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GulfWarIllnessResearchProgram(DoD/CDMRP):Newly-fundedProjectsin2015(FY14Funds)

PREPAREDBY:VETERANSFORCOMMONSENSE.LastUpdatedFebruary16,2016Thetreatment-focusedGulfWarIllnessResearchProgram(GWIRP)isoneofseveralmedicalresearchprogramsintheCongressionallyDirectedMedicalResearchProgram(CDMRP)portfoliowithintheU.S.DepartmentofDefense(DoD).TheGWIRPcompetitivelyfundsinnovativeGulfWarIllnessresearchtoidentifyeffectivetreatments,improvedefinitionanddiagnosis,andbetterunderstandpathobiologyandsymptoms.ItsvisionistoimprovethehealthandlivesofveteranswhohaveGulfWarIllness.i

ItwasinitiatedbyCongressinfederalfiscalyear2006(FY06)toprovidesupportformedicalresearchofexceptionalscientificmeritrelatedtothehealtheffectsofdeploymentonU.S.Warfightersduringthe1991PersianGulfWar.iThispaperlistseachofthestudiesfundedbytheGWIRPin2015(FY14funds),withhyperlinkstoeachproject’slayandscientificabstracts.

PILOTSTUDIESOFTREATMENTSFUNDEDIN2015

1. D-Cycloserine:ANovelTreatmentforGulfWarIllness,R.Toomey,BostonUniv.MedicalCampus,MA(GW140069)

2. EffectofDietonGulfWarIllness:APilotStudy,A.Tuteja,WesternInstituteforBiomedicalResearch,UT(GW140074)

3. VagusNerveStimulationasaTreatmentStrategyforGulfWarIllness,L.Shapiro,TexasA&MUniv.SystemHealthScienceCenter,TX(GW140097)

4. DesigningaSuccessfulAcupunctureTreatmentProgramforGulfWarIllness,L.Conboy,NewEnglandSchoolofAcupuncture,Boston,MA(GW140138)

5. ExtendingBenefitsofQ10:MitochondrialCocktailforGulfWarIllness,B.Golomb,Univ.ofCalif.-SanDiego,CA(GW140146)

6. TestingtheModel:APhaseI/IIRandomizedDoubleBlindPlaceboControlTrialofTargetedTherapeutics:LiposomalGlutathioneandCurcumin,N.Klimas,SouthFloridaVeteransAffairsFoundationforResearchandEducation,Inc.,FL&R.Deth,NovaSoutheasternUniv.,FL(GW140153,GW140153P1)

7. Double-Blind,Placebo-ControlledCrossoverStudyoftheAnti-InflammatoryCompoundAnatabinetoTreatPaininGWIPatients,F.Crawford,RoskampInstitute,FL(GW140159)

8. VagusNerveStimulation:ANoninvasiveTreatmenttoImprovetheHealthofGulfVeteranswithGulfWarIllness,B.Natelson,BethIsraelMedicalCenter,NY(GW140157)

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STUDIESOFUNDERLYINGMECHANISMSANDBIOMARKERSFUNDEDIN2015

9. VascularandSkeletalMuscleFunctioninGulfWarVeteransIllness,S.Kinlay,BostonVA

ResearchInstitute,MA(GW140035)

10. MuscleMitochondrialAssessmentsinGulfWarIllness,B.Golomb,Univ.ofCalif.-SanDiego,CA(GW140045)

11. GulfWarIllnessasaBrainAutoimmuneDisorder,A.Georgopolous,Univ.ofMinn.-TwinCities,MN(GW140053)

12. STARTandSTOPPinGWI,J.Baraniuk,GeorgetownUniv.,DC(GW140064)

13. NeurovascularandAutonomicDysfunctionAssociatedwithGulfWarIllnessPain,B.Cooper,Univ.ofFla.,FL(GW140066)

14. AnIntegratedGenomicsandCellBiologyApproachtoCorrelateNovelGWIIndicatorsofInfectionsandNeuroinflammatoryMechanismswithTargetedDrugTherapy,P.Waziry,NovaSoutheasternUniv.,FL(GW140077)

15. PreclinicalTreatmentofanOrganophosphateModelofGulfWarIllness,H.Speed,Univ.ofTexasSouthwesternMedicalCenteratDallas,TX(GW140091)

16. MicrotubuleAbnormalitiesUnderlyingGulfWarIllnessinNeuronsfromHuman-InducedPluripotentCells,P.Baas,DrexelUniv.,PA(GW140086)

17. StudiesofBiomarkersandBrainMechanismsofGulfWarIllness,D.C.Shungu,WeillCornellSchoolofMedicine,CornellUniv.,NY(GW140114)

18. NovelAutoantibodySerumandCerebrospinalFluidBiomarkersinVeteranswithGulfWarIllness,K.Sullivan,BostonUniv.MedicalCampus,MA&M.Abou-Donia,DukeUniv.,NC(GW140140,GW140140P2)

19. High-FidelityDesignofMultimodalRestorativeInterventionsinGulfWarIllness,G.Broderick,NovaSoutheasternUniv.,FL&D.Whitley,Colo.StateUniv.,CO(GW140142)

20. AnObjectiveBloodTestfromStimulatedGeneExpressionforClassificationandOutcomeAssessmentinClinicalTrialsofGulfWarIllness,Dr.’sR.Haley&E.Wakeland,Univ.ofTexasSouthwesternMedicalCenteratDallas,TX(GW140158,GW140158P1)

21. DiagnosisofLate-Stage,Early-Onset,Small-FiberPolyneuropathy,A.L.Oaklander,MassachusettsGeneralHospital,MA&J.Serrador,VeteransBiomedicalResearchInstitute,NJ(GW140169,GW140169P1)

iGulfWarIllnessResearchProgram(GWIRP),CongressionallyDirectedMedicalResearchProgram,U.SDepartmentofDefense,ProgramWebsite.RetrievedJan.24,2016,http://cdmrp.army.mil/gwirp.