holotranscobalamin laboratory : 216 date : dd-mmm … · date : dd-mmm-yyyy feedback page 1...

Date : DD-MMM-YYYY

Feedback

Holotranscobalamin

Distribution : 216

Laboratory :

Birmingham Quality is part of the University Hospitals Birmingham NHS Foundation Trust

and provides this UK NEQAS service from PO Box 3909, Birmingham B15 2UE, UK

To contact us, email [email protected] or phone us on +44 (0)121 414 7300

© The data in this UK NEQAS report are confidential.

For this Scheme, the Organiser is Dr. Malcolm Hamilton.

www.birminghamquality.org.uk Published at 14:36 on Friday 11 March 2016

Quality ManagerPathology LaboratoryBiochemistry DepartmentTownCountyPostcode

This Scheme is essentially web-based. We can alert you to information regarding the Scheme via email. The e-mail address (or addresses) we are currently using to contact your laboratory is shown below in red . If no e-mail address is displayed or the information shown is incorrect, please email us with an appropriate contact e-mail address as soon as possible, using the word 'feedback' in the title line.

Based on the date information you have provided, the transit time from specimen dispatch [ ] to receipt [ ] was day(s), and the subsequent time to analysis [ ] in your laboratory was day(s). (Missing values indicate dates not provided. "0 days" represents same day).

Any comments you made to us are shown below and have been acted upon where necessary

Any specific comments applicable only to laboratory are shown below

Any general comments applicable to all laboratories are shown below

*****Birmingham Quality Participant Survey*****

We are currently undertaking our annual participant survey and would very much welcome your feedback. Your comments are very important to us and will help us to improve the service we provide to you. The survey relates only to the Clinical Chemistry EQA services provided from the Birmingham Quality [UK NEQAS] centre.

A copy of the questionnaire is attached to the back of this report. It is very simple and asks only two questions:

1) What do we do well? and2) What could we do better?

We are very happy for you to submit your comments anonymously but please do provide your contact details on the form ONLY if you would like to receive a response.

Please e-mail the completed survey to [email protected] or FAX to +44 (0) 121 414 1179

Many thanks

The Birmingham Quality Team

Report authorised on Monday 15 June 2015 by

Deputy Director, Birmingham Quality Finlay MacKenzie

Birmingham Quality is a UKAS accredited proficiency testing provider No. 7860. Please see http://www.ukas.com for full details of the accreditation status of our services

Birmingham Quality is proud to offer EQA services that adhere to the Code of Practice and have the badge of quality of UK NEQAS

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Holotranscobalamin

Distribution : 216 Date : DD-MMM-YYYY

Performance Summary Icons (click graph for details)

Laboratory :







B s

core

C score

HoloTC

P-ABCPENR (DASH1)

0 5 10 15 20

-20

-15

-10

-5

0

5

10

15

20

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Date : DD-MMM-YYYY

Participation summary

Holotranscobalamin

Distribution : 216

Laboratory :







All our time periods are 'rolling' to give you current information. You may wish to keep you own log of Calendar Year or Financial Year time points if you require 'year-end' statements for your own internal use. Any analytes with out of consensus performance will be highlighted in red and can be clicked for further details.

You have no performance data for:

You have in consensus performance for:

You have out of consensus performance for:

HoloTC

Analytical Performance over the last 6 months (rolling time window of 6 distributions)

None

None

This scheme cycle is notionally every four weeks. Analytically, we assess you over a six month time window (6 Distributions). For return rates, late and amended results we assess you over a twelve month period (12 distributions).

Participation 11 distributions out of a possible 12

Satisfactory

0 distributions from the last 11Late Returns

Amendments 0 distributions accepted from the last 11

Satisfactory

Satisfactory

Distributions

Participation and Return Rates

Rating

You can judge, in association with your IQC and other QA measures, if your current performance is a blip or part of a trend.

You have no specimen data for:

In consensus for all specimens for: HoloTC

Out of consensus for at least one specimen for:

You are not registered for:

None

Analytical Performance for specimens from distribution 216 only

None

None

The new Participation Summary page is an exciting new feature which we hope you will like. It is currently in prototype mode but will ultimately expand into having the Interpretative analytes as well as the existing ‘numerical’ analytes listed and will contain turnaround graphs etc., too.

For the moment it would be helpful if you could check the accuracy of the data presented, particularly the return-rate elements.

Many thanks, Finlay

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Date : DD-MMM-YYYY

Distribution Summary

Holotranscobalamin

Distribution : 216

Laboratory :







%biasBResult A score C scorePool CB scoreTargetSpecimen ASpecimen

NN

74.5

-6.5

216A

53.4(pmol/L)HoloTC

-0.6

216B

53.1

218(L, I, N or H)

N

220216B

HoloTC Interpretation

13.0

219220

78.8 -5.5

N

35.0216A

N

+0.7219

78218

216C N

216C

32.7

If your laboratory is outside of the acceptable limits of performance for any its rolling time-window scores (A, B or C scores), this will be indicated by a red traffic light symbol. It is the responsibility of the laboratory to undertake an internal investigation to establish the underlying cause and put in place corrective and preventive action. Please do not wait to receive a formal notification of performance from the Scheme Organiser or the National Quality Assurance Advisory Panel (NQAAP) before logging the non-conformity and, where necessary, acting upon the data contained in your report. A green traffic light merely reflects that your laboratory is performing as well as the state-of-the-art allows; it does not necessarily mean that your assay / laboratory performance is good enough clinically.

The “A scores” in this report are currently based on a ‘flat 10%’ degree of difficulty. Once we have accumulated more data points we will be able to calculate concentration-dependent degree of difficulty factors and put them in the same ‘currency’ as the A scores in other Schemes. But, for the moment, the “A scores” for HoloTC are only “proto A scores. Please see the online 'Explanation of the ABC of EQA' which may be found under the 'Centre' button on the UK NEQAS Results & Reports page. You will need your user-name and password to access this information.

All samples issued have been tested negative by standard methods for HIV, TPHA, Hepatitis B and C.

Gentamicin, penicillin and fluconazole have been added to all specimens.

Specimens for Distribution 217 will be dispatched on Monday 15 June 2015, results are due back in Birmingham by, notionally, 23:59 on Sunday 5 July 2015.

If we have entered your result as OMIT , it is because the numerical value we obtained from you was implausible for that analyte.

If we have entered your result as XPL , it is because you did not report a numerical value for that analyte, but you did provide an explanation as to why a result was not reported.

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Date : DD-MMM-YYYY

Method Summary

Holotranscobalamin

Distribution : 216

Laboratory :







arrow median

Units Method

A score

Your Submethod

A scoremedian

A scoreYour Method All labwith trend

60pmol/L

HoloTC Interpretation

Abbott Architect [AB13]

L, I, N or H

HoloTC 78 55

Our method update service is web-based and is accessed online via the 'Methods' button on the 'Results and Reports page'. You can select from a dropdown of methods or select the default option from the major manufacturer’s products*.

*If you are not using the system according to the manufacturer's instructions, please select the in-house category within your system's method principle.

A s

core

Graphic Equalizer Plot of A scoresAll laboratories

P-BWATSCR2HO

LO

0

50

100

150

200

250

300

A s

core

Method Graphic Equalizer Plot of A scoresfor your methods

P-BWATSCM2HO

LO

0

50

100

150

200

250

300

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Date : DD-MMM-YYYY

Cumulative Summary

Holotranscobalamin

Distribution : 216

Laboratory :







B s

core

C score

HoloTC B and C scoresby method

ABCPENLM (PBOX_MINOR)

0 5 10 15 20-20

-15

-10

-5

0

5

10

15

20Abbott Architect [AB13]

In house ELISA [OO9]

Not stated, please specify

Siemens ELISA BEPIII [BE3]

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Date : DD-MMM-YYYY

Analyte : HoloTC (pmol/L)

Holotranscobalamin

Distribution : 216

Laboratory :







Human serum

220

Pool description / Treatments / Additions

216B Human serumHuman serum

Pool

219

Spec.

216A

216C

218 13.0

The B limit is +/-

Your B score is

The A limit is15.0

78

15.0

Your A score is+0.7

The C limit is

200

Your C score is

Based on the information you have provided, your reagent lot number is [] and your calibrator lot number is []. (Missing values indicate data not provided).

All methods Abbott Architect [AB13]

Specimen : 216A

24 29 34 39 44HoloTC (pmol/L)

0

2

4

6

8

10

no. o

f lab

orat

orie

s


34.6

35.0

2

Mean


n

32.6

1

In house ELISA [OO9]35.0

41

SD

7.8

35

3

2.6 7.4

2.7

CV(%)

36.1Not stated, please specify

All methods [ALTM](ALTM)

35.0

transformed bias

32.7Your result

-65

Method mean

-6.5Your specimen:

35.0

[MLTM]

Standard Uncertainty

%bias

65

0.58

Accuracy Index

Target value

Specimen : 216B

42 48 54 60 66HoloTC (pmol/L)

0

2

4

6

8

10

no. o

f lab

orat

orie

s


53.5

53.4

2

Mean


n

44.2

1


41

SD

7.8

35

3

3.9 7.2

4.1

CV(%)



53.8

transformed bias

53.1Your result

-6

Method mean

-0.6Your specimen:

[MLTM]

53.4


6

%bias

Accuracy Index

0.88

Target value

Specimen : 216C

60 69 78 87 96HoloTC (pmol/L)

0

5

10

15

20

no. o

f lab

orat

orie

s


78.7

78.8

2

Mean


n

68.4

1


41

SD

7.3

35

3

5.4 6.8

5.8

CV(%)



79.3

transformed bias

74.5Your result

-55

Method mean

-5.5Your specimen:

[MLTM]

78.8


55

%bias

Accuracy Index

1.22

Target value

B s

core

HoloTC Median and IQRs of B scores

P-BWABCBR

AB

13

-20

-15

-10

-5

0

5

10

15

20

All

Met

hod

C s

core

HoloTC Median and IQRs of C scores

P-BWABCCR

AB

13

0

5

10

15

20

All

Met

hod

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Pool

(exclusion)

[Type]

Distribution 211

28-Nov-2014

result target %bias

Distribution 212

01-Feb-2015

result target %bias

Distribution 213

01-Mar-2015

result target %bias

Distribution 214

29-Mar-2015

result target %bias

Distribution 215

03-May-2015

result target %bias

Distribution 216

07-Jun-2015

result target %bias

Distribution

result target %bias

17.5 17.08 +2.5204 26.4 21.69 +21.7 21.60207

32.3 32.7 -1.4217 32.7 35.0 -6.5218

34.6 36.6 -5.5214 42.6 37.8 +12.6211

38.3 41.6 -8.0209 48.3 52.9 -8.7203

53.1 53.4 -0.6219 61.7 58.0 +6.4 60.6210

72.5 76.8 -5.6216 74.5 78.8 -5.5220

95.6 81.3 +17.7212 102.0213

102.8 110.4 -6.9206 145.4 121.2 +19.9208

MethodmeanA scoreB scoreC score

AB13+18.1

74+1.511.1

AB13+8.9

78+3.511.4

AB13-7.9

81+1.612.7

AB13

87+3.513.8

AB13-4.2

85+3.813.3

AB13-4.2

78+0.713.0

Date : DD-MMM-YYYY

Analyte : HoloTC (pmol/L)

Holotranscobalamin

Distribution : 216

Laboratory :







Based on the information you have provided, your reagent lot number is [] and your calibrator lot number is []. (Missing values indicate data not provided).

A s

core

HoloTC Median and IQRs of A scores

P-BWABCAT

AB

13

0

50

100

150

200

250

300

All

Met

hod

B s

core

HoloTC Median and IQRs of B scores

P-BWABCBR

AB

13

-20

-15

-10

-5

0

5

10

15

20

All

Met

hod

B s

core

C score

HoloTC B score is +0.7 and C score is 13.0 Abbott Architect [AB13]

P-ABCPENR

0 5 10 15 20-20

-15

-10

-5

0

5

10

15

20Your labYour methodOverall (n=37)Your method (n=32)

C s

core

HoloTC Median and IQRs of C scores

P-BWABCCR

AB

13

0

5

10

15

20

All

Met

hod

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Date : DD-MMM-YYYY

HoloTC pmol/L

Holotranscobalamin

Distribution : 216

Laboratory :







Spe

cim

en A

ccur

acy

Inde

x

Distribution

Specimen Accuracy Indexfor each specimen in time-window

P-ABCATS (ABC1)

211 212 213 214 215 2160

50

100

150

200

250

300

A s

core

Distribution

A score by distributionYour current A score is 78

P-ABCAT (ABC1)

206 208 210 212 214 2160

50

100

150

200

250

300

All

Met

hod

Spe

cim

en %

bias

Distribution

Specimen %biasfor each specimen in time-window

P-ABCBRS (ABC1)

211 212 213 214 215 216-20

-15

-10

-5

0

5

10

15

20

B s

core

Distribution

B score by distributionYour current B score is +0.7

P-ABCBR (ABC1)

206 208 210 212 214 216-20

-15

-10

-5

0

5

10

15

20

All

Met

hod

Diff

eren

ce (

pmol

/L)

Concentration (pmol/L)

Difference (result - target)for each specimen in time-window

P-BA1FS1A (ABC1)

0 20 40 60 80 100 120-30

-20

-10

0

10

20

30

C s

core

Distribution

C score by distributionYour current C score is 13.0

P-ABCCR (ABC1)

206 208 210 212 214 2160

5

10

15

20

All

Met

hod

Spe

cim

en %

bias


Specimen %biasfor each specimen in time-window

P-BA1FS1P (ABC1)

0 20 40 60 80 100 120-20

-15

-10

-5

0

5

10

15

20

B s

core

C score

HoloTC B score is +0.7 and C score is 13.0 Abbott Architect [AB13]

P-ABCPENR (ABC1)

0 5 10 15 20-20

-15

-10

-5

0

5

10

15

20Your labYour methodOverall (n=37)Your method (n=32)

Spe

cim

en A

ccur

acy

Inde

x


Specimen Accuracy Indexfor each specimen in time-window

P-YSTMOD (ABC1)

0 20 40 60 80 100 1200

50

100

150

200

250

300 ALTMMLTM

CV

%


HoloTC Between-laboratory agreementAbbott Architect [AB13]

P-PROFILE (ABC1)

0 20 40 60 80 100 1200

10

20

30

40

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Birmingham Quality Participants’ Questionnaire

This is a very brief questionnaire specifically about the EQA services provided by the Birmingham Quality

[UK NEQAS] Centre. Your feedback is very important to us and will help us to improve our service to you

so please be as specific as possible when answering the questions below. A brief ‘memory jogger’ has

been provided overleaf but please do comment on any aspect of our service.

Please provide your contact details overleaf ONLY if you would like us to respond to your comments.

We are always happy to receive anonymous feedback.

What do we do well?

What could we do better?

Please use this space to suggest improvements or make recommendations

Please complete and return to Birmingham Quality by e-mail: [email protected] or

FAX +44 (0) 121 414 1179

Date : DD-MMM-YYYY

Holotranscobalamin

Distribution : 216

Laboratory :







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Memory Jogger

Our interaction with participants

• Joining / signing-up to EQA programmes

• E-mail notifications of specimen dispatch / reportpublication

• Information on the Birmingham Quality website(www.BirminghamQuality.org.uk)

• Entering your results online

• Viewing your reports online

• Updating your information (methods, contact e-mailaddresses etc)

• Responses to telephone enquiries

• Should we use other forms of social media tocommunicate with participants? E.g. Twitter,Facebook, Instagram etc

• Meetings / training days

• Invoicing

• Payment

EQA programmes

• Are there any additional programmes / analytes thatyou would like us to provide EQA services for?

• What could we do to improve / enhance any of ourexisting EQA programmes?

• Interpretative EQA programmes e.g. UK NEQAS forInterpretative Comments

• Fees

EQA specimens

• Number of specimens per distribution

• Frequency of distributions

• Type of material provided

• Volume of material provided (scheme-specific)

• Sample tubes

• Packaging

• Mechanism of delivery (postal service etc)

• Information on results documents

• Booking-in process

EQA reports

• Information contained in the report e.g. tables,statistics (mean, SD, CV%, median, IQR) etc

• Information about your performance e.g. ParticipationSummary page, numerical scores (ABC of EQA), trafficlights, colour-coded symbols, etc

• Graphs (e.g. histograms, pie charts, penalty box plotsetc)

• Network reports

Problem solving

• Notification of (poor) performance

• Availability / usefulness of help and advice fromBirmingham Quality

Your contact details*

Your UK NEQAS laboratory number (if known):

Title: Job title:

First name:

Surname:

Organisation:

Address 1:

Address 2:

Postcode: Country:

E-mail address:

Mobile tel no: Work tel no:

*Your details will only be used for the purposes of responding to your comments and will not be shared with any third parties.

Date : DD-MMM-YYYY

Holotranscobalamin

Distribution : 216

Laboratory :







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