Hybrid Fluorescence Molecular Tomography - X-ray Computed Tomography method and system

• Project Overview and Updates

• Deliverables & Milestones

Veronika Erben

Project Overview

Titel: Hybrid Fluorescence Molecular Tomography - X-ray Computed Tomography method and systemAcronym: FMT-XCTCoordinator: Vasilis Ntziachristos (HMGU/TUM)Duration: March 01,2008 – February 28, 2012Funding: European Commission- FP7, € 4.5 Mio

http://www.fmt-xct.eu/

• Members only: Annex 1, Presentations, Reports …Username: fmt-xctPassword: eu_proj_2008

• Platform for data exchangeUpload/download of files at: http://www.fmt-xct.eu/transfer/User: fmt-xcttransfer, Login: get4data

Partners FMT-XCT

Report

Reporting Schedule4 Year Collaborative Project with 4 Reporting Periods

12 months

Mar

ch 01

,2008

Febru

ary 2012

Febru

ary 2011

Reporting: Financial & Activity report

Start

Febru

ary 2009

Febru

ary 2010

12 months 12 months 12 months

Half time report Report Final report

ReportingPeriod

1

ReportingPeriod

2

ReportingPeriod

3

ReportingPeriod

4+60

days

Report 1 accepted without any recommendations

Report 2 will be reviewed

New online tool Reporting Schedule4 Year Collaborative Project with 4 Reporting PeriodsNew online tool for reporting - ECAS

Every partner can register

Upload of all documents by HMGU

1.579.000€ Prefinancing 1+2

+ 557.000€ First interim payment (spent Year 1)

2.136.000€ (~ 50% of budget) received from EC (not spent)

Reporting Schedule4 Year Collaborative Project with 4 Reporting PeriodsFinances

EC pays up to 85% of the total budget (~ 3.8 m)

15% will be paid after acceptance of the final report (~700 k)

Reporting Schedule4 Year Collaborative Project with 4 Reporting PeriodsWork packages

TECHNICAL DEVELOPMENT IN-VIVO ALGORITHMIC TRAINING & PRE-CLINICAL IMAGING

Cancer imaging with focus on breast cancer imaging (Wp6)WP leader CEA-Lime

Imaging Cancer Therapy for enabling

intervention (Wp7)WP leader: UZH

MANAGEMENT (Wp1) WP leader: HMGU

Theory for 360 degree FMT (Wp3)WP leader: FORTH

FMT Inversion with priors (Wp4)

WP leader: UCL

FMT-XCT integration (Wp5)

WP leader: HMGU

TRAINING, DISSEMINATION &TECHNOLOGY TRANSFER (Wp9) WP leader: HMGU

XCT Development (Wp2)WP leader: CEA-Leti

FMT-XCT Imaging accurancy vs PET-XCT (Wp8)WP leader: FIHGM

Reporting Schedule4 Year Collaborative Project with 4 Reporting PeriodsAnimal models

Information for extension of Helmholtz animal protocols If available, please attach or cite already published literature of comparable studies

1.1 Background1.2 Description of the animal model

Name, strainOriginPreparationIn case of genetic modification, please also state whether this may result in any distress for the animal (in case yes, to which degree):

1.3 Imaging region1.4 Imaging probes (name; established/clinically approved; references)1.5 Injection1.6 Purpose 1.7 Number of experimental groups

1. Control untreated; 2. Contrast agent 1; 3. Contrast agent 2;1.8 Reference number of comparable foreign animal protocol (submission to):

Animal models should be integrated in animal protocols!

Deliverables Deliverables & Milestones

• Deliverables and milestones: once a year with report

• Year 1 (March 08- February 09): Report 1

• Year 2 (March 09- February 10): Report 2, April 6, 2010

• If not achieved please explain!

WP1 Management - WP leader HMGU

Deliverable No Name Month

1.1 Consortium Agreement March `08

1.2 Minutes of the kick off meeting March `08

1.3 Project website and updates Feb. `09, Feb. `10

1.4 Program of the consortium meeting Feb. `09

Milestone 1: Consortium Agreement March `08

1.3 Update project web site Feb. `11

1.4 Program of the consortium meetings Feb. `11

Year 1 (March 08 – Febr 09) Report 1

1.5 Half time report Feb. `10 /April `10

Year 2 (March 09 - Febr 10) Report 2

Year 3 (March 10 - Febr 11) Report 3

WP2 XCT Development WP Leader CEA-LETI

Milestone No 5 (mo 18= August 09): XCT dual energy vs. contrast enhancement

Deliverable No Name Month

2.2 Dual energy protototype May `09 Dec`09

2.3 Dual energy processing software May `09 Aug. `09

2.4 Preliminary technical specifications Nov `09

2.5 Scattered energy measurements Nov. `09

2.6 Comparison of contrast enhancement strategies Feb. `10

2.7 Final technical specification for XCT system Feb. `10

Deliverable No Name Month

2.1 XCT design (= Milestone 1) March ` 08 Nov ` 08

Year 1 (March 08 - Febr 09) Report 1

Year 2 (March 09 - Febr 10) Report 2

WP3 Theory for 360 degree FMTWP leader Forth

Milestone No. 4 (month 15 = May 09): Direct vs Conventional FMT performance

* New Deliverable „Ultra- fast Inversion for FMT“ month 24=Feb. 10

3.3 Quantitative evaluation of direct inversion with FMT data Aug. `09

3.4 Multi-spectral algorithm Nov. `09

3.5 User friendly software environment Feb.`10

Deliverable No Name Month

3.1 Direct inversion algorithm* Nov. `09

3.2 Experimental training set Feb. `09

3.6 Quantitative evaluation of direct inversion with hybrid FMT-XCT data

Oct. 2010

Year 1 (March 08 – Febr 09) Report 1

Year 2 (March 09 - Febr 10) Report 2

Year 3 (March 10 - Febr 11) Report 3

WP4: FMT inversion with image priors WP leader: UCL

Milestone No 6 (month 21 = Nov 09): Optimal FMT inversion with priors

4.1 Inversion algorithms for improving reconstruction May `09

4.2 Quantification of algorithmic performance with simulated data

Nov.`09

4.3 Inversion algorithms for estimating optical attenuation Feb.`10

4.4 An automatic feature extraction algorithm (= MS No7) Feb.`10

Deliverable No Name Month

4.1 Inversion algorithms for improving reconstruction Nov. `08

4.5 Quantification of algorithmic performance with experimental data Oct `10

4.6 User friendly software Feb. `11

Year 1 (March 08 – Febr 09) Report 1

Year 2 (March 09 - Febr 10) Report 2

Year 3 (March 10 - Febr 11) Report 3

WP5: FMT –XCT integration WP leader: HMGU

Milestone No 8 (mo 24 = Feb. `10) : FMT-XCT Shielding

5.2 Optimal settings May `09

5.3 Gantry development Feb. `10

Deliverable No Name Month

5.1 360 degree FMT prototype Feb. `09

5.4 FMT-XCT prototype May `10

5.5 Training data sets June `10

5.6 Multi- spectral capacity Aug. `10

5.7 Compute and assign optical attenuation values Oct. `10

5.8 Functional specification of optimal acquisition and operational parameters

Oct.` 10

5.9 Functional user-friendly operational software Feb. `11

Year

1Ye

ar2

Year

3

WP6: Cancer imaging with focus on breast cancer WP Leader: CEA Lime

6.2 - Lime Prepare mammary tumor animal models (lung and brain cancer) Aug. `09

6.3 - Lime Breed and make available PyMT animal models Feb. `10

Deliverable No Name Month

6.1 - Lime

To develop and characterize molecular probes Nov.`08

Milestone No10: FMT-XCT methodology for in-vivo quantification Oct. 2010

6.1 - Lime To develop and characterize molecular probes Aug. `10

6.4 - Lime Develop U87 animal models May `10

6.5 Study FMT-alone vs FMT-XCT in resolving tumors Feb.`11

i

Lime

Year

1Ye

ar2

Year

3

WP7: Imaging cancer therapy for enabling interventionWP leader: UZH

Deliverable No Name Month

7.1 Preparation of HIF transfected cancer cells Nov. 08

7.2 FMT of HIF induction of breast tumors May 09

7.3 FMT-XCT vs histological correlates in MDA-MB-231 tumors

Oct. `10

7.4 Lime FMT-XCT vs histological correlates in PyMt tumors Feb. `10

Milestone No 11: FMT-XCT methodology for quantified treatment imaging Feb. `11

i

Year

1Ye

ar2

Year

3

WP8: FMT-XCT imaging accuracy vs. PET-XCT WP leader: FIHGM

Deliverable No Name Month

8.1 Construct imaging phantoms Feb. `09

8.2 Phantom characterization with PET, FMT and XCT and appropriate probes

Feb.`10

8.3 Coregister and compare FMT-XCT and PET-XCT data Aug. `11i

Year

1Ye

ar2

Year

3

, WP9: Training & Dissemination WP leader: HMGU

Deliverable No Name Month

9.2 Training curriculum and implementation document

Feb.`10

2 Training sessions:1) Cea- Leti, Grenoble, 6th and 7th of July 2009: Advanced X-rays imaging techniques 2) UCL, London, 16-18 September 2009, Reconstruction methods

Deliverable No Name Month

9.1 Dissemination implementation document Feb.`11

9.3 Public promotion leaflet Feb.`11i

Next training session: Cea-Lime & UZH on animal models/cancer imaging October 2010

Year

2Ye

ar 3

Print outs available

Thank you for your attention!

Danke für Ihre Aufmerksamkeit!

Ευχαριστώ πολύ για την προσοχή σας!

Merci de votre attention !

Gracias por su atención !