HARUAN SPRAY FOR BURN AND WOUND

Prof. Saringat bin Bai @ BaieSchool of Pharmaceutical SciencesUniversiti Sains MalaysiaMinden 11800Penang, Malaysia

BACKGROUND

Haruan fish contains a lot of amino acids and fatty acids important to improve wound healing process

• At this moment , there are two types of Haruan preparation in the market to improve wound healing.

PROBLEM STATEMENT• Wound care films in the market:

- have limited size and singly packed can’t cover different sizes of wound- easily contaminated- difficult to use at certain part of body

• Majority of dressings for wound such as: plasters bandages cause pain during dressing Dressing pads and removal process

traumatic dressing

SOLUTION

Haruan Spray combination between a comfortable dressing for dermal wound and to provide an adequate nutrition to the wound site

NOVELTY AND USEFULNESS

• Can cover any size of wound• Ease of application and removal (water

washable)• Can protect the wound• Can heal the wound faster• Can replace skin graft• Product remain sterile

COMPETING PRODUCT• In spray dressing form:- OpSite- Nobecutane• In film dressing form:- Tegaderm- Omiderm- Bioclusive- Dermafilm- Etc.

COMMERCIALIZATION POTENTIAL

• Have an agreement with Major Interest Sdn.Bhd. to manufacture and marketing the product

• Market target: can be distributed to all over the world

RESEARCH FUND

• RU Grant of USM- 1 in 2007 : Formulation- 2 in 2009 : Wound healing test and Stability

study• TechnoFund• Innofund

IMPACT OF THE PRODUCT

• Increase human’s health for better quality of life

• Reduce the cost for patient’s ward at hospital after surgery

• As an alternative for diabetic wound treatment

ACADEMIC RECOGNITION

• Poster and oral presentation: 9• As invited speaker: 1• Published Journal: 3

Image at 0h Image at 2.5h

Image at 5h Image at 24h

Effect of haruan aqueous extract in migration of mouse fibroblast cells

Image at 0h Image at 2.5h

Image at 5 h Image at 24h

Effect of haruan aqueous extract in migration of human foreskin fibroblast cells

Irritation study of Haruan Spray in abraded and non abraded skin

Day 3 Day 6

Day 9 Day 12

Pictures of incision wound healing at day 0, 3, 6, 9, and 12

Day 0

Untreated Blank P1 P2

Day 3

Day 6

Day 15

Day 21

Photographs of burn wound at day 3, 6, 15 and 21 for control group (untreated), treated with blank, P1 (treated with haruan), P2 (treated with haruan+fusidic acid)

A B

C D

Photographs of histology study of burn wound treated with (A) blank, (B) haruan, (C) haruan+ fusidic acid, (D) untreated on day 7 (magnification 100x)

A B

C D

Photographs of histology study of burn wound treated with (A) blank, (B) haruan, (C) haruan+ fusidic acid, (D) untreated on day 14 (magnification 100x)

55 year old diabetic women got infected hand, operated and treated with CSKIN FIX cured after one month.

50 year old male diabetic patient, injured his leg and had gangrene to one of his finger, operated and treated with CSKINFIX , cure after one month. (1st Photo, two weeks in hospital, no improvement, 3rd Photo after one month treatment)

Won Silver Medal In 39th Geneva International Invention,6-9 April 2011