MAYO SCHOOL OF CONTINUOUS PROFESSIONAL DEVELOPMENT

Friday-Saturday November 18-19, 2016

Hilton Scottsdale Resort & VillasScottsdale, Arizona

Course Co-Directors > Ramesh K. Ramanathan, M.D. and Mitesh J. Borad, M.D. – Mayo Clinic > Daniel D. Von Hoff, M.D. – Translational Genomics Research Institute (TGen); HonorHealth > Lynn Matrisian, Ph.D. – Pancreatic Cancer Action Network

$75 DISCOUNT when you register at ce.mayo.edu/node/18961 before October 21, 2016

>>Mayo Clinic Pancreatic Cancer Conference 2016

In cooperation with HEALTHHONOR TM

COURSE DESCRIPTION

This state-of-the-art conference, offered in cooperation with the Pancreatic Cancer Action Network, Translational Genomics Research Institute (TGen) and HonorHealth, is designed to provide a multidisciplinary overview regarding the molecular biology of pancreatic cancer and the importance of early diagnosis and treatment considerations, including surgery, new pharmacological agents, and how to incorporate these options into daily clinical practice. The program format will utilize case presentations, open Q&A, and an interactive keypad system to generate participant feedback and develop an optimal learning experience between faculty and course participants.

LEARNING OBJECTIVES

Upon completion of this activity, participants should be able to:

• Identify patients who will benefit from radiation therapy

• Incorporate novel agents in clinical care and clinical trial participation

• Explain palliative care management of the symptomatic patient

• Describe molecular biology of pancreatic cancer

• Describe the role of the poly ADP ribose polymerase (PARP) inhibitors and DNA damaging agents in the treatment of pancreatic cancer

• Select the appropriate regimen for first and second line therapy in treating advanced pancreatic cancer

• Describe the differences in staging between borderline and unresectable locally advanced pancreatic cancer

• Identify patients with resecetable pancreatic cancer who are candidates for a minimally invasive procedure

• Explain the role of proton therapy and potential uses in pancreatic cancer

Attendance at this Mayo Clinic course does not indicate nor guarantee competence or proficiency in the performance of any procedures which may be discussed or taught in this course.

INTENDED AUDIENCE

This course is designed for surgeons and physicians who specialize in hematology-oncology, gastroenterology, radiation-oncology, medical oncology, as well as, pain specialists, NPs, PAs, RNs, and healthcare professionals involved in cancer care. Also of interest to general internal medicine physicians who may want to enhance their oncology knowledge.

CREDIT

Mayo Clinic College of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Mayo Clinic College of Medicine designates this live activity for a maximum of 10.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

AOA: This program has been accredited by the American Osteopathic Association for 10.25 credits of AOA Category 2-A.

Other Health Care Professionals: A record of attendance will be available to other health care professionals for requesting credits in accordance with state nursing boards, specialty societies, or other professional associations.

General Information

General InformationGRANTS AND EXHIBITS

At the time of this printing, a complete listing of commercial supporters (financial or in-kind) was not available. Appropriate acknowledgment will be given to all supporters at the time of the meeting. Exhibits will be available for viewing at all scheduled breaks.

DATE AND LOCATION

The Mayo Clinic Pancreatic Cancer Conference will be held November 18-19, 2016 at the Hilton Scottsdale Resort & Villas, 6333 N. Scottsdale Road, Scottsdale, AZ 85250

REGISTRATION

Visit https://ce.mayo.edu/node/18961 to register online. The registration fee includes tuition, comprehensive course syllabus (electronic) continental breakfasts, break refreshments, and a welcome reception on Friday evening. Although it is not Mayo School of Continuous Professional Development (CPD) policy to limit the number of registrants for a course, conference room facilities may necessitate closing of enrollment; therefore, early registration is advised. A confirmation is provided upon receipt of payment. Please present the confirmation letter when checking in at the meeting registration desk.

REGISTRATION FEE(S)

FOR ADDITIONAL INFORMATION, CONTACT

Mayo School of Continuous Professional Development 13400 East Shea Boulevard Scottsdale, Arizona 85259 Website: ce.mayo.edu/node/18961 E-mail: mca.cme@mayo.edu (480) 301-4580

CANCELLATION POLICY

If you cancel your participation in this course, your registration fee, less a $75 administrative fee, will be refunded when written notification is received by Mayo School of CPD before November 4, 2016 (mca.cme@mayo.edu). No refunds will be made on or after November 4, 2016. Canceled registrations are non-transferable.

Mayo School of CPD reserves the right to cancel or postpone any course due to unforeseen circumstances. In the unlikely event Mayo School of CPD must cancel or postpone this course, Mayo School of CPD will refund the registration fee, but is not responsible for any related costs, charges, or expenses to participants, including fees assessed by airline/travel/lodging agencies.

Medical Professional Type

On or Before October 21, 2016

After October 21, 2016

Fee, U.S. Dollars $

Physicians/Scientists 305.00 380.00

Residents, Physician Assistants, Nurse Practitioners, Others

230.00 305.00

Welcome Reception Included in registration fee for attendee and one guest

NATIONAL PHYSICIAN PAYMENT TRANSPARENCY PROGRAM

Mayo Clinic College of Medicine complies with the requirements of the National Physician Payment Transparency Program OPEN PAYMENTS (Physician Payments Sunshine Act).

TRANSPORTATION

Hertz is offering a reduced daily rate for course registrants. Visit Hertz online at http://tinyurl.com/Mayo-ClinicHertz (CV: 03NR0011). Special rates include unlimited mileage and are subject to availability. Advance reservations are recommended; blackout dates may apply.

SuperShuttle vans offer airport transportation to and from area hotels and businesses. To make reservations, call (800) 258-3826 or (602) 244-9000, or visit www.supershuttle.com

RECREATION/LEISURE ACTIVITIES

Visit www.visitphoenix.com or www.experiencescottsdale.com

LODGING ACCOMMODATIONS

Hilton Scottsdale Resort & Villas 6333 North Scottsdale Road s Scottsdale, AZ 85250 (800) 498-7396 or (480) 948-7750 s www.ScottsdaleResort.hilton.com

Located in the heart of Scottsdale, the Hilton Scottsdale Resort & Villas is within minutes of shopping, dining, world-class golf, and upscale business districts. Set in the shadow of the majestic Camelback Mountain, this AAA Four Diamond Scottsdale resort combines a relaxed ambience with decor inspired by the Sonoran Desert.

A block of guest rooms have been reserved for attendees and their guests for the Mayo Clinic Pancreatic Cancer Conference attendees at the special course rate of $149 per night (single/double/triple/quad occupancy), plus tax. Guest parking is complimentary. In order to receive the special rate, reservations must be made before the room block is filled and before the expiration date of October 27, 2016.

Please call (800) 498-7396 and identify yourself as a participant of the Mayo Clinic Pancreatic Cancer Conference when making your reservation or reserve your room online at http://tinyurl.com/2016PANCAN

Attendees are responsible for their own reservations. The standard hotel reservation cancellation policy will apply to individual reservations unless otherwise specified.

Mayo School of CPD is not responsible for expenses incurred by an individual who is not confirmed and for whom space is not available at the meeting. Costs incurred by the registrant such as airline or hotel fees or penalties are the responsibility of the registrant.

General Information

FACULTY

Course Co-Directors Ramesh K. Ramanathan, M.D. – Mayo Clinic Mitesh J. Borad, M.D. – Mayo Clinic Lynn M. Matrisian, Ph.D., M.B.A. – The Pancreatic Cancer Action Network Daniel D. Von Hoff, M.D., F.A.C.P. – Translational Genomics Research Institute

Mayo Clinic Faculty Jonathan B. Ashman, M.D., Ph.D. Michael T. Barrett, Ph.D. Tom R. Fitch, M.D. Michael L. Kendrick, M.D. Amit K. Mathur, M.D. Robert R. McWilliams, M.D. Christine O. Menias, M.D. Kabir Mody, M.D. Adyr A. Moss, M.D. Muhammad Murtaza, M.B.B.S., Ph.D. Rahul Pannala, M.D. Tanios S. Bekaii-Saab, M.D.

Guest Faculty Erkut Borazanci, M.D. – HonorHealth - Scottsdale, AZ Ananya Das, M.D. – St. Joseph’s Hospital – Phoenix, AZ E. Gabriela Chiorean, M.D. – Seattle Cancer Care Alliance – Seattle, WA Douglas B. Evans, M.D., F.A.C.S. – Medical College of Wisonsin – Milwaukee, WI Karyn A. Goodman, M.D. – University of Colorado Cancer Center – Aurora, CO Manuel Hidalgo, M.D., Ph.D. – Beth Israel, Harvard – Boston, MA Gayle S. Jameson, C.R.N.P. – Translational Genomics Research Institute Toufic Kachaamy, M.D. – Cancer Treatment Centers of America – Goodyear, AZ Andrew Ko, M.D. – University of California-San Francisco – San Francisco, CA Ronald S. Korn, M.D., Ph.D. – Scottsdale Medical Imaging – Scottsdale, AZ Kenneth P. Olive, Ph.D. – Columbia University Medical Center – New York, NY Vincent J. Picozzi, Jr., M.D. – Virginia Mason Medical Center – Seattle, WA Gauri R. Varadhachary, M.D. – MD Anderson – Houston, TX

SOCIAL PROGRAM

Welcome Reception – Friday, November 18, 2016 – 6:00-8:00 p.m. Attendees are cordially invited to join the course faculty for the Welcome Reception. This casual reception welcomes you to Scottsdale, officially opens the course, and offers you the perfect opportunity to make connections with existing and new colleagues. Registrant and one guest are included in registration fee. Pre-registration is required.

PROGRAM AT-A-GLANCE

A comprehensive program with times and faculty noted can be found on the course website at https://ce.mayo.edu/node/18961. Program subject to change.

General Information

Faculty Disclosure: As a provider accredited by ACCME, Mayo Clinic College of Medicine (Mayo School of Continuous Professional Development) must ensure balance, independence, objectivity and scientific rigor in its educational activities. Course director(s), planning committee, faculty, and all others who are in a position to control the content of this educational activity are required to disclose all relevant financial relationships with any commercial interest related to the subject matter of the educational activity. Safeguards against commercial bias have been put in place. Faculty also will disclose any off-label and/or investigational use of pharmaceuticals or instruments discussed in their presentation. Disclosure of this information will be published in the course materials so those participants in the activity may formulate their own judgments regarding the presentation.

ProgramFriday, November 18

12:00 p.m. Registration

12:45 Welcome and Introduction Mitesh J. Borad, M.D. and Ramesh K. Ramanathan, M.D.

Session I: Current Understanding of Pancreatic Cancer

Moderator: Muhammad Murtaza, M.B.B.S., Ph.D.

1:00 Translation of Preclinical Models into the Clinic Kenneth P. Olive, Ph.D.

1:25 Mechanisms of Tumor Response and Resistance Michael T. Barrett, Ph.D.

1:50 Precision Medicine for Pancreatic Cancer: Pancreatic Cancer Action Network Experience Lynn M. Matrisian Ph.D., M.B.A.

Moderator: Lynn Matrisian, Ph.D., M.B.A.

2:10 Molecular Tumor Board and Case Discussion Panel: Ramesh K. Ramanathan, M.D., Mitesh J. Borad, M.D. and Tanios S. Bekaii-Saab, M.D.

2:35 Refreshment Break

Session II: Diagnostic Dilemmas Moderator: Mitesh J. Borad, M.D.

3:00 Imaging and Staging for Pancreatic Cancer Christine O. Menias, M.D.

3:20 Mucinous Neoplasms and Cysts Rahul Pannala, M.D.

3:40 Case Discussion 1 Toufic Kachaamy, M.D.

4:05 Case Discussion 2 Ananya Das, M.D.

4:30 Panel and Case Discussion Ananya Das, M.D., Toufic Kachaamy, M.D., Christine O. Menias, M.D. and Rahul Pannala, M.D.

4:55 Brief Intermission

Introduction: Daniel D. Von Hoff, M.D., F.A.C.P.

5:05 Key Note Address: Manuel Hidlago, M.D., Ph.D.

5:50 Adjourn

6:00-8:00 Welcome Reception (Opportunity for Networking)

Saturday, November 19

8:00 a.m. Continental Breakfast

Session III: Treatment Considerations for Resectable Pancreatic Cancer Moderator: Adyr A. Moss, M.D.

8:30 Minimally Invasive Surgery Michael L. Kendrick, M.D.

8:55 Adjuvant Therapy Andrew Ko, M.D.

9:20 Radiation Techniques in the Adjuvant Setting Jonathan B. Ashman, M.D., Ph.D.

9:45 Case Report and Panel Discussion Jonathan B. Ashman, M.D., Ph.D., Michael L. Kendrick, M.D. and Andrew Ko, M.D.

10:00 Refreshment Break

Saturday, November 19 (continued)

Session IV: Borderline/Locally Advanced Disease Moderator: Amit K. Mathur, M.D.

10:30 Surgery Douglas B. Evans, M.D., F.A.C.S.

10:55 Preoperative Chemotherapy Gauri R. Varadhachary, M.D.

11:20 Radiation Techniques Karyn A. Goodman, M.D.

11:45 Case Report and Panel Discussion Douglas B. Evans, M.D., F.A.C.S., Karyn A. Goodman, M.D. and Gauri R. Varadhachary, M.D.

Breakout Sessions Instructions

12:00 p.m. Lunch

Session V: Breakout Sessions (Choose A or B) Moderator: Kabir Mody, M.D.

Breakout Session A: Supportive Care

1:00 Cachexia/Nutrition Gayle S. Jameson, C.R.N.P.

1:25 Supportive Care Tom R. Fitch, M.D.

1:50 Integrative Medicine Gayle S. Jameson, C.R.N.P.

2:15 Q&A Panel

2:30 Refreshment Break

Breakout Session B: Clinical Trials Corner

1:00 Use of PET Ronald S. Korn, M.D., Ph.D.

1:20 Topic 1 Robert R. McWilliams, M.D.

1:40 Topic 2 Erkut Borazanci, M.D.

2:00 Topic 3 Mitesh J. Borad, M.D.

2:20 Q&A Panel

2:30 Refreshment Break

Session VI: Treatment of Advanced Disease Moderator: Ramesh K. Ramanathan, M.D.

3:00 First Line Tanios S. Bekaii-Saab, M.D.

3:25 Second Line and Beyond Vincent J. Picozzi, Jr., M.D.

3:50 Targeting Molecular Subsets E. Gabriela Chiorean, M.D.

4:15 Wrap Up Ramesh K. Ramanathan, M.D. and Daniel D. Von Hoff, M.D., F.A.C.P.

4:30 Adjourn

(Program is subject to change.)

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