high output gastrointestinal fistula management
TRANSCRIPT
High output gastrointestinal fistula management
B86401103Ri 烏惟新
Definition Fistula:
Abnormal pathological communication between two epithelialized surfaces.
Categorization Anatomical Physiological Etiological
Anatomy External Internal Proximal Distal Simple Complicated
Physiology High-output fistula
Pancreatic fistulae >200 ml/24 hours
Intestinal fistulae >500 ml/24 hours
Low-output fistula Pancreatic fistulae
<200 ml/24 hours Intestinal fistulae
<500 ml/24 hours
Etiology Abdominal surgical procedure
Leading cause, 67-85% Inflammatory bowel disease Diverticular disease Malignancy Radiation enteritis Trauma Congenital Other causes
Abdominal surgical procedures Predisposing factor
Cancer Inflammatory bowel disease Lysis of adhesions Peptic ulcer Pancreatitis Emergency Technical failure
Complications Loss of GI contents
Hypovolemia Acid-base and electrolyte abnormalities
Malnutrition Lack of food intake, loss of protein in fistula
discharge, hypercatabolism associated with sepsis
Sepsis Skin excoraiation Hemorrhage Psychological effect
High output fistula Fistula output
A predictor of morbidity and mortality Not an independent indicator of
spontaneous closure Fistula mortality rates have decreased
over the past few decades from as high as 40–65% to 5.3–21.3%
High output fistulae continue to have a mortality rate of approximately 35%.
Clinical/physical signs Slow or unusual course of post-
operative recovery Abdominal pain or tenderness Fever, and leukocytosis Skin:
Cellulitic appearance Excessive drainage Abscess formation
Evaluation History Physical examination Radiographic studies Laboratory studies
Image study Contrast radiography
fistulography, oral contrast , contrast enema, pyelography, cystography
Endoscopy Abdominopelvic CT scan, MRI,
ultrasound X-ray
Management Conservative
Fluid resuscitation Correct acid-base and electrolyte abnormalities Complete bowel rest Nutritional support Infection control Fistula drainage Skin protection
Surgery
Fluid resuscitation Correct hypovolemia Accurate measurement of ongoing
fluid losses Intravenous fluid administration
Iso-osmotic and high in potassium Replaced with a balanced salt
solution that contains added potassium
Sample of fistula fluid
Correct acid-base and electrolyte abnormalities Site of the fistula Quantity of fluid loss
High-output gastric fistulas Hydrochloric acid
Biliary and pancreatic fistula Hypertonic Large bicarbonate and sodium losses
Complete bowel rest Reduce fistula drainage
Solid food stimulates secretion of digestive juices and therefore
increases fistula output, exacerbating poor nutritional status and limiting healing
Simplify the evaluation
Nutritional support Early, aggressive parenteral
nutritional therapy has dramatically decreased mortality from fistulas from 58% to 16% (am J surg 108:157, 1964).
Therapeutic role Decrease in fistula output Modify the composition of
gastrointestinal pancreatic secretions
Role of TPN Conservative treatment with TPN
Reduce the maximal secretory capacity of the gastrointestinal tract by 30–50%
Not suppress basal or cephalic secretions Long term administration the presence of
lipids and amino acids can stimulate GI secretions
TPN complications Bacterial translocation, superinfection of
central venous access, and metabolic disorders as a result of fistula losses
Nutritional support Enteral feeding
Primary method of choice Esophagus, distal ileum, and colon Given below proximal fistula if accessible
Parenteral nutrition Intolerance to enteral nutrition Gastroduodenal, pancreatic, or jejuno-ileal
fistulae Proximal fistulas if distal enteral access is not
possible Reinfusion into the distal bowel
Infection control Intraabdominal abscess Intravenous antibiotics Infected wounds
Fistula drainage Wound management
Dressings Intubation Suction or sump drainage system
Pharmacotherapy Octreotide H2-receptor antagonists
Skin protection Barrier device Powder Examined and cleansed frequently
Surgical treatment Fistulas fail to heal with
nonoperative measures Sepsis cannot be controlled
Spontaneous closure unlikely.. FRIEND
Foreign body Radiation injury Inflammatory bowel disease Epithelialization of fistular tract Neoplasia Distal obstruction
Unfavourable Favourable
Lateral fistula End fistula
Large adjacent abscess No associated abscess
Adjacent bowel diseased Adjacent bowel healthy
Distal obstruction Free distal flow
Fistula tract <2 cm — epithelialisation
Fistula tract >2 cm — non-epithelialised
Enteral defect >1 cm Enteral defect <1 cm
Fistula site:• Gastric• Lateral duodenal• Ligament of Treitz• Ileal
Fistula site:• Oropharyngeal• Esophageal• Duodenal stump• Pancreatobiliary• Jejunal
High output fistula High morbidity and mortality Strategy to reduce both output
volume and the content of corrosive enzymes in the exudate would be likely to decrease the healing time, greatly improving prognosis
Somatostatin-14 in combination with TPN Accelerated spontaneous closure of postoperative
gastrointestinal fistulae, significantly reducing the required period of TPN treatment (time to healing 13.9±1.84 days somatostatin-14+tpn v 20.4±2.98 days TPN alone; N=20, respectively; Ph0.05) with a consequent reduction in morbidity (35% somatostatin-14+tpn v 68.85% TPN alone; Ph0.05).
Inhibit both basal and stimulated digestive secretion, as well as reducing fluid loss, electrolyte imbalance, and malnutrition, leading to potential reductions in fistula output and time to closure.
Mechanisms of octreotide Inhibits the release of gastrin,
cholecystokinin, secretin, motilin, and other GI hormones. Decreases secretion of bicarbonate, water, and
pancreatic enzymes into the intestine, subsequently decreasing intestinal volume.
Relaxes intestinal smooth muscle, thereby allowing for a greater intestinal capacity.
Increases intestinal water and electrolyte absorption
Reasons for pharmacotherapy Rapidly reduce fistula output
Improvement in nutritional and electrolyte status Reduction of the concentration of caustic enzymes
in the discharge will convey beneficial effects on both wound healing and nutritional losses
Significantly shorten healing time Shortening hospitalisation Improvements in quality of life Reductions in overall treatment costs
However, lacking data from large scale, double blind, randomised, controlled studies
Guideline:Somatostatin use
Guideline:GI fistulamanagement
Summary:high output GI fistula management Early detection Stabilize the patient
Aggressive fluid resuscitation Electrolyte and acid-base balance Nutrition support and bowel rest Control infection Drainage and skin protection
Evaluation the status and prognosis factor Try pharmacotherapy Surgical treatment if needed
Reference The Washington Manual of Surgery, 2nd ed. Feldman: Sleisenger & Fordtran's
Gastrointestinal and Liver Disease, 7th ed Optimising the treatment of upper
gastrointestinal fistulae, I González-Pinto and E Moreno GonzálezGut 2001; 49 (Suppl 4): iv21-iv28
The relevance of gastrointestinal fistulae in clinical practice: a reviewM Falconi and P PederzoliGut 2001; 49 (Suppl 4): iv2-iv10
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