Haemostasis  Testing  –  the  way  forward  

   Paul  Francis  Prem                                  Sr.  Manager  –  Business  Development    

                   Transasia  Bio-­‐Medicals  Ltd.      The   diagnostic   segment   today   comprises   a   wide   array   of   specialties.   With   the  availability  of  high  end  technologies,  it  is  possible  to  conduct  an  in-­‐depth  analysis  of  just  about  any  parameter.      Coagulation   remains   one   of   the  most   important   parts   of   diagnosis   in   pathology  and   is   routinely  suggested  as  a   first   line  test   for  disease  detection.   Ironically,   the  assay  is  still  restricted  to  only  PT/  ATT.  Evaluation  of  even  the  fibrinogen  level  (FIB)  is   considered   as   a   special   test.   Analyzers   available   in   the   market   offer   nothing  more   than   the   clot   based   tests   (PT/   ATT)   &   FIB   assays.  Moreover,   all   analyzers  available  in  India  work  on  the  principle  of  either  mechanical  or  optical  detection.    Mechanical  detection   is  an  age  old   technique  based  on  viscosity.   It   is  an   indirect  method   and   is   performed  with   a  metal   stirrer/bar/bead   in   the   reaction   cuvette.  The   latest   direct   measurement   method   is   based   on   the   optical   scatter   light  (nephlometry)  principle  and  makes  use  of  clear  reagents.  This  method  offers  much  more  information  on  clot  formation  than  its  predecessor.      Opening  doors  beyond  routine  Coagulation  Transasia   Bio-­‐Medicals   Ltd.   has   committed   itself   to   offering   the   latest,   highest  quality  systems  across  the  globe  for  over  thirty  five  years  now.  Understanding  the  customer   needs   and   going   beyond   limitations   to   provide   the   best   solutions,   has  been  its  forte,  earning  it  credibility  globally.      Transasia,  alongwith  its  subsidiary  ERBA  Diagnostics,  France,  has  developed  a  new  semi-­‐automated  system-­‐  ECL  series.  ECL  105  (single  channel  analyzer)  and  ECL  412  (four   channel   analyzer)   are   capable   of   performing   all   clot,   chromogenic   and  immunotubidometric   assays   (haemostasis).   These   systems   employ   the   most  advanced  and  trusted  nephlometry  principle  for  detection.  The  innovative  ECL  412  is   the   only   system   of   its   kind   to   perform   the   complete   hemophilia   and  

thrombophilia  panels.  The  wider  test  menu  provides  an  edge  over  all  the  routine  systems.  The  measurement  of  clots  at  640nm  is  the  first  of  its  kind  to  measure  HIL  samples.   Moreover,   the   multi-­‐channel   operations   on   ECL   412   enhances   the  parallel   run   of   either   the   duplicate   or   fresh   assays,   thereby   increasing   the  throughput.    

   The   system   is   capable   of   providing   better   calibration   data   for   every   parameter,  resulting  in  higher  accuracy  of  reporting.  The  large  graphical  display  aids  in  viewing  the   reaction   curve   for   the   assay   and   analyzing   the   data   in   correlation   with   the  results.    The   system   uses   half   the   volume   of   reagents   required,   thereby   making   it   cost  effective  with  better  precision.      Today,  most   laboratories  are  accredited  and  have  started  using  LIS.  ECL  provides  for  LIS  compatibility  and  data  export  system.  Vis-­‐à-­‐vis   its  counterparts,   it  offers  a  

wider   data   storage   capacity,   an   expandable  memory   and   provision   for   interface  and  transfer  of  information.      The   system   is   complimented   with   a   validated,   high   quality,   economically   priced  range  of  reagents  provided  by  Transasia.  By  far,  the  most  advanced,  the  ECL  series  along  with  its  reagent  range,  provide  much  beyond  the  clot  based  assays,  offered  by  all  other  semi-­‐automated  analyzers  in  the  market.  With  its  unmatched  services,  the  system  is  best  suited  to  serve  not  just  standalone  labs  but  corporate  hospitals,  chain  labs  and  referral  labs  as  well.    All   in   all,   the   system   offers   all   test   features   of   a   fully   automated   coagulation  analyzer  on  a  semi  automated  system.