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    Conductive Hearing Loss andCarharts Notch

    Mark Domanski, M.D.Tomoko Makishima, M.D., Ph.D

    University of Texas Medical Branch

    Department of OtolaryngologyGrand Rounds PresentationJune 4, 2008

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    Conductive Hearing Loss andCarharts Notch

    Physics of Sound Physics of Conductive Hearing

    Tympanogram and the Acoustic Reflex Physiopathology of Carharts Notch Diagnostic Implications of Carharts Notch

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    Conductive Hearing Loss andCarharts Notch

    Physics of Sound Physics of Conductive Hearing

    Tympanogram and the Acoustic Reflex Physiopathology of Carharts Notch Diagnostic Implications of Carharts Notch

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    Frequency Wavelength Period

    Amplitude Intensity Speed Direction

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    Frequency Wavelength Period

    Amplitude Intensity Speed Direction

    Cycles per second (Hz)

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    Frequency Wavelength Period

    Amplitude Intensity Speed Direction

    distance between repeating units ofa propagating wave

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    Frequency Wavelength Period Amplitude Intensity Speed Direction

    Implication of a repeating event

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    Frequency Wavelength Period Amplitude Intensity Speed Direction

    The amplitude is a nonnegativescalar measure of a wave'smagnitude of oscillation

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    Frequency Wavelength Period Amplitude Intensity Speed Direction

    intensity is a measure of the energyflux.

    "intensity" is not synonymous with"strength", "amplitude", or "level

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    Sound Intensity is Analogous toElectrical Flux

    If a point source is radiating energy in three dimensions and there is noenergy lost to the medium, then the intensity decreases in proportion todistance from the object squared

    http://web.ncf.ca/ch865/graphics/ElectricFlux

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    Frequency Wavelength Period Amplitude Intensity Speed Direction

    distance such a wave travels per unit time

    speed 770 mph, or 1130 ft/s) in dry air at70 degrees F

    speed of sound

    increases with the stiffness of the material decreases with the density

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    Frequency Wavelength Period Amplitude Intensity Speed Direction

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    Resonance:The tendency of a system to oscillate at maximum amplitude at certain frequencies

    Small periodic driving forces can produce largeamplitude vibrations

    If the monkey pushes the ball at the naturalfrequency (fundamental frequency) of the swing,the ball will go higher and higher

    resonanceno resonance

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    Haunted Swing

    http:// www.youtube.com/watch?v=l54W2gM-gYM

    http://www.youtube.com/watch?v=l54W2gM-gYMhttp://www.youtube.com/watch?v=l54W2gM-gYMhttp://www.youtube.com/watch?v=l54W2gM-gYMhttp://www.youtube.com/watch?v=l54W2gM-gYM
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    Pitch not an objective physical

    property

    a subjectivepsychophysical attribute

    perceived fundamentalfrequency of a sound

    perceived pitch may differbecause of overtones, orpartials, in the sound.

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    Timbre

    Why two guitars sound different even when they play thesame note

    the psychoacoustician's multidimensional wastebasketcategory

    S McAdams , A Bregman, Hearing Musical Streams, Computer Music Journal, 1979.

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    Sound Pressure Level

    As the human ear can detect sounds witha very wide range of amplitudes, sound

    pressure is often measured as a level on alogarithmic decibel scale.

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    Frequency Weighting

    human hearingsystem is moresensitive tosomefrequencies thanothers

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    Frequency Weighting

    humans hear random noisedifferently from pure tones

    D curve designed for measuringaircraft noise

    A weighting is most common

    C, B, frequency weighingcurves have fallen out of use

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    Sound level, loudness and soundintensity are not the same things

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    Conductive Hearing Loss andCarharts Notch

    Physics of Sound Physics of Conductive Hearing

    Tympanogram and the Acoustic Reflex Physiopathology of Carharts Notch Diagnostic Implications of Carharts Notch

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    Conductive Hearing Loss andCarharts Notch

    Physics of Sound Physics of Conductive Hearing

    Tympanogram and the Acoustic Reflex Physiopathology of Carharts Notch Diagnostic Implications of Carharts Notch

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    medicine.swu.ac.th/webmed/EL/Oph/doc/Conductive%20hearing%20loss-pleng.ppt

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    Purpose of ME

    To transmit sound energy from the airspace in the EAC to the fluid in the

    cochlea

    This is accomplished by vibration of the

    ossicles

    Adapted from The Acoustic Reflex, Richard W.Harris, Ph.D., Brigham Young University

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    So what if we didnt have a TM or any ossicles?

    most sound energy would bounce off the ovalwindow

    ~30 dB hearing loss

    Purpose of the TM and the ossicles is to eliminateIMPEDANCE MISMATCH Area advantage Lever advantage

    IMPEDANCE the resistance to flow of energy

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    Impedance Mismatch

    Pool

    sun

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    Area AdvantageTM

    OW

    Adapted from The Acoustic Reflex, Richard W.Harris, Ph.D., Brigham Young University

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    Area & Lever Ratio

    17 * 1.3 = _______

    therefore the overall increase in pressure equals:

    20 Log 22 = _________________

    22 to 1

    26.84 dB or 27 dB

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    Hearing by Bone Conduction

    1. Distortional2. Inertial Ossicular

    3. Osseotympanic

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    Distortional Conductive Hearing

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    Distortional Conductive Hearing

    Left: Cochlea at rest Middle: Cochlear duct is shortened vertically, causing an

    upward movement of the basilar membrane Right: Cochlear duct is heightened vertically, causing a

    downward movement of the basilar membrane

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    Distortional Conductive HearingCompression of the cochlea

    causes a downwardmovement of the basilarmembranes. This occursbecause the round window

    yields more than the oval window.

    Further downward movementof the basilar membranecauses deflection of thesteriocilia and stimulation ofthe auditory nerve.

    scala vestibuli

    scala tympani

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    Inertial Ossicular

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    Inertial Ossicular

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    Jerger-Liden Classifications

    A

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    Some Fluid or Ossicular Fixation

    AS

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    Ossicular Disarticulation, Atrophic TympanicMembrane Scarring

    AD

    Middle Ear Effusion TM Perforation

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    Middle Ear Effusion, TM Perforation,Cerumen Occlusion

    B

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    Negative Middle Ear Pressure

    C

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    The Acoustic Reflex

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    Normal Acoustic Reflex

    Impedance

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    Up to 40% Normal Persons

    Impedance

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    d d

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    Conductive Hearing Loss andCarharts Notch

    Physics of Sound Physics of Conductive Hearing Tympanogram and the Acoustic Reflex Physiopathology of Carharts Notch Diagnostic Implications of Carharts Notch

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    Uncertain Beginnings

    Miot in 1890 reported that he had usedKessels techniques to mobilize 200stapes without a single death or

    labyrinthine complication!

    1900: International Congress ofOtolaryngologists condemned stapessurgery because of the potential to causemeningitis

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    Knowledge Expands

    1916: Holmgren demonstrated that the labyrinthcould be safely opened with sterile techniques

    Raymond Thomas Carhart in 1950 first used theterm air-bone gap

    1953: Rosen accidentally mobilized the stapesof a patient under local anesthesia The patients hearing improved

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    Breakthrough Occurs

    1956 Shea, first stapedectomy with amicroscope

    1960, Shea inserted a Teflon piston into asmall fenestra

    1960, Schuknecht used a stainless steelwire prosthesis placed against Gelfoam toseal the oval window

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    Decline in Case Volume

    late 1970s: 1st publication recognizing adecline in stapedectomy cases ? backlog of surgical cases before 1960 that

    had been completed ? fluoride water

    ? immunization for measles virusVrabec, Jeffrey T.; Coker, Newton J. Otosclerosis , Otology & Neurotology.

    25(4):465-469, July 2004. Retrospective review of public records of population and case demographics

    S d P i

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    Stapedectomy Patients areGetting Older

    Evidence of Increased Average Age ofPatients with Otosclerosis

    Arnold W, Husler R (eds): Otosclerosis and Stapes Surgery.Adv Otorhinolaryngol. Basel, Karger, 2007, vol 65, pp 17-24

    Retrospective chart review

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    Incidence of Stapedectomies

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    Incidence of Stapedectomieshas Declined

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    Absolute # of Ear Surgeries

    Caughey, Robert J.; Pitzer, Geoffrey B.; Kesser, Bradley W. Stapedectomy:Demographics in 2006, Otology & Neurotology Volume 27(6), Sept. 2006, pp 769-775

    -retrospective review

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    Carharts Notch

    Carhart notch

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    Carharts Notch

    Elevation of bone conduction thresholds:~5dB at 4000Hz~10 db at 1000 Hz~15 db at 2000 Hz~5 db at 4000 Hz

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    Tonndorf

    Early 1970s Described ossicular inertial component

    of total bone conduction magnitude of the Carhart notch

    depended on the extent the middle earcontributed to the total bone conduction

    response in each of several species tested

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    Tonndorf

    Early 1970s frequency of the notch varied depending

    on the resonant frequency of theossicular chain for bone-conductedsignals. The resonant frequency of the human

    ossicular chain was at a relatively highfrequency compared with other species.

    lowest in cats and highest in rats.

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    Tonndorf

    Early 1970s Proposed that the Carhart notch peaks

    at 2,000 Hz due to the loss of the middleear component close to the resonancepoint of the ossicular chain

    Carharts Notch is Not Present in

    http://www.youtube.com/watch?v=QjrEkG870ko
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    Carhart s Notch is Not Present inEvery Patient with Otosclerosis

    Early otosclerosismay not affect theentire stapes

    footplate Cochlear

    otosclerosis can

    cause a SNHLcomponent

    Conductive Hearing Loss and

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    Conductive Hearing Loss andCarharts Notch

    Physics of Sound Physics of Conductive Hearing Tympanogram and the Acoustic Reflex Physiopathology of Carharts Notch Diagnostic Implications of Carharts Notch

    Conductive Hearing Loss and

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    Conductive Hearing Loss andCarharts Notch

    Physics of Sound Physics of Conductive Hearing Tympanogram and the Acoustic Reflex Physiopathology of Carharts Notch Diagnostic Implications of Carharts Notch

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    Yasan, 2007

    Carharts notch can appear in: otosclerosis primary malleus fixation otitis media with effusion

    Yasan, Predictive role of Carharts notch in pre -operative assessment formiddle-ear surgery. J. of Laryngology & Otology (2007), 121, 219-221.

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    Yasan, 2007

    Inclusion Criteria depression of bone

    conduction thresholdof > 10 dB at 0.5 4

    kHz frequencies CHL improved after

    surgery

    Exclusion Criteria Unsuccessfully

    operated ears (ie, > 20 dB air-bone

    gap)

    Ears with Carhartsnotch at > 4 kHz

    305 patientsretrospective chart review

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    Yasan, 2007

    Prevalence of patients with a condition whohave Carharts notch (at 1 or 2 kHz): Otosclerosis: 73 %

    Tympanosclerosis : 20 % Chronic otitis media: 12 % O.M.E.: 7.1%

    Ossicular anomaly 5.0%

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    Yasan, 2007

    If you have a Carharts notch in otosclerosisat 2kHz, you are likely to find a fixedstapedial footplate.

    Stapes footplate fixation present: 1 kHz 2 out of 11 patients 2 kHz 32 out of 37 patients

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    Yasan, 2007

    Mean magnitude of Carharts notch was16.44 +/- 4.35 dB

    Observed no specific relationship betweenmagnitude and middle ear pathologyobserved

    Quantifying the Carhart Effect in

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    Quantifying the Carhart Effect inOtosclerosis

    What is the effect?

    Problem You dont know the

    true bone

    threshold tillafterwards

    Cook, Krishnan, Fagan, Quantifying the Carhart Effect in Otosclerosis. Clin.

    Otolaryngol. 1995, 20, 258-261.

    Quantifying the Carhart Effect in

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    Quantifying the Carhart Effect inOtosclerosis

    Change in Bone conduction is partially dependent upon airbone gap closure. To model the effect of Carharts notch,we can express change in bone conduction as a functionof change in air conduction.

    dBC = change in bone conductiondAC = change in air conductionCC = frequency depended Carhart co-efficientK = frequency dependent constant

    ABGC = air-bone gap closure

    Pre Op Post Op

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    Pre OpBC 1 15

    air bone gap 25

    AC1 40

    Post OpBC2 5

    air bone gap 5

    AC2 10

    dBC

    dBC

    dBC

    ABCG

    Kcc

    dBC dBC

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    ABCG

    Kcc

    dAC

    Now we can do ourregression

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    Conclusion

    dBC

    dAC

    f

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    References Cook, Krishnan, Fagan, Quantifying the Carhart Effect in Otosclerosis. Clin.Otolaryngol. 1995, 20, 258-261.

    Yasan, Predictive role of Carharts notch in pre -operative assessment for middle-earsurgery. J. of Laryngology & Otology (2007), 121, 219-221.

    Yves Pelletier, Physics animations http://web.ncf.ca/ch865/graphics/ElectricFlux.jpeg www.homeschoolmath.net/worksheets/equation_editor.php The Acoustic Reflex, Richard W. Harris, Ph.D., Brigham Young University Vrabec, Jeffrey T.; Coker, Newton J. Otosclerosis, Otology & Neurotology. 25(4):465-

    469, July 2004. Arnold W, Husler R (eds): Otosclerosis and Stapes Surgery. Adv Otorhinolaryngol. Basel, Karger, 2007, vol 65,

    pp 17-24 Caughey, Robert J.; Pitzer, Geoffrey B.; Kesser, Bradley W. Stapedectomy:

    Demographics in 2006, Otology & Neurotology Volume 27(6), Sept. 2006, pp 769-775 Ohtani, Iwao; Baba, Yohko; Suzuki, Tomoko; Suzuki, Chiaki; Kano, Makoto,

    Otosclerosis, Otology & Neurotology. Why Is Otosclerosis of Low Prevalence inJapanese? 24(3):377-381, May 2003.Handbook of Clinical Audiology, 5 th Edition, Jack Katz, Baltimore, MD, 2002.

    http://web.ncf.ca/ch865/graphics/ElectricFlux.jpeghttp://www.homeschoolmath.net/worksheets/equation_editor.phphttp://www.homeschoolmath.net/worksheets/equation_editor.phphttp://web.ncf.ca/ch865/graphics/ElectricFlux.jpeg