http://. bacteria that cause the disease. discovery ◦ pacini- 1854 ◦ koch- 1883

http://www.oddee.com/item_90608.aspx

Bacteria that cause the disease.

Discovery◦ Pacini- 1854◦ Koch- 1883

http://en.wikipedia.org/wiki/Cholera

Vector◦ Marine Life

◦ Shellfish◦ Oysters

◦ Zooplankton

http://www.britannica.com/EBchecked/topic/114078/cholera#

•Pass through stomach•Activated in small intestine

http://www.biocrawler.com/w/images/f/f6/Vibrio_cholerae.jpg

•Pass through stomach•Activated in small intestine•Flagella production•Mucus layer


•Pass through stomach•Activated in small intestine•Flagella production•Mucus layer•Epithelial cell surface•Produce: Cholera Toxin


Sodium: Na+

◦ 20-30g

Sodium: Na+

◦ 20-30g SGLT1 Proteins

◦ Na+

◦ Glucose

Section A enters Stimulation Pathway

Germann, William J., Cindy L. Stanfield. Principles of Human Physiology. 2nd ed. San Francisco: Pearson, 2005

Section A enters Stimulation Pathway Cl- flowing out Na+ follows it H20 follows them


Section A enters Stimulation Pathway Cl- flowing out Na+ follows H20 follows them Na+ /glucose

uptake can’t keep up.


Extremely watery diarrhea: “rice-water” stool

http://smartabouthealth.net/diseases/2009/03/10/cholera-deaths-in-zimbabwe-tops-4000/

Extremely watery diarrhea: “rice-water” stool Vomiting

Dehydration Extreme thirst ** Low urine output Lack of tears


Extremely watery diarrhea: “rice-water” stool Vomiting

Dehydration Extreme thirst ** Low urine output Lack of tears

Hypovolemic shock

Death


Mode of transmission◦ Fecal to oral

Mode of transmission◦ Fecal to oral

DiarrheaIs this the body’s

evolved defense mechanism?

Or cholera’s evolved infection method?

3rd world predominantly Drinking water

No filtering No processing No purifying

Lack knowledge◦ Children

Little to no water Infrastructure

http://www.britannica.com/EBchecked/topic/114078/cholera#http://en.wikipedia.org/wiki/Cholera

http://www.phac-aspc.gc.ca/tmp-pmv/info/cholera-eng.php

Oral Rehydration therapy (ORT):◦ Oral rehydration salts◦ H2O◦ Intravenous rehydration

Public health is the main way (right now)◦ Water infrastructure

Clean drinking water Sanitation Hygiene

Education

Vaccine

http://fieldnotes.unicefusa.org/photos/

www.wikipedia.org◦ Cholera, Vibrio Cholerae, Cholera Toxin, Zooplankton, Small Intestine, SGLT1 Protein,

Enterotoxin, ORT, Cholera Toxin Pathway:

◦ Germann, William J., Cindy L. Stanfield. Principles of Human Physiology. 2nd ed. San Francisco: Pearson, 2005

Effects on Heatlh◦ https://health.google.com/health/ref/Cholera

As Usual:◦ Weekly epidemiological report- 4 AUGUST 2006, 81st YEAR

http://www.who.int/wer/2006/wer8131.pdf◦ http://www.britannica.com/EBchecked/topic/114078/cholera#

Incidence Reports◦ http://www.who.int/topics/cholera/surveillance/en/index.html

Treatment◦ WHO/CDS/CSR/ISR/2000.1 WHO Report on Global Surveillance of Epidemic-prone Infectious

Diseases- http://www.who.int/csr/resources/publications/surveillance/en/cholera.pdf

http://. bacteria that cause the disease. discovery ◦ pacini- 1854 ◦ koch- 1883

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