Published Ahead of Print 4 January 2013. 10.1128/AEM.03681-12.

2013, 79(6):1803. DOI:Appl. Environ. Microbiol. Katrin Kellner, Robert M. Plowes and Ulrich G. MuellerQuinn S. McFrederick, Jamie J. Cannone, Robin R. Gutell, Rather than the RuleHymenopteran Hosts Is the Exception Specificity between Lactobacilli and

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Specificity between Lactobacilli and Hymenopteran Hosts Is theException Rather than the Rule

Quinn S. McFrederick,a Jamie J. Cannone,b Robin R. Gutell,b Katrin Kellner,a Robert M. Plowes,c Ulrich G. Muellera

Section of Integrative Biology, University of Texas at Austin, Austin, Texas, USAa; The Institute for Cellular and Molecular Biology and the Center for Computational Biologyand Bioinformatics, The University of Texas at Austin, Austin, Texas, USAb; Brackenridge Field Laboratory, University of Texas at Austin, Austin, Texas, USAc

Lactobacilli (Lactobacillales: Lactobacillaceae) are well known for their roles in food fermentation, as probiotics, and in humanhealth, but they can also be dominant members of the microbiota of some species of Hymenoptera (ants, bees, and wasps).Honey bees and bumble bees associate with host-specific lactobacilli, and some evidence suggests that these lactobacilli are im-portant for bee health. Social transmission helps maintain associations between these bees and their respective microbiota. Todetermine whether lactobacilli associated with social hymenopteran hosts are generally host specific, we gathered publicly avail-able Lactobacillus 16S rRNA gene sequences, along with Lactobacillus sequences from 454 pyrosequencing surveys of six otherhymenopteran species (three sweat bees and three ants). We determined the comparative secondary structural models of 16SrRNA, which allowed us to accurately align the entire 16S rRNA gene, including fast-evolving regions. BLAST searches and maxi-mum-likelihood phylogenetic reconstructions confirmed that honey and bumble bees have host-specific Lactobacillus associates.Regardless of colony size or within-colony oral sharing of food (trophallaxis), sweat bees and ants associate with lactobacilli thatare closely related to those found in vertebrate hosts or in diverse environments. Why honey and bumble bees associate withhost-specific lactobacilli while other social Hymenoptera do not remains an open question. Lactobacilli are known to inhibit thegrowth of other microbes and can be beneficial whether they are coevolved with their host or are recruited by the host from envi-ronmental sources through mechanisms of partner choice.

Lactobacillus is the largest genus of lactic acid bacteria (LAB),containing species that are well known for their roles in food

production and human health (1). Lactobacilli convert sugars tolactic acid and other acids, and some species are used in foodfermentations to preserve foods, contribute flavor, or inhibit thegrowth of other bacteria (2). Other lactobacilli are used as humanprobiotics; for example, L. reuteri protects children from rotavirusgastroenteritis (3). Lactobacillus is of obvious importance to hu-mans for both economic and health reasons.

Lactobacilli also associate with diverse nonhuman animals,and there is evidence that some lactobacilli can protect these hostsfrom pathogens (4, 5). For example, Lactobacillus reuteri is foundin the gastrointestinal tracts of pigs, rodents, chickens, and hu-mans and aids in protection of the host from pathogens (6). Lac-tobacillus plantarum is one of the five dominant bacterial phylo-types found in Drosophila melanogaster intestinal tracts (7),promoting larval growth in low-nutrient medium (8). A mixtureof LAB, including Lactobacillus species, help protect honey beelarvae from Paenibacillus larva and Melissococcus plutonius, thecausative agents of American and European foulbrood, respec-tively (9, 10). The Lactobacillus phylotypes Firm4 and Firm5, inconjunction with other members of the bumble bee microbiota,protect bumble bee workers from the trypanosome pathogenCrithidia bombi (11, 12). LAB have also been hypothesized to playa role in fermenting pollen stored by honey bees, thereby protect-ing the stored bee bread from spoilage (13), although firm evi-dence for this hypothesis is still lacking.

Several authors suggested recently that the relationships be-tween honey and bumble bees (corbiculate apids) and their mi-crobiotae, both of which include related Lactobacillus phylotypes,have been shaped by coevolutionary processes (10, 14, 15). Ourrecent phylogeny (16), based on a short fragment of the 16S rRNAgene, agreed with suggestions that the Firm3, Firm4, and Firm5

honey bee- and bumble bee-associated Lactobacillus phylotypesare host specific, which suggests that between-species transmis-sion of these phylotypes is uncommon or absent (16). Horizontaltransmission has not been excluded, but both honey and bumblebees can acquire microbes through within-colony social contact(11, 17). In contrast, solitary and primitively eusocial sweat beesassociate with lactobacilli related to those that occur on flowers(16). It is currently unknown whether sociality per se or someunique aspect of corbiculate apid biology maintains the relation-ship between honey and bumble bees and their host-specific lac-tobacilli.

Here we explore the host specificity of lactobacilli that associatewith hymenopteran hosts that exhibit a range of social structures.First, we used very accurate comparative secondary structuremodels as templates to create a larger set of 16S rRNA structuremodels that represent all of the major forms of structural diversitypresent in the primary groups of lactobacilli. Second, we usedthese structure models to construct a comprehensive and highlyaccurate alignment of full-length or nearly full-length 16S rRNAgene sequences. To determine whether host specificity is commonin associates of insects that live in large societies or is limited toassociates of corbiculate apids, we constructed two additionalalignments that included 16S-amplicon 454-pyrosequencing sur-

Received 28 November 2012 Accepted 2 January 2013

Published ahead of print 4 January 2013

Address correspondence to Quinn S. McFrederick, quinnmcfrederick@gmail.com.

Supplemental material for this article may be found at http://dx.doi.org/10.1128/AEM.03681-12.

Copyright © 2013, American Society for Microbiology. All Rights Reserved.

doi:10.1128/AEM.03681-12

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veys of several bee and ant species. We then used these structure-based alignments to reconstruct the phylogenetic history of thegenus Lactobacillus.

MATERIALS AND METHODSFull and nearly full-length Lactobacillus 16S rRNA gene sequences. Toobtain a comprehensive representation of this diverse genus, we down-loaded publicly available, full-length or nearly full-length sequences of the16S rRNA gene. First, we searched NCBI’s nucleotide database (18) forcomplete Lactobacillus 16S rRNA gene sequences. Next, we searched theRibosomal Database Project (RDP [19]) for Lactobacillus 16S sequenceslonger than 1,200 bases and of good quality, as designated by RDP. Toinclude sequences from bee-associated lactobacilli, we downloaded asso-ciated sequences from NCBI PubMed entries of bee-bacterial studies andadditionally searched NCBI’s nucleotide database for bee-associated lac-tobacilli. To avoid redundant sequences and obtain a more tractable rep-resentation of the genus, we clustered sequences of �97% sequence sim-ilarity with the program CD-HIT (20). Since this clustering may haveeliminated some sequences from type strains that were represented bylonger sequences that shared �97% sequence identity with the type strainsequence, we obtained the accession numbers of Lactobacillus type speci-mens from RDP. We then searched our file for the accession numbers ofthese type sequences and added missing sequences back into the align-ment. We additionally searched NCBI taxonomy for Lactobacillus speciesand added reference sequences (21), when available, for the species thatwere missing in our alignment. Finally, we searched the list of prokaryoticnames with standing in nomenclature (22) to verify that our alignmentdid indeed contain representatives from all described lactobacilli. This setof 16S rRNA sequences included identified, cultured, unidentified, anduncultured Lactobacillus species. As outgroups, we added sequences from14 bacterial species from across the Bacilli but with emphasis on the Lac-tobacillales. To investigate diversity of paralogous gene copies within agenome, we included all 16S rRNA gene copies from whole-genome se-quence of five ingroup species and one outgroup species. Our final align-ment contained 19 outgroup sequences (from 14 species), 158 sequencesfrom undescribed or unidentified Lactobacillus species, and 224 sequencesfrom 160 named, but not necessarily published, Lactobacillus species for atotal of 401 sequences.

Partial and complete 16S rRNA gene sequences, including hyme-nopteran associates. To integrate 454 pyrosequencing data into the align-ment of complete or nearly complete full-length sequences, we built asecond alignment spanning the length of the 16S rRNA gene. We codedthe five prime and three prime ends of the 454 sequences as missing data.The effect of missing data on phylogenetic reconstructions is an ongoingresearch area with no simple consensus (23, 24). We therefore planned tointerpret the results of the partial and complete 16S alignment with miss-ing data with caution.

We started with the 401 sequences described above and added se-quences from three separate 16S rRNA-amplicon 454-pyrosequencingstudies of bacteria associated with Hymenoptera: the sweat bees (Halicti-dae) Augochlora pura, Halictus ligatus, and Megalopta genalis (16); an at-tine fungus-growing ant, Mycocepurus smithii (K. Kellner et al., unpub-lished); and the fire-ants, Solenopsis invicta and Solenopsis geminata (25;R. M. Plowes et al., unpublished). We previously published the halictiddata (16), which we obtained from one wild nest of A. pura (Virginia), onelaboratory nest of H. ligatus (Virginia), and two wild nests of M. genalis(Barro Colorado Island, Panama). We also sampled one colony of M.smithii in the wild in Gamboa, Panama, and then brought the nest into thelaboratory and sampled it again 6 months later. We collected S. invicta andS. geminata-complex samples in their native range in Argentina and intheir invasive range in Taiwan, Texas, Florida, and California (Plowes etal., unpublished). These data represent subsets of data sets from previousor forthcoming publications (see, for example, references 16 and 25). Thethree studies used the same 16S rRNA primers: Gray28F 5=-GAGTTTGATCNTGGCTCAG and Gray519r 5=-GTNTTACNGCGGCKGCTG,

which span V1-V3 in the secondary structure of 16S rRNA. V1-V3 arevariable regions that have been shown to accurately differentiate closelyrelated lactobacilli (26). Research and Testing Laboratories (Lubbock,TX) generated the 454 sequence for the three studies at different times.The sweat bee- and Mycocepurus-associated reads were 454 sequencedforward from Gray28f, while the Solenopsis-associated sequences were 454sequenced reverse from Gray519r (these later sequences were reversecomplemented for our analysis).

We used previously described pipelines to denoise and otherwise qual-ity check the 454 16S rRNA reads (16, 25). The sweat bee-associated Lac-tobacillus sequences were depleted of low-quality sequences and chimeras,denoised, and assigned to phylotype as described in McFrederick et al.(16). The Mycocepurus- and Solenopsis-associated bacterial sequenceswere processed in the program mothur (27). First, we denoised the datawith the shhh.flows command. We then removed any sequences withmismatches in the primer binding site or the barcode, or homopolymerruns of over eight bases, and removed primers and barcodes from thesequences. To remove chimeric sequences, we used the chimera.uchimecommand, and deleted the detected chimeras. Next, we ran BLASTsearches against a 16S rRNA database curated by the Medical BiofilmResearch Institute (MBRI; Lubbock, TX). We selected sequences with topBLAST hits against the MBRI database of at least 90% sequence identity toLactobacillus sequences. We chose a minimum of 90% sequence identityin order to include novel Lactobacillus sequences, while keeping in mindthat any sequences that do not belong in the genus Lactobacillus should falloutside of our ingroup in our phylogenetic analysis. As a validation of ourBLAST searches, we ran additional BLAST searches of the 454 sequencesagainst the entire nucleotide collection at NCBI. Next, to maximize thephylogenetic signal of the short 454 reads, we removed 454 sequences thatwere �350 bases long. We then clustered sequences of 97% or greatersequence identity with the program CD-HIT (20). After quality controland clustering, we added 84 sweat bee-associated, 79 Mycocepurus-asso-ciated, and 56 Solenopsis-associated sequences to our alignment, for a totalof 620 sequences in the entire alignment.

The hymenopteran hosts included here vary widely in both geographyand natural history. Augochlora pura and H. ligatus both live in NorthAmerica, but A. pura is a solitary bee that nests in rotten logs (28), whereasH. ligatus is a primitively eusocial halictid that forms small colonies in thesoil (29). Megalopta genalis is a socially polymorphic, neotropical sweatbee that builds nests in decaying branches found in the forest understory(30, 31). Mycocepurus smithii is a neotropical non-leaf-cutting fungus-growing ant that forms colonies with an average of 77 workers in repro-ductive nests in Puerto Rico (32) but can also form much larger singlecolonies that occupy more than one nest in the Brazilian Amazon (33, 34).In contrast, S. invicta is originally from South America but has becomewidespread in its invasive range and can reach colony sizes of 220,000individuals (35, 36). Solenopsis geminata variants have been introduced tomany locations, including Taiwan and possibly Florida (H. Axen, unpub-lished data).

Partial 16S rRNA gene sequences, including hymenopteran associ-ates. To investigate the phylogenetic utility of the short 454-pyrosequenc-ing data, we created a third alignment spanning positions 30 to 517 in theE. coli 16S rRNA gene sequence. We used the entire length of the 454 dataand trimmed the 401 full-length sequences to span only the regions over-lapping the 454 pyrosequencing reads. By creating three separate align-ments, we were able to compare results and determine differences in thephylogenetic reconstructions based on partial versus full length versus acombination of partial and complete 16S rRNA sequences.

Sequence alignment and RNA secondary structure. We used covari-ation analysis to identify RNA secondary structure that is common to a setof sequences that are known to have the same function and higher-orderstructure (37). Covariation analyses identify all types of canonical andnoncanonical base pairs with a set of nucleotides that covary with oneanother, regardless of their proximity to other structural elements (38,39). Approximately 97% of the base pairs, including all of the noncanoni-

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cal base pairs, pseudoknots, and other irregular structural elements in thecomparative 16S rRNA secondary structure models are in the crystalstructure of the ribosomal subunit (40). The strength of the covariationfor each predicted base pair has been quantified and used as a confidencerating for each base pair (http://www.rna.ccbb.utexas.edu/SAE/2A/nt_Frequency/BP/). Given this very high accuracy, as gauged with high-resolution crystal structures, we are most confident that all or nearly all ofthe base pairs in the comparative structure models for the rRNAs fromdifferent organisms are correct, including all of the 16S rRNA secondarystructure models for the genus Lactobacillus (for a complete discussion ofcovariation analysis, see File S1 in the supplemental material).

The accuracy of our predicted secondary structure models are directlyassociated with the quality of the sequence alignment. Better alignmentsfacilitate better comparative structure models. Moreover, vice versa, veryaccurate comparative structure models are the basis for the juxtapositionof nucleotides that are components of similar and analogous structuralelements, especially in highly variable regions that can have large variancesin the number of nucleotides with little or no sequence identity. Thus, oursecondary structure-based alignments do not attempt to maximize se-quence identity a priori. Instead, they attempt to maximize the alignmentof similar structural elements.

After the 16S rRNA sequences were semiautomatically aligned withthe template-based alignment program CRWAlign (41), we refined thealignment manually with the alignment editor AE2 (developed by T.Macke, Scripps Research Institute, San Diego, CA [42]). This tool wasdeveloped for Sun Microsystems (Santa Clara, CA) workstations runningthe Solaris operating system. The manual alignment process utilizes theCRWAlign program to identify nucleotides in a column that might notmap to the same locations in the secondary and tertiary structure. A visualinspection of the alignment determines if these flagged nucleotides shouldbe realigned. If necessary, this is done manually with the AE2 alignmenteditor. For regions of the alignment with high sequence similarity andminimal variance in the number of nucleotides, the information in theprimary structure is sufficient to align sequences with confidence. In con-trast, for more variable regions in closely related sequences or betweenmore distantly related sequences, a high-quality alignment can only beproduced when secondary and/or tertiary structure information is in-cluded.

Secondary structure diagrams. Secondary structure diagrams weregenerated after the first secondary structure model was derived with com-parative methods. Although the Comparative RNA Web (CRW) site(http://www.rna.ccbb.utexas.edu/) contains more than 200 16S rRNAsecondary structure diagrams that sample the diversity within the Bacte-ria, we generated 47 secondary structure diagrams for the present study:38 from taxa representing all of the major phylogenetic groups of Lacto-bacillus and nine from related organisms. We generated the secondarystructure diagrams with the interactive secondary structure programXRNA (written in the C programming language for Sun Microsystemsworkstations running the Solaris operating system by B. Weiser and H.Noller, University of California, Santa Cruz, CA). All structure diagramsare available as online supplemental files at http://www.rna.ccbb.utexas.edu/.

Phylogenetic analyses. To reconstruct the phylogenetic history of thelactobacilli, we conducted separate maximum-likelihood analyses on ourthree alignments. We first determined that GTR�I�� was the most ap-propriate model of sequence evolution for each of our alignments usingthe Akaike Information Criterion (AIC) in Modeltest 3.7 (43) and PAUP*4b10 (44). We then ran 20 independent search replicates on each align-ment in the program GARLI 2.0 (45), with the genthreshfortopoterm,stopgen, and stoptime settings set to 10,000,000. We allowed the programto estimate all parameter values during the runs. To assess branch supportwe conducted 100 bootstrap pseudoreplicates on each alignment, using agenthreshfortopoterm setting of 5,000,000. We used Mesquite (46), tocalculate patristic distances across the entire tree. To calculate divergence,we used the branch info tool in Mesquite (46) to measure the distance

from the base of monophyletic groups of hymenopteran associates to themost recent common ancestor with their closest relatives.

Data availability. We deposited the 84 sweat bee-associated, 79 My-cocepurus-associated, and 56 Solenopsis-associated sequences in the ge-netic sequence database at the National Center for Biotechnical Informa-tion (NCBI GenBank accession numbers KC354148 to KC354367).

RESULTS

Phylogenetic reconstructions of our three 16S rRNA gene sequencealignments resulted in similar clade structure for all trees (Fig. 1 and 2;see also Fig. S1 and see Table S1 in the supplemental material forsimple sequence statistics for all alignments). The phylogeny basedonly on full-length 16S rRNA sequences (Fig. 1) was in nearly com-plete agreement with the phylogeny based on a combination of partialand complete 16S rRNA sequences (Fig. 2). The phylogeny based ononly partial 16S sequences (see Fig. S1 in the supplemental material),however, differed in the branching patterns between and withinclades compared to the full-length phylogeny, but the terminal cladecomposition remained stable. Sequence alignments and detailedphylogenetic trees are available at TreeBase (http://purl.org/phylo/treebase/phylows/study/TB2:S13670), and a detailed version ofFig. 2 with bootstrap support values and taxon labels is available in theonline supplemental files (see Fig. S2 in the supplemental material).

16S rRNA secondary structural models. We created second-ary structural models from 16S rRNA gene sequences of 38 lacto-bacilli and nine other Firmicutes (see File S1 in the supplementalmaterial). In addition, the extent of primary and secondary struc-ture conservation for 608 16S rRNA sequences representing theentire lactobacilli genus was mapped onto a L. acidophilus second-ary structure diagram (Fig. 3). The first hairpin stem and loopfrom the five prime end of the molecule (the V1 region) was themost variable region in Lactobacillus 16S structure. Our structuralmodels suggest that next generation sequencing surveys of bacte-rial communities aimed at elucidating the diversity of Lactobacil-lus should use primers targeting the V1 region.

Full-length 16S rRNA gene phylogeny. Our maximum-likeli-hood analysis of full- or nearly full-length 16S rRNA gene se-quences recovers six major monophyletic clades, which we iden-tify in accordance with previous studies: L. salivarius, L. delbrueckii(acidophilus), L. casei, L. buchneri, L. plantarum, and L. reuteri(Fig. 1) (47–50). The maximum-likelihood bootstrap support val-ues for these clades varied greatly: the L. salivarius and L. reutericlades showed moderate support (82 and 85%, respectively),while other clades showed weak support at their deepest nodes.The deeper branches connecting these major clades uniformlyshowed little support. The clade containing the greatest number oftaxa and the greatest sequence diversity was the L. delbrueckii(acidophilus) clade, which was comprised of 160 taxa and covereda maximum patristic distance of 1.21, out of a global maximum of1.51 across the entire tree (Table 1).

Partial and complete 16S rRNA gene phylogeny, includinghymenopteran associates. The phylogenetic trees determinedfrom the analysis of the partial and complete 16S rRNA alignmentand the full-length 16S rRNA alignment were very similar (Fig. 1and 2). The main difference between the two phylogenies was theplacement of the reuteri clade. The reuteri clade was sister to theplantarum clade in the full-length phylogeny (Fig. 1), whereas inthe partial and complete phylogeny the members of the reutericlade were reconstructed paraphyletic as a series of branching lin-eages leading to the monophyletic L. delbrueckii (acidophilus)

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clade (Fig. 2). Clade memberships and within-clade branchingpatterns were very similar between the full-length and the partialand complete phylogenies, as were the bootstrap support values(Fig. 1 and 2).

Of the Hymenoptera-associated sequences, only the honey andbumble bee-associated Firm3 and Firm4 (F3 and F4 sensu [51])clades were host specific and highly diverged from other lactoba-cilli (Fig. 4). Firm5 also formed a monophyletic group, but was notas diverged from other lactobacilli as Firm3 and Firm4 (Fig. 2 and4). In addition, two sequences from Solenopsis clustered within theFirm5 clade. In contrast to the Firm3-Firm5 clades, most Hy-menoptera-associated sequences were scattered throughout thegenus and either clustered with or were closely related to lactoba-cilli known from vertebrate hosts or from diverse environmental

sources (Fig. 2; see also Fig. S2 in the supplemental material). Mostreads from the pyrosequencing surveys, however, tended to clus-ter into several operational taxonomic units (OTUs) per host(Table 2). The most abundant Lactobacillus OTUs associated withSolenopsis, for example, were closely related to L. sakei and L. plan-tarum, both of which are used in food fermentation (2). The mostabundant M. smithii-associated OTUs were closely related to sev-eral lactobacilli that are common inhabitants of the intestinaltracts of rodents, birds, and humans (Table 2). These M. smithii-associated OTUs were found in both fungus-garden and workersamples (see Table S2 in the supplemental material). As alreadyreported in McFrederick et al. (16), halictids associated mainlywith Lactobacillus OTUs that were related to flower-inhabiting,fructophilic lactobacilli (52) or to a clade that includes

FIG 1 16S rRNA gene maximum-likelihood phylogeny of the genus Lactobacillus, based on full or nearly full-length sequences only. Branch widths areproportional to bootstrap support from 100 pseudoreplicates. Highlighted branches represent Lactobacillus associates of honey or bumble bees. Major clades areindicated with curved lines and named according to previous studies (47–50).

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flower-inhabiting and fructophilic lactobacilli (53) and lactoba-cilli used in sourdough fermentation (54). Some of the halictid-associated OTUs formed monophyletic clades, but these cladesdid not exhibit the same level of divergence as the Firm3 andFirm4 clades (Fig. 2 and 4). Many of the terminal branches thatincluded Hymenoptera-associated sequences exhibited highbootstrap support (see Fig. S2 in the supplemental material).

Partial 16S rRNA gene phylogeny, including Hymenopteraassociates. The deeper branching patterns in the partial 16S phy-logeny did not agree with the full-length phylogeny. For example,

the partial 16S rRNA analysis recovered the L. salivarius clade as aparaphyletic series of branching lineages leading to the monophy-letic L. delbrueckii (acidophilus) clade (see Fig. S1 in the supple-mental material). The L. plantarum and L. buchneri clades werealso no longer monophyletic in the partial phylogeny but insteadwere both broken into two separate clades. The L. reuteri and L.casei clades remained monophyletic in the partial 16S analysis.Although the partial 16S analysis was unable to resolve deeperbranches in the Lactobacillus phylogeny, the membership of theterminal clades was stable across all analyses, and many of the

FIG 2 16S rRNA gene maximum-likelihood tree of the genus Lactobacillus, based on partial and complete sequences combined. Branch widths are proportionalto bootstrap support from 100 pseudoreplicates. Highlighted branches represent Hymenoptera associated lactobacilli as indicated in the figure legend. Cladescontaining lactobacilli associated with humans are indicated by a human figure, whereas clades containing lactobacilli used in food fermentation are indicatedby a piece of cheese. Major clades are indicated with curved lines and named according to previous studies (47–50).

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FIG 3 Secondary structure of the 16S rRNA molecule in the genus Lactobacillus. The degree of conservation in the molecule as determined by analysis of608 sequences is superimposed on the structure of the Lactobacillus acidophilus 16S molecule. Conservation of each nucleotide across the 608 analyzedLactobacillus species is indicated as follows: uppercase letters (�98% conservation), lowercase letters (90 to 98% conservation), closed circles (80 to 90%conservation), or open circles (�80% conservation). Canonical nucleotide pairs (G-C or A-U) are represented by dashes, wobble nucleotide pairs (G-U)are represented by small closed circles, A-G nucleotide pairs are represented by large open circles, and all other pairs are represented by large closed circles.

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terminal groups received high bootstrap support even in the par-tial 16S analysis (see Fig. S1 in the supplemental material).

DISCUSSIONHost specificity of Hymenoptera-associated lactobacilli. Hyme-noptera ranging from a solitary species (A. pura) to species thatlive in colonies numbering in the hundreds of thousands (Sole-nopsis) associate with lactobacilli that are either found in otherhosts or the environment. Social structure by itself does not deter-mine whether hymenopteran hosts associate with lactobacilli thatare host-specific or that are more recent acquisitions from theenvironment. Honey bees (colony sizes up to 60,000 [55]) andbumble bees (colony sizes from 50 to �400 [55]) are the onlyhymenopteran hosts examined to date that associate with lacto-bacilli that appear to be host specific and highly diverged fromother lactobacilli.

Previous studies already suggested that the corbiculate apidsassociate with host-specific lactobacilli (see, for example, refer-ences 14, 15, and 56), but it remains unclear why honey and bum-ble bees are special in this regard. The phylotypes associated withApis mellifera form a more consistent association with their hostscompared to Bombus, and this may be related to how A. melliferafounds new colonies (15, 56). Apis mellifera colonies are foundedvia swarming, where a colony divides and approximately half ofthe workers leave with the old queen to form a new colony,whereas most ants, social wasps, and bumble bees are nonswarm-ing (see reference 57 and references therein). The founding ofcolonies by thousands of individuals may allow for the between-generation maintenance of multiple strains that have been identi-fied within A. mellifera-associated phylotypes (56). Why Bombusspecies, in which nests are always founded by single queens (58),maintain associations with host-specific bacteria remains to bedetermined in detailed studies of dispersing Bombus queens, aswell as the changes in associated microbial communities duringcolony founding. Bombus terrestris, the bumble bee whose micro-biota has been best studied (11, 12, 59), shares nectar via honey-pots inside the colony (60). Bombus species do not engage in oral-oral food exchange (trophallaxis) (61), so shared food stores (e.g.,honeypots), social contact (e.g., grooming), feces, or the nest en-vironment may serve as important means for social transmissionof bumble bee microbiota. In contrast, trophallaxis between nest-mates or other contact within the hive is known to be importantfor the establishment of the microbiota of A. mellifera (17). Mega-lopta and Solenopsis also share food within a colony via trophallaxis(31, 62) but do not harbor host-specific microbes. Trophallaxis alone,therefore, does not automatically lead to the maintenance of host-specific microbes.

Our phylogenetic analyses and BLAST searches suggest likelymechanisms regarding how environmental lactobacilli are re-cruited into association with sweat bees and ants. As we previouslyreported, sweat bees associate with lactobacilli that are related tolactobacilli isolated from flowers, and may therefore obtain thesebacteria from flowers (16). Mycocepurus smithii belongs to thegroup of attine ants that do not collect leaves to sustain growth oftheir fungus gardens, but instead collect insect frass, flower parts,seeds, and fruit-flesh (63). Two of the dominant LactobacillusOTUs associated with M. smithii (L. johnsonii and L. crispatus)have been isolated from A. mellifera guts (64), indicating that theselactobacilli may occur in the guts and frass of other insects. Myco-cepurus smithii colonies may therefore recruit L. johnsonii, L.crispatus, and L. salivarius from insect frass that they collect tosustain their fungus gardens. These lactobacilli are found in bothM. smithii fungus gardens and workers, indicating that they canoccupy broad ecological niches. Alternatively, M. smithii may becollecting fecal material of vertebrates such as mice, birds, or pigs,all of which are hosts to the lactobacilli associated with M. smithii.

Solenopsis, on the other hand, is omnivorous (65) and may beobtaining lactobacilli from plant, insect, or vertebrate foodsources. The most abundant Lactobacillus in Solenopsis was mostclosely related to an undescribed Lactobacillus species from fer-mented tea. This OTU was found to associate with S. invicta and S.geminata in Argentina, North America, and Taiwan, indicatingthat it might play an important role in the biology of Solenopsis.Lactobacillus plantarum, whose comparatively large genome mayallow it to inhabit a variety of environments (66), was also foundto associate with S. invicta and S. geminata in Argentina, NorthAmerica, and Taiwan. Lactobacillus plantarum is found in dairy,meat, plants, and the human gastrointestinal tract and may berecruited by Solenopsis from any of these sources. It is currentlyunknown whether these associations derived from an acquisitionby a Solenopsis lineage ancestral to the invasive Solenopsis lineages

TABLE 1 Maximum patristic distances of the major clades in the mostlikely full-length 16S phylogenetic tree, out of a maximum patristicdistance of 1.51 across the entire tree

Clade Patristic distance

L. salivarius 0.5L. casei 0.44L. buchneri 0.54L. plantarum 0.34L. reuteri 0.55L. delbrueckii (acidophilus) 1.21

FIG 4 Histogram of patristic distances from the base of monophyletic cladesof Hymenoptera associates to their most recent common ancestor. The honeybee-associated Firm3 and Firm4 clades exhibited the greatest divergence, whilethe honey bee-associated Firm5 clade exhibited an amount of divergence sim-ilar to that of some other Hymenoptera associates.

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and were then vertically transmitted within these Solenopsis lin-eages or whether Lactobacillus is recruited continually from theenvironment by Solenopsis. Notably, we found several Firm5 se-quences, which are thought to be specific to honey and bumblebees (15), associated with Solenopsis. These sequences were notabundant, suggesting that they may be transient and perhapspicked up by Solenopsis when scavenging dead A. mellifera or Bom-bus workers.

The function of lactobacilli in hymenopteran hosts outside ofthe honey and bumble bees is still relatively unexplored, but theavailable evidence suggests that lactobacilli facilitate digestion ofsugars and inhibit the growth of other microbes through acidifi-cation, thereby benefiting their hosts. Although 16S rRNA phylo-type does not translate well into functional phenotypes (67), lac-tobacilli exhibit some general properties which may serve asexaptations for the symbiotic habit. For example, lactic acid bac-teria (LAB) digest a variety of sugars, with the main end productbeing lactic acid, although other acids and ethanol are also com-mon end products (49). By lowering the pH of their environment,LAB inhibit the growth of many other bacteria (68). LAB are also

known for the secretion of bacteriocins, which are compoundsthat inhibit the growth of other bacteria (68). For example, L. sakeiproduces several bacteriocins that inhibit pathogenic and spoilageorganisms (69). These general properties of lactobacilli mean thatthey are likely to be beneficial to hymenopteran hosts, and furtherresearch should determine the relative importance of acidificationversus bacteriocin-secretion in the biology of ant- and bee-asso-ciated Lactobacillus.

Utility of the 16S rRNA gene for Lactobacillus identificationand phylogeny. Although our analysis of 16S rRNA did not re-solve the deeper branches in the Lactobacillus phylogeny, 16SrRNA did place sequences into terminal clades with confidence.Clade membership in all of our analyses was generally well sup-ported and largely agrees with the clade structures suggested inprevious studies (47–50). By using alignments based on full-length sequences only, partial and complete sequences combined,and partial sequences only, we were able to assess the influence ofmissing data or 454 pyrosequencing length data on phylogeneticreconstructions. Although the analysis using only partial sequencesperformed poorly with regard to the placement of deeper branches,

TABLE 2 Ten most abundant Lactobacillus OTUs (clustered at �97% sequence identity) associated with three ant and three bee species (bee speciesare binned as halictids)a

Host Source of read No. of reads Closest phylogenetic relative Best BLAST hitSequenceidentity (%)

Solenopsis Brood geminata TX 5,993 Undescribed L. sakei 92Brood geminata TW 2,118 L. plantarum L. plantarum 99Brood invicta TX 935 L. curvatus L. curvatus 99Brood invicta TX 756 L. brevis L. brevis 99Pooled invicta TW 661 L. plantarum L. plantarum 99Pooled invicta TW 324 L. plantarum L. plantarum 99Pooled geminata TW 261 L. paracasei L. casei 99Brood geminata TW 167 L. kimchicus L. odoratitofui 99Brood geminata TW 156 Undescribed L. sakei 93Brood geminata TW 116 L. vaccinostercus L. vaccinostercus 99

Mycocepurus smithii Garden 14,152 L. johnsonii L. johnsonii 99Worker 3,748 L. crispatus L. crispatus 99Garden 2,794 L. salivarius L. salivarius 97Garden 1,059 L. aviarius L. aviarius 99Garden 806 L. crispatus L. crispatus 98Worker 598 L. salivarius L. salivarius 99Garden 586 L. reuteri L. reuteri 99Worker 431 L. salivarius L. salivarius 98Worker 420 L. aviarius/L. johnsonii L. aviarius 90Garden 408 L. johnsonii L. johnsonii 95

Halictids Larva 20,669 L. kunkeei/L. ozensis L. kunkeei 93Pollen 15,761 L. fructivorans L. fructivorans 91Larva 3,923 L. kunkeei/L. ozensis L. kunkeei 93Pollen 3,631 L. kunkeei/L. ozensis L. kunkeei 94Pollen 1,991 L. kunkeei/L. ozensis L. kunkeei 93Pollen 1,557 L. fructivorans L. fructivorans 90Larva 1,455 L. kunkeei/L. ozensis L. kunkeei 93Pollen 1,285 L. kunkeei/L. ozensis L. kunkeei 94Frass 1,102 L. paracasei L. casei 99Pollen 397 L. kunkeei/L. ozensis L. kunkeei 94

a The source of read indicates the types of samples from which the OTUs were isolated (TX, Texas; TW, Taiwan; pooled, workers and brood from five colonies). The number ofreads represents the number of reads that cluster into each OTU. The closest phylogenetic relative is the closest Lactobacillus species in our phylogenetic reconstruction with which aparticular read clustered (Fig. 2). The best BLAST hit is the top hit to a named Lactobacillus species from a BLAST search of NCBI’s entire nucleotide collection. The sequenceidentity is the percent sequence identity of the query to the best BLAST hit. Several OTUs shared top BLAST hits to the same Lactobacillus species but shared �97% sequenceidentity to each other.

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all of our analyses placed sequences into terminal clades with confi-dence.

Other studies have found that short pyrosequencing data canbe placed accurately into an existing full-length phylogeny (70),and our results suggest that if a highly variable region can be ac-curately aligned, alignments built on short pyrosequencing sizeddata can accurately place sequences into terminal clades. Our sec-ondary structural models of 16S rRNA indicate that the hairpinstem and loop in V1 is the most variable region in Lactobacillus.Next-generation sequencing surveys targeting V1 should providethe best taxonomic resolution for closely related lactobacilli.

Conclusions. We created highly accurate comparative modelsof 16S rRNA secondary structure and used these models to pre-cisely align the entire 16S rRNA gene, including fast-evolving re-gions. Maximum-likelihood phylogenetic reconstructions usingour structurally informed sequence alignments revealed that honeyand bumble bees associate with host-specific Lactobacillus. In con-trast, regardless of colony size or within-colony oral sharing offood (trophallaxis), sweat bees and ants associate with lactobacillithat are closely related to those found in vertebrate hosts or indiverse environments. Host specificity therefore appears to be theexception rather than the rule for Hymenoptera-associated lacto-bacilli. Nest founding by colony fission has been proposed as alikely means for long-term transmission of microbiota withinhoney bee lineages (15). M. smithii may facultatively found nestsby colony fissioning (34), and yet we found that M. smithii doesnot associate with host-specific lactobacilli. This suggests that (i)facultative colony fissioning is not sufficient to maintain long-term associations between a social-insect lineage and all host-spe-cific microbiota; (ii) regular colony founding by single queensmay disrupt long-term associations because new microbiota arefrequently acquired by a social-insect lineage during that stage;and (iii) obligate colony fissioning is more likely than facultativecolony fissioning to maintain long-term host-microbe specifici-ties in a social insect. Studies of lactobacilli associated with otherobligate colony-fissioning Hymenoptera such as meliponine beesand related solitary and communal nesters such as euglossine bees(55) will help determine whether colony-fissioning or some othercharacteristic of apid biology promotes host specificity. Regardlessof how they are acquired, lactobacilli are known to inhibit thegrowth of other microbes and may be beneficial whether they arecoevolved with their host or are recruited by the host from envi-ronmental sources through mechanisms of partner choice.

ACKNOWLEDGMENTS

This material is based on work supported by National Science Foundationgrant PRFB-1003133 awarded to Q.S.M. and grant DEB-0919519awarded to U.G.M., Texas Higher Education Coordinating Board grant01923 awarded to L. E. Gilbert, and National Institutes of Health grantGM067317 awarded to R.R.G.

We appreciate technical assistance from D. A. Estrada in the initialprocessing of the Solenopsis sequences. We thank three anonymous re-viewers for their helpful comments.

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Supplemental file S1. Supplemental text for 16S rRNA sequence alignment, secondary structure models, and Lactobacillus phylogenetics. 16S rRNA secondary structure models for 38 lactobacilli and 9 other Firmicutes. Canonical nucleotide pairs (G-C or A-U) are represented by dashes, wobble nucleotide pairs (G-U) are represented by small closed circles, A-G nucleotide pairs are represented by large open circles, and all other pairs are represented by large closed circles. The role of 16S rRNA secondary structure in Lactobacillus phylogenetics

Introduction

The 16S rRNA gene has so far failed to yield robust phylogenies for the genus Lactobacillus (1), despite an abundance of 16S rDNA sequence information (68,044 sequences, National Center for Biotechnology Information nucleotide database, accessed 14 June 2012). Previous 16S Lactobacillus phylogenies, however, did not utilize the higher order structure of the 16S RNA molecule to optimize the sequence alignment, an essential step to reconstruct the best phylogenetic tree (2, 3). Comparative structural models of the Lactobacillus 16S rRNAs will improve the quality of sequence alignments and improve phylogenetic reconstructions and the analysis of 16S-based next-generation sequencing surveys of bacterial communities. Of the nine hypervariable regions of the 16S gene, some windows (e.g.V3-V5, positions ~400- 860 Escherichia coli numbering) are not sufficient for classification of most human-associated Lactobacillaceae sequences to the genus level (4). Other 16S regions, such as V1-V2 (positions ~60- 220 E. coli numbering), may allow for better resolution (5). In addition, better alignments that explicitly juxtapose analogous secondary structure may also improve taxonomic assignment of next-generation 16S amplicon sequences. Due to the ubiquitous use of 16S rRNA information for bacterial identification and phylogenetic reconstruction, knowledge of 16S secondary structure and its utility in DNA sequence alignments is clearly needed. Methods Sequence Alignment and RNA Secondary Structure

Comparative analysis is used to identify an RNA secondary structure that is common to a set of sequences that are known to have the same function and higher-order structure. Starting in the early 1980's, covariation analysis, a specific type of comparative analysis, was applied to a sequence alignment to predict a Bacterial 16S rRNA secondary structure (6). Initially the simplier covariation methods only identified canonical base pairs (ie. G:C, A:U, and G:U) that occurred within a regular helix composed of at least two base pairs that are consecutive and anti-parallel with one another. However, more sophisticated covariation methods now identify all types of canonical and non-canonical base pairs with a set of nucleotides that covary with one another, regardless of their proximity to other structural elements (7, 8). In parallel with the contribution of more accurate and sensitive covariation methods, the original secondary structure models were refined as the number and phylogenetic and structural diversity of 16S rRNA sequences increased. A few of the originally proposed base pairs were removed when the variation at the two base paired positions were not coordinated (ie. variation but no covariation) in the larger dataset. In addition, new base pairs were

proposed for the larger dataset when two positions have similar patterns of variation (i.e. covariation) were identified. While the vast majority of these base pairs were canonical G:C, A:U, and G:U, a few were non-canonical, including the base pair exchanges - A:A <> G:G, A:G <> G:A, and U:U <> C:C. The vast majority of the base pairs are arranged adjacent and anti-parallel with one another to form nested helices, while a few helices formed pseudoknots and other base pairs were arranged in parallel (3).

In addition to the refinements in the comparative structure models, our confidence in the proposed comparative structure model were quantified and increased with the larger datasets that were analyzed with more sophisticated computational methods (9). With a sufficiently broad sampling of Bacterial 16S rRNAs, strong and robust patterns of sequence and secondary structure conservation and variation were discovered. Patterns of structural variation at specific regions of the 16S rRNA were identified and shown to be diagnostic of the organisms on specific branches of the phylogenetic tree (2, 9, 10) (www.rna.ccbb.utexas.edu/SAE/2B/ConsStruc/). While the accuracy of regions of the rRNA comparative structure models were substantiated with site directed mutagenesis, chemical modifications, and other experiments, the most authoritative assessment of the accuracy was determined from the high resolution crystal structures of the 30S and 50S ribosomal subunits (11, 12). Approximately 97% of the base pairs, including all of the non-canonical base pairs, psuedoknots, and other irregular structural elements in the comparative 16S rRNA secondary structure models are in the crystal structure (13). The strength of the covariation for each predicted base pair has been quantified and used as a confidence rating for each base pair (http://www.rna.ccbb.utexas.edu/SAE/2A/nt_Frequency/BP/). Given this very high accuracy, as gauged with the high-resolution crystal structures, we are most confident that all or nearly all of the base pairs in the comparative structure models for the rRNAs from different organisms are also correct, including all of the 16S rRNA secondary structure models for the Lactobacillus.

The accuracy of these predicted secondary structure models are directly associated with the quality of the sequence alignment. Better alignments facilitate better comparative structure models. And vice a versa, very accurate comparative structure models are the basis for the juxtaposition of nucleotides that are components of similar and analogous structural elements, especially in those highly variable regions that can have large variances in the number of nucleotides with little or no sequence identity. Thus these secondary structure-based alignments do not attempt to maximize sequence identity a priori. Instead they attempt to maximize the alignment of similar structural elements.

After the 16S rRNA sequences were semi-automatically aligned with the template-based alignment program - CRWAlign (14). We refined the alignment manually with the alignment editor ‘‘AE2’’ (developed by T. Macke, Scripps Research Institute, San Diego, CA; 15). This tool was developed for Sun Microsystems’ (Santa Clara, CA, USA) workstations running the Solaris operating system.

The manual alignment process utilizes the CRWAlign program to identify nucleotides in a column that might not map to the same locations in the secondary and tertiary structure. A visual inspection of the alignment determines if these flagged nucleotides should be realigned. If necessary, this is done manually with the AE2 alignment editor. For regions of the alignment with high sequence similarity and

minimal variance in the number of nucleotides, the information in the primary structure is sufficient to align sequences with confidence. In contrast, for more variable regions in closely related sequences or between more distantly related sequences, a high-quality alignment can only be produced when secondary and/or tertiary structure information is included. Secondary Structure Diagrams Secondary structure diagrams were generated after the first secondary structure model was derived with comparative methods. These diagrams were refined as the model was modified based on increased data and improved covariation methods (see above). While the Comparative RNA Web (CRW) Site (http://www.rna.ccbb.utexas.edu/) contains more than 200 16S rRNA secondary structure diagrams that sample the diversity within the Bacteria, 47 secondary structure diagrams for each of the major phylogenetic groups of Lactobacillus and a few related organisms were generated for this study. The secondary structure diagrams were generated with the interactive secondary structure program - XRNA (written in the C programming language for Sun Microsystems’ workstations running the Solaris operating system by B. Weiser and H. Noller, University of California, Santa Cruz). All structure diagrams are available at: http://www.rna.ccbb.utexas.edu/. Discussion: Utility of 16S rDNA for Lactobacillus identification and phylogeny Our secondary structural models of 16S rRNA indicate that the hairpin stem and loop in V1 is the most variable region in Lactobacillus. Accordingly, 16S primers targeting this region for next-generation sequencing surveys of Lactobacillus should provide the best taxonomic resolution for closely related taxa. Other regions that exhibit variation are bases 180-200, 440-480, 997-1043, and 1242-1294 (E. coli numbering), although these regions will not provide the same resolution as V1-V2. The structural models that we present here will also serve as valuable resources for aligning Lactobacillus 16S rRNA.

Our 16S rRNA phylogenetic tree had high support values for terminal branching patterns but not deeper branching patterns in the Lactobacillus phylogeny. Even with our highly accurate and structurally informed sequence alignment, the 16S rRNA gene did not confidently resolve the deeper branches in the Lactobacillus phylogeny. The Lactobacillus phylogeny has so far been reconstructed using both 16S rDNA sequence information (1, 16-18) or with phylogenomic data, using information from many genes (1, 16). The phylogenomic approach, while resolving deeper branches with confidence, results in trees with few taxa. Multilocus sequence typing schemes have been developed for several lactobacilli and their relatives (19-24), and sequences from these studies may be useful in designing primers for single copy protein coding genes conserved across the genus Lactobacillus, thereby providing greater phylogenetic resolution and coverage of the genus.

While our analysis of 16S rRNA did not resolve the deeper branches in the Lactobacillus phylogeny, 16S rRNA does place sequences into terminal clades with confidence. Clade membership in all of our analyses was generally well supported, and largely agrees with the clade structures suggested in previous studies (16-18). By using

alignments based on full-length sequences only, partial and complete sequences combined, and partial sequences only, we were able to assess the influence of missing data or 454 pyrosequencing length data on phylogenetic reconstructions. Although the full-length and partial and complete analyses differed in the placement of some deeper branches, the inclusion of partial sequences had little effect on the overall results. The placement of the partial and complete sequences into their respective clades was almost completely congruent with the phylogeny based on full-length sequences. The analysis using only partial sequences performed poorly with regard to the placement of deeper branches, but placed sequences robustly into terminal clades remarkably well. Other studies have found that short pyrosequencing data can be placed accurately into an existing full-length phylogeny (25), and our results suggest that if a highly variable region (i.e., the V1 region for Lactobacillus) can be accurately aligned, alignments built on short pyrosequencing sized data can accurately place sequences into terminal clades. Implications for Lactobacillus systematics

By gathering all publicly available 16S sequences and clustering sequences that shared 97% or greater sequence identity, we created an updated, complete representation of the diversity of the genus Lactobacillus. In agreement with previous studies (17), we determined that the L. delbrueckii (acidophilus) clade represents a significant portion of Lactobacillus diversity. Also in agreement with previous studies (1, 26), we determined that Paralactobacillus and Pediococcus are within Lactobacillus, and that the overall taxonomy of the genus Lactobacillus needs significant revisionary work. References: 1. Claesson, M. J., D. van Sinderen, and P. W. O'Toole. 2008. Lactobacillus

phylogenomics-towards a reclassification of the genus. International Journal of Systematic and Evolutionary Microbiology 58:2945-2954.

2. Woese, C. R. 1987. Bacterial evolution. Microbiological Reviews 51:221. 3. Gutell, R. R., N. Larsen, and C. R. Woese. 1994. Lessons from an evolving

rRNA: 16S and 23S rRNA structures from a comparative perspective. Microbiological Reviews 58:10-26.

4. Jumpstart Consortium Human Microbiome Project Data Generation Working Group. 2012. Evaluation of 16S rDNA-Based Community Profiling for Human Microbiome Research. PLoS ONE 7:e39315.

5. Kullen, M. J., R. B. Sanozky-Dawes, D. C. Crowell, and T. R. Klaenhammer. 2000. Use of the DNA sequence of variable regions of the 16S rRNA gene for rapid and accurate identification of bacteria in the Lactobacillus acidophilus complex. Journal of Applied Microbiology 89:511-516.

6. Woese, C. R., L. J. Magrum, R. Gupta, R. B. Siegel, D. A. Stahl, J. Kop, N. Crawford, R. Brosius, R. Gutell, J. J. Hogan, and H. F. Noller. 1980. Secondary structure model for bacterial 16S ribosomal RNA: phylogenetic, enzymatic and chemical evidence. Nucleic Acids Research 8:2275-2294.

7. Gutell, R., A. Power, G. Hertz, E. Putz, and G. Stormo. 1992. Identifying constraints on the higher-order structure of RNA: continued development and application of comparative sequence analysis methods. Nucleic Acids Research 20:5785-5795.

8. Shang, L., W. Xu, S. Ozer, and R. R. Gutell. 2012. Structural constraints identified with covariation analysis in ribosomal RNA. PLoS ONE 7:e39383.

9. Cannone, J., S. Subramanian, M. Schnare, J. Collett, L. D'Souza, Y. Du, B. Feng, N. Lin, L. Madabusi, K. Mueller, N. Pande, Z. Shang, N. Yu, and R. R. Gutell. 2002. The comparative RNA web (CRW) site: an online database of comparative sequence and structure information for ribosomal, intron, and other RNAs. BMC Bioinformatics 3:2.

10. Gutell, R. R. 1992. Presented at the The Symposium--The Origin and Evolution of Prokaryotic and Eukaryotic Cells, Shimoda, Japan.

11. Wimberly, B. T., D. E. Brodersen, W. M. Clemons, R. J. Morgan-Warren, A. P. Carter, C. Vonrhein, T. Hartschk, and V. Ramakrishnan. 2000. Structure of the 30S ribosomal subunit. Nature 407:327-339.

12. Ban, N., P. Nissen, J. Hansen, P. B. Moore, and T. A. Steitz. 2000. The complete atomic structure of the large ribosomal subunit at 2.4 a resolution. Science 289:905-920.

13. Gutell, R. R., J. C. Lee, and J. J. Cannone. 2002. The accuracy of ribosomal RNA comparative structure models. Current Opinion in Structural Biology 12:301-310.

14. Gardner, D. P., W. Xu, D. P. Miranker, S. Ozer, J. J. Cannone, and R. R. Gutell. In Press. Presented at the IEEE International Conference on Bioinformatics and Biomedicine (BIBM 2012), Philadelphia, USA.

15. Larsen, N., G. J. Olsen, B. L. Maidak, M. J. McCaughey, R. Overbeek, T. J. Macke, T. L. Marsh, and C. R. Woese. 1993. The ribosomal database project. Nucleic Acids Research 21:3021-3023.

16. Canchaya, C., M. J. Claesson, G. F. Fitzgerald, D. Van Sinderen, and P. W. O'Toole. 2006. Diversity of the genus Lactobacillus revealed by comparative genomics of five species. Microbiology 152:3185-3196.

17. Felis, G. E., and F. Dellaglio. 2007. Taxonomy of Lactobacilli and Bifidobacteria. Current Issues in Intestinal Microbiology 8:44-61.

18. Pot, B., and E. Tsakalidou. 2009. Taxonomy and metabolism of Lactobacillus, p. 3-58. In A. Ljungh and T. Wadstrom (ed.), Lactobacillus Molecular Biology: from Genomics to Probiotics. Caister Academic Press, Norfolk, UK.

19. Ruiz-Garbajosa, P., M. J. M. Bonten, D. A. Ronbinson, J. Top, S. R. Nallapareddy, C. Torres, T. M. Coque, R. Canton, F. Baquero, B. E. Murray, R. del Campo, and R. J. L. Willems. 2006. Multilocus sequence typing scheme for Enterococcus faecalis reveals hospital-adapted genetic complexes in a background of high rates of recombination. Journal of Clinical Microbiology 44:2220-2228.

20. Berger, B., D. P. Pridmore, C. Barretto, F. Delmas-Julien, K. Schreiber, F. Arigoni, and H. Brussow. 2007. Similarity and differences in the Lactobacillus acidophilus group identified by polyphasic analysis and comparative genomics. Journal of Bacteriology 189:1311-1321.

21. Cai, H., B. T. Rodriguez, W. Zhang, J. R. Broadbent, and J. L. Steele. 2007. Genotypic and phenotypic characterization of Lactobacillus casei strains isolated from different ecological niches suggests frequent recombination and niche specificity. Microbiology 153:2655-2665.

22. Raftis, E. J., E. Salvetti, S. Torriani, G. E. Felis, and P. W. O'Toole. 2011. Genomic diversity of Lactobacillus salivarius. Applied and Environmental Microbiology 77:954-965.

23. Picozzi, C., G. Bonacina, I. Vigentini, and R. Foschino. 2010. Genetic diversity in Italian Lactobacillus sanfranciscensis strains assessed by multilocus sequence typing and pulsed-field gel electrophoresis analyses. Microbiology 156:2035-2045.

24. Buhnik-Rosenblau, K., V. Matsko-Efimov, M. Jung, H. Shin, Y. Danin-Poleg, and Y. Kashi. 2012. Indication for co-evolution of Lactobacillus johnsonii with its host. BMC Microbiology 12:149.

25. Liu, Z., C. Lozupone, M. Hamady, F. D. Bushman, and R. Knight. 2007. Short pyrosequencing reads suffice for accurate microbial community analysis. Nucleic Acids Research 35:e120.

26. Haakensen, M., V. Pittet, and B. Ziola. 2011. Reclassification of Paralactobacillus selangorensis Leisner et al. 2000 as Lactobacillus selangorensis comb. nov. International Journal of Systematic and Evolutionary Microbiology 61:2979-2983.

 

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5ʼ

3ʼ

Lactobacillus acidophilus (GenBank accession number M58802)

1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.LactobacillusJune 2012

NNAAAACGAG A G U U

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Canonical nucleotide pairs (G-C or A-U) are represented by dashes, wobble nucleotide pairs (G-U) are represented by small closed circles, A-G nucleotide pairs are represented by large open circles, and all other pairs are represented by large closed circles.

Taxonomy:

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’Lactobacillus delbrueckii subsp.

bulgaricus 2038 (CP000156)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus 8.Lactobacillus delbrueckii 9.Lactobacillus delbrueckii subsp. bulgaricus July 2012

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Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus amylovorus GRL 1112 (CP002338)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus 8.Lactobacillus amylovorus July 2012

UUUAAAAUGAG A G U U

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UA A C C G A G G A A C U G C A U C G G A

AAC U G U U U U U C

UU

GAGUGCAGAA

GA

GGAGAGU

GGAACUCCAUGUGUA

GCGGUGG

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUCUCU

GGUCUGCAACU

GAC

GCU

G

AGGCUC G

AA

A GCAUGGG

UA G

CGAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUGC C G U

AAAC

GAU

G A G U G C U A AG

UG

UU

GG

GA

GGU U U

CC

GCC

UC

UC

AG

UG

CU G

CAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

UA

GU

GCAAUCUGUAGAG

A U A C G G A G U UCCCU

U CGGGGA

CG

CU

A AG

AC A

GG

U GGUGC

A UG

GCUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U G U U A U U A G

U U GC C

A GC A U U

AA

GUUGGGCACU

CUAAUGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAGUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

GC

AG

UAC

A A C GA

GAA G

CA

A GCC

UG C

GA

AG

GC

AAG

CG

AAU

CU

CU

GAAAG

CU

GU

UCUCA

GU

UCGGACUGCAGUC

UGC

AACUCGACUGCAC

GAAGC

UG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCACG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGG

GAGUCUGCAAUGCC

CAAA

GCCGGU

GGCCUA

A CCU

U CGGG

AAGGA

GCCGUCUAA

GGCAGGGCAGAUGA

CUGGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A G G AGA

ACCUGCGGCUGGAUCACCUCCUUUCUAAGGAAG

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus gasseri ATCC 33323 (AF519171)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus 8.Lactobacillus gasseri July 2012

AAAAUGAG A G U U

U GAUCCUGGCUCAG

GA

CGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U C G AG

CG

AG

CU

UG C

CU

AG

AU

GA

AU

UU

GG

UG

CU

UGC

AC

CA

GA

UG

AA

AC

UA

GAUAC

AA

GC

GA

GCGGC

GG

ACGGG

UG

AGU

AACA

CGUGGGU A

ACC

UG

CCCAAGAG

A C U G GG

A U AA C A C C U G G

AA

ACAGAUGCU

AAUA

CCGGAUA

AC

AACACUAGACG

CAUGUCUAGAGUU

UA

AAAGAUGGUU

CU G C U A U C A

CUCUUGG

AU

GG

ACCUGCGGU

GCA

UU

AG

CUA

GUU

GG

UA

AGG

UAACG

G CU

UA

CC

AA

GG

CAAU G A

UG

CA

UA

GCCGAGUUG

AG A

GA C UG A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

CA

A G U C U G A U G G A GCAA C

GC

CG

CGUGAGUG

AAGAA

GGGUUUC

G G C U CGU A A A

G C U CU

GU

UG

GU

AG

UGAAGAAA

GAU

AG

AG

GU

AGUA

A C UG

GC

CU

UU

A U UUGAC G G

UAA

UU

AC

UU

AG

AA

AGUCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGUG

C

AGGCGGUUCAAU

AAGUCUGAUGUG

AAA

GCCUUCGGCU

CA A C C G G A G A A U U G C A U C A G A

AAC U G U U G A A C

UU

GAGUGCAGAA

GA

GGAGAGU

GGAACUCCAUGUGUA

GCGGUGG

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUCUCU

GGUCUGCAACU

GAC

GCU

G

AGGCUC G

AA

A GCAUGGG

UA G

CGAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUGC C G U

AAAC

GAU

G A G U G C U A AG

UG

UU

GG

GA

GGU U U

CC

GCC

UC

UC

AG

UG

CU G

CAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

CA

GU

GCAAACCUAAGAG

A U U A G G U G U UCCCU

U CGGGGA

CG

CU

G AG

AC A

GG

U GGUGC

A UG

GCUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U G U C A U U A G

U U GC C

A UC A U U

AA

GUUGGGCACU

CUAAUGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAGUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

AC

GG

UAC

A A C GA

GAA G

CG

A A CC

UG C

GA

AG

GC

AAG

CG

GAU

CU

CU

GAAAG

CC

GU

UCUCA

GU

UCGGACUGUAGGC

UGC

AACUCGCCUACAC

GAAGC

UG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCACG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUCUGUAACACC

CAAA

GCCGGU

GGGAUA

A CCUU

U AUAGG

AGUCA

GCCGUCUAA

GGUAGGACAGAUGA

UUAGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A G G AGA

ACCUGCGGCUGGAUCACCUCCUUU

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus delbrueckii subsp. lactis(M58823)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus 8.Lactobacillus delbrueckii June 2012

NNCAAAUUGAG A G U U

U GAUCCUGGCUCAG

GA

CGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

GC GA GC U GA A U U C A A A GA U U C C UU

CGGGAGGAUUUGUUGGANNNNAGCGGC

GG

AUGGG

UG

AGU

AACA

CGUGGGC A

AUC

UG

CCCUAAAG

A C U G GG

A U AC C A C U U G G

AA

ACAGGUGCU

AAUA

CCGGAUA

AC

AACAUGAAUCG

CAUGAUUCAAGUU

UG

AAAGGCGGCG

CA

A G C U G U C ACUUUAGG

AU

GA

GCCCGCGGC

GCA

UU

AG

CUA

GUU

GG

UG

GGG

UAAAG

G CC

UA

CC

AA

GG

CAAU G A

UG

CG

UA

GCCGAGUUG

AG A

GA C UG A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

CA

A G U C U G A U G G A GCAA C

GC

CG

CGUGAGUG

AAGAA

GGUCUUC

G G A U CGU A A A

G C U CU

GU

UG

UU

GG

UGAAGAAG

GAU

AG

AG

GC

AGUA

A C UG

GU

CU

UU

A U UUGAC R G

UAA

UC

AA

CC

AG

AA

AGUCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGCG

C

AGGCGGAAUGAU

AAGUCUGAUGUG

AAA

GCCCACGGCU

CA A C C G U G G A A C U G C A U C G G A

AAC U G U C A U U C

UU

GAGUGCAGAA

GA

GGAGAGU

GGAACUCCAUGUGUA

GCGGUGG

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUCUCU

GGUCUGCAACU

GAC

GCU

G

AGGCUC G

AA

A GCAUGGG

UA G

CGAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUGC C G U

AAAC

GAU

G A G C G C U A GG

UG

UU

GG

GG

ACU U U

CC

GGU

CC

UC

AG

UG

CC G

CAG

C AA

ACG

CAUUA

AGCGCUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C N G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

CU

GC

GCUACACCUAGAG

A U A G G C C G U UCCCU

U CGGGGA

CG

CA

G AG

AC A

GG

U GGUGC

A UG

GCUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U G U C U U U A G

U U GC C

A UC A U U

AA

GUUGGGCACU

CUAGAGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAGUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

GC

AG

UAC

A A C GU

GAA G

CG

A A CC

CG C

GA

GG

GU

AAG

CG

GAU

CU

CU

UAAAG

CU

GC

UCUCA

GU

UCGGACUGCAGGC

UGC

AACUCGCCUGCAC

GAAGC

UG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCACG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGG

AAGUCUGCAAUGCC

CAAA

GUCGGU

GGGAUA

A CCUU

U AUAGG

AGUCA

GCCGCCUAA

GGCAGGGCAGAUGA

CUGGGGNNN

NNN

NGU

AAC

A AG

N

N N N N N N N N N N NGA

ACCUGNNNNNNGAUCACCUCCUUUCUA

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus sp. 61D (FR681902)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus July 2012

ACCUACGUAG A G U U

U GAUCAUGGCUCAG

GA

CGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U C G AG

CG

AG

CU

UG C

CU

AG

AU

GA

UU

UC

GG

UG

CU

UGC

AC

CG

AA

UG

AA

AC

UA

GAU

AC

AA

GC

GA

GCGGC

GG

ACGGG

UG

AGU

AACA

CGUGGGU A

ACC

UG

CCCAAGAG

A C U G GG

A U AA C A C C U G G

AA

ACAGAUGCU

AAUA

CCGGAUA

AC

AACAUCUAGCG

CAUGCUAGAAGUU

UG

AAAGAUGGG

UU

U C U A U C ACUCUUGG

AU

GG

ACCUGCGGU

GCA

UU

AG

CUA

GUU

GG

UA

AGG

UAACG

G CU

UA

CC

AA

GG

CAAU G A

UG

CA

UA

GCCGAGUUG

AG A

GA C UG A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

CA

A G U C U G A U G G A GCAA C

GC

CG

CGUGAGUG

AAGAA

GGGUUUC

G G C U CGU A A A

G C U CU

GU

UG

GU

GG

UGAAGAAA

GAU

AG

AG

GU

AGUA

A C UG

GC

CU

UU

A U UUGAC G G

UAA

UC

AC

CU

AG

AA

AGUCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGUG

C

AGGCGGUUCAAU

AAGUCUGAUGUG

AAA

GCCUUCGGCU

CA A C C G G A G A A U U G C A U C A G A

AAC U G U U G A A C

UU

GAGUGCAGAA

GA

GGAGAGU

GGAACUCCAUGUGUA

GCGGUGG

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUCUCU

GGUCUGCAACU

GAC

GCU

G

AGGCUC G

AA

A GCAUGGG

UA G

CGAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUGC C G U

AAAC

GAU

G A G U G C U A AG

UG

UU

GG

GA

GGU U U

CC

GCC

UC

UC

AG

UG

CU G

CAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

CA

GU

GCAAACCUAAGAG

A U U A G G U G U UCCCU

U CGGGGA

CG

CU

G AG

AC A

GG

U GGUGC

A UG

GCUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U G U C A U U A G

U U GC C

A UC A U U

AA

GUUGGGCACU

CUAAUGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAGUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

AC

GG

UAC

A A C GA

GAA G

CG

A A CC

UG C

GA

AG

GC

AAG

CG

GAU

CU

CU

GAAAG

CC

GU

UCUCA

GU

UCGGACUGUAGGC

UGC

AACUCGCCUACAC

GAAGC

UG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCACG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUCUGUAACACC

CAAA

GCCGGU

GAGAUA

A CC

AU

U AAA

GG

AGUCA

GCCGUCUAA

GGUAGGACAGAUGA

UUAGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A G G AGA

ACCUGCGGUUGGAUCACCUCCUUA

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

uncultured bacterium (DQ922980)1.cellular organisms 2.Bacteria 3.environmental samples July 2012

UUUAAUCGAG A G U U

U GAUCCUGGCUCAG

GA

CGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U C G AA

CG

CA

CU

C UU

GU

UU

AG

AU

UG

AA

GG

AGC

UUG

CU

CC

UC

AU

UG

AU

AA

AC

AUU

UG

AG

UG

AG

UGGC

GG

ACGGG

UG

AGU

AACA

CGUGGGU A

ACC

UG

CCCUAAAG

UG G G GG

A U AA C A U U U G G

AA

AAAGAUGCU

AAUA

CCGCAUA

AA

ACCUAACAUCG

CAUGGUGUAGGGU

UG

AAAGAUGGUU

UC

G G C U A U C ACUUUAGG

AU

GG

ACCCGCGGU

GCA

UU

AG

UUA

GUU

GG

UG

AGG

UAAAG

G CU

CA

CC

AA

GA

CCGU G A

UG

CA

UA

GCCGACCUG

AG A

GGGUA A

UC GGC C

AC

ACUGGGA

CUGA

GA

C A C GG C C C A G

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

GA

A G U C U G A U G G A GCAA C

GC

CG

CGUGAGUG

AAGAA

GGUUUUC

G G A U CGU A A A

A C U CU

GU

UG

UU

GG

AGAAGAAU

GUA

UC

UG

AU

AGUA

A C UG

AU

CA

GG

UA GUGAC G G

UAU

CC

AA

CC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGCG

C

AGGCGGUUUCUU

AAGUCUGAUGUG

AAA

GCCUUCGGCU

CA A C C G A A G A A G U G C A U C G G A

AAC U G G G A A A C

UU

GAGUGCAGAA

GA

GGACAGU

GGAACUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUGUCU

GGUCUGUAACU

GAC

GCU

G

AGGCUC G

AA

A GCAUGGG

UA G

CAAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUGC C G U

AAAC

GAU

G A G U G C U A GG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CC G

CAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

CU

UU

GACCACUCUAGAG

A U A G A G C U U UCCCU

U CGGGGA

CA

AA

G UG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U A U U A C U A G

U U GC C

A GC A U U

UA

GUUGGGCACU

CUAGUGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGG

CGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

AU

GG

UAC

A A C GA

GUU G

CG

A GAC

CG C

GA

GG

UU

UAG

CU

AAU

CU

CU

UAAAA

CC

AU

UCUCA

GU

UCGGAUUGUAGGC

UGC

AACUCGCCUACAU

GAAGC

CG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCAUG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CAAA

GCCGGU

GAGGUA

A CCCU

U CGGGG

AGCCA

GCCGUCUAA

GGUGGGACAGAUGA

UUAGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A G G AGA

ACCUGCGGCUGGAUCACCUCCUUUCUA

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus salivarius(AB186340)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus June 2012

NNN N N N N

N NNNNNNNNNNNNN

NN

NNN

NN

AC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

A C G A A A C U U U

CUUAC

ACC

GAAUGC

UUGCUUU

CACC

GUAAG

AAGUUGAGUGGC

GG

ACGGG

UG

AGU

AACA

CUUGGGU A

ACC

UG

CCUAAAAG

A A G G GG A U A

A C A C U U G GAA

ACAGGUGCU

AAUA

CCGUAUA

UC

UCUAAGGAUCG

CAUGAUCCUUAUA

UG

AAAGAUGGUU

CU G C U A U C G

CUUUUAG

AU

GG

ACCCGCGGC

GUA

UU

AA

CUA

GUU

GG

UG

GGG

UAACG

G CC

UA

CC

AA

GG

UGAU G A

UA

CG

UA

GCCGAACUG

AG A

GGU UG A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

CA

A G U C U G A U G G A GCAA C

GC

CG

CGUGAGUG

AAGAA

GGUCUUC

G G A U CGU A A A

A C U CU

GU

UG

UU

AG

AGAAGAAC

ACG

AG

UG

AG

AGUA

A C UG

UU

CA

UU

CG A UGAC G G

UAU

CU

AA

CC

AG

CA

AGUCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGG

GAACG

C

AGGCGGUCUUUU

AAGUCUGAUGUG

AAA

GCCUUCGGCU

UA A C C G G A G U A G U G C A U U G G A

AAC U G G A A G A C

UU

GAGUGCAGAA

GA

GGAGAGU

GGAACUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

AGCGGCUCUCU

GGUCUGUAACU

GAC

GCU

G

AGGUUC G

AA

A GCGUGGG

UA G

CAAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCACGC C G U

AAAC

GAU

G A A U G C U A GG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CC G

CAG

C UA

ACG

CAAUA

AGCAUUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

CU

UU

GACCACCUAAGAG

A U U A G G C U U UCCCU

U CGGGGA

CA

AA

G UG

AC A

GG

U GGUGC

A UG

GCUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U G U U G U C A G

U U GC C

A GC A U U

AA

GUUGGGCACU

CUGGCGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

CGA

CGUC

AAGUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

AC

GG

UAC

A A C GA

GUC G

CG

A GAC

CG C

GA

GG

UU

UAG

CU

AAU

CU

CU

UAAAG

CC

GU

UCUCA

GU

UCGGAUUGUAGGC

UGC

AACUCGCCUACAU

GAAGU

CG

GAAUCGC

UAGUAAUCGCGAA U

CA

GCAUG

UC

GC

GG

UGA

AU

ACGU

UAC

CCGGGCCUUGU

ACA

CUCCGCCCG

UC

ACACCAAGA

GAGUUUGUAACACC

CAAA

CCCGGU

GGGGUA

A CCG

C AAGA

AACCA

CCGUCUAA

GGUGGGACAGAUGA

UUGGGG

GAAG

UCG

AAC

A AG

G

A G C C GA

G A C N NNN

NNNNNNNNNNNNNNNNNNNNNNNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus apodemi (AJ871178)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus June 2012

NNN N N N N

N NNNCCUGGCUCAG

GA

UGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

A C G A A G C U U C

UUUAU

CAC

CGAGUGC

UUGCACUC

ACCG

AUAAA

GAGCUUAGUGGC

GA

ACGGG

UG

AGU

AACA

CGUGGGC A

ACC

UG

CCCAAAAG

A G G G GG

A U AA C A C U U G G

AA

ACAGGUGCU

AAUA

CCGCAUA

AC

CACAGUUACCG

CAUGGUAACUGUG

UG

AAAGGUGGCU

AU G C U A C C G

CUUUUGG

AU

GG

GCCCGCGGC

GCA

UU

AG

CUA

GUU

GG

UG

AGG

UAAAG

G CU

UA

CC

AA

GG

CAAU G A

UG

CG

UA

GCCGAACUG

AG A

GGU UG A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGGCG

AA

A G C C U G A U G G A GCAA C

GC

CG

CGUGGGUG

AAGAA

GGUCUUC

G G A U CGU A A A

A C C CU

GU

UG

UU

AG

AGAAGAAA

GUG

CG

UG

AG

AGUA

A C UG

UU

CA

CG

UU UCGAC G G

UAU

CU

AA

CC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UA

UC

CG

GAUUU

AU

U G GGC

GUAA

AGG

GAACG

C

AGGCGGUCUUUU

AAGUCUGAUGUG

AAA

GCCUUCGGCU

UA A C C G G A G U A G U G C A U U G G A

AAC U G G G A G A C

UU

GAGUGCAGAA

GA

GGAGAGU

GGAACUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

AGCGGCUCUCU

GGUCUGUAACU

GAC

GCU

G

AGGUUC G

AA

A GCGUGGG

UA G

CAAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCACGC C G U

AAAC

GAU

G A A U G C U A AG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CU G

CAG

C UA

ACG

CAAUA

AGCAUUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

UU

CU

GACAAUCCUAGAG

A U A G G A C U U CUCCU

U CGGGAG

CA

GA

A UG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U G U U G U U A G

U U GC C

A GC A U U

AA

GUUGGGCACU

CUAGCAA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

AC

GG

UAC

A A C GA

GUC G

CG

A GAC

CG C

GA

GG

UU

UAG

CA

AAU

CU

CU

UAAAG

CC

GU

UCUCA

GU

UCGGAUUGUAGGC

UGC

AACUCGCCUACAU

GAAGU

CG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCAUG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CAAA

GCCGGU

GGGGUA

A CCU

U UUGG

AGCCA

GCCGUCUAA

GGUGGGACAGAUGA

UUGGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A G G AGA

ACCUGCGGGNNNNNNNNNNNNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus capillatus (AB365978)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus June 2012

NAG A G U U

U GAUCCUGGCUCAG

GA

CGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG U

A C G C A A A U C U U U CA

C C GA A U G C

UU

GCAUUCAUC

GAAAGAUUUGAGUGGC

GA

ACGGG

UG

AGU

AACA

CGUGGGU A

ACC

UG

CCCAGAAG

A A G G GG

A U AA C A C U U G G

AA

ACAGGUGCU

AAUA

CCGUAUA

AC

AACAAAAACCG

CCUGGUUUUUGUU

UA

AAAGAUGGUU

CU G C U A U C A

CUUCUGG

AU

GG

ACCCGCGGC

GUA

UU

AG

CUA

GUU

GG

UG

AGG

UAAUG

G CU

CA

CC

AA

GG

CAAU G A

UA

CG

UA

GCCGAACUG

AG A

GGU UG A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

AA

A G U C U G A U G G A GCAA C

GC

CG

CGUGAGUG

AAGAA

GGUUUUC

G G A U CGU A A A

A C U CU

GU

UG

UU

AG

AGAAGAAC

GUG

UG

UG

AG

AGUA

A C UG

UU

CA

UG

CA GUGAC G G

UAU

CU

AA

CC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGG

GAACG

C

AGGCGGUUUUUU

AAGUCUGAUGUG

AAA

GCCUUCGGCU

UA A C C G A A G U C G U G C A U U G G A

AAC U G G A A G A C

UU

GAGUGCAGAA

GA

GGAGAGU

GGAACUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

AGCGGCUCUCU

GGUCUGUAACU

GAC

GCU

G

AGGUUC G

AA

A GCAUGGG

UA G

CAAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUGC C G U

AAAC

GAU

G A A U G C U A AG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CU G

CAG

U UA

ACG

CAUUA

AGCAUUC

CGCCU

G G GG

A G U ACG A U C G

CA

AGAUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

UU

CU

GCCAAUCUAAGAGA A U U A G A G U

UCCCU

U CGGGGA

CA

GA

A UG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U A U U A C U A G

U U GC C

A GC A U U

AA

GUUGGGCACU

CUAGUGA

G

A

CUGCCGGUG

ACAAACCGGAAGG

AAGGUGGGGA

UGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

AC

AG

UAC

A A C GA

GUC G

CA

A GAC

CG C

GA

GG

UC

AAG

CU

AAU

CU

CU

UAAAA

CU

GU

UCUCA

GU

UCGGAUUGUAGGC

UGC

AACUCGCCUACAU

GAAGU

CG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCAUG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CAAA

GCCGGU

GAGGUA

A CCU

U UUGG

AGCCA

GCCGUCUAA

GGUGGGACAGAUGA

UUGGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A G G AGA

ACCUGCGGCUGGNNNNNNNNNNNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus hayakitensis (AB267406)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus June 2012

NNN N N N N

N NNNNNNNNNNNNN

GA

UGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

A C G C A A C U U U C U U A CA C C

G A U G CUU

GCAUCACC

GUAAGAAAGUUGAGUGGC

GG

ACGGG

UG

AGU

AACA

CGUGGGU A

ACC

UG

CCCAGAAG

A G G G GG

A U AA C A C U U G G

AA

ACAGGUGCU

AAUA

CCGCAUA

UC

UCUAAGAACCG

CAUGGUUCUUAGA

UG

AAAGAUGGUU

CU G C U A U C G

CUUCUGG

AU

GG

ACCCGCGGC

GCA

UU

AA

CUA

GUU

GG

UG

GGG

UAACG

G CC

UA

CC

AA

GG

UGAU G A

UG

CG

UA

GCCGAACUG

AG A

GGU UG A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGGCG

AA

A G C C U G A U G G A GCAA C

GC

CG

CGUGAGUG

AAGAA

GGUCUUC

G G A U CGU A A A

G C U CU

GU

UG

UU

AG

AGAAGAAC

ACU

GA

UG

AG

AGUA

A C UG

UU

CA

UC

A G UUGAC G G

UAU

CU

AA

CC

AG

CA

AGUCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UA

UC

CG

GAUUU

AU

U G GGC

GUAA

AGG

GAACG

C

AGGCGGUUUUUU

AAGUCUGAUGUG

AAA

GCCUUCGGCU

UA A C C G G A G A A U A G C A U U G G A

AAC U G G A A G A C

UU

GAGUGCAGAA

GA

GGAGAGU

GGAACUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

AGCGGCUCUCU

GGUCUGUAACU

GAC

GCU

G

AGGUUC G

AA

A GCGUGGG

UA G

CAAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCACGC C G U

AAAC

GAU

G A A U G C U A GG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CC G

CAG

C UA

ACG

CAAUA

AGCAUUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

CU

UU

GACCACUUGAGAG

A U C A A G C U U UCCCU

U CGGGGA

CA

AA

G UG

AC A

GG

U GGUGC

A UG

GCUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U G U U G U C A G

U U GC C

A GC A U U

AA

GUUGGGCACU

CUGGCGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

CGA

CGUC

AAGUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

AU

GA

UAC

A A C GA

GUC G

CG

A GAC

CG C

GA

GG

UU

UAG

CU

AAU

CU

CU

UAAAG

UC

AU

UCUCA

GU

UCGGAUUGUAGGC

UGC

AACUCGCCUACAU

GAAGU

CG

GAAUCGC

UAGUAAUCGCGAA U

CA

GCAUG

UC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CAAA

GCCGGU

GGGGUA

A CCUU

UUAGG

AGCUA

GCCGUCUAA

GGUGGGACAGAUGA

UUGGGGUGN

NNN

NN N

NNN

N NN

N

N N N N N N N N N N NNN

NNNNNNNNNNNNNNNNNNNNNNNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus saerimneri (AY255802)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus June 2012

NAG A G U U G

A

UCCUGGCUCAGG

AUGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

G C G C A U C G G C

CCAACUGAUUGAAGAUGC

UUGCAUCCGAUUGACGAUGGUU

UACCGAUGAGCGGC

GG

ACGGG

UG

AGU

AACA

CGUAGGU A

ACC

UG

CCCAGAAG

CG G G GG

A U AA C A C C U G G

AA

ACAGAUGCU

AAUA

CCGCAUA

GG

UCAUUUGACCG

CAUGGUCAAAUGA

UU

AAAGAUGGCU

CU G C U A U C A

CUUCUGG

AU

GG

ACCUGCGGC

GUA

UU

AG

CUA

GUU

GG

UA

AGG

UAACG

G CU

UA

CC

AA

GG

CGAU G A

UA

CG

UA

GCCGAGUUG

AG A

GA C UG A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A G

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

CA

A G U C U G A U G G A GCAA C

GC

CG

CGUGAGCG

AAGAA

GGUCUUC

G G A U CGU A A A

A C U CU

GU

UG

UU

AG

AGAAGAAC

ACG

GG

UG

AG

AGUA

A C UG

UU

CA

CC

UG UUGAC G G

UAU

CU

AA

CC

AG

CA

AGUCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UA

UC

CG

GAUUU

AU

U G GGC

GUAA

AGG

GAACG

C

AGGCGGUUCUUU

AAGUCUGAUGUG

AAA

GCCUUCGGCU

UA A C C G A A G A U G U G C A U U G G A

AAC U G G G G A A C

UU

GAGUGCAGAA

GA

GGAGAGU

GGAACUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

AGCGGCUCUCU

GGUCUGUAACU

GAC

GCU

G

AGGUUC G

AA

A GCGUGGG

UA G

CGAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCACGC C G U

AAAC

GAU

G A A U G C U A GG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CC G

CAG

C UA

ACG

CACUA

AGCAUUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCUAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

UU

UU

GACCACCUAAGAG

A U U A G G U U U UCCCU

U CGGGGA

CA

AA

A UG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U G U U G U C A G

U U GC C

A GC A U U

CA

GUUGGGCACU

CUGGCGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

GC

AG

UAC

A A C GA

GUC G

CG

A A AC

CG C

GA

GG

UU

UAG

CA

AAU

CU

CU

UAAAG

CU

GC

UCUCA

GU

UCGGACUGUAGGC

UGC

AACUCGCCUR

CAC

GAAGU

CG

GAAUCGC

UAGUAAUCGCGAA U

CA

GCAUG

UC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CAAA

GCCGGU

GGGGUA

A CCU

U UUGG

AGCCA

GCCGUCUAA

GGUGGGACAGAUGA

UUGGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A G G AGA

ACCUGCGGCUGGAUCACCUCCUUUCU

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus sp. C33LV5 (AF197125)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus July 2012

UAG A G U U

U GAUCCUGGCUCAG

GA

CGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

A C GA A GC U U U U A A U C A A U A A A U G C

UUGCAUUUAGCGAUUAAAAGA

CUGAGUGGC

GA

ACGGG

UG

AGU

AACA

CGUAGGC A

ACC

UG

CCCAAAAG

A G G G GG

A U AA C A C U U G G

AA

ACAGGUGCU

AAUA

CCGCAUA

AC

CAUGAAAACCG

CAUGGUUUUUAUG

UA

AAAGAUGGUU

UC

G G C U A U C ACUUUUGG

AU

GG

GCCUGCGGC

GUA

UU

AG

CUU

GUU

GG

UG

GGG

UAAUG

G CC

UA

CC

AA

GG

CAAU G A

UA

CG

UA

GCCGAACUG

AG A

GGU UG A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

AA

A G U C U G A U G G A GCAA C

GC

CG

CGUGAAUG

AAGAA

GGCCUUC

G G G U CGU A A A

A U U CU

GU

UG

UU

AG

AGAAGAAU

GUG

CG

UG

AG

AGUA

A C UG

UU

CA

UG

UA UUGAC G G

UAU

CU

AA

CC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGG

GAACG

C

AGGCGGUCUUUU

AAGUCUGAUGUG

AAA

GCCUUCGGCU

UA A C C G G A G U A G U G C A U U G G A

AAC U G G A A G A C

UU

GAGUGCAGAA

GA

GGAGAGU

GGAACUCCAUGUGUA

GCGGUGG

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

AGCGGCUCUCU

GGUCUGUAACU

GAC

GCU

G

AGGUUC G

AA

A GCGUGGG

UA G

CAAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCACGC C G U

AAAC

GAU

G A A U A C U A AG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CU G

CAG

C UA

ACG

CAUUA

AGUAUUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

UU

CU

GACAAUCCUAGAG

A U A G G A C U U UCCCU

U CGGGGA

CA

GA

A UG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U A U U G U C A

AG

U U GC C

A GC A U U

CA

GUUGGGCACU

CUGGCGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

AC

GG

UAC

A A C GA

GUC G

CA

A A CU

CG C

GA

GG

GC

AAG

CU

AAU

CU

CU

UAAAG

CC

GU

UCUCA

GU

UCGGACUGCAGGC

UUG

CAACUCGCCUGCAC

GAAGU

CG

GAAUCGC

UAGUAAUCGCGAA U

CA

GCAUG

UC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CAAA

GCCGGU

GGGGUA

A CCU

U UUGG

AGCCA

GCCGUCUAA

GGUGGGACAGAUGA

UUGGGGUGA

AGU

CGU

AAC

A AG

G

U A GC

C C G U A G G AGA

ACCUGCGGCUGGAUCANNNNNNNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

uncultured bacterium (GU293196)1.cellular organisms 2.Bacteria 3.environmental samples July 2012

NAG A G U U

U GAUCCUGGCUCAG

GA

CGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

A C GA GA A GA U U C A U GA A C A A GU GCU

UGCAUUUGUUCGUGAUGAUUCGAGUGGC

GG

ACGGG

UG

AGU

AACA

CGUGGGU A

ACC

UG

CCCAGAAG

UA G G GG

A U AC C A C U U G G

AA

ACAAGUGCU

AAUA

CCGUAUA

AC

CACAAUGACCG

CAUGGUCAUUGUG

UG

AAAGGUGGUU

CU G C U A C C G

CUUCUGG

AU

GG

ACCCGCGGC

GUA

UU

AA

CUA

GUU

GG

UA

GGG

UAACG

G CC

UA

CC

AA

GG

UGAU G A

UA

CG

UA

GCCGAACUG

AG A

GGU UG A

UC GGC C

AC

AAUGGGA

CUGA

GA

A C GG C C C A U

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

GA

A G U C U G A U G G A GCAA C

GC

CG

CGUGAAUG

AAGAA

GGUCUUC

G G A U CGU A A A

G U U CU

GU

UG

UU

AG

AGAAGAAU

ACC

CA

UA

AU

AGUA

A C UG

AU

UA

UG

GG A UGAC G G

UAU

CU

AA

CC

AG

CA

AGUCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGG

GAACG

C

AGGCGGUCUUAU

AAGUCUGAUGUG

AAA

GCCUUCGGCU

UA A C C G G A G A A U A G C A U U G G A

AAC U G U A A G A C

UU

GAGUGCAGAA

GA

GGAGAGU

GGAACUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

AGCGGCUCUCU

GGUCUGUAACU

GAC

GCU

G

AGGUUC G

AA

A GCGUGGG

UA G

CGAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCACGC C G U

AAAC

GAU

G A A U G C U A GG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CU G

CAG

C UA

ACG

CAAUA

AGCAUUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

UU

CU

GCUAACCCAAGAG

A U U G G G C U UCCCU

U CGGGGA

CA

GA

A UG

AC A

GG

U GGUGU

A UG

GCUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U G U U G U C A G

U U GC C

A UC A U U

UA

GUUGGGCACU

CUGACGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAGUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

GCACGUGCUAC A A U

GG

AC

GA

UAC

A A C GA

GUC G

CA

A A AC

CG C

GA

GG

UC

AAG

CU

AAU

CU

CU

UAAAA

UC

GU

UCUCA

GU

UCGGAUUGCAGGC

UGC

AACUCGCCUGCAU

GAAGU

CG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCAUG

CC

AC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CAAA

GCCGGU

GAGGUA

A CCUU

U UUUGG

AGCUA

GCCGUCUAA

GGUGGGACAGAUGA

UUGGGGUGA

AGU

CGU

AAC

A AG

G

U AA

A C N N N N N N NNN

NNNNNNNNNNNNNNNNNNNNNNNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus backi (DQ406862)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus July 2012

NNN N N N N

N NNNNNNNNNNNNN

NN

NGA

AC

GC

U

GGCCG

GC

GU

G

CC

UAAU

ACAUGC

A

A

G U CG A

A C GC A C A GA U A U C A A C A GA A GC U GCU

UGCAGUGGAAGUUAAUUGAUGUGAGUGGC

GG

ACGGG

UG

AGU

AACA

CGUGGGU A

ACC

UA

CCCAAAAG

UG G G GG

A U AA C A U U U G G

AA

ACAGAUGCU

AAUA

CCGCAUA

AU

UUAAGUGACCA

CAUGGUCACUUAA

UG

AAAGAUGGUU

UC

G G C U A U C ACUUUUGG

AU

GG

ACCCGCGGC

GUA

UU

AG

CUA

GUU

GG

UG

GGA

UAACG

G CC

UA

CC

AA

GG

CGAU G A

UA

CG

UA

GCCGACCUG

AG A

GGGUA A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

UA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

AA

A G U C U G A U G G AG CAA C

GC

CG

CGUGAGUG

AAGAA

GGUUUUC

G G A U CGU A A A

A C U CU

GU

UG

UU

GG

AGAAGAAC

AGG

GA

CU

AG

AGUA

A C UG

UU

AG

UC

CU A UGAC G G

UAU

CC

AA

CC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGCG

C

AGGCGGUUUUUU

AAGUCUGAUGUG

AA

CUUCGGCUUA A C C G A A G A A G U G C A U U A G A

AAC U G G G A A A C

UU

GAGUGCAGAA

GA

GGAGAGU

GGAACUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUCUCU

GGUCUGUAACU

GAC

GCU

G

AGGCUC G

AA

A GUAUGGG

GA G

CGAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUAC C G U

AAAC

GAU

G A A U G C U A AG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CU G

CAG

C UA

ACG

CAUUA

AGCAUUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

ACUAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

CU

UU

GACCACUGUAGAG

A U A C A G C U UU

CU

U CGGGGA

CA

AA

G UG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U A U G A C U A G

U U GC C

A GC A U U

AA

GUUGGGCACU

CUAGUGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAAUC

AGC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

UU

GG

UAC

A A C GA

GUU G

CG

A A CC

CG C

GA

GG

GU

AAG

CU

AAU

CU

CU

UAAAG

CC

AA

UCUCA

GU

UCGGAUUGUAGGC

UGC

AACUCGCCUACAU

GAAGU

CG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCACG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CGAA

GCCGGU

GGGGUA

A CCUCU

AUGAGG

AGCUA

ACCGUCUAA

GGUGGGACAGAUGA

UUGGGGGUGN

NNN

NN N

NNN

N NN

N

N N N N N N N N N N NNN

NNNNNNNNNNNNNNNNNNNNNNNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus halophilus (AB240455)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus July 2012

NNN N G U U

U GAUCCUGGCUCAG

GA

CGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U C G CA

CG

CA

CA

AC

CG

UU

AA

C CU

GA

UC

CU

GCU

UGC

AG

GU

GA

CG

UU

AA

UG

GA

CG

UG

AG

UGGC

GG

ACGGG

UG

AGU

AACA

CGUGGGU A

ACC

AA

CCCUGAAG

CG G G GG

A U AA C C U U U G G

AA

ACAGAGGCU

AAUA

CCGCAUAG

UU

UAUCGCGACCU

CCUGGUCGCAAUA

AU

AAAGACGGCU

UC

G G C U G U C ACUUCAGG

AC

AG

ACCCGCGGC

GUA

UU

AG

CUA

GUU

GG

UG

GGA

UAAAG

G CC

UA

CC

AA

GG

CGAU G A

UA

CG

UA

GCCGACCUG

AG A

GGGUA A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

CA

A G U C U G A U G G A GCAA C

GC

CG

CGUGAGUG

AAGAA

GGGUUUC

G G C U CGU A A A

A C G CU

GU

UG

UU

GG

AGAAGAAC

CGG

GG

GU

AG

AGUA

A C UG

UU

AU

CC

CC UUGAC G G

UAU

CC

AA

CC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGCG

C

AGGCGGUUUUUU

AAGUCUGAUGUG

AAA

GCCUUCGGCU

UA A C C G A A G A A G G G C A U C A G A

AAC U G A G A A G C

UU

GAGGACAGAA

AA

GGAAAGU

GGAACUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUUUCU

GGUCUGUUACU

GAC

GCU

G

AGGCUC G

AA

A GUAUGGG

GA G

CGAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUAC C G U

AAAC

GAU

G A A U G C U A AG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CU G

CAG

C UA

ACG

CAUUA

AGCAUUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

CU

UU

GACCGCUGUCGAG

A G A C A G U U U GCCCU

U CGGGGC

CA

AA

G UG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U A U G A C U A G

U U GC C

A GC A U U

UA

GUUGGGCACU

CUAGUGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAAUC

AGC

A

UGCCCC U

GA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

UC

GG

GAC

A A C GA

GUA G

CG

C GCC

CG C

GA

GG

GU

UAG

CU

AAU

CU

CU

AAAAA

CC

GA

UCUCA

GU

UCGGAUUGCAGGC

UGC

AACUCGCCUGCAU

GAAGC

CG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCAUG

CC

GC

GG

UGA

AU

CCGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CAAA

GCCGGU

GGGGCA

A CCCU

U CGGGG

AGCUA

GCCGUCUAA

GGUGGGACAGAUGA

UUGGGGUGA

AGU

CGU

AAC

A AG

G

U A A N N N N N N N NNN

NNNNNNNNNNNNNNNNNNNNNNNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Paralactobacillus selangorensis (NR_024885)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Paralactobacillus July 2012

NNN N N N N

N NNNNNNNNCUCAG

GA

CGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

A C G A A C U U U C A U C G A G U G CUU

GCACUUGAUGAAAGUGAGUGGC

GG

ACGGG

UG

AGU

AACA

CGUGGGU A

ACC

UG

CCCA

AAG

CG G G GA

A U AA C A U U U G G

AA

ACAGAUGCU

AAUA

CCGCAUA

AC

AACGAAGACCA

CAUGGUCUUCGUU

UG

AAAGACGGCG

UA

A G C U G U C ACUUUGGG

AU

GG

ACCCGCGCC

GUA

UU

AG

CUA

GUU

GG

UA

AGG

UAACG

G CC

UA

CC

AA

GG

CGAU G A

UA

CG

UA

GCCGACCUG

AG A

GGGUA A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

UA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

AA

A G U C U G A U G G A GCAA C

GC

CG

CGUGAGUG

AAGAA

GGUUUUC

G G A U CGU A A A

A C U CU

GU

UG

UU

AG

AGAAGAAC

GUG

GG

UG

AG

AGUA

A C UG

CU

CA

UC

CA GUGAC G G

UAU

CU

AA

CC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGCG

C

AGGCGGUCUUUU

AAGUCUGAUGUG

AAA

GCCCUCGGCU

UA A C C G A G G A A G U G C A U C G G A

AAC U G G A A G A C

UU

GAAUGCAGAA

GA

GGAGAGU

GGAACUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUCUCU

GGUCUGUGAUU

GAC

GCU

G

AGGCUC G

AA

A GCGUGGG

UA G

CAAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCACGC C G U

AAAC

GAU

G A A U A C U A AG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CU G

CAG

C UA

ACG

CAUUA

AGUAUUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

CGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

UU

CU

GCUAUCUCUAGAA

A U A G A G A G U UCCCU

U CGGGGA

CA

GA

A UG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U A U U A C U A G

U U GC C

A GC A U U

AA

GUUGGGCACU

CUAGUGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

AU

GG

UAC

A A C GA

GUC G

CU

A A AC

CG C

GA

GA

GU

CAA

CU

AAU

CU

CU

UAAAA

CC

AU

UCUCA

GU

UCGGAUUGCAGGC

UGC

AACUCGCCUGCAU

GAAGU

CG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCACG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CGAA

GUCGGU

GGGGCA

A CCCG

U ANNNN

NGCUA

GCCGCCUAA

GGUGGGACCGAUGA

UUAGGGUGA

AGU

CGU

AAC

A AG

G

N N N N N N N N N N NNN

NNNNNNNNNNNNNNNNNNNNNNNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus concavus (AY683322)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus July 2012

NNN N N N N

N NNNNNNNNNNNNN

GA

CGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

AC

GA

GU

UU

CA

UU

UU

AA

GG

AU

CA

AG

GU

GCU

UGC

AC

CG

AG

AG

AA

UU

AA

AA

AG

AA

AC

GA

GUGGC

GG

ACGGG

UG

AGU

AACA

CGUGGGU A

ACC

UA

CCCUAAAG

UG G G GG

A U AA C A U U U G G

AA

ACAGAUGCU

AAUA

CCGCAUA

AC

GAACGAAACCA

CAUGGUUUCGUUC

UG

AAAGAUGGCG

UA

A G C U A U C ACUUUUGG

AU

GG

ACCCGCGGC

GUA

UU

AG

CUA

GUU

GG

UG

AGG

UAACG

G CU

CA

CC

AA

GG

CGAU G A

UA

CG

UA

GCCGACCUG

AG A

GGGUG A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

AA

A G U C U G A U G G A GCAA C

GC

CG

CGUGAGUG

AAGAA

GGUUUUC

G G A U CGU A A A

A C U CU

GU

UA

UC

GG

AGAAGAAC

GUA

UC

UG

GU

AGUA

A C UG

GC

CA

GG

UA GUGAC G G

UAU

CC

GA

UC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGUG

C

AGGCGGUUUUUU

AAGUCUGAUGUG

AAA

GCCUUCGGCU

UA A C C G A A G A A A U G C A U U G G A

AAC U G G G G A A C

UU

GAGUGCAGAA

GA

GGAGAGU

GGAACUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUCUCU

GGUCUGUAACU

GAC

GCU

G

AGGCUC G

AA

A GCGUGGG

UA G

CAAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCACGC C G U

AAAC

GAU

G A G U G C U A AG

UG

UU

GG

GG

GGU U U

CC

GCC

CC

UC

AG

UG

CU G

CAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G C C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AG

AC C U U

ACCAGGUCU

UGA

CA

UC

UA

GC

GCCAAUCCUAGAG

A U A G G A C G U UCCCU

U CGGGGA

CG

CU

A AG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U A U G A U U A G

U U GC C

A GC A U U

AA

GUUGGGCACU

CUAGUCA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGCGGGGA

UGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

CU

AG

UAC

A A C GA

GUU G

CG

A GAC

CG C

GA

GG

UC

AAG

CU

AAU

CU

CU

AAAAG

CU

AG

UCUCA

GU

UCGGAUUGUAGGC

UGC

AACUCGCCUACAU

GAAGU

UG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCACG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CAAA

GCCGGU

GAGGUA

A CCCG

U AAGGG

AGCUA

GCCGUCUAA

GGUGGGACAGAUGA

UUAGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A G G AGA

ACCUGCNNNNNNNNNNNNNNNNNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus floricola (AB523781)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus July 2012

NAG A G U U

U GAUCC

CUGGCUCAGG

ACGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

A C G A G U U U G C

UCUUAUGAAGGUAGUGC

UUGCACUACUUGAUUAAGAA

UC

CAAACGAGUGGC

GG

ACGGG

UG

AGU

AACA

CGUGGGU A

ACC

UA

CCCUAAAG

CG G G GG

A U AA C A U U U G G

AA

ACAGAUGCU

AAUA

CCGCAUA

AC

AAUAAGAAUCG

AAUGUUUCUUAUU

UA

AAAGAUGGUU

UC

G G C U A U C ACUUUAGG

AU

GG

ACCUGCGGC

GUA

UU

AG

CUA

GUU

GG

UA

AGG

UAAUG

G CU

UA

CC

AA

GG

CGAU G A

UA

CG

UA

GCCGACCUG

AG A

GGGUG A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

AA

A G U C U G A U G G A GCAA C

GC

CG

CGUGAGUG

AUGAA

GGGUUUC

G G C U CGU A A A

A C U CU

GU

UG

UU

AG

AGAAGAAA

GAU

AG

UA

AG

AGUA

A C UG

UU

UA

UU

A U UUGAC G G

UAA

CU

AA

CC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGCG

C

AGGCGGCUAAUU

AAGUCUGAUGUG

AAA

GCCUUCGGCU

UA A C C G G A G A A G U G C A U U A G A

AAC U G A U U A G C

UU

GAGUGCAGAA

GA

GGAGAGU

GGAACUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGACUCUCU

GGUCUGUAACU

GAC

GCU

G

AGGCUC G

AA

A GCGUGGG

UA G

CAAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCACGC C G U

AAAC

GAU

G A G U G C U A AG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CU G

CAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

UGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

UU

UU

GACCACCUAAGAG

A U U A G G U U U UCCCU

U CGGGGA

CA

AA

A UG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U A U U A C U A G

U U GC C

A GC A U U

AA

GUUGGGCACU

CUAGUGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

AU

GG

UAC

A A C GA

GCA G

CG

A U AC

CG C

GA

GG

UU

UAG

CU

AAU

CU

CC

UAAAA

CC

AU

CCUCA

GU

UCGGAUUGCAGGC

UGC

AACUCGCCUGCAU

GAAGC

UG

GAAUCGC

UAGUAAUCGCAGA U

CA

GCAUG

CU

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CGAA

GCCGGU

GAGGUA

A CCUU

UUAGG

AGCCA

ACCGUCUAA

GGUGGGACAGAUGA

UUAGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A G G AGA

ACCUGCGGCUGGAUUCACCUCCUUN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus paracasei(AY773954)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus 8.Lactobacillus casei group June 2012

NNN N N N N

N NNNNNNNNNNNNN

NN

NNN

NN

NN

N

NNN

NN

NN

NG

CA

CACU

AUA

GUGC

A

G U CG A

A C G A G U U C UC

GUUGAUGAUCGGUGC

UUGCACCGAGAUUCAACA

UGGAACGAGUGGC

GG

ACGGG

UG

AGU

AACA

CGUGGGU A

ACC

UG

CCCUUAUG

UG G G GG

A U AA C A U U U G G

AA

ACAGAUGCU

AAUA

CCGCAUA

GA

UCCAAGAACCG

CAGGGUUCUUGGC

UG

AAAGAUGGCG

UA

U G C U A U C GCUUUUGG

AU

GG

ACCCGCGGC

GUA

UU

AC

CUA

GUU

GG

UG

AGG

UAAUG

G CU

CA

CC

AA

GG

CGAU G A

UA

CG

UA

GCCGAACUG

AG A

GGU UG A

UC GGC C

AC

AUUGGGA

CUGA

UA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG G G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

CA

A G U C U G A U G G A GCAA C

GC

CA

CGUGAGUG

AAGAA

GGCUUUC

G G G U CGU A GA

A C U CU

GU

UG

UU

GG

AAAAGAAU

GGU

CG

GC

AG

AGUA

A C UG

UU

GU

CG

GC GUGAC G G

UAU

CC

AA

CC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UA

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGCG

C

AGGCGGUUUUUU

AAGUCUGAUGUG

AAA

GCCUUCGGCU

UA A C C G G A G A A G U G C A U C G G A

AAC U G G A U A A C

UU

GAGUGCAGAA

GA

GGGUAGU

GGAACUCCAUGUGUA

GCGGUGG

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUACCU

GGUCUGCAACU

GAC

GCU

G

AGA CUC G

AA

A GCAUGGG

UA G

CGAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUGC C G U

AAAC

GAU

G A G U G C U A GG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CC G

GAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG C G C C C G

CA C A A GCA CA

GGAGCAUGUGGUU

UAAU

UG

GA

CACAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

UU

UC

GAUCACGAGAGAC

A U C A G G U A U CCCCC

C CGGGGG

CA

AA

A AA

AC A

GU

A AAGGC

A AG

GUUGUGA

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C C U A U G A C U A G

U U GC C

A GC A C A

UA

GUUGGGCACU

CUAGUAA

A

G

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACCCGCUAC A A U

GG

AC

GG

CAC

A A C GA

GUU G

CG

A GAC

CG C

GA

GG

UC

AAG

CU

AAU

CU

CU

UAAAG

CC

AU

UCUCA

CU

UCGGACUGUAGGC

GGC

AACUCGCCCACAC

GAAGU

UG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCACG

CC

GC

GG

AGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CGAA

GCCGGU

GGCGUA

A CCCUU UU

AGGG

AGCGA

GCCGUUUAA

GGUGGGACAAAUGA

GUAG

GUGA

AGU

C

UAG

AU G

A

G

C N N N N N N N N N NNN

NNNNNNNNNNNNNNNNNNNNNNNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus pantheris(AB362679)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.LactobacillusJuly 2012

UAG A G U U

U GAUCAUGGCUCAG

GA

UGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

GC

GA

AC

UU

AA

CU

AA

AU

GA

AU

GC

GG

UG

CU

UGC

AC

CA

AG

UG

AU

UU

UA

GA

GC

GG

UG

AG

CGGC

GG

AUGGG

UG

AGU

AACA

CGUGGGU A

ACC

UG

CCUCUAAG

CA G G GG

A U AA C A U U U G G

AA

ACAGAUGCU

AAUA

CCGUAUA

AA

UCCUAAAACCA

CAUGGUUUUAGGC

UG

AAAGGCGGCU

UC

G G C U G U C ACUUAGAG

AU

GG

ACCCGCGGC

GUA

UU

AG

CUA

GUU

GG

UG

AGG

UAAUG

G CU

CA

CC

AA

GG

CAAU G A

UA

CG

UA

GCCGAACUG

AG A

GGU UG A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

CA

A G U C U G A U G G A GCAA C

GC

CG

CGUGAGUG

AAGAA

GGCUUUC

G G G U CGU A A A

A C U CU

GU

UG

UU

GA

AGAAGAAC

ACG

UU

UG

AG

AGUA

A C UG

UU

CA

GA

CG UUGAC G G

UAU

UC

AA

CC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UA

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGCG

C

AGGCGGUUUUUU

AAGUCUGAUGUG

AAA

GCCCUCGGCU

UA A C C G A G G A A G U G C A U C G G A

AAC U G G G A A A C

UU

GAAUGCUGAA

GA

GGACAGU

GGAACUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUGUCU

GGUCAGUUAUU

GAC

GCU

G

AGGCUC G

AA

A GCAUGGG

UA G

CGAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUGC C G U

AAAC

GAU

G A A U A C U A GG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CC G

CAG

C UA

ACG

CAUUA

AGUAUUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

UU

CU

GCUAUUUCUAGAG

A U A G A A A G U UCCCU

U CGGGGA

CG

GA

A UG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U A U G A C U A G

U U GC C

A GC A U U

AA

GUUGGGCACU

CUAGUAA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

CGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

UU

GG

UAC

A A C GA

GUU G

CG

A A CU

CG C

GA

GG

GU

AAG

CU

AAU

CU

CU

UAAAG

CC

AA

UCUCA

GU

UCGGACUGUAGGC

UGC

AACUCGCCUACAC

GAAGU

CG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCAUG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CAAA

GCCGGU

GGGGCA

A CCCU

U CGGGG

AGCUA

GCCGUCUAA

GGUGGGACAGAUGA

UUAGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A G G AGA

ACCUGCGGUUGGAUCACCUCCUUA

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus kunkeei(AB559820)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus June 2012

NNN N N N N

U GAUCAUGGCUCAG

GA

CGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

A C G A G C U C U C

CCAAAUUGAUUUUAUGC

UUGCAUAAAUGAUUUUUGGAUU

CGGAGCGAGUGGC

GA

ACUGG

UG

AGU

AACA

CGUGGGU A

ACC

UG

CCCCGAAG

CG G G GG

A U AA C A U U U G G

AA

ACAAGUGCU

AAUA

CCGCAUAA

UU

AGUUGGAACCG

CAUGGUUCCAACU

UG

AAAGAUGGCU

CU G C U A U C A

CUUUGGG

AU

GG

ACCCGCGCC

GUA

UU

AG

UUA

GUU

GG

UG

AGA

UAAAA

G CC

CA

CC

AA

GA

CGAU G A

UA

CG

UA

GCCGACCUG

AG A

GGGUA A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A G

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

AA

A G U C U G A U G G A GCAA C

GC

CG

CGUGAGUG

AUGAA

GGUUUUC

G G A U CGU A A A

A C U CU

GU

UG

UU

AA

AGAAGAAC

AAG

UG

UU

AG

AGUA

A C UG

UU

AA

CA

CU UUGAC G G

UAU

UU

AA

CC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGCG

C

AGGCGGUUUUGU

AAGUCUGCUGUG

AAA

GCCCUCAGCU

CA A C U G A G G A A G U G C A G U G G A

AAC U A C A A A A C

UU

GAGUACAGAA

GA

GGAAAGU

GGAACUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUUUCU

GGUCUGUUACU

GAC

GCU

G

AGGCUC G

AA

A GCAUGGG

UA G

CGAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUGC C G U

AAAC

GAU

G A A U A C U A GG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CC G

CAG

C UA

ACG

CAUUA

AGUAUUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GUGGU

GGAGCAUGUGGUU

UAAU

UC

GA

UGCUAC G C

GA

AGAA

C C U UA

CCAGCUCU

UGA

CA

UC

UU

CU

GCCAACCCAAGAG

A U U G G G C G U UCCCU

U CGGGGA

CA

GA

A UG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U R U U A U U A G

U U GC C

A GC A U U

UA

GUUGGGCACU

CUAGUGA

G

A

CUGCCGGUG

AUAAACCGGAGG

AAGGUGGGGA

CGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGAGCUGGGCU

AC

ACACGUGCUAC A A U

GG

AU

GG

UAC

A A C GA

GUC G

CG

A A AC

CG C

GA

GG

UC

AAG

CU

AAU

CU

CU

UAAAG

CC

AU

UCUCA

GU

UCGGAUUGCAGGC

UGC

AACUCGCCUGCAU

GAAGU

UG

GAAUCAC

UAGUAAUCGUGGA U

CA

GCAUG

CC

AC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CAAA

GACGAU

GGGGUA

A CCUU

UUAGG

AGCUA

GUCGUCUAA

GGUGGGACAGAUGA

UUAGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A G G AGA

ACCUGCGGUUGGAUCACNNNNNNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus brevis ATCC 367 (CP000416)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus 8.Lactobacillus brevis July 2012

UGAG A G U U

U GAUCCUGGCUCAG

GA

CGA

AC

GC

U

GGC

GG

CA

UG

CC

UAAU

ACAUGC

A

A

G U CG A

A C G A G C U U C C

GUUGAAUGACGUGC

UUGCACUGAUUUCAACAA

UGAAGCGAGUGGC

GA

ACUGG

UG

AGU

AACA

CGUGGGGA

AUC

UG

CCCAGAAG

CA G G GG

A U AA C A C U U G G

AA

ACAGGUGCU

AAUA

CCGUAUA

AC

AACAAAAUCCG

CAUGGAUUUUGUU

UG

AAAGGUGGCU

UC

G G C U A U C ACUUCUGG

AU

GA

UCCCGCGGC

GUA

UU

AG

UUA

GUU

GG

UG

AGG

UAAAG

G CC

CA

CC

AA

GA

CGAU G A

UA

CG

UA

GCCGACCUG

AG A

GGGUA A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

AA

A G U C U G A U G G A GCAA U

GC

CG

CGUGAGUG

AAGAA

GGGUUUC

G G C U CGU A A A

A C U CU

GU

UG

UU

AA

AGAAGAAC

ACC

UU

UG

AG

AGUA

A C UG

UU

CA

AG

GG UUGAC G G

UAU

UU

AA

CC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGCG

C

AGGCGGUUUUUU

AAGUCUGAUGUG

AAA

GCCUUCGGCU

UA A C C G G A G A A G U G C A U C G G A

AAC U G G G A G A C

UU

GAGUGCAGAA

GA

GGACAGU

GGAACUCCAUGUGUA

GCGGUGG

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUGUCU

AGUCUGUAACU

GAC

GCU

G

AGGCUC G

AA

A GCAUGGG

UA G

CGAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUGC C G U

AAAC

GAU

G A G U G C U A AG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CU G

CAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCUAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

UU

CU

GCCAAUCUUAGAG

A U A A G A C G U UCCCU

U CGGGGA

CA

GA

A UG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U A U U A U C A G

U U GC C

A GC A U U

CA

GUUGGGCACU

CUGGUGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

AC

GG

UAC

A A C GA

GUU G

CG

A A GU

CG U

GA

GG

CU

AAG

CU

AAU

CU

CU

UAAAG

CC

GU

UCUCA

GU

UCGGAUUGUAGGC

UGC

AACUCGCCUACAU

GAAGU

UG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCAUG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CAAA

GCCGGU

GAGAUA

A CCU

U CGGG

AGUCA

GCCGUCUAA

GGUGGGACAGAUGA

UUAGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A G G AGA

ACCUGCGGCUGGAUCACCUCCUUUCU

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus fructivorans (X76330)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus July 2012

NAG A G U U

U GAUNNUGGCUCAG

GA

CGA

AC

GC

U

GGC

GG

CA

UG

CC

UAAU

ACAUGC

A

A

G U CG A

A C G A G C U G C

GCCUAAUGAUAGUUGAUGC

UUGCAUUAGCUUGACUUAAGUU

AGCAGCGAGUGGC

GA

ACUGG

UG

AGU

AACA

CGUGGAU A

ACC

UG

CCCAGAAG

A A G G GG

A U AA C A C C U G G

AA

ACAGAUGCU

AAUA

CCGUAUA

AC

AACGAAAACCA

CAUGGUUUUCGUU

UG

AAAGAUGGCCU

UU G

UG C U A U C G

CUUUUGG

AU

GG

AUCCGCGGC

GCA

UU

AG

CUA

GUU

GG

UG

AGA

UAAAG

G CU

CA

CC

AA

GG

CAAU G A

UG

CG

UA

GCCGACCUG

AG A

GGGUA A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A G

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

AA

A G U C U G A U G G A GCAA U

GC

CG

CGUGAGUG

AAGAA

GGGUUUC

G G C U CGU A A A

A C U CU

GU

UG

UU

AG

AGAAGAAC

GGG

CG

UG

AG

AGUA

A C UG

CU

CA

CG

UC GCGAC G G

UAU

CU

AA

CC

AG

AA

AGUCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGCG

C

AGGCGGUCUUCU

AAGUCUGAUGUG

AAA

CGCUUCGGCU

UA A C C G G A G A A G U G C A U C G G A

AAC U G G G A A A C

UU

GAGUGCAGAA

GA

GGACAGU

GGAACUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A G G A A C

AC C

AG

U GG C G

AA

GGCGGCUGUCU

AGUCUGUAACU

GAC

GCU

G

AGGCUC G

AA

A GCAUGGG

UA G

CAAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUGC C G U

AAAC

GAU

G A G U G C U A GG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CC G

CAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G A C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

UGCUAC G C

GA

AGAA

C C U UA

CCAGGACU

UGA

CA

UC

UU

CU

GCCAAUCUAAGAG

A U U A G A C G U UC

CU

U CGGGGA

CA

GA

A UG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U G U C A U U A G

U U GC C

A GC A U U

AA

GUUGGGCACU

CUAAUGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

AC

GG

UAC

A A C GA

GUU G

CG

A A AC

CG C

GA

GG

UC

AAG

CU

AAU

CU

CU

UAAAG

CC

GU

UCUCA

GU

UCGGAUUGCAGGC

UGC

AACUCGCCUGCAU

GAAGU

UG

GAAUCGC

UAGUAAUCGUGGA U

CA

GCAUG

CC

AC

GG

UGA

AU

ACGU

UCC

CGGGUCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CAAA

GUCGGU

UAGGUA

A CCU

U UUGG

AGCCU

GCCGCCUAA

GGUGGGACAGAUGA

UUAGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A G G AGA

ACCUGCGGCUGGAUCACCUCCUUUNU

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus lindneri (X95421)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus July 2012

NAG A G U U

U GAUNNUGGCUCAG

GA

CGA

AC

GU

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

A C G A G G U C U C

CUAACUGAUAGCUGGUGC

UUGCAUCAGCUUGACGAUAGA

UC

UGACCGAGUGGC

GA

ACUGG

UG

AGU

AACA

CGUGGGU A

ACC

UG

CCCAGAAG

A A G G GG

A U AA C A C C U G G

AA

ACAGAUGCU

AAUA

CCGUAUA

AC

AACGAGAACCA

CAUGGUUCUCGUU

UG

AAAGAUGGCUU

UU AUG C U A U C G

CUUCUGG

AU

GG

ACCCGCGGC

GUA

UU

AG

CUA

GUU

GG

UG

AGA

UAAUA

G CU

CA

CC

AA

GG

CAAU G A

UA

CG

UA

GCAGACCUG

AG A

GGGUA A

UC U GC C

AC

AAUGGGA

CUGA

GA

C A C GG C C C A U

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

AA

A G U C U G A U G G A GCAA C

GC

CG

CGUGAGUG

AAGAA

GGGUUUC

G G C U CGU A A A

A C U CU

GU

UG

UU

AG

AGAAGAAC

GAC

CG

UG

AG

AGCA

A C UG

CU

CA

CG

GU GUGAC G G

UAU

CU

AA

CC

AG

AA

AGUCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

AC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGCG

C

AGGCGGUUUUCU

AAGUCUGAUGUG

AAA

CGCUUCGGCU

UA A C C G G A G A A G U G C A U C G G A

AAC U G G A U A A C

UU

GAGUGCAGAA

AA

GGACAGU

GGAACUUCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G A A G G A A C

AC C

AG

U GG C G

AA

GGCGGCUGUCU

GGUCUGCAUCU

GAC

GCU

G

AGGCUC G

AA

A GCAUGGG

UA G

CAAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUGC C G U

AAAC

GAU

G A A U G C U A GG

UG

UU

GG

GA

GGU U U

CC

GCC

UC

UC

AG

UG

CC G

CAG

C UA

ACG

CAUUA

AGCAUUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G A C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

UGCUAC G C

GA

AGAA

C C U UA

CCAGGACU

UGA

CA

UC

UU

CU

GUUAACCUAAGAG

A U U A G G U G UC

CU

U CGGGGG

CA

GA

A UG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U G U C U U U A G

U U GC C

A GC A U U

AA

GUUGGGCACU

CUAGAGA

G

A

CUGCCGGUG

AUAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGUCCUGGGCU

AC

ACACGUGCUAC A A U

GG

AC

GG

UAC

A A C GA

GUU G

CG

A A AC

CG C

AA

GG

UC

AAG

CU

AAU

CU

CU

UAAAG

CC

GU

UCUCA

GU

UCGGAUUGCAGGC

UGC

AACUCGCCUGCAU

GAAGU

UG

GAAUCGC

UAGUAAUCGUGGA U

CA

GCAUG

CC

AC

GG

UGA

AU

ACGU

UCC

CGGGUCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CAAA

GUCGGU

UGGAUA

A CCU

U U ACGG

AGUCC

GCCGCCUAA

GGUGGGACAGAUGA

UUAGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A G G AGA

ACCUGCGGCUGGAUCACCUCCUUUNU

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus rapi (AB366389)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus July 2012

NAG A G U U

U GAUCCUGGCUCAG

GA

CGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

A C G C G U C U U G

GUUAAAGAUUUUAGGUGC

UUGCAUUUAAAUGAUUUAACA

UUGAGACGAGUGGC

GA

ACUGG

UG

AGU

AACA

CGUGGGU A

ACCU

GC

CCUUGAAG

UA G G GG

A U AA C A C U U G G

AA

ACAGGUGCU

AAUA

CCGUAUA

AC

AACUCAAACCA

CAUGGUUUGAGUU

UG

AAAGAUGGCU

UC

G G C U G U C ACUUUAGG

AU

GG

ACCCGCGGC

GUA

UU

AG

CUU

GUU

GG

UG

AGG

UAACG

G CU

CA

CC

AA

GG

CAAU G A

UA

CG

UA

GCCGACCUG

AG A

GGGUA A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

AA

A G U C U G A U G G A GCAA C

GC

CG

CGUGAGUG

AUGAA

GGGUUUC

G G C U CGU A A A

A C U CU

GU

UG

UU

GG

AGAAGAAC

AGG

UG

UG

AG

AGUA

A C UG

UU

CA

CA

UC UUGAC G G

UAU

CC

AA

CC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGCG

C

AGGCGGUUUUUU

AGGUCUGAUGUG

AAA

GCCUUCGGCU

UA A C C G G A G A A G U G C A U C G G A

AAC C G G G A G A C

UU

GAGUGCAGAA

GA

GGACAGU

GGAACUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUGUCU

GGUCUGUAACU

GAC

GCU

G

AGGCUC G

AA

A GCAUGGG

UA G

CGAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUGC C G U

AAAC

GAU

G A G U G C U A AG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CU G

CAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

UGCUAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

UU

CU

GCCAACCUAAGAG

A U U A G G C G U UCCCU

U CGGGGA

CA

GA

A UG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U A U U G U U A G

U U GC C

A GC A U U

UA

GUUGGGCACU

CUAGCAA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

AC

GG

UAC

A A C GA

GUC G

CG

A A AC

CG C

GA

GG

UC

AAG

CU

AAU

CU

CU

UAAAG

CC

GU

UCUCA

GU

UCGGAUUGUAGGC

UGC

AACUCGCCUACAU

GAAGU

UG

GAAUCGC

UAGUAAUCGUGGA U

CA

GCAUG

CC

AC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CAAA

GCCGGU

GAGGUA

A CCU

U CGGG

AACCA

ACCGUCUAA

GGUGGGACAGAUGA

UUAGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A G G AGA

ACCUGCGGCUGGAUCACCUCCUNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus plantarum(FJ386491)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus June 2012

AUUAAUUUGAG A G U U

U GAUCCUGGCUCAG

GA

CGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

A C G A A C U C U

GGUAUUGAUUGGUGC

UUGCAUCAUGAUUUACAU

UU

GAGUGAGUGGC

GA

ACUGG

UG

AGU

AACA

CGUGGGA A

ACC

UG

CCCAGAAG

CG G G GG

A U AA C A C C U G G

AA

ACAGAUGCU

AAUA

CCGCAUA

AC

AACUUGGACCG

CAUGGUCCGAGCU

UG

AAAGAUGGCU

UC

G G C U A U C ACUUUUGG

AU

GG

UCCCGCGGC

GUA

UU

AG

CUA

GAU

GG

UG

GGG

UAACG

G CU

CA

CC

AU

GG

CAAU G A

UA

CG

UA

GCCGACCUG

AG A

GGGUA A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

AA

A G U C U G A U G G A GCAA C

GC

CG

CGUGAGUG

AAGAA

GGGUUUC

G G C U CGU A A A

A C U CU

GU

UG

UU

AA

AGAAGAAC

AUA

UC

UG

AG

AGUA

A C UG

UU

CA

GG

UA UUGAC G G

UAU

UU

AA

CC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGCG

C

AGGCGGUUUUUU

AAGUCUGAUGUG

AAA

GCCUUCGGCU

CA A C C G A A G A A G U G C A U C G G A

AAC U G G G A A A C

UU

GAGUGCAGAA

GA

GGACAGU

GGAACUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUGUCU

GGUCUGUAACU

GAC

GCU

G

AGGCUC G

AA

A GUAUGGG

UA G

CAAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUAC C G U

AAAC

GAU

G A A U G C U A AG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CU G

CAG

C UA

ACG

CAUUA

AGCAUUC

CGCCU

G G GG

A G U ACG G C C G

CA

AGGCUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCUAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UA

CU

AU

GCAAAUCUAAGAG

A U U A G A C G U UCCCU

U CGGGGA

CA

UG

G AU

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U A U U A U C A G

U U GC C

A GC A U U

AA

GUUGGGCACU

CUGGUGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

AU

GG

UAC

A A C GA

GUU G

CG

A A CU

CG C

GA

GA

GU

AAG

CU

AAU

CU

CU

UAAAG

CC

AU

UCUCA

GU

UCGGAUUGUAGGC

UGC

AACUCGCCUACAU

GAAGU

CG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCAUG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CAAA

GUCGGU

GGGGUA

A CCUU U U

AGG

AACCA

GCCGCCUAA

GGUGGGACAGAUGA

UUAGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A G G AGA

ACCUGCGGCUGGAUCACCUCCUUUCU

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’ Lactobacillus farciminis(AJ417499)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus July 2012

NAG A G U U

U GAUYMUGGCUCAG

GA

CGA

AC

GC

U

GGC

GG

CA

UG

CC

UAAU

ACAUGC

A

A

G U CG A

A C G A A C C A U C

CUGAAGAUUGAAGC

UUGCUUCAUGAUUCAGAC

CU

UGGUGAGUGGC

GG

ACGGG

UG

AGU

AACA

CGUGGGU A

ACC

UG

CCCAAAAG

UG G G GG

A U AA C A U U U G G

AA

ACAAGUGCU

AAUA

CCGCAUA

AC

AACUACUUUCA

CAUGAUCGUAGCU

UG

AAAGAUGGCU

CU G C U A U C G

CUUUUGG

AU

GG

ACCCGCGGC

GUA

UU

AG

CUA

GUU

GG

UG

AGG

UAAUA

G CU

CA

CC

AA

GG

CAAU G A

UA

CG

UA

GCCGACCUG

AG A

GGGUA A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGGCG

AA

A G C C U G A U G G A GCAA U

GC

CG

CGUGAGUG

AAGAA

GGUUUUC

G G A U CGU A A A

A C U CU

GU

UG

UU

GA

AGAAGAAC

AUG

CG

UG

AG

AGUA

A C UG

UU

CA

CG

UA CUGAC G G

UAU

UC

AA

CC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGA

GAAUG

U

AGGCGGUUUAUU

AAGUUUGAAGUG

AAA

GCCCUCGGCU

CA A C C G A G G A A G U G C U U C G A A

AAC U G G U A A A C

UU

GAGUGCAGAA

GA

GGAAAGU

GGAACUCCAUGUGUA

GCGGUGG

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUUUCU

GGUCUGUAACU

GAC

GCU

G

AGA UUC G

AA

A GCAUGGG

UA G

CAAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUGC C G U

AAAC

GAU

G A G U G C U A AG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CU G

CAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG A U C G

CA

AGAUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UA

CC

AU

GACAAACUAAGAG

A U U A G U C U U UCCCU

U CGGGGA

CA

UG

G AU

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U A U U A U C A G

U U GC C

A GC A U U

CA

GUUGGGCACU

CUGGUGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

CGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

UC

GG

UAC

A A C GU

GUU G

CG

A A CU

CG C

GA

GG

GC

AAG

CA

AAU

CA

CU

UAAAA

CC

GA

UCUCA

GU

UCGGAUUGCAGGC

UGC

AACUCGCCUGCAU

GAAGC

UG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCAUG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CAAA

GUCGGU

GGGGUA

A CCCU

U CGGGG

AACUA

GCCGCCUAA

GGUGGGACAAAUGA

UUAGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A G G AGA

ACCUGCGGCUGGAUCACCUCCUUUNUG

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus malefermentans(AM113783)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus July 2012

NNG A G U U

U GAUUCUGGCUCAG

GA

UGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

A C G C A U C C C

GUUGAUUUGAAGUGC

UUGCACUGAUAAUUAACA

UC

GGAUGAGUGGC

GA

ACUGG

UG

AGU

AACA

CGUGGGU A

ACU

UG

CCCAAAAG

UA G G GG

A U AA C A U U U G G

AA

ACAGGUGCU

AAUA

CCGUAUA

AC

AACGAAAAUCG

CAUGAUUUUCGUU

UG

AAAGAUGGUU

UC

G G C U A U C ACUUUUGG

AU

AG

ACCCGCGGU

GCA

UU

AG

CUA

GUU

GG

UA

GAG

UAAUG

G UU

UA

CC

AA

GG

CAAU G A

UG

CA

UA

GCCGACCUG

AG A

GGGUA A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

AA

A G U C U G A U G G A GCAA C

GC

CG

CGUGAGUG

AAGAA

GGGUUUC

G G C U CGU A A A

A C U CU

GU

UG

UU

GG

AGAAGAAC

GAA

CG

UG

AG

AGUA

A C UG

UU

CA

CG

UU GUGAC G G

UAU

CC

AA

CC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UA

UC

CG

GAUUU

AU

U G GGC

GUAA

AGA

GAGUG

C

AGGCGGUUUGUU

AAGUCUGAUGUG

AAA

GCCUUCGGCU

CA A C C G A A G A A G U G C A U U G G A

AAC U G A U A A A C

UU

GAGUGCAGAA

AA

GGACAGU

GGAACUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUGUCU

GGUCUGUAACU

GAC

GCU

G

AGA CUC G

AA

A GCAUGGG

UA G

CGAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUGC C G U

AAAC

GAU

G A A U G C U A AG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CU G

CAG

C UA

ACG

CAUUA

AGCAUUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCUAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

UU

CU

GCCAACCUAAGAG

A U U A G G C G U UCCCU

U CGGGGA

CA

GA

A UG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U A U U A U C A G

U U GC C

A GC A U U

AA

GUUGGGCACU

CUGGUGA

G

A

CUGCCGGUG

AUAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

AC

GG

UAC

A A C GA

GUC G

CG

A A CU

CG C

GA

GG

GU

AAG

CU

AAU

CU

CU

UAAAG

CC

GU

UCUCA

GU

UCGGACUGUAGGC

UGC

AACUCGCCUACAC

GAAGU

UG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCAUG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CAAA

GUCGGU

UCGGUA

A CCU

U CGGG

AGCCA

GCCGCCUAA

GGUGGGACAGAUGA

UUAGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A G G AGA

ACCUGCGGCUGGAUCACCUCCUNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’ Lactobacillus versmoldensis(AJ496791)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus July 2012

NAG A G U U

U GAUNNUGGCUCUG

GA

UGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

G C G A A C U C U G

GUAACUGAUUUUUGAUGC

UUGCAUCAAAAUGAAGAUACAU

UU

GAGUGAGCGGC

GG

AUGGG

UG

AGU

AACA

CGUGGGU A

ACC

UG

CCCUAAAG

UG G G GG

A U AA C A U C U G G

AA

ACAGGUGCU

AAUA

CCGCAUA

AC

AACAACUUCCA

CAUGGAGGAUGUU

UG

AAAGAUGGUU

CU G C U A U C G

CUUUAGG

AU

GG

ACCCGCGGC

GUA

UU

AG

UUA

GUU

GG

UG

AGG

UAAAG

G CU

CA

CC

AA

GA

CGAU G A

UA

CG

UA

GCCGACCUG

AG A

GGGUA A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

AA

A G U C U G A U G G A GCAA C

GC

CG

CGUGAGUG

AAGAA

GGUUUUC

G G A U CGU A A A

A C U CU

GU

UG

UU

GA

AGAAGAAC

AUG

CG

UG

AG

AGUA

A C UG

UU

CA

UG

UA UUGAC G G

UAU

UC

AA

CC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UA

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGUG

C

AGGCGGUUUAUU

AGGUCUGAUGUG

AAA

GCCCUCGGCU

CA A C C G A G G A A G U G C A U C G G A

AAC C G G U A A A C

UU

GAGUGCAGAA

GA

GGAGAGU

GGAACUCCAUGUGUA

GCGGUGG

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUCUCU

GGUCUGUAACU

GAC

GCU

G

AGGCUC G

AA

A GCGUGGG

UA G

CAAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCACGC C G U

AAAC

GAU

G A G U G C U A AG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CU G

CAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UA

CC

AU

GAAAAGCUAAGAG

A U U A G U C U U UCCCU

U CGGGGA

CA

UG

G AU

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U A U U A U C A G

U U GC C

A GC A U U

AA

GUUGGGCACU

CUGGUGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

CGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

UC

GG

UAC

A A C GU

GUU G

CG

A A CU

CG C

GA

GG

GC

AAG

CA

AAU

CA

CU

UAAAA

CC

GA

UCUCA

GU

UCGGAUUGUAGGC

UGC

AACUCGCCUACAU

GAAGC

UG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCAUG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CAAA

GCCGGU

GGGGUA

A CCUU U U

AGG

AGCUA

GCCGUCUAA

GGUGGGACAAAUGA

UUAGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A G G AGA

ACCUGCGGCUGGAUCACCUCCUUUCUA

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus reuteri(AP007281)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus June 2012

NAG A G U U

U GAUCCUGGCUCAG

GA

UGA

AC

GC

C

GGC

GG

UG

UG

CC

UAAU

ACAUGC

A

A

G U CG U

A C G C A C U G GC

CCAACUGAUUGAUGGUGC

UUGCACCUGAUUGACGAUGGAUC

ACCAGUGAGUGGC

GG

ACGGG

UG

AGU

AACA

CGUAGGU A

ACC

UG

CCCCGGAG

CG G G GG

A U AA C A U U U G G

AA

ACAGAUGCU

AAUA

CCGCAUA

AC

AACAAAAGCCA

CAUGGCUUUUGUU

UG

AAAGAUGGCU

UU

G G C U A U C ACUCUGGG

AU

GG

ACCUGCGGU

GCA

UU

AG

CUA

GUU

GG

UA

AGG

UAAUG

G CU

UA

CC

AA

GG

CGAU G A

UG

CA

UA

GCCGAGUUG

AG A

GA C UG A

UC GGC C

AC

AAUGGAA

CUGA

GA

C A C GG U C C A U

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGGCG

CA

A G C C U G A U G G A GCAA C

AC

CG

CGUGAGUG

AAGAA

GGGUUUC

G G C U CGU A A A

G C U CU

GU

UG

UU

GG

AGAAGAAC

GUG

CG

UG

AG

AGUA

A C UG

UU

CA

CG

CA GUGAC G G

UAU

CC

AA

CC

AG

AA

AGUCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UA

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGCG

C

AGGCGGUUGCUU

AGGUCUGAUGUG

AAA

GCCUUCGGCU

UA A C C G A A G A A G U G C A U C G G A

AAC C G G G C G A C

UU

GAGUGCAGAA

GA

GGACAGU

GGAACUCCAUGUGUA

GCGGUGG

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUGUCU

GGUCUGCAACU

GAC

GCU

G

AGGCUC G

AA

A GCAUGGG

UA G

CGAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUGC C G U

AAAC

GAU

G A G U G C U A GG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CC G

GAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCUAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

UU

GC

GCUAACCUUAGAG

A U A A G G C G U UCCCU

U CAGGGA

CG

CA

A UG

AC A

GG

U GGUGC

A UG

GUCGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U G U U A C U A G

U U GC C

A GC A U U

GA

GUUGGGCACU

CUAGUGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

CGA

CGUC

AGAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

AC

GG

UAC

A A C GA

GUC G

CA

A A CU

CG C

GA

GA

GU

AAG

CU

AAU

CU

CU

UAAAG

CC

GU

UCUCA

GU

UCGGACUGUAGGC

UGC

AACUCGCCUACAC

GAAGU

CG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCAUG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGG

GAGUUUGUAACGCC

CAAA

GUCGGU

GGCCUA

A CCU

UU AUGG

AGGGA

GCCGCCUAA

GGCGGGACAGAUGA

CUGGGGUGA

AGU

CGU

AAC

A AG

G

U A N N N N N N N N NNN

NNNNNNNNNNNNNNNNNNNNNNNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus mucosae (AF126738)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus July 2012

NAG A G U U

U GAUCCUGGCUCAG

GA

UGA

AC

GC

C

GGC

GG

UG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

A C G C G U U G G C

CCAACUGAUUGAACGUGC

UUGCACGGACUUGACGUUGGUU

UA

CCAGCGAGUGGC

GG

ACGGG

UG

AGU

AACA

CGUAGGU A

ACC

UG

CCCCAAAG

CG G G GG

A U AA C A U U U G G

AA

ACAGAUGCU

AAUA

CCGCAUA

AC

AAUUUGAAUCG

CAUGAUUCAAAUU

UA

AAAGAUGGCU

UC

G G C U A U C ACUUUGGG

AU

GG

ACCUGCGGC

GCA

UU

AG

CUU

GUU

GG

UA

GGG

UAACG

G CC

UA

CC

AA

GG

CUGU G A

UG

CG

UA

GCCGAGUUG

AG A

GA C UG A

UC GGC C

AC

AAUGGAA

CUGA

GA

C A C GG U C C A U

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGGCG

CA

A G C C U G A U G G A GCAA C

AC

CG

CGUGAGUG

AAGAA

GGGUUUC

G G C U CGU A A A

G C U CU

GU

UG

UU

AG

AGAAGAAC

GUG

CG

UG

AG

AGCA

A C UG

UU

CA

CG

CA GUGAC G G

UAU

CU

AA

CC

AG

AA

AGUCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UA

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGCG

C

AGGCGGUUUGAU

AAGUCUGAUGUG

AAA

GCCUUUGGCU

UA A C C A A A G A A G U G C A U C G G A

AAC U G U C A G A C

UU

GAGUGCAGAA

GA

GGACAGU

GGAACUCCAUGUGUA

GCGGUGG

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUGUCU

GGUCUGCAACU

GAC

GCU

G

AGGCUC G

AA

A GCAUGGG

UA G

CGAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUGC C G U

AAAC

GAU

G A G U G C U A GG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CC G

CAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCUAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

UU

GC

GCCAACCCUAGAG

A U A G G G C G U UUCCU

U CGGGAA

CG

CA

A UG

AC A

GG

U GGUGC

A UG

GUCGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U G U U A C U A G

U U GC C

A GC A U U

CA

GUUGGGCACU

CUAGUGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

CGA

CGUC

AGAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

AC

GG

UAC

A A C GA

GUC G

CG

A A CU

CG C

GA

GG

GC

AAG

CU

AAU

CU

CU

UAAAA

CC

GU

UCUCA

GU

UCGGACUGCAGGC

UGC

AACUCGCCUGCAC

GAAGU

CG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCAUG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGCAACACC

CAAA

GUCGGU

GGGGUA

A CCCU

U CGGGG

AGCUA

GCCGCCUAA

GGUGGGGCAGAUGA

UUAGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A G G AGA

ACCUGCGGCUGGAUCACCUCCUNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus pontis (X76329)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus July 2012

NAG A G U U

U GAUNNUGGCUCAG

GA

UGA

AC

GC

C

GGC

GG

UG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

G C G C A C U G G C

CCAACUGAUAUGACGUGC

UUGCACUGAUUUGACGAUGGAU

UA

CCAGUGAGCGGC

GG

ACGGG

UG

AGU

AACA

CGUGGGC A

ACC

UG

CCCUGGAG

CG G G GG

A U AA C A U U U G G

AA

ACAGAUGCU

AAUA

CCGCAUA

AU

AAUCAAAACCA

CAUGGUUUUGAUU

UC

AAAGAUGGCU

UC

G G C U A U C ACUCCAGG

AU

GG

GCCCGCGGU

GCA

UU

AG

CUA

GUU

GG

UA

AGG

UAACG

G CU

UA

CC

AA

GG

CGAU G A

UG

CA

UA

GCCGAGUUG

AG A

GA C UG A

UC GGC C

AC

AAUGGAA

CUGA

GA

C A C GG U C C A U

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGGCG

CA

A G C C U G A U G G A GCAA C

AC

CG

CGUGAGUG

AAGAA

GGGUUUC

G G C U CGU A A A

A C U CU

GU

UG

UU

GA

AGAAGAAC

GUG

CG

UG

AG

AGUA

A C UG

UU

CA

CG

CA GUGAC G G

UAU

UC

AA

CC

AG

AA

AGUCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UA

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGCG

C

AGGCGGUUACUU

AAGUCUGAUGUG

AAA

CGCUUCGGCU

UA A C C G A A G A A G U G C A U C G G A

AAC U G G G U G A C

UU

GAGUGCAGAA

GA

GGACAGU

GGAACUCCAUGUGAU

GCGGUGG

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUGUCU

GGUCUGCAACU

GAC

GCU

G

AGGCUC G

AA

A GCAUGGG

UA G

CGAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUGC C G U

AAAC

GAU

G A G U G C U A GG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CC G

GAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCUAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

UU

GC

GCUAACCUAAGAG

A U U A G G C G U UCCCU

U CGGGGA

CG

CA

A UG

AC A

GG

U GGUGC

A UG

GUCGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U G U U A C U A G

U U GC C

A GC A U U

CA

GUUGGGCACU

CUAGUGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AGAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

UC

GG

UAC

A A C GA

GUC G

CU

A A CC

CG C

GA

GG

GC

AAG

CU

AAU

CU

CU

UAAAG

CC

GA

UCUCA

GU

UCGGACUGUAGGC

UGC

AACUCGCCUACAC

GAAGU

CG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCAUG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGG

AAGUUUGUAACGCC

CAAA

GUCGGU

GGCCUA

A CCA

U UUGG

AGGGA

GCCGCCUAA

GGCGGGACAGAUGA

CUGGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A G G AGA

ACCUGCGGCUGGAUCACCUCCUUUNU

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactobacillus suebicus (AJ575744)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus July 2012

UUAAG A G U U

U GAUUAUGGCUCAG

GA

UGA

AC

GC

U

GGC

GG

UG

UG

CC

UAAU

ACAUGC

A

A

G U CG U

A C G C A U U C U C

GUUUCUGAUUGACGGUGC

UUGCACCUAAUUGACGAGACA

UUGGAAUGAGUGGC

GG

ACGGG

UG

AGU

AACA

CGUGGGU A

ACC

UG

CCCAGAAG

UG G G GG

A U AA C A U U U G G

AA

ACAGAUGCU

AAUA

CCGCAUA

AA

AGUCAAAACCA

CAUGGUUUUGAUU

UA

AAAGAUGGCCU

UUGU G C U A U C A

CUUCUGG

AU

GG

ACCCGCGGC

GUA

UU

AG

CUA

GUU

GG

UA

AGG

UAACG

G CU

UA

CC

AA

GG

CAAU G A

UA

CG

UA

GCCGAACUG

AG A

GGU UG A

UC GGC C

AC

AAUGGGA

CUGA

GA

C A C GG C C C A U

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGGCG

CA

A G C C U G A U G G A GCAA C

AC

CG

CGUGAGUG

AAGAA

GGGUUUC

G G C U CGU A A A

A C U CU

GU

UG

UU

AA

AGAAGAAC

GUA

UC

UA

AG

AGUA

A C UG

CU

UA

GG

UA GUGAC G G

UAU

UU

AA

CC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UA

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGCG

C

AGGCGGUUUUUU

AAGUCUGAUGUG

AAA

GCCUUCGGCU

UA A C C G A A G A A G U G C A U C G G A

AAC U G G G A G A C

UU

GAGUGCAGAA

GA

GGACAGU

GGAACUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUGUCU

GGUCUGUAACU

GAC

GCU

G

AGGCUC G

AA

A GCAUGGG

UA G

CGAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUGC C G U

AAAC

GAU

G A A U G C U A AG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CU G

CAG

C UA

ACG

CAUUA

AGCAUUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

UA

GC

GCCAAUCUCAGAG

A U G A G A C G U UCCCU

U CGGGGA

CG

CU

A AG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U A U U A U C A G

U U GC C

A GC A U U

CA

GUUGGGCACU

CUGGUGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

CGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

AC

GG

UAC

A A C GA

GUU G

CG

A A CU

CG C

GA

GG

GU

AAG

CU

AAU

CU

CU

UAAAG

CC

GU

UCUCA

GU

UCGGACUGUAGGC

UGC

AACUCGCCUACAC

GAAGU

CG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCAUG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CAAA

GUCGGU

GGGGUA

A CCUU U U

AGG

AGCCA

GCCGCCUAA

GGUGGGACAGAUGA

UUAGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A G G AGA

ACCUGCGGCUGGAUCACCUCCUUU

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

uncultured bacterium (AM500777)1.cellular organisms 2.Bacteria 3.environmental samples 4.uncultured bacterium July 2012

NAG A G U U

U GAUCCUGGCUCAG

GA

CGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U C G AA

CG

AG

UU

UG

CU

UU

UA

AU

GA

AG

AC

GG

UG

CU

UGC

AC

CA

AC

UG

AU

UU

AA

AA

AU

AA

AC

GA

GUGGC

GG

ACGGG

UG

AGU

AACA

CGUGGGU A

ACC

UA

CCCUAAAG

UG G G GG

A U AA C A U U U G G

AA

ACAGAUGCU

AAUA

CCGCAUA

AU

AUUAAAAACCA

CAUGGUUUUUAAU

UG

AAAGACGGCG

UA

A G C U G U C ACUUUUGG

AU

GG

ACCCGCGGC

GUA

UU

AG

CUA

GUU

GG

UG

AGG

UAACG

G CU

UA

CC

AA

GG

CGAU G A

UA

CG

UA

GCCGACCUG

AG A

GGGUG A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

AA

A G U C U G A U G G A GCAA C

GC

CG

CGUGAGUG

AAGAA

GGUUUUC

G G A U CGU A A A

A C U CU

GU

UA

UU

GG

AGAAGAAC

GUA

UU

UG

GU

AGUA

A C UG

GC

CA

GA

UA GUGAC G G

UAU

CC

AA

UC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUGG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGUG

C

AGGCGGUUUUUU

AAGUCUGAUGUG

AAA

GCCUUCGGCU

UA A C C G A A G A C A U G C A U U G G A

AAC U G G G A A A C

UU

GAGUGCAGAA

GA

GGAGAGU

GGAACUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUCUCU

GGUCUGUAACU

GAC

GCU

G

AGGCUC G

AA

A GCGUGGG

UA G

CAAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCACGC C G U

AAAC

GAU

G A G U G C U A AG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CU G

CAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

UA

GC

GCCAAUCCUAGAG

A U A G G A C G U UCCCC

U CGGGGA

CG

CU

A AG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U A U U A U C A G

U U GC C

A GC A U U

CA

GUUGGGCACU

CUGGUGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

CU

AG

UAC

A A C GA

GUU G

CG

A GAC

CG C

GA

GG

UC

AAG

CU

AAU

CU

CU

AAAAG

CU

AG

UCUCA

GU

UCGGAUUGUAGGC

UGC

AACUCGCCUACAU

GAAGU

UG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCACG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CGAA

GCCGGU

GGAGUA

A CCCG

U AAGGG

AGCUA

GCCGUCUAA

GGUGGGACAGAUGA

UUAGGGUGA

AGU

CGU

AAC

A AG

G

U A N N N N N N N N NNN

NNNNNNNNNNNNNNNNNNNNNNNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

uncultured bacterium (AM500848)1.cellular organisms 2.Bacteria 3.environmental samples 4.uncultured bacterium July 2012

NAG A G U U

U GAUCCUGGCUCAG

GA

UGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U C G AA

CG

AG

UU

CU

GG

UU

AA

GA

GU

GG

CG

GU

GCU

UGC

AC

CA

AA

GC

GA

UU

AA

CAAU

GG

AA

CG

AG

UGGC

GG

ACGGG

UG

AGU

AACA

CGUGGGU A

ACC

UA

CCCUAUAG

CA G G GG

A U AA C A U U U G G

AA

ACAGAUGCU

AAUA

CCGCAUA

AC

AACAACUAUCA

CAUGAUAGAUGUU

UG

AAAGAUGGCG

AA

A G C U A U C ACUAAAGG

AU

GG

ACCUGCGGC

GUA

UU

AG

UUA

GUU

GG

UA

AGG

UAACG

G CU

UA

CC

AA

GA

CGAU G A

UA

CG

UA

GCCGACUUG

AG A

GA GUG A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

AA

A G U C U G A U G G A GCAA C

GC

CG

CGUGAGUG

AAGAA

GGGUUUC

G G C U CGU A A A

A C U CU

GU

UA

UU

GG

AGAAGAAG

GAU

AA

GG

UA

AGCA

A C UG

UA

CU

UU

A U UUGAC G G

UAA

CC

AA

UC

AG

AA

AGUCACAGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UA

UC

CG

GAAUU

AU

U G GGC

GUAA

AGC

GAGUG

C

AGGCGGUUGUAU

AAGUCUGAUGUG

AAA

GCCCUCGGCU

CA A C C G A G G A A U U G C A U C A G A

AAC U G U A U A A C

UU

GAGUGCAGAA

GA

GGAGAGU

GGAACUCCAUGUGUA

GCGGUGG

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

AGCGGCUCUCU

GGUCUGUAACU

GAC

GCU

G

AGGCUC G

AA

A GCAUGGG

UA G

CGAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUGC C G U

AAAC

GAU

G A G U G C U A AG

UG

UU

GG

GA

GGU U U

CC

GCC

UC

UC

AG

UG

CU G

GAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

UA

GC

GCCAAUCCCAGAG

A U G G G A C G U UUCCU

U CGGGAA

CG

CU

A AG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U A U U A C U A G

U U GC C

A GC A U U

AA

GAUGGGCACU

CUAGUGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

GC

GG

UAC

A A C GA

GUU G

CG

A A CU

UG U

GA

AA

GU

AAG

CG

AAU

CU

CU

AAAAA

CC

GU

UCUCA

GU

UCGGAUUGUAGGC

UGC

AACUCGCCUACAU

GAAGC

UG

GAAUCGC

UAGUAAUCGUGGA U

CA

GCAUG

CC

AC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAACACC

CAAA

GCCGGU

GAGGUA

A CCAU

U AAUGG

AGCCA

GCCGUCUAA

GGUGGGAUAGAUGA

UUAGGGUGA

AGU

CGU

AAC

A AG

G

U A N N N N N N N N NNN

NNNNNNNNNNNNNNNNNNNNNNNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

uncultured Lactobacillus sp.(HM046576)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus 8.environmental samples June 2012

NAG A G U U

U GAUCCUGGCUCAG

GA

CGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

GC GC GGGA A GU C A GGGA A GC C UU

CGGGUGGAACUGGUGGAACGAGCGGC

GG

AUGGG

UG

AGU

AACA

CGUAGGU A

ACC

UG

CCCUAAAG

CG G G GG

A U AC C A U C U G G

AA

ACAGGUGCU

AAUA

CCGCAUA

AA

CCCAGCAGUCA

CAUGAGUGCUGGU

UG

AAAGACGGCU

UC

G G C U G U C ACUUUAGG

AU

GG

ACCUGCGGC

GUA

UU

AG

CUA

GUU

GG

UG

GAG

UAACG

G UU

CA

CC

AA

GG

CAAC G A

UA

CG

UA

GCCGACCUG

AG A

GGGUA A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

CA

A G U C U G A U G G A GCAA C

GC

CG

CGUGGAUG

AAGAA

GGUCUUC

G G A U CGU A A A

A U C CU

GU

UG

UU

GA

AGAAGAAC

GGU

UG

UG

AG

AGUA

A C UG

CU

CA

UA

GC GUGAC G G

UAA

UC

AA

CC

AG

AA

AGUCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGG

GAGCG

C

AGGCGGUCUUUU

AAGUCUG

AAUGUG

AAA

GCCCUCAGCU

UA A C U G A G G A A G A G C A U C G G A

AAC U G A G A G A C

UU

GAGUGCAGAA

GA

GGAGAGU

GGAACUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUCUCU

GGUCUGUUACU

GAC

GCU

G

AGGCUC G

AA

A GCAUGGG

UA G

CGAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUGC C G U

AAAC

GAU

G A G U G C U A AG

UG

UU

GG

GA

GGU U U

CC

GCC

UC

UC

AG

UG

CU G

CAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

CC

CU

GCAAGCCUAAGAG

A U U A G G G G U UCCCU

U CGGGGA

CA

GG

A AG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U G U U A C U A G

U U GC C

A GC A U U

GA

GUUGGGCACU

CUAGUGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

CGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

AU

GG

UAC

A A U GA

GAA G

CG

A A CU

CG C

GA

GG

GG

AAG

CU

GAU

CU

CU

GAAAA

CC

AU

UCUCA

GU

UCGGAUUGCAGGC

UGC

AACUCGCCUGCAU

GAAGC

UG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCAUG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUCUGUAAUACC

CAAA

GCCGGU

AAGAUA

A CCUG

C AAAGG

AGUCA

GCCGUCUAA

GGUAGGACAGAUGA

UUAGGGUGA

AGU

CGU

AAC

A AG

G

U A G C N N N N N N NNN

NNNNNNNNNNNNNNNNNNNNNNNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

uncultured Lactobacillus sp.(HM046568)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus 8.environmental samples June 2012

NAG A G U U

U GAUCCUGACUCAG

GA

CGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

GC GA GC A A A GU U A A A GGA A U A C UU

CGGUAGGAAUUUAAUAGCGCGAGCGGC

GG

AUGGG

UG

AGU

AACA

CGUGGGC A

AUC

UA

CCCUUUAG

CU U G GG

A U AC C A C U U G G

AA

ACAGGUGCU

AAUA

CCAAAUA

AG

AAGUAAGAGCG

CAUGCUCAAGCUA

UG

AAAGGCGGCUU

UC

G A G C U G U C ACUAAAGG

AU

GA

GCCCGCGGU

GCA

UU

AG

CUA

GUU

GG

UA

AGG

UAACG

G CU

UA

CC

AA

GG

CAAU G A

UG

CA

UA

GCCGAGUUG

AG A

GA C UG A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

CA

A G U C U G A U G G A GCAA C

GC

CG

CGUGAGUG

AAGAA

GGUUUUC

G G A U CGU A A A

A C U CU

GU

UG

UU

GG

UGAGGAAG

GAC

AU

GG

AU

AGUA

A C UG

AU

CU

AU

GU UUGAC G G

UAA

UC

AA

CC

AG

AA

AGUCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAACG

C

AGGCGGGAGAAC

AAGUCAGCUGUG

AAA

GCCCUCGGCU

UA A C C G A G G A A C G G C A A C U G A

AAC U G U U U U U C

UU

GAGUGCAGAA

GA

GGAGAGU

GGAACUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUCUCU

GGUCUGUAACU

GAC

GCU

G

AGGUUC G

AA

A GCAUGGG

UA G

CGAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUGC C G U

AAAC

GAU

G A G U G C U A AG

UG

UU

GG

GA

GGU U U

CC

GCC

UC

UC

AG

UG

CU G

CAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUAAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAGC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

UA

GU

GCCAACCCUAGAG

A U A G G G U G U UUCCU

U CGGGAA

CA

CU

A AG

AC A

GG

U GGUGC

A UG

GCUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U A U U A U U A G

U U GC C

A GC A U U

AA

GUUGGGCACU

CUAAUGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

CGA

CGUC

AAGUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

UU

AG

UAC

A A C GA

GGA G

CG

A A CC

UG U

GA

AG

GC

AAG

CG

AAU

CU

CU

UAAAG

CU

AA

UCUCA

GU

UCGGAUUGCACUC

UGC

AACUCGAGUGCAU

GAAGC

UG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCAUG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUUUGUAAUACC

CAAA

GCCGGU

GAGAUA

A CCUG

U AAAGG

AGUCA

GCCGUCUAA

GGUAGGACAGAUGA

UUAGGGUGA

AGU

CGU

AAC

A AG

G

U A G C N N N N N N NNN

NNNNNNNNNNNNNNNNNNNNNNNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

uncultured Lactobacillus sp.(AY370183)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Lactobacillaceae 7.Lactobacillus 8.environmental samples June 2012

GAG A G U U

U GAUCCUGGCUCAG

GA

CGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

GC GA GC A A U U U U A A U GGA A U A C UU

CGGUAGGAAGUUAAGAGCGCGAGCGGC

GG

AUGGG

UG

AGU

AACA

CGUGGGC A

ACC

UG

CCCUUUAG

CU U G GG

A U AC C A C U U G G

AA

ACAGGUGCU

AAUA

CCAAAUA

AG

AAGCGAGAGCG

CAUGCUCAAGCAG

UA

AAAGGCGGCUU

UC

G A G C U G U C ACUAAAGG

AU

GG

GCCCGCGGU

GCA

UU

AG

CUA

GUU

GG

UA

AGG

UAACG

G CC

UA

CC

AA

GG

CGAU G A

UG

CA

UA

GCCGAGUUG

AG A

GA C UG A

CC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCA

CAAUGGACG

CA

A G U C U G A U G G A GCAA U

GC

CG

CGUGAGUG

AAGAA

GGUUUUC

G G A U CGU A A A

G C U CU

GU

UG

UU

GG

UGAAGAAG

GAC

AA

GG

GU

AGUA

A C UG

AU

CU

UU

GU UUGAC G G

UAA

UC

AA

CC

AG

AA

AGUCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAACG

C

AGGCGGGAAGAU

AAGUCAGCUGUG

AAA

GCCCCCAGCU

UA A C U G G G G A A C U G C A G C U G A

AAC U A U G U U U C

UU

GAGUGCAGAA

GA

GGAGAGU

GGAACUCCAUGUGUA

GCGGUGG

A A U G CG

UA G

AUA U A U G G A A G A A C

AC C

AG

U GG C G

AA

GGCGGCUCUCU

GGUCUGUAACU

GAC

GCU

G

AGGUUC G

AA

A GCAUGGG

UA G

CGAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCAUGC C G U

AAAC

GAU

G A G U G C U A AG

UG

UU

GG

GA

GGU U U

CC

GCC

UC

UC

AG

UG

CU G

CAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUAAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

UA

GU

GCCAGUCCUAGAG

A U A G G A U G U UUCCU

U CGGGAA

CA

CU

A AG

AC A

GG

U GGUGC

A UG

GCUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U A U U A U U A G

U U GC C

A GC A U U

AA

GUUGGGCACU

CUAAUGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

CGA

CGUC

AAGUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

UU

AG

UAC

A A C GA

GCA G

CG

A A CC

UG C

AA

AG

GC

AAG

CG

AAU

CU

CU

GAAAG

CU

AA

UCUCA

GU

UCGGAUUGCACUC

UGC

AACUCGAGUGCAU

GAAGC

UG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCACG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCAUGA

GAGUCUGUAAUGCC

CAAA

GCCGGU

GGGAUA

A CCUG

C AAAGG

AGUCA

GCCGUCUAA

GGCAGGACAGAUGA

UUAGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A G N NNN

NNNNNNNNNNNNNNNNNNNNNNNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Bacillus coagulans (AF466695)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Bacillales 6.Bacillaceae 7.Bacillus June 2012

NAG A G U U

U GAUCCUGGCUCAG

GA

CGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG U

G C G G A C C U U U U A A A A G CUU

GCUUUUAAAAGGUUAGCGGC

GG

ACGGG

UG

AGU

AACA

CGUGGGC A

ACC

UG

CCUGUAAG

A U C G GG

A U AA C G C C G G G

AA

ACCGGGGCU

AAUA

CCGGAUA

GU

UUUUUCCUCCG

CAUGGAGGAAAAA

GG

AAAGACGGCU

UC

G G C U G U C ACUUACAG

AU

GG

GCCCGCGGC

GCA

UU

AG

CUU

GUU

GG

UG

GGG

UAACG

G CU

CA

CC

AA

GG

CAAC G A

UG

CG

UA

GCCGACCUG

AG A

GGGUG A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCG

CAAUGGACG

AA

A G U C U G A C G G A GCAA C

GC

CG

CGUGAGUG

AAGAA

GGCCUUC

G G G U CGU A A A

A C U CU

GU

UG

CC

GG

GGAAGAAC

AAG

UG

CC

GU

UCGAA C A

GG

GC

GG

CG

CC UUGAC G G

UAC

CC

GG

CC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAAUU

AU

U G GGC

GUAA

AGC

GCGCG

C

AGGCGGCUUCUU

AAGUCUGAUGUG

AAA

UCUUGCGGCU

CA A C C G C A A G C G G U C A U U G G A

AAC U G G G A G G C

UU

GAGUGCAGAA

GA

GGAGAGU

GGAAUUCCACGUGUA

GCGGUGA

A A U G CG

UA G

AGA U G U G G A G G A A C

AC C

AG

U GG C G

AA

GGCGGCUCUCU

GGUCUGUAACU

GAC

GCU

G

AGGCGC G

AA

A GCGUGGG

GA G

CAAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCACGC C G U

AAAC

GAU

G A G U G C U A AG

UG

UU

AG

AG

GGU U U

CC

GCC

CU

UU

AG

UG

CU G

CAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG G C C G

CA

AGGCUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

CU

CU

GACCUCCCUGGAG

A C A G G G C C U UCCCCU

U CGGGGGA

CA

GA

G UG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U G A C C U U A G

U U GC C

A GC A U U

CA

GUUGGGCACU

CUAAGGU

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

AU

GG

UAC

A A A GG

GCU G

CG

A GAC

CG C

GA

GG

UU

AAG

CC

AAU

CC

CA

GAAAA

CC

AU

UCCCA

GU

UCGGAUUGCAGGC

UGC

AACCCGCCUGCAU

GAAGC

CG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCAUG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCACGA

GAGUUUGUAACACC

CGAA

GUCGGU

GAGGUA

A CC

UU U A

CGG

AGCCA

GCCGCCGAA

GGUGGGACAGAUGA

UUGGGGUGA

AGU

CGU

AAC

A AG

G

U A N N N N N N N N NNN

NNNNNNNNNNNNNNNNNNNNNNNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Clostridium aff. innocuum CM970 (AF028352)1.cellular organisms 2.Bacteria 3.Tenericutes 4.Mollicutes 5.unclassified Mollicutes June 2012

NNN A G U U

U GAUCCUGGCUCAG

GA

UGA

AC

GC

U

GGC

GG

CA

UG

CC

UAAU

ACAUGC

A

A

G U CG A

A C G A A G U C U CA A

G G A G CUU

GCUCCAAA

GAGACUUAGUGGC

GA

ACGGG

UG

AGU

AACA

CGUAGGU A

ACC

UG

CCCAUGUG

UC C G GG

A U AA C U G C U G G

AA

ACGGUAGCU

AAAA

CCGGAUA

GG

UAUACAGAGCG

CAUGCUCAGUAUA

UU

AAAGCGCCCA

UC

A A G G C G U GAACAUGG

AU

GG

ACCUGCGGC

GCA

UU

AG

CUA

GUU

GG

UG

AGG

UAACG

G CC

CA

CC

AA

GG

CGAU G A

UG

CG

UA

GCCGGCCUG

AG A

GGGUA A

AC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUUU

UCGU

CAAUGGGGG

AA

A C C C U G A A C G A GCAA U

GC

CG

CGUGAGUG

AAGAA

GGUCUUC

G G A U CGU A A A

G C U CU

GU

UG

UA

AG

UGAAGAAC

GGC

UC

AU

AG

AGGA

A A UG

CU

AU

GG

GA GUGAC G G

UAG

CU

UA

CC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UA

UC

CG

GAAUC

AU

U G GGC

GUAA

AGG

GUGCG

U

AGGUGGCGUACU

AAGUCUGUAGUA

AAA

GGCAAUGGCU

CA A C C A U U G U A A G C U A U G G A

AAC U G G U A U G C

UG

GAGUGCAGAA

GA

GGGCGAU

GGAAUUCCAUGUGUA

GCGGUAA

A A U G CG

UA G

AUA U A U G G A G G A A C

AC C

AG

U GG C G

AA

GGCGGUCGCCU

GGUCUGUAACU

GAC

A CU

G

AGGCA C G

AA

A GCGUGGG

GA G

CAAAUAGG

AUU

A G AUAC

CCUA

GUA

GU

CCACGC C G U

AAAC

GAU

G A G A A C U A AG

UG

UU

GG

AG G

AA

UU

CA

GU

GC

U GCAG

U UA

ACG

CAAUA

AGUUCUC

CGCCU

G G GG

A G U AUG C A C G

CA

AGUGUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGUAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGCCU

UGA

CA

UG

GA

AAC

AAAUACCCUAGAG

A U A G G G G G AUA

A UUAU

GG

AU

C AC

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U G U C G C A U G

U U AC C

A GC A U C

AA

GUUGGGGACU

CAUGCGA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGGCCUGGGCU

AC

ACACGUACUAC A A U

GG

CG

AC

CAC

A A A GA

GCA G

CG

A C UU

GG U

GA

CA

AG

AAG

CG

AAU

CU

CA

UAAAG

GU

CG

UCUCA

GU

UCGGAUUGAAGUC

UGC

AACUCGACUUCAU

GAAGU

CG

GAAUCGC

UAGUAAUCGCAGA U

CA

GCAUG

CU

GC

GG

UGA

AU

ACGU

UCU

CGGGCCUUGUA

CACACCGCCCG

UC

AAACCAUGG

GAGUCAGUAAUACC

CGAA

GCCGGU

GGCAUA

A CCG

U AGGG

AUGGA

GCCGUCGAA

GGUAGGACCGAUGA

CUGGGGUUA

AGU

CGU

AAC

A AG

G

U A A C C N N N N N NNN

NNNNNNNNNNNNNNNNNNNNNNNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Enterococcus faecium (EF533987)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Enterococcaceae 7.Enterococcus June 2012

NAG A G U U

U GAUCCUGGCUCAG

GA

CGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

A C G C U U C U U U U U CC

A CCG G A G C

UU

GCUCCACCG

GAAAAAGAGGAGUGGC

GA

ACGGG

UG

AGU

AACA

CGUGGGU A

ACC

UG

CCCAUCAG

A A G G GG

A U AA C A C U U G G

AA

ACAGGUGCU

AAUA

CCGUAUA

AC

AAUCAAAACCG

CAUGGUUUUAAUU

UG

AAAGGCGCUU

UC

G G G U G U C GCUGAUGG

AU

GG

ACCCGCGGU

GCA

UU

AG

CUA

GUU

GG

UG

AGG

UAACG

G CU

CA

CC

AA

GG

CCAC G A

UG

CA

UA

GCCGACCUG

AG A

GGGUG A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCGG

CAAUGGACG

AA

A G U C U G A C C G A GCAA C

GC

CG

CGUGAGUG

AAGAA

GGUUUUC

G G A U CGU A A A

A C U CU

GU

UG

UU

AG

AGAAGAAC

AAG

GA

UG

AG

AGUA

A C UG

UU

CA

UC

CC UUGAC G G

UAU

CU

AA

CC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGCG

C

AGGCGGUUUCUU

AAGUCUGAUGUG

AAA

GCCCCCGGCU

CA A C C G G G G A G G G U C A U U G G A

AAC U G G G A G A C

UU

GAGUGCAGAA

GA

GGAGAGU

GGAAUUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A G G A A C

AC C

AG

U GG C G

AA

GGCGGCUCUCU

GGUCUGUAACU

GAC

GCU

G

AGGCUC G

AA

A GCGUGGG

GA G

CAAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCACGC C G U

AAAC

GAU

G A G U G C U A AG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

CC

AG

UG

CU G

CAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

CU

UU

GACCACUCUAGAG

A U A G A G C U U CCCCU

U CGGGGG

CA

AA

G UG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U A U U G U U A G

U U GC C

A UC A U U

CA

GUUGGGCACU

CUAGCAA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

GA

AG

UAC

A A C GA

GUC G

CG

A A GU

CG C

GA

GG

CU

AAG

CU

AAU

CU

CU

UAAAG

CU

UC

UCUCA

GU

UCGGAUUGCAGGC

UGC

AACUCGCCUGCAU

GAAGC

CG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCACG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCACGA

GAGUUUGUAACACC

CGAA

GUCGGU

GAGGUA

A CC

UU U U

UGG

AGCCA

GCCGCCUAA

GGUGGGAUAGAUGA

UUGGGGUGA

AGU

CGU

AAC

A AG

G

U A N N N N N N N N NNN

NNNNNNNNNNNNNNNNNNNNNNNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Enterococcus hirae (NR_037082)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Enterococcaceae 7.Enterococcus June 2012

NNN N N N N

N NNNCCUGGCUCAG

GA

CGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

A C G C U U C U U U U U CC

A CCG G A G C

UU

GCUCCA

CCGGAAAAAGAGGAGUGGC

GA

ACGGG

UG

AGU

AACA

CGUGGGU A

ACC

UG

CCCAUCAG

A A G G GG

A U AA C A C U U G G

AA

ACAGGUGCU

AAUA

CCGUAUA

AC

AAUCGAAACCG

CAUGGUUUUGAUU

UG

AAAGGCGCUU

UC

G G G U G U C GCUGAUGG

AU

GG

ACCCGCGGU

GCA

UU

AG

CUA

GUU

GG

UG

AGG

UAACG

G CU

CA

CC

AA

GG

CGAC G A

UG

CA

UA

GCCGACCUG

AG A

GGGUG A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCGG

CAAUGGACG

AA

A G U C U G A C C G A GCAA C

GC

CG

CGUGAGUG

AAGAA

GGUUUUC

G G A U CGU A A A

A C U CU

GU

UG

UU

AG

AGAAGAAC

AAG

GA

UG

AG

AGUA

A C UG

UU

CA

UC

CC UUGAC G G

UAU

CU

AA

CC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGCG

C

AGGCGGUUUCUU

AAGUCUGAUGUG

AAA

GCCCCCGGCU

CA A C C G G G G A G G G U C A U U G G A

AAC U G G G A G A C

UU

GAGUGCAGAA

GA

GGAGAGU

GGAAUUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A G G A A C

AC C

AG

U GG C G

AA

GGCGGCUCUCU

GGUCUGUAACU

GAC

GCU

G

AGGCUC G

AA

A GCGUGGG

GA G

CAAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCACGC C G U

AAAC

GAU

G A G U G C U A AG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CU G

CAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

CU

UU

GACCACUCUAGAG

A U A G A G C U U CCCCU

U CGGGGG

CA

AA

G UG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U A U U G U U A G

U U GC C

A UC A U U

UA

GUUGGGCACU

CUAGCAA

G

A

CUGCCGGUG

ACAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

GA

AG

UAC

A A C GA

GUC G

CA

A A GU

CG C

GA

GG

CU

AAG

CU

AAU

CU

CU

UAAAG

CU

UC

UCUCA

GU

UCGGAUUGUAGGC

UGC

AACUCGCCUACAU

GAAGC

CG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCACG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCACGA

GAGUUUGUAACACC

CGAA

GUCGGU

GAGGUA

A CCU

U UUGG

AGCCA

GCCGCCUAA

GGUGGGAUAGAUGA

UUGGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A U C GGA

AGGUGCGGCUGGAUCANNNNNNNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Enterococcus moraviensis (NR_028794)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Enterococcaceae 7.Enterococcus June 2012

NNN N N N N

U GAUCCUGGCUCAG

GA

CGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

A C G C U U C U U U U C UA

C CGA G U G C

UU

GCACUCAUU

UGAAAAGAGGAGUGGC

GG

ACGGG

UG

AGU

AACA

CGUGGGU A

ACC

UA

CCCAUCAG

A G G G GG

A U AA C A C U U G G

AA

ACAGGUGCU

AAUA

CCGCAUA

AU

AGUCGACACCG

CAUGGUGUUGAUU

UG

AAAGACGCUU

UC

G G G U G U C ACUGAUGG

AU

GG

ACCCGCGGU

GCA

UU

AG

CUA

GUU

GG

UG

AGG

UAACG

G CU

CA

CC

AA

GG

CCAU G A

UG

CA

UA

GCCGACCUG

AG A

GGGUG

UC GGC C

AC

ACUGGGA

CUGA

GA

C A C GG C C C A G

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCGG

CAAUGGACG

AA

A G U C U G A C C G A GCAA C

GC

CG

CGUGAGUG

AAGAA

GGUUUUC

G G A U CGU A A A

A C U CU

GU

UG

UU

AG

AGAAGAAC

AAG

UA

GG

AG

AGUA

A C UG

CU

CU

UA

CC UUGAC G G

UAU

CU

AA

CC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGCG

C

AGGCGGUUUCUU

AAGUCUGAUGUG

AAA

GCCCCCGGCU

CA A C C G G G G A G G G U C A U U G G A

AAC U G G G A G A C

UU

GAGUGCAGAA

GA

GGAGAGU

GGAAUUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A G G A A C

AC C

AG

U GG C G

AA

GGCGACUCUCU

GGUCUGUAACU

GAC

GCU

G

AGGCUC G

AA

A GCGUGGG

GA G

CAAACAGG

AUU

A G AUMC

CCUG

GUA

GU

CCACGC C G U

AAAC

GAU

G A G U G C U A AG

UG

UU

GG

AG

GGU U U

CC

GCC

CU

UC

AG

UG

CU G

CAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

CU

UU

GACCACUCUAGAG

A U A G A G C U U UCCCU

U CGGGGA

CA

AA

G UG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U A U U G U U A G

U U GC C

A UC A U U

UA

GUUGGGCACU

CUAGCGA

G

A

CUGCCGGUG

ACAAACCGKAGGAAAGGUGGGGA

UGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

GA

AG

UAC

A A C GA

GUC G

CU

A GGC

CG C

GA

GG

UC

AUG

CA

AAU

CU

CU

UAAAG

CU

UC

UCUCA

GU

UCGGAUUGUAGGC

UGC

AACUCGCCUACAU

GAAGC

CG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCACG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCSSCCG

UC

ACACCACGA

AAGUUUGUAACACC

CGAA

GUCGGU

GAGGUA

A CC

CU U G

UGG

AGCCA

GCCGCCUAA

GGUGGGAUAGAUGA

UUGGGACGA

AGU

CGU

AAC

AC

N

N N N N N N N N N N NNN

NNNNNNNNNNNNNNNNNNNNNNNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Lactococcus lactis subsp. lactis KF147 (NC_013656)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Streptococcaceae 7.Lactococcus 8.Lactococcus lactis 9.Lactococcus lactis subsp. lactis June 2012

GAG A G U U

U GAUCCUGGCUCAG

GA

CGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U UG A

G C G C U GA A

G G U U G G U A CUU

GUACCGACUGG

AUGAGCAGC

GA

ACGGG

UG

AGU

AACG

CGUGGGGA

AUC

UG

CCUUUGAG

CG G G GG

A C AA C A U U U G G

AA

ACGAAUGCU

AAUA

CCGCAUA

AA

AACUUUAAACA

CAAGUUUUAAGUU

UG

AAAGAUGCA

AU

U G C A U C ACUCAAAG

AU

GA

UCCCGCGUU

GUA

UU

AG

CUA

GUU

GG

UG

AGG

UAAAG

G CU

CA

CC

AA

GG

CGAU G A

UA

CA

UA

GCCGACCUG

AG A

GGGUG A

UC GGC C

AC

AUUGGGA

CUGA

GA

C A C GG C C C A A

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCGG

CAAUGGACG

AA

A G U C U G A C C G A GCAA C

GC

CG

CGUGAGUG

AAGAA

GGUUUUC

G G A U CGU A A A

A C U CU

GU

UG

GU

AG

AGAAGAAC

GUU

GG

UG

AG

AGUGG A A

AG

CU

CA

UC

A A GUGAC G G

UAA

CU

AC

CC

AG

AA

AGGGACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUCCCGA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGCG

C

AGGUGGUUUAUU

AAGUCUGGUGUA

AAA

GGCAGUGGCU

CA A C C A U U G U A U G C A U U G G A

AAC U G G U A G A C

UU

GAGUGCAGGA

GA

GGAGAGU

GGAAUUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A G G A A C

AC C

GG

U GG C G

AA

AGCGGCUCUCU

GGCCUGUAACU

GAC

A CU

G

AGGCUC G

AA

A GCGUGGG

GA G

CAAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCACGC C G U

AAAC

GAU

G A G U G C U A GA

UG

UA

GG

GA

GCU A U

AAG

UU

CU

CU

GU

AU

C GCAG

C UA

ACG

CAAUA

AGCACUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UA

CU

CGU

GCUAUUCCUAGAG

A U A G G A A G UUCCU

U CGGGACA

CG

GG A

UA

C AGG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C C U A U U G U U A G

U U GC C

A UC A U U

AA

GUUGGGCACU

CUAACGA

G

A

CUGCCGGUG

AUAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

AU

GG

UAC

A A C GA

GUC G

CG

A GAC

AG U

GA

UG

UU

UAG

CU

AAU

CU

CU

UAAAA

CC

AU

UCUCA

GU

UCGGAUUGUAGGC

UGC

AACUCGCCUACAU

GAAGU

CG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCACG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCACGG

GAGUUGGGAGUACC

CGAA

GUAGGU

UGCCUA

A CCG

C AAGG

AGGGC

GCUUCCUAA

GGUAAGACCGAUGA

CUGGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A U C GGA

AGGUGCGGCUGGAUCACCUNNNNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Listeria rocourtiae (FJ557241)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Bacillales 6.Listeriaceae 7.Listeria June 2012

NNG A G U U

U GAUCAUGGCUCAG

GA

CGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U CG A

A C G A A CC G

A C G A A A G A G CUU

GCUCUUUCUGAC

GUUAGUGGC

GG

ACGGG

UG

AGU

AACA

CGUGGGC A

ACC

UG

CCUGUAAG

UU G G GG

A U AA C U C C G G G

AA

ACCGGGGCU

AAUA

CCGAAUA

AU

AACAAGCGUCG

CAUGACGCCUGUU

UG

AAAGACGGUU

UC

G G C U G U C ACUUACAG

AU

GG

GCCCGCGGU

GCA

UU

AG

CUA

GUU

GG

UA

GGG

UAAUG

G CC

UA

CC

AA

GG

CGAC G A

UG

CA

UA

GCCGACCUG

AG A

GGGUG A

UC GGC C

AC

ACUGGGA

CUGA

GA

C A C GG C C C A G

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCCG

CAAUGGACG

AA

A G U C U G A C G G A GCAA C

GC

CG

CGUGUGUG

AAGAA

GGUUUUC

G A A U CGU A A A

G C A CU

GU

UG

UU

AG

AGAAGAAC

AAG

GA

UA

AG

AGUA

A C UG

CU

UG

UC

CC UUGAC G G

UAU

CU

AA

CC

AG

AA

AGCCACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUGGCAA

GC

GU

UG

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGCG

C

AGGCGGUUUCUU

AAGUCUGAUGUG

AAA

GCCCCCGGCU

UA A C C G G G G A G G G U C A U U G G A

AAC U G A G A G A C

UU

GAAUGCAGGA

GA

GGUAAGU

GGAAUUCCACGUGUA

GCGGUGA

A A U G CG

UA G

AUA U G U G G A G G A A C

AC C

AG

U GG C G

AA

GGCGGCUUACU

GGCCUGUAAUU

GAC

GCU

G

AGGCUC G

AA

A GCGUGGG

GA G

CAAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCACGC C G U

AAAC

GAU

G A G U G C U A AG

UG

UU

AG

GG

GGU U U

CC

GCC

CC

UU

AG

UG

CU G

CAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GUGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

CU

UU

GAACCUUCUGGAG

A C A G A A C U U UCCCU

U CGGGGA

CA

AA

G UG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C U U G A U U U U A G

U U GC C

A GC A U U

UA

GUUGGGCACU

CUAAAGU

G

A

CUGCCGGUG

CAAGCCGGAGG

AAGGUGGGGA

UGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

AU

AA

UAC

A A A GG

GUU G

CC

A A AC

CG C

GA

GG

UC

GAG

CU

AAU

CC

CA

UAAAA

UU

AU

UCUCA

GU

UCGGAUUGUAGGC

UGC

AACUCGCCUACAU

GAAGC

CG

GAAUCAC

UAGUAAUCGUGGA U

CA

GCAUG

CC

AC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCACGA

GAGUUUGUAACACC

CGAA

GUCGGU

AGGGUA

A CC

UU U A

UGG

AGCCA

GCCGCCGAA

GGUGGGACAGAUAA

UUGGGGUGA

AGU

CGU

AAC

A AG

G

U A G C C G U A U C GGA

AGGUGCGGUUGGAUCACCUNNNNN

Citation and related information available at http://www.rna.ccbb.utexas.edu

Secondary Structure: small subunit ribosomal RNA

5’

3’

Streptococcus parasanguinis ATCC 15912 (NR_024842)1.cellular organisms 2.Bacteria 3.Firmicutes 4.Bacilli 5.Lactobacillales 6.Streptococcaceae 7.Streptococcus 8.Streptococcus parasanguinis June 2012

NNN N N N U

U GAUCCUGGCUCAG

GA

UGA

AC

GC

U

GGC

GG

CG

UG

CC

UAAU

ACAUGC

A

A

G U AG A

A C G C U GA A

G C U U G G U G CUU

GCACCGAGCGG

AGGAGUUGC

GA

ACGGG

UG

AGU

AACG

CGUAGGU A

ACC

UG

CCUCUUAG

CG G G GG

A U AA C U A U U G G

AA

ACGAUAGCU

AAUA

CCGCAUA

AA

AGUCGACAUUG

CAUGAUGUUGACU

UG

AAAGGUGCA

AA

U G C A U C ACUAAGAG

AU

GG

ACCUGCGUU

GUA

UU

AG

CUA

GUU

GG

UG

AGG

UAACG

G CU

CA

CC

AA

GG

CGAC G A

UM

CA

UA

GCCGACCUG

AG A

GGGUG A

UC GGC C

AC

ACUGGGA

CUGA

GA

C A C GG C C C A G

AC

UC

CUA

C GG

GA

GG C A G

CAGUA

GGGAAUCU

UCGG

CAAUGGACG

GA

A G U C U G A C C G A GCAA C

GC

CG

CGUGAGUG

AAGAA

GGUUUUC

G G A U CGU A A A

G C U CU

GU

UG

UA

AG

AGAAGAAC

GAG

UG

UG

AG

AGUGGA A

AG

UU

CA

CA

CU GUGAC G G

UAA

CU

UA

CC

AG

AA

AGGGACGGC

U A ACUACG

UGCCA

GC

AG C C

GC G

GUAA

UAC

GUAG

GUCCCGA

GC

GU

UR

UC

CG

GAUUU

AU

U G GGC

GUAA

AGC

GAGCG

C

AGGCGGUUAGAU

AAGUCUGAAGUU

AAA

GGCUGUGGCU

UA A C C A U A G U A C G C U U U G G A

AAC U G U U U A A C

UU

GAGUGCAGAA

GG

GGAGAGU

GGAAUUCCAUGUGUA

GCGGUGA

A A U G CG

UA G

AUA U A U G G A G G A A C

AC C

GG

U GG C G

AA

AGCGGCUCUCU

GGUCUGUAACU

GAC

GCU

G

AGGCUC G

AA

A GCGUGGG

GA G

CAAACAGG

AUU

A G AUAC

CCUG

GUA

GU

CCACGC C G U

AAAC

GAU

G A G U G C U A GG

UG

UU

GG

GU

CCU U U

CC

GGG

AC

UC

AG

UG

CC G

CAG

C UA

ACG

CAUUA

AGCACUC

CGCCU

G G GG

A G U ACG A C C G

CA

AGGUUGAAA

CUCA

AAG G A A U U G A C G

GG G G C C C G

CA C A A GCGGU

GGAGCAUGUGGUU

UAAU

UC

GA

AGCAAC G C

GA

AGAA

C C U UA

CCAGGUCU

UGA

CA

UC

CC

UCU

GACCGCUCUAGAG

A U A G A G C U UUCCU

U CGGGAC

AG

AG

G UG

AC A

GG

U GGUGC

A UG

GUUGUCG

UCA

GCUCGUGUCG

UGAGAU

GU

UGGG

UU

A AGU

CCCG C

AA C G A G C

GC A A

CC C C U A U U G U U A G

U U GC C

A UC A U U

UA

GUUGGGCACU

CUAGCGA

G

A

CUGCCGGUA

AUAAACCGGAGG

AAGGUGGGGA

UGA

CGUC

AAAUC

AUC

A

UGCCCC U

UA

UGACCUGGGCU

AC

ACACGUGCUAC A A U

GG

CU

GG

UAC

A A C GA

GUC G

CG

A GUC

GG U

GA

CG

GC

AAG

CU

AAU

CU

CU

UAAAG

CC

AG

UCUCA

GU

UCGGAUUGUAGGC

UGC

AACUCGCCUACAU

GAAGU

CG

GAAUCGC

UAGUAAUCGCGGA U

CA

GCACG

CC

GC

GG

UGA

AU

ACGU

UCC

CGGGCCUUGUA

CACACCGCCCG

UC

ACACCACGA

GAGUUUGUAACACC

CGAA

GUCGGU

GAGGUA

A CCU

U UUGG

AGCCA

GCCGCCUAA

GGUGGGAUAGAUGA

UUGGGGUGA

AGU

CGU

AAC

AA

G

U A G C C G U A U C GGA

AGNNNNNNNNNNNNNNNNNNNNNN

0.3

L. delbrueckii (acidophilus)

L. salivariusL. reuteri

L. sakei

L. plantarum

L. buchneri

L. c

asei

Host:

Corbiculate apidMycocepurus smithiiSolenopsis halictid

F i g . S1. 16S rDNA maximum-likelihood tree of the genus Lactobacillus, based on partial sequences. Branch widths are proportional to bootstrap support from 100 pseudoreplicates. Highlighted edges represent Hymenoptera-associated lactobacilli as indicated in the legend. Major clades are indicated with curved lines and named according to previous studies (54-57).

0.00.100.200.300.400.500.600.700.800.901.01.10

Carnobacterium_divergens_NR_044706_280Carnobacterium_maltaromaticum_NR_044710_281

0.720.720.720.720.72

Abiotrophia_defectiva_ATCC_49176_NR_025863_284Eremococcus_coleocola_NR_026481_287

1.001.001.001.001.000.970.970.970.970.97

Listeria_rocourtiae_FJ557241_056Bacillus_thuringiensis_str._Al_Hakam_CP000485_ag_069

Bacillus_coagulans_AF466695_2780.970.970.970.970.970.990.990.990.990.99

Enterococcus_moraviensis_NR_028794_279Enterococcus_hirae_NR_037082_272AY735408_Enterococcus_faecium_002Enterococcus_faecium_EF533987_092

1.001.001.001.001.000.970.970.970.970.970.990.990.990.990.99

Streptococcus_parasanguinis_ATCC_15912_NR_024842_275Lactococcus_lactis_subsp._lactis_KF147_NC_013656_BF_266Lactococcus_lactis_subsp._lactis_KF147_NC_013656_T_267Lactococcus_lactis_subsp._lactis_KF147_NC_013656_BQ_268Lactococcus_lactis_subsp._lactis_KF147_NC_013656_CB_269Lactococcus_lactis_subsp._lactis_KF147_NC_013656_CH_270Lactococcus_lactis_subsp._lactis_KF147_NC_013656_BM_271

1.001.001.001.001.001.001.001.001.001.00

0.680.680.680.680.68

0.680.680.680.680.68

0.400.400.400.400.40

Weissella_kandleri_NR_044659_274Bacteria_G2WUYFR02DPIHT_Solenopsis_590

0.640.640.640.640.64

M58809_Lactobacillus_bifermentans_025Lactobacillus_bifermentans_JN175330_205

Bacteria_G2WUYFR02DS0HK_Solenopsis_5551.001.001.001.001.00

Lactobacillus_backi_DQ406862_122M58813_Lactobacillus_coryniformis_026uncultured_bacterium_GQ479965_192

1.001.001.001.001.00

Lactobacillus_rennini_LSP576007_046Lactobacillus_halophilus_AB240455_081

1.001.001.001.001.000.790.790.790.790.79

0.800.800.800.800.800.990.990.990.990.99

Paralactobacillus_selangorensis_NR_024885_282Lactobacillus_algidus_AB033209_277Lactobacillus_satsumensis_AB362683_166Lactobacillus_oeni_EU821345_180

0.930.930.930.930.93

Lactobacillus_cacaonum_AM905389_079M58824_Lactobacillus_mali_029

Lactobacillus_hordei_EU074850_147Lactobacillus_mali_FJ157230_225

0.960.960.960.960.960.640.640.640.640.640.960.960.960.960.96

Lactobacillus_capillatus_AB365978_052Lactobacillus_sucicola_AB458681_087

0.570.570.570.570.57

Lactobacillus_uvarum_EU345000_075Lactobacillus_sp._IMCC1736_DQ664203_078

0.680.680.680.680.680.880.880.880.880.88

0.630.630.630.630.63

0.260.260.260.260.26

Lactobacillus_nagelii_AB162131_073Lactobacillus_ghanensis_DQ523489_133

1.001.001.001.001.00

Lactobacillus_mobilis_AB242320_188uncultured_Lactobacillus_sp._HM218831_198

uncultured_Lactobacillus_sp._HM218848_097uncultured_Lactobacillus_sp._HM218858_445

1.001.001.001.001.001.001.001.001.001.000.860.860.860.860.86

0.900.900.900.900.90

M58807_Lactobacillus_animalis_024Lactobacillus_apodemi_AJ871178_070uncultured_bacterium_DQ075206_041Lactobacillus_murinus_AJ621554_134

uncultured_bacterium_DQ815470_203uncultured_bacterium_DQ815437_216

0.930.930.930.930.93

uncultured_bacterium_EU791129_449uncultured_bacterium_EU790976_453

0.820.820.820.820.82

Lactobacillus_Q2_F7SSZP003G8XXC_330uncultured_bacterium_EU791098_446

0.810.810.810.810.81

Lactobacillus_Q9_F7SSZP003GEOFA_358Lactobacillus_Q1_F7SSZP003G0JMG_353Lactobacillus_Q1_F7SSZP003FIY29_362

1.001.001.001.001.000.810.810.810.810.810.310.310.310.310.31

0.470.470.470.470.47

0.800.800.800.800.80

0.950.950.950.950.95

Lactobacillus_equi_AB425924_190Bacteria_G4RPUYA02C9XKQ_Mycocepurus_476

M58803_Lactobacillus_agilis_021uncultured_bacterium_AB559729_186

0.650.650.650.650.650.810.810.810.810.811.001.001.001.001.00

Lactobacillus_sp._C33LV5_AF197125_262uncultured_bacterium_AB506300_187M58828_Lactobacillus_ruminis_030Lactobacillus_ruminis_AB326354_112

0.590.590.590.590.591.001.001.001.001.000.950.950.950.950.95

0.360.360.360.360.36

Lactobacillus_ceti_AM292799_150Lactobacillus_saerimneri_AY255802_227Lactobacillus_sp._MbBipro17_HM534774_325Lactobacillus_sp._Tporo2_HM534775_324Lactobacillus_pobuzihii_AB326365_111Lactobacillus_sp._MbBbr1_HM534771_321

Lactobacillus_sp._121B_AF305930_261Lactobacillus_acidipiscis_AB023836_617

0.630.630.630.630.630.450.450.450.450.450.800.800.800.800.80

0.650.650.650.650.651.001.001.001.001.00

Lactobacillus_hayakitensis_AB267406_118uncultured_bacterium_AY212750_418

1.001.001.001.001.00

Bacteria_G4RPUYA02EQEGE_Mycocepurus_494Lactobacillus_salivarius_AB186340_107Lactobacillus_salivarius_EU428010_141

Bacteria_G4RPUYA02DHK61_Mycocepurus_477uncultured_Lactobacillus_sp._AY672088_235Bacteria_G4RPUYA02DJDFD_Mycocepurus_489Bacteria_G4RPUYA02EYMBR_Mycocepurus_540

Bacteria_G2WUYFR01BYHUN_Solenopsis_557Bacteria_G4RPUYA02D1FDL_Mycocepurus_483

Bacteria_G4SXT0Z01B916P_Solenopsis_5650.330.330.330.330.330.720.720.720.720.72

0.240.240.240.240.24

0.190.190.190.190.190.710.710.710.710.71

0.590.590.590.590.59

Bacteria_G4RPUYA02DQ24F_Mycocepurus_487uncultured_bacterium_GU293196_197

Lactobacillus_intermedius_AB167386_090Bacteria_G2WUYFR02DBVUH_Solenopsis_606

0.510.510.510.510.510.230.230.230.230.23

Bacteria_G2WUYFR01AL9EQ_Solenopsis_576Lactobacillus_GeEuTuBc0029_G1OJGBH03GOLAZ_376Lactobacillus_aviarius_AB001837_276Bacteria_G4RPUYA02EBAXL_Mycocepurus_538

0.630.630.630.630.63

Bacteria_G4RPUYA02EALIM_Mycocepurus_479Bacteria_G4RPUYA02EECR6_Mycocepurus_478

Bacteria_G4RPUYA02DLZY4_Mycocepurus_542Bacteria_G4RPUYA02ECJZU_Mycocepurus_504Bacteria_G4RPUYA02DSRND_Mycocepurus_481

Bacteria_G4RPUYA02EHKZP_Mycocepurus_4820.460.460.460.460.46

Bacteria_G4RPUYA02EKHNN_Mycocepurus_490Bacteria_G4RPUYA02DOSON_Mycocepurus_485

Bacteria_G4RPUYA02C1C45_Mycocepurus_5230.240.240.240.240.240.100.100.100.100.100.140.140.140.140.14

Bacteria_G4RPUYA02DCJC6_Mycocepurus_501Bacteria_G4RPUYA02EGVOD_Mycocepurus_539

0.700.700.700.700.70

Bacteria_G4RPUYA02EDTH9_Mycocepurus_493Bacteria_G4RPUYA02D8Y4Y_Mycocepurus_499

Bacteria_G4RPUYA02DJDR6_Mycocepurus_5160.500.500.500.500.500.260.260.260.260.26

0.900.900.900.900.90

0.100.100.100.100.10

0.240.240.240.240.24

0.310.310.310.310.310.310.310.310.310.310.200.200.200.200.200.500.500.500.500.50

0.290.290.290.290.290.500.500.500.500.50

0.070.070.070.070.07

0.130.130.130.130.13

0.230.230.230.230.23

0.350.350.350.350.35

0.250.250.250.250.25

0.540.540.540.540.54

0.420.420.420.420.42

0.610.610.610.610.61

0.540.540.540.540.54

0.030.030.030.030.03

0.060.060.060.060.06

0.350.350.350.350.35

0.750.750.750.750.75

0.00.100.200.300.400.500.600.700.800.901.01.101.201.301.401.50

Carnobacterium_divergens_NR_044706_280Carnobacterium_maltaromaticum_NR_044710_281

0.720.720.720.720.72

Abiotrophia_defectiva_ATCC_49176_NR_025863_284Eremococcus_coleocola_NR_026481_287

1.001.001.001.001.000.970.970.970.970.97

Listeria_rocourtiae_FJ557241_056Bacillus_thuringiensis_str._Al_Hakam_CP000485_ag_069

Bacillus_coagulans_AF466695_2780.970.970.970.970.970.990.990.990.990.99

Enterococcus_moraviensis_NR_028794_279Enterococcus_hirae_NR_037082_272AY735408_Enterococcus_faecium_002Enterococcus_faecium_EF533987_092

1.001.001.001.001.000.970.970.970.970.970.990.990.990.990.99

Streptococcus_parasanguinis_ATCC_15912_NR_024842_275Lactococcus_lactis_subsp._lactis_KF147_NC_013656_BF_266Lactococcus_lactis_subsp._lactis_KF147_NC_013656_T_267Lactococcus_lactis_subsp._lactis_KF147_NC_013656_BQ_268Lactococcus_lactis_subsp._lactis_KF147_NC_013656_CB_269Lactococcus_lactis_subsp._lactis_KF147_NC_013656_CH_270Lactococcus_lactis_subsp._lactis_KF147_NC_013656_BM_271

1.001.001.001.001.001.001.001.001.001.00

0.680.680.680.680.68

0.680.680.680.680.68

0.400.400.400.400.40

Weissella_kandleri_NR_044659_274Bacteria_G2WUYFR02DPIHT_Solenopsis_590

0.640.640.640.640.64

M58809_Lactobacillus_bifermentans_025Lactobacillus_bifermentans_JN175330_205

Bacteria_G2WUYFR02DS0HK_Solenopsis_5551.001.001.001.001.00

Lactobacillus_backi_DQ406862_122M58813_Lactobacillus_coryniformis_026uncultured_bacterium_GQ479965_192

1.001.001.001.001.00

Lactobacillus_rennini_LSP576007_046Lactobacillus_halophilus_AB240455_081

1.001.001.001.001.000.790.790.790.790.79

0.800.800.800.800.800.990.990.990.990.99

Paralactobacillus_selangorensis_NR_024885_282Lactobacillus_algidus_AB033209_277Lactobacillus_satsumensis_AB362683_166Lactobacillus_oeni_EU821345_180

0.930.930.930.930.93

Lactobacillus_cacaonum_AM905389_079M58824_Lactobacillus_mali_029

Lactobacillus_hordei_EU074850_147Lactobacillus_mali_FJ157230_225

0.960.960.960.960.960.640.640.640.640.640.960.960.960.960.96

Lactobacillus_capillatus_AB365978_052Lactobacillus_sucicola_AB458681_087

0.570.570.570.570.57

Lactobacillus_uvarum_EU345000_075Lactobacillus_sp._IMCC1736_DQ664203_078

0.680.680.680.680.680.880.880.880.880.88

0.630.630.630.630.63

0.260.260.260.260.26

Lactobacillus_nagelii_AB162131_073Lactobacillus_ghanensis_DQ523489_133

1.001.001.001.001.00

Lactobacillus_mobilis_AB242320_188uncultured_Lactobacillus_sp._HM218831_198

uncultured_Lactobacillus_sp._HM218848_097uncultured_Lactobacillus_sp._HM218858_445

1.001.001.001.001.001.001.001.001. 001.000.860.860.860.860.86

0.900.900.900.900.90

M58807_Lactobacillus_animalis_024Lactobacillus_apodemi_AJ871178_070uncultured_bacterium_DQ075206_041Lactobacillus_murinus_AJ621554_134

uncultured_bacterium_DQ815470_203uncultured_bacterium_DQ815437_216

0.930.930.930.930.93

uncultured_bacterium_EU791129_449uncultured_bacterium_EU790976_453

0.820.820.820.820.82

Lactobacillus_Q2_F7SSZP003G8XXC_330uncultured_bacterium_EU791098_446

0.810.810.810.810.81

Lactobacillus_Q9_F7SSZP003GEOFA_358Lactobacillus_Q1_F7SSZP003G0JMG_353Lactobacillus_Q1_F7SSZP003FIY29_362

1.001.001.001.001.000.810.810.810.810.810.310.310.310.310.31

0.470.470.470.470.47

0.800.800.800.800.80

0.950.950.950.950.95

Lactobacillus_equi_AB425924_190Bacteria_G4RPUYA02C9XKQ_Mycocepurus_476

M58803_Lactobacillus_agilis_021uncultured_bacterium_AB559729_186

0.650.650.650.650.650.810.810.810.810.811.001.001.001.001.00

Lactobacillus_sp._C33LV5_AF197125_262uncultured_bacterium_AB506300_187M58828_Lactobacillus_ruminis_030Lactobacillus_ruminis_AB326354_112

0.590.590.590.590.591.001.001.001.001.000.950.950.950.950.95

0.360.360.360.360.36

Lactobacillus_ceti_AM292799_150Lactobacillus_saerimneri_AY255802_227Lactobacillus_sp._MbBipro17_HM534774_325Lactobacillus_sp._Tporo2_HM534775_324Lactobacillus_pobuzihii_AB326365_111Lactobacillus_sp._MbBbr1_HM534771_321

Lactobacillus_sp._121B_AF305930_261Lactobacillus_acidipiscis_AB023836_617

0.630.630.630.630.630.450.450.450.450.450.800.800.800.800.80

0.650.650.650.650.651.001.001.001.001.00

Lactobacillus_hayakitensis_AB267406_118uncultured_bacterium_AY212750_418

1.001.001.001.001.00

Bacteria_G4RPUYA02EQEGE_Mycocepurus_494Lactobacillus_salivarius_AB186340_107Lactobacillus_salivarius_EU428010_141

Bacteria_G4RPUYA02DHK61_Mycocepurus_477uncultured_Lactobacillus_sp._AY672088_235Bacteria_G4RPUYA02DJDFD_Mycocepurus_489Bacteria_G4RPUYA02EYMBR_Mycocepurus_540

Bacteria_G2WUYFR01BYHUN_Solenopsis_557Bacteria_G4RPUYA02D1FDL_Mycocepurus_483

Bacteria_G4SXT0Z01B916P_Solenopsis_5650.330.330.330.330.330.720.720.720.720.72

0.240.240.240.240.24

0.190.190.190.190.190.710.710.710.710.71

0.590.590.590.590.59

Bacteria_G4RPUYA02DQ24F_Mycocepurus_487uncultured_bacterium_GU293196_197

Lactobacillus_intermedius_AB167386_090Bacteria_G2WUYFR02DBVUH_Solenopsis_606

0. 510.510.510.510.510.230.230.230.230.23

Bacteria_G2WUYFR01AL9EQ_Solenopsis_576Lactobacillus_GeEuTuBc0029_G1OJGBH03GOLAZ_376Lactobacillus_aviarius_AB001837_276Bacteria_G4RPUYA02EBAXL_Mycocepurus_538

0.630.630.630.630.63

Bacteria_G4RPUYA02EALIM_Mycocepurus_479Bacteria_G4RPUYA02EECR6_Mycocepurus_478

Bacteria_G4RPUYA02DLZY4_Mycocepurus_542Bacteria_G4RPUYA02ECJZU_Mycocepurus_504Bacteria_G4RPUYA02DSRND_Mycocepurus_481

Bacteria_G4RPUYA02EHKZP_Mycocepurus_4820.460.460.460.460.46

Bacteria_G4RPUYA02EKHNN_Mycocepurus_490Bacteria_G4RPUYA02DOSON_Mycocepurus_485

Bacteria_G4RPUYA02C1C45_Mycocepurus_5230.240.240.240.240.240.100.100.100.100.100.140.140.140.140.14

Bacteria_G4RPUYA02DCJC6_Mycocepurus_501Bacteria_G4RPUYA02EGVOD_Mycocepurus_539

0.700.700.700.700.70

Bacteria_G4RPUYA02EDTH9_Mycocepurus_493Bacteria_G4RPUYA02D8Y4Y_Mycocepurus_499

Bacteria_G4RPUYA02DJDR6_Mycocepurus_5160.500.500.500.500.500.260.260.260.260.26

0.900.900.900.900.90

0.100.100.100.100.10

0.240.240.240.240.24

0.310.310.310.310.310.3 10.310.310.310.310.200.200.200.200.200.500.500.500.500.50

0.290.290.290.290.290.500.500.500.500.50

0.070.070.070.070.07

0.130.130.130.130.13

0.230.230.230.230.23

0.350.350.350.350.35

0.250.250.250.250.25

0.540.540.540.540.54

0.420.420.420.420.42

0.610.610.610.610.61

0.540.540.540.540.54

Lactobacillus_concavus_AY683322_076uncultured_bacterium_AM930364_456

1.001.001.001.001.00

Lactobacillus_dextrinicus_D87679_131uncultured_bacterium_AM500777_455

1.001.001.001.001.001.001.001.001.001.00

Lactobacillus_composti_AB268119_058Lactobacillus_perolens_Y19167_260

Lactobacillus_harbinensis_AB368915_129Lactobacillus_brevis_AY974809_168

0.990.990.990.990.991.001.0 01.001.001.000.450.450.450.450.45

Lactobacillus_floricola_AB523781_173Lactobacillus_sp._MbBipro19_HM534770_312

1.001.001.001.001.00

Lactobacillus_tucceti_LSP576006_181Lactobacillus_nodensis_AB332024_415

0.890.890.890.890.89

Lactobacillus_letivazi_AJ417738_257Lactobacillus_versmoldensis_AJ496791_256

uncultured_bacterium_AF371492_223Lactobacillus_nantensis_AY690834_627Lactobacillus_crustorum_FJ645924_184Lactobacillus_farciminis_AJ417499_254Lactobacillus_mindensis_LSP313530_050

M58804_Lactobacillus_alimentarius_022Lactobacillus_bobalius_AY681134_080

Lactobacillus_kimchii_AF183558_6150.500.500.500.500.500.960.960.960.960.96

0.550.550.550.550.550.330.330.330.330.330.960.960.960.960.96

1.001.001.001.001.000.290.290.290.290.29

0.380.380.380.380.380.260.260.260.260.26

0.740.740.740.740.74

Lactobacillus_sp._Thmro15_HM534814_319uncultured_Lactobacillus_sp._HM113222_148

uncultured_Lactobacillus_sp._HM046576_088uncultured_Firmicutes_bacterium_DQ837632_286Lactobacillus_sp._F7_EU753690_289

0.820.820.820.820.821.001.001.001.001.000.720.720.720.720.72

0.540.540.540.540.54

Lactobacillus_sp._Adhmto19_HM534810_323uncultured_Lactobacillus_sp._HM112055_149

uncultured_Lactobacillus_sp._HM113158_2260.240.240.240.240.240.640.640.640.640.64

uncultured_Firmicutes_bacterium_HM215043_121uncultured_Firmicutes_bacterium_HM215041_119uncultured_Firmicutes_bacterium_HM215042_120

0.970.970.970.970.971.001.001.001.001.00

uncultured_Bacilli_bacterium_HM113258_155uncultured_Firmicutes_bacterium_DQ837631_473uncultured_Firmicutes_bacterium_DQ837630_474

1.001.001.001.001.000.860.860.860.860.861.001.001.001.001.00

0.240.240.240.240.24

0.450.450.450.450.45

Lactobacillus_amylotrophicus_AM236149_114M58806_Lactobacillus_amylophilus_023uncultured_bacterium_AM500848_457

0.960.960.960.960.961.001.001.001.001.00

Bacteria_G2WUYFR01ALAWT_Solenopsis_575Bacteria_G2WUYFR02DXBGU_Solenopsis_561

Lactobacillus_sp._TS3_AB284946_102Bacteria_G2WUYFR01BMLOS_Solenopsis_568

Bacteria_G2WUYFR01AWLV8_Solenopsis_567Bacteria_G2WUYFR02EUU2R_Solenopsis_592

0.650.650.650.650.65

Bacteria_G2WUYFR02D8NSR_Solenopsis_588Bacteria_G2WUYFR01AY213_Solenopsis_609

0.810.810.810.810.81

Bacteria_G2WUYFR02D6JYS_Solenopsis_586Bacteria_G2WUYFR01B9IUO_Solenopsis_602

0.380.380.380.380.38

Bacteria_G2WUYFR02DYQIU_Solenopsis_591Bacteria_G2WUYFR01CEH5G_Solenopsis_599

0.750.750.750.750.750.380.380.380.380.38

0.280.280.280.280.28

0.340.340.340.340.340.210.210.210.210.21

0.330.330.330.330.330.750.750.750.750.75

0.050.050.050.050.05

0.040.040.040.040.04

0.000.000.000.000.00

Lactobacillus_fuchuensis_AB370875_109Lactobacillus_graminis_AM113778_045Bacteria_G28NS4E02EPXZY_Solenopsis_583Lactobacillus_curvatus_AM113777_621

0.340.340.340.340.34

Lactobacillus_sakei_EU555174_224uncultured_bacterium_DQ922980_431

0.810.810.810.810.81

Bacteria_G2WUYFR01BCWHI_Solenopsis_580Bacteria_G2WUYFR01BEKHY_Solenopsis_562Bacteria_G2WUYFR01BNE8X_Solenopsis_596

0.360.360.360.360.36

Bacteria_G2WUYFR01BQJEU_Solenopsis_569Bacteria_G2WUYFR01B93S1_Solenopsis_597

0.200.200.200.200.200.510.510.510.510.510.140.140.140.140.14

0.170.170.170.170.170.500.500.500.500.50

0.860.860.860.860.86

Lactobacillus_thailandensis_AB257863_060Lactobacillus_pantheris_AB362679_172

0.990.990.990.990.99

uncultured_compost_bacterium_FN667294_204uncultured_bacterium_AF371503_244

M58831_Lactobacillus_sharpeae_033Bacteria_G2WUYFR02D4CBL_Solenopsis_581

0.990.990.990.990.99

Lactobacillus_guizhouensis_GU138576_113Lactobacillus_guizhouensis_EF433578_124

0.500.500.500.500.500.960.960.960.960.96

0.910 .910.910.910.910.340.340.340.340.34

0.740.740.740.740.74

Lactobacillus_camelliae_AB257864_074uncultured_bacterium_GQ477902_196

uncultured_bacterium_GQ477899_2400.780.780.780.780.780.970.970.970.970.97

Bacteria_G2WUYFR02D1R7T_Solenopsis_560uncultured_compost_bacterium_FN667075_209Lactobacillus_nasuensis_AB608051_412

1.001.001.001.001.000.300.300.300.300.30

Lactobacillus_manihotivorans_AF000163_259Bacteria_G2WUYFR02D23R9_Solenopsis_570

uncultured_compost_bacterium_FN667077_210Bacteria_G2WUYFR02DXNIT_Solenopsis_604

0.780.780.780.780.780.350.350.350.350.350.600.600.600.600.60

0.720.720.720.720.72

0.380.380.380.380.38

Lactobacillus_saniviri_AB602569_307Lactobacillus_sp._Akpobro1_HM534767_314

1.001.001.001.001.00

Lactobacillus_sp._LM_17_AJ132757_417Lactobacillus_rhamnosus_EU184020_170

Lactobacillus_sp._N3_1_1_AB379909_2490.850.850.850.850.850.260.260.260.260.2 6

Lactobacillus_zeae_D86516_613X61135_Lactobacillus_casei_039M23928_Lactobacillus_casei_040Bacteria_G4RPUYA02DO5UR_Mycocepurus_498Bacteria_G4RPUYA02DGY9G_Mycocepurus_503

Bacteria_G4RPUYA02C44TI_Mycocepurus_553

0.850.850.850.850.850.800.800.800.800.80

0.460.460.460.460.46

Lactobacillus_larvae_AY667700_464Lactobacillus_GeEuF1Bc0029_G1OJGBH03GBVJ2_383

Lactobacillus_GeEuL2Bc0029_G1OJGBH03FPFCW_399Lactobacillus_paracasei_AY773954_215

Lactobacillus_sp._N1_5_2_AB379908_2510.360.360.360.360.36

Lactobacillus_sp._N4_4_AB379912_452Bacteria_G2WUYFR02D35PT_Solenopsis_566

0.390.390.390.390.39

Lactobacillus_GeEuF1Bc0029_G1OJGBH03G7UHR_377Lactobacillus_GeEuF1Bc0029_G1OJGBH03HE4SG_381Lactobacillus_GeEuF1Bc0029_G1OJGBH03GD18U_386Lactobacillus_GeEuF1Bc0029_G1OJGBH03FXRZZ_396Lactobacillus_GeEuF1Bc0029_G1OJGBH03HA4AJ_401

0.680.680.680.680.680.300.300.300.300.300.130.130.130.130.13

0.130.130.130.130.13

0.190.190.190.190.19

0.060.060.060.060.06

0.500.500.500.500.50

0.300.300.300.300.30

0.260.260.260.260.26

Pediococcus_pentosaceus_AB362987_053Bacteria_G2WUYFR02EYU2C_Solenopsis_608

0.530.530.530.530.53

uncultured_compost_bacterium_FN667076_208uncultured_bacterium_AF371496_213

0.780.780.780.780.78

Lactobacillus_senmaizukei_AB297927_414Lactobacillus_hammesii_AJ632219_043Lactobacillus_parabrevis_AM158249_095

Lactobacillus_sp._1.1424_FN185731_099uncultured_compost_bacterium_FN667298_211

0.590.590.590.590.590.590.590.590.590.590.090.090.090.090.090.360.360.360.360.36

Lactobacillus_brevis_ATCC_367_CP000416_f_177Bacteria_G2WUYFR02C9Q6O_Solenopsis_578

M58810_Lactobacillus_brevis_014X61134_Lactobacillus_brevis_013Bacteria_G2WUYFR01BA4B4_Solenopsis_564

0.410.410.410.410.41

Lactobacillus_brevis_ATCC_367_CP000416_o_176Lactobacillus_brevis_ATCC_367_CP000416_l_179Lactobacillus_brevis_ATCC_367_CP000416_c_174Lactobacillus_brevis_ATCC_367_CP000416_175

0.240.240.240.240.240.400.400.400.400.40

Bacteria_G2WUYFR02EUR0O_Solenopsis_574Bacteria_G2WUYFR01CAH48_Solenopsis_603

0.970.970.970.970.97

Lactobacillus_spicheri_LSP534844_059Lactobacillus_namurensis_AM259118_096

Lactobacillus_acidifarinae_AJ632158_093Lactobacillus_zymae_AJ632157_094

0.990.990 .990.990.990.910.910.910.910.910.700.700.700.700.70

0.470.470.470.470.47

0.280.280.280.280.28

0.470.470.470.470.47

0.420.420.420.420.42

0.340.340.340.340.34

Lactobacillus_senioris_AB602570_298Lactobacillus_sp._Akporo7_HM534765_311

1.001.001.001.001.00

Lactobacillus_sp._JKD6_AF264701_614Lactobacillus_parafarraginis_AB262734_622

Lactobacillus_sp._r2_GQ247886_123M58821_Lactobacillus_hilgardii_017M59295_Lactobacillus_sp._034

0.440.440.440.440.440.950.950.950.950.95

Lactobacillus_farraginis_HM534766_139Lactobacillus_farraginis_AB262732_183Lactobacillus_faeni_AB362687_428

0.600.600.600.600.601.001.001.001.001.000.780.780.780.780.78

0.600.600.600.600.600.250.250.250.250.25

Lactobacillus_sp._NGRI_0130_AB362984_250Lactobacillus_rapi_AB366389_624

0.950.950.950.950.95

Lactobacillus_kisonensis_AB366388_628Lactobacillus_sp._rennanqilfy19_AY363377_237Lactobacillus_parabuchneri_AB205056_626

0.570.570.570.570.57

Lactobacillus_fermentum_FJ844993_130Lactobacillus_kefiri_AJ621553_135

1.001.001.001.001.00

Lactobacillus_otakiensis_AB366386_620Lactobacillus_sunkii_AB366385_625M58811_Lactobacillus_buchneri_015Lactobacillus_parakefiri_AY026750_612

0.860.860.860.860.860.400.400.400.400.400.380.380.380.380.380.640.640.640.640.640.840.840.840.840.840.510.510.510.510.510.510.510.510.510.51

0.820.820.820.820.82

0.890.890.890.890.89

Lactobacillus_ozensis_AB572588_051Lactobacillus_sp._MbBipro7_HM534743_313

0.960.960.960.960.96

uncultured_Bacilli_bacterium_HM112474_145uncultured_Lactobacillus_sp._HM008721_068

Lactobacillus_sp._Am_09_AJ971903_295Lactobacillus_kunkeei_AB559820_185Lactobacillus_kunkeei_EU753691_291

0.990.990.990.990.990.550.550.550.550.550.960.960.960.960.960.550.550.550.550.55

uncultured_Bacilli_bacterium_HM109480_143uncultured_Bacilli_bacterium_HM109610_144uncultured_Bacilli_bacterium_HM112778_146

0.990.990.990.990.99

uncultured_Bacilli_bacterium_HM112623_467Lactobacillus_Q7A_F348WMR04JBQ2M_333Lactobacillus_Q7A_F348WMR04JGOIJ_334

Lactobacillus_Q7A_F348WMR04IFQ7D_360Lactobacillus_Q7A_F348WMR04JDJG4_363

Lactobacillus_Q7A_F348WMR04JKTXT_340Lactobacillus_Q7A_F348WMR04JKJ8J_611

1.001.001.001.001.000.230.230.230.230.230.610.610.610.610.610.230.230.230.230.23

0.240.240.240.240.240.410.410.410.410.41

0.490.490.490.490.49

Lactobacillus_GeEuF1Bc0029_G1OJGBH03GX6IB_397Lactobacillus_GeEuF1Bc0029_G1OJGBH03G5C2A_398Lactobacillus_GeEuF1Bc0029_G1OJGBH03HAYWD_403

0.400.400.400.400.400.970.970.970.970.97

Lactobacillus_GeSoB2Bc0019_G1OJGBH03FWMY4_392Lactobacillus_GeSoB2Bc0019_G1OJGBH03GHBHU_382

Lactobacillus_GeSoB2Bc0019_G1OJGBH03FQASF_390Lactobacillus_GeEuB2Bc0029_G1OJGBH03G4ZG5_389Lactobacillus_GeEuA1Bc0029_G1OJGBH03GHVOY_407Lactobacillus_GeEuPeBc0029_G1OJGBH03FN2ZU_366Lactobacillus_GeEuF1Bc0029_G1OJGBH03GZEIB_379Lactobacillus_GeEuL2Bc0029_G1OJGBH03G5A0S_404Lactobacillus_GeEuB2Bc0029_G1OJGBH03F1OGP_372Lactobacillus_GeEuPeBc0029_G1OJGBH03G6R03_373Lactobacillus_GeEuL2Bc0029_G1OJGBH03F6ICY_393

0.260.260.260.260.26

Lactobacillus_GeSoL1Bc0019_G1OJGBH03GQQ4M_370Lactobacillus_GeEuPeBc0029_G1OJGBH03F3HKE_395

Lactobacillus_GeSoB2Bc0019_G1OJGBH03HCW2S_384Lactobacillus_GeEuB2Bc0029_G1OJGBH03FPP40_408

0.330.330.330.330.33

Lactobacillus_GeEuF1Bc0029_G1OJGBH03FKN70_385Lactobacillus_GeEuF1Bc0029_G1OJGBH03F5LSE_409

Lactobacillus_GeEuF1Bc0029_G1OJGBH03G4BBA_394Lactobacillus_GeEuF1Bc0029_G1OJGBH03GL6DL_400

0.400.400.400.400.400.550.550.550.550.550.310.310.310.310.31

0.070.070.070.070.07

0.010.010.010.010.010.040.040.040.040.040.030.030.030.030.03

0.100.100.100.100.10

0.390.390.390.390.39

0.130.130.130.130.130.160.160.160.160.16

0.330.330.330.330.33

0.360.360.360.360.36

0.360.360.360.360.36

Lactobacillus_sp._MbBipto3_HM534760_308Lactobacillus_sp._Mbhoto3_HM534763_310

1.001.001.001.001.00

X76330|g535112_Lactobacillus_fructivorans_028Lactobacillus_homohiochii_AJ621552_128

0.960.960.960.960.96

Lactobacillus_sp._Akhmbto4_HM534764_306Lactobacillus_florum_AB498047_048Lactobacillus_florum_AB498046_103

1.0 01.001.001.001.00

Lactobacillus_lindneri_X95421_252X61132_Lactobacillus_sanfrancisco_031X76327|g535106_Lactobacillus_sanfrancisco_032

1.001.001.001.001.000.860.860.860.860.860.820.820.820.820.82

1.001.001.001.001.000.930.930.930.930.93

Lactobacillus_Q13_F7SSZP003FI5FN_326Lactobacillus_Q13_F7SSZP003HFPEY_331Lactobacillus_Q13_F7SSZP003G5ZTS_349

Lactobacillus_Q1_F7SSZP003G3NEK_3520.790.790.790.790.790.190.190.190.190.19

0.230.230.230.230.23

Lactobacillus_Q1_F7SSZP003GUV9L_378Lactobacillus_Q11_F7SSZP003GTXXJ_354Lactobacillus_Q1_F7SSZP003GSQA4_329

Lactobacillus_Q1_F7SSZP003GRNEB_339Lactobacillus_Q1_F7SSZP003F337Q_327Lactobacillus_Q1_F7SSZP003HB7B3_332

0.560.560.560.560.560.360.360.360.360.36

Lactobacillus_Q11_F7SSZP003HHA6K_338Lactobacillus_Q1_F7SSZP003HBKSR_328

Lactobacillus_Q1_F7SSZP003HHGTB_3350.400.400.400.400.400.130.130.130.130.13

0.400.400.400.400.400.820.820.820.820.82

0.900.900.900.900.90

Lactobacillus_Q13_F7SSZP003FP9MZ_359Lactobacillus_Q1_F7SSZP003GZRYO_348

Lactobacillus_Q13_F7SSZP003GTPZN_375Lactobacillus_Q13_F7SSZP003FK90P_365Lactobacillus_Q1_F7SSZP003GVG3B_367

0.280.280.280.280.28

Lactobacillus_Q13_F7SSZP003FNTFE_361Lactobacillus_Q1_F7SSZP003G9G18_364

Lactobacillus_Q1_F7SSZP003FO813_3740.530.530.530.530.530.050.050.050.050.050.070.070.070.070.07

Lactobacillus_Q1_F7SSZP003F6H96_369Lactobacillus_Q13_F7SSZP003GLX8O_347

Lactobacillus_Q1_F7SSZP003HB207_344Lactobacillus_Q13_F7SSZP003GSJYU_350Lactobacillus_Q1_F7SSZP003G83HT_355Lactobacillus_Q1_F7SSZP003FQFVI_368

0.930.930.930.930.930.820.820.820.820.82

Lactobacillus_Q1_F7SSZP003FVDOE_343Lactobacillus_Q1_F7SSZP003GB27S_351

Lactobacillus_Q1_F7SSZP003FZBLV_345Lactobacillus_Q13_F7SSZP003HAPYQ_346

Lactobacillus_Q1_F7SSZP003FZDPQ_356Lactobacillus_Q1_F7SSZP003FJ41T_341

Lactobacillus_Q1_F7SSZP003FKU5E_3570.460.460.460.460.46

Lactobacillus_Q1_F7SSZP003FV2DK_342Lactobacillus_Q13_F7SSZP003GM303_371

0.130.130.130.130.130.030.030.030.030.03

0.010.010.010.010.010.090.090.090.090.09

0.030.030.030.030.030.000.000.000.000.000.050.050.050.050.05

0.060.060.060.060.060.070.070.070.0 70.07

0.070.070.070.070.070.050.050.050.050.05

0.040.040.040.040.04

0.030.030.030.030.03

0.060.060.060.060.06

0.070.070.070.070.07

0.200.200.200.200.20

0.630.630.630.630.63

0.300.300.300.300.30

0.260.260.260.260.26

0.390.390.390.390.39

0.310.310.310.310.31

0.070.070.070.070.07

0.060.060.060.060.06

Lactobacillus_malefermentans_AM113783_182Bacteria_G2WUYFR02DUYD5_Solenopsis_559

0.990.990.990.990.99

Lactobacillus_sp._DCY51_EU678893_106Bacteria_G2WUYFR02DN04P_Solenopsis_556

Lactobacillus_collinoides_AB005893_044Lactobacillus_paracollinoides_AB159218_167

1.001.001.001.001.00

Lactobacillus_odoratitofui_AB365975_108Lactobacillus_similis_AB282889_077Bacteria_G2WUYFR02ERHIP_Solenopsis_600

0.640.640.640.640.640.460.460.460.460.460.540.540.540.540.54

0.510.510.510.510.510.740.740.740.740.74

0.800.800.800.800.80

uncultured_bacterium_AF371494_220Lactobacillus_GeEuF1Bc0029_G1OJGBH03F8WFB_405

Bacteria_G2WUYFR02DVW1P_Solenopsis_598Bacteria_G28NS4E02DMQ1E_Solenopsis_594

Bacteria_G2WUYFR02D1WHH_Solenopsis_572Bacteria_G2WUYFR02D5DLK_Solenopsis_607

0.880.880.880.880.880.200.200.200.200.20

Lactobacillus_fabifermentans_AM905388_072Lactobacillus_plantarum_FJ915797_245

Bacteria_G28NS4E02EJUZ3_Solenopsis_601Lactobacillus_plantarum_JN126052_160

Lactobacillus_japonicus_AB681817_411Bacteria_G28NS4E02C3G8Q_Solenopsis_577

Bacteria_G28NS4E02DIEI6_Solenopsis_5930.510.510.510.510.51

0.030.030.030.030.03

Lactobacillus_plantarum_AJ965482_127D79211_Lactobacillus_pentosus_018

Lactobacillus_plantarum_AM279758_2020.100.100.100.100.10

M58827_Lactobacillus_plantarum_019Lactobacillus_plantarum_FJ386491_169

0.240.240.240.240.24

Lactobacillus_plantarum_FN252881_447Lactobacillus_plantarum_AB371712_238

Bacteria_G2WUYFR02DYMES_Solenopsis_6100.760.760.760.760.760.300.300.300.300.30

Lactobacillus_plantarum_AB371714_248Bacteria_G4RPUYA02D9F7Z_Mycocepurus_531

Bacteria_G28NS4E02DQD3U_Solenopsis_5580.600.600.600.600.600.130.130.130.130.13

0. 060.060.060.060.06

0.030.030.030.030.03

0.010.010.010.010.01

0.140.140.140.140.14

0.340.340.340.340.34

0.090.090.090.090.09

0.500.500.500.500.50

0.760.760.760.760.76

0.140.140.140.140.14

Lactobacillus_siliginis_AB370882_413Lactobacillus_rossiae_LSP564009_156Lactobacillus_rossiae_AM920328_061Bacteria_G4RPUYA02DO47R_Mycocepurus_541

0.590.590.590.590.59

Lactobacillus_GeEuF1Bc0029_G1OJGBH03GO5Q0_380Lactobacillus_GeEuF1Bc0029_G1OJGBH03HCYM0_388Lactobacillus_GeEuF1Bc0029_G1OJGBH03FYH6Y_406

Lactobacillus_GeEuF1Bc0029_G1OJGBH03G2VUK_391Lactobacillus_GeEuF1Bc0029_G1OJGBH03G2OEC_402

0.850.850.850.850.850.590.590.590.590.590.590.590.590.590.59

0.690.690.690.690.691.001.001.001.001.00

Lactobacillus_suebicus_LSU575744_162Lactobacillus_vaccinostercus_AB362691_419Bacteria_G2WUYFR02DYIH7_Solenopsis_573

1.001.001.001.001.000.970.970.970.970.97

Lactobacillus_oligofermentans_AY733084_110uncultured_bacterium_HQ716645_236

0.530.530.530.530.53

Bacteria_G2WUYFR02EJBF3_Solenopsis_595Bacteria_G4RPUYA02EP6UO_Mycocepurus_488

Bacteria_G4RPUYA02D4F5G_Mycocepurus_5140.910.910.910.910.910.610.610.610.610.61

0.990.990.990.990.99

0.840.840.840.840.84

Lactobacillus_equigenerosi_AB288050_091Lactobacillus_antri_AY253658_157

0.850.850.850.850.85

Lactobacillus_fermentum_AF522394_253Lactobacillus_fermentum_EF535257_234

Bacteria_G2WUYFR01A00YD_Solenopsis_585M58819_Lactobacillus_fermentum_027Lactobacillus_fermentum_GQ131191_132

0.460.460.460.460.460.190.190.190.190.19

1.001.001.001.001.000.750.750.750.750.75

Lactobacillus_sp._G24_AF197126_258Lactobacillus_mucosae_AF126738_616

1.001.001.001.001.00

Lactobacillus_alvi_HQ718585_410Lactobacillus_ingluviei_AF308147_255

Bacteria_G4RPUYA02D2F2O_Mycocepurus_4961.001.001.001.001.000.760.760.760.760.76

Lactobacillus_sp._TMW_1.1309_AM279150_189uncultured_bacterium_AB559717_435Lactobacillus_coleohominis_AM113776_623

1.001.001.001.001.00

Lactobacillus_sp._oral_taxon_052_GQ422710_042X94230|g1313964_Lactobacillus_panis_038

uncultured_bacterium_GQ505032_4540.780.780.780.780.78

uncultured_bacterium_HM218875_432Lactobacillus_kalixensis_AY253659_158X94229|g1313963_Lactobacillus_oris_035uncultured_bacterium_AB559668_434

0.970.970.970.970.970.990.990.990.990.990.530.530.530.530.531.001.001.001.001.00

uncultured_bacterium_AY958911_433X61136_Lactobacillus_vaginalis_036

Lactobacillus_vaginalis_HM534769_138Lactobacillus_vaginalis_AF243177_264Bacteria_G4RPUYA02ENLBJ_Mycocepurus_529

0.240.240.240.240.240.230.230.230.230.230.570.570.570.570.57

Lactobacillus_frumenti_LSP250074_629X76329|g534948_Lactobacillus_pontis_037Bacteria_G4RPUYA02C1IZC_Mycocepurus_534

0.930.930.930.930.93

Lactobacillus_sp._Akhmro1_HM534768_309Lactobacillus_reuteri_F275_AP007281_062Lactobacillus_reuteri_F275_AP007281_c_063Lactobacillus_reuteri_F275_AP007281_n_064Lactobacillus_reuteri_F275_AP007281_f_065Lactobacillus_reuteri_F275_AP007281_q_066Lactobacillus_reuteri_F275_AP007281_i_067

0.880.880.880.880.88

uncultured_bacterium_EU791265_443uncultured_bacterium_EU791072_430Bacteria_G4RPUYA02EQ6U1_Mycocepurus_546

Bacteria_G4RPUYA02DJ8IV_Mycocepurus_533Bacteria_G4RPUYA02D2IM2_Mycocepurus_549

0.590.590.590.590.59

uncultured_bacterium_EU791134_438Bacteria_G4RPUYA02C82F5_Mycocepurus_513

Bacteria_G4RPUYA02C82QY_Mycocepurus_5450.690.690.690.690 .690.510.510.510.510.51

0.050.050.050.050.050.410.410.410.410.41

0.930.930.930.930.93

Bacteria_G4RPUYA02C02W1_Mycocepurus_517Bacteria_G4RPUYA02C8GJU_Mycocepurus_520

Bacteria_G4RPUYA02DBPUF_Mycocepurus_522uncultured_bacterium_GQ175588_243

uncultured_bacterium_EU791181_247uncultured_bacterium_EU791159_440uncultured_bacterium_EU791116_439Bacteria_G4RPUYA02D4ZHO_Mycocepurus_550

0.440.440.440.440.44

AY239419_uncultured_bacterium_012Bacteria_G4RPUYA02DD4H3_Mycocepurus_544Bacteria_G4RPUYA02ECX6B_Mycocepurus_551

uncultured_bacterium_EU622700_459Bacteria_G4RPUYA02DAS3I_Mycocepurus_547

0.420.420.420.420.420.140.140.140.140.140.040.040.040.040.04

0.030.030.030.030.03

Bacteria_G2WUYFR01CFJ17_Solenopsis_579AE017198_Lactobacillus_johnsonii_NCC_533_006AE017198_Lactobacillus_johnsonii_NCC_533_007AE017198_Lactobacillus_johnsonii_NCC_533_008AE017198_Lactobacillus_johnsonii_NCC_533_009AE017198_Lactobacillus_johnsonii_NCC_533_010AE017198_Lactobacillus_johnsonii_NCC_533_011Lactobacillus_johnsonii_EU780913_140Bacteria_G4RPUYA02D066W_Mycocepurus_506Bacteria_G4RPUYA02DN9RG_Mycocepurus_515Bacteria_G4SXT0Z01BWJ7N_Solenopsis_582uncultured_bacterium_EU791127_442

Bacteria_G4RPUYA02DLV9U_Mycocepurus_521Bacteria_G4RPUYA02DCLGW_Mycocepurus_500

Bacteria_G4RPUYA02EL5KB_Mycocepurus_495Bacteria_G4RPUYA02EE9DE_Mycocepurus_527

0.780.780.780.780.780.280.280.280.280.280.110 .110.110.110.11

0.060.060.060.060.06

Bacteria_G4RPUYA02DANKJ_Mycocepurus_519Bacteria_G4RPUYA02D9HKG_Mycocepurus_528Bacteria_G4RPUYA02C93MK_Mycocepurus_554Bacteria_G4RPUYA02C8Q5C_Mycocepurus_525Bacteria_G4RPUYA02DPY4I_Mycocepurus_532

0.540.540.540.540.540.210.210.210.210.210.170.170.170.170.17

Lactobacillus_taiwanensis_EU487512_084Lactobacillus_iatae_EF187258_137

0.410.410.410.410.41

Lactobacillus_gasseri_ATCC_33323_AF519171_618Lactobacillus_sp._61D_FR681902_426AY959035_uncultured_bacterium_004AY958891_uncultured_bacterium_005

uncultured_bacterium_EF653412_219uncultured_bacterium_AY959115_463

uncultured_bacterium_AY959095_241uncultured_bacterium_AY959163_436

uncultured_Firmicutes_bacterium_EF682866_049Lactobacillus_iners_Y16329_057uncultured_bacterium_AY959039_239

Bacteria_G4RPUYA02DE844_Mycocepurus_530Bacteria_G4RPUYA02EQ2ZF_Mycocepurus_537

0.160.160.160.160.160.650.650.650.650.65

0.200.200.200.200.200.360.360.360.360.36

0.400.400.400.400.40

Bacteria_G4RPUYA02D30I7_Mycocepurus_543Lactobacillus_crispatus_AJ242969_265

Bacteria_G4RPUYA02EGYQJ_Mycocepurus_492Bacteria_G4RPUYA02D6ETP_Mycocepurus_491

Bacteria_G4RPUYA02C254J_Mycocepurus_4970.740.740.740.740.74

Lactobacillus_GeEuPeBc0029_G1OJGBH03GSTGE_387Bacteria_G4RPUYA02C1VXY_Mycocepurus_510

Bacteria_G4RPUYA02C8GY8_Mycocepurus_507Bacteria_G4RPUYA02C8R7C_Mycocepurus_536

0.710.710.710.710.71

Bacteria_G4RPUYA02DNU3H_Mycocepurus_512Bacteria_G4RPUYA02D69JH_Mycocepurus_552

0.470.470.470.470.470.170.170.170.170.170.140.140.140.140.140.050.050.050.050.05

Bacteria_G4RPUYA02D481Y_Mycocepurus_524Lactobacillus_crispatus_EU559595_178Bacteria_G4RPUYA02C45QD_Mycocepurus_486Bacteria_G4RPUYA02D8UIL_Mycocepurus_548

0.940.940.940.940.940.130.130.130.130.13

Lactobacillus_crispatus_DQ317604_098Bacteria_G4RPUYA02C41OQ_Mycocepurus_502Bacteria_G4SXT0Z01B38UP_Solenopsis_584

0.960.960.960.960.960.460.460.460.460.46

uncultured_bacterium_AY958844_441Bacteria_G4RPUYA02DQ2EG_Mycocepurus_508

uncultured_bacterium_AY958858_054uncultured_bacterium_AY958900_201

0.880.880.880.880.880.640.640.640.640.64

uncultured_bacterium_DQ057433_465Lactobacillus_gallinarum_LGA417737_047

uncultured_bacterium_GQ267932_217Lactobacillus_acidophilus_EU878007_125Lactobacillus_helveticus_EU419585_221

0.840.840.840.840.840.340.340.340.340.340.090.090.090.090.090.150.150.150.150.15

M58802_Lactobacillus_acidophilus_003uncultured_bacterium_FJ880117_199

0.860.860.860.860.86

Lactobacillus_kitasatonis_AB186339_115Lactobacillus_acidophilus_AY773947_126

Bacteria_G4RPUYA02D8O9Y_Mycocepurus_5090.130.130.130.130.130.230.230.230.230.230.560.560.560.560.56

uncultured_bacterium_GQ267930_218uncultured_bacterium_GQ267866_229

Bacteria_G4RPUYA02DHIVZ_Mycocepurus_505Bacteria_G4RPUYA02DBPK8_Mycocepurus_511

0.510.510.510.510.510.090.090.090.090.09

uncultured_bacterium_DQ318873_421Bacteria_G4RPUYA02D2L56_Mycocepurus_480

0.550.550.550.550.55

Lactobacillaceae_bacterium_DJF_003_EU728746_101uncultured_bacterium_DQ318874_191

0.960.960.960.960.96

Lactobacillus_equicursoris_AB290830_116Lactobacillus_sp._66c_FR681900_427

1.001.001.001.001.00

M58823_Lactobacillus_delbrueckii_016Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_X_301Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_CV_302Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_CY_304Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_B_297Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_CC_299Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_S_305

0.050.050.050.050.05

uncultured_bacterium_GQ267952_214Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_DJ_296Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_CK_300Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_BA_303

0.210.210.210.210.21

0. 140.140.140.140.14

0.410.410.410.410.410.780.780.780.780.78

0.720.720.720.720.72

0.910.910.910.910.91

0.420.420.420.420.42

0.070.070.070.070.07

0.110.110.110.110.11

0.030.030.030.030.03

0.030.030.030.030.03

Lactobacillus_ultunensis_AY253660_159Lactobacillus_kefiranofaciens_subsp._kefiranofaciens_AM113781_630

0.360.360.360.360.36

uncultured_compost_bacterium_FN667084_212uncultured_Lactobacillus_sp._HM218856_458

Bacteria_G4RPUYA02DQODF_Mycocepurus_526Bacteria_G4RPUYA02C1VT3_Mycocepurus_535

0.690.690.690.690.690.350.350.350.350.35

uncultured_Lactobacillus_sp._HM218874_085Bacteria_G4RPUYA02D1G4P_Mycocepurus_518

uncultured_Lactobacillus_sp._HM218864_193uncultured_Lactobacillus_sp._HM218878_451

1.001.001.001.001.000.280.280.280.280.280.230.230.230.230.23

0.070.070.070.070.070.060.060.060.060.06

uncultured_bacterium_FJ682870_232Bacteria_G2WUYFR01AP069_Solenopsis_571

0.570.570.570.570.57

uncultured_Lactobacillus_sp._HM218839_462Bacteria_G4SXT0Z01B6HAY_Solenopsis_563

0.070.070.070.070.07

Lactobacillus_amylovorus_GRL_1112_CP002338_A_161Lactobacillus_amylovorus_GRL_1112_CP002338_K_163Lactobacillus_amylovorus_GRL_1112_CP002338_AQ_164Lactobacillus_amylovorus_GRL_1112_CP002338_BQ_165Bacteria_G4RPUYA02ED17E_Mycocepurus_484uncultured_Lactobacillus_sp._HM218861_246

uncultured_Lactobacillus_sp._HM218863_4200.230.230.230.230.23

uncultured_Lactobacillus_sp._HM218833_460uncultured_Lactobacillus_sp._HM218869_461

0.880.880.880.880.88

uncultured_Lactobacillus_sp._HM218868_448uncultured_Lactobacillus_sp._HM218862_444uncultured_Lactobacillus_sp._HM218873_450

0.410.410.410.410.410.630.630.630.630.63

0.030.030.030.030.03

0.050.050.050.050.05

0.070.070.070.070.07

0.000.000.000.000.00

uncultured_Lactobacillus_sp._HM218837_086uncultured_bacterium_HM218871_194uncultured_bacterium_HM218855_195

0.610.610.610.610.610.570.570.570.570.57

uncultured_bacterium_AY958851_055uncultured_bacterium_AY958918_422

Lactobacillus_psittaci_LPS272391_142Lactobacillus_jensenii_EU559601_171Lactobacillus_fornicalis_Y18654_619

0.960.960.960. 960.960.650.650.650.650.650.410.410.410.410.41

0.660.660.660.660.660.050.050.050.050.05

Lactobacillus_hamsteri_LHA306298_104Lactobacillus_amylolyticus_DSM_11664_Y17361_263

0.660.660.660.660.66

uncultured_bacterium_HM218836_437Lactobacillus_gastricus_AY253657_230

Lactobacillus_intestinalis_LIN306299_100Lactobacillus_sp._ASF360_AF157050_273

uncultured_bacterium_AY239415_206uncultured_bacterium_AY239416_207

0.990.990.990.990.99

Lactobacillus_Q1_F7SSZP003GT0PR_336Lactobacillus_Q13_F7SSZP003GZ6SM_337

0.930.930.930.930.930.760.760.760.760.760.930.930.930.930.93

uncultured_Lactobacillus_sp._HM218872_429uncultured_Lactobacillus_sp._FJ192637_089

uncultured_bacterium_GU808381_200M58801_Lactobacillus_acetotolerans_020Lactobacillus_acetotolerans_FR683099_105

0.990.990.990.990.99

Bacteria_G2WUYFR01BBUKF_Solenopsis_605Lactobacillus_sp._Mbhsr5_HM534808_318Lactobacillus_sp._MbHmro1_HM534806_320

uncultured_Firmicutes_bacterium_HM215048_466Lactobacillus_sp._Adhmro12_HM534786_315Lactobacillus_sp._Afpor8_HM534796_322

0.350.350.350.350.350.050.050.050.050.05

Lactobacillus_sp._Afpoto13_HM534795_316Lactobacillus_sp._Aahonto7_HM534805_317

Firmicutes_bacterium_Bt_aa_02_AJ971929_293Lactobacillus_sp._Mardanium_GU233458_288

Lactobacillus_sp._Taj_KS164_GU233457_2900.990.990.990.990.99

uncultured_Lactobacillus_sp._HM113326_468uncultured_Lactobacillus_sp._HM046568_082uncultured_Lactobacillus_sp._HM046579_083

0.790.790.790.790.79

uncultured_Firmicutes_bacterium_DQ837634_469uncultured_Firmicutes_bacterium_DQ837635_471Bacteria_G2WUYFR01A2OJ0_Solenopsis_589

0.260.260.260.260.260.390.390.390.390.39

0.310.310.310.310.31

uncultured_Lactobacillus_sp._HM113281_154uncultured_Bacilli_bacterium_HM113257_425

0.540.540.540.540.54

uncultured_Lactobacillus_sp._AY370183_071uncultured_Firmicutes_bacterium_DQ837637_472

0.530.530.530.530.53

uncultured_Lactobacillus_sp._HM113333_151uncultured_Lactobacillus_sp._HM112866_153

0.290.290.290.290.29

uncultured_Lactobacillus_sp._HM112010_424Lactobacillus_alvei_AY667698_136Lactobacillus_sp._3b_EU753698_294

0.310.310.310.310.310.440.440.440.440.440.380.380.380.380.38

Lactobacillus_apis_AY667701_222Bacteria_G4SXT0Z01AYJLY_Solenopsis_587

0.890.890.890.890.89

uncultured_Lactobacillus_sp._HM113203_152Lactobacillus_insectis_AY667699_283

Lactobacillus_sp._B3_EU753697_292uncultured_Firmicutes_bacterium_DQ837636_470

0.540.540.540.540.540.470.470.470.470.47

0.190.190.190.190.19

0.260.260.260.260.26

0.450.450.450.450.45

0.300.300.300.300.30

0.040.040.040.040.04

0.000.000.000.000.000.030.030.030.030.03

0.390.390.390.390.39

0.330.330.330.330.330.360.360.360.360.36

0.380.380.380.380.380.350.350.350.350.35

0.210.210.210.210.210.040.040. 040.040.04

0.040.040.040.040.04

0.000.000.000.000.00

0.000.000.000.000.00

0.000.000.000.000.00

0.040.040.040.040.04

0.000.000.000.000.00

0.000.000.000.000.00

0.000.000.000.000.00

0.010.010.010.010.01

0.010.010.010.010.01

0.000.000.000.000.00

0.000.000.000.000.00

0.010.010.010.010.01

0.070.070.070.070.07

0.010.010.010.010.01

0.190.190.190.190.19

0.050.050.050.050.05

0.060.060.060.060.06

0.070.070.070.070.070.050.050. 050.050.050.070.070.070.070.070.030.030.030.030.03

0.000.000.000.000.00

0.000.000.000.000.00

0.000.000.000.000.00

0.010.010.010.010.01

0.070.070.070.070.07

0.110.110.110.110.110.070.070.070.070.07

0.380.380.380.380.38

0.070.070.070.070.07

0.040.040.040.040.04

0.030.030.030.030.03

0.040.040.040.040.04

0.040.040.040.040.04

0.060.060.060.060.06

0.000.000.000.000.00

0.050.050.050.050.05

0.050.050.050.050.05

0.030.030. 030.030.03

0.090.090.090.090.09

0.060.060.060.060.06

0.050.050.050.050.05

0.000.000.000.000.00

0.010.010.010.010.01

0.010.010.010.010.01

0.010.010.010.010.01

0.040.040.040.040.04

0.010.010.010.010.01

0.040.040.040.040.04

0.050.050.050.050.05

0.030.030.030.030.03

0.060.060.060.060.06

0.350.350.350.350.35

0.750.750.750.750.75

Fig. S2 A. Detailed version of Fig. 2, tree based on partial and complete sequences combined. Values at nodes represent bootstrap support, while taxa are color coded as clades or host as in legend at the left.

0.00.100.200.300.400.500.600.700.800.901.01.10

Lactobacillus_concavus_AY683322_076uncultured_bacterium_AM930364_456

1.001.001.001.001.00

Lactobacillus_dextrinicus_D87679_131uncultured_bacterium_AM500777_455

1.001.001.001.001.001.001.001.001.001.00

Lactobacillus_composti_AB268119_058Lactobacillus_perolens_Y19167_260

Lactobacillus_harbinensis_AB368915_129Lactobacillus_brevis_AY974809_168

0.990.990.990.990.991.001.001.001.001.000.450.450.450.450.45

Lactobacillus_floricola_AB523781_173Lactobacillus_sp._MbBipro19_HM534770_312

1.001.001.001.001.00

Lactobacillus_tucceti_LSP576006_181Lactobacillus_nodensis_AB332024_415

0.890.890.890.890.89

Lactobacillus_letivazi_AJ417738_257Lactobacillus_versmoldensis_AJ496791_256

uncultured_bacterium_AF371492_223Lactobacillus_nantensis_AY690834_627Lactobacillus_crustorum_FJ645924_184Lactobacillus_farciminis_AJ417499_254Lactobacillus_mindensis_LSP313530_050

M58804_Lactobacillus_alimentarius_022Lactobacillus_bobalius_AY681134_080

Lactobacillus_kimchii_AF183558_6150.500.500.500.500.500.960.960.960.960.96

0.550.550.550.550.550.330.330.330.330.330.960.960.960.960.96

1.001.001.001.001.000.290.290.290.290.29

0.380.380.380.380.380.260.260.260.260.26

0.740.740.740.740.74

Lactobacillus_sp._Thmro15_HM534814_319uncultured_Lactobacillus_sp._HM113222_148

uncultured_Lactobacillus_sp._HM046576_088uncultured_Firmicutes_bacterium_DQ837632_286Lactobacillus_sp._F7_EU753690_289

0.820.820.820.820.821.001.001.001.001.000.720.720.720.720.72

0.540.540.540.540.54

Lactobacillus_sp._Adhmto19_HM534810_323uncultured_Lactobacillus_sp._HM112055_149

uncultured_Lactobacillus_sp._HM113158_2260.240.240.240.240.240.640.640.640.640.64

uncultured_Firmicutes_bacterium_HM215043_121uncultured_Firmicutes_bacterium_HM215041_119uncultured_Firmicutes_bacterium_HM215042_120

0.970.970.970.970.971.001.001.001.001.00

uncultured_Bacilli_bacterium_HM113258_155uncultured_Firmicutes_bacterium_DQ837631_473uncultured_Firmicutes_bacterium_DQ837630_474

1.001.001.001.001.000.860.860.860.860.861.001.001.001.001.00

0.240.240.240.240.24

0.450.450.450.450.45

Lactobacillus_amylotrophicus_AM236149_114M58806_Lactobacillus_amylophilus_023uncultured_bacterium_AM500848_457

0.960.960.960.960.961.001.001.001.001.00

Bacteria_G2WUYFR01ALAWT_Solenopsis_575Bacteria_G2WUYFR02DXBGU_Solenopsis_561

Lactobacillus_sp._TS3_AB284946_102Bacteria_G2WUYFR01BMLOS_Solenopsis_568

Bacteria_G2WUYFR01AWLV8_Solenopsis_567Bacteria_G2WUYFR02EUU2R_Solenopsis_592

0.650.650.650.650.65

Bacteria_G2WUYFR02D8NSR_Solenopsis_588Bacteria_G2WUYFR01AY213_Solenopsis_609

0.810.810.810.810.81

Bacteria_G2WUYFR02D6JYS_Solenopsis_586Bacteria_G2WUYFR01B9IUO_Solenopsis_602

0.380.380.380.380.38

Bacteria_G2WUYFR02DYQIU_Solenopsis_591Bacteria_G2WUYFR01CEH5G_Solenopsis_599

0.750.750.750.750.750.380.380.380.380.38

0.280.280.280.280.28

0.340.340.340.340.340.210.210.210.210.21

0.330.330.330.330.330.750.750.750.750.75

0.050.050.050.050.05

0.040.040.040.040.04

0.000.000.000.000.00

Lactobacillus_fuchuensis_AB370875_109Lactobacillus_graminis_AM113778_045Bacteria_G28NS4E02EPXZY_Solenopsis_583Lactobacillus_curvatus_AM113777_621

0.340.340.340.340.34

Lactobacillus_sakei_EU555174_224uncultured_bacterium_DQ922980_431

0.810.810.810.810.81

Bacteria_G2WUYFR01BCWHI_Solenopsis_580Bacteria_G2WUYFR01BEKHY_Solenopsis_562Bacteria_G2WUYFR01BNE8X_Solenopsis_596

0.360.360.360.360.36

Bacteria_G2WUYFR01BQJEU_Solenopsis_569Bacteria_G2WUYFR01B93S1_Solenopsis_597

0.200.200.200.200.200.510.510.510.510.510.140.140.140.140.14

0.170.170.170.170.170.500.500.500.500.50

0.860.860.860.860.86

Lactobacillus_thailandensis_AB257863_060Lactobacillus_pantheris_AB362679_172

0.990.990.990.990.99

uncultured_compost_bacterium_FN667294_204uncultured_bacterium_AF371503_244

M58831_Lactobacillus_sharpeae_033Bacteria_G2WUYFR02D4CBL_Solenopsis_581

0.990.990.990.990.99

Lactobacillus_guizhouensis_GU138576_113Lactobacillus_guizhouensis_EF433578_124

0.500.500.500.500.500.960.960.960.960.96

0.910.910.910.910.910.340.340.340.340.34

0.740.740.740.740.74

Lactobacillus_camelliae_AB257864_074uncultured_bacterium_GQ477902_196

uncultured_bacterium_GQ477899_2400.780.780.780.780.780.970.970.970.970.97

Bacteria_G2WUYFR02D1R7T_Solenopsis_560uncultured_compost_bacterium_FN667075_209Lactobacillus_nasuensis_AB608051_412

1.001.001.001.001.000.300.300.300.300.30

Lactobacillus_manihotivorans_AF000163_259Bacteria_G2WUYFR02D23R9_Solenopsis_570

uncultured_compost_bacterium_FN667077_210Bacteria_G2WUYFR02DXNIT_Solenopsis_604

0.780.780.780.780.780.350.350.350.350.350.600.600.600.600.60

0.720.720.720.720.72

0.380.380.380.380.38

Lactobacillus_saniviri_AB602569_307Lactobacillus_sp._Akpobro1_HM534767_314

1.001.001.001.001.00

Lactobacillus_sp._LM_17_AJ132757_417Lactobacillus_rhamnosus_EU184020_170

Lactobacillus_sp._N3_1_1_AB379909_2490.850.850.850.850.850.260.260.260.260.26

Lactobacillus_zeae_D86516_613X61135_Lactobacillus_casei_039M23928_Lactobacillus_casei_040Bacteria_G4RPUYA02DO5UR_Mycocepurus_498Bacteria_G4RPUYA02DGY9G_Mycocepurus_503

Bacteria_G4RPUYA02C44TI_Mycocepurus_553

0.850.850.850.850.850.800.800.800.800.80

0.460.460.460.460.46

Lactobacillus_larvae_AY667700_464Lactobacillus_GeEuF1Bc0029_G1OJGBH03GBVJ2_383

Lactobacillus_GeEuL2Bc0029_G1OJGBH03FPFCW_399Lactobacillus_paracasei_AY773954_215

Lactobacillus_sp._N1_5_2_AB379908_2510.360.360.360.360.36

Lactobacillus_sp._N4_4_AB379912_452Bacteria_G2WUYFR02D35PT_Solenopsis_566

0.390.390.390.390.39

Lactobacillus_GeEuF1Bc0029_G1OJGBH03G7UHR_377Lactobacillus_GeEuF1Bc0029_G1OJGBH03HE4SG_381Lactobacillus_GeEuF1Bc0029_G1OJGBH03GD18U_386Lactobacillus_GeEuF1Bc0029_G1OJGBH03FXRZZ_396Lactobacillus_GeEuF1Bc0029_G1OJGBH03HA4AJ_401

0.680.680.680.680.680.300.300.300.300.300.130.130.130.130.13

0.130.130.130.130.13

0.190.190.190.190.19

0.060.060.060.060.06

0.500.500.500.500.50

0.300.300.300.300.30

0.260.260.260.260.26

0.010.010.010.010.01

0.040.040.040.040.04

0.010.010.010.010.01

0.040.040.040.040.04

0.050.050.050.050.05

0.00.100.200.300.400.500.600.700.800.901.01.101.201.301.401.50

Carnobacterium_divergens_NR_044706_280Carnobacterium_maltaromaticum_NR_044710_281

0.720.720.720.720.72

Abiotrophia_defectiva_ATCC_49176_NR_025863_284Eremococcus_coleocola_NR_026481_287

1.001.001.001.001.000.970.970.970.970.97

Listeria_rocourtiae_FJ557241_056Bacillus_thuringiensis_str._Al_Hakam_CP000485_ag_069

Bacillus_coagulans_AF466695_2780.970.970.970.970.970.990.990.990.990.99

Enterococcus_moraviensis_NR_028794_279Enterococcus_hirae_NR_037082_272AY735408_Enterococcus_faecium_002Enterococcus_faecium_EF533987_092

1.001.001.001.001.000.970.970.970.970.970.990.990.990.990.99

Streptococcus_parasanguinis_ATCC_15912_NR_024842_275Lactococcus_lactis_subsp._lactis_KF147_NC_013656_BF_266Lactococcus_lactis_subsp._lactis_KF147_NC_013656_T_267Lactococcus_lactis_subsp._lactis_KF147_NC_013656_BQ_268Lactococcus_lactis_subsp._lactis_KF147_NC_013656_CB_269Lactococcus_lactis_subsp._lactis_KF147_NC_013656_CH_270Lactococcus_lactis_subsp._lactis_KF147_NC_013656_BM_271

1.001.001.001.001.001.001.001.001.001.00

0.680.680.680.680.68

0.680.680.680.680.68

0.400.400.400.400.40

Weissella_kandleri_NR_044659_274Bacteria_G2WUYFR02DPIHT_Solenopsis_590

0.640.640.640.640.64

M58809_Lactobacillus_bifermentans_025Lactobacillus_bifermentans_JN175330_205

Bacteria_G2WUYFR02DS0HK_Solenopsis_5551.001.001.001.001.00

Lactobacillus_backi_DQ406862_122M58813_Lactobacillus_coryniformis_026uncultured_bacterium_GQ479965_192

1.001.001.001.001.00

Lactobacillus_rennini_LSP576007_046Lactobacillus_halophilus_AB240455_081

1.001.001.001.001.000.790.790.790.790.79

0.800.800.800.800.800.990.990.990.990.99

Paralactobacillus_selangorensis_NR_024885_282Lactobacillus_algidus_AB033209_277Lactobacillus_satsumensis_AB362683_166Lactobacillus_oeni_EU821345_180

0.930.930.930.930.93

Lactobacillus_cacaonum_AM905389_079M58824_Lactobacillus_mali_029

Lactobacillus_hordei_EU074850_147Lactobacillus_mali_FJ157230_225

0.960.960.960.960.960.640.640.640.640.640.960.960.960.960.96

Lactobacillus_capillatus_AB365978_052Lactobacillus_sucicola_AB458681_087

0.570.570.570.570.57

Lactobacillus_uvarum_EU345000_075Lactobacillus_sp._IMCC1736_DQ664203_078

0.680.680.680.680.680.880.880.880.880.88

0.630.630.630.630.63

0.260.260.260.260.26

Lactobacillus_nagelii_AB162131_073Lactobacillus_ghanensis_DQ523489_133

1.001. 001.001.001.00

Lactobacillus_mobilis_AB242320_188uncultured_Lactobacillus_sp._HM218831_198

uncultured_Lactobacillus_sp._HM218848_097uncultured_Lactobacillus_sp._HM218858_445

1.001.001.001.001.001.001.001.001.001.000.860.860.860.860.86

0.900.900.900.900.90

M58807_Lactobacillus_animalis_024Lactobacillus_apodemi_AJ871178_070uncultured_bacterium_DQ075206_041Lactobacillus_murinus_AJ621554_134

uncultured_bacterium_DQ815470_203uncultured_bacterium_DQ815437_216

0.930.930.930.930.93

uncultured_bacterium_EU791129_449uncultured_bacterium_EU790976_453

0.820.820.820.820.82

Lactobacillus_Q2_F7SSZP003G8XXC_330uncultured_bacterium_EU791098_446

0.810.810.810.810.81

Lactobacillus_Q9_F7SSZP003GEOFA_358Lactobacillus_Q1_F7SSZP003G0JMG_353Lactobacillus_Q1_F7SSZP003FIY29_362

1.001.001.001.001.000.810.810.810.810.810.310.310.310.310.31

0.470.470.470.470.47

0.800.800.800.800.80

0.950.950.950.950.95

Lactobacillus_equi_AB425924_190Bacteria_G4RPUYA02C9XKQ_Mycocepurus_476

M58803_Lactobacillus_agilis_021uncultured_bacterium_AB559729_186

0.650.650.650.650.650.810.810.810.810.811.001.001.001.001. 00

Lactobacillus_sp._C33LV5_AF197125_262uncultured_bacterium_AB506300_187M58828_Lactobacillus_ruminis_030Lactobacillus_ruminis_AB326354_112

0.590.590.590.590.591.001.001.001.001.000.950.950.950.950.95

0.360.360.360.360.36

Lactobacillus_ceti_AM292799_150Lactobacillus_saerimneri_AY255802_227Lactobacillus_sp._MbBipro17_HM534774_325Lactobacillus_sp._Tporo2_HM534775_324Lactobacillus_pobuzihii_AB326365_111Lactobacillus_sp._MbBbr1_HM534771_321

Lactobacillus_sp._121B_AF305930_261Lactobacillus_acidipiscis_AB023836_617

0.630.630.630.630.630.450.450.450.450.450.800.800.800.800.80

0.650.650.650.650.651.001.001.001.001.00

Lactobacillus_hayakitensis_AB267406_118uncultured_bacterium_AY212750_418

1.001.001.001.001.00

Bacteria_G4RPUYA02EQEGE_Mycocepurus_494Lactobacillus_salivarius_AB186340_107Lactobacillus_salivarius_EU428010_141

Bacteria_G4RPUYA02DHK61_Mycocepurus_477uncultured_Lactobacillus_sp._AY672088_235Bacteria_G4RPUYA02DJDFD_Mycocepurus_489Bacteria_G4RPUYA02EYMBR_Mycocepurus_540

Bacteria_G2WUYFR01BYHUN_Solenopsis_557Bacteria_G4RPUYA02D1FDL_Mycocepurus_483

Bacteria_G4SXT0Z01B916P_Solenopsis_5650.330.330.330.330.330.720.720.720.720.72

0.240.240.240.240.24

0.190.190.190.190.190.710.710.710.710.71

0.590.590.590.590.59

Bacteria_G4RPUYA02DQ24F_Mycocepurus_487uncultured_bacterium_GU293196_197

Lactobacillus_intermedius_AB167386_090Bacteria_G2WUYFR02DBVUH_Solenopsis_606

0.510.510.510.510.510.230.230.230.230.23

Bacteria_G2WUYFR01AL9EQ_Solenopsis_576Lactobacillus_GeEuTuBc0029_G1OJGBH03GOLAZ_376Lactobacillus_aviarius_AB001837_276Bacteria_G4RPUYA02EBAXL_Mycocepurus_538

0.630.630.630.630.63

Bacteria_G4RPUYA02EALIM_Mycocepurus_479Bacteria_G4RPUYA02EECR6_Mycocepurus_478

Bacteria_G4RPUYA02DLZY4_Mycocepurus_542Bacteria_G4RPUYA02ECJZU_Mycocepurus_504Bacteria_G4RPUYA02DSRND_Mycocepurus_481

Bacteria_G4RPUYA02EHKZP_Mycocepurus_4820.460.460.460.460.46

Bacteria_G4RPUYA02EKHNN_Mycocepurus_490Bacteria_G4RPUYA02DOSON_Mycocepurus_485

Bacteria_G4RPUYA02C1C45_Mycocepurus_5230.240.240.240.240.240.100.100.100.100.100.140.140.140.140.14

Bacteria_G4RPUYA02DCJC6_Mycocepurus_501Bacteria_G4RPUYA02EGVOD_Mycocepurus_539

0.700.700.700.700.70

Bacteria_G4RPUYA02EDTH9_Mycocepurus_493Bacteria_G4RPUYA02D8Y4Y_Mycocepurus_499

Bacteria_G4RPUYA02DJDR6_Mycocepurus_5160.500.500.500.500.500.260.260.260.260.26

0.900.900.900.900.90

0.100.100.100.100.10

0.240.240.240.240.24

0.310.310.310.310.310.310.310.310.310.310.200.200.200.200.200.500.500.500.500.50

0.290.290.290.290.290.500.500.500.500.50

0.070.070.070.070.07

0.130.130.130.130.13

0.230.230.230.230.23

0.350.350.350.350.35

0.250.250.250.250.25

0.540.540.540.540.54

0.420.420.420.420.42

0.610.610.610.610.61

0.540.540.540.540.54

Lactobacillus_concavus_AY683322_076uncultured_bacterium_AM930364_456

1.001.001.001.001.00

Lactobacillus_dextrinicus_D87679_131uncultured_bacterium_AM500777_455

1.001.001.001.0 01.001.001.001.001.001.00

Lactobacillus_composti_AB268119_058Lactobacillus_perolens_Y19167_260

Lactobacillus_harbinensis_AB368915_129Lactobacillus_brevis_AY974809_168

0.990.990.990.990.991.001.001.001.001.000.450.450.450.450.45

Lactobacillus_floricola_AB523781_173Lactobacillus_sp._MbBipro19_HM534770_312

1.001.001.001.001.00

Lactobacillus_tucceti_LSP576006_181Lactobacillus_nodensis_AB332024_415

0.890.890.890.890.89

Lactobacillus_letivazi_AJ417738_257Lactobacillus_versmoldensis_AJ496791_256

uncultured_bacterium_AF371492_223Lactobacillus_nantensis_AY690834_627Lactobacillus_crustorum_FJ645924_184Lactobacillus_farciminis_AJ417499_254Lactobacillus_mindensis_LSP313530_050

M58804_Lactobacillus_alimentarius_022Lactobacillus_bobalius_AY681134_080

Lactobacillus_kimchii_AF183558_6150.500.500.500.500.500.960.960.960.960.96

0.550.550.550.550.550.330.330.330.330.330.960.960.960.960.96

1.001.001.001.001.000.290.290.290.290.29

0.380 .380.380.380.380.260.260.260.260.26

0.740.740.740.740.74

Lactobacillus_sp._Thmro15_HM534814_319uncultured_Lactobacillus_sp._HM113222_148

uncultured_Lactobacillus_sp._HM046576_088uncultured_Firmicutes_bacterium_DQ837632_286Lactobacillus_sp._F7_EU753690_289

0.820.820.820.820.821.001.001.001.001.000.720.720.720.720.72

0.540.540.540.540.54

Lactobacillus_sp._Adhmto19_HM534810_323uncultured_Lactobacillus_sp._HM112055_149

uncultured_Lactobacillus_sp._HM113158_2260.240.240.240.240.240.640.640.640.640.64

uncultured_Firmicutes_bacterium_HM215043_121uncultured_Firmicutes_bacterium_HM215041_119uncultured_Firmicutes_bacterium_HM215042_120

0.970.970.970.970.971.001.001.001.001.00

uncultured_Bacilli_bacterium_HM113258_155uncultured_Firmicutes_bacterium_DQ837631_473uncultured_Firmicutes_bacterium_DQ837630_474

1.001.001.001.001.000.860.860.860.860 .861.001.001.001.001.00

0.240.240.240.240.24

0.450.450.450.450.45

Lactobacillus_amylotrophicus_AM236149_114M58806_Lactobacillus_amylophilus_023uncultured_bacterium_AM500848_457

0.960.960.960.960.961.001.001.001.001.00

Bacteria_G2WUYFR01ALAWT_Solenopsis_575Bacteria_G2WUYFR02DXBGU_Solenopsis_561

Lactobacillus_sp._TS3_AB284946_102Bacteria_G2WUYFR01BMLOS_Solenopsis_568

Bacteria_G2WUYFR01AWLV8_Solenopsis_567Bacteria_G2WUYFR02EUU2R_Solenopsis_592

0.650.650.650.650.65

Bacteria_G2WUYFR02D8NSR_Solenopsis_588Bacteria_G2WUYFR01AY213_Solenopsis_609

0.810.810.810.810.81

Bacteria_G2WUYFR02D6JYS_Solenopsis_586Bacteria_G2WUYFR01B9IUO_Solenopsis_602

0.380.380.380.380.38

Bacteria_G2WUYFR02DYQIU_Solenopsis_591Bacteria_G2WUYFR01CEH5G_Solenopsis_599

0.750.750.750.750.750.380.380.380.380.38

0.280.280.280.280.28

0.340.340.340.340.340.210.210.210.210.21

0.330.330.330.330.330.750.750.750.750 .75

0.050.050.050.050.05

0.040.040.040.040.04

0.000.000.000.000.00

Lactobacillus_fuchuensis_AB370875_109Lactobacillus_graminis_AM113778_045Bacteria_G28NS4E02EPXZY_Solenopsis_583Lactobacillus_curvatus_AM113777_621

0.340.340.340.340.34

Lactobacillus_sakei_EU555174_224uncultured_bacterium_DQ922980_431

0.810.810.810.810.81

Bacteria_G2WUYFR01BCWHI_Solenopsis_580Bacteria_G2WUYFR01BEKHY_Solenopsis_562Bacteria_G2WUYFR01BNE8X_Solenopsis_596

0.360.360.360.360.36

Bacteria_G2WUYFR01BQJEU_Solenopsis_569Bacteria_G2WUYFR01B93S1_Solenopsis_597

0.200.200.200.200.200.510.510.510.510.510.140.140.140.140.14

0.170.170.170.170.170.500.500.500.500.50

0.860.860.860.860.86

Lactobacillus_thailandensis_AB257863_060Lactobacillus_pantheris_AB362679_172

0.990.990.990.990.99

uncultured_compost_bacterium_FN667294_204uncultured_bacterium_AF371503_244

M58831_Lactobacillus_sharpeae_033Bacteria_G2WUYFR02D4CBL_Solenopsis_581

0 .990.990.990.990.99

Lactobacillus_guizhouensis_GU138576_113Lactobacillus_guizhouensis_EF433578_124

0.500.500.500.500.500.960.960.960.960.96

0.910.910.910.910.910.340.340.340.340.34

0.740.740.740.740.74

Lactobacillus_camelliae_AB257864_074uncultured_bacterium_GQ477902_196

uncultured_bacterium_GQ477899_2400.780.780.780.780.780.970.970.970.970.97

Bacteria_G2WUYFR02D1R7T_Solenopsis_560uncultured_compost_bacterium_FN667075_209Lactobacillus_nasuensis_AB608051_412

1.001.001.001.001.000.300.300.300.300.30

Lactobacillus_manihotivorans_AF000163_259Bacteria_G2WUYFR02D23R9_Solenopsis_570

uncultured_compost_bacterium_FN667077_210Bacteria_G2WUYFR02DXNIT_Solenopsis_604

0.780.780.780.780.780.350.350.350.350.350.600.600.600.600.60

0.720.720.720.720.72

0.380.380.380.380.38

Lactobacillus_saniviri_AB602569_307Lactobacillus_sp._Akpobro1_HM534767_314

1.001.001.001.0 01.00

Lactobacillus_sp._LM_17_AJ132757_417Lactobacillus_rhamnosus_EU184020_170

Lactobacillus_sp._N3_1_1_AB379909_2490.850.850.850.850.850.260.260.260.260.26

Lactobacillus_zeae_D86516_613X61135_Lactobacillus_casei_039M23928_Lactobacillus_casei_040Bacteria_G4RPUYA02DO5UR_Mycocepurus_498Bacteria_G4RPUYA02DGY9G_Mycocepurus_503

Bacteria_G4RPUYA02C44TI_Mycocepurus_553

0.850.850.850.850.850.800.800.800.800.80

0.460.460.460.460.46

Lactobacillus_larvae_AY667700_464Lactobacillus_GeEuF1Bc0029_G1OJGBH03GBVJ2_383

Lactobacillus_GeEuL2Bc0029_G1OJGBH03FPFCW_399Lactobacillus_paracasei_AY773954_215

Lactobacillus_sp._N1_5_2_AB379908_2510.360.360.360.360.36

Lactobacillus_sp._N4_4_AB379912_452Bacteria_G2WUYFR02D35PT_Solenopsis_566

0.390.390.390.390.39

Lactobacillus_GeEuF1Bc0029_G1OJGBH03G7UHR_377Lactobacillus_GeEuF1Bc0029_G1OJGBH03HE4SG_381Lactobacillus_GeEuF1Bc0029_G1OJGBH03GD18U_386Lactobacillus_GeEuF1Bc0029_G1OJGBH03FXRZZ_396Lactobacillus_GeEuF1Bc0029_G1OJGBH03HA4AJ_401

0.680.680.680.680.680.300.300.300.300.300.130.130.130.130.13

0.130.130.130.130.13

0.190.190.190.190.19

0.060.060.060.060.06

0 .500.500.500.500.50

0.300.300.300.300.30

0.260.260.260.260.26

Pediococcus_pentosaceus_AB362987_053Bacteria_G2WUYFR02EYU2C_Solenopsis_608

0.530.530.530.530.53

uncultured_compost_bacterium_FN667076_208uncultured_bacterium_AF371496_213

0.780.780.780.780.78

Lactobacillus_senmaizukei_AB297927_414Lactobacillus_hammesii_AJ632219_043Lactobacillus_parabrevis_AM158249_095

Lactobacillus_sp._1.1424_FN185731_099uncultured_compost_bacterium_FN667298_211

0.590.590.590.590.590.590.590.590.590.590.090.090.090.090.090.360.360.360.360.36

Lactobacillus_brevis_ATCC_367_CP000416_f_177Bacteria_G2WUYFR02C9Q6O_Solenopsis_578

M58810_Lactobacillus_brevis_014X61134_Lactobacillus_brevis_013Bacteria_G2WUYFR01BA4B4_Solenopsis_564

0.410.410.410.410.41

Lactobacillus_brevis_ATCC_367_CP000416_o_176Lactobacillus_brevis_ATCC_367_CP000416_l_179Lactobacillus_brevis_ATCC_367_CP000416_c_174Lactobacillus_brevis_ATCC_367_CP000416_175

0.240.240.240.240.240.400.400.400.400.40

Bacteria_G2WUYFR02EUR0O_Solenopsis_574Bacteria_G2WUYFR01CAH48_Solenopsis_603

0.970.970.970.970.97

Lactobacillus_spicheri_LSP534844_059Lactobacillus_namurensis_AM259118_096

Lactobacillus_acidifarinae_AJ632158_093Lactobacillus_zymae_AJ632157_094

0.990.990.990.990.990.910.910.910.910.910.700.700.700.700.70

0.470.470.470.470.47

0.280.280.280.280.28

0.470.470.470.470.47

0.420.420.420.420.42

0.340.340.340.340.34

Lactobacillus_senioris_AB602570_298Lactobacillus_sp._Akporo7_HM534765_311

1.001.001.001.001.00

Lactobacillus_sp._JKD6_AF264701_614Lactobacillus_parafarraginis_AB262734_622

Lactobacillus_sp._r2_GQ247886_123M58821_Lactobacillus_hilgardii_017M59295_Lactobacillus_sp._034

0.440.440.440.440.440.950.950.950.950.95

Lactobacillus_farraginis_HM534766_139Lactobacillus_farraginis_AB262732_183Lactobacillus_faeni_AB362687_428

0.600.600.600.600.601.001.001.001.001.000.780.780.780.780.78

0.600.600.600.600.600.250.250 .250.250.25

Lactobacillus_sp._NGRI_0130_AB362984_250Lactobacillus_rapi_AB366389_624

0.950.950.950.950.95

Lactobacillus_kisonensis_AB366388_628Lactobacillus_sp._rennanqilfy19_AY363377_237Lactobacillus_parabuchneri_AB205056_626

0.570.570.570.570.57

Lactobacillus_fermentum_FJ844993_130Lactobacillus_kefiri_AJ621553_135

1.001.001.001.001.00

Lactobacillus_otakiensis_AB366386_620Lactobacillus_sunkii_AB366385_625M58811_Lactobacillus_buchneri_015Lactobacillus_parakefiri_AY026750_612

0.860.860.860.860.860.400.400.400.400.400.380.380.380.380.380.640.640.640.640.640.840.840.840.840.840.510.510.510.510.510.510.510.510.510.51

0.820.820.820.820.82

0.890.890.890.890.89

Lactobacillus_ozensis_AB572588_051Lactobacillus_sp._MbBipro7_HM534743_313

0.960.960.960.960.96

uncultured_Bacilli_bacterium_HM112474_145uncultured_Lactobacillus_sp._HM008721_068

Lactobacillus_sp._Am_09_AJ971903_295Lactobacillus_kunkeei_AB559820_185Lactobacillus_kunkeei_EU753691_291

0.990.990.990.990.990.550.550.550.550.550.960 .960.960.960.960.550.550.550.550.55

uncultured_Bacilli_bacterium_HM109480_143uncultured_Bacilli_bacterium_HM109610_144uncultured_Bacilli_bacterium_HM112778_146

0.990.990.990.990.99

uncultured_Bacilli_bacterium_HM112623_467Lactobacillus_Q7A_F348WMR04JBQ2M_333Lactobacillus_Q7A_F348WMR04JGOIJ_334

Lactobacillus_Q7A_F348WMR04IFQ7D_360Lactobacillus_Q7A_F348WMR04JDJG4_363

Lactobacillus_Q7A_F348WMR04JKTXT_340Lactobacillus_Q7A_F348WMR04JKJ8J_611

1.001.001.001.001.000.230.230.230.230.230.610.610.610.610.610.230.230.230.230.23

0.240.240.240.240.240.410.410.410.410.41

0.490.490.490.490.49

Lactobacillus_GeEuF1Bc0029_G1OJGBH03GX6IB_397Lactobacillus_GeEuF1Bc0029_G1OJGBH03G5C2A_398Lactobacillus_GeEuF1Bc0029_G1OJGBH03HAYWD_403

0.400.400.400.400.400.970.970.970.970.97

Lactobacillus_GeSoB2Bc0019_G1OJGBH03FWMY4_392Lactobacillus_GeSoB2Bc0019_G1OJGBH03GHBHU_382

Lactobacillus_GeSoB2Bc0019_G1OJGBH03FQASF_390Lactobacillus_GeEuB2Bc0029_G1OJGBH03G4ZG5_389Lactobacillus_GeEuA1Bc0029_G1OJGBH03GHVOY_407Lactobacillus_GeEuPeBc0029_G1OJGBH03FN2ZU_366Lactobacillus_GeEuF1Bc0029_G1OJGBH03GZEIB_379Lactobacillus_GeEuL2Bc0029_G1OJGBH03G5A0S_404Lactobacillus_GeEuB2Bc0029_G1OJGBH03F1OGP_372Lactobacillus_GeEuPeBc0029_G1OJGBH03G6R03_373Lactobacillus_GeEuL2Bc0029_G1OJGBH03F6ICY_393

0.260.260.260.260.26

Lactobacillus_GeSoL1Bc0019_G1OJGBH03GQQ4M_370Lactobacillus_GeEuPeBc0029_G1OJGBH03F3HKE_395

Lactobacillus_GeSoB2Bc0019_G1OJGBH03HCW2S_384Lactobacillus_GeEuB2Bc0029_G1OJGBH03FPP40_408

0.330.330.330.330.33

Lactobacillus_GeEuF1Bc0029_G1OJGBH03FKN70_385Lactobacillus_GeEuF1Bc0029_G1OJGBH03F5LSE_409

Lactobacillus_GeEuF1Bc0029_G1OJGBH03G4BBA_394Lactobacillus_GeEuF1Bc0029_G1OJGBH03GL6DL_400

0.400.400.400.400.400.550.550.550.550.550.310.310.310.310.31

0.070.070.070.070.07

0.010.010.010.010.010.040.040.040.040.040.030.030.030.030.03

0.100.100.100.100.10

0.390.390.390.390.39

0.130.130.130.130.130.160.160.160.160.16

0.330.330.330.330.33

0.360.360.360.360.36

0.360.360.360.360 .36

Lactobacillus_sp._MbBipto3_HM534760_308Lactobacillus_sp._Mbhoto3_HM534763_310

1.001.001.001.001.00

X76330|g535112_Lactobacillus_fructivorans_028Lactobacillus_homohiochii_AJ621552_128

0.960.960.960.960.96

Lactobacillus_sp._Akhmbto4_HM534764_306Lactobacillus_florum_AB498047_048Lactobacillus_florum_AB498046_103

1.001.001.001.001.00

Lactobacillus_lindneri_X95421_252X61132_Lactobacillus_sanfrancisco_031X76327|g535106_Lactobacillus_sanfrancisco_032

1.001.001.001.001.000.860.860.860.860.860.820.820.820.820.82

1.001.001.001.001.000.930.930.930.930.93

Lactobacillus_Q13_F7SSZP003FI5FN_326Lactobacillus_Q13_F7SSZP003HFPEY_331Lactobacillus_Q13_F7SSZP003G5ZTS_349

Lactobacillus_Q1_F7SSZP003G3NEK_3520.790.790.790.790.790.190.190.190.190.19

0.230.230.230.230.23

Lactobacillus_Q1_F7SSZP003GUV9L_378Lactobacillus_Q11_F7SSZP003GTXXJ_354Lactobacillus_Q1_F7SSZP003GSQA4_329

Lactobacillus_Q1_F7SSZP003GRNEB_339Lactobacillus_Q1_F7SSZP003F337Q_327Lactobacillus_Q1_F7SSZP003HB7B3_332

0.560.560.560.560.560.360.360.360.360.36

Lactobacillus_Q11_F7SSZP003HHA6K_338Lactobacillus_Q1_F7SSZP003HBKSR_328

Lactobacillus_Q1_F7SSZP003HHGTB_3350.400.400.400.400.400.130.130.130.1 30.13

0.400.400.400.400.400.820.820.820.820.82

0.900.900.900.900.90

Lactobacillus_Q13_F7SSZP003FP9MZ_359Lactobacillus_Q1_F7SSZP003GZRYO_348

Lactobacillus_Q13_F7SSZP003GTPZN_375Lactobacillus_Q13_F7SSZP003FK90P_365Lactobacillus_Q1_F7SSZP003GVG3B_367

0.280.280.280.280.28

Lactobacillus_Q13_F7SSZP003FNTFE_361Lactobacillus_Q1_F7SSZP003G9G18_364

Lactobacillus_Q1_F7SSZP003FO813_3740.530.530.530.530.530.050.050.050.050.050.070.070.070.070.07

Lactobacillus_Q1_F7SSZP003F6H96_369Lactobacillus_Q13_F7SSZP003GLX8O_347

Lactobacillus_Q1_F7SSZP003HB207_344Lactobacillus_Q13_F7SSZP003GSJYU_350Lactobacillus_Q1_F7SSZP003G83HT_355Lactobacillus_Q1_F7SSZP003FQFVI_368

0.930.930.930.930.930.820.820.820.820.82

Lactobacillus_Q1_F7SSZP003FVDOE_343Lactobacillus_Q1_F7SSZP003GB27S_351

Lactobacillus_Q1_F7SSZP003FZBLV_345Lactobacillus_Q13_F7SSZP003HAPYQ_346

Lactobacillus_Q1_F7SSZP003FZDPQ_356Lactobacillus_Q1_F7SSZP003FJ41T_341

Lactobacillus_Q1_F7SSZP003FKU5E_3570.460.460.460.460.46

Lactobacillus_Q1_F7SSZP003FV2DK_342Lactobacillus_Q13_F7SSZP003GM303_371

0.130.130.130.130.130.030.030.030.030.03

0.010.010.010.010.010.090.090.090.090.09

0.030.030.030.030.030.000.0 00.000.000.000.050.050.050.050.05

0.060.060.060.060.060.070.070.070.070.07

0.070.070.070.070.070.050.050.050.050.05

0.040.040.040.040.04

0.030.030.030.030.03

0.060.060.060.060.06

0.070.070.070.070.07

0.200.200.200.200.20

0.630.630.630.630.63

0.300.300.300.300.30

0.260.260.260.260.26

0.390.390.390.390.39

0.310.310.310.310.31

0.070.070.070.070.07

0.060.060.060.060.06

Lactobacillus_malefermentans_AM113783_182Bacteria_G2WUYFR02DUYD5_Solenopsis_559

0.990.990.990.990.99

Lactobacillus_sp._DCY51_EU678893_106Bacteria_G2WUYFR02DN04P_Solenopsis_556

Lactobacillus_collinoides_AB005893_044Lactobacillus_paracollinoides_AB159218_167

1.001.001.001 .001.00

Lactobacillus_odoratitofui_AB365975_108Lactobacillus_similis_AB282889_077Bacteria_G2WUYFR02ERHIP_Solenopsis_600

0.640.640.640.640.640.460.460.460.460.460.540.540.540.540.54

0.510.510.510.510.510.740.740.740.740.74

0.800.800.800.800.80

uncultured_bacterium_AF371494_220Lactobacillus_GeEuF1Bc0029_G1OJGBH03F8WFB_405

Bacteria_G2WUYFR02DVW1P_Solenopsis_598Bacteria_G28NS4E02DMQ1E_Solenopsis_594

Bacteria_G2WUYFR02D1WHH_Solenopsis_572Bacteria_G2WUYFR02D5DLK_Solenopsis_607

0.880.880.880.880.880.200.200.200.200.20

Lactobacillus_fabifermentans_AM905388_072Lactobacillus_plantarum_FJ915797_245

Bacteria_G28NS4E02EJUZ3_Solenopsis_601Lactobacillus_plantarum_JN126052_160

Lactobacillus_japonicus_AB681817_411Bacteria_G28NS4E02C3G8Q_Solenopsis_577

Bacteria_G28NS4E02DIEI6_Solenopsis_5930.510.510.510.510.51

0.030.030.030.030.03

Lactobacillus_plantarum_AJ965482_127D79211_Lactobacillus_pentosus_018

Lactobacillus_plantarum_AM279758_2020.100.100.100.100.10

M58827_Lactobacillus_plantarum_019Lactobacillus_plantarum_FJ386491_169

0.240.240.240.240.24

Lactobacillus_plantarum_FN252881_447Lactobacillus_plantarum_AB371712_238

Bacteria_G2WUYFR02DYMES_Solenopsis_6100.760.760.760.760.760.300.300.300.300.30

Lactobacillus_plantarum_AB371714_248Bacteria_G4RPUYA02D9F7Z_Mycocepurus_531

Bacteria_G28NS4E02DQD3U_Solenopsis_5580.600.600.600.600.600.130.130.130.130.13

0.060.060.060.060.06

0.030.030.030.030.03

0.010.010.010.010.01

0.140.140.140.140.14

0.340.340.340.340.34

0.090.090.090.090.09

0.500.500.500.500.50

0.760.760.760.760.76

0.140.140.140.140.14

Lactobacillus_siliginis_AB370882_413Lactobacillus_rossiae_LSP564009_156Lactobacillus_rossiae_AM920328_061Bacteria_G4RPUYA02DO47R_Mycocepurus_541

0.590.590.590.590.59

Lactobacillus_GeEuF1Bc0029_G1OJGBH03GO5Q0_380Lactobacillus_GeEuF1Bc0029_G1OJGBH03HCYM0_388Lactobacillus_GeEuF1Bc0029_G1OJGBH03FYH6Y_406

Lactobacillus_GeEuF1Bc0029_G1OJGBH03G2VUK_391Lactobacillus_GeEuF1Bc0029_G1OJGBH03G2OEC_402

0.850.850.850.850.850.590.590.590.590.590.590.590.590.590.59

0.690.690.690.690.691.001.001.001.001.00

Lactobacillus_suebicus_LSU575744_162Lactobacillus_vaccinostercus_AB362691_419Bacteria_G2WUYFR02DYIH7_Solenopsis_573

1.001.001.001.001.000.970.970.970.970.97

Lactobacillus_oligofermentans_AY733084_110uncultured_bacterium_HQ716645_236

0.530.530.530.530.53

Bacteria_G2WUYFR02EJBF3_Solenopsis_595Bacteria_G4RPUYA02EP6UO_Mycocepurus_488

Bacteria_G4RPUYA02D4F5G_Mycocepurus_5140.910.910.910.910.910.610.610.610.610.61

0.990.990.990.990.99

0.840.840.840.840.84

Lactobacillus_equigenerosi_AB288050_091Lactobacillus_antri_AY253658_157

0.850.850.850.850.85

Lactobacillus_fermentum_AF522394_253Lactobacillus_fermentum_EF535257_234

Bacteria_G2WUYFR01A00YD_Solenopsis_585M58819_Lactobacillus_fermentum_027Lactobacillus_fermentum_GQ131191_132

0.460.460.460.460.460.190.190.190.190.19

1.001.001.001.001.000.750.750.750.750.75

Lactobacillus_sp._G24_AF197126_258Lactobacillus_mucosae_AF126738_616

1.001.001.001.001.00

Lactobacillus_alvi_HQ718585_410Lactobacillus_ingluviei_AF308147_255

Bacteria_G4RPUYA02D2F2O_Mycocepurus_4961. 001.001.001.001.000.760.760.760.760.76

Lactobacillus_sp._TMW_1.1309_AM279150_189uncultured_bacterium_AB559717_435Lactobacillus_coleohominis_AM113776_623

1.001.001.001.001.00

Lactobacillus_sp._oral_taxon_052_GQ422710_042X94230|g1313964_Lactobacillus_panis_038

uncultured_bacterium_GQ505032_4540.780.780.780.780.78

uncultured_bacterium_HM218875_432Lactobacillus_kalixensis_AY253659_158X94229|g1313963_Lactobacillus_oris_035uncultured_bacterium_AB559668_434

0.970.970.970.970.970.990.990.990.990.990.530.530.530.530.531.001.001.001.001.00

uncultured_bacterium_AY958911_433X61136_Lactobacillus_vaginalis_036

Lactobacillus_vaginalis_HM534769_138Lactobacillus_vaginalis_AF243177_264Bacteria_G4RPUYA02ENLBJ_Mycocepurus_529

0.240.240.240.240.240.230.230.230.230.230.570.570.570.570.57

Lactobacillus_frumenti_LSP250074_629X76329|g534948_Lactobacillus_pontis_037Bacteria_G4RPUYA02C1IZC_Mycocepurus_534

0.930.930.930.930.93

Lactobacillus_sp._Akhmro1_HM534768_309Lactobacillus_reuteri_F275_AP007281_062Lactobacillus_reuteri_F275_AP007281_c_063Lactobacillus_reuteri_F275_AP007281_n_064Lactobacillus_reuteri_F275_AP007281_f_065Lactobacillus_reuteri_F275_AP007281_q_066Lactobacillus_reuteri_F275_AP007281_i_067

0.880.880.880.880.88

uncultured_bacterium_EU791265_443uncultured_bacterium_EU791072_430Bacteria_G4RPUYA02EQ6U1_Mycocepurus_546

Bacteria_G4RPUYA02DJ8IV_Mycocepurus_533Bacteria_G4RPUYA02D2IM2_Mycocepurus_549

0.590.590.590.590.59

uncultured_bacterium_EU791134_438Bacteria_G4RPUYA02C82F5_Mycocepurus_513

Bacteria_G4RPUYA02C82QY_Mycocepurus_5450.690.690.690.690.690.510.510.510.510.51

0.050.050.050.050.050.410.410.410.410.41

0.930.930.930.930.93

Bacteria_G4RPUYA02C02W1_Mycocepurus_517Bacteria_G4RPUYA02C8GJU_Mycocepurus_520

Bacteria_G4RPUYA02DBPUF_Mycocepurus_522uncultured_bacterium_GQ175588_243

uncultured_bacterium_EU791181_247uncultured_bacterium_EU791159_440uncultured_bacterium_EU791116_439Bacteria_G4RPUYA02D4ZHO_Mycocepurus_550

0.440.440.440.440.44

AY239419_uncultured_bacterium_012Bacteria_G4RPUYA02DD4H3_Mycocepurus_544Bacteria_G4RPUYA02ECX6B_Mycocepurus_551

uncultured_bacterium_EU622700_459Bacteria_G4RPUYA02DAS3I_Mycocepurus_547

0.420.420.420.420.420.140.140.140.140.140.040.040.040.040.04

0.030.030.030.030.03

Bacteria_G2WUYFR01CFJ17_Solenopsis_579AE017198_Lactobacillus_johnsonii_NCC_533_006AE017198_Lactobacillus_johnsonii_NCC_533_007AE017198_Lactobacillus_johnsonii_NCC_533_008AE017198_Lactobacillus_johnsonii_NCC_533_009AE017198_Lactobacillus_johnsonii_NCC_533_010AE017198_Lactobacillus_johnsonii_NCC_533_011Lactobacillus_johnsonii_EU780913_140Bacteria_G4RPUYA02D066W_Mycocepurus_506Bacteria_G4RPUYA02DN9RG_Mycocepurus_515Bacteria_G4SXT0Z01BWJ7N_Solenopsis_582uncultured_bacterium_EU791127_442

Bacteria_G4RPUYA02DLV9U_Mycocepurus_521Bacteria_G4RPUYA02DCLGW_Mycocepurus_500

Bacteria_G4RPUYA02EL5KB_Mycocepurus_495Bacteria_G4RPUYA02EE9DE_Mycocepurus_527

0.780.780.780.780.780.280.280.280.280.280.110.110.110.110.11

0.060.060.060.060.06

Bacteria_G4RPUYA02DANKJ_Mycocepurus_519Bacteria_G4RPUYA02D9HKG_Mycocepurus_528Bacteria_G4RPUYA02C93MK_Mycocepurus_554Bacteria_G4RPUYA02C8Q5C_Mycocepurus_525Bacteria_G4RPUYA02DPY4I_Mycocepurus_532

0.540.540.540.540.540.210.210.210.210.210.170.170.170.170.17

Lactobacillus_taiwanensis_EU487512_084Lactobacillus_iatae_EF187258_137

0.410.410.410.410.41

Lactobacillus_gasseri_ATCC_33323_AF519171_618Lactobacillus_sp._61D_FR681902_426AY959035_uncultured_bacterium_004AY958891_uncultured_bacterium_005

uncultured_bacterium_EF653412_219uncultured_bacterium_AY959115_463

uncultured_bacterium_AY959095_241uncultured_bacterium_AY959163_436

uncultured_Firmicutes_bacterium_EF682866_049Lactobacillus_iners_Y16329_057uncultured_bacterium_AY959039_239

Bacteria_G4RPUYA02DE844_Mycocepurus_530Bacteria_G4RPUYA02EQ2ZF_Mycocepurus_537

0.160.160.160.160.160.650.650.650.650.65

0.200.200.200.200.200.360.360.360.360.36

0.400.400.400.400.40

Bacteria_G4RPUYA02D30I7_Mycocepurus_543Lactobacillus_crispatus_AJ242969_265

Bacteria_G4RPUYA02EGYQJ_Mycocepurus_492Bacteria_G4RPUYA02D6ETP_Mycocepurus_491

Bacteria_G4RPUYA02C254J_Mycocepurus_4970.740.740.740.740.74

Lactobacillus_GeEuPeBc0029_G1OJGBH03GSTGE_387Bacteria_G4RPUYA02C1VXY_Mycocepurus_510

Bacteria_G4RPUYA02C8GY8_Mycocepurus_507Bacteria_G4RPUYA02C8R7C_Mycocepurus_536

0.710.710.710.710.71

Bacteria_G4RPUYA02DNU3H_Mycocepurus_512Bacteria_G4RPUYA02D69JH_Mycocepurus_552

0.470.470.470.470.470.170.170.170.170.170.140.140.140.140.140.050.050.050.050.05

Bacteria_G4RPUYA02D481Y_Mycocepurus_524Lactobacillus_crispatus_EU559595_178Bacteria_G4RPUYA02C45QD_Mycocepurus_486Bacteria_G4RPUYA02D8UIL_Mycocepurus_548

0.940.940.940.940.940.130.130.130.130.13

Lactobacillus_crispatus_DQ317604_098Bacteria_G4RPUYA02C41OQ_Mycocepurus_502Bacteria_G4SXT0Z01B38UP_Solenopsis_584

0.960.960.960.960.960.460.460.460.460.46

uncultured_bacterium_AY958844_441Bacteria_G4RPUYA02DQ2EG_Mycocepurus_508

uncultured_bacterium_AY958858_054uncultured_bacterium_AY958900_201

0.880.880.880.880.880.640.640.640.640.64

uncultured_bacterium_DQ057433_465Lactobacillus_gallinarum_LGA417737_047

uncultured_bacterium_GQ267932_217Lactobacillus_acidophilus_EU878007_125Lactobacillus_helveticus_EU419585_221

0.840.840.840.840.840.340.340.340.340.340.090.090.090.090.090.150.150.150.150.15

M58802_Lactobacillus_acidophilus_003uncultured_bacterium_FJ880117_199

0.860.860.860.860.86

Lactobacillus_kitasatonis_AB186339_115Lactobacillus_acidophilus_AY773947_126

Bacteria_G4RPUYA02D8O9Y_Mycocepurus_5090.130.130.130.130.130.230.230.230.230.230.560.560.560.560.56

uncultured_bacterium_GQ267930_218uncultured_bacterium_GQ267866_229

Bacteria_G4RPUYA02DHIVZ_Mycocepurus_505Bacteria_G4RPUYA02DBPK8_Mycocepurus_511

0.510.510.510.510.510.090.090.090.090.09

uncultured_bacterium_DQ318873_421Bacteria_G4RPUYA02D2L56_Mycocepurus_480

0.550.550.550.550.55

Lactobacillaceae_bacterium_DJF_003_EU728746_101uncultured_bacterium_DQ318874_191

0.960.960.960.960.96

Lactobacillus_equicursoris_AB290830_116Lactobacillus_sp._66c_FR681900_427

1.001.001.001.001.00

M58823_Lactobacillus_delbrueckii_016Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_X_301Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_CV_302Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_CY_304Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_B_297Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_CC_299Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_S_305

0.050.050.050.050. 05

uncultured_bacterium_GQ267952_214Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_DJ_296Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_CK_300Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_BA_303

0.210.210.210.210.21

0.140.140.140.140.14

0.410.410.410.410.410.780.780.780.780.78

0.720.720.720.720.72

0.910.910.910.910.91

0.420.420.420.420.42

0.070.070.070.070.07

0.110.110.110.110.11

0.030.030.030.030.03

0.030.030.030.030.03

Lactobacillus_ultunensis_AY253660_159Lactobacillus_kefiranofaciens_subsp._kefiranofaciens_AM113781_630

0.360.360.360.360.36

uncultured_compost_bacterium_FN667084_212uncultured_Lactobacillus_sp._HM218856_458

Bacteria_G4RPUYA02DQODF_Mycocepurus_526Bacteria_G4RPUYA02C1VT3_Mycocepurus_535

0.690.690.690.690.690.350.350.350.350. 35

uncultured_Lactobacillus_sp._HM218874_085Bacteria_G4RPUYA02D1G4P_Mycocepurus_518

uncultured_Lactobacillus_sp._HM218864_193uncultured_Lactobacillus_sp._HM218878_451

1.001.001.001.001.000.280.280.280.280.280.230.230.230.230.23

0.070.070.070.070.070.060.060.060.060.06

uncultured_bacterium_FJ682870_232Bacteria_G2WUYFR01AP069_Solenopsis_571

0.570.570.570.570.57

uncultured_Lactobacillus_sp._HM218839_462Bacteria_G4SXT0Z01B6HAY_Solenopsis_563

0.070.070.070.070.07

Lactobacillus_amylovorus_GRL_1112_CP002338_A_161Lactobacillus_amylovorus_GRL_1112_CP002338_K_163Lactobacillus_amylovorus_GRL_1112_CP002338_AQ_164Lactobacillus_amylovorus_GRL_1112_CP002338_BQ_165Bacteria_G4RPUYA02ED17E_Mycocepurus_484uncultured_Lactobacillus_sp._HM218861_246

uncultured_Lactobacillus_sp._HM218863_4200.230.230.230.230.23

uncultured_Lactobacillus_sp._HM218833_460uncultured_Lactobacillus_sp._HM218869_461

0.880.880.880.880.88

uncultured_Lactobacillus_sp._HM218868_448uncultured_Lactobacillus_sp._HM218862_444uncultured_Lactobacillus_sp._HM218873_450

0.410.410.410.410.410.630.630.630.630.63

0.030.030.030.030.03

0.050.050.050.050.05

0.070.070.070.070.07

0.000.000.000.000.00

uncultured_Lactobacillus_sp._HM218837_086uncultured_bacterium_HM218871_194uncultured_bacterium_HM218855_195

0.610.610.610.610.610.570. 570.570.570.57

uncultured_bacterium_AY958851_055uncultured_bacterium_AY958918_422

Lactobacillus_psittaci_LPS272391_142Lactobacillus_jensenii_EU559601_171Lactobacillus_fornicalis_Y18654_619

0.960.960.960.960.960.650.650.650.650.650.410.410.410.410.41

0.660.660.660.660.660.050.050.050.050.05

Lactobacillus_hamsteri_LHA306298_104Lactobacillus_amylolyticus_DSM_11664_Y17361_263

0.660.660.660.660.66

uncultured_bacterium_HM218836_437Lactobacillus_gastricus_AY253657_230

Lactobacillus_intestinalis_LIN306299_100Lactobacillus_sp._ASF360_AF157050_273

uncultured_bacterium_AY239415_206uncultured_bacterium_AY239416_207

0.990.990.990.990.99

Lactobacillus_Q1_F7SSZP003GT0PR_336Lactobacillus_Q13_F7SSZP003GZ6SM_337

0.930.930.930.930.930.760.760.760.760.760.930.930.930.930.93

uncultured_Lactobacillus_sp._HM218872_429uncultured_Lactobacillus_sp._FJ192637_089

uncultured_bacterium_GU808381_200M58801_Lactobacillus_acetotolerans_020Lactobacillus_acetotolerans_FR683099_105

0.990.990.990.990.99

Bacteria_G2WUYFR01BBUKF_Solenopsis_605Lactobacillus_sp._Mbhsr5_HM534808_318Lactobacillus_sp._MbHmro1_HM534806_320

uncultured_Firmicutes_bacterium_HM215048_466Lactobacillus_sp._Adhmro12_HM534786_315Lactobacillus_sp._Afpor8_HM534796_322

0.350.350.350.350.350.050.050.050.050.05

Lactobacillus_sp._Afpoto13_HM534795_316Lactobacillus_sp._Aahonto7_HM534805_317

Firmicutes_bacterium_Bt_aa_02_AJ971929_293Lactobacillus_sp._Mardanium_GU233458_288

Lactobacillus_sp._Taj_KS164_GU233457_2900.990.990.990.990.99

uncultured_Lactobacillus_sp._HM113326_468uncultured_Lactobacillus_sp._HM046568_082uncultured_Lactobacillus_sp._HM046579_083

0.790.790.790.790.79

uncultured_Firmicutes_bacterium_DQ837634_469uncultured_Firmicutes_bacterium_DQ837635_471Bacteria_G2WUYFR01A2OJ0_Solenopsis_589

0.260.260.260.260.260.390.390.390.390.39

0.310.310.310.310.31

uncultured_Lactobacillus_sp._HM113281_154uncultured_Bacilli_bacterium_HM113257_425

0.540.540.540.540.54

uncultured_Lactobacillus_sp._AY370183_071uncultured_Firmicutes_bacterium_DQ837637_472

0.530.530.530.530.53

uncultured_Lactobacillus_sp._HM113333_151uncultured_Lactobacillus_sp._HM112866_153

0.290.290.290.290.29

uncultured_Lactobacillus_sp._HM112010_424Lactobacillus_alvei_AY667698_136Lactobacillus_sp._3b_EU753698_294

0.310.310.310.310.310.440.440.440.440.440.380.380.380.380.38

Lactobacillus_apis_AY667701_222Bacteria_G4SXT0Z01AYJLY_Solenopsis_587

0.890.890.890.890.89

uncultured_Lactobacillus_sp._HM113203_152Lactobacillus_insectis_AY667699_283

Lactobacillus_sp._B3_EU753697_292uncultured_Firmicutes_bacterium_DQ837636_470

0.540.540.540.540.540.470.470.470.470.47

0.190.190.190.190.19

0.260.260.260.260.26

0.450.450.450.450.45

0.300.300.300.300.30

0.040.040.040.040.04

0.000.000.000.000.000.030.030.030.030.03

0.390.390.390.390.39

0.330.330.330.330.330.360.360.360.360.36

0. 380.380.380.380.380.350.350.350.350.35

0.210.210.210.210.210.040.040.040.040.04

0.040.040.040.040.04

0.000.000.000.000.00

0.000.000.000.000.00

0.000.000.000.000.00

0.040.040.040.040.04

0.000.000.000.000.00

0.000.000.000.000.00

0.000.000.000.000.00

0.010.010.010.010.01

0.010.010.010.010.01

0.000.000.000.000.00

0.000.000.000.000.00

0.010.010.010.010.01

0.070.070.070.070.07

0.010.010.010.010.01

0.190.190.190.190.19

0. 050.050.050.050.05

0.060.060.060.060.06

0.070.070.070.070.070.050.050.050.050.050.070.070.070.070.070.030.030.030.030.03

0.000.000.000.000.00

0.000.000.000.000.00

0.000.000.000.000.00

0.010.010.010.010.01

0.070.070.070.070.07

0.110.110.110.110.110.070.070.070.070.07

0.380.380.380.380.38

0.070.070.070.070.07

0.040.040.040.040.04

0.030.030.030.030.03

0.040.040.040.040.04

0.040.040.040.040.04

0.060.060.060.060.06

0. 000.000.000.000.00

0.050.050.050.050.05

0.050.050.050.050.05

0.030.030.030.030.03

0.090.090.090.090.09

0.060.060.060.060.06

0.050.050.050.050.05

0.000.000.000.000.00

0.010.010.010.010.01

0.010.010.010.010.01

0.010.010.010.010.01

0.040.040.040.040.04

0.010.010.010.010.01

0.040.040.040.040.04

0.050.050.050.050.05

0.030.030.030.030.03

0.060.060.060.060.06

0.350.350.350.350.35

0.750.750.750.750.75

Firm3

Firm4

Fig. S2 B.

0.00.100.200.300.400.500.600.700.800.901.0

Pediococcus_pentosaceus_AB362987_053Bacteria_G2WUYFR02EYU2C_Solenopsis_608

0.530.530.530.530.53

uncultured_compost_bacterium_FN667076_208uncultured_bacterium_AF371496_213

0.780.780.780.780.78

Lactobacillus_senmaizukei_AB297927_414Lactobacillus_hammesii_AJ632219_043Lactobacillus_parabrevis_AM158249_095

Lactobacillus_sp._1.1424_FN185731_099uncultured_compost_bacterium_FN667298_211

0.590.590.590.590.590.590.590.590.590.590.090.090.090.090.090.360.360.360.360.36

Lactobacillus_brevis_ATCC_367_CP000416_f_177Bacteria_G2WUYFR02C9Q6O_Solenopsis_578

M58810_Lactobacillus_brevis_014X61134_Lactobacillus_brevis_013Bacteria_G2WUYFR01BA4B4_Solenopsis_564

0.410.410.410.410.41

Lactobacillus_brevis_ATCC_367_CP000416_o_176Lactobacillus_brevis_ATCC_367_CP000416_l_179Lactobacillus_brevis_ATCC_367_CP000416_c_174Lactobacillus_brevis_ATCC_367_CP000416_175

0.240.240.240.240.240.400.400.400.400.40

Bacteria_G2WUYFR02EUR0O_Solenopsis_574Bacteria_G2WUYFR01CAH48_Solenopsis_603

0.970.970.970.970.97

Lactobacillus_spicheri_LSP534844_059Lactobacillus_namurensis_AM259118_096

Lactobacillus_acidifarinae_AJ632158_093Lactobacillus_zymae_AJ632157_094

0.990.990.990.990.990.910.910.910.910.910.700.700.700.700.70

0.470.470.470.470.47

0.280.280.280.280.28

0.470.470.470.470.47

0.420.420.420.420.42

0.340.340.340.340.34

Lactobacillus_senioris_AB602570_298Lactobacillus_sp._Akporo7_HM534765_311

1.001.001.001.001.00

Lactobacillus_sp._JKD6_AF264701_614Lactobacillus_parafarraginis_AB262734_622

Lactobacillus_sp._r2_GQ247886_123M58821_Lactobacillus_hilgardii_017M59295_Lactobacillus_sp._034

0.440.440.440.440.440.950.950.950.950.95

Lactobacillus_farraginis_HM534766_139Lactobacillus_farraginis_AB262732_183Lactobacillus_faeni_AB362687_428

0.600.600.600.600.601.001.001.001.001.000.780.780.780.780.78

0.600.600.600.600.600.250.250.250.250.25

Lactobacillus_sp._NGRI_0130_AB362984_250Lactobacillus_rapi_AB366389_624

0.950.950.950.950.95

Lactobacillus_kisonensis_AB366388_628Lactobacillus_sp._rennanqilfy19_AY363377_237Lactobacillus_parabuchneri_AB205056_626

0.570.570.570.570.57

Lactobacillus_fermentum_FJ844993_130Lactobacillus_kefiri_AJ621553_135

1.001.001.001.001.00

Lactobacillus_otakiensis_AB366386_620Lactobacillus_sunkii_AB366385_625M58811_Lactobacillus_buchneri_015Lactobacillus_parakefiri_AY026750_612

0.860.860.860.860.860.400.400.400.400.400.380.380.380.380.380.640.640.640.640.640.840.840.840.840.840.510.510.510.510.510.510.510.510.510.51

0.820.820.820.820.82

0.890.890.890.890.89

Lactobacillus_ozensis_AB572588_051Lactobacillus_sp._MbBipro7_HM534743_313

0.960.960.960.960.96

uncultured_Bacilli_bacterium_HM112474_145uncultured_Lactobacillus_sp._HM008721_068

Lactobacillus_sp._Am_09_AJ971903_295Lactobacillus_kunkeei_AB559820_185Lactobacillus_kunkeei_EU753691_291

0.990.990.990.990.990.550.550.550.550.550.960.960.960.960.960.550.550.550.550.55

uncultured_Bacilli_bacterium_HM109480_143uncultured_Bacilli_bacterium_HM109610_144uncultured_Bacilli_bacterium_HM112778_146

0.990.990.990.990.99

uncultured_Bacilli_bacterium_HM112623_467Lactobacillus_Q7A_F348WMR04JBQ2M_333Lactobacillus_Q7A_F348WMR04JGOIJ_334

Lactobacillus_Q7A_F348WMR04IFQ7D_360Lactobacillus_Q7A_F348WMR04JDJG4_363

Lactobacillus_Q7A_F348WMR04JKTXT_340Lactobacillus_Q7A_F348WMR04JKJ8J_611

1.001.001.001.001.000.230.230.230.230.230.610.610.610.610.610.230.230.230.230.23

0.240.240.240.240.240.410.410.410.410.41

0.490.490.490.490.49

Lactobacillus_GeEuF1Bc0029_G1OJGBH03GX6IB_397Lactobacillus_GeEuF1Bc0029_G1OJGBH03G5C2A_398Lactobacillus_GeEuF1Bc0029_G1OJGBH03HAYWD_403

0.400.400.400.400.400.970.970.970.970.97

Lactobacillus_GeSoB2Bc0019_G1OJGBH03FWMY4_392Lactobacillus_GeSoB2Bc0019_G1OJGBH03GHBHU_382

Lactobacillus_GeSoB2Bc0019_G1OJGBH03FQASF_390Lactobacillus_GeEuB2Bc0029_G1OJGBH03G4ZG5_389Lactobacillus_GeEuA1Bc0029_G1OJGBH03GHVOY_407Lactobacillus_GeEuPeBc0029_G1OJGBH03FN2ZU_366Lactobacillus_GeEuF1Bc0029_G1OJGBH03GZEIB_379Lactobacillus_GeEuL2Bc0029_G1OJGBH03G5A0S_404Lactobacillus_GeEuB2Bc0029_G1OJGBH03F1OGP_372Lactobacillus_GeEuPeBc0029_G1OJGBH03G6R03_373Lactobacillus_GeEuL2Bc0029_G1OJGBH03F6ICY_393

0.260.260.260.260.26

Lactobacillus_GeSoL1Bc0019_G1OJGBH03GQQ4M_370Lactobacillus_GeEuPeBc0029_G1OJGBH03F3HKE_395

Lactobacillus_GeSoB2Bc0019_G1OJGBH03HCW2S_384Lactobacillus_GeEuB2Bc0029_G1OJGBH03FPP40_408

0.330.330.330.330.33

Lactobacillus_GeEuF1Bc0029_G1OJGBH03FKN70_385Lactobacillus_GeEuF1Bc0029_G1OJGBH03F5LSE_409

Lactobacillus_GeEuF1Bc0029_G1OJGBH03G4BBA_394Lactobacillus_GeEuF1Bc0029_G1OJGBH03GL6DL_400

0.400.400.400.400.400.550.550.550.550.550.310.310.310.310.31

0.070.070.070.070.07

0.010.010.010.010.010.040.040.040.040.040.030.030.030.030.03

0.100.100.100.100.10

0.390.390.390.390.39

0.130.130.130.130.130.160.160.160.160.16

0.330.330.330.330.33

0.360.360.360.360.36

0.360.360.360.360.36

Lactobacillus_sp._MbBipto3_HM534760_308Lactobacillus_sp._Mbhoto3_HM534763_310

1.001.001.001.001.00

X76330|g535112_Lactobacillus_fructivorans_028Lactobacillus_homohiochii_AJ621552_128

0.960.960.960.960.96

Lactobacillus_sp._Akhmbto4_HM534764_306Lactobacillus_florum_AB498047_048Lactobacillus_florum_AB498046_103

1.001.001.001.001.00

Lactobacillus_lindneri_X95421_252X61132_Lactobacillus_sanfrancisco_031X76327|g535106_Lactobacillus_sanfrancisco_032

1.001.001.001.001.000.860.860.860.860.860.820.820.820.820.82

1.001.001.001.001.000.930.930.930.930.93

Lactobacillus_Q13_F7SSZP003FI5FN_326Lactobacillus_Q13_F7SSZP003HFPEY_331Lactobacillus_Q13_F7SSZP003G5ZTS_349

Lactobacillus_Q1_F7SSZP003G3NEK_3520.790.790.790.790.790.190.190.190.190.19

0.230.230.230.230.23

Lactobacillus_Q1_F7SSZP003GUV9L_378Lactobacillus_Q11_F7SSZP003GTXXJ_354Lactobacillus_Q1_F7SSZP003GSQA4_329

Lactobacillus_Q1_F7SSZP003GRNEB_339Lactobacillus_Q1_F7SSZP003F337Q_327Lactobacillus_Q1_F7SSZP003HB7B3_332

0.560.560.560.560.560.360.360.360.360.36

Lactobacillus_Q11_F7SSZP003HHA6K_338Lactobacillus_Q1_F7SSZP003HBKSR_328

Lactobacillus_Q1_F7SSZP003HHGTB_3350.400.400.400.400.400.130.130.130.130.13

0.400.400.400.400.400.820.820.820.820.82

0.900.900.900.900.90

Lactobacillus_Q13_F7SSZP003FP9MZ_359Lactobacillus_Q1_F7SSZP003GZRYO_348

Lactobacillus_Q13_F7SSZP003GTPZN_375Lactobacillus_Q13_F7SSZP003FK90P_365Lactobacillus_Q1_F7SSZP003GVG3B_367

0.280.280.280.280.28

Lactobacillus_Q13_F7SSZP003FNTFE_361Lactobacillus_Q1_F7SSZP003G9G18_364

Lactobacillus_Q1_F7SSZP003FO813_3740.530.530.530.530.530.050.050.050.050.050.070.070.070.070.07

Lactobacillus_Q1_F7SSZP003F6H96_369Lactobacillus_Q13_F7SSZP003GLX8O_347

Lactobacillus_Q1_F7SSZP003HB207_344Lactobacillus_Q13_F7SSZP003GSJYU_350Lactobacillus_Q1_F7SSZP003G83HT_355Lactobacillus_Q1_F7SSZP003FQFVI_368

0.930.930.930.930.930.820.820.820.820.82

Lactobacillus_Q1_F7SSZP003FVDOE_343Lactobacillus_Q1_F7SSZP003GB27S_351

Lactobacillus_Q1_F7SSZP003FZBLV_345Lactobacillus_Q13_F7SSZP003HAPYQ_346

Lactobacillus_Q1_F7SSZP003FZDPQ_356Lactobacillus_Q1_F7SSZP003FJ41T_341

Lactobacillus_Q1_F7SSZP003FKU5E_3570.460.460.460.460.46

Lactobacillus_Q1_F7SSZP003FV2DK_342Lactobacillus_Q13_F7SSZP003GM303_371

0.130.130.130.130.130.030.030.030.030.03

0.010.010.010.010.010.090.090.090.090.09

0.030.030.030.030.030.000.000.000.000.000.050.050.050.050.05

0.060.060.060.060.060.070.070.070.070.07

0.070.070.070.070.070.050.050.050.050.05

0.040.040.040.040.04

0.030.030.030.030.03

0.060.060.060.060.06

0.070.070.070.070.07

0.200.200.200.200.20

0.630.630.630.630.63

0.300.300.300.300.30

0.260.260.260.260.26

0.390.390.390.390.39

0.310.310.310.310.31

0.070.070.070.070.07

0.060.060.060.060.06

0.010.010.010.010.01

0.010.010.010.010.01

Lactobacillus kunkeei clade

0.00.100.200.300.400.500.600.700.800.901.01.101.201.301.401.50

Carnobacterium_divergens_NR_044706_280Carnobacterium_maltaromaticum_NR_044710_281

0.720.720.720.720.72

Abiotrophia_defectiva_ATCC_49176_NR_025863_284Eremococcus_coleocola_NR_026481_287

1.001.001.001.001.000.970.970.970.970.97

Listeria_rocourtiae_FJ557241_056Bacillus_thuringiensis_str._Al_Hakam_CP000485_ag_069

Bacillus_coagulans_AF466695_2780.970.970.970.970.970.990.990.990.990.99

Enterococcus_moraviensis_NR_028794_279Enterococcus_hirae_NR_037082_272AY735408_Enterococcus_faecium_002Enterococcus_faecium_EF533987_092

1.001.001.001.001.000.970.970.970.970.970.990.990.990.990.99

Streptococcus_parasanguinis_ATCC_15912_NR_024842_275Lactococcus_lactis_subsp._lactis_KF147_NC_013656_BF_266Lactococcus_lactis_subsp._lactis_KF147_NC_013656_T_267Lactococcus_lactis_subsp._lactis_KF147_NC_013656_BQ_268Lactococcus_lactis_subsp._lactis_KF147_NC_013656_CB_269Lactococcus_lactis_subsp._lactis_KF147_NC_013656_CH_270Lactococcus_lactis_subsp._lactis_KF147_NC_013656_BM_271

1.001.001.001.001.001.001.001.001.001.00

0.680.680.680.680.68

0.680.680.680.680.68

0.400.400.400.400.40

Weissella_kandleri_NR_044659_274Bacteria_G2WUYFR02DPIHT_Solenopsis_590

0.640.640.640.640.64

M58809_Lactobacillus_bifermentans_025Lactobacillus_bifermentans_JN175330_205

Bacteria_G2WUYFR02DS0HK_Solenopsis_5551.001.001.001.001.00

Lactobacillus_backi_DQ406862_122M58813_Lactobacillus_coryniformis_026uncultured_bacterium_GQ479965_192

1.001.001.001.001.00

Lactobacillus_rennini_LSP576007_046Lactobacillus_halophilus_AB240455_081

1.001.001.001.001.000.790.790.790.790.79

0.800.800.800.800.800.990.990.990.990.99

Paralactobacillus_selangorensis_NR_024885_282Lactobacillus_algidus_AB033209_277Lactobacillus_satsumensis_AB362683_166Lactobacillus_oeni_EU821345_180

0.930.930.930.930.93

Lactobacillus_cacaonum_AM905389_079M58824_Lactobacillus_mali_029

Lactobacillus_hordei_EU074850_147Lactobacillus_mali_FJ157230_225

0.960.960.960.960.960.640.640.640.640.640.960.960.960.960.96

Lactobacillus_capillatus_AB365978_052Lactobacillus_sucicola_AB458681_087

0.570.570.570.570.57

Lactobacillus_uvarum_EU345000_075Lactobacillus_sp._IMCC1736_DQ664203_078

0.680.680.680.680.680.880.880.880.880.88

0.630.630.630.630.63

0.260.260.260.260.26

Lactobacillus_nagelii_AB162131_073Lactobacillus_ghanensis_DQ523489_133

1.001. 001.001.001.00

Lactobacillus_mobilis_AB242320_188uncultured_Lactobacillus_sp._HM218831_198

uncultured_Lactobacillus_sp._HM218848_097uncultured_Lactobacillus_sp._HM218858_445

1.001.001.001.001.001.001.001.001.001.000.860.860.860.860.86

0.900.900.900.900.90

M58807_Lactobacillus_animalis_024Lactobacillus_apodemi_AJ871178_070uncultured_bacterium_DQ075206_041Lactobacillus_murinus_AJ621554_134

uncultured_bacterium_DQ815470_203uncultured_bacterium_DQ815437_216

0.930.930.930.930.93

uncultured_bacterium_EU791129_449uncultured_bacterium_EU790976_453

0.820.820.820.820.82

Lactobacillus_Q2_F7SSZP003G8XXC_330uncultured_bacterium_EU791098_446

0.810.810.810.810.81

Lactobacillus_Q9_F7SSZP003GEOFA_358Lactobacillus_Q1_F7SSZP003G0JMG_353Lactobacillus_Q1_F7SSZP003FIY29_362

1.001.001.001.001.000.810.810.810.810.810.310.310.310.310.31

0.470.470.470.470.47

0.800.800.800.800.80

0.950.950.950.950.95

Lactobacillus_equi_AB425924_190Bacteria_G4RPUYA02C9XKQ_Mycocepurus_476

M58803_Lactobacillus_agilis_021uncultured_bacterium_AB559729_186

0.650.650.650.650.650.810.810.810.810.811.001.001.001.001. 00

Lactobacillus_sp._C33LV5_AF197125_262uncultured_bacterium_AB506300_187M58828_Lactobacillus_ruminis_030Lactobacillus_ruminis_AB326354_112

0.590.590.590.590.591.001.001.001.001.000.950.950.950.950.95

0.360.360.360.360.36

Lactobacillus_ceti_AM292799_150Lactobacillus_saerimneri_AY255802_227Lactobacillus_sp._MbBipro17_HM534774_325Lactobacillus_sp._Tporo2_HM534775_324Lactobacillus_pobuzihii_AB326365_111Lactobacillus_sp._MbBbr1_HM534771_321

Lactobacillus_sp._121B_AF305930_261Lactobacillus_acidipiscis_AB023836_617

0.630.630.630.630.630.450.450.450.450.450.800.800.800.800.80

0.650.650.650.650.651.001.001.001.001.00

Lactobacillus_hayakitensis_AB267406_118uncultured_bacterium_AY212750_418

1.001.001.001.001.00

Bacteria_G4RPUYA02EQEGE_Mycocepurus_494Lactobacillus_salivarius_AB186340_107Lactobacillus_salivarius_EU428010_141

Bacteria_G4RPUYA02DHK61_Mycocepurus_477uncultured_Lactobacillus_sp._AY672088_235Bacteria_G4RPUYA02DJDFD_Mycocepurus_489Bacteria_G4RPUYA02EYMBR_Mycocepurus_540

Bacteria_G2WUYFR01BYHUN_Solenopsis_557Bacteria_G4RPUYA02D1FDL_Mycocepurus_483

Bacteria_G4SXT0Z01B916P_Solenopsis_5650.330.330.330.330.330.720.720.720.720.72

0.240.240.240.240.24

0.190.190.190.190.190.710.710.710.710.71

0.590.590.590.590.59

Bacteria_G4RPUYA02DQ24F_Mycocepurus_487uncultured_bacterium_GU293196_197

Lactobacillus_intermedius_AB167386_090Bacteria_G2WUYFR02DBVUH_Solenopsis_606

0.510.510.510.510.510.230.230.230.230.23

Bacteria_G2WUYFR01AL9EQ_Solenopsis_576Lactobacillus_GeEuTuBc0029_G1OJGBH03GOLAZ_376Lactobacillus_aviarius_AB001837_276Bacteria_G4RPUYA02EBAXL_Mycocepurus_538

0.630.630.630.630.63

Bacteria_G4RPUYA02EALIM_Mycocepurus_479Bacteria_G4RPUYA02EECR6_Mycocepurus_478

Bacteria_G4RPUYA02DLZY4_Mycocepurus_542Bacteria_G4RPUYA02ECJZU_Mycocepurus_504Bacteria_G4RPUYA02DSRND_Mycocepurus_481

Bacteria_G4RPUYA02EHKZP_Mycocepurus_4820.460.460.460.460.46

Bacteria_G4RPUYA02EKHNN_Mycocepurus_490Bacteria_G4RPUYA02DOSON_Mycocepurus_485

Bacteria_G4RPUYA02C1C45_Mycocepurus_5230.240.240.240.240.240.100.100.100.100.100.140.140.140.140.14

Bacteria_G4RPUYA02DCJC6_Mycocepurus_501Bacteria_G4RPUYA02EGVOD_Mycocepurus_539

0.700.700.700.700.70

Bacteria_G4RPUYA02EDTH9_Mycocepurus_493Bacteria_G4RPUYA02D8Y4Y_Mycocepurus_499

Bacteria_G4RPUYA02DJDR6_Mycocepurus_5160.500.500.500.500.500.260.260.260.260.26

0.900.900.900.900.90

0.100.100.100.100.10

0.240.240.240.240.24

0.310.310.310.310.310.310.310.310.310.310.200.200.200.200.200.500.500.500.500.50

0.290.290.290.290.290.500.500.500.500.50

0.070.070.070.070.07

0.130.130.130.130.13

0.230.230.230.230.23

0.350.350.350.350.35

0.250.250.250.250.25

0.540.540.540.540.54

0.420.420.420.420.42

0.610.610.610.610.61

0.540.540.540.540.54

Lactobacillus_concavus_AY683322_076uncultured_bacterium_AM930364_456

1.001.001.001.001.00

Lactobacillus_dextrinicus_D87679_131uncultured_bacterium_AM500777_455

1.001.001.001.0 01.001.001.001.001.001.00

Lactobacillus_composti_AB268119_058Lactobacillus_perolens_Y19167_260

Lactobacillus_harbinensis_AB368915_129Lactobacillus_brevis_AY974809_168

0.990.990.990.990.991.001.001.001.001.000.450.450.450.450.45

Lactobacillus_floricola_AB523781_173Lactobacillus_sp._MbBipro19_HM534770_312

1.001.001.001.001.00

Lactobacillus_tucceti_LSP576006_181Lactobacillus_nodensis_AB332024_415

0.890.890.890.890.89

Lactobacillus_letivazi_AJ417738_257Lactobacillus_versmoldensis_AJ496791_256

uncultured_bacterium_AF371492_223Lactobacillus_nantensis_AY690834_627Lactobacillus_crustorum_FJ645924_184Lactobacillus_farciminis_AJ417499_254Lactobacillus_mindensis_LSP313530_050

M58804_Lactobacillus_alimentarius_022Lactobacillus_bobalius_AY681134_080

Lactobacillus_kimchii_AF183558_6150.500.500.500.500.500.960.960.960.960.96

0.550.550.550.550.550.330.330.330.330.330.960.960.960.960.96

1.001.001.001.001.000.290.290.290.290.29

0.380 .380.380.380.380.260.260.260.260.26

0.740.740.740.740.74

Lactobacillus_sp._Thmro15_HM534814_319uncultured_Lactobacillus_sp._HM113222_148

uncultured_Lactobacillus_sp._HM046576_088uncultured_Firmicutes_bacterium_DQ837632_286Lactobacillus_sp._F7_EU753690_289

0.820.820.820.820.821.001.001.001.001.000.720.720.720.720.72

0.540.540.540.540.54

Lactobacillus_sp._Adhmto19_HM534810_323uncultured_Lactobacillus_sp._HM112055_149

uncultured_Lactobacillus_sp._HM113158_2260.240.240.240.240.240.640.640.640.640.64

uncultured_Firmicutes_bacterium_HM215043_121uncultured_Firmicutes_bacterium_HM215041_119uncultured_Firmicutes_bacterium_HM215042_120

0.970.970.970.970.971.001.001.001.001.00

uncultured_Bacilli_bacterium_HM113258_155uncultured_Firmicutes_bacterium_DQ837631_473uncultured_Firmicutes_bacterium_DQ837630_474

1.001.001.001.001.000.860.860.860.860 .861.001.001.001.001.00

0.240.240.240.240.24

0.450.450.450.450.45

Lactobacillus_amylotrophicus_AM236149_114M58806_Lactobacillus_amylophilus_023uncultured_bacterium_AM500848_457

0.960.960.960.960.961.001.001.001.001.00

Bacteria_G2WUYFR01ALAWT_Solenopsis_575Bacteria_G2WUYFR02DXBGU_Solenopsis_561

Lactobacillus_sp._TS3_AB284946_102Bacteria_G2WUYFR01BMLOS_Solenopsis_568

Bacteria_G2WUYFR01AWLV8_Solenopsis_567Bacteria_G2WUYFR02EUU2R_Solenopsis_592

0.650.650.650.650.65

Bacteria_G2WUYFR02D8NSR_Solenopsis_588Bacteria_G2WUYFR01AY213_Solenopsis_609

0.810.810.810.810.81

Bacteria_G2WUYFR02D6JYS_Solenopsis_586Bacteria_G2WUYFR01B9IUO_Solenopsis_602

0.380.380.380.380.38

Bacteria_G2WUYFR02DYQIU_Solenopsis_591Bacteria_G2WUYFR01CEH5G_Solenopsis_599

0.750.750.750.750.750.380.380.380.380.38

0.280.280.280.280.28

0.340.340.340.340.340.210.210.210.210.21

0.330.330.330.330.330.750.750.750.750 .75

0.050.050.050.050.05

0.040.040.040.040.04

0.000.000.000.000.00

Lactobacillus_fuchuensis_AB370875_109Lactobacillus_graminis_AM113778_045Bacteria_G28NS4E02EPXZY_Solenopsis_583Lactobacillus_curvatus_AM113777_621

0.340.340.340.340.34

Lactobacillus_sakei_EU555174_224uncultured_bacterium_DQ922980_431

0.810.810.810.810.81

Bacteria_G2WUYFR01BCWHI_Solenopsis_580Bacteria_G2WUYFR01BEKHY_Solenopsis_562Bacteria_G2WUYFR01BNE8X_Solenopsis_596

0.360.360.360.360.36

Bacteria_G2WUYFR01BQJEU_Solenopsis_569Bacteria_G2WUYFR01B93S1_Solenopsis_597

0.200.200.200.200.200.510.510.510.510.510.140.140.140.140.14

0.170.170.170.170.170.500.500.500.500.50

0.860.860.860.860.86

Lactobacillus_thailandensis_AB257863_060Lactobacillus_pantheris_AB362679_172

0.990.990.990.990.99

uncultured_compost_bacterium_FN667294_204uncultured_bacterium_AF371503_244

M58831_Lactobacillus_sharpeae_033Bacteria_G2WUYFR02D4CBL_Solenopsis_581

0 .990.990.990.990.99

Lactobacillus_guizhouensis_GU138576_113Lactobacillus_guizhouensis_EF433578_124

0.500.500.500.500.500.960.960.960.960.96

0.910.910.910.910.910.340.340.340.340.34

0.740.740.740.740.74

Lactobacillus_camelliae_AB257864_074uncultured_bacterium_GQ477902_196

uncultured_bacterium_GQ477899_2400.780.780.780.780.780.970.970.970.970.97

Bacteria_G2WUYFR02D1R7T_Solenopsis_560uncultured_compost_bacterium_FN667075_209Lactobacillus_nasuensis_AB608051_412

1.001.001.001.001.000.300.300.300.300.30

Lactobacillus_manihotivorans_AF000163_259Bacteria_G2WUYFR02D23R9_Solenopsis_570

uncultured_compost_bacterium_FN667077_210Bacteria_G2WUYFR02DXNIT_Solenopsis_604

0.780.780.780.780.780.350.350.350.350.350.600.600.600.600.60

0.720.720.720.720.72

0.380.380.380.380.38

Lactobacillus_saniviri_AB602569_307Lactobacillus_sp._Akpobro1_HM534767_314

1.001.001.001.0 01.00

Lactobacillus_sp._LM_17_AJ132757_417Lactobacillus_rhamnosus_EU184020_170

Lactobacillus_sp._N3_1_1_AB379909_2490.850.850.850.850.850.260.260.260.260.26

Lactobacillus_zeae_D86516_613X61135_Lactobacillus_casei_039M23928_Lactobacillus_casei_040Bacteria_G4RPUYA02DO5UR_Mycocepurus_498Bacteria_G4RPUYA02DGY9G_Mycocepurus_503

Bacteria_G4RPUYA02C44TI_Mycocepurus_553

0.850.850.850.850.850.800.800.800.800.80

0.460.460.460.460.46

Lactobacillus_larvae_AY667700_464Lactobacillus_GeEuF1Bc0029_G1OJGBH03GBVJ2_383

Lactobacillus_GeEuL2Bc0029_G1OJGBH03FPFCW_399Lactobacillus_paracasei_AY773954_215

Lactobacillus_sp._N1_5_2_AB379908_2510.360.360.360.360.36

Lactobacillus_sp._N4_4_AB379912_452Bacteria_G2WUYFR02D35PT_Solenopsis_566

0.390.390.390.390.39

Lactobacillus_GeEuF1Bc0029_G1OJGBH03G7UHR_377Lactobacillus_GeEuF1Bc0029_G1OJGBH03HE4SG_381Lactobacillus_GeEuF1Bc0029_G1OJGBH03GD18U_386Lactobacillus_GeEuF1Bc0029_G1OJGBH03FXRZZ_396Lactobacillus_GeEuF1Bc0029_G1OJGBH03HA4AJ_401

0.680.680.680.680.680.300.300.300.300.300.130.130.130.130.13

0.130.130.130.130.13

0.190.190.190.190.19

0.060.060.060.060.06

0 .500.500.500.500.50

0.300.300.300.300.30

0.260.260.260.260.26

Pediococcus_pentosaceus_AB362987_053Bacteria_G2WUYFR02EYU2C_Solenopsis_608

0.530.530.530.530.53

uncultured_compost_bacterium_FN667076_208uncultured_bacterium_AF371496_213

0.780.780.780.780.78

Lactobacillus_senmaizukei_AB297927_414Lactobacillus_hammesii_AJ632219_043Lactobacillus_parabrevis_AM158249_095

Lactobacillus_sp._1.1424_FN185731_099uncultured_compost_bacterium_FN667298_211

0.590.590.590.590.590.590.590.590.590.590.090.090.090.090.090.360.360.360.360.36

Lactobacillus_brevis_ATCC_367_CP000416_f_177Bacteria_G2WUYFR02C9Q6O_Solenopsis_578

M58810_Lactobacillus_brevis_014X61134_Lactobacillus_brevis_013Bacteria_G2WUYFR01BA4B4_Solenopsis_564

0.410.410.410.410.41

Lactobacillus_brevis_ATCC_367_CP000416_o_176Lactobacillus_brevis_ATCC_367_CP000416_l_179Lactobacillus_brevis_ATCC_367_CP000416_c_174Lactobacillus_brevis_ATCC_367_CP000416_175

0.240.240.240.240.240.400.400.400.400.40

Bacteria_G2WUYFR02EUR0O_Solenopsis_574Bacteria_G2WUYFR01CAH48_Solenopsis_603

0.970.970.970.970.97

Lactobacillus_spicheri_LSP534844_059Lactobacillus_namurensis_AM259118_096

Lactobacillus_acidifarinae_AJ632158_093Lactobacillus_zymae_AJ632157_094

0.990.990.990.990.990.910.910.910.910.910.700.700.700.700.70

0.470.470.470.470.47

0.280.280.280.280.28

0.470.470.470.470.47

0.420.420.420.420.42

0.340.340.340.340.34

Lactobacillus_senioris_AB602570_298Lactobacillus_sp._Akporo7_HM534765_311

1.001.001.001.001.00

Lactobacillus_sp._JKD6_AF264701_614Lactobacillus_parafarraginis_AB262734_622

Lactobacillus_sp._r2_GQ247886_123M58821_Lactobacillus_hilgardii_017M59295_Lactobacillus_sp._034

0.440.440.440.440.440.950.950.950.950.95

Lactobacillus_farraginis_HM534766_139Lactobacillus_farraginis_AB262732_183Lactobacillus_faeni_AB362687_428

0.600.600.600.600.601.001.001.001.001.000.780.780.780.780.78

0.600.600.600.600.600.250.250 .250.250.25

Lactobacillus_sp._NGRI_0130_AB362984_250Lactobacillus_rapi_AB366389_624

0.950.950.950.950.95

Lactobacillus_kisonensis_AB366388_628Lactobacillus_sp._rennanqilfy19_AY363377_237Lactobacillus_parabuchneri_AB205056_626

0.570.570.570.570.57

Lactobacillus_fermentum_FJ844993_130Lactobacillus_kefiri_AJ621553_135

1.001.001.001.001.00

Lactobacillus_otakiensis_AB366386_620Lactobacillus_sunkii_AB366385_625M58811_Lactobacillus_buchneri_015Lactobacillus_parakefiri_AY026750_612

0.860.860.860.860.860.400.400.400.400.400.380.380.380.380.380.640.640.640.640.640.840.840.840.840.840.510.510.510.510.510.510.510.510.510.51

0.820.820.820.820.82

0.890.890.890.890.89

Lactobacillus_ozensis_AB572588_051Lactobacillus_sp._MbBipro7_HM534743_313

0.960.960.960.960.96

uncultured_Bacilli_bacterium_HM112474_145uncultured_Lactobacillus_sp._HM008721_068

Lactobacillus_sp._Am_09_AJ971903_295Lactobacillus_kunkeei_AB559820_185Lactobacillus_kunkeei_EU753691_291

0.990.990.990.990.990.550.550.550.550.550.960 .960.960.960.960.550.550.550.550.55

uncultured_Bacilli_bacterium_HM109480_143uncultured_Bacilli_bacterium_HM109610_144uncultured_Bacilli_bacterium_HM112778_146

0.990.990.990.990.99

uncultured_Bacilli_bacterium_HM112623_467Lactobacillus_Q7A_F348WMR04JBQ2M_333Lactobacillus_Q7A_F348WMR04JGOIJ_334

Lactobacillus_Q7A_F348WMR04IFQ7D_360Lactobacillus_Q7A_F348WMR04JDJG4_363

Lactobacillus_Q7A_F348WMR04JKTXT_340Lactobacillus_Q7A_F348WMR04JKJ8J_611

1.001.001.001.001.000.230.230.230.230.230.610.610.610.610.610.230.230.230.230.23

0.240.240.240.240.240.410.410.410.410.41

0.490.490.490.490.49

Lactobacillus_GeEuF1Bc0029_G1OJGBH03GX6IB_397Lactobacillus_GeEuF1Bc0029_G1OJGBH03G5C2A_398Lactobacillus_GeEuF1Bc0029_G1OJGBH03HAYWD_403

0.400.400.400.400.400.970.970.970.970.97

Lactobacillus_GeSoB2Bc0019_G1OJGBH03FWMY4_392Lactobacillus_GeSoB2Bc0019_G1OJGBH03GHBHU_382

Lactobacillus_GeSoB2Bc0019_G1OJGBH03FQASF_390Lactobacillus_GeEuB2Bc0029_G1OJGBH03G4ZG5_389Lactobacillus_GeEuA1Bc0029_G1OJGBH03GHVOY_407Lactobacillus_GeEuPeBc0029_G1OJGBH03FN2ZU_366Lactobacillus_GeEuF1Bc0029_G1OJGBH03GZEIB_379Lactobacillus_GeEuL2Bc0029_G1OJGBH03G5A0S_404Lactobacillus_GeEuB2Bc0029_G1OJGBH03F1OGP_372Lactobacillus_GeEuPeBc0029_G1OJGBH03G6R03_373Lactobacillus_GeEuL2Bc0029_G1OJGBH03F6ICY_393

0.260.260.260.260.26

Lactobacillus_GeSoL1Bc0019_G1OJGBH03GQQ4M_370Lactobacillus_GeEuPeBc0029_G1OJGBH03F3HKE_395

Lactobacillus_GeSoB2Bc0019_G1OJGBH03HCW2S_384Lactobacillus_GeEuB2Bc0029_G1OJGBH03FPP40_408

0.330.330.330.330.33

Lactobacillus_GeEuF1Bc0029_G1OJGBH03FKN70_385Lactobacillus_GeEuF1Bc0029_G1OJGBH03F5LSE_409

Lactobacillus_GeEuF1Bc0029_G1OJGBH03G4BBA_394Lactobacillus_GeEuF1Bc0029_G1OJGBH03GL6DL_400

0.400.400.400.400.400.550.550.550.550.550.310.310.310.310.31

0.070.070.070.070.07

0.010.010.010.010.010.040.040.040.040.040.030.030.030.030.03

0.100.100.100.100.10

0.390.390.390.390.39

0.130.130.130.130.130.160.160.160.160.16

0.330.330.330.330.33

0.360.360.360.360.36

0.360.360.360.360 .36

Lactobacillus_sp._MbBipto3_HM534760_308Lactobacillus_sp._Mbhoto3_HM534763_310

1.001.001.001.001.00

X76330|g535112_Lactobacillus_fructivorans_028Lactobacillus_homohiochii_AJ621552_128

0.960.960.960.960.96

Lactobacillus_sp._Akhmbto4_HM534764_306Lactobacillus_florum_AB498047_048Lactobacillus_florum_AB498046_103

1.001.001.001.001.00

Lactobacillus_lindneri_X95421_252X61132_Lactobacillus_sanfrancisco_031X76327|g535106_Lactobacillus_sanfrancisco_032

1.001.001.001.001.000.860.860.860.860.860.820.820.820.820.82

1.001.001.001.001.000.930.930.930.930.93

Lactobacillus_Q13_F7SSZP003FI5FN_326Lactobacillus_Q13_F7SSZP003HFPEY_331Lactobacillus_Q13_F7SSZP003G5ZTS_349

Lactobacillus_Q1_F7SSZP003G3NEK_3520.790.790.790.790.790.190.190.190.190.19

0.230.230.230.230.23

Lactobacillus_Q1_F7SSZP003GUV9L_378Lactobacillus_Q11_F7SSZP003GTXXJ_354Lactobacillus_Q1_F7SSZP003GSQA4_329

Lactobacillus_Q1_F7SSZP003GRNEB_339Lactobacillus_Q1_F7SSZP003F337Q_327Lactobacillus_Q1_F7SSZP003HB7B3_332

0.560.560.560.560.560.360.360.360.360.36

Lactobacillus_Q11_F7SSZP003HHA6K_338Lactobacillus_Q1_F7SSZP003HBKSR_328

Lactobacillus_Q1_F7SSZP003HHGTB_3350.400.400.400.400.400.130.130.130.1 30.13

0.400.400.400.400.400.820.820.820.820.82

0.900.900.900.900.90

Lactobacillus_Q13_F7SSZP003FP9MZ_359Lactobacillus_Q1_F7SSZP003GZRYO_348

Lactobacillus_Q13_F7SSZP003GTPZN_375Lactobacillus_Q13_F7SSZP003FK90P_365Lactobacillus_Q1_F7SSZP003GVG3B_367

0.280.280.280.280.28

Lactobacillus_Q13_F7SSZP003FNTFE_361Lactobacillus_Q1_F7SSZP003G9G18_364

Lactobacillus_Q1_F7SSZP003FO813_3740.530.530.530.530.530.050.050.050.050.050.070.070.070.070.07

Lactobacillus_Q1_F7SSZP003F6H96_369Lactobacillus_Q13_F7SSZP003GLX8O_347

Lactobacillus_Q1_F7SSZP003HB207_344Lactobacillus_Q13_F7SSZP003GSJYU_350Lactobacillus_Q1_F7SSZP003G83HT_355Lactobacillus_Q1_F7SSZP003FQFVI_368

0.930.930.930.930.930.820.820.820.820.82

Lactobacillus_Q1_F7SSZP003FVDOE_343Lactobacillus_Q1_F7SSZP003GB27S_351

Lactobacillus_Q1_F7SSZP003FZBLV_345Lactobacillus_Q13_F7SSZP003HAPYQ_346

Lactobacillus_Q1_F7SSZP003FZDPQ_356Lactobacillus_Q1_F7SSZP003FJ41T_341

Lactobacillus_Q1_F7SSZP003FKU5E_3570.460.460.460.460.46

Lactobacillus_Q1_F7SSZP003FV2DK_342Lactobacillus_Q13_F7SSZP003GM303_371

0.130.130.130.130.130.030.030.030.030.03

0.010.010.010.010.010.090.090.090.090.09

0.030.030.030.030.030.000.0 00.000.000.000.050.050.050.050.05

0.060.060.060.060.060.070.070.070.070.07

0.070.070.070.070.070.050.050.050.050.05

0.040.040.040.040.04

0.030.030.030.030.03

0.060.060.060.060.06

0.070.070.070.070.07

0.200.200.200.200.20

0.630.630.630.630.63

0.300.300.300.300.30

0.260.260.260.260.26

0.390.390.390.390.39

0.310.310.310.310.31

0.070.070.070.070.07

0.060.060.060.060.06

Lactobacillus_malefermentans_AM113783_182Bacteria_G2WUYFR02DUYD5_Solenopsis_559

0.990.990.990.990.99

Lactobacillus_sp._DCY51_EU678893_106Bacteria_G2WUYFR02DN04P_Solenopsis_556

Lactobacillus_collinoides_AB005893_044Lactobacillus_paracollinoides_AB159218_167

1.001.001.001 .001.00

Lactobacillus_odoratitofui_AB365975_108Lactobacillus_similis_AB282889_077Bacteria_G2WUYFR02ERHIP_Solenopsis_600

0.640.640.640.640.640.460.460.460.460.460.540.540.540.540.54

0.510.510.510.510.510.740.740.740.740.74

0.800.800.800.800.80

uncultured_bacterium_AF371494_220Lactobacillus_GeEuF1Bc0029_G1OJGBH03F8WFB_405

Bacteria_G2WUYFR02DVW1P_Solenopsis_598Bacteria_G28NS4E02DMQ1E_Solenopsis_594

Bacteria_G2WUYFR02D1WHH_Solenopsis_572Bacteria_G2WUYFR02D5DLK_Solenopsis_607

0.880.880.880.880.880.200.200.200.200.20

Lactobacillus_fabifermentans_AM905388_072Lactobacillus_plantarum_FJ915797_245

Bacteria_G28NS4E02EJUZ3_Solenopsis_601Lactobacillus_plantarum_JN126052_160

Lactobacillus_japonicus_AB681817_411Bacteria_G28NS4E02C3G8Q_Solenopsis_577

Bacteria_G28NS4E02DIEI6_Solenopsis_5930.510.510.510.510.51

0.030.030.030.030.03

Lactobacillus_plantarum_AJ965482_127D79211_Lactobacillus_pentosus_018

Lactobacillus_plantarum_AM279758_2020.100.100.100.100.10

M58827_Lactobacillus_plantarum_019Lactobacillus_plantarum_FJ386491_169

0.240.240.240.240.24

Lactobacillus_plantarum_FN252881_447Lactobacillus_plantarum_AB371712_238

Bacteria_G2WUYFR02DYMES_Solenopsis_6100.760.760.760.760.760.300.300.300.300.30

Lactobacillus_plantarum_AB371714_248Bacteria_G4RPUYA02D9F7Z_Mycocepurus_531

Bacteria_G28NS4E02DQD3U_Solenopsis_5580.600.600.600.600.600.130.130.130.130.13

0.060.060.060.060.06

0.030.030.030.030.03

0.010.010.010.010.01

0.140.140.140.140.14

0.340.340.340.340.34

0.090.090.090.090.09

0.500.500.500.500.50

0.760.760.760.760.76

0.140.140.140.140.14

Lactobacillus_siliginis_AB370882_413Lactobacillus_rossiae_LSP564009_156Lactobacillus_rossiae_AM920328_061Bacteria_G4RPUYA02DO47R_Mycocepurus_541

0.590.590.590.590.59

Lactobacillus_GeEuF1Bc0029_G1OJGBH03GO5Q0_380Lactobacillus_GeEuF1Bc0029_G1OJGBH03HCYM0_388Lactobacillus_GeEuF1Bc0029_G1OJGBH03FYH6Y_406

Lactobacillus_GeEuF1Bc0029_G1OJGBH03G2VUK_391Lactobacillus_GeEuF1Bc0029_G1OJGBH03G2OEC_402

0.850.850.850.850.850.590.590.590.590.590.590.590.590.590.59

0.690.690.690.690.691.001.001.001.001.00

Lactobacillus_suebicus_LSU575744_162Lactobacillus_vaccinostercus_AB362691_419Bacteria_G2WUYFR02DYIH7_Solenopsis_573

1.001.001.001.001.000.970.970.970.970.97

Lactobacillus_oligofermentans_AY733084_110uncultured_bacterium_HQ716645_236

0.530.530.530.530.53

Bacteria_G2WUYFR02EJBF3_Solenopsis_595Bacteria_G4RPUYA02EP6UO_Mycocepurus_488

Bacteria_G4RPUYA02D4F5G_Mycocepurus_5140.910.910.910.910.910.610.610.610.610.61

0.990.990.990.990.99

0.840.840.840.840.84

Lactobacillus_equigenerosi_AB288050_091Lactobacillus_antri_AY253658_157

0.850.850.850.850.85

Lactobacillus_fermentum_AF522394_253Lactobacillus_fermentum_EF535257_234

Bacteria_G2WUYFR01A00YD_Solenopsis_585M58819_Lactobacillus_fermentum_027Lactobacillus_fermentum_GQ131191_132

0.460.460.460.460.460.190.190.190.190.19

1.001.001.001.001.000.750.750.750.750.75

Lactobacillus_sp._G24_AF197126_258Lactobacillus_mucosae_AF126738_616

1.001.001.001.001.00

Lactobacillus_alvi_HQ718585_410Lactobacillus_ingluviei_AF308147_255

Bacteria_G4RPUYA02D2F2O_Mycocepurus_4961. 001.001.001.001.000.760.760.760.760.76

Lactobacillus_sp._TMW_1.1309_AM279150_189uncultured_bacterium_AB559717_435Lactobacillus_coleohominis_AM113776_623

1.001.001.001.001.00

Lactobacillus_sp._oral_taxon_052_GQ422710_042X94230|g1313964_Lactobacillus_panis_038

uncultured_bacterium_GQ505032_4540.780.780.780.780.78

uncultured_bacterium_HM218875_432Lactobacillus_kalixensis_AY253659_158X94229|g1313963_Lactobacillus_oris_035uncultured_bacterium_AB559668_434

0.970.970.970.970.970.990.990.990.990.990.530.530.530.530.531.001.001.001.001.00

uncultured_bacterium_AY958911_433X61136_Lactobacillus_vaginalis_036

Lactobacillus_vaginalis_HM534769_138Lactobacillus_vaginalis_AF243177_264Bacteria_G4RPUYA02ENLBJ_Mycocepurus_529

0.240.240.240.240.240.230.230.230.230.230.570.570.570.570.57

Lactobacillus_frumenti_LSP250074_629X76329|g534948_Lactobacillus_pontis_037Bacteria_G4RPUYA02C1IZC_Mycocepurus_534

0.930.930.930.930.93

Lactobacillus_sp._Akhmro1_HM534768_309Lactobacillus_reuteri_F275_AP007281_062Lactobacillus_reuteri_F275_AP007281_c_063Lactobacillus_reuteri_F275_AP007281_n_064Lactobacillus_reuteri_F275_AP007281_f_065Lactobacillus_reuteri_F275_AP007281_q_066Lactobacillus_reuteri_F275_AP007281_i_067

0.880.880.880.880.88

uncultured_bacterium_EU791265_443uncultured_bacterium_EU791072_430Bacteria_G4RPUYA02EQ6U1_Mycocepurus_546

Bacteria_G4RPUYA02DJ8IV_Mycocepurus_533Bacteria_G4RPUYA02D2IM2_Mycocepurus_549

0.590.590.590.590.59

uncultured_bacterium_EU791134_438Bacteria_G4RPUYA02C82F5_Mycocepurus_513

Bacteria_G4RPUYA02C82QY_Mycocepurus_5450.690.690.690.690.690.510.510.510.510.51

0.050.050.050.050.050.410.410.410.410.41

0.930.930.930.930.93

Bacteria_G4RPUYA02C02W1_Mycocepurus_517Bacteria_G4RPUYA02C8GJU_Mycocepurus_520

Bacteria_G4RPUYA02DBPUF_Mycocepurus_522uncultured_bacterium_GQ175588_243

uncultured_bacterium_EU791181_247uncultured_bacterium_EU791159_440uncultured_bacterium_EU791116_439Bacteria_G4RPUYA02D4ZHO_Mycocepurus_550

0.440.440.440.440.44

AY239419_uncultured_bacterium_012Bacteria_G4RPUYA02DD4H3_Mycocepurus_544Bacteria_G4RPUYA02ECX6B_Mycocepurus_551

uncultured_bacterium_EU622700_459Bacteria_G4RPUYA02DAS3I_Mycocepurus_547

0.420.420.420.420.420.140.140.140.140.140.040.040.040.040.04

0.030.030.030.030.03

Bacteria_G2WUYFR01CFJ17_Solenopsis_579AE017198_Lactobacillus_johnsonii_NCC_533_006AE017198_Lactobacillus_johnsonii_NCC_533_007AE017198_Lactobacillus_johnsonii_NCC_533_008AE017198_Lactobacillus_johnsonii_NCC_533_009AE017198_Lactobacillus_johnsonii_NCC_533_010AE017198_Lactobacillus_johnsonii_NCC_533_011Lactobacillus_johnsonii_EU780913_140Bacteria_G4RPUYA02D066W_Mycocepurus_506Bacteria_G4RPUYA02DN9RG_Mycocepurus_515Bacteria_G4SXT0Z01BWJ7N_Solenopsis_582uncultured_bacterium_EU791127_442

Bacteria_G4RPUYA02DLV9U_Mycocepurus_521Bacteria_G4RPUYA02DCLGW_Mycocepurus_500

Bacteria_G4RPUYA02EL5KB_Mycocepurus_495Bacteria_G4RPUYA02EE9DE_Mycocepurus_527

0.780.780.780.780.780.280.280.280.280.280.110.110.110.110.11

0.060.060.060.060.06

Bacteria_G4RPUYA02DANKJ_Mycocepurus_519Bacteria_G4RPUYA02D9HKG_Mycocepurus_528Bacteria_G4RPUYA02C93MK_Mycocepurus_554Bacteria_G4RPUYA02C8Q5C_Mycocepurus_525Bacteria_G4RPUYA02DPY4I_Mycocepurus_532

0.540.540.540.540.540.210.210.210.210.210.170.170.170.170.17

Lactobacillus_taiwanensis_EU487512_084Lactobacillus_iatae_EF187258_137

0.410.410.410.410.41

Lactobacillus_gasseri_ATCC_33323_AF519171_618Lactobacillus_sp._61D_FR681902_426AY959035_uncultured_bacterium_004AY958891_uncultured_bacterium_005

uncultured_bacterium_EF653412_219uncultured_bacterium_AY959115_463

uncultured_bacterium_AY959095_241uncultured_bacterium_AY959163_436

uncultured_Firmicutes_bacterium_EF682866_049Lactobacillus_iners_Y16329_057uncultured_bacterium_AY959039_239

Bacteria_G4RPUYA02DE844_Mycocepurus_530Bacteria_G4RPUYA02EQ2ZF_Mycocepurus_537

0.160.160.160.160.160.650.650.650.650.65

0.200.200.200.200.200.360.360.360.360.36

0.400.400.400.400.40

Bacteria_G4RPUYA02D30I7_Mycocepurus_543Lactobacillus_crispatus_AJ242969_265

Bacteria_G4RPUYA02EGYQJ_Mycocepurus_492Bacteria_G4RPUYA02D6ETP_Mycocepurus_491

Bacteria_G4RPUYA02C254J_Mycocepurus_4970.740.740.740.740.74

Lactobacillus_GeEuPeBc0029_G1OJGBH03GSTGE_387Bacteria_G4RPUYA02C1VXY_Mycocepurus_510

Bacteria_G4RPUYA02C8GY8_Mycocepurus_507Bacteria_G4RPUYA02C8R7C_Mycocepurus_536

0.710.710.710.710.71

Bacteria_G4RPUYA02DNU3H_Mycocepurus_512Bacteria_G4RPUYA02D69JH_Mycocepurus_552

0.470.470.470.470.470.170.170.170.170.170.140.140.140.140.140.050.050.050.050.05

Bacteria_G4RPUYA02D481Y_Mycocepurus_524Lactobacillus_crispatus_EU559595_178Bacteria_G4RPUYA02C45QD_Mycocepurus_486Bacteria_G4RPUYA02D8UIL_Mycocepurus_548

0.940.940.940.940.940.130.130.130.130.13

Lactobacillus_crispatus_DQ317604_098Bacteria_G4RPUYA02C41OQ_Mycocepurus_502Bacteria_G4SXT0Z01B38UP_Solenopsis_584

0.960.960.960.960.960.460.460.460.460.46

uncultured_bacterium_AY958844_441Bacteria_G4RPUYA02DQ2EG_Mycocepurus_508

uncultured_bacterium_AY958858_054uncultured_bacterium_AY958900_201

0.880.880.880.880.880.640.640.640.640.64

uncultured_bacterium_DQ057433_465Lactobacillus_gallinarum_LGA417737_047

uncultured_bacterium_GQ267932_217Lactobacillus_acidophilus_EU878007_125Lactobacillus_helveticus_EU419585_221

0.840.840.840.840.840.340.340.340.340.340.090.090.090.090.090.150.150.150.150.15

M58802_Lactobacillus_acidophilus_003uncultured_bacterium_FJ880117_199

0.860.860.860.860.86

Lactobacillus_kitasatonis_AB186339_115Lactobacillus_acidophilus_AY773947_126

Bacteria_G4RPUYA02D8O9Y_Mycocepurus_5090.130.130.130.130.130.230.230.230.230.230.560.560.560.560.56

uncultured_bacterium_GQ267930_218uncultured_bacterium_GQ267866_229

Bacteria_G4RPUYA02DHIVZ_Mycocepurus_505Bacteria_G4RPUYA02DBPK8_Mycocepurus_511

0.510.510.510.510.510.090.090.090.090.09

uncultured_bacterium_DQ318873_421Bacteria_G4RPUYA02D2L56_Mycocepurus_480

0.550.550.550.550.55

Lactobacillaceae_bacterium_DJF_003_EU728746_101uncultured_bacterium_DQ318874_191

0.960.960.960.960.96

Lactobacillus_equicursoris_AB290830_116Lactobacillus_sp._66c_FR681900_427

1.001.001.001.001.00

M58823_Lactobacillus_delbrueckii_016Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_X_301Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_CV_302Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_CY_304Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_B_297Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_CC_299Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_S_305

0.050.050.050.050. 05

uncultured_bacterium_GQ267952_214Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_DJ_296Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_CK_300Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_BA_303

0.210.210.210.210.21

0.140.140.140.140.14

0.410.410.410.410.410.780.780.780.780.78

0.720.720.720.720.72

0.910.910.910.910.91

0.420.420.420.420.42

0.070.070.070.070.07

0.110.110.110.110.11

0.030.030.030.030.03

0.030.030.030.030.03

Lactobacillus_ultunensis_AY253660_159Lactobacillus_kefiranofaciens_subsp._kefiranofaciens_AM113781_630

0.360.360.360.360.36

uncultured_compost_bacterium_FN667084_212uncultured_Lactobacillus_sp._HM218856_458

Bacteria_G4RPUYA02DQODF_Mycocepurus_526Bacteria_G4RPUYA02C1VT3_Mycocepurus_535

0.690.690.690.690.690.350.350.350.350. 35

uncultured_Lactobacillus_sp._HM218874_085Bacteria_G4RPUYA02D1G4P_Mycocepurus_518

uncultured_Lactobacillus_sp._HM218864_193uncultured_Lactobacillus_sp._HM218878_451

1.001.001.001.001.000.280.280.280.280.280.230.230.230.230.23

0.070.070.070.070.070.060.060.060.060.06

uncultured_bacterium_FJ682870_232Bacteria_G2WUYFR01AP069_Solenopsis_571

0.570.570.570.570.57

uncultured_Lactobacillus_sp._HM218839_462Bacteria_G4SXT0Z01B6HAY_Solenopsis_563

0.070.070.070.070.07

Lactobacillus_amylovorus_GRL_1112_CP002338_A_161Lactobacillus_amylovorus_GRL_1112_CP002338_K_163Lactobacillus_amylovorus_GRL_1112_CP002338_AQ_164Lactobacillus_amylovorus_GRL_1112_CP002338_BQ_165Bacteria_G4RPUYA02ED17E_Mycocepurus_484uncultured_Lactobacillus_sp._HM218861_246

uncultured_Lactobacillus_sp._HM218863_4200.230.230.230.230.23

uncultured_Lactobacillus_sp._HM218833_460uncultured_Lactobacillus_sp._HM218869_461

0.880.880.880.880.88

uncultured_Lactobacillus_sp._HM218868_448uncultured_Lactobacillus_sp._HM218862_444uncultured_Lactobacillus_sp._HM218873_450

0.410.410.410.410.410.630.630.630.630.63

0.030.030.030.030.03

0.050.050.050.050.05

0.070.070.070.070.07

0.000.000.000.000.00

uncultured_Lactobacillus_sp._HM218837_086uncultured_bacterium_HM218871_194uncultured_bacterium_HM218855_195

0.610.610.610.610.610.570. 570.570.570.57

uncultured_bacterium_AY958851_055uncultured_bacterium_AY958918_422

Lactobacillus_psittaci_LPS272391_142Lactobacillus_jensenii_EU559601_171Lactobacillus_fornicalis_Y18654_619

0.960.960.960.960.960.650.650.650.650.650.410.410.410.410.41

0.660.660.660.660.660.050.050.050.050.05

Lactobacillus_hamsteri_LHA306298_104Lactobacillus_amylolyticus_DSM_11664_Y17361_263

0.660.660.660.660.66

uncultured_bacterium_HM218836_437Lactobacillus_gastricus_AY253657_230

Lactobacillus_intestinalis_LIN306299_100Lactobacillus_sp._ASF360_AF157050_273

uncultured_bacterium_AY239415_206uncultured_bacterium_AY239416_207

0.990.990.990.990.99

Lactobacillus_Q1_F7SSZP003GT0PR_336Lactobacillus_Q13_F7SSZP003GZ6SM_337

0.930.930.930.930.930.760.760.760.760.760.930.930.930.930.93

uncultured_Lactobacillus_sp._HM218872_429uncultured_Lactobacillus_sp._FJ192637_089

uncultured_bacterium_GU808381_200M58801_Lactobacillus_acetotolerans_020Lactobacillus_acetotolerans_FR683099_105

0.990.990.990.990.99

Bacteria_G2WUYFR01BBUKF_Solenopsis_605Lactobacillus_sp._Mbhsr5_HM534808_318Lactobacillus_sp._MbHmro1_HM534806_320

uncultured_Firmicutes_bacterium_HM215048_466Lactobacillus_sp._Adhmro12_HM534786_315Lactobacillus_sp._Afpor8_HM534796_322

0.350.350.350.350.350.050.050.050.050.05

Lactobacillus_sp._Afpoto13_HM534795_316Lactobacillus_sp._Aahonto7_HM534805_317

Firmicutes_bacterium_Bt_aa_02_AJ971929_293Lactobacillus_sp._Mardanium_GU233458_288

Lactobacillus_sp._Taj_KS164_GU233457_2900.990.990.990.990.99

uncultured_Lactobacillus_sp._HM113326_468uncultured_Lactobacillus_sp._HM046568_082uncultured_Lactobacillus_sp._HM046579_083

0.790.790.790.790.79

uncultured_Firmicutes_bacterium_DQ837634_469uncultured_Firmicutes_bacterium_DQ837635_471Bacteria_G2WUYFR01A2OJ0_Solenopsis_589

0.260.260.260.260.260.390.390.390.390.39

0.310.310.310.310.31

uncultured_Lactobacillus_sp._HM113281_154uncultured_Bacilli_bacterium_HM113257_425

0.540.540.540.540.54

uncultured_Lactobacillus_sp._AY370183_071uncultured_Firmicutes_bacterium_DQ837637_472

0.530.530.530.530.53

uncultured_Lactobacillus_sp._HM113333_151uncultured_Lactobacillus_sp._HM112866_153

0.290.290.290.290.29

uncultured_Lactobacillus_sp._HM112010_424Lactobacillus_alvei_AY667698_136Lactobacillus_sp._3b_EU753698_294

0.310.310.310.310.310.440.440.440.440.440.380.380.380.380.38

Lactobacillus_apis_AY667701_222Bacteria_G4SXT0Z01AYJLY_Solenopsis_587

0.890.890.890.890.89

uncultured_Lactobacillus_sp._HM113203_152Lactobacillus_insectis_AY667699_283

Lactobacillus_sp._B3_EU753697_292uncultured_Firmicutes_bacterium_DQ837636_470

0.540.540.540.540.540.470.470.470.470.47

0.190.190.190.190.19

0.260.260.260.260.26

0.450.450.450.450.45

0.300.300.300.300.30

0.040.040.040.040.04

0.000.000.000.000.000.030.030.030.030.03

0.390.390.390.390.39

0.330.330.330.330.330.360.360.360.360.36

0. 380.380.380.380.380.350.350.350.350.35

0.210.210.210.210.210.040.040.040.040.04

0.040.040.040.040.04

0.000.000.000.000.00

0.000.000.000.000.00

0.000.000.000.000.00

0.040.040.040.040.04

0.000.000.000.000.00

0.000.000.000.000.00

0.000.000.000.000.00

0.010.010.010.010.01

0.010.010.010.010.01

0.000.000.000.000.00

0.000.000.000.000.00

0.010.010.010.010.01

0.070.070.070.070.07

0.010.010.010.010.01

0.190.190.190.190.19

0. 050.050.050.050.05

0.060.060.060.060.06

0.070.070.070.070.070.050.050.050.050.050.070.070.070.070.070.030.030.030.030.03

0.000.000.000.000.00

0.000.000.000.000.00

0.000.000.000.000.00

0.010.010.010.010.01

0.070.070.070.070.07

0.110.110.110.110.110.070.070.070.070.07

0.380.380.380.380.38

0.070.070.070.070.07

0.040.040.040.040.04

0.030.030.030.030.03

0.040.040.040.040.04

0.040.040.040.040.04

0.060.060.060.060.06

0. 000.000.000.000.00

0.050.050.050.050.05

0.050.050.050.050.05

0.030.030.030.030.03

0.090.090.090.090.09

0.060.060.060.060.06

0.050.050.050.050.05

0.000.000.000.000.00

0.010.010.010.010.01

0.010.010.010.010.01

0.010.010.010.010.01

0.040.040.040.040.04

0.010.010.010.010.01

0.040.040.040.040.04

0.050.050.050.050.05

0.030.030.030.030.03

0.060.060.060.060.06

0.350.350.350.350.35

0.750.750.750.750.75

Fig. S2 C.

Lactobacillus_malefermentans_AM113783_182Bacteria_G2WUYFR02DUYD5_Solenopsis_559

0.990.990.990.990.99

Lactobacillus_sp._DCY51_EU678893_106Bacteria_G2WUYFR02DN04P_Solenopsis_556

Lactobacillus_collinoides_AB005893_044Lactobacillus_paracollinoides_AB159218_167

1.001.001.001.001.00

Lactobacillus_odoratitofui_AB365975_108Lactobacillus_similis_AB282889_077Bacteria_G2WUYFR02ERHIP_Solenopsis_600

0.640.640.640.640.640.460.460.460.460.460.540.540.540.540.54

0.510.510.510.510.510.740.740.740.740.74

0.800.800.800.800.80

uncultured_bacterium_AF371494_220Lactobacillus_GeEuF1Bc0029_G1OJGBH03F8WFB_405

Bacteria_G2WUYFR02DVW1P_Solenopsis_598Bacteria_G28NS4E02DMQ1E_Solenopsis_594

Bacteria_G2WUYFR02D1WHH_Solenopsis_572Bacteria_G2WUYFR02D5DLK_Solenopsis_607

0.880.880.880.880.880.200.200.200.200.20

Lactobacillus_fabifermentans_AM905388_072Lactobacillus_plantarum_FJ915797_245

Bacteria_G28NS4E02EJUZ3_Solenopsis_601Lactobacillus_plantarum_JN126052_160

Lactobacillus_japonicus_AB681817_411Bacteria_G28NS4E02C3G8Q_Solenopsis_577

Bacteria_G28NS4E02DIEI6_Solenopsis_5930.510.510.510.510.51

0.030.030.030.030.03

Lactobacillus_plantarum_AJ965482_127D79211_Lactobacillus_pentosus_018

Lactobacillus_plantarum_AM279758_2020.100.100.100.100.10

M58827_Lactobacillus_plantarum_019Lactobacillus_plantarum_FJ386491_169

0.240.240.240.240.24

Lactobacillus_plantarum_FN252881_447Lactobacillus_plantarum_AB371712_238

Bacteria_G2WUYFR02DYMES_Solenopsis_6100.760.760.760.760.760.300.300.300.300.30

Lactobacillus_plantarum_AB371714_248Bacteria_G4RPUYA02D9F7Z_Mycocepurus_531

Bacteria_G28NS4E02DQD3U_Solenopsis_5580.600.600.600.600.600.130.130.130.130.13

0.060.060.060.060.06

0.030.030.030.030.03

0.010.010.010.010.01

0.140.140.140.140.14

0.340.340.340.340.34

0.090.090.090.090.09

0.500.500.500.500.50

0.760.760.760.760.76

0.140.140.140.140.14

Lactobacillus_siliginis_AB370882_413Lactobacillus_rossiae_LSP564009_156Lactobacillus_rossiae_AM920328_061Bacteria_G4RPUYA02DO47R_Mycocepurus_541

0.590.590.590.590.59

Lactobacillus_GeEuF1Bc0029_G1OJGBH03GO5Q0_380Lactobacillus_GeEuF1Bc0029_G1OJGBH03HCYM0_388Lactobacillus_GeEuF1Bc0029_G1OJGBH03FYH6Y_406

Lactobacillus_GeEuF1Bc0029_G1OJGBH03G2VUK_391Lactobacillus_GeEuF1Bc0029_G1OJGBH03G2OEC_402

0.850.850.850.850.850.590.590.590.590.590.590.590.590.590.59

0.690.690.690.690.691.001.001.001.001.00

Lactobacillus_suebicus_LSU575744_162Lactobacillus_vaccinostercus_AB362691_419Bacteria_G2WUYFR02DYIH7_Solenopsis_573

1.001.001.001.001.000.970.970.970.970.97

Lactobacillus_oligofermentans_AY733084_110uncultured_bacterium_HQ716645_236

0.530.530.530.530.53

Bacteria_G2WUYFR02EJBF3_Solenopsis_595Bacteria_G4RPUYA02EP6UO_Mycocepurus_488

Bacteria_G4RPUYA02D4F5G_Mycocepurus_5140.910.910.910.910.910.610.610.610.610.61

0.990.990.990.990.99

0.840.840.840.840.84

Lactobacillus_equigenerosi_AB288050_091Lactobacillus_antri_AY253658_157

0.850.850.850.850.85

Lactobacillus_fermentum_AF522394_253Lactobacillus_fermentum_EF535257_234

Bacteria_G2WUYFR01A00YD_Solenopsis_585M58819_Lactobacillus_fermentum_027Lactobacillus_fermentum_GQ131191_132

0.460.460.460.460.460.190.190.190.190.19

1.001.001.001.001.000.750.750.750.750.75

Lactobacillus_sp._G24_AF197126_258Lactobacillus_mucosae_AF126738_616

1.001.001.001.001.00

Lactobacillus_alvi_HQ718585_410Lactobacillus_ingluviei_AF308147_255

Bacteria_G4RPUYA02D2F2O_Mycocepurus_4961.001.001.001.001.000.760.760.760.760.76

Lactobacillus_sp._TMW_1.1309_AM279150_189uncultured_bacterium_AB559717_435Lactobacillus_coleohominis_AM113776_623

1.001.001.001.001.00

Lactobacillus_sp._oral_taxon_052_GQ422710_042X94230|g1313964_Lactobacillus_panis_038

uncultured_bacterium_GQ505032_4540.780.780.780.780.78

uncultured_bacterium_HM218875_432Lactobacillus_kalixensis_AY253659_158X94229|g1313963_Lactobacillus_oris_035uncultured_bacterium_AB559668_434

0.970.970.970.970.970.990.990.990.990.990.530.530.530.530.531.001.001.001.001.00

uncultured_bacterium_AY958911_433X61136_Lactobacillus_vaginalis_036

Lactobacillus_vaginalis_HM534769_138Lactobacillus_vaginalis_AF243177_264Bacteria_G4RPUYA02ENLBJ_Mycocepurus_529

0.240.240.240.240.240.230.230.230.230.230.570.570.570.570.57

Lactobacillus_frumenti_LSP250074_629X76329|g534948_Lactobacillus_pontis_037Bacteria_G4RPUYA02C1IZC_Mycocepurus_534

0.930.930.930.930.93

Lactobacillus_sp._Akhmro1_HM534768_309Lactobacillus_reuteri_F275_AP007281_062Lactobacillus_reuteri_F275_AP007281_c_063Lactobacillus_reuteri_F275_AP007281_n_064Lactobacillus_reuteri_F275_AP007281_f_065Lactobacillus_reuteri_F275_AP007281_q_066Lactobacillus_reuteri_F275_AP007281_i_067

0.880.880.880.880.88

uncultured_bacterium_EU791265_443uncultured_bacterium_EU791072_430Bacteria_G4RPUYA02EQ6U1_Mycocepurus_546

Bacteria_G4RPUYA02DJ8IV_Mycocepurus_533Bacteria_G4RPUYA02D2IM2_Mycocepurus_549

0.590.590.590.590.59

uncultured_bacterium_EU791134_438Bacteria_G4RPUYA02C82F5_Mycocepurus_513

Bacteria_G4RPUYA02C82QY_Mycocepurus_5450.690.690.690.690.690.510.510.510.510.51

0.050.050.050.050.050.410.410.410.410.41

0.930.930.930.930.93

Bacteria_G4RPUYA02C02W1_Mycocepurus_517Bacteria_G4RPUYA02C8GJU_Mycocepurus_520

Bacteria_G4RPUYA02DBPUF_Mycocepurus_522uncultured_bacterium_GQ175588_243

uncultured_bacterium_EU791181_247uncultured_bacterium_EU791159_440uncultured_bacterium_EU791116_439Bacteria_G4RPUYA02D4ZHO_Mycocepurus_550

0.440.440.440.440.44

AY239419_uncultured_bacterium_012Bacteria_G4RPUYA02DD4H3_Mycocepurus_544Bacteria_G4RPUYA02ECX6B_Mycocepurus_551

uncultured_bacterium_EU622700_459Bacteria_G4RPUYA02DAS3I_Mycocepurus_547

0.420.420.420.420.420.140.140.140.140.140.040.040.040.040.04

0.030.030.030.030.03

Bacteria_G2WUYFR01CFJ17_Solenopsis_579AE017198_Lactobacillus_johnsonii_NCC_533_006AE017198_Lactobacillus_johnsonii_NCC_533_007AE017198_Lactobacillus_johnsonii_NCC_533_008AE017198_Lactobacillus_johnsonii_NCC_533_009AE017198_Lactobacillus_johnsonii_NCC_533_010AE017198_Lactobacillus_johnsonii_NCC_533_011Lactobacillus_johnsonii_EU780913_140Bacteria_G4RPUYA02D066W_Mycocepurus_506Bacteria_G4RPUYA02DN9RG_Mycocepurus_515Bacteria_G4SXT0Z01BWJ7N_Solenopsis_582uncultured_bacterium_EU791127_442

Bacteria_G4RPUYA02DLV9U_Mycocepurus_521Bacteria_G4RPUYA02DCLGW_Mycocepurus_500

Bacteria_G4RPUYA02EL5KB_Mycocepurus_495Bacteria_G4RPUYA02EE9DE_Mycocepurus_527

0.780.780.780.780.780.280.280.280.280.280.110.110.110.110.11

0.060.060.060.060.06

Bacteria_G4RPUYA02DANKJ_Mycocepurus_519Bacteria_G4RPUYA02D9HKG_Mycocepurus_528Bacteria_G4RPUYA02C93MK_Mycocepurus_554Bacteria_G4RPUYA02C8Q5C_Mycocepurus_525Bacteria_G4RPUYA02DPY4I_Mycocepurus_532

0.540.540.540.540.540.210.210.210.210.210.170.170.170.170.17

Lactobacillus_taiwanensis_EU487512_084Lactobacillus_iatae_EF187258_137

0.410.410.410.410.41

Lactobacillus_gasseri_ATCC_33323_AF519171_618Lactobacillus_sp._61D_FR681902_426AY959035_uncultured_bacterium_004AY958891_uncultured_bacterium_005

uncultured_bacterium_EF653412_219uncultured_bacterium_AY959115_463

uncultured_bacterium_AY959095_241uncultured_bacterium_AY959163_436

uncultured_Firmicutes_bacterium_EF682866_049Lactobacillus_iners_Y16329_057uncultured_bacterium_AY959039_239

Bacteria_G4RPUYA02DE844_Mycocepurus_530Bacteria_G4RPUYA02EQ2ZF_Mycocepurus_537

0.160.160.160.160.160.650.650.650.650.65

0.200.200.200.200.200.360.360.360.360.36

0.400.400.400.400.40

0.050.050.050.050.05

0.060.060.060.060.06

0.070.070.070.070.070.050.050.050.050.050.070.070.070.070.070.030.030.030.030.03

0.000.000.000.000.00

0.000.000.000.000.00

0.000.000.000.000.00

0.010.010.010.010.01

0.070.070.070.070.07

0.110.110.110.110.110.070.070.070.070.07

0.380.380.380.380.38

0.070.070.070.070.07

0.040.040.040.040.04

0.030.030.030.030.03

0.040.040.040.040.04

0.040.040.040.040.04

0.060.060.060.060.06

0.000.000.000.000.00

0.050.050.050.050.05

0.050.050.050.050.05

0.030.030.030.030.03

0.090.090.090.090.09

0.060.060.060.060.06

0.050.050.050.050.05

0.000.000.000.000.00

0.00.100.200.300.400.500.600.700.800.901.01.101.201.30

0.00.100.200.300.400.500.600.700.800.901.01.101.201.301.401.50

Carnobacterium_divergens_NR_044706_280Carnobacterium_maltaromaticum_NR_044710_281

0.720.720.720.720.72

Abiotrophia_defectiva_ATCC_49176_NR_025863_284Eremococcus_coleocola_NR_026481_287

1.001.001.001.001.000.970.970.970.970.97

Listeria_rocourtiae_FJ557241_056Bacillus_thuringiensis_str._Al_Hakam_CP000485_ag_069

Bacillus_coagulans_AF466695_2780.970.970.970.970.970.990.990.990.990.99

Enterococcus_moraviensis_NR_028794_279Enterococcus_hirae_NR_037082_272AY735408_Enterococcus_faecium_002Enterococcus_faecium_EF533987_092

1.001.001.001.001.000.970.970.970.970.970.990.990.990.990.99

Streptococcus_parasanguinis_ATCC_15912_NR_024842_275Lactococcus_lactis_subsp._lactis_KF147_NC_013656_BF_266Lactococcus_lactis_subsp._lactis_KF147_NC_013656_T_267Lactococcus_lactis_subsp._lactis_KF147_NC_013656_BQ_268Lactococcus_lactis_subsp._lactis_KF147_NC_013656_CB_269Lactococcus_lactis_subsp._lactis_KF147_NC_013656_CH_270Lactococcus_lactis_subsp._lactis_KF147_NC_013656_BM_271

1.001.001.001.001.001.001.001.001.001.00

0.680.680.680.680.68

0.680.680.680.680.68

0.400.400.400.400.40

Weissella_kandleri_NR_044659_274Bacteria_G2WUYFR02DPIHT_Solenopsis_590

0.640.640.640.640.64

M58809_Lactobacillus_bifermentans_025Lactobacillus_bifermentans_JN175330_205

Bacteria_G2WUYFR02DS0HK_Solenopsis_5551.001.001.001.001.00

Lactobacillus_backi_DQ406862_122M58813_Lactobacillus_coryniformis_026uncultured_bacterium_GQ479965_192

1.001.001.001.001.00

Lactobacillus_rennini_LSP576007_046Lactobacillus_halophilus_AB240455_081

1.001.001.001.001.000.790.790.790.790.79

0.800.800.800.800.800.990.990.990.990.99

Paralactobacillus_selangorensis_NR_024885_282Lactobacillus_algidus_AB033209_277Lactobacillus_satsumensis_AB362683_166Lactobacillus_oeni_EU821345_180

0.930.930.930.930.93

Lactobacillus_cacaonum_AM905389_079M58824_Lactobacillus_mali_029

Lactobacillus_hordei_EU074850_147Lactobacillus_mali_FJ157230_225

0.960.960.960.960.960.640.640.640.640.640.960.960.960.960.96

Lactobacillus_capillatus_AB365978_052Lactobacillus_sucicola_AB458681_087

0.570.570.570.570.57

Lactobacillus_uvarum_EU345000_075Lactobacillus_sp._IMCC1736_DQ664203_078

0.680.680.680.680.680.880.880.880.880.88

0.630.630.630.630.63

0.260.260.260.260.26

Lactobacillus_nagelii_AB162131_073Lactobacillus_ghanensis_DQ523489_133

1.001. 001.001.001.00

Lactobacillus_mobilis_AB242320_188uncultured_Lactobacillus_sp._HM218831_198

uncultured_Lactobacillus_sp._HM218848_097uncultured_Lactobacillus_sp._HM218858_445

1.001.001.001.001.001.001.001.001.001.000.860.860.860.860.86

0.900.900.900.900.90

M58807_Lactobacillus_animalis_024Lactobacillus_apodemi_AJ871178_070uncultured_bacterium_DQ075206_041Lactobacillus_murinus_AJ621554_134

uncultured_bacterium_DQ815470_203uncultured_bacterium_DQ815437_216

0.930.930.930.930.93

uncultured_bacterium_EU791129_449uncultured_bacterium_EU790976_453

0.820.820.820.820.82

Lactobacillus_Q2_F7SSZP003G8XXC_330uncultured_bacterium_EU791098_446

0.810.810.810.810.81

Lactobacillus_Q9_F7SSZP003GEOFA_358Lactobacillus_Q1_F7SSZP003G0JMG_353Lactobacillus_Q1_F7SSZP003FIY29_362

1.001.001.001.001.000.810.810.810.810.810.310.310.310.310.31

0.470.470.470.470.47

0.800.800.800.800.80

0.950.950.950.950.95

Lactobacillus_equi_AB425924_190Bacteria_G4RPUYA02C9XKQ_Mycocepurus_476

M58803_Lactobacillus_agilis_021uncultured_bacterium_AB559729_186

0.650.650.650.650.650.810.810.810.810.811.001.001.001.001. 00

Lactobacillus_sp._C33LV5_AF197125_262uncultured_bacterium_AB506300_187M58828_Lactobacillus_ruminis_030Lactobacillus_ruminis_AB326354_112

0.590.590.590.590.591.001.001.001.001.000.950.950.950.950.95

0.360.360.360.360.36

Lactobacillus_ceti_AM292799_150Lactobacillus_saerimneri_AY255802_227Lactobacillus_sp._MbBipro17_HM534774_325Lactobacillus_sp._Tporo2_HM534775_324Lactobacillus_pobuzihii_AB326365_111Lactobacillus_sp._MbBbr1_HM534771_321

Lactobacillus_sp._121B_AF305930_261Lactobacillus_acidipiscis_AB023836_617

0.630.630.630.630.630.450.450.450.450.450.800.800.800.800.80

0.650.650.650.650.651.001.001.001.001.00

Lactobacillus_hayakitensis_AB267406_118uncultured_bacterium_AY212750_418

1.001.001.001.001.00

Bacteria_G4RPUYA02EQEGE_Mycocepurus_494Lactobacillus_salivarius_AB186340_107Lactobacillus_salivarius_EU428010_141

Bacteria_G4RPUYA02DHK61_Mycocepurus_477uncultured_Lactobacillus_sp._AY672088_235Bacteria_G4RPUYA02DJDFD_Mycocepurus_489Bacteria_G4RPUYA02EYMBR_Mycocepurus_540

Bacteria_G2WUYFR01BYHUN_Solenopsis_557Bacteria_G4RPUYA02D1FDL_Mycocepurus_483

Bacteria_G4SXT0Z01B916P_Solenopsis_5650.330.330.330.330.330.720.720.720.720.72

0.240.240.240.240.24

0.190.190.190.190.190.710.710.710.710.71

0.590.590.590.590.59

Bacteria_G4RPUYA02DQ24F_Mycocepurus_487uncultured_bacterium_GU293196_197

Lactobacillus_intermedius_AB167386_090Bacteria_G2WUYFR02DBVUH_Solenopsis_606

0.510.510.510.510.510.230.230.230.230.23

Bacteria_G2WUYFR01AL9EQ_Solenopsis_576Lactobacillus_GeEuTuBc0029_G1OJGBH03GOLAZ_376Lactobacillus_aviarius_AB001837_276Bacteria_G4RPUYA02EBAXL_Mycocepurus_538

0.630.630.630.630.63

Bacteria_G4RPUYA02EALIM_Mycocepurus_479Bacteria_G4RPUYA02EECR6_Mycocepurus_478

Bacteria_G4RPUYA02DLZY4_Mycocepurus_542Bacteria_G4RPUYA02ECJZU_Mycocepurus_504Bacteria_G4RPUYA02DSRND_Mycocepurus_481

Bacteria_G4RPUYA02EHKZP_Mycocepurus_4820.460.460.460.460.46

Bacteria_G4RPUYA02EKHNN_Mycocepurus_490Bacteria_G4RPUYA02DOSON_Mycocepurus_485

Bacteria_G4RPUYA02C1C45_Mycocepurus_5230.240.240.240.240.240.100.100.100.100.100.140.140.140.140.14

Bacteria_G4RPUYA02DCJC6_Mycocepurus_501Bacteria_G4RPUYA02EGVOD_Mycocepurus_539

0.700.700.700.700.70

Bacteria_G4RPUYA02EDTH9_Mycocepurus_493Bacteria_G4RPUYA02D8Y4Y_Mycocepurus_499

Bacteria_G4RPUYA02DJDR6_Mycocepurus_5160.500.500.500.500.500.260.260.260.260.26

0.900.900.900.900.90

0.100.100.100.100.10

0.240.240.240.240.24

0.310.310.310.310.310.310.310.310.310.310.200.200.200.200.200.500.500.500.500.50

0.290.290.290.290.290.500.500.500.500.50

0.070.070.070.070.07

0.130.130.130.130.13

0.230.230.230.230.23

0.350.350.350.350.35

0.250.250.250.250.25

0.540.540.540.540.54

0.420.420.420.420.42

0.610.610.610.610.61

0.540.540.540.540.54

Lactobacillus_concavus_AY683322_076uncultured_bacterium_AM930364_456

1.001.001.001.001.00

Lactobacillus_dextrinicus_D87679_131uncultured_bacterium_AM500777_455

1.001.001.001.0 01.001.001.001.001.001.00

Lactobacillus_composti_AB268119_058Lactobacillus_perolens_Y19167_260

Lactobacillus_harbinensis_AB368915_129Lactobacillus_brevis_AY974809_168

0.990.990.990.990.991.001.001.001.001.000.450.450.450.450.45

Lactobacillus_floricola_AB523781_173Lactobacillus_sp._MbBipro19_HM534770_312

1.001.001.001.001.00

Lactobacillus_tucceti_LSP576006_181Lactobacillus_nodensis_AB332024_415

0.890.890.890.890.89

Lactobacillus_letivazi_AJ417738_257Lactobacillus_versmoldensis_AJ496791_256

uncultured_bacterium_AF371492_223Lactobacillus_nantensis_AY690834_627Lactobacillus_crustorum_FJ645924_184Lactobacillus_farciminis_AJ417499_254Lactobacillus_mindensis_LSP313530_050

M58804_Lactobacillus_alimentarius_022Lactobacillus_bobalius_AY681134_080

Lactobacillus_kimchii_AF183558_6150.500.500.500.500.500.960.960.960.960.96

0.550.550.550.550.550.330.330.330.330.330.960.960.960.960.96

1.001.001.001.001.000.290.290.290.290.29

0.380 .380.380.380.380.260.260.260.260.26

0.740.740.740.740.74

Lactobacillus_sp._Thmro15_HM534814_319uncultured_Lactobacillus_sp._HM113222_148

uncultured_Lactobacillus_sp._HM046576_088uncultured_Firmicutes_bacterium_DQ837632_286Lactobacillus_sp._F7_EU753690_289

0.820.820.820.820.821.001.001.001.001.000.720.720.720.720.72

0.540.540.540.540.54

Lactobacillus_sp._Adhmto19_HM534810_323uncultured_Lactobacillus_sp._HM112055_149

uncultured_Lactobacillus_sp._HM113158_2260.240.240.240.240.240.640.640.640.640.64

uncultured_Firmicutes_bacterium_HM215043_121uncultured_Firmicutes_bacterium_HM215041_119uncultured_Firmicutes_bacterium_HM215042_120

0.970.970.970.970.971.001.001.001.001.00

uncultured_Bacilli_bacterium_HM113258_155uncultured_Firmicutes_bacterium_DQ837631_473uncultured_Firmicutes_bacterium_DQ837630_474

1.001.001.001.001.000.860.860.860.860 .861.001.001.001.001.00

0.240.240.240.240.24

0.450.450.450.450.45

Lactobacillus_amylotrophicus_AM236149_114M58806_Lactobacillus_amylophilus_023uncultured_bacterium_AM500848_457

0.960.960.960.960.961.001.001.001.001.00

Bacteria_G2WUYFR01ALAWT_Solenopsis_575Bacteria_G2WUYFR02DXBGU_Solenopsis_561

Lactobacillus_sp._TS3_AB284946_102Bacteria_G2WUYFR01BMLOS_Solenopsis_568

Bacteria_G2WUYFR01AWLV8_Solenopsis_567Bacteria_G2WUYFR02EUU2R_Solenopsis_592

0.650.650.650.650.65

Bacteria_G2WUYFR02D8NSR_Solenopsis_588Bacteria_G2WUYFR01AY213_Solenopsis_609

0.810.810.810.810.81

Bacteria_G2WUYFR02D6JYS_Solenopsis_586Bacteria_G2WUYFR01B9IUO_Solenopsis_602

0.380.380.380.380.38

Bacteria_G2WUYFR02DYQIU_Solenopsis_591Bacteria_G2WUYFR01CEH5G_Solenopsis_599

0.750.750.750.750.750.380.380.380.380.38

0.280.280.280.280.28

0.340.340.340.340.340.210.210.210.210.21

0.330.330.330.330.330.750.750.750.750 .75

0.050.050.050.050.05

0.040.040.040.040.04

0.000.000.000.000.00

Lactobacillus_fuchuensis_AB370875_109Lactobacillus_graminis_AM113778_045Bacteria_G28NS4E02EPXZY_Solenopsis_583Lactobacillus_curvatus_AM113777_621

0.340.340.340.340.34

Lactobacillus_sakei_EU555174_224uncultured_bacterium_DQ922980_431

0.810.810.810.810.81

Bacteria_G2WUYFR01BCWHI_Solenopsis_580Bacteria_G2WUYFR01BEKHY_Solenopsis_562Bacteria_G2WUYFR01BNE8X_Solenopsis_596

0.360.360.360.360.36

Bacteria_G2WUYFR01BQJEU_Solenopsis_569Bacteria_G2WUYFR01B93S1_Solenopsis_597

0.200.200.200.200.200.510.510.510.510.510.140.140.140.140.14

0.170.170.170.170.170.500.500.500.500.50

0.860.860.860.860.86

Lactobacillus_thailandensis_AB257863_060Lactobacillus_pantheris_AB362679_172

0.990.990.990.990.99

uncultured_compost_bacterium_FN667294_204uncultured_bacterium_AF371503_244

M58831_Lactobacillus_sharpeae_033Bacteria_G2WUYFR02D4CBL_Solenopsis_581

0 .990.990.990.990.99

Lactobacillus_guizhouensis_GU138576_113Lactobacillus_guizhouensis_EF433578_124

0.500.500.500.500.500.960.960.960.960.96

0.910.910.910.910.910.340.340.340.340.34

0.740.740.740.740.74

Lactobacillus_camelliae_AB257864_074uncultured_bacterium_GQ477902_196

uncultured_bacterium_GQ477899_2400.780.780.780.780.780.970.970.970.970.97

Bacteria_G2WUYFR02D1R7T_Solenopsis_560uncultured_compost_bacterium_FN667075_209Lactobacillus_nasuensis_AB608051_412

1.001.001.001.001.000.300.300.300.300.30

Lactobacillus_manihotivorans_AF000163_259Bacteria_G2WUYFR02D23R9_Solenopsis_570

uncultured_compost_bacterium_FN667077_210Bacteria_G2WUYFR02DXNIT_Solenopsis_604

0.780.780.780.780.780.350.350.350.350.350.600.600.600.600.60

0.720.720.720.720.72

0.380.380.380.380.38

Lactobacillus_saniviri_AB602569_307Lactobacillus_sp._Akpobro1_HM534767_314

1.001.001.001.0 01.00

Lactobacillus_sp._LM_17_AJ132757_417Lactobacillus_rhamnosus_EU184020_170

Lactobacillus_sp._N3_1_1_AB379909_2490.850.850.850.850.850.260.260.260.260.26

Lactobacillus_zeae_D86516_613X61135_Lactobacillus_casei_039M23928_Lactobacillus_casei_040Bacteria_G4RPUYA02DO5UR_Mycocepurus_498Bacteria_G4RPUYA02DGY9G_Mycocepurus_503

Bacteria_G4RPUYA02C44TI_Mycocepurus_553

0.850.850.850.850.850.800.800.800.800.80

0.460.460.460.460.46

Lactobacillus_larvae_AY667700_464Lactobacillus_GeEuF1Bc0029_G1OJGBH03GBVJ2_383

Lactobacillus_GeEuL2Bc0029_G1OJGBH03FPFCW_399Lactobacillus_paracasei_AY773954_215

Lactobacillus_sp._N1_5_2_AB379908_2510.360.360.360.360.36

Lactobacillus_sp._N4_4_AB379912_452Bacteria_G2WUYFR02D35PT_Solenopsis_566

0.390.390.390.390.39

Lactobacillus_GeEuF1Bc0029_G1OJGBH03G7UHR_377Lactobacillus_GeEuF1Bc0029_G1OJGBH03HE4SG_381Lactobacillus_GeEuF1Bc0029_G1OJGBH03GD18U_386Lactobacillus_GeEuF1Bc0029_G1OJGBH03FXRZZ_396Lactobacillus_GeEuF1Bc0029_G1OJGBH03HA4AJ_401

0.680.680.680.680.680.300.300.300.300.300.130.130.130.130.13

0.130.130.130.130.13

0.190.190.190.190.19

0.060.060.060.060.06

0 .500.500.500.500.50

0.300.300.300.300.30

0.260.260.260.260.26

Pediococcus_pentosaceus_AB362987_053Bacteria_G2WUYFR02EYU2C_Solenopsis_608

0.530.530.530.530.53

uncultured_compost_bacterium_FN667076_208uncultured_bacterium_AF371496_213

0.780.780.780.780.78

Lactobacillus_senmaizukei_AB297927_414Lactobacillus_hammesii_AJ632219_043Lactobacillus_parabrevis_AM158249_095

Lactobacillus_sp._1.1424_FN185731_099uncultured_compost_bacterium_FN667298_211

0.590.590.590.590.590.590.590.590.590.590.090.090.090.090.090.360.360.360.360.36

Lactobacillus_brevis_ATCC_367_CP000416_f_177Bacteria_G2WUYFR02C9Q6O_Solenopsis_578

M58810_Lactobacillus_brevis_014X61134_Lactobacillus_brevis_013Bacteria_G2WUYFR01BA4B4_Solenopsis_564

0.410.410.410.410.41

Lactobacillus_brevis_ATCC_367_CP000416_o_176Lactobacillus_brevis_ATCC_367_CP000416_l_179Lactobacillus_brevis_ATCC_367_CP000416_c_174Lactobacillus_brevis_ATCC_367_CP000416_175

0.240.240.240.240.240.400.400.400.400.40

Bacteria_G2WUYFR02EUR0O_Solenopsis_574Bacteria_G2WUYFR01CAH48_Solenopsis_603

0.970.970.970.970.97

Lactobacillus_spicheri_LSP534844_059Lactobacillus_namurensis_AM259118_096

Lactobacillus_acidifarinae_AJ632158_093Lactobacillus_zymae_AJ632157_094

0.990.990.990.990.990.910.910.910.910.910.700.700.700.700.70

0.470.470.470.470.47

0.280.280.280.280.28

0.470.470.470.470.47

0.420.420.420.420.42

0.340.340.340.340.34

Lactobacillus_senioris_AB602570_298Lactobacillus_sp._Akporo7_HM534765_311

1.001.001.001.001.00

Lactobacillus_sp._JKD6_AF264701_614Lactobacillus_parafarraginis_AB262734_622

Lactobacillus_sp._r2_GQ247886_123M58821_Lactobacillus_hilgardii_017M59295_Lactobacillus_sp._034

0.440.440.440.440.440.950.950.950.950.95

Lactobacillus_farraginis_HM534766_139Lactobacillus_farraginis_AB262732_183Lactobacillus_faeni_AB362687_428

0.600.600.600.600.601.001.001.001.001.000.780.780.780.780.78

0.600.600.600.600.600.250.250 .250.250.25

Lactobacillus_sp._NGRI_0130_AB362984_250Lactobacillus_rapi_AB366389_624

0.950.950.950.950.95

Lactobacillus_kisonensis_AB366388_628Lactobacillus_sp._rennanqilfy19_AY363377_237Lactobacillus_parabuchneri_AB205056_626

0.570.570.570.570.57

Lactobacillus_fermentum_FJ844993_130Lactobacillus_kefiri_AJ621553_135

1.001.001.001.001.00

Lactobacillus_otakiensis_AB366386_620Lactobacillus_sunkii_AB366385_625M58811_Lactobacillus_buchneri_015Lactobacillus_parakefiri_AY026750_612

0.860.860.860.860.860.400.400.400.400.400.380.380.380.380.380.640.640.640.640.640.840.840.840.840.840.510.510.510.510.510.510.510.510.510.51

0.820.820.820.820.82

0.890.890.890.890.89

Lactobacillus_ozensis_AB572588_051Lactobacillus_sp._MbBipro7_HM534743_313

0.960.960.960.960.96

uncultured_Bacilli_bacterium_HM112474_145uncultured_Lactobacillus_sp._HM008721_068

Lactobacillus_sp._Am_09_AJ971903_295Lactobacillus_kunkeei_AB559820_185Lactobacillus_kunkeei_EU753691_291

0.990.990.990.990.990.550.550.550.550.550.960 .960.960.960.960.550.550.550.550.55

uncultured_Bacilli_bacterium_HM109480_143uncultured_Bacilli_bacterium_HM109610_144uncultured_Bacilli_bacterium_HM112778_146

0.990.990.990.990.99

uncultured_Bacilli_bacterium_HM112623_467Lactobacillus_Q7A_F348WMR04JBQ2M_333Lactobacillus_Q7A_F348WMR04JGOIJ_334

Lactobacillus_Q7A_F348WMR04IFQ7D_360Lactobacillus_Q7A_F348WMR04JDJG4_363

Lactobacillus_Q7A_F348WMR04JKTXT_340Lactobacillus_Q7A_F348WMR04JKJ8J_611

1.001.001.001.001.000.230.230.230.230.230.610.610.610.610.610.230.230.230.230.23

0.240.240.240.240.240.410.410.410.410.41

0.490.490.490.490.49

Lactobacillus_GeEuF1Bc0029_G1OJGBH03GX6IB_397Lactobacillus_GeEuF1Bc0029_G1OJGBH03G5C2A_398Lactobacillus_GeEuF1Bc0029_G1OJGBH03HAYWD_403

0.400.400.400.400.400.970.970.970.970.97

Lactobacillus_GeSoB2Bc0019_G1OJGBH03FWMY4_392Lactobacillus_GeSoB2Bc0019_G1OJGBH03GHBHU_382

Lactobacillus_GeSoB2Bc0019_G1OJGBH03FQASF_390Lactobacillus_GeEuB2Bc0029_G1OJGBH03G4ZG5_389Lactobacillus_GeEuA1Bc0029_G1OJGBH03GHVOY_407Lactobacillus_GeEuPeBc0029_G1OJGBH03FN2ZU_366Lactobacillus_GeEuF1Bc0029_G1OJGBH03GZEIB_379Lactobacillus_GeEuL2Bc0029_G1OJGBH03G5A0S_404Lactobacillus_GeEuB2Bc0029_G1OJGBH03F1OGP_372Lactobacillus_GeEuPeBc0029_G1OJGBH03G6R03_373Lactobacillus_GeEuL2Bc0029_G1OJGBH03F6ICY_393

0.260.260.260.260.26

Lactobacillus_GeSoL1Bc0019_G1OJGBH03GQQ4M_370Lactobacillus_GeEuPeBc0029_G1OJGBH03F3HKE_395

Lactobacillus_GeSoB2Bc0019_G1OJGBH03HCW2S_384Lactobacillus_GeEuB2Bc0029_G1OJGBH03FPP40_408

0.330.330.330.330.33

Lactobacillus_GeEuF1Bc0029_G1OJGBH03FKN70_385Lactobacillus_GeEuF1Bc0029_G1OJGBH03F5LSE_409

Lactobacillus_GeEuF1Bc0029_G1OJGBH03G4BBA_394Lactobacillus_GeEuF1Bc0029_G1OJGBH03GL6DL_400

0.400.400.400.400.400.550.550.550.550.550.310.310.310.310.31

0.070.070.070.070.07

0.010.010.010.010.010.040.040.040.040.040.030.030.030.030.03

0.100.100.100.100.10

0.390.390.390.390.39

0.130.130.130.130.130.160.160.160.160.16

0.330.330.330.330.33

0.360.360.360.360.36

0.360.360.360.360 .36

Lactobacillus_sp._MbBipto3_HM534760_308Lactobacillus_sp._Mbhoto3_HM534763_310

1.001.001.001.001.00

X76330|g535112_Lactobacillus_fructivorans_028Lactobacillus_homohiochii_AJ621552_128

0.960.960.960.960.96

Lactobacillus_sp._Akhmbto4_HM534764_306Lactobacillus_florum_AB498047_048Lactobacillus_florum_AB498046_103

1.001.001.001.001.00

Lactobacillus_lindneri_X95421_252X61132_Lactobacillus_sanfrancisco_031X76327|g535106_Lactobacillus_sanfrancisco_032

1.001.001.001.001.000.860.860.860.860.860.820.820.820.820.82

1.001.001.001.001.000.930.930.930.930.93

Lactobacillus_Q13_F7SSZP003FI5FN_326Lactobacillus_Q13_F7SSZP003HFPEY_331Lactobacillus_Q13_F7SSZP003G5ZTS_349

Lactobacillus_Q1_F7SSZP003G3NEK_3520.790.790.790.790.790.190.190.190.190.19

0.230.230.230.230.23

Lactobacillus_Q1_F7SSZP003GUV9L_378Lactobacillus_Q11_F7SSZP003GTXXJ_354Lactobacillus_Q1_F7SSZP003GSQA4_329

Lactobacillus_Q1_F7SSZP003GRNEB_339Lactobacillus_Q1_F7SSZP003F337Q_327Lactobacillus_Q1_F7SSZP003HB7B3_332

0.560.560.560.560.560.360.360.360.360.36

Lactobacillus_Q11_F7SSZP003HHA6K_338Lactobacillus_Q1_F7SSZP003HBKSR_328

Lactobacillus_Q1_F7SSZP003HHGTB_3350.400.400.400.400.400.130.130.130.1 30.13

0.400.400.400.400.400.820.820.820.820.82

0.900.900.900.900.90

Lactobacillus_Q13_F7SSZP003FP9MZ_359Lactobacillus_Q1_F7SSZP003GZRYO_348

Lactobacillus_Q13_F7SSZP003GTPZN_375Lactobacillus_Q13_F7SSZP003FK90P_365Lactobacillus_Q1_F7SSZP003GVG3B_367

0.280.280.280.280.28

Lactobacillus_Q13_F7SSZP003FNTFE_361Lactobacillus_Q1_F7SSZP003G9G18_364

Lactobacillus_Q1_F7SSZP003FO813_3740.530.530.530.530.530.050.050.050.050.050.070.070.070.070.07

Lactobacillus_Q1_F7SSZP003F6H96_369Lactobacillus_Q13_F7SSZP003GLX8O_347

Lactobacillus_Q1_F7SSZP003HB207_344Lactobacillus_Q13_F7SSZP003GSJYU_350Lactobacillus_Q1_F7SSZP003G83HT_355Lactobacillus_Q1_F7SSZP003FQFVI_368

0.930.930.930.930.930.820.820.820.820.82

Lactobacillus_Q1_F7SSZP003FVDOE_343Lactobacillus_Q1_F7SSZP003GB27S_351

Lactobacillus_Q1_F7SSZP003FZBLV_345Lactobacillus_Q13_F7SSZP003HAPYQ_346

Lactobacillus_Q1_F7SSZP003FZDPQ_356Lactobacillus_Q1_F7SSZP003FJ41T_341

Lactobacillus_Q1_F7SSZP003FKU5E_3570.460.460.460.460.46

Lactobacillus_Q1_F7SSZP003FV2DK_342Lactobacillus_Q13_F7SSZP003GM303_371

0.130.130.130.130.130.030.030.030.030.03

0.010.010.010.010.010.090.090.090.090.09

0.030.030.030.030.030.000.0 00.000.000.000.050.050.050.050.05

0.060.060.060.060.060.070.070.070.070.07

0.070.070.070.070.070.050.050.050.050.05

0.040.040.040.040.04

0.030.030.030.030.03

0.060.060.060.060.06

0.070.070.070.070.07

0.200.200.200.200.20

0.630.630.630.630.63

0.300.300.300.300.30

0.260.260.260.260.26

0.390.390.390.390.39

0.310.310.310.310.31

0.070.070.070.070.07

0.060.060.060.060.06

Lactobacillus_malefermentans_AM113783_182Bacteria_G2WUYFR02DUYD5_Solenopsis_559

0.990.990.990.990.99

Lactobacillus_sp._DCY51_EU678893_106Bacteria_G2WUYFR02DN04P_Solenopsis_556

Lactobacillus_collinoides_AB005893_044Lactobacillus_paracollinoides_AB159218_167

1.001.001.001 .001.00

Lactobacillus_odoratitofui_AB365975_108Lactobacillus_similis_AB282889_077Bacteria_G2WUYFR02ERHIP_Solenopsis_600

0.640.640.640.640.640.460.460.460.460.460.540.540.540.540.54

0.510.510.510.510.510.740.740.740.740.74

0.800.800.800.800.80

uncultured_bacterium_AF371494_220Lactobacillus_GeEuF1Bc0029_G1OJGBH03F8WFB_405

Bacteria_G2WUYFR02DVW1P_Solenopsis_598Bacteria_G28NS4E02DMQ1E_Solenopsis_594

Bacteria_G2WUYFR02D1WHH_Solenopsis_572Bacteria_G2WUYFR02D5DLK_Solenopsis_607

0.880.880.880.880.880.200.200.200.200.20

Lactobacillus_fabifermentans_AM905388_072Lactobacillus_plantarum_FJ915797_245

Bacteria_G28NS4E02EJUZ3_Solenopsis_601Lactobacillus_plantarum_JN126052_160

Lactobacillus_japonicus_AB681817_411Bacteria_G28NS4E02C3G8Q_Solenopsis_577

Bacteria_G28NS4E02DIEI6_Solenopsis_5930.510.510.510.510.51

0.030.030.030.030.03

Lactobacillus_plantarum_AJ965482_127D79211_Lactobacillus_pentosus_018

Lactobacillus_plantarum_AM279758_2020.100.100.100.100.10

M58827_Lactobacillus_plantarum_019Lactobacillus_plantarum_FJ386491_169

0.240.240.240.240.24

Lactobacillus_plantarum_FN252881_447Lactobacillus_plantarum_AB371712_238

Bacteria_G2WUYFR02DYMES_Solenopsis_6100.760.760.760.760.760.300.300.300.300.30

Lactobacillus_plantarum_AB371714_248Bacteria_G4RPUYA02D9F7Z_Mycocepurus_531

Bacteria_G28NS4E02DQD3U_Solenopsis_5580.600.600.600.600.600.130.130.130.130.13

0.060.060.060.060.06

0.030.030.030.030.03

0.010.010.010.010.01

0.140.140.140.140.14

0.340.340.340.340.34

0.090.090.090.090.09

0.500.500.500.500.50

0.760.760.760.760.76

0.140.140.140.140.14

Lactobacillus_siliginis_AB370882_413Lactobacillus_rossiae_LSP564009_156Lactobacillus_rossiae_AM920328_061Bacteria_G4RPUYA02DO47R_Mycocepurus_541

0.590.590.590.590.59

Lactobacillus_GeEuF1Bc0029_G1OJGBH03GO5Q0_380Lactobacillus_GeEuF1Bc0029_G1OJGBH03HCYM0_388Lactobacillus_GeEuF1Bc0029_G1OJGBH03FYH6Y_406

Lactobacillus_GeEuF1Bc0029_G1OJGBH03G2VUK_391Lactobacillus_GeEuF1Bc0029_G1OJGBH03G2OEC_402

0.850.850.850.850.850.590.590.590.590.590.590.590.590.590.59

0.690.690.690.690.691.001.001.001.001.00

Lactobacillus_suebicus_LSU575744_162Lactobacillus_vaccinostercus_AB362691_419Bacteria_G2WUYFR02DYIH7_Solenopsis_573

1.001.001.001.001.000.970.970.970.970.97

Lactobacillus_oligofermentans_AY733084_110uncultured_bacterium_HQ716645_236

0.530.530.530.530.53

Bacteria_G2WUYFR02EJBF3_Solenopsis_595Bacteria_G4RPUYA02EP6UO_Mycocepurus_488

Bacteria_G4RPUYA02D4F5G_Mycocepurus_5140.910.910.910.910.910.610.610.610.610.61

0.990.990.990.990.99

0.840.840.840.840.84

Lactobacillus_equigenerosi_AB288050_091Lactobacillus_antri_AY253658_157

0.850.850.850.850.85

Lactobacillus_fermentum_AF522394_253Lactobacillus_fermentum_EF535257_234

Bacteria_G2WUYFR01A00YD_Solenopsis_585M58819_Lactobacillus_fermentum_027Lactobacillus_fermentum_GQ131191_132

0.460.460.460.460.460.190.190.190.190.19

1.001.001.001.001.000.750.750.750.750.75

Lactobacillus_sp._G24_AF197126_258Lactobacillus_mucosae_AF126738_616

1.001.001.001.001.00

Lactobacillus_alvi_HQ718585_410Lactobacillus_ingluviei_AF308147_255

Bacteria_G4RPUYA02D2F2O_Mycocepurus_4961. 001.001.001.001.000.760.760.760.760.76

Lactobacillus_sp._TMW_1.1309_AM279150_189uncultured_bacterium_AB559717_435Lactobacillus_coleohominis_AM113776_623

1.001.001.001.001.00

Lactobacillus_sp._oral_taxon_052_GQ422710_042X94230|g1313964_Lactobacillus_panis_038

uncultured_bacterium_GQ505032_4540.780.780.780.780.78

uncultured_bacterium_HM218875_432Lactobacillus_kalixensis_AY253659_158X94229|g1313963_Lactobacillus_oris_035uncultured_bacterium_AB559668_434

0.970.970.970.970.970.990.990.990.990.990.530.530.530.530.531.001.001.001.001.00

uncultured_bacterium_AY958911_433X61136_Lactobacillus_vaginalis_036

Lactobacillus_vaginalis_HM534769_138Lactobacillus_vaginalis_AF243177_264Bacteria_G4RPUYA02ENLBJ_Mycocepurus_529

0.240.240.240.240.240.230.230.230.230.230.570.570.570.570.57

Lactobacillus_frumenti_LSP250074_629X76329|g534948_Lactobacillus_pontis_037Bacteria_G4RPUYA02C1IZC_Mycocepurus_534

0.930.930.930.930.93

Lactobacillus_sp._Akhmro1_HM534768_309Lactobacillus_reuteri_F275_AP007281_062Lactobacillus_reuteri_F275_AP007281_c_063Lactobacillus_reuteri_F275_AP007281_n_064Lactobacillus_reuteri_F275_AP007281_f_065Lactobacillus_reuteri_F275_AP007281_q_066Lactobacillus_reuteri_F275_AP007281_i_067

0.880.880.880.880.88

uncultured_bacterium_EU791265_443uncultured_bacterium_EU791072_430Bacteria_G4RPUYA02EQ6U1_Mycocepurus_546

Bacteria_G4RPUYA02DJ8IV_Mycocepurus_533Bacteria_G4RPUYA02D2IM2_Mycocepurus_549

0.590.590.590.590.59

uncultured_bacterium_EU791134_438Bacteria_G4RPUYA02C82F5_Mycocepurus_513

Bacteria_G4RPUYA02C82QY_Mycocepurus_5450.690.690.690.690.690.510.510.510.510.51

0.050.050.050.050.050.410.410.410.410.41

0.930.930.930.930.93

Bacteria_G4RPUYA02C02W1_Mycocepurus_517Bacteria_G4RPUYA02C8GJU_Mycocepurus_520

Bacteria_G4RPUYA02DBPUF_Mycocepurus_522uncultured_bacterium_GQ175588_243

uncultured_bacterium_EU791181_247uncultured_bacterium_EU791159_440uncultured_bacterium_EU791116_439Bacteria_G4RPUYA02D4ZHO_Mycocepurus_550

0.440.440.440.440.44

AY239419_uncultured_bacterium_012Bacteria_G4RPUYA02DD4H3_Mycocepurus_544Bacteria_G4RPUYA02ECX6B_Mycocepurus_551

uncultured_bacterium_EU622700_459Bacteria_G4RPUYA02DAS3I_Mycocepurus_547

0.420.420.420.420.420.140.140.140.140.140.040.040.040.040.04

0.030.030.030.030.03

Bacteria_G2WUYFR01CFJ17_Solenopsis_579AE017198_Lactobacillus_johnsonii_NCC_533_006AE017198_Lactobacillus_johnsonii_NCC_533_007AE017198_Lactobacillus_johnsonii_NCC_533_008AE017198_Lactobacillus_johnsonii_NCC_533_009AE017198_Lactobacillus_johnsonii_NCC_533_010AE017198_Lactobacillus_johnsonii_NCC_533_011Lactobacillus_johnsonii_EU780913_140Bacteria_G4RPUYA02D066W_Mycocepurus_506Bacteria_G4RPUYA02DN9RG_Mycocepurus_515Bacteria_G4SXT0Z01BWJ7N_Solenopsis_582uncultured_bacterium_EU791127_442

Bacteria_G4RPUYA02DLV9U_Mycocepurus_521Bacteria_G4RPUYA02DCLGW_Mycocepurus_500

Bacteria_G4RPUYA02EL5KB_Mycocepurus_495Bacteria_G4RPUYA02EE9DE_Mycocepurus_527

0.780.780.780.780.780.280.280.280.280.280.110.110.110.110.11

0.060.060.060.060.06

Bacteria_G4RPUYA02DANKJ_Mycocepurus_519Bacteria_G4RPUYA02D9HKG_Mycocepurus_528Bacteria_G4RPUYA02C93MK_Mycocepurus_554Bacteria_G4RPUYA02C8Q5C_Mycocepurus_525Bacteria_G4RPUYA02DPY4I_Mycocepurus_532

0.540.540.540.540.540.210.210.210.210.210.170.170.170.170.17

Lactobacillus_taiwanensis_EU487512_084Lactobacillus_iatae_EF187258_137

0.410.410.410.410.41

Lactobacillus_gasseri_ATCC_33323_AF519171_618Lactobacillus_sp._61D_FR681902_426AY959035_uncultured_bacterium_004AY958891_uncultured_bacterium_005

uncultured_bacterium_EF653412_219uncultured_bacterium_AY959115_463

uncultured_bacterium_AY959095_241uncultured_bacterium_AY959163_436

uncultured_Firmicutes_bacterium_EF682866_049Lactobacillus_iners_Y16329_057uncultured_bacterium_AY959039_239

Bacteria_G4RPUYA02DE844_Mycocepurus_530Bacteria_G4RPUYA02EQ2ZF_Mycocepurus_537

0.160.160.160.160.160.650.650.650.650.65

0.200.200.200.200.200.360.360.360.360.36

0.400.400.400.400.40

Bacteria_G4RPUYA02D30I7_Mycocepurus_543Lactobacillus_crispatus_AJ242969_265

Bacteria_G4RPUYA02EGYQJ_Mycocepurus_492Bacteria_G4RPUYA02D6ETP_Mycocepurus_491

Bacteria_G4RPUYA02C254J_Mycocepurus_4970.740.740.740.740.74

Lactobacillus_GeEuPeBc0029_G1OJGBH03GSTGE_387Bacteria_G4RPUYA02C1VXY_Mycocepurus_510

Bacteria_G4RPUYA02C8GY8_Mycocepurus_507Bacteria_G4RPUYA02C8R7C_Mycocepurus_536

0.710.710.710.710.71

Bacteria_G4RPUYA02DNU3H_Mycocepurus_512Bacteria_G4RPUYA02D69JH_Mycocepurus_552

0.470.470.470.470.470.170.170.170.170.170.140.140.140.140.140.050.050.050.050.05

Bacteria_G4RPUYA02D481Y_Mycocepurus_524Lactobacillus_crispatus_EU559595_178Bacteria_G4RPUYA02C45QD_Mycocepurus_486Bacteria_G4RPUYA02D8UIL_Mycocepurus_548

0.940.940.940.940.940.130.130.130.130.13

Lactobacillus_crispatus_DQ317604_098Bacteria_G4RPUYA02C41OQ_Mycocepurus_502Bacteria_G4SXT0Z01B38UP_Solenopsis_584

0.960.960.960.960.960.460.460.460.460.46

uncultured_bacterium_AY958844_441Bacteria_G4RPUYA02DQ2EG_Mycocepurus_508

uncultured_bacterium_AY958858_054uncultured_bacterium_AY958900_201

0.880.880.880.880.880.640.640.640.640.64

uncultured_bacterium_DQ057433_465Lactobacillus_gallinarum_LGA417737_047

uncultured_bacterium_GQ267932_217Lactobacillus_acidophilus_EU878007_125Lactobacillus_helveticus_EU419585_221

0.840.840.840.840.840.340.340.340.340.340.090.090.090.090.090.150.150.150.150.15

M58802_Lactobacillus_acidophilus_003uncultured_bacterium_FJ880117_199

0.860.860.860.860.86

Lactobacillus_kitasatonis_AB186339_115Lactobacillus_acidophilus_AY773947_126

Bacteria_G4RPUYA02D8O9Y_Mycocepurus_5090.130.130.130.130.130.230.230.230.230.230.560.560.560.560.56

uncultured_bacterium_GQ267930_218uncultured_bacterium_GQ267866_229

Bacteria_G4RPUYA02DHIVZ_Mycocepurus_505Bacteria_G4RPUYA02DBPK8_Mycocepurus_511

0.510.510.510.510.510.090.090.090.090.09

uncultured_bacterium_DQ318873_421Bacteria_G4RPUYA02D2L56_Mycocepurus_480

0.550.550.550.550.55

Lactobacillaceae_bacterium_DJF_003_EU728746_101uncultured_bacterium_DQ318874_191

0.960.960.960.960.96

Lactobacillus_equicursoris_AB290830_116Lactobacillus_sp._66c_FR681900_427

1.001.001.001.001.00

M58823_Lactobacillus_delbrueckii_016Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_X_301Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_CV_302Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_CY_304Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_B_297Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_CC_299Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_S_305

0.050.050.050.050. 05

uncultured_bacterium_GQ267952_214Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_DJ_296Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_CK_300Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_BA_303

0.210.210.210.210.21

0.140.140.140.140.14

0.410.410.410.410.410.780.780.780.780.78

0.720.720.720.720.72

0.910.910.910.910.91

0.420.420.420.420.42

0.070.070.070.070.07

0.110.110.110.110.11

0.030.030.030.030.03

0.030.030.030.030.03

Lactobacillus_ultunensis_AY253660_159Lactobacillus_kefiranofaciens_subsp._kefiranofaciens_AM113781_630

0.360.360.360.360.36

uncultured_compost_bacterium_FN667084_212uncultured_Lactobacillus_sp._HM218856_458

Bacteria_G4RPUYA02DQODF_Mycocepurus_526Bacteria_G4RPUYA02C1VT3_Mycocepurus_535

0.690.690.690.690.690.350.350.350.350. 35

uncultured_Lactobacillus_sp._HM218874_085Bacteria_G4RPUYA02D1G4P_Mycocepurus_518

uncultured_Lactobacillus_sp._HM218864_193uncultured_Lactobacillus_sp._HM218878_451

1.001.001.001.001.000.280.280.280.280.280.230.230.230.230.23

0.070.070.070.070.070.060.060.060.060.06

uncultured_bacterium_FJ682870_232Bacteria_G2WUYFR01AP069_Solenopsis_571

0.570.570.570.570.57

uncultured_Lactobacillus_sp._HM218839_462Bacteria_G4SXT0Z01B6HAY_Solenopsis_563

0.070.070.070.070.07

Lactobacillus_amylovorus_GRL_1112_CP002338_A_161Lactobacillus_amylovorus_GRL_1112_CP002338_K_163Lactobacillus_amylovorus_GRL_1112_CP002338_AQ_164Lactobacillus_amylovorus_GRL_1112_CP002338_BQ_165Bacteria_G4RPUYA02ED17E_Mycocepurus_484uncultured_Lactobacillus_sp._HM218861_246

uncultured_Lactobacillus_sp._HM218863_4200.230.230.230.230.23

uncultured_Lactobacillus_sp._HM218833_460uncultured_Lactobacillus_sp._HM218869_461

0.880.880.880.880.88

uncultured_Lactobacillus_sp._HM218868_448uncultured_Lactobacillus_sp._HM218862_444uncultured_Lactobacillus_sp._HM218873_450

0.410.410.410.410.410.630.630.630.630.63

0.030.030.030.030.03

0.050.050.050.050.05

0.070.070.070.070.07

0.000.000.000.000.00

uncultured_Lactobacillus_sp._HM218837_086uncultured_bacterium_HM218871_194uncultured_bacterium_HM218855_195

0.610.610.610.610.610.570. 570.570.570.57

uncultured_bacterium_AY958851_055uncultured_bacterium_AY958918_422

Lactobacillus_psittaci_LPS272391_142Lactobacillus_jensenii_EU559601_171Lactobacillus_fornicalis_Y18654_619

0.960.960.960.960.960.650.650.650.650.650.410.410.410.410.41

0.660.660.660.660.660.050.050.050.050.05

Lactobacillus_hamsteri_LHA306298_104Lactobacillus_amylolyticus_DSM_11664_Y17361_263

0.660.660.660.660.66

uncultured_bacterium_HM218836_437Lactobacillus_gastricus_AY253657_230

Lactobacillus_intestinalis_LIN306299_100Lactobacillus_sp._ASF360_AF157050_273

uncultured_bacterium_AY239415_206uncultured_bacterium_AY239416_207

0.990.990.990.990.99

Lactobacillus_Q1_F7SSZP003GT0PR_336Lactobacillus_Q13_F7SSZP003GZ6SM_337

0.930.930.930.930.930.760.760.760.760.760.930.930.930.930.93

uncultured_Lactobacillus_sp._HM218872_429uncultured_Lactobacillus_sp._FJ192637_089

uncultured_bacterium_GU808381_200M58801_Lactobacillus_acetotolerans_020Lactobacillus_acetotolerans_FR683099_105

0.990.990.990.990.99

Bacteria_G2WUYFR01BBUKF_Solenopsis_605Lactobacillus_sp._Mbhsr5_HM534808_318Lactobacillus_sp._MbHmro1_HM534806_320

uncultured_Firmicutes_bacterium_HM215048_466Lactobacillus_sp._Adhmro12_HM534786_315Lactobacillus_sp._Afpor8_HM534796_322

0.350.350.350.350.350.050.050.050.050.05

Lactobacillus_sp._Afpoto13_HM534795_316Lactobacillus_sp._Aahonto7_HM534805_317

Firmicutes_bacterium_Bt_aa_02_AJ971929_293Lactobacillus_sp._Mardanium_GU233458_288

Lactobacillus_sp._Taj_KS164_GU233457_2900.990.990.990.990.99

uncultured_Lactobacillus_sp._HM113326_468uncultured_Lactobacillus_sp._HM046568_082uncultured_Lactobacillus_sp._HM046579_083

0.790.790.790.790.79

uncultured_Firmicutes_bacterium_DQ837634_469uncultured_Firmicutes_bacterium_DQ837635_471Bacteria_G2WUYFR01A2OJ0_Solenopsis_589

0.260.260.260.260.260.390.390.390.390.39

0.310.310.310.310.31

uncultured_Lactobacillus_sp._HM113281_154uncultured_Bacilli_bacterium_HM113257_425

0.540.540.540.540.54

uncultured_Lactobacillus_sp._AY370183_071uncultured_Firmicutes_bacterium_DQ837637_472

0.530.530.530.530.53

uncultured_Lactobacillus_sp._HM113333_151uncultured_Lactobacillus_sp._HM112866_153

0.290.290.290.290.29

uncultured_Lactobacillus_sp._HM112010_424Lactobacillus_alvei_AY667698_136Lactobacillus_sp._3b_EU753698_294

0.310.310.310.310.310.440.440.440.440.440.380.380.380.380.38

Lactobacillus_apis_AY667701_222Bacteria_G4SXT0Z01AYJLY_Solenopsis_587

0.890.890.890.890.89

uncultured_Lactobacillus_sp._HM113203_152Lactobacillus_insectis_AY667699_283

Lactobacillus_sp._B3_EU753697_292uncultured_Firmicutes_bacterium_DQ837636_470

0.540.540.540.540.540.470.470.470.470.47

0.190.190.190.190.19

0.260.260.260.260.26

0.450.450.450.450.45

0.300.300.300.300.30

0.040.040.040.040.04

0.000.000.000.000.000.030.030.030.030.03

0.390.390.390.390.39

0.330.330.330.330.330.360.360.360.360.36

0. 380.380.380.380.380.350.350.350.350.35

0.210.210.210.210.210.040.040.040.040.04

0.040.040.040.040.04

0.000.000.000.000.00

0.000.000.000.000.00

0.000.000.000.000.00

0.040.040.040.040.04

0.000.000.000.000.00

0.000.000.000.000.00

0.000.000.000.000.00

0.010.010.010.010.01

0.010.010.010.010.01

0.000.000.000.000.00

0.000.000.000.000.00

0.010.010.010.010.01

0.070.070.070.070.07

0.010.010.010.010.01

0.190.190.190.190.19

0. 050.050.050.050.05

0.060.060.060.060.06

0.070.070.070.070.070.050.050.050.050.050.070.070.070.070.070.030.030.030.030.03

0.000.000.000.000.00

0.000.000.000.000.00

0.000.000.000.000.00

0.010.010.010.010.01

0.070.070.070.070.07

0.110.110.110.110.110.070.070.070.070.07

0.380.380.380.380.38

0.070.070.070.070.07

0.040.040.040.040.04

0.030.030.030.030.03

0.040.040.040.040.04

0.040.040.040.040.04

0.060.060.060.060.06

0. 000.000.000.000.00

0.050.050.050.050.05

0.050.050.050.050.05

0.030.030.030.030.03

0.090.090.090.090.09

0.060.060.060.060.06

0.050.050.050.050.05

0.000.000.000.000.00

0.010.010.010.010.01

0.010.010.010.010.01

0.010.010.010.010.01

0.040.040.040.040.04

0.010.010.010.010.01

0.040.040.040.040.04

0.050.050.050.050.05

0.030.030.030.030.03

0.060.060.060.060.06

0.350.350.350.350.35

0.750.750.750.750.75

Fig. S2 D.

Bacteria_G4RPUYA02D30I7_Mycocepurus_543Lactobacillus_crispatus_AJ242969_265

Bacteria_G4RPUYA02EGYQJ_Mycocepurus_492Bacteria_G4RPUYA02D6ETP_Mycocepurus_491

Bacteria_G4RPUYA02C254J_Mycocepurus_4970.740.740.740.740.74

Lactobacillus_GeEuPeBc0029_G1OJGBH03GSTGE_387Bacteria_G4RPUYA02C1VXY_Mycocepurus_510

Bacteria_G4RPUYA02C8GY8_Mycocepurus_507Bacteria_G4RPUYA02C8R7C_Mycocepurus_536

0.710.710.710.710.71

Bacteria_G4RPUYA02DNU3H_Mycocepurus_512Bacteria_G4RPUYA02D69JH_Mycocepurus_552

0.470.470.470.470.470.170.170.170.170.170.140.140.140.140.140.050.050.050.050.05

Bacteria_G4RPUYA02D481Y_Mycocepurus_524Lactobacillus_crispatus_EU559595_178Bacteria_G4RPUYA02C45QD_Mycocepurus_486Bacteria_G4RPUYA02D8UIL_Mycocepurus_548

0.940.940.940.940.940.130.130.130.130.13

Lactobacillus_crispatus_DQ317604_098Bacteria_G4RPUYA02C41OQ_Mycocepurus_502Bacteria_G4SXT0Z01B38UP_Solenopsis_584

0.960.960.960.960.960.460.460.460.460.46

uncultured_bacterium_AY958844_441Bacteria_G4RPUYA02DQ2EG_Mycocepurus_508

uncultured_bacterium_AY958858_054uncultured_bacterium_AY958900_201

0.880.880.880.880.880.640.640.640.640.64

uncultured_bacterium_DQ057433_465Lactobacillus_gallinarum_LGA417737_047

uncultured_bacterium_GQ267932_217Lactobacillus_acidophilus_EU878007_125Lactobacillus_helveticus_EU419585_221

0.840.840.840.840.840.340.340.340.340.340.090.090.090.090.090.150.150.150.150.15

M58802_Lactobacillus_acidophilus_003uncultured_bacterium_FJ880117_199

0.860.860.860.860.86

Lactobacillus_kitasatonis_AB186339_115Lactobacillus_acidophilus_AY773947_126

Bacteria_G4RPUYA02D8O9Y_Mycocepurus_5090.130.130.130.130.130.230.230.230.230.230.560.560.560.560.56

uncultured_bacterium_GQ267930_218uncultured_bacterium_GQ267866_229

Bacteria_G4RPUYA02DHIVZ_Mycocepurus_505Bacteria_G4RPUYA02DBPK8_Mycocepurus_511

0.510.510.510.510.510.090.090.090.090.09

uncultured_bacterium_DQ318873_421Bacteria_G4RPUYA02D2L56_Mycocepurus_480

0.550.550.550.550.55

Lactobacillaceae_bacterium_DJF_003_EU728746_101uncultured_bacterium_DQ318874_191

0.960.960.960.960.96

Lactobacillus_equicursoris_AB290830_116Lactobacillus_sp._66c_FR681900_427

1.001.001.001.001.00

M58823_Lactobacillus_delbrueckii_016Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_X_301Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_CV_302Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_CY_304Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_B_297Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_CC_299Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_S_305

0.050.050.050.050.05

uncultured_bacterium_GQ267952_214Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_DJ_296Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_CK_300Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_BA_303

0.210.210.210.210.21

0.140.140.140.140.14

0.410.410.410.410.410.780.780.780.780.78

0.720.720.720.720.72

0.910.910.910.910.91

0.420.420.420.420.42

0.070.070.070.070.07

0.110.110.110.110.11

0.030.030.030.030.03

0.030.030.030.030.03

Lactobacillus_ultunensis_AY253660_159Lactobacillus_kefiranofaciens_subsp._kefiranofaciens_AM113781_630

0.360.360.360.360.36

uncultured_compost_bacterium_FN667084_212uncultured_Lactobacillus_sp._HM218856_458

Bacteria_G4RPUYA02DQODF_Mycocepurus_526Bacteria_G4RPUYA02C1VT3_Mycocepurus_535

0.690.690.690.690.690.350.350.350.350.35

uncultured_Lactobacillus_sp._HM218874_085Bacteria_G4RPUYA02D1G4P_Mycocepurus_518

uncultured_Lactobacillus_sp._HM218864_193uncultured_Lactobacillus_sp._HM218878_451

1.001.001.001.001.000.280.280.280.280.280.230.230.230.230.23

0.070.070.070.070.070.060.060.060.060.06

uncultured_bacterium_FJ682870_232Bacteria_G2WUYFR01AP069_Solenopsis_571

0.570.570.570.570.57

uncultured_Lactobacillus_sp._HM218839_462Bacteria_G4SXT0Z01B6HAY_Solenopsis_563

0.070.070.070.070.07

Lactobacillus_amylovorus_GRL_1112_CP002338_A_161Lactobacillus_amylovorus_GRL_1112_CP002338_K_163Lactobacillus_amylovorus_GRL_1112_CP002338_AQ_164Lactobacillus_amylovorus_GRL_1112_CP002338_BQ_165Bacteria_G4RPUYA02ED17E_Mycocepurus_484uncultured_Lactobacillus_sp._HM218861_246

uncultured_Lactobacillus_sp._HM218863_4200.230.230.230.230.23

uncultured_Lactobacillus_sp._HM218833_460uncultured_Lactobacillus_sp._HM218869_461

0.880.880.880.880.88

uncultured_Lactobacillus_sp._HM218868_448uncultured_Lactobacillus_sp._HM218862_444uncultured_Lactobacillus_sp._HM218873_450

0.410.410.410.410.410.630.630.630.630.63

0.030.030.030.030.03

0.050.050.050.050.05

0.070.070.070.070.07

0.000.000.000.000.00

uncultured_Lactobacillus_sp._HM218837_086uncultured_bacterium_HM218871_194uncultured_bacterium_HM218855_195

0.610.610.610.610.610.570.570.570.570.57

uncultured_bacterium_AY958851_055uncultured_bacterium_AY958918_422

Lactobacillus_psittaci_LPS272391_142Lactobacillus_jensenii_EU559601_171Lactobacillus_fornicalis_Y18654_619

0.960.960.960.960.960.650.650.650.650.650.410.410.410.410.41

0.660.660.660.660.660.050.050.050.050.05

Lactobacillus_hamsteri_LHA306298_104Lactobacillus_amylolyticus_DSM_11664_Y17361_263

0.660.660.660.660.66

uncultured_bacterium_HM218836_437Lactobacillus_gastricus_AY253657_230

Lactobacillus_intestinalis_LIN306299_100Lactobacillus_sp._ASF360_AF157050_273

uncultured_bacterium_AY239415_206uncultured_bacterium_AY239416_207

0.990.990.990.990.99

Lactobacillus_Q1_F7SSZP003GT0PR_336Lactobacillus_Q13_F7SSZP003GZ6SM_337

0.930.930.930.930.930.760.760.760.760.760.930.930.930.930.93

uncultured_Lactobacillus_sp._HM218872_429uncultured_Lactobacillus_sp._FJ192637_089

uncultured_bacterium_GU808381_200M58801_Lactobacillus_acetotolerans_020Lactobacillus_acetotolerans_FR683099_105

0.990.990.990.990.99

Bacteria_G2WUYFR01BBUKF_Solenopsis_605Lactobacillus_sp._Mbhsr5_HM534808_318Lactobacillus_sp._MbHmro1_HM534806_320

uncultured_Firmicutes_bacterium_HM215048_466Lactobacillus_sp._Adhmro12_HM534786_315Lactobacillus_sp._Afpor8_HM534796_322

0.350.350.350.350.350.050.050.050.050.05

Lactobacillus_sp._Afpoto13_HM534795_316Lactobacillus_sp._Aahonto7_HM534805_317

Firmicutes_bacterium_Bt_aa_02_AJ971929_293Lactobacillus_sp._Mardanium_GU233458_288

Lactobacillus_sp._Taj_KS164_GU233457_2900.990.990.990.990.99

uncultured_Lactobacillus_sp._HM113326_468uncultured_Lactobacillus_sp._HM046568_082uncultured_Lactobacillus_sp._HM046579_083

0.790.790.790.790.79

uncultured_Firmicutes_bacterium_DQ837634_469uncultured_Firmicutes_bacterium_DQ837635_471Bacteria_G2WUYFR01A2OJ0_Solenopsis_589

0.260.260.260.260.260.390.390.390.390.39

0.310.310.310.310.31

uncultured_Lactobacillus_sp._HM113281_154uncultured_Bacilli_bacterium_HM113257_425

0.540.540.540.540.54

uncultured_Lactobacillus_sp._AY370183_071uncultured_Firmicutes_bacterium_DQ837637_472

0.530.530.530.530.53

uncultured_Lactobacillus_sp._HM113333_151uncultured_Lactobacillus_sp._HM112866_153

0.290.290.290.290.29

uncultured_Lactobacillus_sp._HM112010_424Lactobacillus_alvei_AY667698_136Lactobacillus_sp._3b_EU753698_294

0.310.310.310.310.310.440.440.440.440.440.380.380.380.380.38

Lactobacillus_apis_AY667701_222Bacteria_G4SXT0Z01AYJLY_Solenopsis_587

0.890.890.890.890.89

uncultured_Lactobacillus_sp._HM113203_152Lactobacillus_insectis_AY667699_283

Lactobacillus_sp._B3_EU753697_292uncultured_Firmicutes_bacterium_DQ837636_470

0.540.540.540.540.540.470.470.470.470.47

0.190.190.190.190.19

0.260.260.260.260.26

0.450.450.450.450.45

0.300.300.300.300.30

0.040.040.040.040.04

0.000.000.000.000.000.030.030.030.030.03

0.390.390.390.390.39

0.330.330.330.330.330.360.360.360.360.36

0.380.380.380.380.380.350.350.350.350.35

0.210.210.210.210.210.040.040.040.040.04

0.040.040.040.040.04

0.000.000.000.000.00

0.000.000.000.000.00

0.000.000.000.000.00

0.040.040.040.040.04

0.000.000.000.000.00

0.000.000.000.000.00

0.000.000.000.000.00

0.010.010.010.010.01

0.010.010.010.010.01

0.000.000.000.000.00

0.000.000.000.000.00

0.010.010.010.010.01

0.070.070.070.070.07

0.010.010.010.010.01

0.190.190.190.190.19

0.00.100.200.300.400.500.600.700.800.901.0

0.00.100.200.300.400.500.600.700.800.901.01.101.201.301.401.50

Carnobacterium_divergens_NR_044706_280Carnobacterium_maltaromaticum_NR_044710_281

0.720.720.720.720.72

Abiotrophia_defectiva_ATCC_49176_NR_025863_284Eremococcus_coleocola_NR_026481_287

1.001.001.001.001.000.970.970.970.970.97

Listeria_rocourtiae_FJ557241_056Bacillus_thuringiensis_str._Al_Hakam_CP000485_ag_069

Bacillus_coagulans_AF466695_2780.970.970.970.970.970.990.990.990.990.99

Enterococcus_moraviensis_NR_028794_279Enterococcus_hirae_NR_037082_272AY735408_Enterococcus_faecium_002Enterococcus_faecium_EF533987_092

1.001.001.001.001.000.970.970.970.970.970.990.990.990.990.99

Streptococcus_parasanguinis_ATCC_15912_NR_024842_275Lactococcus_lactis_subsp._lactis_KF147_NC_013656_BF_266Lactococcus_lactis_subsp._lactis_KF147_NC_013656_T_267Lactococcus_lactis_subsp._lactis_KF147_NC_013656_BQ_268Lactococcus_lactis_subsp._lactis_KF147_NC_013656_CB_269Lactococcus_lactis_subsp._lactis_KF147_NC_013656_CH_270Lactococcus_lactis_subsp._lactis_KF147_NC_013656_BM_271

1.001.001.001.001.001.001.001.001.001.00

0.680.680.680.680.68

0.680.680.680.680.68

0.400.400.400.400.40

Weissella_kandleri_NR_044659_274Bacteria_G2WUYFR02DPIHT_Solenopsis_590

0.640.640.640.640.64

M58809_Lactobacillus_bifermentans_025Lactobacillus_bifermentans_JN175330_205

Bacteria_G2WUYFR02DS0HK_Solenopsis_5551.001.001.001.001.00

Lactobacillus_backi_DQ406862_122M58813_Lactobacillus_coryniformis_026uncultured_bacterium_GQ479965_192

1.001.001.001.001.00

Lactobacillus_rennini_LSP576007_046Lactobacillus_halophilus_AB240455_081

1.001.001.001.001.000.790.790.790.790.79

0.800.800.800.800.800.990.990.990.990.99

Paralactobacillus_selangorensis_NR_024885_282Lactobacillus_algidus_AB033209_277Lactobacillus_satsumensis_AB362683_166Lactobacillus_oeni_EU821345_180

0.930.930.930.930.93

Lactobacillus_cacaonum_AM905389_079M58824_Lactobacillus_mali_029

Lactobacillus_hordei_EU074850_147Lactobacillus_mali_FJ157230_225

0.960.960.960.960.960.640.640.640.640.640.960.960.960.960.96

Lactobacillus_capillatus_AB365978_052Lactobacillus_sucicola_AB458681_087

0.570.570.570.570.57

Lactobacillus_uvarum_EU345000_075Lactobacillus_sp._IMCC1736_DQ664203_078

0.680.680.680.680.680.880.880.880.880.88

0.630.630.630.630.63

0.260.260.260.260.26

Lactobacillus_nagelii_AB162131_073Lactobacillus_ghanensis_DQ523489_133

1.001. 001.001.001.00

Lactobacillus_mobilis_AB242320_188uncultured_Lactobacillus_sp._HM218831_198

uncultured_Lactobacillus_sp._HM218848_097uncultured_Lactobacillus_sp._HM218858_445

1.001.001.001.001.001.001.001.001.001.000.860.860.860.860.86

0.900.900.900.900.90

M58807_Lactobacillus_animalis_024Lactobacillus_apodemi_AJ871178_070uncultured_bacterium_DQ075206_041Lactobacillus_murinus_AJ621554_134

uncultured_bacterium_DQ815470_203uncultured_bacterium_DQ815437_216

0.930.930.930.930.93

uncultured_bacterium_EU791129_449uncultured_bacterium_EU790976_453

0.820.820.820.820.82

Lactobacillus_Q2_F7SSZP003G8XXC_330uncultured_bacterium_EU791098_446

0.810.810.810.810.81

Lactobacillus_Q9_F7SSZP003GEOFA_358Lactobacillus_Q1_F7SSZP003G0JMG_353Lactobacillus_Q1_F7SSZP003FIY29_362

1.001.001.001.001.000.810.810.810.810.810.310.310.310.310.31

0.470.470.470.470.47

0.800.800.800.800.80

0.950.950.950.950.95

Lactobacillus_equi_AB425924_190Bacteria_G4RPUYA02C9XKQ_Mycocepurus_476

M58803_Lactobacillus_agilis_021uncultured_bacterium_AB559729_186

0.650.650.650.650.650.810.810.810.810.811.001.001.001.001. 00

Lactobacillus_sp._C33LV5_AF197125_262uncultured_bacterium_AB506300_187M58828_Lactobacillus_ruminis_030Lactobacillus_ruminis_AB326354_112

0.590.590.590.590.591.001.001.001.001.000.950.950.950.950.95

0.360.360.360.360.36

Lactobacillus_ceti_AM292799_150Lactobacillus_saerimneri_AY255802_227Lactobacillus_sp._MbBipro17_HM534774_325Lactobacillus_sp._Tporo2_HM534775_324Lactobacillus_pobuzihii_AB326365_111Lactobacillus_sp._MbBbr1_HM534771_321

Lactobacillus_sp._121B_AF305930_261Lactobacillus_acidipiscis_AB023836_617

0.630.630.630.630.630.450.450.450.450.450.800.800.800.800.80

0.650.650.650.650.651.001.001.001.001.00

Lactobacillus_hayakitensis_AB267406_118uncultured_bacterium_AY212750_418

1.001.001.001.001.00

Bacteria_G4RPUYA02EQEGE_Mycocepurus_494Lactobacillus_salivarius_AB186340_107Lactobacillus_salivarius_EU428010_141

Bacteria_G4RPUYA02DHK61_Mycocepurus_477uncultured_Lactobacillus_sp._AY672088_235Bacteria_G4RPUYA02DJDFD_Mycocepurus_489Bacteria_G4RPUYA02EYMBR_Mycocepurus_540

Bacteria_G2WUYFR01BYHUN_Solenopsis_557Bacteria_G4RPUYA02D1FDL_Mycocepurus_483

Bacteria_G4SXT0Z01B916P_Solenopsis_5650.330.330.330.330.330.720.720.720.720.72

0.240.240.240.240.24

0.190.190.190.190.190.710.710.710.710.71

0.590.590.590.590.59

Bacteria_G4RPUYA02DQ24F_Mycocepurus_487uncultured_bacterium_GU293196_197

Lactobacillus_intermedius_AB167386_090Bacteria_G2WUYFR02DBVUH_Solenopsis_606

0.510.510.510.510.510.230.230.230.230.23

Bacteria_G2WUYFR01AL9EQ_Solenopsis_576Lactobacillus_GeEuTuBc0029_G1OJGBH03GOLAZ_376Lactobacillus_aviarius_AB001837_276Bacteria_G4RPUYA02EBAXL_Mycocepurus_538

0.630.630.630.630.63

Bacteria_G4RPUYA02EALIM_Mycocepurus_479Bacteria_G4RPUYA02EECR6_Mycocepurus_478

Bacteria_G4RPUYA02DLZY4_Mycocepurus_542Bacteria_G4RPUYA02ECJZU_Mycocepurus_504Bacteria_G4RPUYA02DSRND_Mycocepurus_481

Bacteria_G4RPUYA02EHKZP_Mycocepurus_4820.460.460.460.460.46

Bacteria_G4RPUYA02EKHNN_Mycocepurus_490Bacteria_G4RPUYA02DOSON_Mycocepurus_485

Bacteria_G4RPUYA02C1C45_Mycocepurus_5230.240.240.240.240.240.100.100.100.100.100.140.140.140.140.14

Bacteria_G4RPUYA02DCJC6_Mycocepurus_501Bacteria_G4RPUYA02EGVOD_Mycocepurus_539

0.700.700.700.700.70

Bacteria_G4RPUYA02EDTH9_Mycocepurus_493Bacteria_G4RPUYA02D8Y4Y_Mycocepurus_499

Bacteria_G4RPUYA02DJDR6_Mycocepurus_5160.500.500.500.500.500.260.260.260.260.26

0.900.900.900.900.90

0.100.100.100.100.10

0.240.240.240.240.24

0.310.310.310.310.310.310.310.310.310.310.200.200.200.200.200.500.500.500.500.50

0.290.290.290.290.290.500.500.500.500.50

0.070.070.070.070.07

0.130.130.130.130.13

0.230.230.230.230.23

0.350.350.350.350.35

0.250.250.250.250.25

0.540.540.540.540.54

0.420.420.420.420.42

0.610.610.610.610.61

0.540.540.540.540.54

Lactobacillus_concavus_AY683322_076uncultured_bacterium_AM930364_456

1.001.001.001.001.00

Lactobacillus_dextrinicus_D87679_131uncultured_bacterium_AM500777_455

1.001.001.001.0 01.001.001.001.001.001.00

Lactobacillus_composti_AB268119_058Lactobacillus_perolens_Y19167_260

Lactobacillus_harbinensis_AB368915_129Lactobacillus_brevis_AY974809_168

0.990.990.990.990.991.001.001.001.001.000.450.450.450.450.45

Lactobacillus_floricola_AB523781_173Lactobacillus_sp._MbBipro19_HM534770_312

1.001.001.001.001.00

Lactobacillus_tucceti_LSP576006_181Lactobacillus_nodensis_AB332024_415

0.890.890.890.890.89

Lactobacillus_letivazi_AJ417738_257Lactobacillus_versmoldensis_AJ496791_256

uncultured_bacterium_AF371492_223Lactobacillus_nantensis_AY690834_627Lactobacillus_crustorum_FJ645924_184Lactobacillus_farciminis_AJ417499_254Lactobacillus_mindensis_LSP313530_050

M58804_Lactobacillus_alimentarius_022Lactobacillus_bobalius_AY681134_080

Lactobacillus_kimchii_AF183558_6150.500.500.500.500.500.960.960.960.960.96

0.550.550.550.550.550.330.330.330.330.330.960.960.960.960.96

1.001.001.001.001.000.290.290.290.290.29

0.380 .380.380.380.380.260.260.260.260.26

0.740.740.740.740.74

Lactobacillus_sp._Thmro15_HM534814_319uncultured_Lactobacillus_sp._HM113222_148

uncultured_Lactobacillus_sp._HM046576_088uncultured_Firmicutes_bacterium_DQ837632_286Lactobacillus_sp._F7_EU753690_289

0.820.820.820.820.821.001.001.001.001.000.720.720.720.720.72

0.540.540.540.540.54

Lactobacillus_sp._Adhmto19_HM534810_323uncultured_Lactobacillus_sp._HM112055_149

uncultured_Lactobacillus_sp._HM113158_2260.240.240.240.240.240.640.640.640.640.64

uncultured_Firmicutes_bacterium_HM215043_121uncultured_Firmicutes_bacterium_HM215041_119uncultured_Firmicutes_bacterium_HM215042_120

0.970.970.970.970.971.001.001.001.001.00

uncultured_Bacilli_bacterium_HM113258_155uncultured_Firmicutes_bacterium_DQ837631_473uncultured_Firmicutes_bacterium_DQ837630_474

1.001.001.001.001.000.860.860.860.860 .861.001.001.001.001.00

0.240.240.240.240.24

0.450.450.450.450.45

Lactobacillus_amylotrophicus_AM236149_114M58806_Lactobacillus_amylophilus_023uncultured_bacterium_AM500848_457

0.960.960.960.960.961.001.001.001.001.00

Bacteria_G2WUYFR01ALAWT_Solenopsis_575Bacteria_G2WUYFR02DXBGU_Solenopsis_561

Lactobacillus_sp._TS3_AB284946_102Bacteria_G2WUYFR01BMLOS_Solenopsis_568

Bacteria_G2WUYFR01AWLV8_Solenopsis_567Bacteria_G2WUYFR02EUU2R_Solenopsis_592

0.650.650.650.650.65

Bacteria_G2WUYFR02D8NSR_Solenopsis_588Bacteria_G2WUYFR01AY213_Solenopsis_609

0.810.810.810.810.81

Bacteria_G2WUYFR02D6JYS_Solenopsis_586Bacteria_G2WUYFR01B9IUO_Solenopsis_602

0.380.380.380.380.38

Bacteria_G2WUYFR02DYQIU_Solenopsis_591Bacteria_G2WUYFR01CEH5G_Solenopsis_599

0.750.750.750.750.750.380.380.380.380.38

0.280.280.280.280.28

0.340.340.340.340.340.210.210.210.210.21

0.330.330.330.330.330.750.750.750.750 .75

0.050.050.050.050.05

0.040.040.040.040.04

0.000.000.000.000.00

Lactobacillus_fuchuensis_AB370875_109Lactobacillus_graminis_AM113778_045Bacteria_G28NS4E02EPXZY_Solenopsis_583Lactobacillus_curvatus_AM113777_621

0.340.340.340.340.34

Lactobacillus_sakei_EU555174_224uncultured_bacterium_DQ922980_431

0.810.810.810.810.81

Bacteria_G2WUYFR01BCWHI_Solenopsis_580Bacteria_G2WUYFR01BEKHY_Solenopsis_562Bacteria_G2WUYFR01BNE8X_Solenopsis_596

0.360.360.360.360.36

Bacteria_G2WUYFR01BQJEU_Solenopsis_569Bacteria_G2WUYFR01B93S1_Solenopsis_597

0.200.200.200.200.200.510.510.510.510.510.140.140.140.140.14

0.170.170.170.170.170.500.500.500.500.50

0.860.860.860.860.86

Lactobacillus_thailandensis_AB257863_060Lactobacillus_pantheris_AB362679_172

0.990.990.990.990.99

uncultured_compost_bacterium_FN667294_204uncultured_bacterium_AF371503_244

M58831_Lactobacillus_sharpeae_033Bacteria_G2WUYFR02D4CBL_Solenopsis_581

0 .990.990.990.990.99

Lactobacillus_guizhouensis_GU138576_113Lactobacillus_guizhouensis_EF433578_124

0.500.500.500.500.500.960.960.960.960.96

0.910.910.910.910.910.340.340.340.340.34

0.740.740.740.740.74

Lactobacillus_camelliae_AB257864_074uncultured_bacterium_GQ477902_196

uncultured_bacterium_GQ477899_2400.780.780.780.780.780.970.970.970.970.97

Bacteria_G2WUYFR02D1R7T_Solenopsis_560uncultured_compost_bacterium_FN667075_209Lactobacillus_nasuensis_AB608051_412

1.001.001.001.001.000.300.300.300.300.30

Lactobacillus_manihotivorans_AF000163_259Bacteria_G2WUYFR02D23R9_Solenopsis_570

uncultured_compost_bacterium_FN667077_210Bacteria_G2WUYFR02DXNIT_Solenopsis_604

0.780.780.780.780.780.350.350.350.350.350.600.600.600.600.60

0.720.720.720.720.72

0.380.380.380.380.38

Lactobacillus_saniviri_AB602569_307Lactobacillus_sp._Akpobro1_HM534767_314

1.001.001.001.0 01.00

Lactobacillus_sp._LM_17_AJ132757_417Lactobacillus_rhamnosus_EU184020_170

Lactobacillus_sp._N3_1_1_AB379909_2490.850.850.850.850.850.260.260.260.260.26

Lactobacillus_zeae_D86516_613X61135_Lactobacillus_casei_039M23928_Lactobacillus_casei_040Bacteria_G4RPUYA02DO5UR_Mycocepurus_498Bacteria_G4RPUYA02DGY9G_Mycocepurus_503

Bacteria_G4RPUYA02C44TI_Mycocepurus_553

0.850.850.850.850.850.800.800.800.800.80

0.460.460.460.460.46

Lactobacillus_larvae_AY667700_464Lactobacillus_GeEuF1Bc0029_G1OJGBH03GBVJ2_383

Lactobacillus_GeEuL2Bc0029_G1OJGBH03FPFCW_399Lactobacillus_paracasei_AY773954_215

Lactobacillus_sp._N1_5_2_AB379908_2510.360.360.360.360.36

Lactobacillus_sp._N4_4_AB379912_452Bacteria_G2WUYFR02D35PT_Solenopsis_566

0.390.390.390.390.39

Lactobacillus_GeEuF1Bc0029_G1OJGBH03G7UHR_377Lactobacillus_GeEuF1Bc0029_G1OJGBH03HE4SG_381Lactobacillus_GeEuF1Bc0029_G1OJGBH03GD18U_386Lactobacillus_GeEuF1Bc0029_G1OJGBH03FXRZZ_396Lactobacillus_GeEuF1Bc0029_G1OJGBH03HA4AJ_401

0.680.680.680.680.680.300.300.300.300.300.130.130.130.130.13

0.130.130.130.130.13

0.190.190.190.190.19

0.060.060.060.060.06

0 .500.500.500.500.50

0.300.300.300.300.30

0.260.260.260.260.26

Pediococcus_pentosaceus_AB362987_053Bacteria_G2WUYFR02EYU2C_Solenopsis_608

0.530.530.530.530.53

uncultured_compost_bacterium_FN667076_208uncultured_bacterium_AF371496_213

0.780.780.780.780.78

Lactobacillus_senmaizukei_AB297927_414Lactobacillus_hammesii_AJ632219_043Lactobacillus_parabrevis_AM158249_095

Lactobacillus_sp._1.1424_FN185731_099uncultured_compost_bacterium_FN667298_211

0.590.590.590.590.590.590.590.590.590.590.090.090.090.090.090.360.360.360.360.36

Lactobacillus_brevis_ATCC_367_CP000416_f_177Bacteria_G2WUYFR02C9Q6O_Solenopsis_578

M58810_Lactobacillus_brevis_014X61134_Lactobacillus_brevis_013Bacteria_G2WUYFR01BA4B4_Solenopsis_564

0.410.410.410.410.41

Lactobacillus_brevis_ATCC_367_CP000416_o_176Lactobacillus_brevis_ATCC_367_CP000416_l_179Lactobacillus_brevis_ATCC_367_CP000416_c_174Lactobacillus_brevis_ATCC_367_CP000416_175

0.240.240.240.240.240.400.400.400.400.40

Bacteria_G2WUYFR02EUR0O_Solenopsis_574Bacteria_G2WUYFR01CAH48_Solenopsis_603

0.970.970.970.970.97

Lactobacillus_spicheri_LSP534844_059Lactobacillus_namurensis_AM259118_096

Lactobacillus_acidifarinae_AJ632158_093Lactobacillus_zymae_AJ632157_094

0.990.990.990.990.990.910.910.910.910.910.700.700.700.700.70

0.470.470.470.470.47

0.280.280.280.280.28

0.470.470.470.470.47

0.420.420.420.420.42

0.340.340.340.340.34

Lactobacillus_senioris_AB602570_298Lactobacillus_sp._Akporo7_HM534765_311

1.001.001.001.001.00

Lactobacillus_sp._JKD6_AF264701_614Lactobacillus_parafarraginis_AB262734_622

Lactobacillus_sp._r2_GQ247886_123M58821_Lactobacillus_hilgardii_017M59295_Lactobacillus_sp._034

0.440.440.440.440.440.950.950.950.950.95

Lactobacillus_farraginis_HM534766_139Lactobacillus_farraginis_AB262732_183Lactobacillus_faeni_AB362687_428

0.600.600.600.600.601.001.001.001.001.000.780.780.780.780.78

0.600.600.600.600.600.250.250 .250.250.25

Lactobacillus_sp._NGRI_0130_AB362984_250Lactobacillus_rapi_AB366389_624

0.950.950.950.950.95

Lactobacillus_kisonensis_AB366388_628Lactobacillus_sp._rennanqilfy19_AY363377_237Lactobacillus_parabuchneri_AB205056_626

0.570.570.570.570.57

Lactobacillus_fermentum_FJ844993_130Lactobacillus_kefiri_AJ621553_135

1.001.001.001.001.00

Lactobacillus_otakiensis_AB366386_620Lactobacillus_sunkii_AB366385_625M58811_Lactobacillus_buchneri_015Lactobacillus_parakefiri_AY026750_612

0.860.860.860.860.860.400.400.400.400.400.380.380.380.380.380.640.640.640.640.640.840.840.840.840.840.510.510.510.510.510.510.510.510.510.51

0.820.820.820.820.82

0.890.890.890.890.89

Lactobacillus_ozensis_AB572588_051Lactobacillus_sp._MbBipro7_HM534743_313

0.960.960.960.960.96

uncultured_Bacilli_bacterium_HM112474_145uncultured_Lactobacillus_sp._HM008721_068

Lactobacillus_sp._Am_09_AJ971903_295Lactobacillus_kunkeei_AB559820_185Lactobacillus_kunkeei_EU753691_291

0.990.990.990.990.990.550.550.550.550.550.960 .960.960.960.960.550.550.550.550.55

uncultured_Bacilli_bacterium_HM109480_143uncultured_Bacilli_bacterium_HM109610_144uncultured_Bacilli_bacterium_HM112778_146

0.990.990.990.990.99

uncultured_Bacilli_bacterium_HM112623_467Lactobacillus_Q7A_F348WMR04JBQ2M_333Lactobacillus_Q7A_F348WMR04JGOIJ_334

Lactobacillus_Q7A_F348WMR04IFQ7D_360Lactobacillus_Q7A_F348WMR04JDJG4_363

Lactobacillus_Q7A_F348WMR04JKTXT_340Lactobacillus_Q7A_F348WMR04JKJ8J_611

1.001.001.001.001.000.230.230.230.230.230.610.610.610.610.610.230.230.230.230.23

0.240.240.240.240.240.410.410.410.410.41

0.490.490.490.490.49

Lactobacillus_GeEuF1Bc0029_G1OJGBH03GX6IB_397Lactobacillus_GeEuF1Bc0029_G1OJGBH03G5C2A_398Lactobacillus_GeEuF1Bc0029_G1OJGBH03HAYWD_403

0.400.400.400.400.400.970.970.970.970.97

Lactobacillus_GeSoB2Bc0019_G1OJGBH03FWMY4_392Lactobacillus_GeSoB2Bc0019_G1OJGBH03GHBHU_382

Lactobacillus_GeSoB2Bc0019_G1OJGBH03FQASF_390Lactobacillus_GeEuB2Bc0029_G1OJGBH03G4ZG5_389Lactobacillus_GeEuA1Bc0029_G1OJGBH03GHVOY_407Lactobacillus_GeEuPeBc0029_G1OJGBH03FN2ZU_366Lactobacillus_GeEuF1Bc0029_G1OJGBH03GZEIB_379Lactobacillus_GeEuL2Bc0029_G1OJGBH03G5A0S_404Lactobacillus_GeEuB2Bc0029_G1OJGBH03F1OGP_372Lactobacillus_GeEuPeBc0029_G1OJGBH03G6R03_373Lactobacillus_GeEuL2Bc0029_G1OJGBH03F6ICY_393

0.260.260.260.260.26

Lactobacillus_GeSoL1Bc0019_G1OJGBH03GQQ4M_370Lactobacillus_GeEuPeBc0029_G1OJGBH03F3HKE_395

Lactobacillus_GeSoB2Bc0019_G1OJGBH03HCW2S_384Lactobacillus_GeEuB2Bc0029_G1OJGBH03FPP40_408

0.330.330.330.330.33

Lactobacillus_GeEuF1Bc0029_G1OJGBH03FKN70_385Lactobacillus_GeEuF1Bc0029_G1OJGBH03F5LSE_409

Lactobacillus_GeEuF1Bc0029_G1OJGBH03G4BBA_394Lactobacillus_GeEuF1Bc0029_G1OJGBH03GL6DL_400

0.400.400.400.400.400.550.550.550.550.550.310.310.310.310.31

0.070.070.070.070.07

0.010.010.010.010.010.040.040.040.040.040.030.030.030.030.03

0.100.100.100.100.10

0.390.390.390.390.39

0.130.130.130.130.130.160.160.160.160.16

0.330.330.330.330.33

0.360.360.360.360.36

0.360.360.360.360 .36

Lactobacillus_sp._MbBipto3_HM534760_308Lactobacillus_sp._Mbhoto3_HM534763_310

1.001.001.001.001.00

X76330|g535112_Lactobacillus_fructivorans_028Lactobacillus_homohiochii_AJ621552_128

0.960.960.960.960.96

Lactobacillus_sp._Akhmbto4_HM534764_306Lactobacillus_florum_AB498047_048Lactobacillus_florum_AB498046_103

1.001.001.001.001.00

Lactobacillus_lindneri_X95421_252X61132_Lactobacillus_sanfrancisco_031X76327|g535106_Lactobacillus_sanfrancisco_032

1.001.001.001.001.000.860.860.860.860.860.820.820.820.820.82

1.001.001.001.001.000.930.930.930.930.93

Lactobacillus_Q13_F7SSZP003FI5FN_326Lactobacillus_Q13_F7SSZP003HFPEY_331Lactobacillus_Q13_F7SSZP003G5ZTS_349

Lactobacillus_Q1_F7SSZP003G3NEK_3520.790.790.790.790.790.190.190.190.190.19

0.230.230.230.230.23

Lactobacillus_Q1_F7SSZP003GUV9L_378Lactobacillus_Q11_F7SSZP003GTXXJ_354Lactobacillus_Q1_F7SSZP003GSQA4_329

Lactobacillus_Q1_F7SSZP003GRNEB_339Lactobacillus_Q1_F7SSZP003F337Q_327Lactobacillus_Q1_F7SSZP003HB7B3_332

0.560.560.560.560.560.360.360.360.360.36

Lactobacillus_Q11_F7SSZP003HHA6K_338Lactobacillus_Q1_F7SSZP003HBKSR_328

Lactobacillus_Q1_F7SSZP003HHGTB_3350.400.400.400.400.400.130.130.130.1 30.13

0.400.400.400.400.400.820.820.820.820.82

0.900.900.900.900.90

Lactobacillus_Q13_F7SSZP003FP9MZ_359Lactobacillus_Q1_F7SSZP003GZRYO_348

Lactobacillus_Q13_F7SSZP003GTPZN_375Lactobacillus_Q13_F7SSZP003FK90P_365Lactobacillus_Q1_F7SSZP003GVG3B_367

0.280.280.280.280.28

Lactobacillus_Q13_F7SSZP003FNTFE_361Lactobacillus_Q1_F7SSZP003G9G18_364

Lactobacillus_Q1_F7SSZP003FO813_3740.530.530.530.530.530.050.050.050.050.050.070.070.070.070.07

Lactobacillus_Q1_F7SSZP003F6H96_369Lactobacillus_Q13_F7SSZP003GLX8O_347

Lactobacillus_Q1_F7SSZP003HB207_344Lactobacillus_Q13_F7SSZP003GSJYU_350Lactobacillus_Q1_F7SSZP003G83HT_355Lactobacillus_Q1_F7SSZP003FQFVI_368

0.930.930.930.930.930.820.820.820.820.82

Lactobacillus_Q1_F7SSZP003FVDOE_343Lactobacillus_Q1_F7SSZP003GB27S_351

Lactobacillus_Q1_F7SSZP003FZBLV_345Lactobacillus_Q13_F7SSZP003HAPYQ_346

Lactobacillus_Q1_F7SSZP003FZDPQ_356Lactobacillus_Q1_F7SSZP003FJ41T_341

Lactobacillus_Q1_F7SSZP003FKU5E_3570.460.460.460.460.46

Lactobacillus_Q1_F7SSZP003FV2DK_342Lactobacillus_Q13_F7SSZP003GM303_371

0.130.130.130.130.130.030.030.030.030.03

0.010.010.010.010.010.090.090.090.090.09

0.030.030.030.030.030.000.0 00.000.000.000.050.050.050.050.05

0.060.060.060.060.060.070.070.070.070.07

0.070.070.070.070.070.050.050.050.050.05

0.040.040.040.040.04

0.030.030.030.030.03

0.060.060.060.060.06

0.070.070.070.070.07

0.200.200.200.200.20

0.630.630.630.630.63

0.300.300.300.300.30

0.260.260.260.260.26

0.390.390.390.390.39

0.310.310.310.310.31

0.070.070.070.070.07

0.060.060.060.060.06

Lactobacillus_malefermentans_AM113783_182Bacteria_G2WUYFR02DUYD5_Solenopsis_559

0.990.990.990.990.99

Lactobacillus_sp._DCY51_EU678893_106Bacteria_G2WUYFR02DN04P_Solenopsis_556

Lactobacillus_collinoides_AB005893_044Lactobacillus_paracollinoides_AB159218_167

1.001.001.001 .001.00

Lactobacillus_odoratitofui_AB365975_108Lactobacillus_similis_AB282889_077Bacteria_G2WUYFR02ERHIP_Solenopsis_600

0.640.640.640.640.640.460.460.460.460.460.540.540.540.540.54

0.510.510.510.510.510.740.740.740.740.74

0.800.800.800.800.80

uncultured_bacterium_AF371494_220Lactobacillus_GeEuF1Bc0029_G1OJGBH03F8WFB_405

Bacteria_G2WUYFR02DVW1P_Solenopsis_598Bacteria_G28NS4E02DMQ1E_Solenopsis_594

Bacteria_G2WUYFR02D1WHH_Solenopsis_572Bacteria_G2WUYFR02D5DLK_Solenopsis_607

0.880.880.880.880.880.200.200.200.200.20

Lactobacillus_fabifermentans_AM905388_072Lactobacillus_plantarum_FJ915797_245

Bacteria_G28NS4E02EJUZ3_Solenopsis_601Lactobacillus_plantarum_JN126052_160

Lactobacillus_japonicus_AB681817_411Bacteria_G28NS4E02C3G8Q_Solenopsis_577

Bacteria_G28NS4E02DIEI6_Solenopsis_5930.510.510.510.510.51

0.030.030.030.030.03

Lactobacillus_plantarum_AJ965482_127D79211_Lactobacillus_pentosus_018

Lactobacillus_plantarum_AM279758_2020.100.100.100.100.10

M58827_Lactobacillus_plantarum_019Lactobacillus_plantarum_FJ386491_169

0.240.240.240.240.24

Lactobacillus_plantarum_FN252881_447Lactobacillus_plantarum_AB371712_238

Bacteria_G2WUYFR02DYMES_Solenopsis_6100.760.760.760.760.760.300.300.300.300.30

Lactobacillus_plantarum_AB371714_248Bacteria_G4RPUYA02D9F7Z_Mycocepurus_531

Bacteria_G28NS4E02DQD3U_Solenopsis_5580.600.600.600.600.600.130.130.130.130.13

0.060.060.060.060.06

0.030.030.030.030.03

0.010.010.010.010.01

0.140.140.140.140.14

0.340.340.340.340.34

0.090.090.090.090.09

0.500.500.500.500.50

0.760.760.760.760.76

0.140.140.140.140.14

Lactobacillus_siliginis_AB370882_413Lactobacillus_rossiae_LSP564009_156Lactobacillus_rossiae_AM920328_061Bacteria_G4RPUYA02DO47R_Mycocepurus_541

0.590.590.590.590.59

Lactobacillus_GeEuF1Bc0029_G1OJGBH03GO5Q0_380Lactobacillus_GeEuF1Bc0029_G1OJGBH03HCYM0_388Lactobacillus_GeEuF1Bc0029_G1OJGBH03FYH6Y_406

Lactobacillus_GeEuF1Bc0029_G1OJGBH03G2VUK_391Lactobacillus_GeEuF1Bc0029_G1OJGBH03G2OEC_402

0.850.850.850.850.850.590.590.590.590.590.590.590.590.590.59

0.690.690.690.690.691.001.001.001.001.00

Lactobacillus_suebicus_LSU575744_162Lactobacillus_vaccinostercus_AB362691_419Bacteria_G2WUYFR02DYIH7_Solenopsis_573

1.001.001.001.001.000.970.970.970.970.97

Lactobacillus_oligofermentans_AY733084_110uncultured_bacterium_HQ716645_236

0.530.530.530.530.53

Bacteria_G2WUYFR02EJBF3_Solenopsis_595Bacteria_G4RPUYA02EP6UO_Mycocepurus_488

Bacteria_G4RPUYA02D4F5G_Mycocepurus_5140.910.910.910.910.910.610.610.610.610.61

0.990.990.990.990.99

0.840.840.840.840.84

Lactobacillus_equigenerosi_AB288050_091Lactobacillus_antri_AY253658_157

0.850.850.850.850.85

Lactobacillus_fermentum_AF522394_253Lactobacillus_fermentum_EF535257_234

Bacteria_G2WUYFR01A00YD_Solenopsis_585M58819_Lactobacillus_fermentum_027Lactobacillus_fermentum_GQ131191_132

0.460.460.460.460.460.190.190.190.190.19

1.001.001.001.001.000.750.750.750.750.75

Lactobacillus_sp._G24_AF197126_258Lactobacillus_mucosae_AF126738_616

1.001.001.001.001.00

Lactobacillus_alvi_HQ718585_410Lactobacillus_ingluviei_AF308147_255

Bacteria_G4RPUYA02D2F2O_Mycocepurus_4961. 001.001.001.001.000.760.760.760.760.76

Lactobacillus_sp._TMW_1.1309_AM279150_189uncultured_bacterium_AB559717_435Lactobacillus_coleohominis_AM113776_623

1.001.001.001.001.00

Lactobacillus_sp._oral_taxon_052_GQ422710_042X94230|g1313964_Lactobacillus_panis_038

uncultured_bacterium_GQ505032_4540.780.780.780.780.78

uncultured_bacterium_HM218875_432Lactobacillus_kalixensis_AY253659_158X94229|g1313963_Lactobacillus_oris_035uncultured_bacterium_AB559668_434

0.970.970.970.970.970.990.990.990.990.990.530.530.530.530.531.001.001.001.001.00

uncultured_bacterium_AY958911_433X61136_Lactobacillus_vaginalis_036

Lactobacillus_vaginalis_HM534769_138Lactobacillus_vaginalis_AF243177_264Bacteria_G4RPUYA02ENLBJ_Mycocepurus_529

0.240.240.240.240.240.230.230.230.230.230.570.570.570.570.57

Lactobacillus_frumenti_LSP250074_629X76329|g534948_Lactobacillus_pontis_037Bacteria_G4RPUYA02C1IZC_Mycocepurus_534

0.930.930.930.930.93

Lactobacillus_sp._Akhmro1_HM534768_309Lactobacillus_reuteri_F275_AP007281_062Lactobacillus_reuteri_F275_AP007281_c_063Lactobacillus_reuteri_F275_AP007281_n_064Lactobacillus_reuteri_F275_AP007281_f_065Lactobacillus_reuteri_F275_AP007281_q_066Lactobacillus_reuteri_F275_AP007281_i_067

0.880.880.880.880.88

uncultured_bacterium_EU791265_443uncultured_bacterium_EU791072_430Bacteria_G4RPUYA02EQ6U1_Mycocepurus_546

Bacteria_G4RPUYA02DJ8IV_Mycocepurus_533Bacteria_G4RPUYA02D2IM2_Mycocepurus_549

0.590.590.590.590.59

uncultured_bacterium_EU791134_438Bacteria_G4RPUYA02C82F5_Mycocepurus_513

Bacteria_G4RPUYA02C82QY_Mycocepurus_5450.690.690.690.690.690.510.510.510.510.51

0.050.050.050.050.050.410.410.410.410.41

0.930.930.930.930.93

Bacteria_G4RPUYA02C02W1_Mycocepurus_517Bacteria_G4RPUYA02C8GJU_Mycocepurus_520

Bacteria_G4RPUYA02DBPUF_Mycocepurus_522uncultured_bacterium_GQ175588_243

uncultured_bacterium_EU791181_247uncultured_bacterium_EU791159_440uncultured_bacterium_EU791116_439Bacteria_G4RPUYA02D4ZHO_Mycocepurus_550

0.440.440.440.440.44

AY239419_uncultured_bacterium_012Bacteria_G4RPUYA02DD4H3_Mycocepurus_544Bacteria_G4RPUYA02ECX6B_Mycocepurus_551

uncultured_bacterium_EU622700_459Bacteria_G4RPUYA02DAS3I_Mycocepurus_547

0.420.420.420.420.420.140.140.140.140.140.040.040.040.040.04

0.030.030.030.030.03

Bacteria_G2WUYFR01CFJ17_Solenopsis_579AE017198_Lactobacillus_johnsonii_NCC_533_006AE017198_Lactobacillus_johnsonii_NCC_533_007AE017198_Lactobacillus_johnsonii_NCC_533_008AE017198_Lactobacillus_johnsonii_NCC_533_009AE017198_Lactobacillus_johnsonii_NCC_533_010AE017198_Lactobacillus_johnsonii_NCC_533_011Lactobacillus_johnsonii_EU780913_140Bacteria_G4RPUYA02D066W_Mycocepurus_506Bacteria_G4RPUYA02DN9RG_Mycocepurus_515Bacteria_G4SXT0Z01BWJ7N_Solenopsis_582uncultured_bacterium_EU791127_442

Bacteria_G4RPUYA02DLV9U_Mycocepurus_521Bacteria_G4RPUYA02DCLGW_Mycocepurus_500

Bacteria_G4RPUYA02EL5KB_Mycocepurus_495Bacteria_G4RPUYA02EE9DE_Mycocepurus_527

0.780.780.780.780.780.280.280.280.280.280.110.110.110.110.11

0.060.060.060.060.06

Bacteria_G4RPUYA02DANKJ_Mycocepurus_519Bacteria_G4RPUYA02D9HKG_Mycocepurus_528Bacteria_G4RPUYA02C93MK_Mycocepurus_554Bacteria_G4RPUYA02C8Q5C_Mycocepurus_525Bacteria_G4RPUYA02DPY4I_Mycocepurus_532

0.540.540.540.540.540.210.210.210.210.210.170.170.170.170.17

Lactobacillus_taiwanensis_EU487512_084Lactobacillus_iatae_EF187258_137

0.410.410.410.410.41

Lactobacillus_gasseri_ATCC_33323_AF519171_618Lactobacillus_sp._61D_FR681902_426AY959035_uncultured_bacterium_004AY958891_uncultured_bacterium_005

uncultured_bacterium_EF653412_219uncultured_bacterium_AY959115_463

uncultured_bacterium_AY959095_241uncultured_bacterium_AY959163_436

uncultured_Firmicutes_bacterium_EF682866_049Lactobacillus_iners_Y16329_057uncultured_bacterium_AY959039_239

Bacteria_G4RPUYA02DE844_Mycocepurus_530Bacteria_G4RPUYA02EQ2ZF_Mycocepurus_537

0.160.160.160.160.160.650.650.650.650.65

0.200.200.200.200.200.360.360.360.360.36

0.400.400.400.400.40

Bacteria_G4RPUYA02D30I7_Mycocepurus_543Lactobacillus_crispatus_AJ242969_265

Bacteria_G4RPUYA02EGYQJ_Mycocepurus_492Bacteria_G4RPUYA02D6ETP_Mycocepurus_491

Bacteria_G4RPUYA02C254J_Mycocepurus_4970.740.740.740.740.74

Lactobacillus_GeEuPeBc0029_G1OJGBH03GSTGE_387Bacteria_G4RPUYA02C1VXY_Mycocepurus_510

Bacteria_G4RPUYA02C8GY8_Mycocepurus_507Bacteria_G4RPUYA02C8R7C_Mycocepurus_536

0.710.710.710.710.71

Bacteria_G4RPUYA02DNU3H_Mycocepurus_512Bacteria_G4RPUYA02D69JH_Mycocepurus_552

0.470.470.470.470.470.170.170.170.170.170.140.140.140.140.140.050.050.050.050.05

Bacteria_G4RPUYA02D481Y_Mycocepurus_524Lactobacillus_crispatus_EU559595_178Bacteria_G4RPUYA02C45QD_Mycocepurus_486Bacteria_G4RPUYA02D8UIL_Mycocepurus_548

0.940.940.940.940.940.130.130.130.130.13

Lactobacillus_crispatus_DQ317604_098Bacteria_G4RPUYA02C41OQ_Mycocepurus_502Bacteria_G4SXT0Z01B38UP_Solenopsis_584

0.960.960.960.960.960.460.460.460.460.46

uncultured_bacterium_AY958844_441Bacteria_G4RPUYA02DQ2EG_Mycocepurus_508

uncultured_bacterium_AY958858_054uncultured_bacterium_AY958900_201

0.880.880.880.880.880.640.640.640.640.64

uncultured_bacterium_DQ057433_465Lactobacillus_gallinarum_LGA417737_047

uncultured_bacterium_GQ267932_217Lactobacillus_acidophilus_EU878007_125Lactobacillus_helveticus_EU419585_221

0.840.840.840.840.840.340.340.340.340.340.090.090.090.090.090.150.150.150.150.15

M58802_Lactobacillus_acidophilus_003uncultured_bacterium_FJ880117_199

0.860.860.860.860.86

Lactobacillus_kitasatonis_AB186339_115Lactobacillus_acidophilus_AY773947_126

Bacteria_G4RPUYA02D8O9Y_Mycocepurus_5090.130.130.130.130.130.230.230.230.230.230.560.560.560.560.56

uncultured_bacterium_GQ267930_218uncultured_bacterium_GQ267866_229

Bacteria_G4RPUYA02DHIVZ_Mycocepurus_505Bacteria_G4RPUYA02DBPK8_Mycocepurus_511

0.510.510.510.510.510.090.090.090.090.09

uncultured_bacterium_DQ318873_421Bacteria_G4RPUYA02D2L56_Mycocepurus_480

0.550.550.550.550.55

Lactobacillaceae_bacterium_DJF_003_EU728746_101uncultured_bacterium_DQ318874_191

0.960.960.960.960.96

Lactobacillus_equicursoris_AB290830_116Lactobacillus_sp._66c_FR681900_427

1.001.001.001.001.00

M58823_Lactobacillus_delbrueckii_016Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_X_301Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_CV_302Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_CY_304Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_B_297Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_CC_299Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_S_305

0.050.050.050.050. 05

uncultured_bacterium_GQ267952_214Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_DJ_296Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_CK_300Lactobacillus_delbrueckii_subsp._bulgaricus_2038_CP000156_BA_303

0.210.210.210.210.21

0.140.140.140.140.14

0.410.410.410.410.410.780.780.780.780.78

0.720.720.720.720.72

0.910.910.910.910.91

0.420.420.420.420.42

0.070.070.070.070.07

0.110.110.110.110.11

0.030.030.030.030.03

0.030.030.030.030.03

Lactobacillus_ultunensis_AY253660_159Lactobacillus_kefiranofaciens_subsp._kefiranofaciens_AM113781_630

0.360.360.360.360.36

uncultured_compost_bacterium_FN667084_212uncultured_Lactobacillus_sp._HM218856_458

Bacteria_G4RPUYA02DQODF_Mycocepurus_526Bacteria_G4RPUYA02C1VT3_Mycocepurus_535

0.690.690.690.690.690.350.350.350.350. 35

uncultured_Lactobacillus_sp._HM218874_085Bacteria_G4RPUYA02D1G4P_Mycocepurus_518

uncultured_Lactobacillus_sp._HM218864_193uncultured_Lactobacillus_sp._HM218878_451

1.001.001.001.001.000.280.280.280.280.280.230.230.230.230.23

0.070.070.070.070.070.060.060.060.060.06

uncultured_bacterium_FJ682870_232Bacteria_G2WUYFR01AP069_Solenopsis_571

0.570.570.570.570.57

uncultured_Lactobacillus_sp._HM218839_462Bacteria_G4SXT0Z01B6HAY_Solenopsis_563

0.070.070.070.070.07

Lactobacillus_amylovorus_GRL_1112_CP002338_A_161Lactobacillus_amylovorus_GRL_1112_CP002338_K_163Lactobacillus_amylovorus_GRL_1112_CP002338_AQ_164Lactobacillus_amylovorus_GRL_1112_CP002338_BQ_165Bacteria_G4RPUYA02ED17E_Mycocepurus_484uncultured_Lactobacillus_sp._HM218861_246

uncultured_Lactobacillus_sp._HM218863_4200.230.230.230.230.23

uncultured_Lactobacillus_sp._HM218833_460uncultured_Lactobacillus_sp._HM218869_461

0.880.880.880.880.88

uncultured_Lactobacillus_sp._HM218868_448uncultured_Lactobacillus_sp._HM218862_444uncultured_Lactobacillus_sp._HM218873_450

0.410.410.410.410.410.630.630.630.630.63

0.030.030.030.030.03

0.050.050.050.050.05

0.070.070.070.070.07

0.000.000.000.000.00

uncultured_Lactobacillus_sp._HM218837_086uncultured_bacterium_HM218871_194uncultured_bacterium_HM218855_195

0.610.610.610.610.610.570. 570.570.570.57

uncultured_bacterium_AY958851_055uncultured_bacterium_AY958918_422

Lactobacillus_psittaci_LPS272391_142Lactobacillus_jensenii_EU559601_171Lactobacillus_fornicalis_Y18654_619

0.960.960.960.960.960.650.650.650.650.650.410.410.410.410.41

0.660.660.660.660.660.050.050.050.050.05

Lactobacillus_hamsteri_LHA306298_104Lactobacillus_amylolyticus_DSM_11664_Y17361_263

0.660.660.660.660.66

uncultured_bacterium_HM218836_437Lactobacillus_gastricus_AY253657_230

Lactobacillus_intestinalis_LIN306299_100Lactobacillus_sp._ASF360_AF157050_273

uncultured_bacterium_AY239415_206uncultured_bacterium_AY239416_207

0.990.990.990.990.99

Lactobacillus_Q1_F7SSZP003GT0PR_336Lactobacillus_Q13_F7SSZP003GZ6SM_337

0.930.930.930.930.930.760.760.760.760.760.930.930.930.930.93

uncultured_Lactobacillus_sp._HM218872_429uncultured_Lactobacillus_sp._FJ192637_089

uncultured_bacterium_GU808381_200M58801_Lactobacillus_acetotolerans_020Lactobacillus_acetotolerans_FR683099_105

0.990.990.990.990.99

Bacteria_G2WUYFR01BBUKF_Solenopsis_605Lactobacillus_sp._Mbhsr5_HM534808_318Lactobacillus_sp._MbHmro1_HM534806_320

uncultured_Firmicutes_bacterium_HM215048_466Lactobacillus_sp._Adhmro12_HM534786_315Lactobacillus_sp._Afpor8_HM534796_322

0.350.350.350.350.350.050.050.050.050.05

Lactobacillus_sp._Afpoto13_HM534795_316Lactobacillus_sp._Aahonto7_HM534805_317

Firmicutes_bacterium_Bt_aa_02_AJ971929_293Lactobacillus_sp._Mardanium_GU233458_288

Lactobacillus_sp._Taj_KS164_GU233457_2900.990.990.990.990.99

uncultured_Lactobacillus_sp._HM113326_468uncultured_Lactobacillus_sp._HM046568_082uncultured_Lactobacillus_sp._HM046579_083

0.790.790.790.790.79

uncultured_Firmicutes_bacterium_DQ837634_469uncultured_Firmicutes_bacterium_DQ837635_471Bacteria_G2WUYFR01A2OJ0_Solenopsis_589

0.260.260.260.260.260.390.390.390.390.39

0.310.310.310.310.31

uncultured_Lactobacillus_sp._HM113281_154uncultured_Bacilli_bacterium_HM113257_425

0.540.540.540.540.54

uncultured_Lactobacillus_sp._AY370183_071uncultured_Firmicutes_bacterium_DQ837637_472

0.530.530.530.530.53

uncultured_Lactobacillus_sp._HM113333_151uncultured_Lactobacillus_sp._HM112866_153

0.290.290.290.290.29

uncultured_Lactobacillus_sp._HM112010_424Lactobacillus_alvei_AY667698_136Lactobacillus_sp._3b_EU753698_294

0.310.310.310.310.310.440.440.440.440.440.380.380.380.380.38

Lactobacillus_apis_AY667701_222Bacteria_G4SXT0Z01AYJLY_Solenopsis_587

0.890.890.890.890.89

uncultured_Lactobacillus_sp._HM113203_152Lactobacillus_insectis_AY667699_283

Lactobacillus_sp._B3_EU753697_292uncultured_Firmicutes_bacterium_DQ837636_470

0.540.540.540.540.540.470.470.470.470.47

0.190.190.190.190.19

0.260.260.260.260.26

0.450.450.450.450.45

0.300.300.300.300.30

0.040.040.040.040.04

0.000.000.000.000.000.030.030.030.030.03

0.390.390.390.390.39

0.330.330.330.330.330.360.360.360.360.36

0. 380.380.380.380.380.350.350.350.350.35

0.210.210.210.210.210.040.040.040.040.04

0.040.040.040.040.04

0.000.000.000.000.00

0.000.000.000.000.00

0.000.000.000.000.00

0.040.040.040.040.04

0.000.000.000.000.00

0.000.000.000.000.00

0.000.000.000.000.00

0.010.010.010.010.01

0.010.010.010.010.01

0.000.000.000.000.00

0.000.000.000.000.00

0.010.010.010.010.01

0.070.070.070.070.07

0.010.010.010.010.01

0.190.190.190.190.19

0. 050.050.050.050.05

0.060.060.060.060.06

0.070.070.070.070.070.050.050.050.050.050.070.070.070.070.070.030.030.030.030.03

0.000.000.000.000.00

0.000.000.000.000.00

0.000.000.000.000.00

0.010.010.010.010.01

0.070.070.070.070.07

0.110.110.110.110.110.070.070.070.070.07

0.380.380.380.380.38

0.070.070.070.070.07

0.040.040.040.040.04

0.030.030.030.030.03

0.040.040.040.040.04

0.040.040.040.040.04

0.060.060.060.060.06

0. 000.000.000.000.00

0.050.050.050.050.05

0.050.050.050.050.05

0.030.030.030.030.03

0.090.090.090.090.09

0.060.060.060.060.06

0.050.050.050.050.05

0.000.000.000.000.00

0.010.010.010.010.01

0.010.010.010.010.01

0.010.010.010.010.01

0.040.040.040.040.04

0.010.010.010.010.01

0.040.040.040.040.04

0.050.050.050.050.05

0.030.030.030.030.03

0.060.060.060.060.06

0.350.350.350.350.35

0.750.750.750.750.75

Firm5

Fig. S2 E.

Table S1. Simple sequence statistics of three 16S rDNA sequence alignments. Alignment All characters Constant Variable Autapomorphic

Full-length 2206 852 853 501 Partial 783 221 411 151

Combined 2273 834 929 510

!Table S2. Mycocepurus smithii-associated OTUs broken down into number of reads associated with workers versus number of reads associated with the fungus-garden.!Mycocepurus-associated OTU

# reads from fungus garden

# reads from workers

Top BLAST hit

Percent sequence identity

OTU 1 Garden=6203 Worker=7943 L. johnsonii 99% sequence identity OTU 2 Garden=1879 Worker=1869 L. crispatus 99% sequence identity OTU 3 Garden=1493 Worker=1301 L. salivarius 97% sequence identity OTU 4 Garden=660 Worker=399 L. aviarius 99% sequence identity OTU 5 Garden=628 Worker=178 L. crispatus 98% sequence identity OTU 6 Garden=143 Worker=455 L. salivarius 99% sequence identity OTU 7 Garden=479 Worker=107 L. reuteri 99% sequence identity OTU 8 Garden=23 Worker=408 L. salivarius 98% sequence identity OTU 9 Garden=307 Worker=113 L. aviarius 90% sequence identity OTU 10 Garden=408 Worker=1 L. johnsonii 95% sequence identity

!