hiv-infection in russia alexander panteleev head of the hiv/tb department city tb hospital # 2,...

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HIV-infection in Russia Alexander Panteleev Head of the HIV/TB department City TB Hospital # 2, St- Petersburg, Russia

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Page 1: HIV-infection in Russia Alexander Panteleev Head of the HIV/TB department City TB Hospital # 2, St-Petersburg, Russia

HIV-infection in Russia

Alexander PanteleevHead of the HIV/TB department

City TB Hospital # 2, St-Petersburg, Russia

Page 2: HIV-infection in Russia Alexander Panteleev Head of the HIV/TB department City TB Hospital # 2, St-Petersburg, Russia

Prevalence of HIV in Russia and in St-Petersburg 1998-2008, per 100.000 population

7 1954 106 130 147 159

230 238 269307

8 17133

367435

461560

624644

688

763

0

200

400

600

800

1000

1200

1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008

St-PetersburgRussia

Page 3: HIV-infection in Russia Alexander Panteleev Head of the HIV/TB department City TB Hospital # 2, St-Petersburg, Russia

Transmission of HIV infection 1987-2008 St-Petersburg, Russia

0

67

818189

65

54

72

9797

70

1717

8101613

713

26

96

0

10

20

30

40

50

60

70

80

90

100

87-95 96-99 2000 2001 2002 2003 2004 2005 2006 2007 2008

parenteral sexual

%

St. Petersburg City AIDS Centre

Page 4: HIV-infection in Russia Alexander Panteleev Head of the HIV/TB department City TB Hospital # 2, St-Petersburg, Russia

Incidence of TB in Russia 1992-2008per 100.000 population

Ministry of health Russia, 2008

Page 5: HIV-infection in Russia Alexander Panteleev Head of the HIV/TB department City TB Hospital # 2, St-Petersburg, Russia

Two epidemics in Russia

HIV

HIV

TB

TB

Page 6: HIV-infection in Russia Alexander Panteleev Head of the HIV/TB department City TB Hospital # 2, St-Petersburg, Russia

14

38

55

3022 20

28 2935

68

9085

86 83 83 83

72

82

0

10

2030

40

50

60

7080

90

100

1999 2000 2001 2002 2003 2004 2005 2006 2007

HIV TB

New cases of HIV and TB in Russia1999-2007, per 100.000 population

O. Frolova 2009 Russian Federal Centre of TB/HIV Surveillance

Page 7: HIV-infection in Russia Alexander Panteleev Head of the HIV/TB department City TB Hospital # 2, St-Petersburg, Russia

New cases of HIV/TB in Russia 1999-2008

O. Frolova 2009 Russian Federal Centre of TB/HIV Surveillance

271 310 576 833 9901407

3907

5985

7387

2926

0,7

4,2

2,7

2,1

1,0

0,60,40,20,2

5,2

0

1000

2000

3000

4000

5000

6000

7000

8000

1999 2000 2001 2002 2003 2004 2005 2006 2007 2008

0

1

2

3

4

5

6

cases per 100.000 population

N o

f new

HIV

/TB

case

s

Per 1

00.0

00 p

opul

ation

Page 8: HIV-infection in Russia Alexander Panteleev Head of the HIV/TB department City TB Hospital # 2, St-Petersburg, Russia

050

100150200250300350400450

2000 2001 2002 2003 2004 2005 2006 2007 2008

TB other causes

TB mortality among overall mortality of HIV-patients 2000-2008 St-Petersburg, Russia

N o

f HIV

pati

ents

die

d

St. Petersburg City AIDS Centre

Page 9: HIV-infection in Russia Alexander Panteleev Head of the HIV/TB department City TB Hospital # 2, St-Petersburg, Russia

Incidence of HIV and TB in general population and incidence of TB in HIV-population

2000-2008 St.-Petersburg, Russia

37.1

660.7

1277

209.3 304.9329.2

397.2

556.7628.1

0

50

100

150

200

250

2000 2001 2002 2003 2004 2005 2006 2007 2008

0

200

400

600

800

1000

1200

1400

TB HIV TB+HIV

A. Panteleev et al 2009

Per 1

00.0

00 g

ener

al p

opul

ation

Per 1

00.0

00 H

IV-in

fect

ed

Page 10: HIV-infection in Russia Alexander Panteleev Head of the HIV/TB department City TB Hospital # 2, St-Petersburg, Russia

Proportion of HIV cases among newly diagnosed TB cases

TB hospital #2 St-Petersburg, Russia

26.2

0.1 0.10.9

2.6 3.1

6.28.0

10.6

15.6

0

5

10

15

20

25

30

1999 2000 2001 2002 2003 2004 2005 2006 2007 2008

%

Page 11: HIV-infection in Russia Alexander Panteleev Head of the HIV/TB department City TB Hospital # 2, St-Petersburg, Russia

MDR XDR

10%56%

Drug resistance in HIV/TB patients TB hospital #2 St-Petersburg, Russia

N tested 604 N tested 284

Page 12: HIV-infection in Russia Alexander Panteleev Head of the HIV/TB department City TB Hospital # 2, St-Petersburg, Russia

HAART in patients with HIV/TBTB hospital #2 St-Petersburg, Russia

HAART + HAART -

10%

29%

22%

39%

4%

5%

13%

78%

Cure Chronical forms Without dynamics Death