Cryogenic shipping from UPS

May 1, 2023

UPS Temperature True® Cryo, powered by CryoportSM

Proprietary and Confidential: This presentation may not be used or disclosed to any person other than employees of customer, unless expressly authorized by UPS.

© 2016 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 2

The biologics market is growing significantly.The global biologic drug market is estimated to grow 10% annually to nearly $300B by 2020

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© 2016 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 3

Changing demographics

The business need to diversify

A shift to chronic disease states

What’s driving growth?

Emergence of individualized medicine

Proprietary and Confidential: This presentation may not be used or disclosed to any person other than employees of

customer, unless expressly authorized by UPS. © 2016 United Parcel Service of America, Inc. UPS, the UPS

brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved.4

The business need to diversify

What’s driving the growth?

Proprietary and Confidential: This presentation may not be used or disclosed to any person other than employees of

customer, unless expressly authorized by UPS. © 2016 United Parcel Service of America, Inc. UPS, the UPS

brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved.5

Changing demographics: The aging population

What’s driving the growth?

Proprietary and Confidential: This presentation may not be used or disclosed to any person other than employees of

customer, unless expressly authorized by UPS. © 2016 United Parcel Service of America, Inc. UPS, the UPS

brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved.6

Emergence of individualized medicine

What’s driving the growth?

Proprietary and Confidential: This presentation may not be used or disclosed to any person other than employees of

customer, unless expressly authorized by UPS. © 2016 United Parcel Service of America, Inc. UPS, the UPS

brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved.7

What’s driving the growth? A shift to chronic

disease states

Proprietary and Confidential: This presentation may not be used or disclosed to any person other than employees of customer, unless expressly authorized by UPS.

© 2016 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 8

What’s driving the need for parcel solutions?

Specialized therapy areas

Visibility and intervention

High value Complex compliance

Patient experience is

crucial

Customs holdsSecurity

So, how willyou handle the challenges?

Proprietary and Confidential: This presentation may not be used or disclosed to any person other than employees of customer, unless expressly authorized by UPS.

© 2016 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved.

Can your current supply chain benefit from a turn-key parcel solution?

• Will it support cold chain needs?

• Will it prevent cellular degradation?

• Is it Safe? Secure? Reliable?

• Will it maintain product integrity, throughout the chain-of-custody?

• Is there complete visibility to enable shipment intervention?

• Is the network truly optimized?

• Will it support future growth and enable global market access?

• Will it flex and scale when you need to?

• Is it compliant and does it meet regulatory requirements?

Proprietary and Confidential: This presentation may not be used or disclosed to any person other than employees of customer, unless expressly authorized by UPS.

© 2016 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved.

Put your trust in a company that understands It’s a patient, not a package.®

Proprietary and Confidential: This presentation may not be used or disclosed to any person other than employees of customer, unless expressly authorized by UPS.

© 2016 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved.

UPS Temperature True® Cryo uses a robust web portal to provide a turnkey solution

Customers receive pre-charged dewars with

shipping documents to

conveniently move shipments

UPS moves and monitors shipment

using UPS Proactive

Response® and UPS Proactive

Response ® Secure

Customers place order on user-

friendly web portal to enable shipment

order entry, document creation

and tracking

PackagingLiquid nitrogen

dry vapor shipper

SecurityExpertise and system

support

TrackingLogistics management

platform

Proprietary and Confidential: This presentation may not be used or disclosed to any person other than employees of customer, unless expressly authorized by UPS.

© 2016 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved.

How to order UPS Temperature True® Cryo

How UPS Temperature

True® Cryo works

Order dewar online at ups.com/cryo

UPS delivers with preprinted labels; package and call for pickup

UPS picks up and delivers; return dewar using label

Dewar is sanitized, recharged and validated to reuse

Proprietary and Confidential: This presentation may not be used or disclosed to any person other than employees of customer, unless expressly authorized by UPS.

© 2016 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved.

Simplified biologics transportation

Reliable – 10+ days “dynamic” holding time without need for interventionDurable packaging – Designed for protecting fragile biologics during transportationStable Temperature Control – Consistent and stable cryogenic temperature below -1500 CelsiusIATA approved – International Air Transport Association (IATA) certified, non-hazardous and “green”Temperature Data & Reporting – Access to online temperature data and reporting; data stored in cloud-based portal

Temperature True® Cryo + UPS Proactive Response®

Visibility - Monitor packages 24/7 as they moves through our network Corrective Action – Initiate corrective action, if necessary based upon pre-defined recovery plans

Proprietary and Confidential: This presentation may not be used or disclosed to any person other than employees of customer, unless expressly authorized by UPS.

© 2016 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved.

Shipment monitoring and intervention

UPS Proactive Response® monitors progress• Provides earliest possible forecast of a delay• Experts can intervene to expedite delivery based on your instructions• Same-day, critical-courier service available if needed• UPS tracking and email alerts keep you up-to-date on arrival

UPS Proactive Response® Secure ensures protection• Provides shipment insurance and intervention

capabilities to ensure customer satisfaction

16Proprietary and Confidential: This presentation may not be used or disclosed to any person other than employees of customer, unless expressly authorized by UPS.

© 2016 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved.

When critical contents are on the move, there’s a lot on the line.

Trust UPS Temperature True® Cryo

“Powered by Cryoport” is a service mark of Cryoport, Inc.