hypothalamus & pituitary gland 3.2

7/26/2019 Hypothalamus & Pituitary Gland 3.2

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HYPOTHALAMUS &

PITUITARY GLAND



LOCATION (ANATOMICAL POSISITON)



HYPOTHALAMUS (HPT)

• Hypothalamus meupa!a" #a$%a" a% %e"'ephalo"

• atas a"te%o (ostal) 'h%asma opt%'um* lam%"atem%"al%s* 'om%ssua a"t

– Supe%o thalamus

– I"+e%o h%po,s%s

– Post ('aual) teme"tum me'e"'ephalo"

– Latetla 'apsula %"te"a

• -u"$s% sa"$at pe"t%"$ #a$% tu#uh u"tu! !elesta%a"

%% a" !elesta%a" spes%es. – Me"$o"tol s%stem saa+ auto"om

– Me"$o"tol s%stem e"o!%"

– Me"$o"tol homeostat%s



Nuclei hyphothalamus

o/yto'%"

ADH



TH0 0NDOCRIN0 -UNCTION O- HPT

Penghasil hormon

• D%se#ut "euose'etoy'ell u1u"$2u1u"$ a!so"me"$has%l!a" homo"(#u!a" "ueota"sm%tte)

• Te%% a% – Nu'3 supaopt%'us

4asopess%" (ADH)

– Nu'3 Paa5e"t%'ula%s(NP4) O/yto'%"

• A!so""ya #ea!h% %p%tu%tay post("euohypophys%s)

kontrol sekresihormon

• Me"$o"tol $la"3 P%tutay& $la"3 P%"eal

• Se!es% Real%s%"$ -a'to(R-) & I"h%#%t%"$ -a'to (I-)

• Nu'3 A'uatus*Nu'3supa'h%asmat%'us*NP4* Nu'3 Dosome%al*

Nu'3 Peopt%'us* Nu'3A"te%o

• A!so""ya#ea!h% %em%"et%a me%a"a



HypophysealPortal System(HPS)

• D%#e"tu! oleh

• a3 hypophyseal%s supe%o('a#a"$ a3 Caot%s I"te"a)

• Ple/us p%me HPS

• 4e"a pota hypophys%al%s

• 4as'ula s%"oso% (Ple/us

se!u"e HPS)

• A3 hypophyseal%s supe%o me"u1u!e em%"e"t%a me%a"a a"

#e'a#"$6 me"1a% !ap%le (ple/usp%me)

• 7ap%le aa y$ pa"1a"$ aa y$

pe"e! tuu" me"u1u lo#usa"te%o p%tu%tay a" me"1a%

s%"oso%2s%"oso% (ple/us se!u"e)

• U1u"$ a!so" me"se!es%!a" R- a"

I- !e !ap% % em%"et%a me%a"a



Gland. Pituitary(Hypophysis)

• The p%tu%tay $la"

a pea2shape

• D%amete 8983: 'm

• Teleta! paa +ossahypophys%al%s paa sellatu'%'a os3 Sphe"o%

• Me"empel paahypotalamaus melalu% suatuta"$!a% (%"+u"%#ulum)

• Dapat %#a$% me"1a% 6#a$%a" se'aa a"atom%s*

em#yolo$%s* a" ,s%olo$%s• P%tutay a"t

(ae"ohypophys%s)

• P%tu%tay post("euohypophys%s)



Gla"3 P%tu%tay

Lobus anterior

• D%se#utae"ohypophys%s

• ;:< total #eat

• P o$ e=asa te%%a% 6 – Pas %stal%s (#a$%a" y$

#esa) – Pas tu#eal%s ( sau"$

ya"$ me"$el%l%"$%%"+u"%#ulum)

Lobus posterior

• D%se#ut "euhypophys%s

• 6:< #eat

• Te%% a% 6 #a$%a" – pars nervosa, the larger

bulbar portion, and

– the inundibulum.

!atatan" Aa #a$%a" !et%$a a%p%tu%tay ya"$ %se#ut lo#us%"teme%us

• Lo#us %%"% #ehe"t%#e!em#a"$ paa masa +etal

• tetap% se#a$%a" sel"ya



P%tu%tay A"te%o



Pituitary !ontrol



A/%s Hypotalamo2p%tu%tay 'o"tol



#$N%&$L G&$'%H H$&$N



insulinlike groth actors (*G+s)or somatomedins

• Paa a"a! a" ema1a Petum#uha"a" pol%+eas% sel tula"$ a" otot

• Paa o$ e=asa Memel%haa masaotot a" tula"$* Pe"yem#uha" lu!aa" pe#a%!a" 1a%"$a"

• Me"uu"!a" upta!e $lu!osa oleh sel

(otot a" hepa)



PITUITARY POST0RIOR

• ADH (4ASSOPR0SSIN)

• O>YTOCIN – o/yto'%" a?e'ts t=o ta$et

t%ssues the mothe@s

uteus a" #easts – Du%"$ el%5ey* o/yto'%"

e"ha"'es 'o"ta't%o" o+smooth mus'le 'ells %" the=all o+ the uteus.

– a+te el%5ey myoeph%tel%al 'ells'o"ta't%o" o+ mamay$la" m%l! e1e't%o"



Ae"al Gla"



Lap%sa"2lap%sa" Gla"ulaAe"al



M%"ealo!ot%!o%(Alosteo")



GL#$#$&%*#$*-• Cot%sol* 'ot%'osteol* a"

'ot%so"

• 0+e! $lu!o!ot%!o%

1. Protein breakdown

2. Glucose formation

3. Lipolysis

4. Resistance to stress

5. Antiin!ammatorye"ects

#. $epression of immuneresponses

• Ne$at%5e +ee#a'!e$ulat%o" o+ $lu'o'ot%'o%se'et%o"



• ANDROG0N ONA R0TICULARIS – D%se!es%!a" paa p%a a" =a"%ta

– Dehyoep%a"osteo"e (DH0A)

•

M0DULLA ADR0NAL – a mo%,e sympathet%' $a"$l%o" o+ the auto"om%'

"e5ous system (ANS)

– The homo"e2pou'%"$ 'ells* 'alle chromancells

– These 'ells ae %""e5ate #y sympathet%'pe$a"$l%o"%' "euo"s o+ the ANS

– Homo" epinephrine and norepinephrine (N/)



Summay o+ Ae"al Gla" Homo"



Gla"ula P%"eal%s

• Meupa!a" #a$%a" a% ep%thalamus telet!a paa atap 4e"t%!el tet%us

• Sel"ya %se#ut p%"ealo'ytes

•Me"$has%l!a" homo" melato"%

• -u"$s% contribute to t%e settin& of t%ebody's biolo&ical clock

• D%!o"tol oleh "u'3 Supa'h%asmat%'us HPT

• Ra"$sa"$ $elap et%"a "u'3SC Ga"$l%o" 'e5%'al%s supe%o p%"ealo'ytes melato"% t%u



THYMUS

• Lo'ate #eh%" the ste"um #et=ee"the lu"$s

• hymosin, thymic humoral actor(%H+), thymic actor (%+), andthymopoietin

• - (>) pomote the matuat%o" o+ T

'ells a" may eta the a$%"$po'ess



0ICOSANOID

hypothalamus & pituitary gland 3.2

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