hormones chemical substances - produced by endocrine glands - secreted into the blood - circulate...
TRANSCRIPT
Hormones
Chemical substances
- produced by endocrine glands
- secreted into the blood
- circulate throughout the entire body.
- target tissues respond to hormones.
Target tissues
Hormones you are responsible for:
Sex Hormones – Produced by the gonads:Androgens: Testosterone, Androstenedione,
DHT, Androstenediol
Estrogens: Estradiol, Estrone
Progesterone
Gonadotropins – Produced by the pituitary:Luteninizing Hormone (LH)Follicle Stimulating Hormone (FSH)
Gonadotropin Releasing Hormone (GnRH) – Produced by the hypothalamus
Steroid Biosynthetic Pathway
Pregnenolone
Progesterone 17-OH Pro..Androsteno-
dioneTestosterone
Androsteno-diolDehydro…17-Preg….
Cortiso…lCorticosterone
EstradiolEstrone11-Deoxy..Deoxy….
Aldosterone
17-OH Cort
Cholesterol
21-OH
11-OH
Aromatase Aromatase21-OH
11-OH
3B-HSO 3B-HSO 3B-HSO 3B-HSO
CYP-17
CYP-17
CYP-17
Lyase
Lyase
17B-HSO
17B-HSO
What you need to know about the Steroid Biosynthetic Pathway
1.Cholesterol is the precursor to the all of the steroids.
2.Masculinizing and Feminizing hormones utilize the same biosynthetic pathway. No step in the pathway can be skipped.
3.Masculinizing and Feminizing hormones are very similar in size and chemical composition.
4.The main difference is that estrogens have aromatic rings.
Testosterone
Testosterone at Puberty
Estrogen at Puberty
Negative Feedback System
Testes
(Interstitial Cells Produce Testosterone)
LH Testosterone
Hypothalamus - Thermostat
Pituitary Gland – Produces LH
Negative Feedback System Testes
(Sertoli cells regulate sperm production)
FSH Sperm
Hypothalamus - Thermostat
Pituitary Gland – Produces FSH
Ejaculation
Negative Feedback System Testes
(Sertoli cells produce Inhibin)
Stops FSH
Inhibin – No sperm produced
Hypothalamus - Thermostat
Pituitary Gland – Produces FSH