure before bypass surgery)

R-Project(Preoperation)

12Decision tree for PreStatus5 (Acute Renal Failure before bypass surgery)

R-Project 1) root 9739 476 False (0.0337817024 0.9511243454 0.0150939522) 2) SonPreopKreatinin< 2.5 9592 356 False (0.0342994162 0.9628857381

0.0028148457) 4) OperasyonGrup0= 353 158 False (0.4419263456 0.5524079320

0.0056657224) 8) SonPreopKreatinin< 1.5 348 157 False (0.4482758621 0.5488505747

0.0028735632) 16) RenalYetmezlik< -0.5 273 117 (0.5714285714 0.4285714286

0.0000000000) * 17) RenalYetmezlik>=-0.5 75 1 False (0.0000000000 0.9866666667

0.0133333333) * 9) SonPreopKreatinin>=1.5 5 1 False (0.0000000000 0.8000000000

0.2000000000) * 5) OperasyonGrup0=False,True 9239 198 False (0.0187249702

0.9785691092 0.0027059206) 10) RenalYetmezlik< 1.5 9207 178 False (0.0187900510 0.9806668839

0.0005430651) * 11) RenalYetmezlik>=1.5 32 12 True (0.0000000000 0.3750000000

0.6250000000) * 3) SonPreopKreatinin>=2.5 147 27 True (0.0000000000 0.1836734694

0.8163265306) *

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R-Project(Postoperation)

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Normal results: Sodyum Adults: 136-146 BUN Adults: 7,9 - 21

Knime(Postoperation)For Bypass Patients

Normal Results: Potassium -> Adults: 3.5 – 5.1 mmol/L

BUN Adults: 7,9 - 21

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Knime(Postoperation)For bypassPatients(without BUN)

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KnimePreoperation:

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KnimePostoperation

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KnimeFor non-bypass patients

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BUN-Creatinine-Potassium-Sodium

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Bypass patients

Non-bypas patients

ConclusionHigh correlation between OperasyonGrup0

and PreStatus5Sodium and BUN relation in bypass patients

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