Pathology of Viral HepatitisMuhammad Natsir Ilvira1008260053FK UMSU

Hepatitis-*Shashi-*

Introduction:Inflammation of LiverViral, immune, Drugs, Toxins & other.Acute, Chronic & Fulminant - typesViral Hepatitis Specific Hepatitis A, B, C, D, E, & other Systemic - CMV, EBV, other.

Hepatitis-*Shashi-*

Phases of Hepatitis :Carrier state / Asymptomatic phaseAcute hepatitisChronic HepatitisChronic Persistent HepatitisChronic Active HepatitisFulminant hepatitisCirrhosis

Hepatitis-*Shashi-*

Acute Hepatitis:Incubation phase.Symptomatic pre-icteric / prodromal phase.Symptomatic icteric phase.Convalescence.

Hepatitis-*Shashi-*

Typical Serologic HepB Course

Weeks after ExposureTiterSymptomsHBeAganti-HBeTotal anti-HBcIgM anti-HBcanti-HBsHBsAg0481216202428323652100

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Hepatitis-*Shashi-*

Acute ChronicBallooning deg.CholestasisApoptosisPeriportal NecrosisMacrophagesInflammationPortal inflammationFatty change(C)Ground class (B)ApoptosisPeriportal NecrosisMacrophagesPortal Lymphoid infiltrateBridging fibrosisFatty change(C)

Hepatitis-*Shashi-*

Fulminant Hepatitis:Hepatic failure with in 2-3 weeks.Reactivation of chronic or acute hepatitisMassive necrosis, shrinkage, wrinkledCollapsed reticulin networkOnly portal tracts visibleLittle or massive inflammation timeMore than a week regenerative activityComplete recovery or - cirrhosis.

Hepatitis-*Shashi-*

Hepatitis Morphology

Hepatitis-*Shashi-*

Hepatitis viruses:(A,B,C,D,E,G & other)

VirusHep-AHep-BHep-CAgentssRNAdsDNAssRNATransm.Feco-oralParenteralParenteralCarrier stateNone0.1-1.0%0.2-1.0%Chronic HepatitisNone5-10%>50%

Hepatitis-*Shashi-*

Concentration of Hep B Virus in Various Body Fluids

HighModerateLow/NotDetectablebloodsemenurineserumvaginal fluidfeceswound exudatessalivasweattearsbreastmilk

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Hepatitis-*Shashi-*

Liver Gross Cirrhosis

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