hg9u^ rf - iu.a.u-tokyo.ac.jp · ",1 zxmg~ d gwas ",0) /6* #37 =| é )ø § Ð p q...

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",1zXMg~D GWAS",0)/6*#37 čĽ| éĩøĈ§Ð pq'##37@m 2 Yang et al. (2003) Am. J. Hum. Genet 73: 627 ACTN3+¹*<BNj¤¸MjZBÑα-ctinin-3:ES$7 <efX+ÖÉESj)4!$α-ctinin-3Ä7&%( a-actinin-3*đ+a-actinin-2)4!$į87ACTN3*Įùç*· 5ęn(7&®98$

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Page 1: hG9u^ Rf - iu.a.u-tokyo.ac.jp · ",1 zXMg~ D GWAS ",0) /6* #37 =| é )ø § Ð p q '# #37@m 2 Yang et al. (2003) Am. J. Hum. Genet 73: 627 •ACTN3+ ¹ *

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Yang et al. (2003) Am. J. Hum. Genet 73: 627

• ACTN3+�¹��*<BNj¤¸MjZBÑα-ctinin-3:E�S�$�7• <efX+�ÖÉESj)4!$α-ctinin-3�Ä7�&�%�(�• a-actinin-3*đ�+a-actinin-2)4!$į��87��ACTN3*Įùç*·��5�ę�n(7&®98$��

Page 2: hG9u^ Rf - iu.a.u-tokyo.ac.jp · ",1 zXMg~ D GWAS ",0) /6* #37 =| é )ø § Ð p q '# #37@m 2 Yang et al. (2003) Am. J. Hum. Genet 73: 627 •ACTN3+ ¹ *

126,559i�*�(�E��\dC��GWAS

• Fig. 1*3"*SNPs+��*¯�ėÏęŊ('&*<LG?�Gcj%2¦Ý�8��Rietveld et al. 2014, PNAS 13790, Ward et al. 2014 PLoS ONE e100248)

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Rietveld et al. (2013) Science 340: 1467

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Page 3: hG9u^ Rf - iu.a.u-tokyo.ac.jp · ",1 zXMg~ D GWAS ",0) /6* #37 =| é )ø § Ð p q '# #37@m 2 Yang et al. (2003) Am. J. Hum. Genet 73: 627 •ACTN3+ ¹ *

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Page 4: hG9u^ Rf - iu.a.u-tokyo.ac.jp · ",1 zXMg~ D GWAS ",0) /6* #37 =| é )ø § Ð p q '# #37@m 2 Yang et al. (2003) Am. J. Hum. Genet 73: 627 •ACTN3+ ¹ *

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“The most dramatic response to genomic selection was observed for the lowly heritable traits DPR, PL, and SCS. Genetic trends changed from close to zero to large and favorable, resulting in rapid genetic improvement in fertility, lifespan, and health in a breed where these traits eroded over time.”

Page 5: hG9u^ Rf - iu.a.u-tokyo.ac.jp · ",1 zXMg~ D GWAS ",0) /6* #37 =| é )ø § Ð p q '# #37@m 2 Yang et al. (2003) Am. J. Hum. Genet 73: 627 •ACTN3+ ¹ *

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Page 6: hG9u^ Rf - iu.a.u-tokyo.ac.jp · ",1 zXMg~ D GWAS ",0) /6* #37 =| é )ø § Ð p q '# #37@m 2 Yang et al. (2003) Am. J. Hum. Genet 73: 627 •ACTN3+ ¹ *

BO for genomic screening of plant germplasm

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Page 7: hG9u^ Rf - iu.a.u-tokyo.ac.jp · ",1 zXMg~ D GWAS ",0) /6* #37 =| é )ø § Ð p q '# #37@m 2 Yang et al. (2003) Am. J. Hum. Genet 73: 627 •ACTN3+ ¹ *

sAF���@myi = u+β j xij + ei

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Page 8: hG9u^ Rf - iu.a.u-tokyo.ac.jp · ",1 zXMg~ D GWAS ",0) /6* #37 =| é )ø § Ð p q '# #37@m 2 Yang et al. (2003) Am. J. Hum. Genet 73: 627 •ACTN3+ ¹ *

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Page 9: hG9u^ Rf - iu.a.u-tokyo.ac.jp · ",1 zXMg~ D GWAS ",0) /6* #37 =| é )ø § Ð p q '# #37@m 2 Yang et al. (2003) Am. J. Hum. Genet 73: 627 •ACTN3+ ¹ *

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Page 10: hG9u^ Rf - iu.a.u-tokyo.ac.jp · ",1 zXMg~ D GWAS ",0) /6* #37 =| é )ø § Ð p q '# #37@m 2 Yang et al. (2003) Am. J. Hum. Genet 73: 627 •ACTN3+ ¹ *

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Page 11: hG9u^ Rf - iu.a.u-tokyo.ac.jp · ",1 zXMg~ D GWAS ",0) /6* #37 =| é )ø § Ð p q '# #37@m 2 Yang et al. (2003) Am. J. Hum. Genet 73: 627 •ACTN3+ ¹ *

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Page 12: hG9u^ Rf - iu.a.u-tokyo.ac.jp · ",1 zXMg~ D GWAS ",0) /6* #37 =| é )ø § Ð p q '# #37@m 2 Yang et al. (2003) Am. J. Hum. Genet 73: 627 •ACTN3+ ¹ *

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Page 13: hG9u^ Rf - iu.a.u-tokyo.ac.jp · ",1 zXMg~ D GWAS ",0) /6* #37 =| é )ø § Ð p q '# #37@m 2 Yang et al. (2003) Am. J. Hum. Genet 73: 627 •ACTN3+ ¹ *

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• RKHSw�Crossa et al. (2010) Genetics 186: 713*@jd>jËņ)R\hCd` 6�

Äĩ)��7GSÓIJêĎĠ�)��$+Zhong et al. (2009) Genetics 182: 355Crossa et al. (2010) Genetics 186: 713Iwata and Jannink (2011) Crop Sci 51: 1915Heffner et al. (2011) Crop Sci 51: 2597('