Upload File

homeopathy and the microbiome - ihs new yorkhomeopathy and the microbiome a key to lyme and other...

  • Home
  • Documents
  • Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy
163
Homeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy Clinical Assistant Professor, Family and Community Medicine New York Medical College

Upload: others

Post on 13-Mar-2020

7 views

Category:

Documents


0 download

Report

TRANSCRIPT

Page 1: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Homeopathy and the

Microbiome A key to Lyme and other chronic diseases

Ronald D Whitmont MD President

The American Institute of Homeopathy

Clinical Assistant Professor

Family and Community Medicine

New York Medical College

Discussion Goals

bull The Human Microbiome

bull An Epidemic of Chronic Disease

bull Chronic Lyme Disease

bull Homeopathy

The Human Microbiome

Microbiome

bull An ecology of symbiosis

bull Synonymous with health

bull Damage leads to Dysbiosis

bull Dysbiosis triggers inflammation

The Human Microbiome Project

bull Launched in 2008 by the NIH

bull Multicenter Research Project

bull Genetic Sequencing Technology

httpwwwhmpdaccorg

The Human Microbiome Project

ndash Nasal passages

ndash Oral cavity

ndash Skin

ndash Gastrointestinal tract

ndash Urogenital tract

httpwwwhmpdaccorg

Ecological Complexity

Metagenomic studies reveal that the

human microbiome is comprised of

an exceedingly complex group of

different ecological niches existing

throughout the body

Nature 2007 Oct 18 449(7164) 804ndash810 The human

microbiome project exploring the microbial part of ourselves in

a changing world Turnbaugh PJ Ley RE Hamady M et al

DOI 101038nature06244

The Supra-Organism

ndash A symbiotic group of human and

microbial cells

ndash Working collectively for the

benefit of the whole

Medical Hypotheses 74(2)2010214215 The human

superorganism ndash Of microbes and men Sleator RD (Ed)

DOI 101016jmehy200908047

The Supra-Organism

A collection of ecosystems

dependent on

ndash Diversity

ndash Balanced ecology

ndash Symbiosis

Genome Biology 201314R1 Biogeography of the

ecosystems of the healthy human body Zhou Y Gao

H Mihindukulasuriya KA et al

DOI 101186gb-2013-14-1-r1

The Human Microbiome

The microbial genome complements

the human genome

Nature 2007 Oct 18 449(7164) 804ndash810 The human

microbiome project exploring the microbial part of ourselves in

a changing world Turnbaugh PJ Ley RE Hamady M et al

DOI 101038nature06244

The Human Microbiome

Traits integral to

bull Nutrition

bull Development

bull Immunity

bull Health

PLOSOne June 13 2012 Analyses of the Microbial Diversity

across the Human Microbiome Li K Bihan M Yooseph S et

al

DOI 101371journalpone0032118

The Human Microbiome

Regulates development and

function of the immune system

Cell Host amp Microbe Control of Brain Development Function

and Behavior by the Microbiome Sampson TR Mazmanian

SK

DOI 101016jchom201504011

Colonization

Begins in the placenta

Science Translational Med 21 May 20146(237) 237ra65 The Placenta Harbors a Unique Microbiome Aagaard K Ma J Antony KM et al

DOI 101126scitranslmed3008599

Most Critical Period

Before birth until two years of life

NutrReviews65(6)259-299 Perinatal and Neonatal Manipulation of the Intestinal Microbiome a Note of Caution Neu J

DOI 101111j1753-48872007tb00305x

Medications Damage the

Microbiome

bull Antibiotics antifungals antivirals

bull PPIrsquos

bull Glucocorticosteroids Antihistamines

bull SSRIrsquos HRT Chemotherapy

bull Immunosuppressants Vaccines

Antibiotics

bull Disrupt ecology of the microbiome

bull Alter microbiota via

ndash Overgrowth of resistant organisms

ndash Inhibition and destruction of sensitive

organisms

Science 2012 336(6086)1255-1262 The Application of Ecological Theory

Toward an Understanding of the Human Microbiome Costello EK

Stagaman K Dethlefsen L

DOI 101126science1224203

Antibiotics

Promote fungal (viral) overgrowth

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Antibiotics and Asthma

Maternal antibiotic use in pregnancy

associated with 89 increased risk

of childhood asthma (plt00001)

Medscape ObGyn Womenrsquos Health November 27 2016

Coverage from the American College of Allergy Asthma amp

Immunology (ACAAI) 2016 Annual Scientific Meeting

httpwwwmedscapecomviewarticle872028nlid=110951_25

81ampsrc=WNL_mdplsnews_161202_mscpedit_obgyampuac=2427

86PXampspon=16ampimpID=1245995ampfaf=1

Asthma and Antibiotics in the First

Year of Life

bull 1-2 Courses 20 increased risk

bull 3-4 Courses 30 increased risk

bull gt 4 Courses 50 increased risk

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Asthma and Antibiotics in the First

Year of Life

bull Risk of asthma was highest in children receiving more than four courses of antibiotics

bull Broad-spectrum cephalosporin use was more common in these subpopulations of children

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Antibiotics and Asthma

bull Adjusted odds ratio of 405 if ABX used in 1st year

of life

bull Adjusted odds ratio of 164 if ABX used after 1st

year of life

Clinical amp Experimental Allergy29(6)1999766ndash771 Antibiotic use in early childhood

and the development of asthma Wickens Pearce Crane et al

DOI 101046j1365-2222199900536x

Over the past four decades there

has been a significant increase in

allergy and asthma in westernized

countries which correlates with

alterations in fecal microbiota

(microflora) and widespread use of

antibiotics

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Pediatrics

Since 1980 the prevalence of many

chronic diseases including Asthma

has nearly tripled

MMWR Surveillance for Asthma -- United States 1960-1995

Mannino DM Homa DM Pertowski CA

httpswwwcdcgovmmwrpreviewmmwrhtml00052262htm

Asthma

bull The leading cause of chronic illness in US children

bull One of the fastest growing chronic conditions in developed nations

Population Reference Bureau Childhood Asthma A Growing American Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmericanEpidemicaspx

Asthma

Between 1980-1994

bull The total number of affected children

increased by 75

bull In children younger than 4 years it increased

by 160

Population Reference Bureau Childhood Asthma A Growing American

Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmerica

nEpidemicaspx

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 2: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Discussion Goals

bull The Human Microbiome

bull An Epidemic of Chronic Disease

bull Chronic Lyme Disease

bull Homeopathy

The Human Microbiome

Microbiome

bull An ecology of symbiosis

bull Synonymous with health

bull Damage leads to Dysbiosis

bull Dysbiosis triggers inflammation

The Human Microbiome Project

bull Launched in 2008 by the NIH

bull Multicenter Research Project

bull Genetic Sequencing Technology

httpwwwhmpdaccorg

The Human Microbiome Project

ndash Nasal passages

ndash Oral cavity

ndash Skin

ndash Gastrointestinal tract

ndash Urogenital tract

httpwwwhmpdaccorg

Ecological Complexity

Metagenomic studies reveal that the

human microbiome is comprised of

an exceedingly complex group of

different ecological niches existing

throughout the body

Nature 2007 Oct 18 449(7164) 804ndash810 The human

microbiome project exploring the microbial part of ourselves in

a changing world Turnbaugh PJ Ley RE Hamady M et al

DOI 101038nature06244

The Supra-Organism

ndash A symbiotic group of human and

microbial cells

ndash Working collectively for the

benefit of the whole

Medical Hypotheses 74(2)2010214215 The human

superorganism ndash Of microbes and men Sleator RD (Ed)

DOI 101016jmehy200908047

The Supra-Organism

A collection of ecosystems

dependent on

ndash Diversity

ndash Balanced ecology

ndash Symbiosis

Genome Biology 201314R1 Biogeography of the

ecosystems of the healthy human body Zhou Y Gao

H Mihindukulasuriya KA et al

DOI 101186gb-2013-14-1-r1

The Human Microbiome

The microbial genome complements

the human genome

Nature 2007 Oct 18 449(7164) 804ndash810 The human

microbiome project exploring the microbial part of ourselves in

a changing world Turnbaugh PJ Ley RE Hamady M et al

DOI 101038nature06244

The Human Microbiome

Traits integral to

bull Nutrition

bull Development

bull Immunity

bull Health

PLOSOne June 13 2012 Analyses of the Microbial Diversity

across the Human Microbiome Li K Bihan M Yooseph S et

al

DOI 101371journalpone0032118

The Human Microbiome

Regulates development and

function of the immune system

Cell Host amp Microbe Control of Brain Development Function

and Behavior by the Microbiome Sampson TR Mazmanian

SK

DOI 101016jchom201504011

Colonization

Begins in the placenta

Science Translational Med 21 May 20146(237) 237ra65 The Placenta Harbors a Unique Microbiome Aagaard K Ma J Antony KM et al

DOI 101126scitranslmed3008599

Most Critical Period

Before birth until two years of life

NutrReviews65(6)259-299 Perinatal and Neonatal Manipulation of the Intestinal Microbiome a Note of Caution Neu J

DOI 101111j1753-48872007tb00305x

Medications Damage the

Microbiome

bull Antibiotics antifungals antivirals

bull PPIrsquos

bull Glucocorticosteroids Antihistamines

bull SSRIrsquos HRT Chemotherapy

bull Immunosuppressants Vaccines

Antibiotics

bull Disrupt ecology of the microbiome

bull Alter microbiota via

ndash Overgrowth of resistant organisms

ndash Inhibition and destruction of sensitive

organisms

Science 2012 336(6086)1255-1262 The Application of Ecological Theory

Toward an Understanding of the Human Microbiome Costello EK

Stagaman K Dethlefsen L

DOI 101126science1224203

Antibiotics

Promote fungal (viral) overgrowth

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Antibiotics and Asthma

Maternal antibiotic use in pregnancy

associated with 89 increased risk

of childhood asthma (plt00001)

Medscape ObGyn Womenrsquos Health November 27 2016

Coverage from the American College of Allergy Asthma amp

Immunology (ACAAI) 2016 Annual Scientific Meeting

httpwwwmedscapecomviewarticle872028nlid=110951_25

81ampsrc=WNL_mdplsnews_161202_mscpedit_obgyampuac=2427

86PXampspon=16ampimpID=1245995ampfaf=1

Asthma and Antibiotics in the First

Year of Life

bull 1-2 Courses 20 increased risk

bull 3-4 Courses 30 increased risk

bull gt 4 Courses 50 increased risk

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Asthma and Antibiotics in the First

Year of Life

bull Risk of asthma was highest in children receiving more than four courses of antibiotics

bull Broad-spectrum cephalosporin use was more common in these subpopulations of children

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Antibiotics and Asthma

bull Adjusted odds ratio of 405 if ABX used in 1st year

of life

bull Adjusted odds ratio of 164 if ABX used after 1st

year of life

Clinical amp Experimental Allergy29(6)1999766ndash771 Antibiotic use in early childhood

and the development of asthma Wickens Pearce Crane et al

DOI 101046j1365-2222199900536x

Over the past four decades there

has been a significant increase in

allergy and asthma in westernized

countries which correlates with

alterations in fecal microbiota

(microflora) and widespread use of

antibiotics

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Pediatrics

Since 1980 the prevalence of many

chronic diseases including Asthma

has nearly tripled

MMWR Surveillance for Asthma -- United States 1960-1995

Mannino DM Homa DM Pertowski CA

httpswwwcdcgovmmwrpreviewmmwrhtml00052262htm

Asthma

bull The leading cause of chronic illness in US children

bull One of the fastest growing chronic conditions in developed nations

Population Reference Bureau Childhood Asthma A Growing American Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmericanEpidemicaspx

Asthma

Between 1980-1994

bull The total number of affected children

increased by 75

bull In children younger than 4 years it increased

by 160

Population Reference Bureau Childhood Asthma A Growing American

Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmerica

nEpidemicaspx

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 3: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

The Human Microbiome

Microbiome

bull An ecology of symbiosis

bull Synonymous with health

bull Damage leads to Dysbiosis

bull Dysbiosis triggers inflammation

The Human Microbiome Project

bull Launched in 2008 by the NIH

bull Multicenter Research Project

bull Genetic Sequencing Technology

httpwwwhmpdaccorg

The Human Microbiome Project

ndash Nasal passages

ndash Oral cavity

ndash Skin

ndash Gastrointestinal tract

ndash Urogenital tract

httpwwwhmpdaccorg

Ecological Complexity

Metagenomic studies reveal that the

human microbiome is comprised of

an exceedingly complex group of

different ecological niches existing

throughout the body

Nature 2007 Oct 18 449(7164) 804ndash810 The human

microbiome project exploring the microbial part of ourselves in

a changing world Turnbaugh PJ Ley RE Hamady M et al

DOI 101038nature06244

The Supra-Organism

ndash A symbiotic group of human and

microbial cells

ndash Working collectively for the

benefit of the whole

Medical Hypotheses 74(2)2010214215 The human

superorganism ndash Of microbes and men Sleator RD (Ed)

DOI 101016jmehy200908047

The Supra-Organism

A collection of ecosystems

dependent on

ndash Diversity

ndash Balanced ecology

ndash Symbiosis

Genome Biology 201314R1 Biogeography of the

ecosystems of the healthy human body Zhou Y Gao

H Mihindukulasuriya KA et al

DOI 101186gb-2013-14-1-r1

The Human Microbiome

The microbial genome complements

the human genome

Nature 2007 Oct 18 449(7164) 804ndash810 The human

microbiome project exploring the microbial part of ourselves in

a changing world Turnbaugh PJ Ley RE Hamady M et al

DOI 101038nature06244

The Human Microbiome

Traits integral to

bull Nutrition

bull Development

bull Immunity

bull Health

PLOSOne June 13 2012 Analyses of the Microbial Diversity

across the Human Microbiome Li K Bihan M Yooseph S et

al

DOI 101371journalpone0032118

The Human Microbiome

Regulates development and

function of the immune system

Cell Host amp Microbe Control of Brain Development Function

and Behavior by the Microbiome Sampson TR Mazmanian

SK

DOI 101016jchom201504011

Colonization

Begins in the placenta

Science Translational Med 21 May 20146(237) 237ra65 The Placenta Harbors a Unique Microbiome Aagaard K Ma J Antony KM et al

DOI 101126scitranslmed3008599

Most Critical Period

Before birth until two years of life

NutrReviews65(6)259-299 Perinatal and Neonatal Manipulation of the Intestinal Microbiome a Note of Caution Neu J

DOI 101111j1753-48872007tb00305x

Medications Damage the

Microbiome

bull Antibiotics antifungals antivirals

bull PPIrsquos

bull Glucocorticosteroids Antihistamines

bull SSRIrsquos HRT Chemotherapy

bull Immunosuppressants Vaccines

Antibiotics

bull Disrupt ecology of the microbiome

bull Alter microbiota via

ndash Overgrowth of resistant organisms

ndash Inhibition and destruction of sensitive

organisms

Science 2012 336(6086)1255-1262 The Application of Ecological Theory

Toward an Understanding of the Human Microbiome Costello EK

Stagaman K Dethlefsen L

DOI 101126science1224203

Antibiotics

Promote fungal (viral) overgrowth

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Antibiotics and Asthma

Maternal antibiotic use in pregnancy

associated with 89 increased risk

of childhood asthma (plt00001)

Medscape ObGyn Womenrsquos Health November 27 2016

Coverage from the American College of Allergy Asthma amp

Immunology (ACAAI) 2016 Annual Scientific Meeting

httpwwwmedscapecomviewarticle872028nlid=110951_25

81ampsrc=WNL_mdplsnews_161202_mscpedit_obgyampuac=2427

86PXampspon=16ampimpID=1245995ampfaf=1

Asthma and Antibiotics in the First

Year of Life

bull 1-2 Courses 20 increased risk

bull 3-4 Courses 30 increased risk

bull gt 4 Courses 50 increased risk

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Asthma and Antibiotics in the First

Year of Life

bull Risk of asthma was highest in children receiving more than four courses of antibiotics

bull Broad-spectrum cephalosporin use was more common in these subpopulations of children

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Antibiotics and Asthma

bull Adjusted odds ratio of 405 if ABX used in 1st year

of life

bull Adjusted odds ratio of 164 if ABX used after 1st

year of life

Clinical amp Experimental Allergy29(6)1999766ndash771 Antibiotic use in early childhood

and the development of asthma Wickens Pearce Crane et al

DOI 101046j1365-2222199900536x

Over the past four decades there

has been a significant increase in

allergy and asthma in westernized

countries which correlates with

alterations in fecal microbiota

(microflora) and widespread use of

antibiotics

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Pediatrics

Since 1980 the prevalence of many

chronic diseases including Asthma

has nearly tripled

MMWR Surveillance for Asthma -- United States 1960-1995

Mannino DM Homa DM Pertowski CA

httpswwwcdcgovmmwrpreviewmmwrhtml00052262htm

Asthma

bull The leading cause of chronic illness in US children

bull One of the fastest growing chronic conditions in developed nations

Population Reference Bureau Childhood Asthma A Growing American Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmericanEpidemicaspx

Asthma

Between 1980-1994

bull The total number of affected children

increased by 75

bull In children younger than 4 years it increased

by 160

Population Reference Bureau Childhood Asthma A Growing American

Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmerica

nEpidemicaspx

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 4: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Microbiome

bull An ecology of symbiosis

bull Synonymous with health

bull Damage leads to Dysbiosis

bull Dysbiosis triggers inflammation

The Human Microbiome Project

bull Launched in 2008 by the NIH

bull Multicenter Research Project

bull Genetic Sequencing Technology

httpwwwhmpdaccorg

The Human Microbiome Project

ndash Nasal passages

ndash Oral cavity

ndash Skin

ndash Gastrointestinal tract

ndash Urogenital tract

httpwwwhmpdaccorg

Ecological Complexity

Metagenomic studies reveal that the

human microbiome is comprised of

an exceedingly complex group of

different ecological niches existing

throughout the body

Nature 2007 Oct 18 449(7164) 804ndash810 The human

microbiome project exploring the microbial part of ourselves in

a changing world Turnbaugh PJ Ley RE Hamady M et al

DOI 101038nature06244

The Supra-Organism

ndash A symbiotic group of human and

microbial cells

ndash Working collectively for the

benefit of the whole

Medical Hypotheses 74(2)2010214215 The human

superorganism ndash Of microbes and men Sleator RD (Ed)

DOI 101016jmehy200908047

The Supra-Organism

A collection of ecosystems

dependent on

ndash Diversity

ndash Balanced ecology

ndash Symbiosis

Genome Biology 201314R1 Biogeography of the

ecosystems of the healthy human body Zhou Y Gao

H Mihindukulasuriya KA et al

DOI 101186gb-2013-14-1-r1

The Human Microbiome

The microbial genome complements

the human genome

Nature 2007 Oct 18 449(7164) 804ndash810 The human

microbiome project exploring the microbial part of ourselves in

a changing world Turnbaugh PJ Ley RE Hamady M et al

DOI 101038nature06244

The Human Microbiome

Traits integral to

bull Nutrition

bull Development

bull Immunity

bull Health

PLOSOne June 13 2012 Analyses of the Microbial Diversity

across the Human Microbiome Li K Bihan M Yooseph S et

al

DOI 101371journalpone0032118

The Human Microbiome

Regulates development and

function of the immune system

Cell Host amp Microbe Control of Brain Development Function

and Behavior by the Microbiome Sampson TR Mazmanian

SK

DOI 101016jchom201504011

Colonization

Begins in the placenta

Science Translational Med 21 May 20146(237) 237ra65 The Placenta Harbors a Unique Microbiome Aagaard K Ma J Antony KM et al

DOI 101126scitranslmed3008599

Most Critical Period

Before birth until two years of life

NutrReviews65(6)259-299 Perinatal and Neonatal Manipulation of the Intestinal Microbiome a Note of Caution Neu J

DOI 101111j1753-48872007tb00305x

Medications Damage the

Microbiome

bull Antibiotics antifungals antivirals

bull PPIrsquos

bull Glucocorticosteroids Antihistamines

bull SSRIrsquos HRT Chemotherapy

bull Immunosuppressants Vaccines

Antibiotics

bull Disrupt ecology of the microbiome

bull Alter microbiota via

ndash Overgrowth of resistant organisms

ndash Inhibition and destruction of sensitive

organisms

Science 2012 336(6086)1255-1262 The Application of Ecological Theory

Toward an Understanding of the Human Microbiome Costello EK

Stagaman K Dethlefsen L

DOI 101126science1224203

Antibiotics

Promote fungal (viral) overgrowth

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Antibiotics and Asthma

Maternal antibiotic use in pregnancy

associated with 89 increased risk

of childhood asthma (plt00001)

Medscape ObGyn Womenrsquos Health November 27 2016

Coverage from the American College of Allergy Asthma amp

Immunology (ACAAI) 2016 Annual Scientific Meeting

httpwwwmedscapecomviewarticle872028nlid=110951_25

81ampsrc=WNL_mdplsnews_161202_mscpedit_obgyampuac=2427

86PXampspon=16ampimpID=1245995ampfaf=1

Asthma and Antibiotics in the First

Year of Life

bull 1-2 Courses 20 increased risk

bull 3-4 Courses 30 increased risk

bull gt 4 Courses 50 increased risk

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Asthma and Antibiotics in the First

Year of Life

bull Risk of asthma was highest in children receiving more than four courses of antibiotics

bull Broad-spectrum cephalosporin use was more common in these subpopulations of children

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Antibiotics and Asthma

bull Adjusted odds ratio of 405 if ABX used in 1st year

of life

bull Adjusted odds ratio of 164 if ABX used after 1st

year of life

Clinical amp Experimental Allergy29(6)1999766ndash771 Antibiotic use in early childhood

and the development of asthma Wickens Pearce Crane et al

DOI 101046j1365-2222199900536x

Over the past four decades there

has been a significant increase in

allergy and asthma in westernized

countries which correlates with

alterations in fecal microbiota

(microflora) and widespread use of

antibiotics

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Pediatrics

Since 1980 the prevalence of many

chronic diseases including Asthma

has nearly tripled

MMWR Surveillance for Asthma -- United States 1960-1995

Mannino DM Homa DM Pertowski CA

httpswwwcdcgovmmwrpreviewmmwrhtml00052262htm

Asthma

bull The leading cause of chronic illness in US children

bull One of the fastest growing chronic conditions in developed nations

Population Reference Bureau Childhood Asthma A Growing American Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmericanEpidemicaspx

Asthma

Between 1980-1994

bull The total number of affected children

increased by 75

bull In children younger than 4 years it increased

by 160

Population Reference Bureau Childhood Asthma A Growing American

Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmerica

nEpidemicaspx

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 5: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

The Human Microbiome Project

bull Launched in 2008 by the NIH

bull Multicenter Research Project

bull Genetic Sequencing Technology

httpwwwhmpdaccorg

The Human Microbiome Project

ndash Nasal passages

ndash Oral cavity

ndash Skin

ndash Gastrointestinal tract

ndash Urogenital tract

httpwwwhmpdaccorg

Ecological Complexity

Metagenomic studies reveal that the

human microbiome is comprised of

an exceedingly complex group of

different ecological niches existing

throughout the body

Nature 2007 Oct 18 449(7164) 804ndash810 The human

microbiome project exploring the microbial part of ourselves in

a changing world Turnbaugh PJ Ley RE Hamady M et al

DOI 101038nature06244

The Supra-Organism

ndash A symbiotic group of human and

microbial cells

ndash Working collectively for the

benefit of the whole

Medical Hypotheses 74(2)2010214215 The human

superorganism ndash Of microbes and men Sleator RD (Ed)

DOI 101016jmehy200908047

The Supra-Organism

A collection of ecosystems

dependent on

ndash Diversity

ndash Balanced ecology

ndash Symbiosis

Genome Biology 201314R1 Biogeography of the

ecosystems of the healthy human body Zhou Y Gao

H Mihindukulasuriya KA et al

DOI 101186gb-2013-14-1-r1

The Human Microbiome

The microbial genome complements

the human genome

Nature 2007 Oct 18 449(7164) 804ndash810 The human

microbiome project exploring the microbial part of ourselves in

a changing world Turnbaugh PJ Ley RE Hamady M et al

DOI 101038nature06244

The Human Microbiome

Traits integral to

bull Nutrition

bull Development

bull Immunity

bull Health

PLOSOne June 13 2012 Analyses of the Microbial Diversity

across the Human Microbiome Li K Bihan M Yooseph S et

al

DOI 101371journalpone0032118

The Human Microbiome

Regulates development and

function of the immune system

Cell Host amp Microbe Control of Brain Development Function

and Behavior by the Microbiome Sampson TR Mazmanian

SK

DOI 101016jchom201504011

Colonization

Begins in the placenta

Science Translational Med 21 May 20146(237) 237ra65 The Placenta Harbors a Unique Microbiome Aagaard K Ma J Antony KM et al

DOI 101126scitranslmed3008599

Most Critical Period

Before birth until two years of life

NutrReviews65(6)259-299 Perinatal and Neonatal Manipulation of the Intestinal Microbiome a Note of Caution Neu J

DOI 101111j1753-48872007tb00305x

Medications Damage the

Microbiome

bull Antibiotics antifungals antivirals

bull PPIrsquos

bull Glucocorticosteroids Antihistamines

bull SSRIrsquos HRT Chemotherapy

bull Immunosuppressants Vaccines

Antibiotics

bull Disrupt ecology of the microbiome

bull Alter microbiota via

ndash Overgrowth of resistant organisms

ndash Inhibition and destruction of sensitive

organisms

Science 2012 336(6086)1255-1262 The Application of Ecological Theory

Toward an Understanding of the Human Microbiome Costello EK

Stagaman K Dethlefsen L

DOI 101126science1224203

Antibiotics

Promote fungal (viral) overgrowth

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Antibiotics and Asthma

Maternal antibiotic use in pregnancy

associated with 89 increased risk

of childhood asthma (plt00001)

Medscape ObGyn Womenrsquos Health November 27 2016

Coverage from the American College of Allergy Asthma amp

Immunology (ACAAI) 2016 Annual Scientific Meeting

httpwwwmedscapecomviewarticle872028nlid=110951_25

81ampsrc=WNL_mdplsnews_161202_mscpedit_obgyampuac=2427

86PXampspon=16ampimpID=1245995ampfaf=1

Asthma and Antibiotics in the First

Year of Life

bull 1-2 Courses 20 increased risk

bull 3-4 Courses 30 increased risk

bull gt 4 Courses 50 increased risk

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Asthma and Antibiotics in the First

Year of Life

bull Risk of asthma was highest in children receiving more than four courses of antibiotics

bull Broad-spectrum cephalosporin use was more common in these subpopulations of children

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Antibiotics and Asthma

bull Adjusted odds ratio of 405 if ABX used in 1st year

of life

bull Adjusted odds ratio of 164 if ABX used after 1st

year of life

Clinical amp Experimental Allergy29(6)1999766ndash771 Antibiotic use in early childhood

and the development of asthma Wickens Pearce Crane et al

DOI 101046j1365-2222199900536x

Over the past four decades there

has been a significant increase in

allergy and asthma in westernized

countries which correlates with

alterations in fecal microbiota

(microflora) and widespread use of

antibiotics

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Pediatrics

Since 1980 the prevalence of many

chronic diseases including Asthma

has nearly tripled

MMWR Surveillance for Asthma -- United States 1960-1995

Mannino DM Homa DM Pertowski CA

httpswwwcdcgovmmwrpreviewmmwrhtml00052262htm

Asthma

bull The leading cause of chronic illness in US children

bull One of the fastest growing chronic conditions in developed nations

Population Reference Bureau Childhood Asthma A Growing American Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmericanEpidemicaspx

Asthma

Between 1980-1994

bull The total number of affected children

increased by 75

bull In children younger than 4 years it increased

by 160

Population Reference Bureau Childhood Asthma A Growing American

Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmerica

nEpidemicaspx

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 6: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

The Human Microbiome Project

ndash Nasal passages

ndash Oral cavity

ndash Skin

ndash Gastrointestinal tract

ndash Urogenital tract

httpwwwhmpdaccorg

Ecological Complexity

Metagenomic studies reveal that the

human microbiome is comprised of

an exceedingly complex group of

different ecological niches existing

throughout the body

Nature 2007 Oct 18 449(7164) 804ndash810 The human

microbiome project exploring the microbial part of ourselves in

a changing world Turnbaugh PJ Ley RE Hamady M et al

DOI 101038nature06244

The Supra-Organism

ndash A symbiotic group of human and

microbial cells

ndash Working collectively for the

benefit of the whole

Medical Hypotheses 74(2)2010214215 The human

superorganism ndash Of microbes and men Sleator RD (Ed)

DOI 101016jmehy200908047

The Supra-Organism

A collection of ecosystems

dependent on

ndash Diversity

ndash Balanced ecology

ndash Symbiosis

Genome Biology 201314R1 Biogeography of the

ecosystems of the healthy human body Zhou Y Gao

H Mihindukulasuriya KA et al

DOI 101186gb-2013-14-1-r1

The Human Microbiome

The microbial genome complements

the human genome

Nature 2007 Oct 18 449(7164) 804ndash810 The human

microbiome project exploring the microbial part of ourselves in

a changing world Turnbaugh PJ Ley RE Hamady M et al

DOI 101038nature06244

The Human Microbiome

Traits integral to

bull Nutrition

bull Development

bull Immunity

bull Health

PLOSOne June 13 2012 Analyses of the Microbial Diversity

across the Human Microbiome Li K Bihan M Yooseph S et

al

DOI 101371journalpone0032118

The Human Microbiome

Regulates development and

function of the immune system

Cell Host amp Microbe Control of Brain Development Function

and Behavior by the Microbiome Sampson TR Mazmanian

SK

DOI 101016jchom201504011

Colonization

Begins in the placenta

Science Translational Med 21 May 20146(237) 237ra65 The Placenta Harbors a Unique Microbiome Aagaard K Ma J Antony KM et al

DOI 101126scitranslmed3008599

Most Critical Period

Before birth until two years of life

NutrReviews65(6)259-299 Perinatal and Neonatal Manipulation of the Intestinal Microbiome a Note of Caution Neu J

DOI 101111j1753-48872007tb00305x

Medications Damage the

Microbiome

bull Antibiotics antifungals antivirals

bull PPIrsquos

bull Glucocorticosteroids Antihistamines

bull SSRIrsquos HRT Chemotherapy

bull Immunosuppressants Vaccines

Antibiotics

bull Disrupt ecology of the microbiome

bull Alter microbiota via

ndash Overgrowth of resistant organisms

ndash Inhibition and destruction of sensitive

organisms

Science 2012 336(6086)1255-1262 The Application of Ecological Theory

Toward an Understanding of the Human Microbiome Costello EK

Stagaman K Dethlefsen L

DOI 101126science1224203

Antibiotics

Promote fungal (viral) overgrowth

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Antibiotics and Asthma

Maternal antibiotic use in pregnancy

associated with 89 increased risk

of childhood asthma (plt00001)

Medscape ObGyn Womenrsquos Health November 27 2016

Coverage from the American College of Allergy Asthma amp

Immunology (ACAAI) 2016 Annual Scientific Meeting

httpwwwmedscapecomviewarticle872028nlid=110951_25

81ampsrc=WNL_mdplsnews_161202_mscpedit_obgyampuac=2427

86PXampspon=16ampimpID=1245995ampfaf=1

Asthma and Antibiotics in the First

Year of Life

bull 1-2 Courses 20 increased risk

bull 3-4 Courses 30 increased risk

bull gt 4 Courses 50 increased risk

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Asthma and Antibiotics in the First

Year of Life

bull Risk of asthma was highest in children receiving more than four courses of antibiotics

bull Broad-spectrum cephalosporin use was more common in these subpopulations of children

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Antibiotics and Asthma

bull Adjusted odds ratio of 405 if ABX used in 1st year

of life

bull Adjusted odds ratio of 164 if ABX used after 1st

year of life

Clinical amp Experimental Allergy29(6)1999766ndash771 Antibiotic use in early childhood

and the development of asthma Wickens Pearce Crane et al

DOI 101046j1365-2222199900536x

Over the past four decades there

has been a significant increase in

allergy and asthma in westernized

countries which correlates with

alterations in fecal microbiota

(microflora) and widespread use of

antibiotics

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Pediatrics

Since 1980 the prevalence of many

chronic diseases including Asthma

has nearly tripled

MMWR Surveillance for Asthma -- United States 1960-1995

Mannino DM Homa DM Pertowski CA

httpswwwcdcgovmmwrpreviewmmwrhtml00052262htm

Asthma

bull The leading cause of chronic illness in US children

bull One of the fastest growing chronic conditions in developed nations

Population Reference Bureau Childhood Asthma A Growing American Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmericanEpidemicaspx

Asthma

Between 1980-1994

bull The total number of affected children

increased by 75

bull In children younger than 4 years it increased

by 160

Population Reference Bureau Childhood Asthma A Growing American

Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmerica

nEpidemicaspx

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 7: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Ecological Complexity

Metagenomic studies reveal that the

human microbiome is comprised of

an exceedingly complex group of

different ecological niches existing

throughout the body

Nature 2007 Oct 18 449(7164) 804ndash810 The human

microbiome project exploring the microbial part of ourselves in

a changing world Turnbaugh PJ Ley RE Hamady M et al

DOI 101038nature06244

The Supra-Organism

ndash A symbiotic group of human and

microbial cells

ndash Working collectively for the

benefit of the whole

Medical Hypotheses 74(2)2010214215 The human

superorganism ndash Of microbes and men Sleator RD (Ed)

DOI 101016jmehy200908047

The Supra-Organism

A collection of ecosystems

dependent on

ndash Diversity

ndash Balanced ecology

ndash Symbiosis

Genome Biology 201314R1 Biogeography of the

ecosystems of the healthy human body Zhou Y Gao

H Mihindukulasuriya KA et al

DOI 101186gb-2013-14-1-r1

The Human Microbiome

The microbial genome complements

the human genome

Nature 2007 Oct 18 449(7164) 804ndash810 The human

microbiome project exploring the microbial part of ourselves in

a changing world Turnbaugh PJ Ley RE Hamady M et al

DOI 101038nature06244

The Human Microbiome

Traits integral to

bull Nutrition

bull Development

bull Immunity

bull Health

PLOSOne June 13 2012 Analyses of the Microbial Diversity

across the Human Microbiome Li K Bihan M Yooseph S et

al

DOI 101371journalpone0032118

The Human Microbiome

Regulates development and

function of the immune system

Cell Host amp Microbe Control of Brain Development Function

and Behavior by the Microbiome Sampson TR Mazmanian

SK

DOI 101016jchom201504011

Colonization

Begins in the placenta

Science Translational Med 21 May 20146(237) 237ra65 The Placenta Harbors a Unique Microbiome Aagaard K Ma J Antony KM et al

DOI 101126scitranslmed3008599

Most Critical Period

Before birth until two years of life

NutrReviews65(6)259-299 Perinatal and Neonatal Manipulation of the Intestinal Microbiome a Note of Caution Neu J

DOI 101111j1753-48872007tb00305x

Medications Damage the

Microbiome

bull Antibiotics antifungals antivirals

bull PPIrsquos

bull Glucocorticosteroids Antihistamines

bull SSRIrsquos HRT Chemotherapy

bull Immunosuppressants Vaccines

Antibiotics

bull Disrupt ecology of the microbiome

bull Alter microbiota via

ndash Overgrowth of resistant organisms

ndash Inhibition and destruction of sensitive

organisms

Science 2012 336(6086)1255-1262 The Application of Ecological Theory

Toward an Understanding of the Human Microbiome Costello EK

Stagaman K Dethlefsen L

DOI 101126science1224203

Antibiotics

Promote fungal (viral) overgrowth

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Antibiotics and Asthma

Maternal antibiotic use in pregnancy

associated with 89 increased risk

of childhood asthma (plt00001)

Medscape ObGyn Womenrsquos Health November 27 2016

Coverage from the American College of Allergy Asthma amp

Immunology (ACAAI) 2016 Annual Scientific Meeting

httpwwwmedscapecomviewarticle872028nlid=110951_25

81ampsrc=WNL_mdplsnews_161202_mscpedit_obgyampuac=2427

86PXampspon=16ampimpID=1245995ampfaf=1

Asthma and Antibiotics in the First

Year of Life

bull 1-2 Courses 20 increased risk

bull 3-4 Courses 30 increased risk

bull gt 4 Courses 50 increased risk

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Asthma and Antibiotics in the First

Year of Life

bull Risk of asthma was highest in children receiving more than four courses of antibiotics

bull Broad-spectrum cephalosporin use was more common in these subpopulations of children

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Antibiotics and Asthma

bull Adjusted odds ratio of 405 if ABX used in 1st year

of life

bull Adjusted odds ratio of 164 if ABX used after 1st

year of life

Clinical amp Experimental Allergy29(6)1999766ndash771 Antibiotic use in early childhood

and the development of asthma Wickens Pearce Crane et al

DOI 101046j1365-2222199900536x

Over the past four decades there

has been a significant increase in

allergy and asthma in westernized

countries which correlates with

alterations in fecal microbiota

(microflora) and widespread use of

antibiotics

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Pediatrics

Since 1980 the prevalence of many

chronic diseases including Asthma

has nearly tripled

MMWR Surveillance for Asthma -- United States 1960-1995

Mannino DM Homa DM Pertowski CA

httpswwwcdcgovmmwrpreviewmmwrhtml00052262htm

Asthma

bull The leading cause of chronic illness in US children

bull One of the fastest growing chronic conditions in developed nations

Population Reference Bureau Childhood Asthma A Growing American Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmericanEpidemicaspx

Asthma

Between 1980-1994

bull The total number of affected children

increased by 75

bull In children younger than 4 years it increased

by 160

Population Reference Bureau Childhood Asthma A Growing American

Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmerica

nEpidemicaspx

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 8: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

The Supra-Organism

ndash A symbiotic group of human and

microbial cells

ndash Working collectively for the

benefit of the whole

Medical Hypotheses 74(2)2010214215 The human

superorganism ndash Of microbes and men Sleator RD (Ed)

DOI 101016jmehy200908047

The Supra-Organism

A collection of ecosystems

dependent on

ndash Diversity

ndash Balanced ecology

ndash Symbiosis

Genome Biology 201314R1 Biogeography of the

ecosystems of the healthy human body Zhou Y Gao

H Mihindukulasuriya KA et al

DOI 101186gb-2013-14-1-r1

The Human Microbiome

The microbial genome complements

the human genome

Nature 2007 Oct 18 449(7164) 804ndash810 The human

microbiome project exploring the microbial part of ourselves in

a changing world Turnbaugh PJ Ley RE Hamady M et al

DOI 101038nature06244

The Human Microbiome

Traits integral to

bull Nutrition

bull Development

bull Immunity

bull Health

PLOSOne June 13 2012 Analyses of the Microbial Diversity

across the Human Microbiome Li K Bihan M Yooseph S et

al

DOI 101371journalpone0032118

The Human Microbiome

Regulates development and

function of the immune system

Cell Host amp Microbe Control of Brain Development Function

and Behavior by the Microbiome Sampson TR Mazmanian

SK

DOI 101016jchom201504011

Colonization

Begins in the placenta

Science Translational Med 21 May 20146(237) 237ra65 The Placenta Harbors a Unique Microbiome Aagaard K Ma J Antony KM et al

DOI 101126scitranslmed3008599

Most Critical Period

Before birth until two years of life

NutrReviews65(6)259-299 Perinatal and Neonatal Manipulation of the Intestinal Microbiome a Note of Caution Neu J

DOI 101111j1753-48872007tb00305x

Medications Damage the

Microbiome

bull Antibiotics antifungals antivirals

bull PPIrsquos

bull Glucocorticosteroids Antihistamines

bull SSRIrsquos HRT Chemotherapy

bull Immunosuppressants Vaccines

Antibiotics

bull Disrupt ecology of the microbiome

bull Alter microbiota via

ndash Overgrowth of resistant organisms

ndash Inhibition and destruction of sensitive

organisms

Science 2012 336(6086)1255-1262 The Application of Ecological Theory

Toward an Understanding of the Human Microbiome Costello EK

Stagaman K Dethlefsen L

DOI 101126science1224203

Antibiotics

Promote fungal (viral) overgrowth

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Antibiotics and Asthma

Maternal antibiotic use in pregnancy

associated with 89 increased risk

of childhood asthma (plt00001)

Medscape ObGyn Womenrsquos Health November 27 2016

Coverage from the American College of Allergy Asthma amp

Immunology (ACAAI) 2016 Annual Scientific Meeting

httpwwwmedscapecomviewarticle872028nlid=110951_25

81ampsrc=WNL_mdplsnews_161202_mscpedit_obgyampuac=2427

86PXampspon=16ampimpID=1245995ampfaf=1

Asthma and Antibiotics in the First

Year of Life

bull 1-2 Courses 20 increased risk

bull 3-4 Courses 30 increased risk

bull gt 4 Courses 50 increased risk

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Asthma and Antibiotics in the First

Year of Life

bull Risk of asthma was highest in children receiving more than four courses of antibiotics

bull Broad-spectrum cephalosporin use was more common in these subpopulations of children

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Antibiotics and Asthma

bull Adjusted odds ratio of 405 if ABX used in 1st year

of life

bull Adjusted odds ratio of 164 if ABX used after 1st

year of life

Clinical amp Experimental Allergy29(6)1999766ndash771 Antibiotic use in early childhood

and the development of asthma Wickens Pearce Crane et al

DOI 101046j1365-2222199900536x

Over the past four decades there

has been a significant increase in

allergy and asthma in westernized

countries which correlates with

alterations in fecal microbiota

(microflora) and widespread use of

antibiotics

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Pediatrics

Since 1980 the prevalence of many

chronic diseases including Asthma

has nearly tripled

MMWR Surveillance for Asthma -- United States 1960-1995

Mannino DM Homa DM Pertowski CA

httpswwwcdcgovmmwrpreviewmmwrhtml00052262htm

Asthma

bull The leading cause of chronic illness in US children

bull One of the fastest growing chronic conditions in developed nations

Population Reference Bureau Childhood Asthma A Growing American Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmericanEpidemicaspx

Asthma

Between 1980-1994

bull The total number of affected children

increased by 75

bull In children younger than 4 years it increased

by 160

Population Reference Bureau Childhood Asthma A Growing American

Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmerica

nEpidemicaspx

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 9: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

The Supra-Organism

A collection of ecosystems

dependent on

ndash Diversity

ndash Balanced ecology

ndash Symbiosis

Genome Biology 201314R1 Biogeography of the

ecosystems of the healthy human body Zhou Y Gao

H Mihindukulasuriya KA et al

DOI 101186gb-2013-14-1-r1

The Human Microbiome

The microbial genome complements

the human genome

Nature 2007 Oct 18 449(7164) 804ndash810 The human

microbiome project exploring the microbial part of ourselves in

a changing world Turnbaugh PJ Ley RE Hamady M et al

DOI 101038nature06244

The Human Microbiome

Traits integral to

bull Nutrition

bull Development

bull Immunity

bull Health

PLOSOne June 13 2012 Analyses of the Microbial Diversity

across the Human Microbiome Li K Bihan M Yooseph S et

al

DOI 101371journalpone0032118

The Human Microbiome

Regulates development and

function of the immune system

Cell Host amp Microbe Control of Brain Development Function

and Behavior by the Microbiome Sampson TR Mazmanian

SK

DOI 101016jchom201504011

Colonization

Begins in the placenta

Science Translational Med 21 May 20146(237) 237ra65 The Placenta Harbors a Unique Microbiome Aagaard K Ma J Antony KM et al

DOI 101126scitranslmed3008599

Most Critical Period

Before birth until two years of life

NutrReviews65(6)259-299 Perinatal and Neonatal Manipulation of the Intestinal Microbiome a Note of Caution Neu J

DOI 101111j1753-48872007tb00305x

Medications Damage the

Microbiome

bull Antibiotics antifungals antivirals

bull PPIrsquos

bull Glucocorticosteroids Antihistamines

bull SSRIrsquos HRT Chemotherapy

bull Immunosuppressants Vaccines

Antibiotics

bull Disrupt ecology of the microbiome

bull Alter microbiota via

ndash Overgrowth of resistant organisms

ndash Inhibition and destruction of sensitive

organisms

Science 2012 336(6086)1255-1262 The Application of Ecological Theory

Toward an Understanding of the Human Microbiome Costello EK

Stagaman K Dethlefsen L

DOI 101126science1224203

Antibiotics

Promote fungal (viral) overgrowth

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Antibiotics and Asthma

Maternal antibiotic use in pregnancy

associated with 89 increased risk

of childhood asthma (plt00001)

Medscape ObGyn Womenrsquos Health November 27 2016

Coverage from the American College of Allergy Asthma amp

Immunology (ACAAI) 2016 Annual Scientific Meeting

httpwwwmedscapecomviewarticle872028nlid=110951_25

81ampsrc=WNL_mdplsnews_161202_mscpedit_obgyampuac=2427

86PXampspon=16ampimpID=1245995ampfaf=1

Asthma and Antibiotics in the First

Year of Life

bull 1-2 Courses 20 increased risk

bull 3-4 Courses 30 increased risk

bull gt 4 Courses 50 increased risk

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Asthma and Antibiotics in the First

Year of Life

bull Risk of asthma was highest in children receiving more than four courses of antibiotics

bull Broad-spectrum cephalosporin use was more common in these subpopulations of children

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Antibiotics and Asthma

bull Adjusted odds ratio of 405 if ABX used in 1st year

of life

bull Adjusted odds ratio of 164 if ABX used after 1st

year of life

Clinical amp Experimental Allergy29(6)1999766ndash771 Antibiotic use in early childhood

and the development of asthma Wickens Pearce Crane et al

DOI 101046j1365-2222199900536x

Over the past four decades there

has been a significant increase in

allergy and asthma in westernized

countries which correlates with

alterations in fecal microbiota

(microflora) and widespread use of

antibiotics

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Pediatrics

Since 1980 the prevalence of many

chronic diseases including Asthma

has nearly tripled

MMWR Surveillance for Asthma -- United States 1960-1995

Mannino DM Homa DM Pertowski CA

httpswwwcdcgovmmwrpreviewmmwrhtml00052262htm

Asthma

bull The leading cause of chronic illness in US children

bull One of the fastest growing chronic conditions in developed nations

Population Reference Bureau Childhood Asthma A Growing American Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmericanEpidemicaspx

Asthma

Between 1980-1994

bull The total number of affected children

increased by 75

bull In children younger than 4 years it increased

by 160

Population Reference Bureau Childhood Asthma A Growing American

Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmerica

nEpidemicaspx

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 10: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

The Human Microbiome

The microbial genome complements

the human genome

Nature 2007 Oct 18 449(7164) 804ndash810 The human

microbiome project exploring the microbial part of ourselves in

a changing world Turnbaugh PJ Ley RE Hamady M et al

DOI 101038nature06244

The Human Microbiome

Traits integral to

bull Nutrition

bull Development

bull Immunity

bull Health

PLOSOne June 13 2012 Analyses of the Microbial Diversity

across the Human Microbiome Li K Bihan M Yooseph S et

al

DOI 101371journalpone0032118

The Human Microbiome

Regulates development and

function of the immune system

Cell Host amp Microbe Control of Brain Development Function

and Behavior by the Microbiome Sampson TR Mazmanian

SK

DOI 101016jchom201504011

Colonization

Begins in the placenta

Science Translational Med 21 May 20146(237) 237ra65 The Placenta Harbors a Unique Microbiome Aagaard K Ma J Antony KM et al

DOI 101126scitranslmed3008599

Most Critical Period

Before birth until two years of life

NutrReviews65(6)259-299 Perinatal and Neonatal Manipulation of the Intestinal Microbiome a Note of Caution Neu J

DOI 101111j1753-48872007tb00305x

Medications Damage the

Microbiome

bull Antibiotics antifungals antivirals

bull PPIrsquos

bull Glucocorticosteroids Antihistamines

bull SSRIrsquos HRT Chemotherapy

bull Immunosuppressants Vaccines

Antibiotics

bull Disrupt ecology of the microbiome

bull Alter microbiota via

ndash Overgrowth of resistant organisms

ndash Inhibition and destruction of sensitive

organisms

Science 2012 336(6086)1255-1262 The Application of Ecological Theory

Toward an Understanding of the Human Microbiome Costello EK

Stagaman K Dethlefsen L

DOI 101126science1224203

Antibiotics

Promote fungal (viral) overgrowth

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Antibiotics and Asthma

Maternal antibiotic use in pregnancy

associated with 89 increased risk

of childhood asthma (plt00001)

Medscape ObGyn Womenrsquos Health November 27 2016

Coverage from the American College of Allergy Asthma amp

Immunology (ACAAI) 2016 Annual Scientific Meeting

httpwwwmedscapecomviewarticle872028nlid=110951_25

81ampsrc=WNL_mdplsnews_161202_mscpedit_obgyampuac=2427

86PXampspon=16ampimpID=1245995ampfaf=1

Asthma and Antibiotics in the First

Year of Life

bull 1-2 Courses 20 increased risk

bull 3-4 Courses 30 increased risk

bull gt 4 Courses 50 increased risk

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Asthma and Antibiotics in the First

Year of Life

bull Risk of asthma was highest in children receiving more than four courses of antibiotics

bull Broad-spectrum cephalosporin use was more common in these subpopulations of children

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Antibiotics and Asthma

bull Adjusted odds ratio of 405 if ABX used in 1st year

of life

bull Adjusted odds ratio of 164 if ABX used after 1st

year of life

Clinical amp Experimental Allergy29(6)1999766ndash771 Antibiotic use in early childhood

and the development of asthma Wickens Pearce Crane et al

DOI 101046j1365-2222199900536x

Over the past four decades there

has been a significant increase in

allergy and asthma in westernized

countries which correlates with

alterations in fecal microbiota

(microflora) and widespread use of

antibiotics

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Pediatrics

Since 1980 the prevalence of many

chronic diseases including Asthma

has nearly tripled

MMWR Surveillance for Asthma -- United States 1960-1995

Mannino DM Homa DM Pertowski CA

httpswwwcdcgovmmwrpreviewmmwrhtml00052262htm

Asthma

bull The leading cause of chronic illness in US children

bull One of the fastest growing chronic conditions in developed nations

Population Reference Bureau Childhood Asthma A Growing American Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmericanEpidemicaspx

Asthma

Between 1980-1994

bull The total number of affected children

increased by 75

bull In children younger than 4 years it increased

by 160

Population Reference Bureau Childhood Asthma A Growing American

Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmerica

nEpidemicaspx

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 11: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

The Human Microbiome

Traits integral to

bull Nutrition

bull Development

bull Immunity

bull Health

PLOSOne June 13 2012 Analyses of the Microbial Diversity

across the Human Microbiome Li K Bihan M Yooseph S et

al

DOI 101371journalpone0032118

The Human Microbiome

Regulates development and

function of the immune system

Cell Host amp Microbe Control of Brain Development Function

and Behavior by the Microbiome Sampson TR Mazmanian

SK

DOI 101016jchom201504011

Colonization

Begins in the placenta

Science Translational Med 21 May 20146(237) 237ra65 The Placenta Harbors a Unique Microbiome Aagaard K Ma J Antony KM et al

DOI 101126scitranslmed3008599

Most Critical Period

Before birth until two years of life

NutrReviews65(6)259-299 Perinatal and Neonatal Manipulation of the Intestinal Microbiome a Note of Caution Neu J

DOI 101111j1753-48872007tb00305x

Medications Damage the

Microbiome

bull Antibiotics antifungals antivirals

bull PPIrsquos

bull Glucocorticosteroids Antihistamines

bull SSRIrsquos HRT Chemotherapy

bull Immunosuppressants Vaccines

Antibiotics

bull Disrupt ecology of the microbiome

bull Alter microbiota via

ndash Overgrowth of resistant organisms

ndash Inhibition and destruction of sensitive

organisms

Science 2012 336(6086)1255-1262 The Application of Ecological Theory

Toward an Understanding of the Human Microbiome Costello EK

Stagaman K Dethlefsen L

DOI 101126science1224203

Antibiotics

Promote fungal (viral) overgrowth

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Antibiotics and Asthma

Maternal antibiotic use in pregnancy

associated with 89 increased risk

of childhood asthma (plt00001)

Medscape ObGyn Womenrsquos Health November 27 2016

Coverage from the American College of Allergy Asthma amp

Immunology (ACAAI) 2016 Annual Scientific Meeting

httpwwwmedscapecomviewarticle872028nlid=110951_25

81ampsrc=WNL_mdplsnews_161202_mscpedit_obgyampuac=2427

86PXampspon=16ampimpID=1245995ampfaf=1

Asthma and Antibiotics in the First

Year of Life

bull 1-2 Courses 20 increased risk

bull 3-4 Courses 30 increased risk

bull gt 4 Courses 50 increased risk

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Asthma and Antibiotics in the First

Year of Life

bull Risk of asthma was highest in children receiving more than four courses of antibiotics

bull Broad-spectrum cephalosporin use was more common in these subpopulations of children

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Antibiotics and Asthma

bull Adjusted odds ratio of 405 if ABX used in 1st year

of life

bull Adjusted odds ratio of 164 if ABX used after 1st

year of life

Clinical amp Experimental Allergy29(6)1999766ndash771 Antibiotic use in early childhood

and the development of asthma Wickens Pearce Crane et al

DOI 101046j1365-2222199900536x

Over the past four decades there

has been a significant increase in

allergy and asthma in westernized

countries which correlates with

alterations in fecal microbiota

(microflora) and widespread use of

antibiotics

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Pediatrics

Since 1980 the prevalence of many

chronic diseases including Asthma

has nearly tripled

MMWR Surveillance for Asthma -- United States 1960-1995

Mannino DM Homa DM Pertowski CA

httpswwwcdcgovmmwrpreviewmmwrhtml00052262htm

Asthma

bull The leading cause of chronic illness in US children

bull One of the fastest growing chronic conditions in developed nations

Population Reference Bureau Childhood Asthma A Growing American Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmericanEpidemicaspx

Asthma

Between 1980-1994

bull The total number of affected children

increased by 75

bull In children younger than 4 years it increased

by 160

Population Reference Bureau Childhood Asthma A Growing American

Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmerica

nEpidemicaspx

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 12: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

The Human Microbiome

Regulates development and

function of the immune system

Cell Host amp Microbe Control of Brain Development Function

and Behavior by the Microbiome Sampson TR Mazmanian

SK

DOI 101016jchom201504011

Colonization

Begins in the placenta

Science Translational Med 21 May 20146(237) 237ra65 The Placenta Harbors a Unique Microbiome Aagaard K Ma J Antony KM et al

DOI 101126scitranslmed3008599

Most Critical Period

Before birth until two years of life

NutrReviews65(6)259-299 Perinatal and Neonatal Manipulation of the Intestinal Microbiome a Note of Caution Neu J

DOI 101111j1753-48872007tb00305x

Medications Damage the

Microbiome

bull Antibiotics antifungals antivirals

bull PPIrsquos

bull Glucocorticosteroids Antihistamines

bull SSRIrsquos HRT Chemotherapy

bull Immunosuppressants Vaccines

Antibiotics

bull Disrupt ecology of the microbiome

bull Alter microbiota via

ndash Overgrowth of resistant organisms

ndash Inhibition and destruction of sensitive

organisms

Science 2012 336(6086)1255-1262 The Application of Ecological Theory

Toward an Understanding of the Human Microbiome Costello EK

Stagaman K Dethlefsen L

DOI 101126science1224203

Antibiotics

Promote fungal (viral) overgrowth

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Antibiotics and Asthma

Maternal antibiotic use in pregnancy

associated with 89 increased risk

of childhood asthma (plt00001)

Medscape ObGyn Womenrsquos Health November 27 2016

Coverage from the American College of Allergy Asthma amp

Immunology (ACAAI) 2016 Annual Scientific Meeting

httpwwwmedscapecomviewarticle872028nlid=110951_25

81ampsrc=WNL_mdplsnews_161202_mscpedit_obgyampuac=2427

86PXampspon=16ampimpID=1245995ampfaf=1

Asthma and Antibiotics in the First

Year of Life

bull 1-2 Courses 20 increased risk

bull 3-4 Courses 30 increased risk

bull gt 4 Courses 50 increased risk

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Asthma and Antibiotics in the First

Year of Life

bull Risk of asthma was highest in children receiving more than four courses of antibiotics

bull Broad-spectrum cephalosporin use was more common in these subpopulations of children

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Antibiotics and Asthma

bull Adjusted odds ratio of 405 if ABX used in 1st year

of life

bull Adjusted odds ratio of 164 if ABX used after 1st

year of life

Clinical amp Experimental Allergy29(6)1999766ndash771 Antibiotic use in early childhood

and the development of asthma Wickens Pearce Crane et al

DOI 101046j1365-2222199900536x

Over the past four decades there

has been a significant increase in

allergy and asthma in westernized

countries which correlates with

alterations in fecal microbiota

(microflora) and widespread use of

antibiotics

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Pediatrics

Since 1980 the prevalence of many

chronic diseases including Asthma

has nearly tripled

MMWR Surveillance for Asthma -- United States 1960-1995

Mannino DM Homa DM Pertowski CA

httpswwwcdcgovmmwrpreviewmmwrhtml00052262htm

Asthma

bull The leading cause of chronic illness in US children

bull One of the fastest growing chronic conditions in developed nations

Population Reference Bureau Childhood Asthma A Growing American Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmericanEpidemicaspx

Asthma

Between 1980-1994

bull The total number of affected children

increased by 75

bull In children younger than 4 years it increased

by 160

Population Reference Bureau Childhood Asthma A Growing American

Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmerica

nEpidemicaspx

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 13: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Colonization

Begins in the placenta

Science Translational Med 21 May 20146(237) 237ra65 The Placenta Harbors a Unique Microbiome Aagaard K Ma J Antony KM et al

DOI 101126scitranslmed3008599

Most Critical Period

Before birth until two years of life

NutrReviews65(6)259-299 Perinatal and Neonatal Manipulation of the Intestinal Microbiome a Note of Caution Neu J

DOI 101111j1753-48872007tb00305x

Medications Damage the

Microbiome

bull Antibiotics antifungals antivirals

bull PPIrsquos

bull Glucocorticosteroids Antihistamines

bull SSRIrsquos HRT Chemotherapy

bull Immunosuppressants Vaccines

Antibiotics

bull Disrupt ecology of the microbiome

bull Alter microbiota via

ndash Overgrowth of resistant organisms

ndash Inhibition and destruction of sensitive

organisms

Science 2012 336(6086)1255-1262 The Application of Ecological Theory

Toward an Understanding of the Human Microbiome Costello EK

Stagaman K Dethlefsen L

DOI 101126science1224203

Antibiotics

Promote fungal (viral) overgrowth

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Antibiotics and Asthma

Maternal antibiotic use in pregnancy

associated with 89 increased risk

of childhood asthma (plt00001)

Medscape ObGyn Womenrsquos Health November 27 2016

Coverage from the American College of Allergy Asthma amp

Immunology (ACAAI) 2016 Annual Scientific Meeting

httpwwwmedscapecomviewarticle872028nlid=110951_25

81ampsrc=WNL_mdplsnews_161202_mscpedit_obgyampuac=2427

86PXampspon=16ampimpID=1245995ampfaf=1

Asthma and Antibiotics in the First

Year of Life

bull 1-2 Courses 20 increased risk

bull 3-4 Courses 30 increased risk

bull gt 4 Courses 50 increased risk

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Asthma and Antibiotics in the First

Year of Life

bull Risk of asthma was highest in children receiving more than four courses of antibiotics

bull Broad-spectrum cephalosporin use was more common in these subpopulations of children

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Antibiotics and Asthma

bull Adjusted odds ratio of 405 if ABX used in 1st year

of life

bull Adjusted odds ratio of 164 if ABX used after 1st

year of life

Clinical amp Experimental Allergy29(6)1999766ndash771 Antibiotic use in early childhood

and the development of asthma Wickens Pearce Crane et al

DOI 101046j1365-2222199900536x

Over the past four decades there

has been a significant increase in

allergy and asthma in westernized

countries which correlates with

alterations in fecal microbiota

(microflora) and widespread use of

antibiotics

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Pediatrics

Since 1980 the prevalence of many

chronic diseases including Asthma

has nearly tripled

MMWR Surveillance for Asthma -- United States 1960-1995

Mannino DM Homa DM Pertowski CA

httpswwwcdcgovmmwrpreviewmmwrhtml00052262htm

Asthma

bull The leading cause of chronic illness in US children

bull One of the fastest growing chronic conditions in developed nations

Population Reference Bureau Childhood Asthma A Growing American Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmericanEpidemicaspx

Asthma

Between 1980-1994

bull The total number of affected children

increased by 75

bull In children younger than 4 years it increased

by 160

Population Reference Bureau Childhood Asthma A Growing American

Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmerica

nEpidemicaspx

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 14: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Most Critical Period

Before birth until two years of life

NutrReviews65(6)259-299 Perinatal and Neonatal Manipulation of the Intestinal Microbiome a Note of Caution Neu J

DOI 101111j1753-48872007tb00305x

Medications Damage the

Microbiome

bull Antibiotics antifungals antivirals

bull PPIrsquos

bull Glucocorticosteroids Antihistamines

bull SSRIrsquos HRT Chemotherapy

bull Immunosuppressants Vaccines

Antibiotics

bull Disrupt ecology of the microbiome

bull Alter microbiota via

ndash Overgrowth of resistant organisms

ndash Inhibition and destruction of sensitive

organisms

Science 2012 336(6086)1255-1262 The Application of Ecological Theory

Toward an Understanding of the Human Microbiome Costello EK

Stagaman K Dethlefsen L

DOI 101126science1224203

Antibiotics

Promote fungal (viral) overgrowth

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Antibiotics and Asthma

Maternal antibiotic use in pregnancy

associated with 89 increased risk

of childhood asthma (plt00001)

Medscape ObGyn Womenrsquos Health November 27 2016

Coverage from the American College of Allergy Asthma amp

Immunology (ACAAI) 2016 Annual Scientific Meeting

httpwwwmedscapecomviewarticle872028nlid=110951_25

81ampsrc=WNL_mdplsnews_161202_mscpedit_obgyampuac=2427

86PXampspon=16ampimpID=1245995ampfaf=1

Asthma and Antibiotics in the First

Year of Life

bull 1-2 Courses 20 increased risk

bull 3-4 Courses 30 increased risk

bull gt 4 Courses 50 increased risk

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Asthma and Antibiotics in the First

Year of Life

bull Risk of asthma was highest in children receiving more than four courses of antibiotics

bull Broad-spectrum cephalosporin use was more common in these subpopulations of children

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Antibiotics and Asthma

bull Adjusted odds ratio of 405 if ABX used in 1st year

of life

bull Adjusted odds ratio of 164 if ABX used after 1st

year of life

Clinical amp Experimental Allergy29(6)1999766ndash771 Antibiotic use in early childhood

and the development of asthma Wickens Pearce Crane et al

DOI 101046j1365-2222199900536x

Over the past four decades there

has been a significant increase in

allergy and asthma in westernized

countries which correlates with

alterations in fecal microbiota

(microflora) and widespread use of

antibiotics

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Pediatrics

Since 1980 the prevalence of many

chronic diseases including Asthma

has nearly tripled

MMWR Surveillance for Asthma -- United States 1960-1995

Mannino DM Homa DM Pertowski CA

httpswwwcdcgovmmwrpreviewmmwrhtml00052262htm

Asthma

bull The leading cause of chronic illness in US children

bull One of the fastest growing chronic conditions in developed nations

Population Reference Bureau Childhood Asthma A Growing American Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmericanEpidemicaspx

Asthma

Between 1980-1994

bull The total number of affected children

increased by 75

bull In children younger than 4 years it increased

by 160

Population Reference Bureau Childhood Asthma A Growing American

Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmerica

nEpidemicaspx

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 15: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Medications Damage the

Microbiome

bull Antibiotics antifungals antivirals

bull PPIrsquos

bull Glucocorticosteroids Antihistamines

bull SSRIrsquos HRT Chemotherapy

bull Immunosuppressants Vaccines

Antibiotics

bull Disrupt ecology of the microbiome

bull Alter microbiota via

ndash Overgrowth of resistant organisms

ndash Inhibition and destruction of sensitive

organisms

Science 2012 336(6086)1255-1262 The Application of Ecological Theory

Toward an Understanding of the Human Microbiome Costello EK

Stagaman K Dethlefsen L

DOI 101126science1224203

Antibiotics

Promote fungal (viral) overgrowth

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Antibiotics and Asthma

Maternal antibiotic use in pregnancy

associated with 89 increased risk

of childhood asthma (plt00001)

Medscape ObGyn Womenrsquos Health November 27 2016

Coverage from the American College of Allergy Asthma amp

Immunology (ACAAI) 2016 Annual Scientific Meeting

httpwwwmedscapecomviewarticle872028nlid=110951_25

81ampsrc=WNL_mdplsnews_161202_mscpedit_obgyampuac=2427

86PXampspon=16ampimpID=1245995ampfaf=1

Asthma and Antibiotics in the First

Year of Life

bull 1-2 Courses 20 increased risk

bull 3-4 Courses 30 increased risk

bull gt 4 Courses 50 increased risk

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Asthma and Antibiotics in the First

Year of Life

bull Risk of asthma was highest in children receiving more than four courses of antibiotics

bull Broad-spectrum cephalosporin use was more common in these subpopulations of children

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Antibiotics and Asthma

bull Adjusted odds ratio of 405 if ABX used in 1st year

of life

bull Adjusted odds ratio of 164 if ABX used after 1st

year of life

Clinical amp Experimental Allergy29(6)1999766ndash771 Antibiotic use in early childhood

and the development of asthma Wickens Pearce Crane et al

DOI 101046j1365-2222199900536x

Over the past four decades there

has been a significant increase in

allergy and asthma in westernized

countries which correlates with

alterations in fecal microbiota

(microflora) and widespread use of

antibiotics

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Pediatrics

Since 1980 the prevalence of many

chronic diseases including Asthma

has nearly tripled

MMWR Surveillance for Asthma -- United States 1960-1995

Mannino DM Homa DM Pertowski CA

httpswwwcdcgovmmwrpreviewmmwrhtml00052262htm

Asthma

bull The leading cause of chronic illness in US children

bull One of the fastest growing chronic conditions in developed nations

Population Reference Bureau Childhood Asthma A Growing American Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmericanEpidemicaspx

Asthma

Between 1980-1994

bull The total number of affected children

increased by 75

bull In children younger than 4 years it increased

by 160

Population Reference Bureau Childhood Asthma A Growing American

Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmerica

nEpidemicaspx

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 16: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Antibiotics

bull Disrupt ecology of the microbiome

bull Alter microbiota via

ndash Overgrowth of resistant organisms

ndash Inhibition and destruction of sensitive

organisms

Science 2012 336(6086)1255-1262 The Application of Ecological Theory

Toward an Understanding of the Human Microbiome Costello EK

Stagaman K Dethlefsen L

DOI 101126science1224203

Antibiotics

Promote fungal (viral) overgrowth

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Antibiotics and Asthma

Maternal antibiotic use in pregnancy

associated with 89 increased risk

of childhood asthma (plt00001)

Medscape ObGyn Womenrsquos Health November 27 2016

Coverage from the American College of Allergy Asthma amp

Immunology (ACAAI) 2016 Annual Scientific Meeting

httpwwwmedscapecomviewarticle872028nlid=110951_25

81ampsrc=WNL_mdplsnews_161202_mscpedit_obgyampuac=2427

86PXampspon=16ampimpID=1245995ampfaf=1

Asthma and Antibiotics in the First

Year of Life

bull 1-2 Courses 20 increased risk

bull 3-4 Courses 30 increased risk

bull gt 4 Courses 50 increased risk

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Asthma and Antibiotics in the First

Year of Life

bull Risk of asthma was highest in children receiving more than four courses of antibiotics

bull Broad-spectrum cephalosporin use was more common in these subpopulations of children

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Antibiotics and Asthma

bull Adjusted odds ratio of 405 if ABX used in 1st year

of life

bull Adjusted odds ratio of 164 if ABX used after 1st

year of life

Clinical amp Experimental Allergy29(6)1999766ndash771 Antibiotic use in early childhood

and the development of asthma Wickens Pearce Crane et al

DOI 101046j1365-2222199900536x

Over the past four decades there

has been a significant increase in

allergy and asthma in westernized

countries which correlates with

alterations in fecal microbiota

(microflora) and widespread use of

antibiotics

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Pediatrics

Since 1980 the prevalence of many

chronic diseases including Asthma

has nearly tripled

MMWR Surveillance for Asthma -- United States 1960-1995

Mannino DM Homa DM Pertowski CA

httpswwwcdcgovmmwrpreviewmmwrhtml00052262htm

Asthma

bull The leading cause of chronic illness in US children

bull One of the fastest growing chronic conditions in developed nations

Population Reference Bureau Childhood Asthma A Growing American Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmericanEpidemicaspx

Asthma

Between 1980-1994

bull The total number of affected children

increased by 75

bull In children younger than 4 years it increased

by 160

Population Reference Bureau Childhood Asthma A Growing American

Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmerica

nEpidemicaspx

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 17: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Antibiotics

Promote fungal (viral) overgrowth

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Antibiotics and Asthma

Maternal antibiotic use in pregnancy

associated with 89 increased risk

of childhood asthma (plt00001)

Medscape ObGyn Womenrsquos Health November 27 2016

Coverage from the American College of Allergy Asthma amp

Immunology (ACAAI) 2016 Annual Scientific Meeting

httpwwwmedscapecomviewarticle872028nlid=110951_25

81ampsrc=WNL_mdplsnews_161202_mscpedit_obgyampuac=2427

86PXampspon=16ampimpID=1245995ampfaf=1

Asthma and Antibiotics in the First

Year of Life

bull 1-2 Courses 20 increased risk

bull 3-4 Courses 30 increased risk

bull gt 4 Courses 50 increased risk

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Asthma and Antibiotics in the First

Year of Life

bull Risk of asthma was highest in children receiving more than four courses of antibiotics

bull Broad-spectrum cephalosporin use was more common in these subpopulations of children

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Antibiotics and Asthma

bull Adjusted odds ratio of 405 if ABX used in 1st year

of life

bull Adjusted odds ratio of 164 if ABX used after 1st

year of life

Clinical amp Experimental Allergy29(6)1999766ndash771 Antibiotic use in early childhood

and the development of asthma Wickens Pearce Crane et al

DOI 101046j1365-2222199900536x

Over the past four decades there

has been a significant increase in

allergy and asthma in westernized

countries which correlates with

alterations in fecal microbiota

(microflora) and widespread use of

antibiotics

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Pediatrics

Since 1980 the prevalence of many

chronic diseases including Asthma

has nearly tripled

MMWR Surveillance for Asthma -- United States 1960-1995

Mannino DM Homa DM Pertowski CA

httpswwwcdcgovmmwrpreviewmmwrhtml00052262htm

Asthma

bull The leading cause of chronic illness in US children

bull One of the fastest growing chronic conditions in developed nations

Population Reference Bureau Childhood Asthma A Growing American Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmericanEpidemicaspx

Asthma

Between 1980-1994

bull The total number of affected children

increased by 75

bull In children younger than 4 years it increased

by 160

Population Reference Bureau Childhood Asthma A Growing American

Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmerica

nEpidemicaspx

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 18: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Antibiotics and Asthma

Maternal antibiotic use in pregnancy

associated with 89 increased risk

of childhood asthma (plt00001)

Medscape ObGyn Womenrsquos Health November 27 2016

Coverage from the American College of Allergy Asthma amp

Immunology (ACAAI) 2016 Annual Scientific Meeting

httpwwwmedscapecomviewarticle872028nlid=110951_25

81ampsrc=WNL_mdplsnews_161202_mscpedit_obgyampuac=2427

86PXampspon=16ampimpID=1245995ampfaf=1

Asthma and Antibiotics in the First

Year of Life

bull 1-2 Courses 20 increased risk

bull 3-4 Courses 30 increased risk

bull gt 4 Courses 50 increased risk

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Asthma and Antibiotics in the First

Year of Life

bull Risk of asthma was highest in children receiving more than four courses of antibiotics

bull Broad-spectrum cephalosporin use was more common in these subpopulations of children

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Antibiotics and Asthma

bull Adjusted odds ratio of 405 if ABX used in 1st year

of life

bull Adjusted odds ratio of 164 if ABX used after 1st

year of life

Clinical amp Experimental Allergy29(6)1999766ndash771 Antibiotic use in early childhood

and the development of asthma Wickens Pearce Crane et al

DOI 101046j1365-2222199900536x

Over the past four decades there

has been a significant increase in

allergy and asthma in westernized

countries which correlates with

alterations in fecal microbiota

(microflora) and widespread use of

antibiotics

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Pediatrics

Since 1980 the prevalence of many

chronic diseases including Asthma

has nearly tripled

MMWR Surveillance for Asthma -- United States 1960-1995

Mannino DM Homa DM Pertowski CA

httpswwwcdcgovmmwrpreviewmmwrhtml00052262htm

Asthma

bull The leading cause of chronic illness in US children

bull One of the fastest growing chronic conditions in developed nations

Population Reference Bureau Childhood Asthma A Growing American Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmericanEpidemicaspx

Asthma

Between 1980-1994

bull The total number of affected children

increased by 75

bull In children younger than 4 years it increased

by 160

Population Reference Bureau Childhood Asthma A Growing American

Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmerica

nEpidemicaspx

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 19: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Asthma and Antibiotics in the First

Year of Life

bull 1-2 Courses 20 increased risk

bull 3-4 Courses 30 increased risk

bull gt 4 Courses 50 increased risk

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Asthma and Antibiotics in the First

Year of Life

bull Risk of asthma was highest in children receiving more than four courses of antibiotics

bull Broad-spectrum cephalosporin use was more common in these subpopulations of children

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Antibiotics and Asthma

bull Adjusted odds ratio of 405 if ABX used in 1st year

of life

bull Adjusted odds ratio of 164 if ABX used after 1st

year of life

Clinical amp Experimental Allergy29(6)1999766ndash771 Antibiotic use in early childhood

and the development of asthma Wickens Pearce Crane et al

DOI 101046j1365-2222199900536x

Over the past four decades there

has been a significant increase in

allergy and asthma in westernized

countries which correlates with

alterations in fecal microbiota

(microflora) and widespread use of

antibiotics

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Pediatrics

Since 1980 the prevalence of many

chronic diseases including Asthma

has nearly tripled

MMWR Surveillance for Asthma -- United States 1960-1995

Mannino DM Homa DM Pertowski CA

httpswwwcdcgovmmwrpreviewmmwrhtml00052262htm

Asthma

bull The leading cause of chronic illness in US children

bull One of the fastest growing chronic conditions in developed nations

Population Reference Bureau Childhood Asthma A Growing American Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmericanEpidemicaspx

Asthma

Between 1980-1994

bull The total number of affected children

increased by 75

bull In children younger than 4 years it increased

by 160

Population Reference Bureau Childhood Asthma A Growing American

Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmerica

nEpidemicaspx

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 20: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Asthma and Antibiotics in the First

Year of Life

bull Risk of asthma was highest in children receiving more than four courses of antibiotics

bull Broad-spectrum cephalosporin use was more common in these subpopulations of children

Chest 2007131(6)1753-9 Increased risk of childhood asthma from antibiotic use in early life Kozyrskyj AL Ernst P Becker AB

DOI 101378chest06-3008

Antibiotics and Asthma

bull Adjusted odds ratio of 405 if ABX used in 1st year

of life

bull Adjusted odds ratio of 164 if ABX used after 1st

year of life

Clinical amp Experimental Allergy29(6)1999766ndash771 Antibiotic use in early childhood

and the development of asthma Wickens Pearce Crane et al

DOI 101046j1365-2222199900536x

Over the past four decades there

has been a significant increase in

allergy and asthma in westernized

countries which correlates with

alterations in fecal microbiota

(microflora) and widespread use of

antibiotics

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Pediatrics

Since 1980 the prevalence of many

chronic diseases including Asthma

has nearly tripled

MMWR Surveillance for Asthma -- United States 1960-1995

Mannino DM Homa DM Pertowski CA

httpswwwcdcgovmmwrpreviewmmwrhtml00052262htm

Asthma

bull The leading cause of chronic illness in US children

bull One of the fastest growing chronic conditions in developed nations

Population Reference Bureau Childhood Asthma A Growing American Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmericanEpidemicaspx

Asthma

Between 1980-1994

bull The total number of affected children

increased by 75

bull In children younger than 4 years it increased

by 160

Population Reference Bureau Childhood Asthma A Growing American

Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmerica

nEpidemicaspx

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 21: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Antibiotics and Asthma

bull Adjusted odds ratio of 405 if ABX used in 1st year

of life

bull Adjusted odds ratio of 164 if ABX used after 1st

year of life

Clinical amp Experimental Allergy29(6)1999766ndash771 Antibiotic use in early childhood

and the development of asthma Wickens Pearce Crane et al

DOI 101046j1365-2222199900536x

Over the past four decades there

has been a significant increase in

allergy and asthma in westernized

countries which correlates with

alterations in fecal microbiota

(microflora) and widespread use of

antibiotics

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Pediatrics

Since 1980 the prevalence of many

chronic diseases including Asthma

has nearly tripled

MMWR Surveillance for Asthma -- United States 1960-1995

Mannino DM Homa DM Pertowski CA

httpswwwcdcgovmmwrpreviewmmwrhtml00052262htm

Asthma

bull The leading cause of chronic illness in US children

bull One of the fastest growing chronic conditions in developed nations

Population Reference Bureau Childhood Asthma A Growing American Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmericanEpidemicaspx

Asthma

Between 1980-1994

bull The total number of affected children

increased by 75

bull In children younger than 4 years it increased

by 160

Population Reference Bureau Childhood Asthma A Growing American

Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmerica

nEpidemicaspx

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 22: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Over the past four decades there

has been a significant increase in

allergy and asthma in westernized

countries which correlates with

alterations in fecal microbiota

(microflora) and widespread use of

antibiotics

Infect Immune 200472(9) 4996ndash5003 Role of Antibiotics

and Fungal Microbiota in Driving Pulmonary Allergic

Responses Noverr MC Noggle RM Toews GB et al

DOI 101128IAI7294996-50032004

Pediatrics

Since 1980 the prevalence of many

chronic diseases including Asthma

has nearly tripled

MMWR Surveillance for Asthma -- United States 1960-1995

Mannino DM Homa DM Pertowski CA

httpswwwcdcgovmmwrpreviewmmwrhtml00052262htm

Asthma

bull The leading cause of chronic illness in US children

bull One of the fastest growing chronic conditions in developed nations

Population Reference Bureau Childhood Asthma A Growing American Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmericanEpidemicaspx

Asthma

Between 1980-1994

bull The total number of affected children

increased by 75

bull In children younger than 4 years it increased

by 160

Population Reference Bureau Childhood Asthma A Growing American

Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmerica

nEpidemicaspx

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 23: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Pediatrics

Since 1980 the prevalence of many

chronic diseases including Asthma

has nearly tripled

MMWR Surveillance for Asthma -- United States 1960-1995

Mannino DM Homa DM Pertowski CA

httpswwwcdcgovmmwrpreviewmmwrhtml00052262htm

Asthma

bull The leading cause of chronic illness in US children

bull One of the fastest growing chronic conditions in developed nations

Population Reference Bureau Childhood Asthma A Growing American Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmericanEpidemicaspx

Asthma

Between 1980-1994

bull The total number of affected children

increased by 75

bull In children younger than 4 years it increased

by 160

Population Reference Bureau Childhood Asthma A Growing American

Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmerica

nEpidemicaspx

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 24: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Asthma

bull The leading cause of chronic illness in US children

bull One of the fastest growing chronic conditions in developed nations

Population Reference Bureau Childhood Asthma A Growing American Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmericanEpidemicaspx

Asthma

Between 1980-1994

bull The total number of affected children

increased by 75

bull In children younger than 4 years it increased

by 160

Population Reference Bureau Childhood Asthma A Growing American

Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmerica

nEpidemicaspx

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 25: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Asthma

Between 1980-1994

bull The total number of affected children

increased by 75

bull In children younger than 4 years it increased

by 160

Population Reference Bureau Childhood Asthma A Growing American

Epidemic

Carlson JE Stroebel C

httpwwwprborgPublicationsArticles2001ChildhoodAsthmaAGrowingAmerica

nEpidemicaspx

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 26: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Antibiotics

Use in the first year of life associated with increased

risks of asthma rhino-conjunctivitis and eczema

J Allerg Clin Immunol 2009124(5)982ndash989 Antibiotic use in infancy and symptoms of

asthma rhinoconjunctivitis and eczema in children 6 and 7 years old International

Study of Asthma and Allergies in Childhood Phase III Foliiaki S Pearce N Bjorksten B

DOI 101016jjaci200908017

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 27: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Pediatrics

The Incidence of skin and food

allergies nearly doubled between

1997 - 2011

NCHS Data Brief Trends in Allergic Conditions Among

Children United States 1997ndash2011 Jackson KD Howie LD

Akinbami LJ

httpwwwcdcgovnchsdatadatabriefsdb121pdf

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 28: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Allergies and the Microbiome

Studies using animal models of

allergy have provided direct evidence

that a robust microbiome provides

protection against allergic responses

Encyclopedia of Immunobiology Microbiome and

Allergy5336ndash345 Oxford Academic Press 2016 Esser-von

Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 29: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Allergies and the Microbiome

A lifestyle characterized by high standards of

hygiene overuse of antibiotics and the

consumption of highly processed foods is

associated with a high incidence of allergic diseases

Encyclopedia of Immunobiology Microbiome and Allergy5336ndash345 Oxford

Academic Press 2016 Esser-von Bierren J Harris N

DOI 101016B978-0-12-374279-716005-9

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 30: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Atopy in Anthroposophically

Raised Children

Lower Prevalence of atopy than in children from

conventional families

ndash Fewer vaccinations

ndash Fewer antibiotics

ndash Higher levels of probiotics in diet

ndash More use of homeopathy

Lancet 19993531485-88 Atopy in children of families with an anthroposophic lifestyle

Alm JS Swartz J Lilja G et al

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 31: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Diversity of Microbiome

ldquoDiversity dictates the stability of

ecosystemsrdquo

Science 06 July 2007 Stability and Diversity of Ecosystems

Ives AR Carpenter SR

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 32: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Diversity in the Gut

Rich balanced and diverse bacterial communities seem to be perceived as ldquoselfrdquo and induce a quick maturation of the immune system and gut responses

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 33: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Diversity in the Gut

Poor and unbalanced bacterial communities are apparently perceived as ldquonon-selfrdquo and induce inflammatory responses aimed at eliminating it

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 34: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Diversity in the Gut

bull Diversity reduces inflammation

bull Lack of diversity (dysbiosis) triggers inflammation

Immunity 41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 35: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Dysbiosis

bull The opposite of Symbiosis

bull An ecological imbalance between

organisms within the ecology of

the microbiome

bull Inversely proportional to diversity

Altern Med Rev 20049(2)180-197 The Causes of Intestinal

Dysbiosis A Review Hawrelak JA Myers SP

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 36: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Dysbiosis

bull Can occur anywhere on body

bull Triggers inflammation

Therapeutic Advances in Gastroenterology May 2013

6(3)215-229 Microbial dysbiosis and colon carcinogenesis

could colon cancer be considered a bacteria-related disease

Sobhani I Amiot A Le Baleur Y

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 37: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Dysbiosis

bull Acute Triggers an adaptive

immune inflammatory response

bull Chronic Drives chronic

inflammatory disease

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 38: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

PPIrsquos and Microbiome

bull Raise gastric pH

bull Alters GI microenvironment

bull Alters growth of organisms

including C difficile

J Hosp Infect 200354(3)243ndash245 Proton pump inhibitors as

a risk factor for Clostridium difficile diarrhoea Cunningham R

Dale B Undy B et al

DOI 101016S0195-6701(03)00088-4

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 39: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Maternal Exposure to PPIrsquos in

Pregnancy and Asthma

bull Danish Population Based Cohort

bull N= 197060

bull Adjusted odds ratio 141 (95 CI 127ndash156)

Aliment Pharm Therapeut 201235(10)1190-1198 Prenatal exposure to acid-

suppressive drugs and the risk of childhood asthma a population-based Danish cohort

study Andersen ABT Erichsen R Farkas DK et al

DOI 101111j1365-2036201205073x

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 40: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Diversity in the Gut

bull Hookworm colonization reduces risk of asthma

bull 9 Studies

bull OR 050 95 CI 028ndash090

Am J Resp Crit Care Med Vol 174 No 5 | Sep 01 2006 Asthma and Current

Intestinal Parasite Infection Systematic Review and Meta-Analysis Leonardi-Bee

J Pritchard D Britton J et al

DOI101164rccm200603-331OC

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 41: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Diversity in the Gut

Whipworm ova therapy induces remissions of

active ulcerative colitis (UC)

Gastroenterology 2005 128(4)825ndash832 Trichuris suis therapy for active

ulcerative colitis A randomized controlled trial Summers RW Elliot DE Urban

JF

DOI 101053jgastro200501005

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 42: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Whipworm Therapy in UC

bull Double Blinded Study

bull N=54

bull 45 vs 17 Improvement

Gastroenterology 2005 128(4)825ndash832 Trichuris

suis therapy for active ulcerative colitis A randomized

controlled trial Summers RW Elliot DE Urban JF

DOI 101053jgastro200501005

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 43: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Malaria and Multiple

Sclerosis

Eradication of malaria in an

otherwise stable population induces

the emergence of Multiple Sclerosis

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 44: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Sardinia Italy

Between 1946ndash1950 the Rockefeller

Foundation conducted a large-scale

Malaria eradication Project

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 45: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Sardinia Italy

267 metric tons of DDT were spread

over the island which entirely

eliminated Malaria

Emerg Infect Dis Program to eradicate malaria in Sardinia

1946ndash1950 Tognotti E 2009 Sep

httpwwwnccdcgoveidarticle15908-1317

DOI 103201eid1509081317

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 46: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Incidence of Multiple Sclerosis

Sardinia Italy

bull Near zero prior to 1960

bull 11100000 in 1965-69

bull 58100000 in 1995-99

Neuroepidemiology 200525(3)129-34 Increasing incidence

of multiple sclerosis in the province of Sassari northern

Sardinia Pugliatti M Riise T Sotgiu MA et al

DOI 101159000086677

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 47: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Incidence of Multiple Sclerosis

Sardinia Italy

bull 97100000 in 2003-07

Mult Scler 201117(11)1282-9 Epidemiology of multiple

sclerosis in south-western Sardinia Cocco E Sardu C Massa

R et al

DOI 1011771352458511408754

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 48: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Current Prevalence of Multiple

Sclerosis

bull 224100000 in Sardinia

bull 90100000 in US

PLOS One 2012 Population Based Study of 12 Autoimmune

Diseases in Sardinia Italy Prevalence and Comorbidity

Sardu C Cocco E Mereu A

DOI 101371journalpone0032487

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 49: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Sardinia Italy

ldquoA dramatically rapid change of the environment

after the eradication of malaria has led the Sardinian

immune system to abnormal responseshellip favoring

increased MS incidence over the last four decades

in Sardinia because of the eradication of malaria 50

years agordquo

Medical Hypotheses 2008 70(4)819-25 Hygiene hypothesis Innate immunity malaria

and multiple sclerosis Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 50: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Sardinia Italy

Eliminating a stablecommensal

parasite in the environment alters the

microbiome and allows the

phenotypic penetration of a disease

of immune dysfunction

Medical Hypotheses 2008 70(4)819-25 Hygiene

hypothesis Innate immunity malaria and multiple sclerosis

Sotgiu S Angius A Embry A et al

DOI 101016jmehy200610069

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 51: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Microbiome and Environment

Rapid environmental changes destabilize the

microbiome triggering dysbiosis and

inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of Immunity

41(1) 2014152ndash165 Foxp3+ T Cells Regulate Immunoglobulin A Selection and

Facilitate Diversification of Bacterial Species Responsible for Immune

Homeostasis Kawamoto S Maruya M Kato LM

DOI 101016jimmuni201405016

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 52: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Implications

The programming (and health) of both the innate

and adaptive immune systems rely heavily on

the diversity the microbiome and the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria

directs maturation of the host immune system Mazmanian SK Liu

CH Tzianabos AO

DOI 101016jcell200505007

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 53: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

ldquoWersquove just spent the better part of a century

doing our unwitting best to wreck the human-

associated microbiota with a multifronted war

on bacteria and a diet notably detrimental to its

well-beingrdquo

NYTimes Magazine May 19 201336-435058-59 Some of My Best Friends

are Bacteria Pollan M

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 54: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

ldquoWe have to stop looking at medicine

as a war between invading

pathogens and our bodiesrdquo

New Yorker Magazine Oct 22 201239-39 Germs are Us

Interview with David A Relman Chief of Infectious Diseases

VA Hospital Palo Alto CA Specter M

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 55: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

The germ theory of diseasehellip is a gross

ldquooversimplificationrdquo

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory

Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 56: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Germ Theory

bull Formulated before any knowledge of the

microbiome

bull All about the eradication of micro-organisms

which is precisely what generates inflammation

The Lancet 291(7551)1077-1081 Limitations of the Germ Theory Stewart T Path FC

DOI 101016S0140-6736(68)91425-6

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 57: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Germ Theory

Ignores the role of ecological diversity in

the microbiome as a foundation of health

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution

of beneficial infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 58: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Germ Theory

Neglects the benefits of infection

ndash Immune system maturation

ndash Diversification of the microbiome

ndash Appropriate inflammation

ndash (Evolution of intracellular organelles)

Trends Ecol Evol 201126(4)202-9 New paradigms for the evolution of beneficial

infections Sachs JL Essenberg CJ Turcotte MM

DOI 101016jtree201101010

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 59: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

ldquoIt goes against [Germ Theory] dogma to think

that bacteria would make our immune systems

function better But the picture is getting very

clear the driving force behind the immune

system are commensalsrdquo

Scientific American June 201237-43 The Ultimate Social Network

Ackerman J

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 60: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Infections

(bacterial viral fungal)

Challenge immune system and microbiome to

develop

bull Tolerance

bull Increase Diversity

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in Infectious Disease and

Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 61: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Infections

Challenge immune system and

microbiome to develop

bull Immunity

bull Appropriate levels of

inflammation

Annu Rev Immunol 2012 30 759ndash795 The Microbiome in

Infectious Disease and Inflammation Honda K Littman DR

DOI 101146annurev-immunol-020711-074937

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 62: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Implications

Without an ecologically diverse microbiome

(impossible without an ecologically diverse

environment) dysbiosis develops and triggers

inflammation

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 63: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Implications

Human health is directly linked to the diversity and

stability of the microbiome and by extension to the

environment

Cell 2005122(1)107-18 An immunomodulatory molecule of symbiotic bacteria directs

maturation of the host immune system Mazmanian SK Liu CH Tzianabos AO

DOI 101016jcell200505007

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 64: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

-Review-

The Human Microbiome

bull The Supra-Organism is part of a complex ecology

between human microbiome and environment

bull Health is simply impossible when microbiome and

environment are damaged

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 65: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Disease

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 66: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Disease

The Leading Cause of Death and

Disability in the US

httpwwwcdcgovchronicdiseaseoverview

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 67: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Disease

ldquoThe great epidemic of our times

responsible for 75 of total health

care costs and the majority of deaths

in the USrdquo

Am J Med 2015 128(4)337ndash343 Health Care 2020

Reengineering Health Care Delivery to Combat Chronic

Disease Milani RV Lavie CJ

DOI httpdxdoiorg101016jamjmed201410047

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 68: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Disease

bull About half of all adultsmdash117 million

peoplemdashhad one or more chronic

health conditions in 2012

bull 25 had two or more chronic

health conditions

Prev Chronic Dis 201411130389 Multiple chronic conditions

among US adults a 2012 update Ward BW Schiller JS

Goodman RA

DOI 105888pcd11130389

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 69: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Diseases

bull Hypertension

bull coronary heart disease

bull Stroke

bull Diabetes

bull Cancer

bull Arthritis

bull Hepatitis

bull Kidneys disease

bull Asthma

bull COPD

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 70: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Causes of Chronic Disease

-Lack of Physical Exercise

-Hypertension

-Hyperlipidemia

-Poor Nutrition

-Tobacco Use

-Excessive Alcohol Use

wwwcdcgovchronicdiseaseoverview

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 71: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Disease

Common denominator inflammation

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease

The growing realization that chronic inflammation is crucial in many diseases

opens new avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 72: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Disease

ldquoInflammation has long been a well-known symptom

of many infectious diseases but molecular and

epidemiological research increasingly suggests that

it is also intimately linked with a broad range of non-

infectious diseases perhaps even all of themrdquo

EMBO Rep 2012 Nov 13(11) 968ndash970 The inflammation theory of disease The

growing realization that chronic inflammation is crucial in many diseases opens new

avenues for treatment Hunter P

DOI 101038embor2012142

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 73: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Disease

ldquoIt is becoming increasingly evident that the lack of

exposure to a variety of microorganisms especially

during early life may result in the development of

diseases such as type 1 diabetes asthma allergies

celiac disease inflammatory bowel disease and

obesityrdquo

J Perinatology (2011) 31 S29ndashS34 The developing intestinal microbiome and its

relationship to health and disease in the neonate Torrazza RM Neu J

DOI101038jp2010172

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 74: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Disease

ldquoAccording to the lsquohygiene hypothesisrsquo the

decreasing incidence of infections in western

countries and more recently in developing countries

is at the origin of the increasing incidence of both

autoimmune and allergic diseasesrdquo

Clin Exp Immunol 2010 Apr 160(1) 1ndash9 The lsquohygiene hypothesisrsquo for autoimmune

and allergic diseases an update Okada H Kuhn C Feillet H et al

DOI 101111j1365-2249201004139x

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 75: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

There is growing evidence that dysbiosis of the

gut microbiota is associated with the

pathogenesis of both intestinal and extra-

intestinal disorders

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 76: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

bull Intestinal disorders include inflammatory bowel

disease irritable bowel syndrome (IBS) and coeliac

disease

bull Extra-intestinal disorders include allergy asthma

metabolic syndrome chronic fatigue cardiovascular

disease autoimmune disorders and obesity

Microbial Ecology in Health amp Disease 2015 2626191

Dysbiosis of the gut microbiota in disease Carding S Verbeke K Vipond DT et al

DOI 103402mehdv2626191

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 77: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Dysbiosis

Antibiotic use is the single most

common and significant cause

Gastroenterol Int 19981129-30 Antibiotic impact on

intestinal microflora Gismondo MR

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 78: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

-Review-

Chronic Disease

bull The leading cause of morbidity and

mortality in the US today

bull A state of chronic inflammation

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 79: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

-Review-

Chronic Disease

bull A result of damage to microbiome

leading to dysbiosis and

inflammation

bull An iatrogenically driven epidemic

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 80: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Lyme Disease

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 81: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Lyme Disease

A chronic inflammatory condition a form of

chronic dysbiosis

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 82: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Lyme Disease

bull A diagnosis often based solely on clinical

judgment rather than on well-defined clinical

criteria and validated laboratory studies

bull AKA Post Lyme Disease Syndrome

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 83: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Lyme Disease

A diagnostic term used in North America and

Europe for patients with persistent pain

neurocognitive symptoms fatigue or all of

these symptoms with or without clinical or

serologic evidence of previous early or late

Lyme disease

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 84: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Lyme Disease

Despite resolution of the objective

manifestations of infection after antibiotic

treatment of Lyme a minority of patients

develop fatigue musculoskeletal pain

difficulties with concentration or short-term

memory or all of these symptoms

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 85: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Lyme Disease

Once the diagnosis is

made patients are

commonly treated for

months to years with

multiple antimicrobial

agents

N Engl J Med 20073571422-1430 A Critical Appraisal of

ldquoChronic Lyme Diseaserdquo Feder HM Johnson BJB

OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 86: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Lyme Disease

No significant difference found between

clinical responses of patients who received

intravenous and oral antibiotics for 90 days

and those who received placebo

N Engl J Med 2001 34585-92 Two Controlled Trials of Antibiotic Treatment in

Patients with Persistent Symptoms and a History of Lyme Disease Klempner

MS Hu LT Evans J et al

DOI 101056NEJM200107123450202

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 87: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Lyme Disease

IV ceftriaxone therapy results in short-term

cognitive improvement for patients with post-

treatment Lyme encephalopathy but relapse in

cognition occurs after the antibiotic is

discontinuedrdquo

Neurology 2008 70(13) 992-1003 A randomized placebo-controlled trial of

repeated IV antibiotic therapy for Lyme encephalopathy Fallon BA Keilp JG

Corbera KMet al

DOI 10121201WNL0000284604611602d

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 88: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Lyme Disease

There is substantial risk with little or no

benefit associated with additional antibiotic

treatment for patients who have long-standing

subjective symptoms after appropriate initial

treatment for an episode of Lyme diseaserdquo

N Engl J Med 20073571422-1430 A Critical Appraisal of ldquoChronic Lyme

Diseaserdquo Feder HM Johnson BJB OConnell S

DOI 101056NEJMra072023

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 89: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Lyme Disease

Antibiotic therapy causes considerable harm to

patients treated for chronic Lyme disease or

postndashLyme disease symptoms

Clin Infect Dis 2006431089-1134 The clinical assessment treatment and

prevention of Lyme disease human granulocytic anaplasmosis and

babesiosis clinical practice guidelines by the Infectious Diseases Society of

America Wormser GP Dattwyler RJ Shapiro ED et al

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 90: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Antibiotics

ldquoAffect various host immune responses

adverselyhellip including leukocyte chemotaxis

lymphocyte and monocyte transformation

antibody production phagocytosis and the

microbicidal action of polymorphonuclear

leukocytesrdquo

Goodman and Gilmans The Pharmacological Basis of Therapeutics 7th

Edition Gilman AG Goodman LS Rall TW et al MacMillan Publishing Co

NY19851084

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 91: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Antibiotics

Temporarily suppress acute inflammation via

nonantimicrobial effects

Europ J Pharmacol Anti-inflammatory effects of macrolide antibiotics Čulić

O Eraković V Parnham MJ

DOI 101016S0014-2999(01)01321-8

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 92: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Antibiotics

Associated with increased risk of

chronic inflammation recurrent

infections and cancer

JAMA 2004291(7)827-835 Antibiotic Use in Relation to

the Risk of Breast Cancer Velicer CM Heckbert SR

Lampe JW et al

DOI101001jama2917827

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 93: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Antibiotics

bull Impair immune system

bull Alter the microbiome

bull Contribute to the development of dysbiosis

bull Promote chronic inflammation

Trends in Immunology33(9) September 2012459ndash466 Antibiotics microbiota and immune defense Ubeda C Pamer EG

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 94: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Lyme

Most cases of are remarkable for

histories of repeated and prolonged

overuse of antibiotics anteceding the

acquisition of Lyme by many years

often beginning in early childhood

Clinical Observation Whitmont RD

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 95: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Lyme

Most cases demonstrate a downward

spiral of worsening clinical

impairment directly proportional to

the length (and spectrum) of

antibiotic therapy

Clinical Observation Whitmont RD

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 96: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Lyme Disease

Etiology

ndash Chronic dysbiosis

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 97: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

-Review-

Chronic Lyme Disease

bull A diverse collection of symptoms

bull A chronic dysbiosis

bull Antibiotic administration worsens

condition

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 98: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Dysbiosis ldquoSolutionsrdquo

bull Use more antibiotics

bull Use probiotics fecal transplants

etc

bull Suppress it with anti-inflammatory

and disease modifying agents

bull Shift paradigmshellip

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 99: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 100: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Homeopathy

bull A 200 year old form of alternative Medicine

bull Currently used by more than 500 million worldwide

bull A form of Nanomedicine

Frontiers in Bioscience 20135(2)685-708 Adaptive network nanomedicine an integrated model for homeopathic medicine Bell I

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 101: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

ldquoIronically one of the most

controversial systems of alternative

medicine homeopathy could turn out to

be one of the oldest and demonstrably

safest forms of nanoparticle based

treatment already used worldwide for

infectious diseasesrdquo

Eur J Integr Med 20135(2)126-40 Advances in Integrative

Nanomedicine for Improving Infectious Disease Treatment in

Public Health Bell IR Schwartz GE Boyer NN et al

DOI 101016jeujim201211002

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 102: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Homeopathy

Historically interpreted within a

vitalistic and spiritual conceptual

framework common in the 18th

Century

The Organon of Medicine 6th Ed 1842 Hahnemann SC

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 103: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Homeopathy

A form of

Adaptive Network Nanomedicine

Frontiers in Bioscience Adaptive network nanomedicine an

integrated model for homeopathic medicine 20135(2)685-

708 Bell I Schwartz GE

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 104: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Homeopathy

Using Transmission Electron Microscopy (TEM) electron diffraction and chemical analysis by Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) the presence of physical entities in extreme homeopathic dilutions in the form of nanoparticles of the starting metals and their aggregates has been confirmed Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 105: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Homeopathy

Medicines in high potencies (30c and 200c) involving huge dilution factors (1060 and 10400 respectively) are many orders of magnitude greater than Avogadrorsquos number and theoretically should not contain measurable remnants of the starting materials Homeopathy 201099(4)231-242 Extreme homeopathic dilutions retain starting materials A nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

DOI 101016jhomp201005006

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 106: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Homeopathy

Observable nanoparticle forms of

source material (and silica) exist in

all homeopathic potencies

Int J High Dilution Res 201110299-310 Homeopathy

emerging as nanomedicine Upadhyay RP Nayak C

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 107: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Nanoparticles bull Measure from 1-100 nm in diameter bull Formed by

ndash Top-down milling from source material

ndash Bottom-up self-assembly

Advanced Drug Delivery Rev 201163427-40 Nanosizing for oral and parenteral drug delivery a perspective on formulating poorly-water soluble compounds using wet media milling technology Merisko-Liversidge E Liversidge GG

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 108: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Nanoparticles

Exhibit superior antioxidant properties than their respective bulk forms

J Agricult Food Chem 201260(21)5388-99 Antioxidant activities of curcumin and ascorbyl dipalmitate nanoparticles and their activities after incorporation into cellulose-based packaging films Sonkaew P Sane A Suppakul P

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 109: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Nanoparticles

More effective drug delivery vehicles

than conventional bulk form drugs

bull Reach selective targets more

efficiently

bull Reduce total dosage needed

bull Cross Blood-Brain Barrier

Current Drug Deliv 20107303-11 Nanoparticles a

promising therapeutic approach in atherosclerosis Antoniades

C Psarros C Tousoulis D et al

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 110: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Nanomedicine

Distinct advantages

bull Targets specific cells

bull Doses last longer

bull Therapeutic effects are magnified

(up to 1000 times)

Autoimmunity 200942368-72 Imaging inflammation in real

time- future of nanoparticles Hueber AJ Stevenson R Stokes

RJ et al

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 111: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Nanoparticles

Multiple selective effects

bull Apoptosis

bull Anti-inflammatory

bull Antioxidant

bull Immunomodulatory

PLoS ONE 2011 6e26684 PLGA PLGA-TMC and TMC-TPP

nanoparticles differentially modulate the outcome of nasal

vaccination by inducing tolerance or enhancing humor

immunity Keijzer C Slutter B van der Zee R et al

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 112: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Nanoparticles

bull Reduced side effects

bull Greater efficacy

bull Lower costs

Methods in Enzymology 2012508271-94 Nanotechnology

as a promising strategy for alternative routes of insulin

delivery Reis CP Damge C

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 113: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Nanoparticles

bull At high doses

ndash Trigger stronger pharmacological effects

bull At low doses

ndash Mobilize non-pharmacological biological adaptation hormesis and endogenous amplification mechanisms

Homeopathy 99 (2010) pp 231ndash242 Extreme homeopathic dilutions retain starting materials a nanoparticulate perspective Chikramane PS Suresh AK Bellare JR et al

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 114: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Nanomedicine

bull Supports the patients adaptive networks leading to functional self reorganization as a biological network

bull Host expression of a more robust cellular defense system against infections and other stressors

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative nanomedicine for improving infectious disease treatment in public health Bell IR Schwartz GE Boyer NN

DOI 101016jeujim201211002

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 115: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Homeopathy

bull The worldrsquos oldest form of

clinical nanomedicine

bull Thousands of published case

studies in worldwide database

bull Demonstrated effectiveness in a

wide range of acute and chronic

conditions

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 116: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Plasmodium infected Mice

Significant inhibitory effects on

parasite multiplication in vivo

Homeopathy 200695223-228 Effects of homeopathic

medications Eupatorium perfoliatum and Arsenicum alabum on

parasitemia of Plasmodium berghei-infected mice Lira-Salazar

G Marines-Montiel E Torres-Monzon J et al

DOI 101016jhomp200606003

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 117: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Antiviral Effects

bull In vitro

bull Human pathogenic enveloped and

non-enveloped RNA and DNA

viruses

Can J Physiol Pharmacol 2007851084-90 In vitro

evaluation of the antiviral effects of the homeopathic

preparation Gripp-Heel on selected respiratory viruses

Glatthaar-Saalmuller B

DOI 101139Y07-100

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 118: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Antiviral Effects

Significant reductions of infectivity in

ndash Human herpesvirus 1 Human adenovirus C serotype 5 Influenza A virus Human respiratory syncytial virus Human parainfluenza virus 3 Human rhinovirus B serotype 14 and Human coxsackievirus serotype A9

Can J Physiol Pharmacol 2007851084-90 In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses Glatthaar-Saalmuller B

DOI 101139Y07-100

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 119: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

HIVAIDS

bull A group of studies found specific physical immunologic neurologic metabolic and quality-of-life benefits including improvements in lymphocyte counts and functions and reductions in HIV viral loads in HIVAIDS

J Alternat Complement Med 20039133-41 Controlled clinical trials evaluating the homeopathic treatment of people with human immunodeficiency virus or acquired immune deficiency syndrome Ullman D

DOI 101089107555303321223008

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 120: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Leptospirosis

bull Homeoprophylaxis prepared from

dilutions of four circulating strains

of Leptospirosis

bull N=23 million in high risk epidemic

region

Homeopathy 201099156-66 Large-scale application of

highly-diluted bacteria for Leptospirosis epidemic control

Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 121: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Leptospirosis

bull Significant decrease of disease incidence found in intervention regions

bull Increased incidence observed in non-intervention regions

bull Intervention region incidence fell below historic median

Homeopathy 201099156-66 Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control Bracho G Varela E Fernandez R et al

DOI 101016jhomp201005009

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 122: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Disease

bull 24 month follow-up

bull N=3981

bull 97 Chronic Disease

BMC Public Health 20055115-122 Homeopathic medical

practice Long-term results of a cohort study with 3 Witt CM

Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 123: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull For adults and young children major improvements were observed for quality of life

bull Younger age and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20055115-122 Homeopathic medical practice Long-term results of a cohort study with 3 Witt CM Luumldtke R Baur R et al

DOI1011861471-2458-5-115 981 patients

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 124: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Disease

bull 8 year follow-up

bull N=3709

bull 97 Chronic Disease

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 125: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Disease

Most frequent diagnoses

ndash migraine tension type headache sleep disorders depression anxiety disorders multiple eczemas psoriasis allergic dermatitis allergic rhinitis allergies dysmenorrhea multiple infections hypertension low back pain asthma

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 126: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Chronic Disease bull Disease severity decreased

significantly (p lt 0001)

bull Physical and mental quality of life sores increased considerably

bull Younger age female gender and more severe disease at baseline were factors predictive of better therapeutic success

BMC Public Health 20088413-421 How healthy are chronically ill patients after eight years of homeopathic treatment ndash Results from a long term observational study Witt CM Luumldtke R Mengler N et al

DOI1011861471-2458-8-413

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 127: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Homeopathy and the

Microbiome

ldquoHomeopathic potencies are capable

of completely altering the bacterial

flora of the bowel and this fact has

been demonstrated in many

hundreds of casesrdquo

Br Hom J 193626163-188 The Potentised Drug and its

Action on the Bowel Flora Paterson J

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 128: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Homeopathy and Lyme

Disease

The judicious use of the classical

homeopathic method has proven

itself clinically effective in preventing

and treating illnesses like Lyme

disease in all its clinical stages

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy

and Lyme Disease Whitmont RD

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 129: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Homeopathy and Lyme

Disease

Clinical experience demonstrates that the judicious use of homeopathic medicines applied through the Classical homeopathic approach is an excellent method of treating and curing Lyme disease

J Am Inst Homeopathy 199790(4) 186-198 Homeopathy and Lyme Disease Whitmont RD

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 130: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

-Review-

Homeopathy

bull The oldest continuously utilized

form of nanomedicine worldwide

bull Effective in a wide range of

conditions including

ndash Acute infections

ndash Chronic inflammatory illness

ndash Chronic Lyme Disease

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 131: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

-Review-

Homeopathy

Advantages

ndash Ecologically sustainable

ndash Selective targeting

ndash Compatible with microbiome

ndash Ready to go

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 132: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

A Case Report of

Chronic Lyme Disease

Treated

Homeopathically

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 133: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Initial Consultation

A 92-year-old Caucasian male retired

physician presented with complaints of

ldquoChronic Lyme Diseaserdquo

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 134: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Main Symptoms

bull Multiple tick bites over previous

year

bull Living in Lyme endemic region

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 135: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Main Symptoms

bull Initial Rx Doxycycline 100mg POBID for 28 days

followed by Cefdinir 600mg POQD for an

additional 26 days

bull Initial improvement in symptoms while being

treated followed by relapse and worsening

symptoms shortly after discontinuing antibiotics

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 136: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Main Symptoms

bull Brain fog

bull Depression

bull Vertigo Worse after rising in the morning

bull Nausea with intolerance of spices and fatty foods

bull Prefers warm environments fresh air

bull ldquoClickingrdquo in neck

bull Night sweats

bull Fatigue ldquogreat effortrdquo to do deskwork Has not gone

outdoors in previous 2 months

bull Generalized Weakness with lack of energy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 137: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Medical History

bull Multiple urinary complaints including

chronic urinary retention hesitancy

incontinence nocturia

bull Recent UTI treated with Ciprofloxacin

bull Life-long history of frequent recurrent

antibiotic use (at ldquoany signrdquo of cold or

infection)

bull IBS

bull Gastroparesis

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 138: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Medical History

bull Chronic recurrent sinusitis treated

repeatedly with antibiotics

bull Hiatal hernia

bull Osteopenia

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 139: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Medical History

bull Degenerative Disc Disease (DDD)

of Spine

bull Prostate cancer sp radiation and

chemotherapy

bull Abdominal Aortic Aneurism (AAA)

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 140: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Physical Examination

bull Tall thin frail Caucasian male

bull Appeared older than stated age

bull Pectus excavatum

bull Pale skin

bull No apparent distress

bull Vital signs and physical

examination otherwise

unremarkable and noncontributory

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 141: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Diagnostic Assessment

Antibiotic overuse and abuse with evidence

of chronic dysbiosis manifesting as

bull IBS

bull Chronic sinusitis

bull Chronic LymePost Lyme Syndrome

Dysbiosis leading to chronic malabsorbtion

and malnutrition contributing to

bull Osteopenia

bull Fatigue

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 142: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Therapeutic Intervention

bull Classically Prescribed Homeopathic

Medicine 200c

bull One Single Dry Dose By Mouth

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 143: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Classical Homeopathic

Prescribing

bull Depends on the total clinical pattern of

biopsychosocial symptoms

bull Relies on

ndash Individual salience

ndash State dependency in the host to elicit

beneficial rather than adverse effects

Global Advan Health Med 20143(1)36-53 Integrative

Nanomedicine Treating Cancer with nanoscale natural products

Bell I Sarter B Koithan M et al

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 144: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

1 Month Follow-up

bull ldquoDoing much betterrdquo

bull Nausea is ldquomildrdquo worse in morning after rising

better by noon

bull Vertigo only ldquoonce in a whilerdquo usually with

nausea

bull Still Feels head isnrsquot ldquolevelrdquo not ldquoeven-keeledrdquo

bull Nocturia ldquoimprovedrdquo

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 145: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Therapeutic Intervention

bull Classically Prescribed

Homeopathic Medicine 200c

bull One Single Dry Dose By Mouth

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 146: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

3 Month Follow-up

bull ldquoVery pleased over last 6 weeksrdquo

bull Gradual improvement in energy

bull No nausea

bull No GI distension

bull No recurrent sinusitis or UTI

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 147: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

3 Month Follow-up

bull No vertigo

bull No Brain fog

bull No more urinary incontinence

bull Asks ldquoHow do you discourage old

friends from staying too longrdquo

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 148: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

1 Year Follow-up

bull No recurrence of symptoms

bull No repetition of medicine

bull Feels strong and fit

bull ldquoIrsquom doing very well for 94 I have

no complaints If I continue how I

am I will be very satisfiedrdquo

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 149: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

-Conclusion-

The Microbiome

bull An ecology

bull Directly related to Health

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 150: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

-Conclusion-

The Microbiome

Damaged by conventional

medications poor diet and overuse

of hygiene

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 151: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

-Conclusion-

The Microbiome

bull Damage results in dysbiosis

bull Dysbiosis triggers chronic

inflammation

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 152: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

-Conclusion-

Chronic Inflammatory Disease

An iatrogenic epidemic

A direct consequence of the ldquoGerm

Theoryrdquo in practice

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 153: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

-Conclusion-

Chronic Lyme Disease

A form of chronic dysbiosis

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 154: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

-Conclusion-

Homeopathy

bull A form of adaptive network

nanomedicine

bull A 200 year+ track record

bull Demonstrated superior efficacy in

treating and preventing chronic

inflammatory disease

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 155: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

-Conclusion-

Homeopathy

bull Already in use worldwide

bull A time honored methodology of

evaluation and prescription

bull Safe effective and inexpensive

when used according to

established guidelines

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 156: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

-Conclusion-

Homeopathy

In light of data from the microbiome

further investigation and use of

homeopathy is definitely warranted

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 157: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

-Conclusion-

Homeopathy

Demonstrates clinical effectiveness

in chronic Lyme disease

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 158: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

ldquoRather than rejecting the entire filed of homeopathy for its

originally vitalistic interpretations it is time for modern

scientists to examine seriously the nanomedicine

implications of Hahnemannrsquos empirical findings for

integrative health carerdquo

European Journal of Integrative Medicine 5(2)126ndash140 Advances in integrative

nanomedicine for improving infectious disease treatment in public health Bell IR

Schwartz GE Boyer NN

DOI 101016jeujim201211002

Page 159: Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome A key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Exogenous Homeopathy

skin homeopathy,hair homeopathy

Gut Microbiome and the Role in Systemic Diseaseweb.brrh.com/.../Gut-Microbiome-BOURAS/Gut-Microbiome-Bouras.pdf · Human Microbiome •Increased interest recently •Of over 5,000

Homeopathy and the Microbiome...Homeopathy and the Microbiome The key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of HomeopathyEcological

Jahr homeopathy

Logic Homeopathy

Homeopathy Cures

Scripture Homeopathy

Spagyric Homeopathy or Electro Homeopathyarticle.sciencepg.org/pdf/10.11648.j.ijhnm.20150101.11.pdfKeywords: Spagyrics, Alchemy, Spagyric Homeopathy, Electro Homeopathy, Spirituality

MICROBIOME PROBIOTICS SERIES: EUROPE · microbiome & probiotics series: europe 6th microbiome r&d & business collaboration forum 3rd probiotics congress skin microbiome & cosmeceuticals

Homeopathy Explained

Homeopathy Tarentula

Homeopathy and the Microbiome - IHS New YorkHomeopathy and the Microbiome The key to Lyme and other chronic diseases Ronald D. Whitmont, MD, President, The American Institute of Homeopathy

Scientific Homeopathy

FOR HOMEOPATHY SAVE HOMEOPATHY The FDA is proposing … · HOMEOPATHY SAVE HOMEOPATHY The FDA is proposing rules for homeopathy that could regulate it out of existence. PLEASE, go

Positive Homeopathy

Tara Homeopathy Clinic | Tara Homeopathy Clinic Reviews

Homeopathy Herbs

Homeopathy Cyclamen

ADHD & Homeopathy

Siddha, homeopathy

Workbook Homeopathy

Homeopathy Treatment

Homeopathy theories

Homeopathy & Ayurveda

Homeopathy, Healthy Medicine April 2010.pdf · Homeopathy, Healthy Medicine - April 2010 ARH Homeopathy, Healthy Medicine Sharing news, views and information about homeopathy and

Nuskhajat homeopathy

Homeopathy in Epidemics and Pandemicss presentation.pdf · Homeopathy Allopathy Allopathy. 2% 40% 60%. Homeopathy Allopathy Allopathy. 388 cases were treated with homeopathy with

Homeopathy (1)

Homeopathy 101

Classical Homeopathy

Homeopathy Graphites

Skin homeopathy,Asthma homeopathy

Homeopathy Demonstrated

Espejos Del Yo - Jung y Whitmont