guideline influenza 2011
TRANSCRIPT
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Clinical Practice Guideline
for Influenza
Clinical Practice Guideline
for Influenza
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(CPG)
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- 1-3 ( 5 )
- 1 - 5 ( 7 )- 3
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70
30 .
-1.
Chest X-ray 1.
5 30 / 24 /
- / - fine crepitation, bronchial breath sound- O2sat. pulse oximeter (SpO2) room air 90%- Chest X-ray
2.
3. 4. 48 . 5. 90 /
48
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- -
-2.
-
- -
- - - - 48 . - - -
2.1 (1)
5 - - (2)
48
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.
-1.
- 1. : mask 2. : ,
(cohort ward) (cohort building)-
(www.moph.go.th)
-2. 2.1
- respiratory droplets ( ) 1-2 surgical mask
- close contact
(6)
- airborne nebulization, respiratorytherapy, bronchoscopy N95 mask
2.2 1-2
surgical mask
2.3 2-6 .
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3.2 surgical mask 1.
, - 2. 3. 4. mask
5. mask , 6. surgical mask 1
3.3 nasopharyngeal swab throat swab
surgical mask goggle ()
. Influenza virus- Influenza-like illness (ILI)(3)
- nasal swab nasopharyngeal aspirate throat swab tracheal
aspirate- Influenzavirus RT-PCR - rapid test
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. Oseltamivir
-1. - 48 .
5 - Oseltamivir suspected(4) confirmed cases(5)
1. 2. 3. 48 .
4. - Oseltamivir 2 5
-2. -
(pre-exposure) (post-exposure)-
-3. Oseltamivir3.1 ( 5 )
75 . 2
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(0-1 ) 2 ./. 2 (0-1 )1 ./. 2
3. 1. Creatinine clearance 10-30 ./ 75 .
75 . 2. CAPD : 75 . 30 .
3. Hemodialysis : 75 . 30 . Hemodialysis
3.2 Oseltamivir- :
- -
3.3 - 25
3.4 ()3.5 Zanamivir (inhaled)
oseltamivir oseltamivir
1. oseltamivir
2
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1.
1. : (BMI) = (.) / (.)2
30; : / 140
2. 14 3.
-
- - (/ HIV CD4 350/uL, , )
- ()
- - 18 ( Reye syndrome)2.
- 2 65 -
- HIV CD4 350/uL-
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5. Confirmed case RT-PCR
6. Close contact 1-2 mask mask
()
1. ()
2.
3.
4. 5.
6. 7.
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6.
2 2 65
www.moph.go.th . 1422
24
. 02-245-8106, 02-246-0358
02-354-1836
1. 2. 6
2 6 - 2 65 3. secondtrimester ( 6)
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Oseltamivir
Oseltamivir Suspension
10 ./. 30 . Oseltamivir cap 75 . 4
*1. 2. geometric proportion
3. 4. 30 .5.
10 * 100 .
Sucrose 80 Sodium benzoate 0.1
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Oseltamivir phosphate Roche2 capsule 75 . (powder for oral suspension) 25 . 12 ./. oseltamivir suspension capsule
1. Winiarski AP, Infeld MH, Tscherne R, Bachynsky M, Rucki R, Nagano-MateK. Preparation and stability of extemporaneous oral liquid formulations of oseltamivir
using commercially available capsules. J Am Pharm Assoc 2003; 47 (6): 747-55). US Cherry syr Ora-Sweet SF 15 ./. (5 ) 35 (25 ) 5
2. Roche AHFS DRUG INFORMATION 2009
(raw material capsule) sodium benzoate 15 ./. (25 ) 3 (5 ) 6
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