hepatosys – program and mission jens timmer speaker of the project-committee of hepatosys
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HepatoSys – Program and Mission
Jens Timmer
Speaker of the Project-Committee of HepatoSys
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One large German-wide project ?
Join an European initiative ?
Local centres ?
Several medium sized projects ?
How to spend XX Mio. € for Systems Biology ?
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Decision of the German Federal Ministry for Education and Research:
One large German-wide project: HepatoSys
Join an European initiative: SysMO
Local centres: Four Research Units for Systems Biology
Several medium sized projects: MedSysBio
How to spend XXX Mio. € for Systems Biology ?
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2001-2003: Preparation
2004-2006: First funding period: “Getting Started”
2007-2009: Second funding period: “Integration”
The History of HepatoSys
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Advisory board
Definition of Systems Biology
Choice of cell system: Primary hepatocytes
Structure of HepatoSys
2001-2003: Preparation
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Two „Networks”
- Regionally organised
- Concentrating on specific topics
- Comprise dry & wet labs
Two „Platforms“
- German-wide organised
- One for Cell Biology, one for Modelling
Preparation: Structure of HepatoSys
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Two Networks :
Network Regeneration: Freiburg, Heidelberg
Signalling networks
Network Detoxification/Dedifferentiation: Stuttgart
Metabolic networks
Two Platforms :
Platform Cell Biology: All over Germany
Standardised cell material, supply with human hepatocytes
• Platform Modelling: Berlin, Magdeburg, Heidelberg
General methods, cooperations with Networks
2004-2006: First Funding Period
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First Funding Phase: “Getting Started”
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Standardisations
A number of wet lab groups switching to hepatocytes
A lot of meetings and communication
Cooperations between people who never met before
A change in culture
HepatoSys is more than the sum of its parts
Achievements of First Funding Period
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Standardisation Klingmüller U., Bauer A., Bohl S., Nickel P., Breitkopf K., Dooley S., Zellmer S., Kern C., Merfort I, Sparna T., Donauer J., Walz G., Geyer M., Kreutz C., Hermes M., Götschel F., Hecht A., Walter D., Egger L., Neubert K., Borner C., Brulport M., Schormann W., Sauer C., Baumann F., Preiss R., MacNelly S., Godoy P., Wiercinska E., Ciuclan L., Edelmann J., Kleemann W.J., Zeilinger K., Heinrich M., Zanger U.M., Reuss M., Bader A., Gebhardt R., Maiwald T., Timmer J., von Weizsäcker F., Hengstler J.G.Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways. IEE Proc. Systems Biology 153, 2006, 433-447
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Two new Networks
Endocytosis: Dresden, Mannheim, Aachen, Hamburg
Iron Regulation: Berlin, Heidelberg
Motto: “Integration”
Integration of parts of Platforms into Networks
Integration of Modules into Processes
2007-2009: Second Funding Period
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The Structure of HepatoSys
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Cooperations of HepatoSys
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Putting all the ‘omics together
So far: large scale, qualitative
Understanding biomedical systems by data-based
mathematical modelling of their dynamic behaviour
So far: small scale, quantitative
Two Definitions of Systems Biology
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Convergence of the two approaches:
Large scale, quantitative
Integrated mathematical models of central functions of
hepatocytes:
Detoxification of xenobiotics
Proliferation after liver damage
Metabolic regulation of homeostasis
“Virtual hepatocyte”
Goals of HepatoSys
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Clinical & pharmaceutical implications:
Personalised medicine
Efficient model-based drug targeting
Improved strategies for liver regeneration
Less animal experiments
Improved iron-substitution therapies
Mission of HepatoSys
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August 27, 2008, Gothenburg
Workshop “Systems Biology of the Liver” at ICSB 2008
http://sysbio.uni-freiburg.de/Workshop_Liver_ICSB08.html
Towards HepatoSys-worldwide
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Our Steering Committee:
Hans Westerhoff (Chair)
Siegfried Neumann (Vice-Chair)
Roland Eils
Jan Hoek
Uwe Sauer
Marius Üffing
Thanks to
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Federal Ministry for Education and Research
Special thanks to „Projektträger Jülich”:
Gisela Miczka
Erich Stüttgen
Thanks to