Mesenchymal aTGF Snail Zeb1

BMP1 3.12 - -

BMP7 - 10.88 4.90

COL3A1 11.12 45.86 6.05

GNG11 - 6.05 -

MAP1B - - 3.29

NODAL - - 3.36

SNAI3 - 5.18 14.79

SPARC 14.68 11.79 5.95

TWIST1 8.47 5.29 3.58

WNT5B 6.61 11.56 3.99

Epithelial aTGF Snail Zeb1

FGFBP1 - -4.28 -3.35

KRT14 - - -3.15

Supplemental Table 1: Differentially regulated genes in H358 models after induction of aTGF, Snail and Zeb1 in vivo.

aTGF Snail Zeb1

BMP7 - - -

FGFBP1 - -3.01 -

NODAL - - -

SNAI3 - - -

Human-Mouse Cross Reactive Human Specific

Downregulated Upregulated

Supplemental Figure 1:

Snail in vivo

aTGF in vivo

Zeb1 in vivo

Supplemental Figure 1: