h v mendenhall cv, 4 6-15

H. V. Mendenhall DVM, PhD Curriculum Vitae

As of April 6, 2015

H. VINCE MENDENHALL Consultant, Preclinical Surgery

EDUCATION:

1981 Ph.D., (Experimental Surgery) Colorado State University

1968 DVM, Colorado State University

PROFESSIONAL EXPERIENCE:

2015-Present Consultant, Preclinical Surgery

Consults with sponsors on preclinical study designs for necessary

animal studies on newly developed medical devices in all specialties, performing extensive discovery and developmental work along with pilot studies to establish a definitive GLP protocol.

Emphasizes the importance of selection of the correct animal model and other techniques in order to gain definitive results that are translatable to the human condition.

Will accompany the sponsor for necessary FDA panel meetings if so desired.

Writes definitive protocols, acts as "on-site Study Director" for the sponsor, and will actually perform the necessary surgical procedures and follow up examinations and necropsies and help direct histopathological and other endpoints, including MRI, CT and microCT examinations. Writes the final report for the study, suitable for submission to the FDA.

Involved in specialized toxicology studies from the standpoint of targeted drug delivery and specialized pharmacokinetics, i.e., CSF, bile duct implants for first pass pharmacokinetics, and lymphatic PK.


As of April 6, 2015

2008-2015 Director, Preclinical Translational Services, Wake Forest Innovation

Quarter, Winston-Salem, NC.

Responsible for offering Industry partners a central contact point for

contract, “fee-for-service”, non-clinical surgical research.

Responsible to the Wake Forest Innovation Quarter tenants with a

local resource for non-clinical surgical research.

Responsible for providing Wake Forest University faculty with a

training and internal resource to further their skills in non-clinical

surgical research.

2012-2014 Affiliate Faculty Member of the Center for Biomolecular Imaging, Wake

Forest University, Winston-Salem, NC.

1993-2008 Principal Scientist, Preclinical Surgery, Charles River Laboratories,

Preclinical Services, Shrewsbury, MA.

Responsible for the overall operation of the Surgical Facility,

including the operating rooms, anesthesia management, analgesia,

fluid therapy, perioperative care and monitoring, radiological

support, and all associated equipment.

Responsible for the conduct of the surgical portion of any study.

Responsible for the actual performance of any surgical procedure

that other members of the Department have not been adequately

trained to perform.

Responsible for training and professional development of

veterinarians and Research Assistants in the performance of routine

surgical procedures, anesthesia and aseptic technique.

May serve as Study Director on any study in which the surgical

component is a primary part of the Study Design.

Serve as consultant to all Departments and Laboratories of Charles

River Laboratories, Preclinical Services, for studies that have a

surgical component.

1992-1993 Consultant, Biomedical Surgical Research, Stillwater, MN

Provided independent contract surgical support for Contract

Laboratories in the performance of their studies that had a surgical

component.


As of April 6, 2015

1982-1991 Senior Surgical Research Specialist, 3M Center, St. Paul, MN

Was responsible for the overall operation of the Surgical Facility,

including the operating rooms, anesthesia, radiological support, and

all associated equipment.

Was responsible for the research phases involved in the

development of new surgical devices in the areas of neurology,

orthopedics, cardiovascular, ophthalmic and general abdominal

surgery, as well as in wound healing research.

Was responsible for the actual performance of any surgical

procedure that other members of the Department have not been

adequately trained to perform.

Was responsible for training of Surgical Technicians in the

performance of routine surgical procedures, anesthesia and aseptic

technique.

Served as Study Director on any study that involved the

implantation of a new surgical device.

Served as a keynote speaker and trainer in the use of marketed

surgical devices to international physicians in 28 countries.

1977-1993 Owner/Operator of Veterinary Surgical Specialists, (Referral Surgery)

Was responsible for the performance of clinical veterinary cases

requiring complicated and difficult surgery. These procedures were

primarily of an orthopedic nature, although many cases involved

thoracic, abdominal and ophthalmic procedures.

1975-1982 Surgical Research Specialist, 3M Center, St. Paul, MN

Developed and designed the Surgical Research Facility within 3M

to serve as an internal contract laboratory to all Medical Device

Divisions, including Orthopedics, Dental, Wound Care,

Ophthalmic and Cardiovascular (Sarns), including the operating

rooms, anesthesia, radiological support, and all associated

equipment.

Was responsible for the research phases involved in the

development of new surgical devices in these Divisions.

Was responsible for the actual performance of any surgical

procedure that other members of the Department have not been

adequately trained to perform.

Was responsible for training of Surgical Technicians in the

performance of routine surgical procedures, anesthesia and aseptic

technique.


As of April 6, 2015

Served as Study Director on any study which involved the

implantation of a new surgical device.

1975-1977 Emergency and Relief General Practitioner, and Referral Surgeon, St.

Paul, MN

Responsible for the Emergency Care of animals for several private

veterinary clinics in Minneapolis and St. Paul, MN.

Responsible for the conduct of difficult clinical surgical procedures

on a referral basis from over 100 private veterinary clinics in

Minneapolis and St. Paul, MN.

1974-1975 Staff Vascular Surgeon, Surgical Laboratory, Colorado State University

Responsible for the actual surgical procedures involved in funded

NIH grants for which there was a vascular surgical component.

1973 Lecturer in Surgical Anatomy, Colorado State University

Responsible for the preparation and delivery of lectures in the basics

of anatomy as it related to surgical procedures of all types to third

year veterinary students.

1972-1975 Staff Neurosurgeon, Veterinary Teaching Hospital, Colorado State

University

Responsible for the actual surgical procedures involved in approved

NIH grants for which there was a neurosurgical surgical component.

This work was primarily related to spinal cord injury research.

Responsible for the surgical correction of any traumatic injury to the

spinal cord of dogs and cats.

1972-1974 Second Assistant in human General, Neuro and Cardiovascular Surgery,

Poudre Valley Memorial Hospital, Fort Collins, Colorado

Had the OR responsibilities of a second year physician resident in

general, neuro- and cardiovascular surgery.

1971-1975 Graduate Student in Experimental Surgery, Surgical Laboratory,

Colorado State University

Completed the course work necessary for a PhD in Experimental

Surgery.


As of April 6, 2015

1968-1971 General Veterinary Practice, Assistant Senior Veterinarian and Staff

Surgeon, Rangitaiki Plains Dairy Company, Edgecumbe, New Zealand

Responsible for the veterinary care of all types of animals, primarily

dairy cows, horses and small animals (dogs and cats).

PROFESSIONAL AFFILIATIONS:

Society for Biomaterials

Delta Chapter, Phi Zeta

Academy of Surgical Research

Elected member: European Society for Knee Surgery and Arthroscopy

Who's Who in Frontiers of Science & Technology - 1985

Who's Who in Veterinary Science & Medicine - 1991-1992

Who’s Who in Science and Engineering - 1998-1999

Who’s Who in America – 1999-2003

Strathmore’s Who’s Who – 1999-2002

The Lexington Who’s Who Registry – 2000-2002

Who’s Who in the World – 2001-2003

AWARDS:

1982 – Outstanding PhD Dissertation - Society of Biomaterials

2002 Von Recum Award for outstanding contributions to the field of investigative surgical

research and the Academy of Surgical Research.

President, Academy of Surgical Research, 2004-2005

BOOK CHAPTERS AND MONOGRAPHS:

1. Mendenhall, HV. Evaluation of polypropylene as an artificial anterior cruciate ligament in

dogs, Ph.D. Thesis, Ft. Collins, Colorado, (c) 1981.

2. Mendenhall, HV. Principal considerations for experimental surgical procedures, The

Handbook of Biomaterials Evaluation, MacMillan Publishing Company, 265-275, 1986.

3. Mendenhall, HV. General Surgical Considerations, Handbook of Biomaterials Evaluation,

MacMillan Publishing Company, 251-289, 1986.


As of April 6, 2015

4. Van Kampen, CL, Mendenhall, HV, McPherson, GK. “Synthetic augmentation of

biological anterior cruciate ligament substitutions" in The Anterior, Cruciate Deficient

Knee: New Concepts in Ligament Repair, The C.V. Mosby Co., 1987.

5. Mishra, N, Mendenhall, HV, Willson, J. Guidance Document for the Preparation of

Investigational Device Exemptions and Premarket Approval Applications for Intra-

articular Prosthetic Knee Ligament Devices. U.S. Department of Health and Human

Services, Food and Drug Administration, Center for Devices and Radiological Health,

Rockville, MD 20850, September 1, 1987

6. Mendenhall, HV. Surgical principles of biomaterial implantation, Encyclopedic

Handbook of Biomaterials and Bioengineering, Marcel Dekker, Inc. 1-26, 1995.

7. Mendenhall, HV, Horvath, C, Piechowiak, M, Johnson, L, Bayer, K. An External Thoracic

Duct Venous Shunt to Allow for Long Term Collection of Lymph and Blood in the

Conscious Pig. Advances in Swine in Biomedical Research, vol.2. 621-627, 1996.

8. Mendenhall, HV. Animal Models for Preclinical Testing of Medical Devices.

Biomaterials and Bioengineering Handbook. Ed. Wise DL. Marcel Dekker, Inc. 199-204,

2000.

9. Mendenhall, HV. Animal Selection, Handbook of Biomaterials Evaluation, 2nd Ed. Taylor

& Francis, 475-480, 1999.

10. Mendenhall, HV. Surgical Procedures, Handbook of Biomaterials Evaluation, 2nd Ed.

Taylor & Francis, 481-492, 1999

11. Mendenhall, HV, Cornell, S, Scalaro, M. Surgical Preparation and Infusion of the Large

Primate. In: Handbook of Pre-clinical Continuous Intravenous Infusion, Ed. Healing G.,

Smith D., p161-180. Taylor and Francis, 2000.

REFEREED PUBLICATIONS:

1. Mendenhall, HV, Litwak, P, Yturraspe, DJ, Ingram, JT, Lumb, WV. Aggressive

pharmacologic and surgical treatment of spinal cord injuries in dogs and cats, J Am Vet

Med Assoc, (1976) 168(11), 1026-1031.

2. Kennedy, JC, Roth, JH, Mendenhall, HV, Sanford, JB. Intraarticular replacement in the

anterior cruciate ligament-deficient knee, Am J Sports Med, (1980) 8(1), 1-8.

3. Siegel, LG, Mendenhall, HV, Liston, SL. Christmas bow pins: a potential inhaled foreign

body made safer by industrial modifications, So Med J, (1981) 74(1), 17-20.


As of April 6, 2015

4. Ibid. Today's OR Nurse, (1981) 3(3), 24.

5. Ibid. 1982 Yr Bk of Pediatrics, (1982) Yr Bk Med Pub, Chicago.

6. Mendenhall, HV, McPherson, GK, Gibbons, DF, Plenk, H. Jr., Rottmann, W, Sanford, JB,

Kennedy, JC. Histological and Mechanical Evaluation of the Ligament Augmentation

Device. Trans Am Soc Artif Intern Organs (1983) 29:314-7.

7. McPherson, GK, Mendenhall, HV, Gibbons, DF, Plenk, H, Rottman, W, Sanford, JB,

Kennedy, JC, Roth, JH. Experimental mechanical and histologic evaluation of Kennedy

ligament augmentation device, Clin Ortho Rel Res, (1985) 196, 186-195.

8. Fredell, PA, Solem, LD, Ahrenholz, DH, Bahmet, W, Grussing, DM, Mendenhall, HV,

Erickson, EH, Trancik, RJ. Determination of silver penetration into burn eschar by atomic

absorption, J Burn Care Rehab, (1985) 6(1), 55-57.

9. Mendenhall, HV, Roth, JH, Kennedy, JC, Winter, GD, Lumb, WV. Evaluation of the

polypropylene braid as a prosthetic anterior cruciate ligament replacement in the dog, Am

J Sports Med, (1987) 15(6), 543-546.

10. Jackson, D.W., Grood, E.S., Arnoczky, S.P., Butler, D. L., Simon, T.M., Mendenhall, H.V.

Cruciate reconstruction using freeze dried anterior cruciate ligament allograft and a

ligament augmentation device (LAD): an experimental study in a goat model, Am J of

Sports Med (1987) 15(6), 528-538.

11. Holden, J.P., Grood, E.S., Butler, D.L., Noyes, F.R., Mendenhall, H.V., Van Kampen,

C.L., Neidich, R.L. Biomechanics of fascia lata ligament replacements: early post-

operative changes in the goat, J of Orthopaedic Res 6, 639-647, 1988.

12. Roth, J.H., Mendenhall, H.V., McPherson, G.K. The effect of immobilization on goat

knees following reconstruction of the anterior cruciate ligament, Clinical Orthopaedics

229, 278-282, 1988.

13. Falconer, D.P., Lewis, T.W., Lamprecht, E.G., Mendenhall, H.V. Evaluation of the Unilink

Microvascular Anastomotic Device in the dog, J Reconstructive Microsurgery 6(3), 215-

222, 1990.

14. Tountas, C.P., Bergman, R.A., Lewis, T.W., Stone, H.E., Pyrek, J.D., Mendenhall, H.V. A

comparison of peripheral nerve repair using an absorbable tubulization device and

conventional suture in primates, J of Applied Biomaterials 4, 261-268, 1993.

15. Gibbons, D.F., Mendenhall, H.V., Van Kampen, C.L., Lamprecht, E.G. The effect of

motion on the tissue response to polymeric fiber implants, Clin Mat 15, 37-41, 1994.


As of April 6, 2015

16. Atkinson, TS, Atkinson, PJ, Mendenhall, HV, Haut, RC. Patellar Tendon and Infrapatellar

Fat Pad Healing after harvest of an ACL Graft. J Surg Res, 79(1): 25-30, 1998.

17. Badylak, S., Arnoczky, S., Plouhar, P. Haut, R., Mendenhall, V., Clarke, R., Horvath, C.

Naturally Occurring Extracellular Matrix as a Scaffold for Musculoskeletal Repair.

Clinical Orthopedics and Related Research, 367S, S333-S343, 1999.

18. Chen, SA, Sawchuk, RJ, Brundage, RC, Horvath, C, Mendenhall, HV, Gunther, RA,

Braeckman, RA. Plasma and Lymph Pharmacokinetics of Recombinant Human

Interleukin-2 and Polyethylene Glycol-Modified Interleukin-2 in Pigs. Journal of

Pharmacology and Experimental Therapeutics, 293:248-259, 2000.

19. Qing-Qing Q, Mendenhall, H.V., Garlick, D.S., Connor, J. Evaluation of Bone

Regeneration at Critical-Sized Calvarial Defect by DBM/AM Composite. J Bio Mat Res

Part B: Applied Biomaterials. 81B, Issue 2 (2006), 516-523.

20. Cornacoff JB, Howk K, Pikounis B, Mendenhall V, Martin P. Development of a method

for the evaluation of wound tensile strength in cynomolgus macaques. J Pharm Tox

Methods, 57 (2008), 74-79.

21. Mendenhall HV: Book Review: BSAVA Manual of Canine and Feline Anaesthesia and

Analgesia. Journal of Investigative Surgery, 21:47-48, 2008.

22. Mendenhall V, Baran SW, Johnson EJ, Perret-Gentil MI. Aseptic Technique in rodent

surgery: why should I pay attention? Animal Laboratory News. April 2010.

23. Hutchinson RW, Mendenhall V, Abutin RM, Muench T, Hart J. Evaluation of fibrin

sealants for central nervous system sealing in the mongrel dog durotomy model.

Neurosurgery. 2011 October; 69(4): 921-8.

24. Mendenhall V, Baran S, Johnson E, Perret-Gentil M. Aseptic Technique in Rodent

Surgery: Why Should I Pay Attention? ALN World Issue, September/October 2011.

25. Michael A, Buffen E, Rauck R, Anderson W, McGirt M, Mendenhall HV. An in vivo

Canine Study to Assess Granulomatous Responses in the MedStream Programmable

Infusion SystemTM and the SynchroMed II Infusion System®. Pain Medicine, 13(2): 175-

84, 2012.

26. Buttermann GR, Mendenhall HV. Feasibility of the Runt Cow for in vivo Testing of a

Spinal Interbody Prosthesis with Preliminary Results. J Invest Surg, 25,112-122, 2012.

http://www.ncbi.nlm.nih.gov/pubmed/21552173


As of April 6, 2015

27. Schroedter WB, Burke SK, Blair A, Mendenhall HV. Comparison of In Vivo

Arteriovenous Fistula Volume Flow Measurements Using a Transonic Transit-Time

Ultrasound Flow Device and Doppler Ultrasound. J Vasc Ultrasound 38(4) 187-197, 2014.

28. Ding H, Hayashida K, Suto T, Sukhtankar DD, Kimura M, Mendenhall V, Ko MC.

Supraspinal actions of N/OFQ, morphine and substance P in regulating pain and itch in

nonhuman primates. Br J Pharmacol. 2015 Mar 5. doi: 10.1111/bph.13124.

CONFERENCE PROCEEDINGS:

1. Mendenhall HV, Grussing DM, Henderson JD Jr, McPherson GK, Sanford JB, Kennedy

JC, Roth JH. Prosthetic augmentation of autogenous tissue for repair of anterior cruciate

ligament disability, 26th Ann Mtg of the Orthopaedic Res Soc, Atlanta, Georgia, February

5-7, 1980.

2. Mendenhall HV, Grussing DM, Fredell PA, Henderson JD Jr, Case MT, Galbraith W,

Klein GV. A fractionated composite bromelin preparation (R-382) for removal of full

thickness burn eschar in swine, 13th Ann Mtg of the Amer Burn Assoc, Washington, D.C.,

April 2-4, 1981.

3. Mendenhall HV, Grussing DM, Henderson JD Jr, McPherson GK, Sanford JB, Kennedy

JC, Roth JH. 7th Ann Mtg of the Soc for Biomaterials, Troy, New York, May 27-31, 1981.

4. Mendenhall HV. Cruciate ligament surgery, 7th Ann Mtg of the Minn Assoc of Vet Tech,

Minneapolis, Minnesota, January 30-31, 1982.

5. Mendenhall HV. Engineering principles behind polypropylene as a ligament augmentation

device and animal experimentation, Kennedy Lig Augmentation Device Symp, Univ of

Western Ontario, London, Ontario, April 24, 1982.

6. Mendenhall HV. Evaluation of polypropylene as an artificial anterior cruciate ligament in

the dog, Student's Award Papers, 8th Ann Mtg of the Soc for Biomaterials, Orlando,

Florida, April 24-27, 1982.

7. Mendenhall HV, McPherson GK, Plenk HR, Rottmann W, Sanford JB, Grussing DM,

Kennedy JC, Galpin R. Evaluation of the ligament augmentation device after long term

implantation in goats, 8th Ann Mtg of Soc for Biomaterials, Orlando, Florida, April 24-27,

1982.

8. Mendenhall HV, Winter GD, Henderson JD Jr, Fredell PA, Grussing DM, Erickson EH.

Skin grafting in swine following burn eschar debridement with R-832, Int Soc for Burn

Injuries, San Francisco, California, August 29-September 4, 1982.


As of April 6, 2015

9. Fredell P, Solem LD, Ahrenholz DH, Bahmet W, Grussing DM, Mendenhall HV, Erickson

EH, Trancik R. Determination of silver penetration into burn eschar by atomic absorption,

15th Ann Mtg of the Amer Burn Assoc, New Orleans, Louisiana, March 16-19, 1983.

10. Mendenhall HV, McPherson GK, Gibbons DF, Plenk H Jr, Rottmann NW, Sanford JB,

Kennedy JC. Histologic and mechanical evaluation of the ligament augmentation device,

29th Ann Mtg Amer Soc for Artificial Internal Organs, Toronto, Canada, April 28-30, 1983.

11. Mendenhall HV, McPherson GK, Gibbons DF, Plenk H Jr, Rottmann W, Sanford JB,

Grussing DM, Kennedy JC. Evaluation of the ligament augmentation device after two year

implantation in goats, 9th Ann Mtg of Soc for Biomaterials, Birmingham, Alabama, April

27-May 1, 1983.

12. McPherson GK, Mendenhall HV, Sanford JB, Gibbons DF, Kennedy JC. The use of

polypropylene braid as a perioperative facilitator in the repair of chronic anterior cruciate

ligament injuries: the Kennedy LAD, Symp on Artificial Ligaments, New York, New York,

November 30-December 1, 1983.

13. Shapiro JS, Peltier L, Volz R, Mendenhall HV. Power stapling fixation: comparison with

pins, wires and screws, 51st Ann Mtg of the Amer Acad of Orthopaedic Surgeons, Atlanta,

Georgia, February 9-14, 1984.

14. Roth JH, Kennedy JC, McPherson GK, Mendenhall HV, Sanford JB, Gibbons DF. Long

term evaluation of the 'ligament augmentation device' in the reconstruction of the anterior

cruciate ligament in goats, Canadian Orthopaedic Res Soc, Winnipeg, Saskatchewan,

Canada, June 9-11, 1984.

15. Mendenhall HV. Animal studies, Symp on Prosthetic Augmentation of Autogenous Grafts,

St. Paul, Minnesota, November 10, 1984.

16. Mendenhall HV. Development of an animal research protocol, Ann Res Conf, St. Paul-

Ramsey Med Educ and Res Fndtn, St. Paul, Minnesota, November 10, 1984.

17. Mendenhall HV, McPherson GK, Grussing DM, Roth JH. The effect of full thickness

sectioning of the central one third of the patellar tendon and joint immobilization on the

knee joint of goats following reconstruction of the anterior cruciate ligament, 31st Ann Mtg,

Orthopaedic Res Soc, Las Vegas, Nevada, January 20-25, 1985.

18. Roth JH, McPherson GK, Mendenhall H.V. Polypropylene braid augmentation of anterior

cruciate ligament reconstruction - an in-vivo goat study, 52nd Ann Mtg of Amer Acad

Orthopaedic Surgeons, Las Vegas, Nevada, January 25-30, 1985.


As of April 6, 2015

19. Mendenhall HV, McPherson GK, Winter GD, Sanford JB, Kennedy JC, Roth JH.

Evaluation of polypropylene as an artificial anterior cruciate ligament in the dog, Interm

Mtg, Amer Orthopaedic Soc for Sports Med, Las Vegas, Nevada, January 23-24, 1985.

20. Mendenhall HV, Grussing DM, McPherson GK, Lumb WV. A surgical model to study in-

vivo biodegradation of filamentous polymeric biomaterials, 11th Ann Mtg of the Soc for

Biomaterials, San Diego, California, April 25-28, 1985.

21. Mendenhall HV. The domestic white goose as an animal model for intraocular surgery,

2nd Ann Scientific Session, Academy of Surgical Research, Clemson, South Carolina,

October 31-November 1, 1986.

22. Mendenhall HV. The goat as an animal model for anterior cruciate ligament reconstruction,

2nd Ann Scientific Session, Academy of Surgical Research, Clemson, South Carolina,

October 31-November 1, 1986.

23. Holden JP, Grood ES, Butler DL, Noyes FR, Mendenhall HV, VanKampen CL. Fascia lata

autograft reconstruction of the anterior cruciate ligament: Early changes in joint laxity and

graft strength, 33rd Ann Mtg, Orthopaedic Res Soc, San Francisco, California, January 19-

22, 1987.

24. Tountas CP, Bergman RA, Barrows TH, Mendenhall HV, Gibbons DF, Lewis TW, Pyrek

JD, Stone H. Peripheral nerve repair: tubulization vs. suture (a twelve-month primate

study), 42nd Ann Mtg of the Amer Soc for Surg of the Hand, San Antonio, Texas,

September 9-12, 1987.

25. Mendenhall HV. Synthetic augmentation: concept and controversies, 1st European LAD

Study Club, Cannes, France, September 11-12, 1987.

26. Mendenhall HV, Knoll RL, Cameron JD. A histological evaluation of hydrogel intraocular

lens implants in rabbits, 5th Cong of the European Intraocular Implantlens Counc,

Jerusalem, Israel, September 13-18, 1987.

27. Mendenhall HV. Long term evaluation of the ligament augmentation device: wear

characteristics, Int Sports Med Conf, Edmonton, Alberta, September 25-27, 1987.

28. Mendenhall HV. Development of LAD and animal studies, Knee Ligament Reconstruction

with Augmentation, St. Charles Medical Center and Oregon Health Sciences Univ, Sun

River, Oregon, February 20, 1988.

29. Mendenhall HV. Biomechanical and histological review of LAD, Knee Ligament

Reconstruction with Augmentation, St. Charles Med Ctr and Oregon Health Sciences Univ,

Sun River, Oregon, February 20, 1988.


As of April 6, 2015

30. Oestern HJ, Kasperczyk W, Bosch U, Sturm J, Mendenhall HV. Experimental mechanical,

histological and radiographic evaluation of use of the 'Kennedy ligament augmentation

device' (LAD) in posterior cruciate ligament reconstruction in sheep. 3rd Cong of the

European Soc of Knee Surgery and Arthroscopy, Amsterdam, the Netherlands, May 16-

20, 1988.

31. Mendenhall HV, Knoll RL, Cameron JD. A histological evaluation of hydrogel (poly-n-

vinyl-2-pyrrolidone copolymer) intraocular lens implants in rabbits, The 3rd World

Biomaterial Congress, Kyoto, Japan, April 21-25, 1988.

32. Knoll RL, Gibbons DF, Mendenhall HV. Investigation of cell attraction and adherence to

hydrogel (poly-n-vinyl-2-pyrrolidone copolymer) intraocular lens implants, The 3rd World

Biomaterial Cong, Kyoto, Japan, April 21-25, 1988.

33. Mendenhall HV. Investigation of poly-n-vinyl-2-pyrrolidone copolymer IOL explants for

attraction and/or penetration of cells and debris into the hydrogel optic, Biomaterials in

Ophthalmology: Present and Future, Kobe Univ, Kobe, Japan, April 26, 1988.

34. Mendenhall H.V. The concepts of augmentation compared to scaffolding, stents and true

prostheses in ACL reconstruction, Symp: ACL Reconstruction using the Kennedy LAD as

an Augmentation Device, Ortopedkirurgiska klinikens, Danderyd, Sweden, May 9, 1988.

35. Mendenhall HV, Knoll RL, Frederick D.M. Clinical evaluation of intraocular tissue

reactions induced by extracapsular lens extraction and implantation of dehydrated poly-n-

vinyl-2-pyrrolidone posterior chamber intraocular lenses in cynomolgus monkeys, 6th

Cong of the European Intraocular Implantlens Counc, Copenhagen, August 14-18, 1988.

36. Knoll RL, Gibbons DF, Mendenhall HV. Cell attraction and adherence to hydrogel (poly-

n-vinyl-2-pyrrolidone copolymer) intraocular lenses: an experimental study in rabbits, 6th

Cong of the European Intraocular Implantlens Council, Copenhagen, August 18-21, 1988.

37. Mendenhall HV, Knoll RL, Gibbons DF, Snowden FW, Lindstrom RL. Development of

poly-n-vinyl-2-pyrrolidone copolymer hydrogel (P-NVP) as an intraocular lens, Film

Festival, 6th Cong of the European Intraocular Implantlens Council, Copenhagen, August

18-21, 1988.

38. Mendenhall HV. Viscoelastic materials in intraocular surgery, 1st Int Symp on Quality of

Cataract Surgery, Stockholm, Sweden, August 19-20, 1988.

39. Mendenhall HV. Bone-patellar tendon-bone anterior cruciate ligament substitution in

goats, 4th Ann Scientific Session of the Academy of Surgical Research, Boston,

Massachusetts, September 15-17, 1988.


As of April 6, 2015

40. Mendenhall HV, Frederick DM, Knoll RL. Extra-capsular lens extraction and implantation

of posterior chamber intraocular lenses in cynomolgus monkeys: Preoperative preparation,

operative technique and postoperative care, 4th Ann Scientific Session of the Academy of

Surgical Research, Boston, Massachusetts, September 15-17, 1988.

41. Knoll RL, Mendenhall HV, Gibbons DF, Cameron JD. A histological evaluation of

hydrogel (poly-n-vinyl-2-pyrrolidone copolymer) intraocular lens implants in cynomolgus

monkeys, The 15th Ann Mtg of the Soc for Biomaterials, Lake Buena Vista, Florida, April

28-May 2, 1989.

42. Mendenhall HV. Biology of ligament augmentation - a 10 year overview, A Day in Sports

Med, Toronto, Canada, April 29, 1989.

43. Knoll RL, Mendenhall HV, Gibbons DF, Cameron JD. Evaluation of hydrogel (poly-n-

vinyl-2-pyrrolidone (P-NVP)) as an IOL in cynomolgus monkeys, Biomaterials in

Ophthalmology, 1st Interdisciplinary Symp, Bologna, Italy, September 1-4, 1989.

44. Mendenhall H.V. Development of poly-n-vinyl pyrrolidone (P-NVP)) as a small incision

IOL, 1st World Cong on Phacoemulsification and Small Incision IOL, Monte Carlo,


45. Mendenhall HV. The concept of synthetic augmentation of biologic tissue: 15 years of

basic research, PWV Arthroscopy Soc Mtg, Johannesburg, South Africa, October 12, 1989.

46. Mendenhall HV. Evaluation of a microvascular anastomotic device in the dog, British

Microsurgical Soc Mtg, Glasgow, January 25-26, 1990.

47. Mendenhall HV. Biology of ligament augmentation, 10th Ann Whistler Sports Med Conf,

Whistler, British Columbia, Canada, February 2-4, 1990.

48. Goertzen MJ, Mendenhall HV, Schultz KPL, Arnoczky, S.P. ACL reconstruction using

anterior cruciate ligament allografts in dogs. Results with and without ligament

augmentation device (LAD), 38th Ann Mtg of the Orthopaedic Res Soc, New Orleans,

Louisiana, February 5-8, 1990.

49. Mendenhall HV. The biology of synthetic augmentation of anterior cruciate ligament

(ACL) substitutions, 1st Workshop of the European Orthopaedic Res Soc, Aarhus,

Denmark, July 7, 1990.

50. Mendenhall HV. Animal studies with the ligament augmentation device, 4th LAD Study

Club, Edinburgh, October, 1991.


As of April 6, 2015


substitutions, Invited Lecture: 2nd Cong of Knee and Orthopaedic Sports Med Sect of the

West Pac Orthopaedic Assoc, Seoul, Korea, July 3-6, 1991.

52. Mendenhall HV. Animal studies related to surgical technique and rehabilitation in

synthetic augmentation of autogenous tissue for anterior cruciate ligament substitution,

Invited Lecture: 2nd Cong of Knee and Orthopaedic Sports Med Sect of the West Pac

Orthopaedic Assoc, Seoul, Korea, July 3-6, 1991.

53. Mendenhall HV. La biomecanique pour une augmentation synthetique reussie du croise

anterieur, Assoc D-Orthopedie du Quebec. Reunion Scientifique, Beaupre, Mont Sainte-

Anne, Quebec, Canada, February 22-23, 1992.


substitutes - animal studies and clinical considerations, Invited Lecture: Symp:

Bandchirurgie des Kniegelenkes und Bandaugmentation. Eine aktuelle

Standortbestimmung, Marburg, Germany, March 20, 1992.

55. Mendenhall HV. Biomechanics of knee ligament reconstruction, A Day in Sports Med,

Toronto, Canada, April 11, 1992.

56. Mendenhall HV. Basic research on the biology of synthetic augmentation, Symp on the

Cruciate Deficient Knee-Knee Ligament Reconstruction, Winnipeg, Canada, May 1, 1992.

57. Mendenhall HV. Biomechanics of knee ligament reconstruction, Update on Knee Ligament

Reconstruction, London, Ontario, Canada, June 13, 1992.

58. Mendenhall HV. Biomechanics of knee ligament reconstruction, A Day In Sports Medicine

- Toward Year 2000, Ottawa, Ontario, Canada, October 3, 1992.

59. Mendenhall HV. Biomechanics of knee ligament reconstruction, Current Concepts in Knee

Ligament Surgery, Vancouver, Canada, October 17, 1992.

60. Mendenhall HV. An External Thoracic Duct-Venous Shunt to Allow for Long Term

Collection of Lymph and Blood in the Conscious Pig, Society of Toxicology, Baltimore,

Maryland, March 8, 1995.

61. Cornell S, Mendenhall HV. 44 Days of Continuous Infusion into the Intrathecal Space of

Beagle Dogs using an Indwelling Catheter, Society of Toxicology, Baltimore, Maryland,

March 8, 1995.

62. Mendenhall HV. Surgical Techniques in Device Testing, 1995 Technical Workshop,

Society for Biomaterials, San Francisco, California, March 18, 1995.


As of April 6, 2015

63. Horvath CJ, Garlick D, Darrigrand A, Mendenhall HV, An Improved Anesthesia

Technique in Rabbits, Laboratory Animal Medicine Section of the American Veterinary

Medical Association, Pittsburgh, Pennsylvania, July 12, 1995.

64. Kobayashi H, Kawamoto Y, Hara S, Tomizawa N, Gibbons DF, VanKampen CL,

Mendenhall HV. Study on Bioresorbable Poly-L-Lactide (PLLA) Ligament Augmentation

Device (LAD). Proc. 4th Japan International Society for the Advancement of Material and

Process Engineering Symposium, Tokyo, Japan, September 25-28, 1995

65. Mendenhall HV, Cornell S. 44 Days of Continuous Infusion into the Intrathecal Space of

Beagle Dogs Using an Indwelling Catheter, 11th Annual Scientific Session of the Academy

of Surgical Research, Albuquerque, New Mexico, October 5-7, 1995. Published in the

Journal of Investigative Surgery, 1995, 8(4): p 317.

66. Mendenhall HV, Piechowiak M, Bayer KB. An External Thoracic Duct-Venous Shunt to

allow for Long Term Collection of Lymph and Blood in the Conscious Pig, 11th Annual

Scientific Session of the Academy of Surgical Research, Albuquerque, New Mexico,

October 5-7, 1995.

67. Mendenhall HV. A Clinically Applicable Animal model for Evaluation of Bone Graft

Substitutes and Implantable Delivery Systems for Bone Repair, 11th Annual Scientific

Session of the Academy of Surgical Research, Albuquerque, New Mexico, October 5-7,

1995. Published in the Journal of Investigative Surgery, 1995, 8(4): p 318.

68. Mendenhall HV, Horvath C, Piechowiak M, Johnson L, Bayer K. An External Thoracic

Duct-Venous Shunt to allow for long term collection of lymph and blood in the

conscious pig, Swine in Biomedical Research, International Symposium, College Park,

Maryland, October 22-25, 1995.

69. Mendenhall HV, Chronic Catheterization of the Lateral Ventricle in Cynomolgus

Monkeys, 3rd US-Japan Symposium on Drug Delivery Systems, Maui, Hawaii, December

17-22, 1995

70. Piechowiak M, Mendenhall HV, Chronic Percutaneous Catheterization of the Jugular Vein

in Mice, 3rd US-Japan Symposium on Drug Delivery Systems, Maui, Hawaii, December

17-22, 1995.

71. Piechowiak M, Mendenhall HV, Chronic Percutaneous Catheterization of the Jugular Vein

in Mice, 35th Annual Meeting of the Society of Toxicology, Anaheim, California, March

10-14, 1996.

72. Mendenhall HV, Chronic Catheterization of the Lateral Ventricle in Cynomolgus

Monkeys, 35th Annual Meeting of the Society of Toxicology, Anaheim, California, March

10-14, 1996.


As of April 6, 2015

73. Mendenhall HV, Surgical Technique to allow for Chronic Catheterization of the Lateral

Ventricle in Cynomolgus Monkeys, Exhibit Hall Demonstration, 35th Annual Meeting of

the Society of Toxicology, Anaheim, California, March 10-14, 1996.

74. Mendenhall HV, Moderator: Laboratory Animal Long-Term Access Roundtable,

Philadelphia, Pennsylvania, May 10, 1996.

75. Mendenhall HV, Piechowiak M. Chronic Catheterization of the Lateral Ventricle in

Cynomolgus Monkeys, 12th Annual and 1st International Scientific Session of the

Academy of Surgical Research, Muenster, Germany, October 3-5, 1996. Published in the

Journal of Investigative Surgery, 1996, 9(3): p 260.

76. Piechowiak M, Wadanoli M, Mendenhall HV. Technique for Implantation of a Catheter

to Allow for Infusion of Test Articles into the Intrathecal Space of the Rat. 12th Annual

and 1st International Scientific Session of the Academy of Surgical Research, Muenster,

Germany, October 3-5, 1996. Published in the Journal of Investigative Surgery, 1996, 9(3):

p 208.

77. Chen SA, Sawchuck RJ, Brundate RC, Horvath C, Mendenhall HV, Braeckman RA.

Plasma and Lymph Pharmacokinetics of Recombinant Interleukin-2 (IL-2) and

Polyethylene Glycol Modified IL-2 (PEG IL-2) in Female Pigs. National Meeting of the

American Association of Pharmaceutical Research, Seattle, Washington, October 12,

1996.

78. Mendenhall HV. Modern Methods of Anterior Cruciate Ligament (ACL) Repair. 53rd

Annual Conference of the Japanese Society of Veterinary Anesthesia & Surgery. Invited

Lecture. Morioka, Japan, November 2-3, 1996. Published in the Japanese Journal of

Veterinary Anesthesia & Surgery, 1996, 27 (Suppl 2): 2-10.

79. Mendenhall HV. A Clinically Applicable Animal Model for Evaluation of Bone Graft

Substitutes and Implantable Delivery Systems for Bone Repair. 53rd Annual Conference

of the Japanese Society of Veterinary Anesthesia & Surgery. Invited Lecture. Morioka,

Japan, November 2-3, 1996. Published in the Japanese Journal of Veterinary Anesthesia

& Surgery, 1996, 27 (Suppl 2): 11-18.

80. Mendenhall HV. Experimental Extracapsular Cataract (Lens) Removal and Posterior

Intraocular Artificial Lens (IOL) Implantation in Cynomolgus Monkeys with Reference to

Clinical IOL Implantation in Dogs. 53rd Annual Conference of the Japanese Society of

Veterinary Anesthesia & Surgery. Invited Lecture. Morioka, Japan, November 2-3, 1996.

Published in the Japanese Journal of Veterinary Anesthesia & Surgery, 1996, 27 (Suppl

2): 19-28.


As of April 6, 2015

81. Horvath C, Mendenhall HV, Piechowiak M, Wadanoli M. A Method to Allow for Direct

Administration of Test Articles to the Liver of Domestic Swine. 36th Annual Meeting,

Society of Toxicology. Cincinnati, Ohio, March 9-13, 1997.

82. Mendenhall HV, Piechowiak M, Wadanoli M, Horvath C. Surgical Catheterization of the

Urinary Bladder to Allow for Multiple Direct Infusions of Test Articles or Urine Collection

Over an Extended Period in Conscious Swine. 36th Annual Meeting, Society of Toxicology.

Cincinnati, Ohio, March 9-13, 1997.

83. Piechowiak M, Wadanoli M, Mendenhall HV, Horvath C: Surgical Catheterization of the

Urinary Bladder to Allow for Multiple Direct Infusions of Test Articles or Urine Collection

over an Extended Period in Conscious Rats. 36th Annual Meeting, Society of Toxicology.

Cincinnati, Ohio, March 9-13, 1997.

84. Wadanoli M, Piechowiak M, Mendenhall HV: Surgical Technique for Implantation of a

Urinary Catheter for Intracystic Delivery of Test Article and Sample Collection in the

Beagle. 36th Annual Meeting, Society of Toxicology. Cincinnati, Ohio, March 9-13, 1997.

85. Mendenhall HV Surgical Techniques in Device Testing, 1997 Technical Workshop,

Society for Biomaterials, New Orleans, Louisiana, April 30, 1997.

86 Mendenhall HV, Piechowiak M, Gamba-Vitalo C, Lilja H. Chronic Catheterization of the

Lateral Ventricle in Cynomolgus Monkeys. 1st International Conference of Asian Society

of Toxicology, Yokohama, Japan, June 29-July 2, 1997. Published in the Journal of

Toxicological Sciences, Vol 23, Supplement II, 1998, p 353.

87. Wadanoli M, Piechowiak M, Mendenhall HV, Lilja H. Instrumentation to Allow for

Long Term Intracystic Delivery of Test Articles and Urine Collection in the Conscious

Beagle Dog. 1st International Conference of Asian Society of Toxicology, Yokohama,

Japan, June 29-July 2, 1997.

88. Wadanoli M, Piechowiak M, Mendenhall HV, Lilja H. Instrumentation to Allow for

Long Term Intracystic Delivery of Test Articles and Urine Collection in the Conscious

Beagle Dog. Thirteenth Annual Scientific Session of the Academy of Surgical Research,

San Antonio, Texas, September 4-6, 1997.

89. Mendenhall HV, Piechowiak M, Wadanoli M, Horvath C: A Dual Implantable Urinary

Catheter System for Chronic Infusion and Urine Collection in Conscious Swine. Thirteenth

Annual Scientific Session of the Academy of Surgical Research, San Antonio, September

4-6, 1997.


As of April 6, 2015

90. Piechowiak M, Wadanoli M, Mendenhall HV, Horvath C: Surgical Instrumentation of Rats

to Allow for Chronic Direct Infusion into the Urinary Bladder over an Extended Period in

the Conscious Animal. Thirteenth Annual Scientific Session of the Academy of Surgical

Research, San Antonio, Texas, September 4-6, 1997.

91. Horvath C, Mendenhall HV, Piechowiak M, Wadanoli M. Long-Term Catheterization of

the Gastroduodenal Artery to Allow for Direct Administration of Test Articles to the Liver

in Conscious Yorkshire Swine. Thirteenth Annual Scientific Session of the Academy of

Surgical Research, San Antonio, Texas, September 4-6, 1997.

92. Mendenhall HV, Piechowiak M, Wadanoli M. Evaluation of BICCS® Bile Access System

in Beagle Dogs and Cynomolgus Monkeys. Access Technologies 1997 Laboratory Animal

Long-Term Access Roundtable, San Antonio, September 4, 1997.

93. Mendenhall HV, Piechowiak M, Wadanoli M, Raikowski D. A Long Term Study on the

Use of Vascular Access Ports in Multiple Species. Access Technologies 1997 Laboratory

Animal Long-Term Access Roundtable, San Antonio, September 4, 1997.

94. Mendenhall HV, Markham P. Bile Access System for Pharmacokinetics and Disposition

Studies in Nonhuman Primates and Dogs. Eighth North American International Society for

the Study of Xenobiotics, Hilton Head, South Carolina, October 26-30, 1997.

95. Sites JP, York TA, Hermann RP, Mendenhall HV. Systemic Perfusion Hyperthermia

techniques: control studies in canines. Veterinary Cancer Society/Society for Radiologic

Medicine, Chicago, IL, December, 1997.

96. Mendenhall HV. Selective Catheterization of the Internal Carotid Artery in Pigs.

Interventional Radiology Roundtable, in conjunction with the 14th Annual Meeting of the

Academy of Surgical Research, Nashville, Tennessee, October 1-3, 1998.

97. Mendenhall HV. Moderator, 3rd Annual Long-Term Access Roundtable in conjunction

with the 14th Annual Meeting of the Academy of Surgical Research, Nashville, Tennessee,

October 1-3, 1998.

98. Mendenhall HV. Bile Access in Monkeys. 3rd Annual Long-Term Access Roundtable in

conjunction with the 14th Annual Meeting of the Academy of Surgical Research.

Nashville, Tennessee, October 1-3, 1998.

99. Mendenhall, HV. Vascular Access Ports in General. 3rd Annual Long-Term Access

Roundtable in conjunction with the 14th Annual Meeting of the Academy of Surgical

Research, Nashville, Tennessee, October 1-3, 1998.


As of April 6, 2015

100. Mendenhall, HV, Markham P, Piechowiak M. Multiple Catheterization of the Internal Iliac

Vein and the Urinary Bladder to Allow for Assessment of Renal Function over Extended

Periods of Time in Conscious Cynomolgus Monkeys. 14th Annual Meeting of the Academy

of Surgical Research, Nashville, Tennessee, October 1-3, 1998.

101. Mendenhall HV. Surgical Techniques in Cardiovascular Device Testing. 7th International

Symposium, Cardiac Surgery in the 1990's. St. Thomas, USVI, November 4-8, 1998.

102. Mendenhall HV. Moderator, First European Laboratory Animal Long-Term Access

Roundtable, Amsterdam, the Netherlands, June 7, 1999.

103. Mendenhall HV. Update on the Use of Chronic Vascular Access Ports (VAPs) in

Laboratory Animal Species. First European Laboratory Animal Long-Term Access

Roundtable, Amsterdam, The Netherlands, June 7, 1999.

104. Mendenhall HV, Lane J, Sites JP. Techniques to Maximize Survival of Calves Undergoing

Cardiopulmonary Bypass. XII World Congress of International Society for Artificial

Organs and XXVI Congress of European Society for Artificial Organs. Edinburgh, UK,

August 3-6, 1999.

105. Mendenhall HV, Lane J, Sites JP. Techniques to Maximize Survival of Calves Undergoing

Cardiopulmonary Bypass. 15th Annual Meeting, Academy of Surgical Research, Scottsdale,

Arizona, September 2-4, 1999.

106. Mendenhall HV. Use of a Jejunal Intussuscepted “Nipple Valve” for Long-Term Intestinal

Access in the Yucatan Micro-Pig. 15th Annual Meeting, Academy of Surgical Research,

Scottsdale, Arizona, September 2-4, 1999.

107. Mendenhall HV. Radiographic Evaluation of Controlled Release Coatings Delivered

Directly to the Jejunum of Yucatan Micro-Pigs via a Jejunal Intussuscepted “Nipple

Valve”. 15th Annual Meeting, Academy of Surgical Research, Scottsdale, Arizona,


108. Duncan P.E., Mendenhall H.V., Hazard Analysis & Risk Assessment as a Tool for

PreClinical Study Planning. Medical Valley Workshop, Minneapolis, MN, February 9,

2000.

109. Mendenhall H.V., Techniques to Maximize Survival of Calves Undergoing

Cardiopulmonary Bypass. Seminar in Advances in Cardiovascular Testing, Society of

Toxicology, Philadelphia, Pennsylvania, March 19, 2000.


As of April 6, 2015

110. Duncan P.E., Mendenhall H.V., Hazard Analysis & Risk Assessment as a Tool for

PreClinical Study Planning. Corporate Forum, Sixth World Biomaterial Congress,

Kamuela, Hawaii, May 16, 2000.

111. Duncan P.E., Mendenhall H.V., Optimizing Study Design Through Risk Control: Animal

Study Planning for Clinical Trial Success. Corporate Forum, Sixth World Biomaterials

Congress, Kamuela, Hawaii, May 16, 2000.

112. Mendenhall, HV. Vascular Access Ports Overview: 1995-2000. Fifth Annual Laboratory

Animal Long-Term Access Roundtable, Cincinnati, Ohio, October 19, 2000.

113. Mendenhall HV. Hazard Analysis & Risk Assessment as a Tool for Pre-Clinical Study

Planning. Corporate Forum, 16th Annual Meeting, Academy of Surgical Research,

Cincinnati, Ohio, October 20, 2000.

114. Mendenhall HV. Hazard Analysis & Risk Assessment In Pre-Clinical Studies: The

Importance Of Asepsis, Surgical Technique And Choosing The Appropriate Animal

Model. 2001 Laboratory Animal Welfare Training Exchange (L.A.W.T.E.) Conference. St.

Louis, Missouri, August 2, 2001.

115. Mendenhall HV. The Biomechanics, Biochemistry and Pathophysiology of Synthetic

Augmentation of Soft Tissue, 17th Annual Meeting, Academy of Surgical Research, San

Diego, California, October 4, 2001.

116. Howk K, Mendenhall HV. A Model for Lateral Ventricular Drug Administration and

Cerebrospinal Fluid Collection Via Cranial Ports in Conscious Beagle Dogs. 17th Annual

Meeting, Academy of Surgical Research, San Diego, California, October 5, 2001.

117. Mendenhall, HV. Panel Member: “Bringing a Biomaterial-Based Product from the Bench

to the Clinic: Controversial Issues Along the Pipeline. Evaluation of Material Performance

(Animal Models)”. 28th Annual Meeting Society for Biomaterials, Tampa, Florida, April

26, 2002.

118. Mendenhall, HV. The Anesthesia, Pharmacological, and Adjunctive Surgical Management

of Thoracoabdominal Bypass Grafting in Pigs. 18th Annual Academy of Surgical Research,

Greenville, South Carolina, October 4th, 2002.

119. Bayer, K, Mendenhall, HV, Howk, K, LaRochelle, A. Continuous Infusion to the Lateral

Ventricle of the Beagle Dog. 18th Annual Academy of Surgical Research, Greenville, South

Carolina, October 4th, 2002.

120. Bayer, K, Pepin, M, Mendenhall, HV, LaRochelle, A. Catheterization of the Cerebral

Subarachnoid Space for Continuous Intrathecal Infusion in Sprague-Dawley Rats. 18th

Annual Academy of Surgical Research, Greenville, South Carolina, October 4th, 2002.


As of April 6, 2015

121. Mendenhall, HV, DesPlaines, D., Bayer, K., LaRochelle, A. Jugular and Femoral Vein

Vascular Access Ports (VAPs) in Pigs. 18th Annual Academy of Surgical Research,

Greenville, South Carolina, October 4th, 2002.

122. Mendenhall, HV, LaRochelle, A. The Use Of Implantable Pumps To Conduct Toxicity

Studies Involving Continuous Intracranial Infusion To Beagle Dogs. 19th Annual Academy

of Surgical Research, St. Louis, Missouri, October 3rd, 2003.

123. Mendenhall, HV, Cunningham, MR, Kellar, RS. Sternotomy as a Surgical Approach for

Studies Requiring a Second Thoracotomy in Dogs. 19th Annual Academy of Surgical

Research, St. Louis, Missouri, October 3rd, 2003.

124. Wright, TL, Smits, G, Mendenhall, HV. Effects of Medetomidine/Ketamine and

Thiobutabarbital on Selected Blood Gas Parameters in Anesthetized Rats. 19th Annual

Academy of Surgical Research, St. Louis, Missouri, October 3rd, 2003.

125. DesPlaines, D, Mendenhall, HV, Wilson, S, Cunningham MR. Implantation of the

Respiratory Telemetry Device in Beagle Dogs. 19th Annual Academy of Surgical Research,

St. Louis, Missouri, October 3rd, 2003.

126. Suganuma, A, Mendenhall, HV, Sites, JP, Kaneko, K, Nedelman, M, Kerns, WD. Safety

Evaluation of E5564, a Toll-like Receptor 4 (TLR4) Antagonist, on Cardiopulmonary

Bypass (CPB) Surgery in Dogs by Intravenous Infusion. 43rd Annual Meeting of the Society

of Toxicology, Baltimore, Maryland, March 23, 2004.

127. Bugelski, PJ, Martin, EC, Mendenhall, HV, Soderman. AR, Tam, SH, Picha, KM,

Khandekar, VS, Treacy, G. A humanized anti-tissue factor monoclonal antibody (CNTA

859) does not increase the risk of surgical bleeding in a cynomolgus monkey model. 43rd

Annual Meeting of the Society of Toxicology, Baltimore, Maryland, March 23, 2004.

128. Mendenhall, HV. Acid-Base Balance and Anesthetic Management in Cardiovascular

Surgery. Douglas M. Cromeens Memorial Keynote Address. 20th Annual Academy of

Surgical Research Meeting, Minneapolis, Minnesota, October 7-9, 2004.

129. Mendenhall, HV, Wilson, S, Coatney, B, Flegal, M. Implantation of the DSI Left

Ventricular and Direct Arterial Pressure Telemetry Transmitter. 20th Annual Academy of

Surgical Research Meeting, Minneapolis, Minnesota, October 7-9, 2004.

130. Mendenhall, HV. The Small Cow as an Animal Model for Lumbar Intervertebral Disc

Replacement. Podium Presentation. International Meeting on Advanced Spine Techniques,

Banff, Alberta, Canada, July 7-9, 2005.


As of April 6, 2015

131. Mendenhall, HV. Bilateral versus Unilateral Aorto-Iliac Vein Vascular Grafting in Swine.

21st Annual Academy of Surgical Research Meeting, Philadelphia, Pennsylvania,


132. Mendenhall, HV. The Small Cow as an Animal Model for Lumbar Intervertebral Disc

Replacement. Poster Presentation. 20th Annual Meeting, North American Spine Society,

Philadelphia, Pennsylvania, September 27-October 1, 2005.

133. Mendenhall, HV. A Combination of Intestinal Cannulation with a Jejunal Conduit for Long

Term Intestinal Cannulation in Mini-Swine. Johnson and Johnson Symposium on

Correlating Preclinical Models to Clinical Outcomes, Somerville, New Jersey, December

6-7, 2005.

134. Mendenhall, HV. Animal Models for Device Development for use in the Gastro-Intestinal

Tract. Johnson and Johnson Symposium on Correlating Preclinical Models to Clinical

Outcomes, Somerville, New Jersey, December 6-7, 2005.

135. Warnock, DF, Huibregtse, BA, Mendenhall, HV, Murphy, MP, Poff, BC. Model

Development for Evaluation of a Dialysis Access Graft. 22nd Annual Academy of Surgical

Research Meeting, Scottsdale, Arizona, September 21-23, 2006.

136. Mendenhall, HV. Cardiovascular Anesthesia Management—Keeping the animal

homeostatic for long and difficult procedures. SNEAALAS 2006 Year End Meeting.

Foxwoods Casino, Ledyard, CT, October 27, 2006.

137. Qiu, QQ, Mendenhall, HV, Garlick, D., Connor, J. DBM/AM Composite for Bone Repair.

53rd Annual Meeting of the Orthopedic Research Society, San Diego, California, February

11-14, 2007.

138. Mendenhall, HV. Preliminary Animal Testing for a Test Article’s Potential Efficacy in

Treating Adult Macular Degeneration. IBC’s 4th International Conference on Ocular Anti-

angiogenesis. Cambridge, Massachusetts, April 16-17, 2007.

139. Qiu, QQ, Mendenhall, HV, Garlick, DS, Connor, J. Evaluation of Bone Regeneration

within a Critical-Sized Defect in Athymic Rats Utilizing a DBM/AM Composite. Society

for Biomaterials 2007 Annual Meeting, Chicago, Illinois, April 18-21, 2007.

140. Mendenhall, HV. Surgical animal models of cardiovascular disease. AACC Animal

Division Spring Meeting on Animal Models of Human Disease, Bridgewater, New Jersey,

April 20, 2007.

141. Mendenhall, HV. Anesthetic Management in Cardiovascular Surgery. 2007 AALAS

Tribranch Symposium, Atlantic City, New Jersey, June 10-12, 2007.


As of April 6, 2015

142. Mendenhall, HV. Basic Surgical Knowledge: Principles & Practices. 21st Annual Charles

River Short Course on Laboratory Animal Science, Newton, Massachusetts, June 18-21,

2007.

143. Mendenhall, HV. The Rabbit as an Animal Model to Allow for Preliminary Testing for

Possible Treatments of Adult Macular Degeneration. 23rd Annual Academy of Surgical

Research Meeting, Clearwater Beach, Florida, September 27-29, 2007

144. Mendenhall, HV. The Principles and Practices of Experimental Surgery. 23rd Annual

Academy of Surgical Research Meeting, Clearwater Beach, Florida, September 27-29,

2007

145. Qiu, QQ, Mendenhall, HV, Garlick, DS, Connor, J. Bone Regeneration Induced by a

DBM/AM Composite within Critical-Size Calvarial Defects in Athymic Rats. 23rd Annual

Academy of Surgical Research Meeting, Clearwater Beach, Florida, September 27-29,

2007

146. Mendenhall, HV. Surgical Technique for Infusion of Potential Chemotherapeutic Agents

to the Liver via the Hepatic Artery. 58th AALAS National Meeting, Charlotte, North

Carolina, October 13-18, 2007.

147. Mendenhall, HV. Basic Surgical Knowledge: Principles & Practices. 22ndt Annual Charles

River Short Course on Laboratory Animal Science, Newton, Massachusetts, June 16-19,

2008.

148. Mendenhall, HV. Animal Models for Duraplasty Studies: Dog versus Swine. 2008 Annual

Meeting of the Congress of Neurological Surgeons, Orlando, Florida, September 20-25,

2008.

149. Mendenhall, HV, Abutin, R, Stricker-Krongrad, A. An Improved and Reliable Technique

for Determining the Efficacy of Dural Sealants. 2008 Annual Meeting of the Congress of

Neurological Surgeons, Orlando, Florida, September 20-25, 2008.

150. Mendenhall, HV. The Principles of Surgical Research. Plenary Lecture: 24th Annual

Meeting of the Academy of Surgical Research, Indianapolis, Indiana, November 6-8, 2008.

151. Mendenhall, HV. Aseptic Surgical Technique. 24th Annual Meeting of the Academy of

Surgical Research, Indianapolis, Indiana, November 6-8, 2008.

152. Mendenhall, HV, Abutin, R, Stricker-Krongrad, A. An Improved and Reliable Technique

for Determining the Efficacy of Dural Sealants. 24th Annual Meeting of the Academy of

Surgical Research, Indianapolis, Indiana, November 6-8, 2008.


As of April 6, 2015

153. Mendenhall, HV. Animal Models for Duraplasty Studies: Dog versus Swine. 24th Annual

Meeting of the Academy of Surgical Research, Indianapolis, Indiana, November 6-8, 2008.

154. Burke, SK, Franano, FN, LaRochelle, A, Mendenhall, HV. Local Application of

Recombinant Human Type I Pancreatic Elastase (PRT-201) to an Arteriovenous Fistula

(AVF) Increases AVF Blood Flow in a Rabbit Model. American Society of Nephrology,

41st Annual Meeting & Scientific Exposition, Philadelphia, Pennsylvania, November 4-9,

2008.

155. Burke, SK, Mendenhall, HV, LaRochelle, AW, Franano, FN. Recombinant Human

Pancreatic Elastase (PRT-201) Dilates the Arteriovenous Graft (AVG) Outflow Vein and

Increases Graft Blood Flow in a Porcine Femoral AVG Model. 6th International Congress

on Vascular Access, Rome, Italy, April 20-22, 2009.

156. Mendenhall, HV. An Overview of Critical Size Bone Defect Animal Models. 25th Annual

Meeting of the Academy of Surgical Research, New Orleans, Louisiana, September 24-26,

2009.

157. Baran, SW, Hallman TM, Kehler J, Mendenhall V, Perret-Gentil MI, Schantz JD, Johnson EJ.

Basic Principles of Rodent Surgery. Veterinary Bioscience Institute. January 2009.

http://vetbiotech.com/course.php?courseID=44

158. Burke SK, Blair A, Mendenhall HV, Stanley J, Groothuis A. Topical Elastase Increases

AVG Outflow Vein Diameter and Lumen Area in a Swine Model. Angioaccess for

Hemodialysis, Vascular Access Society, Tours, France, June 14-16, 2010.

159. Mendenhall HV. “Working” versus “Non-working” Heterotopic Heart Transplantation.

26th Annual Meeting of the Academy of Surgical Research, Clearwater Beach, Florida,

September 30-October 2, 2010.

160. Mendenhall HV, Bernal J, Moddrelle D. Cardiovascular Surgery in the non-human

primate. Techniques and Challenges. 61st AALAS National Meeting, Atlanta, Georgia,

October 10-14, 2010.

161. Mendenhall HV. Hazard and Risk Analysis: Pre-Clinical Study Planning (Animal Studies).

27th Annual Meeting of the Academy of Surgical Research, Austin, Texas, October 27-29,

2011.

162. Mendenhall HV. Anesthetic Management in Cardiovascular Surgery. 2012 Virtual

Laboratory Animal Science BioConference, February 15-16, 2012.

163. Mendenhall, HV. Practicing the Art of Surgical Research in the Development of New

Medical Devices and Pharmaceuticals. The Surgical Knowledge Exchange Seminar,

Collegeville, Pennsylvania, March 15, 2012.


As of April 6, 2015

164. Mendenhall HV. Lateral Ventricular Ports for Drug Administration or Cerebrospinal Fluid

(CSF) Collection in Canines and Non-Human Primates. The 2012 Turnkey Conference,

10th Annual Conference, Baltimore, Maryland, April 12-13, 2012.

165. Schroedter WB, Burke SK, Mendenhall VM, Blair A. Comparison of in-vivo arteriovenous

fistula volume flow measurements using a Transonic transit time ultrasound flow device

and Doppler ultrasound. Society for Vascular Ultrasound, 2012 SVU Annual Conference,

National Harbor, Maryland, June 7-9, 2012. D.E. Strandness, MD, Scientific Award for

Excellence in Research.

166. Pielemeier RT, Sweet J, Mendenhall HV, Geddings B, Adrian S, Almazan C, Ramsey H.

Critical Size Tibial Defect in Sheep: Notes on Improving Plating Techniques and Post-

Operative Management. 28th Annual Meeting of the Academy of Surgical Research,

Charlotte, North Carolina, October 3-6, 2012.

167. Mendenhall HV. Keynote Speaker: Practicing the Art of Surgical Research in the

Development of New Medical Devices and Pharmaceuticals. 28th Annual Meeting of the

Academy of Surgical Research, Charlotte, North Carolina, October 3-6, 2012.

168. Tawoda L, Pielemeier R, Mendenhall HV, Adrian S, LaBar M, Newell I, Rindfield T,

Wilson S, Johnson M. Achilles Tendon Repair: Development of a Surgical Technique for

Application of Biomaterials in a Rabbit Model. Society for Biomaterials, Fall Symposium,

New Orleans, LA, October 4-6, 2012.

169. Mendenhall HV. An Overview of Critical Size Bone Defect Animal Models. 2013 Virtual

Laboratory Animal Science BioConference, February 13-14, 2013.

170. Mendenhall HV. Utilization of the Swine Model within Translational Medicine for the

Development of New Cardiovascular and Wound Healing Therapies. The 2013 Turnkey

Conference, 11th Annual Conference, Baltimore, Maryland, April 16-17, 2013.

171. Mendenhall HV. Neurosurgical Animal Models. The 2013 Turnkey Conference, 11th

Annual Conference, Baltimore, Maryland, April 16-17, 2013.

172. Cunningham C, Baran SW, Douglas AT, Flynn DM, McCloud JE, Mendenhall HV.

Chostochondral Thoracotomy as a Means to Access the Left Ventricular Apex for

Intracardiac Injection in the Rat. 29th Annual Meeting of the Academy of Surgical

Research, Clearwater Beach, Florida, September 25-28, 2013.


As of April 6, 2015

173. Mendenhall HV, Giegengack M, Wagner BJ, McCloud JE, Flynn DM, Cunningham C,

Douglas AT. Technical Procedures Necessary to Achieve Successful Endothelial

Keratoplasty in the Cat. 29th Annual Meeting of the Academy of Surgical Research,

Clearwater Beach, Florida, September 25-28, 2013.

174. Goody R, Whittaker S, Henry S, Brookes R, Struharik M, Nisbett E, Morton X, Wilson C,

Mendenhall V, Lawrence M. Development of a chronic hypertension-induced model of

left ventricular hypertrophy and diastolic dysfunction in the St. Kitts green monkey.

NIH/NHLBI Symposium on Cardiovascular Regenerative Medicine, Natcher Conference

Center, Bethesda, MD, September 25-26, 2013.

175. Mendenhall HV. Surgical Animal Models of Cardiovascular Disease. Ask the Experts –

Achieving Successful Preclinical Cardiovascular Studies. Wake Forest Innovations

Seminar, October 29, 2013.

176. Mendenhall HV. Trials and Tribulations of the Refinement of Femoral Critical Sized

Defects in the Rat. 30th Annual Meeting of the Academy of Surgical Research, Minneapolis,

MN, September 18-20, 2014.

177. Mendenhall HV. Chronic Lymph Collection in the Canine. 30th Annual Meeting of the

Academy of Surgical Research, Minneapolis, MN, September 18-20, 2014.

178. Mendenhall HV. Surgical Technique to Allow for Single, Intermittent or Continuous

Infusion of Potential Chemotherapeutic Agents Directly to the Liver of Selected

Laboratory Animals via the Proper Hepatic Artery. 30th Annual Meeting of the Academy

of Surgical Research, Minneapolis, MN, September 18-20, 2014.

179. Mendenhall HV. Surgical Animal Models of Cardiovascular Disease. 30th Annual Meeting

of the Academy of Surgical Research, Minneapolis, MN, September 18-20, 2014.RCINE

FEMORAL A VG MODEL

h v mendenhall cv, 4 6-15

Healthcare

surgical component

surgical facility

surgical portion

biomedical surgical

nonclinical surgical

necessary surgical procedures

preclinical services

preclinical study designs