Dr. Roisin Adams

Mar 2015

National Centre for Pharmacoeconomics

Pharmacoeconomics

Methods and Practical

Applications

The NCPE conducts the health

technology assessment (HTA) of

pharmaceutical products for the Health

Service Executive

Challenges

Benefit

Small studies

Single arm (no comparison)

Adverse Events

Uncertainty

In relation to lifetime extrapolations

How a drug may be used in Ireland

Costs

Justification

Additional hidden costs

Cathal

How is the patient voice heard currently

Formally

QALY valuations

Preferences for health measured by society

Informally

Organisations incl. IPPOSI,

Patient groups

Political debate and election

The QALY

Measures changes in length of life and

HRQoL

Length of life measured in natural units

(years)

QALY = Length of life x Utility

QALY Valuations

We ask people to make their preferences

in relation to health

Asking a person to state their preference

(choose) for one option (health state) over

another

E.g. Life A or Life B or Length of time in Life

A or Life B

Hypothetical versus Experienced

Most country valuations have valued

hypothetical health states

Vs.

Irish Valuation

Measure Health

Value

VAS (Thermometer measure)

Rank health states (from best to worst)

Time Trade Off

VAS

Ranking

EQ-5D

Please complete the questionnaire