haem biosynthesis ppt biochemistry [email protected]
TRANSCRIPT
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Heme metabolism Dr. Vijay Marakala, MBBS, MD.
Assistant professor BIOCHEMISTRY SIMS & RC
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Heme synthesis Heme
degradation
•Heme Metabolism
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•Heme synthesis
Hemoglobin Heme Pyrrole
Tetrapyrrole Porphyrinogen
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Haemoglobin
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Hemoglobin
Functions 1. Delivery of O2 from the lungs to the tissues2. Transport of CO2 from the tissues to the lungs.
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Haem •Heme is a member of a family of compounds called porphyrins.•Many important proteins contain heme as a prosthetic group.
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Porphyrins • Porphyrins are cyclic compounds composed of 4 pyrole rings held together by methenyl bridges.
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Porphyrins • Porphyrins are substituted at positions 1-8
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•Porphyrins
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•Porphyrins
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Site Reactions
Regulation
•Haem synthesis
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•Heme synthesis - site
Tissues
• Liver • Bone marrow
Cell
• Mitochondria • Cytoplasm
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•Reactions of Heme synthesisSTEPS ALA synthesis
Formation of PorphobillinogenFormation of HydroxymrthylbilaneFormation of UroporphyrinogenSynthesis of CoproporphyrinogenSynthesis of ProtoporphyrinogenGeneration of ProtoporphyrinGeneration of Heme
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ALA SYNTHASE
STEP 1
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PBG
δ ALA DEHYDRATASE
2 δALA STEP 2
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4 PBGSTEP 3
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STEP 4
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STEP 5
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3
4
5
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STEP 6
STEP 8
STEP 7
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Regulation of heme synthesis
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