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  • 8/10/2019 IARC Classification

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    1

    Agents Classif ied by the IARC Monographs, Volumes 1111

    CAS No Agent Group Volume Year

    026148-68-5 A-alpha-C (2-Amino-9H-pyrido[2,3-b]indole) 2B 40, Sup 7 1987

    000083-32-9 Acenaphthene 3 92 2010

    025732-74-5 Acepyrene (3,4-dihydrocyclopenta[cd]pyrene) 3 92 2010

    000075-07-0 Acetaldehyde 2B 36, Sup 7, 71 1999

    000075-07-0 Acetaldehyde associated with consumption of alcoholicbeverages

    1 100E 2012

    000060-35-5 Acetamide 2B 7, Sup 7, 71 1999

    000103-90-2 Acetaminophen (see Paracetamol)

    Acheson process, occupational exposure associated with 1 111 In prep

    059277-89-3 Aciclovir 3 76 2000

    Acid mists, strong inorganic 1 54, 100F 2012

    000494-38-2 Acridine orange 3 16, Sup 7 1987

    008018-07-3 Acriflavinium chloride 3 13, Sup 7 1987

    000107-02-8 Acrolein 3 63, Sup 7 1995

    000079-06-1 Acrylamide(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 60, Sup 7 1994

    000079-10-7 Acrylic acid 3 19, Sup 7, 71 1999

    Acrylic fibres 3 19, Sup 7 1987

    000107-13-1 Acrylonitrile 2B 71 1999

    Acrylonitrile-butadiene-styrene copolymers 3 19, Sup 7 1987

    000050-76-0 Actinomycin D 3 10, Sup 7 1987023214-92-8 Adriamycin

    (NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 10, Sup 7 1987

    003688-53-7 AF-2 [2-(2-Furyl)-3-(5-nitro-2-furyl)acrylamide] 2B 31, Sup 7 1987

    001402-68-2 Aflatoxins 1 56, 82, 100F,Sup 7

    2012

    006795-23-9 Aflatoxin M1 2B 56 1993

    002757-90-6 Agaritine 3 31, Sup 7 1987

    Alcoholic beverages 1 44, 96, 100E 2012

    000116-06-3 Aldicarb 3 53 1991

    000309-00-2 Aldrin 3 5, Sup 7 1987

    Aloe vera, whole leaf extract 2B 108 in prep

    000107-05-1 Allyl chloride 3 36, Sup 7, 71 1999

    000057-06-7 Allyl isothiocyanate 3 73, Sup 7 1999

    002835-39-4 Allyl isovalerate 3 36, Sup 7, 71 1999

    Alpha particles (see Radionuclides)

    Aluminium production 1 34, Sup 7,92, 100F

    2012

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    Agents Classif ied by the IARC Monographs, Volumes 1111

    CAS No Agent Group Volume Year

    000915-67-3 Amaranth 3 8, Sup 7 1987

    004657-93-6 5-Aminoacenaphthene 3 16, Sup 7 1987

    000117-79-3 2-Aminoanthraquinone 3 27, Sup 7 1987

    000060-09-3 para-Aminoazobenzene 2B 8, Sup 7 1987

    000097-56-3 ortho-Aminoazotoluene 2B 8, Sup 7 1987

    000150-13-0 para-Aminobenzoic acid 3 16, Sup 7 1987

    000092-67-1 4-Aminobiphenyl 1 1, Sup 7, 99,100F

    2012

    000081-49-2 1-Amino-2,4-dibromoanthraquinone 2B 101 2013

    000082-28-0 1-Amino-2-methylanthraquinone 3 27, Sup 7 1987

    000712-68-5 2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole 2B 7, Sup 7 1987

    000099-57-0 2-Amino-4-nitrophenol 3 57 1993

    000121-88-0 2-Amino-5-nitrophenol 3 57 1993

    000119-34-6 4-Amino-2-nitrophenol 3 16, Sup 7 1987

    000121-66-4 2-Amino-5-nitrothiazole 3 31, Sup 7 1987

    002432-99-7 11-Aminoundecanoic acid 3 39, Sup 7 1987

    000061-82-5 Amitrole(NB: Overall evaluation downgraded to Group 3 withsupporting evidence from other relevant data)

    3 79, Sup 7 2001

    000069-53-4 Ampicillin 3 50 1990

    051264-14-3 Amsacrine 2B 76 2000

    Androgenic (anabolic) steroids 2A Sup 7 1987Anaesthetics, volatile 3 11, Sup 7 1987

    000523-50-2 Angelicin plus ultraviolet A radiation 3 40, Sup 7 1987

    000062-53-3 Aniline 3 27, Sup 7 1987

    000090-04-0 ortho-Anisidine 2B Sup 7, 73 1999

    000104-94-9 para-Anisidine 3 27, Sup 7 1987

    000191-26-4 Anthanthrene 3 92, Sup 7 2010

    000120-12-7 Anthracene 3 92, Sup 7 2010

    000118-92-3 Anthranilic acid 3 16, Sup 7 1987

    000084-65-1 Anthraquinone 2B 101 2013

    001309-64-4 Antimony trioxide 2B 47 1989001345-04-6 Antimony trisulfide 3 47 1989

    000052-46-0 Apholate 3 9, Sup 7 1987

    024938-64-5 para-Aramid fibrils 3 68 1997

    000140-57-8 Aramite 2B 5, Sup 7 1987

    Areca nut 1 85, 100E 2012

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    Agents Classif ied by the IARC Monographs, Volumes 1111

    CAS No Agent Group Volume Year

    000313-67-7 Aristolochic acid(NB: Overall evaluation upgraded to Group 1 based onmechanistic and other relevant data)

    1 82, 100A 2012

    000313-67-7 Aristolochic acid, plants containing 1 82, 100A 2012

    007440-38-2 Arsenic and inorganic arsenic compounds 1 23, Sup 7,100C

    2012

    064436-13-1 Arsenobetaine and other organic arsenic compounds thatare not metabolized in humans

    3 100C 2012

    Art glass, glass containers and pressed ware(manufacture of)

    2A 58 1993

    001332-21-4

    013768-00-8

    012172-73-5

    017068-78-9

    012001-29-5

    012001-28-4

    014567-73-8

    Asbestos (all forms, including actinolite, amosite,anthophyllite, chrysotile, crocidolite, tremolite)

    (NB: Mineral substances (e.g. talc or vermiculite) thatcontain asbestos should also be regarded ascarcinogenic to humans.)

    1 14, Sup 7,100C

    2012

    001912-24-9 Atrazine(NB: Overall evaluation downgraded to Group 3 withsupporting evidence from other relevant data)

    3 53, 73 1999

    012174-11-7 Attapulgite (see Palygorskite)

    000492-80-8 Auramine 2B 1, Sup 7, 99,100F

    2012

    Auramine production 1 Sup 7, 99,100F

    2012

    012192-57-3 Aurothioglucose 3 13, Sup 7 1987

    000320-67-2 Azacitidine(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 50 1990

    000115-02-6 Azaserine 2B 10, Sup 7 1987

    000446-86-6 Azathioprine 1 26, Sup 7,100A

    2012

    000151-56-4 Aziridine(NB: Overall evaluation upgraded to Group 2B with

    supporting evidence from other relevant data)

    2B 9, Sup 7, 71 1999

    001072-52-2 2-(1-Aziridinyl)ethanol 3 9, Sup 7 1987

    000800-24-8 Aziridyl benzoquinone 3 9, Sup 7 1987

    000103-33-3 Azobenzene 3 8, Sup 7 1987

    000202-94-8 11H-Benz[bc]aceanthrylene 3 92 2010

    000202-33-5 Benz[j]aceanthrylene(NB: Overall evaluation upgraded to Group 2B withsupporting mechanistic and other relevant data)

    2B 92 2010

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    Agents Classif ied by the IARC Monographs, Volumes 1111

    CAS No Agent Group Volume Year

    000211-91-6 Benz[l]aceanthrylene 3 92 2010

    000225-11-6 Benz[a]acridine 3 32, Sup 7,103

    2013

    000225-51-4 Benz[c]acridine 3 32, Sup 7,103

    2013

    000056-55-3 Benz[a]anthracene 2B 92, Sup 7 2010

    000071-43-2 Benzene 1 29, Sup 7.100F

    2012

    000092-87-5 Benzidine 1 29, Sup 7,99, 100F

    2012

    Benzidine, dyes metabolized to(NB: Overall evaluation upgraded to Group 1 based on

    mechanistic and other relevant data)

    1 99, 100F 2012

    000214-17-5 Benzo[b]chrysene 3 92 2010

    000196-78-1 Benzo[g]chrysene 3 92 2010

    000203-33-8 Benzo[a]fluoranthene 3 92, Sup 7 2010

    000205-99-2 Benzo[b]fluoranthene 2B 92 2010

    000203-12-3 Benzo[ghi]fluoranthene 3 92, Sup 7 2010

    000205-82-3 Benzo[j]fluoranthene 2B 92 2010

    000207-08-9 Benzo[k]fluoranthene 2B 92 2010

    000238-84-6 Benzo[a]fluorene 3 92, Sup 7 2010

    000243-17-4 Benzo[b]fluorene 3 92, Sup 7 2010

    000205-12-9 Benzo[c]fluorene 3 92, Sup 7 2010

    000271-89-6 Benzofuran 2B 63 1995

    000239-35-0 Benzo[b]naphtho[2,1-d]thiophene 3 103 2013

    000191-24-2 Benzo[ghi]perylene 3 92, Sup 7 2010

    000195-19-7 Benzo[c]phenanthrene(NB: Overall evaluation upgraded to Group 2B withsupporting evidence from other relevant data)

    2B 92, Sup 7 2010

    000119-61-9 Benzophenone 2B 101 2013

    000050-32-8 Benzo[a]pyrene(NB: Overall evaluation upgraded to Group 1 based onmechanistic and other relevant data)

    1 Sup 7, 92,100F

    2012

    000192-97-2 Benzo[e]pyrene 3 92, Sup 7 2010

    000105-11-3 para-Benzoquinone dioxime 3 29, Sup 7, 71 1999

    000094-36-0 Benzoyl peroxide 3 36, Sup 7, 71 1999

    000140-11-4 Benzyl acetate 3 40, Sup 7, 71 1999

    001694-09-3 Benzyl violet 4B 2B 16, Sup 7 1987

    007440-41-7 Beryllium and beryllium compounds 1 Sup 7, 58,100C

    2012

    Beta particles (see Radionuclides)

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    Agents Classif ied by the IARC Monographs, Volumes 1111

    CAS No Agent Group Volume Year

    Betel quid with tobacco 1 Sup 7, 85,100E

    2012

    Betel quid without tobacco 1 Sup 7, 85,100E

    2012

    Biomass fuel (primarily wood), indoor emissions fromhousehold combustion of

    2A 95 2010

    002168-68-5 Bis(1-aziridinyl)morpholinophosphine sulfide 3 9, Sup 7 1987

    003296-90-0 2,2-Bis(bromomethyl)propane-1,3-diol 2B 77 2000

    000111-44-4 Bis(2-chloroethyl)ether 3 9, Sup 7, 71 1999

    000494-03-1 N,N-Bis(2-chloroethyl)-2-naphthylamine (seeChlornaphazine)

    000154-93-8 Bischloroethyl nitrosourea (BCNU) 2A 26, Sup 7 1987013483-18-6 1,2-Bis(chloromethoxy)ethane 3 15; Sup 7, 71 1999

    056894-91-8 1,4-Bis(chloromethoxymethyl)benzene 3 15; Sup 7, 71 1999

    000542-88-1

    000107-30-2

    Bis(chloromethyl)ether; chloromethyl methyl ether(technical-grade)

    1 4, Sup 7,100F

    2012

    000108-60-1 Bis(2-chloro-1-methylethyl)ether 3 41, Sup 7, 71 1999

    002386-90-5 Bis(2,3-epoxycyclopentyl)ether 3 47, 71 1999

    000117-81-7 Bis(2-ethylhexyl) phthalate (see Di(2-ethylhexyl)phthalate)

    001675-54-3 Bisphenol A diglycidyl ether (Araldite) 3 47, 71 1999

    Bisulfites 3 54 1992

    008052-42-4 Bitumens, extracts of steam-refined and air-refined;steam-refined, cracking-residue and air-refinedbitumens(see Bitumens, occupational exposures)

    35, Sup 7 1987

    Bitumens, occupational exposure to hard bitumens andtheir emissions during mastic asphalt work

    2B 103 2013

    064742-93-4 Bitumens, occupational exposure to oxidized bitumensand their emissions during roofing

    2A 103 2013

    008052-42-4064741-56-6

    Bitumens, occupational exposure to straight-run bitumensand their emissions during road paving

    2B 103 2013

    BK polyomavirus (BKV) 2B 104 2013

    011056-06-7 Bleomycins(NB: Overall evaluation upgraded to Group 2B withsupporting evidence from other relevant data)

    2B 26, Sup 7 1987

    000129-17-9 Blue VRS 3 16, Sup 7 1987

    Boot and shoe manufacture and repair (see Leather dust,Benzene)

    25, Sup 7 1987

    Bracken fern 2B 40, Sup 7 1987

    003844-45-9 Brilliant Blue FCF, disodium salt 3 16, Sup 7 1987

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    Agents Classif ied by the IARC Monographs, Volumes 1111

    CAS No Agent Group Volume Year

    005589-96-8 Bromochloroacetic acid 2B 101 2013

    083463-62-1 Bromochloroacetonitrile 3 52, 71 1999

    000075-27-4 Bromodichloromethane 2B 52, 71 1999

    000074-96-4 Bromoethane 3 52, 71 1999

    000075-25-2 Bromoform 3 52, 71 1999

    000055-98-1 Busulfan 1 4, Sup 7,100A

    2012

    000106-99-0 1,3-Butadiene 1 Sup 7, 54,71, 97, 100F

    2012

    000055-98-1 1,4-Butanediol dimethanesulfonate (see Busulfan)

    000111-76-2 2-Butoxyethanol 3 88 2006

    057018-52-7 1-tert-Butoxypropan-2-ol 3 88 2006

    000141-32-2 n-Butyl acrylate 3 39, Sup 7, 71 1999

    025013-16-5 Butylated hydroxyanisole (BHA) 2B 40, Sup 7 1987

    000128-37-0 Butylated hydroxytoluene (BHT) 3 40, Sup 7 1987

    000085-68-7 Butyl benzyl phthalate 3 Sup 7, 73 1999

    003068-88-0 beta-Butyrolactone 2B 11, Sup 7, 71 1999

    000096-48-0 gamma-Butyrolactone 3 11, Sup 7, 71 1999

    007440-43-9 Cadmium and cadmium compounds 1 58, 100C 2012

    000331-39-5 Caffeic acid 2B 56 1993

    000058-08-2 Caffeine 3 51 1991

    Calcium carbide production 3 92 2010000056-25-7 Cantharidin 3 10, Sup 7 1987

    000105-60-2 Caprolactam 4 39, Sup 7, 71 1999

    002425-06-1 Captafol(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 53 1991

    000133-06-2 Captan 3 30, Sup 7 1987

    000063-25-2 Carbaryl 3 12, Sup 7 1987

    000086-74-8 Carbazole 2B 32, Sup 7,71, 103

    2013

    020073-24-9 3-Carbethoxypsoralen 3 40, Sup 7 1987

    001333-86-4 Carbon black 2B Sup 7, 65, 93 2010

    Carbon electrode manufacture 2A 92 2010

    308068-56-6 Carbon nanotubes, multi-walled MWCNT-7 2B 111 In prep

    308068-56-6 Carbon nanotubes, multi-walled, other than MWCNT-7 3 111 In prep

    308068-56-6 Carbon nanotubes, single-walled 3 111 In prep

    000056-23-5 Carbon tetrachloride 2B 20, Sup 7, 71 1999

    003567-69-9 Carmoisine 3 8, Sup 7 1987

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    Agents Classif ied by the IARC Monographs, Volumes 1111

    CAS No Agent Group Volume Year

    Carpentry and joinery 2B 25, Sup 7 1987

    053973-98-1 Carrageenan, degraded (Poligeenan) 2B 31, Sup 7 1987

    009000-07-1 Carrageenan, native 3 31, Sup 7 1987

    000120-80-9 Catechol 2B 15, Sup 7, 71 1999

    Chimney sweeping (see Soot) 92 2010

    000075-87-6 Chloral 2A 63, 84, 106 2014

    000302-17-0 Chloral hydrate 2A 63, 84, 106 2014

    000305-03-3 Chlorambucil 1 26, Sup 7,100A

    2012

    010599-90-3 Chloramine 3 84 2004

    000056-75-7 Chloramphenicol

    (NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A Sup 7, 50 1990

    000057-74-9 Chlordane 2B Sup 7, 53, 79 2001

    000143-50-0 Chlordecone (Kepone) 2B 20, Sup 7 1987

    006164-98-3 Chlordimeform 3 30, Sup 7 1987

    000115-28-6 Chlorendic acid 2B 48 1990

    Chlorinated drinking-water 3 52 1991

    Chlorinated paraffins of average carbon chain length C12and average degree of chlorination approximately 60%

    2B 48 1990

    000098-87-3

    000098-07-7

    000100-44-7

    000098-88-4

    alpha-Chlorinated toluenes (benzal chloride,benzotrichloride, benzyl chloride) and benzoyl chloride

    (combined exposures)

    2A 29, Sup 7, 71 1999

    000494-03-1 Chlornaphazine 1 4, Sup 7,100A

    2012

    000107-14-2 Chloroacetonitrile 3 52, 71 1999

    000106-47-8 para-Chloroaniline 2B 57 1993

    000510-15-6 Chlorobenzilate 3 30, Sup 7 1987

    000124-48-1 Chlorodibromomethane 3 52, 71 1999

    077439-76-0 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone 2B 84 2004

    000075-45-6 Chlorodifluoromethane 3 41, Sup 7, 71 1999

    000075-00-3 Chloroethane 3 52, 71 1999

    013010-47-4 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 26, Sup 7 1987

    013909-09-6 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea(Methyl-CCNU) (see Semustine)

    000593-70-4 Chlorofluoromethane 3 41, Sup 7, 71 1999

    000067-66-3 Chloroform 2B Sup 7, 73 1999

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    Agents Classif ied by the IARC Monographs, Volumes 1111

    CAS No Agent Group Volume Year

    000107-30-2 Chloromethyl methyl ether (see Bis(chloromethyl)ether;chloromethyl methyl ether)

    000513-37-1 1-Chloro-2-methylpropene 2B 63 1995

    000563-47-3 3-Chloro-2-methylpropene 3 63 1995

    000088-73-3

    000121-73-3

    000100-00-5

    Chloronitrobenzenes 3 65 1996

    Chlorophenols (see Polychlorophenols)

    Chlorophenoxy herbicides 2B 41, Sup 7 1987

    005131-60-2 4-Chloro-meta-phenylenediamine 3 27, Sup 7 1987

    000095-83-0 4-Chloro-ortho-phenylenediamine 2B 27, Sup 7 1987

    000126-99-8 Chloroprene 2B Sup 7, 71 1999

    000101-21-3 Chloropropham 3 12, Sup 7 1987

    000054-05-7 Chloroquine 3 13, Sup 7 1987

    001897-45-6 Chlorothalonil 2B Sup 7, 73 1999

    000095-69-2 4-Chloro-ortho-toluidine 2A 77, 99 2010

    000095-79-4 5-Chloro-ortho-toluidine 3 77, 99 2010

    000075-88-7 2-Chloro-1,1,1-trifluoroethane 3 41, Sup 7, 71 1999

    054749-90-5 Chlorozotocin(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 50 1990

    000057-88-5 Cholesterol 3 31, Sup 7 1987007440-47-3 Chromium, metallic 3 Sup 7, 49 1990

    016065-83-1 Chromium (III) compounds 3 49 1990

    018540-29-9 Chromium (VI) compounds 1 Sup 7, 49,100C

    2012

    000218-01-9 Chrysene 2B 92 2010

    000532-82-1 Chrysoidine 3 8, Sup 7 1987

    006373-74-6 CI Acid Orange 3 3 57 1993

    000523-44-4 CI Acid Orange 20 3 8, Sup 7 1987

    006459-94-5 CI Acid Red 114 2B 57 1993

    000569-61-9 CI Basic Red 9 2B 57, 99 2010

    001937-37-7 CI Direct Black 38 (see Benzidine, dyes metabolized to)

    002602-46-2 CI Direct Blue 6 (see Benzidine, dyes metabolized to)

    002429-74-5 CI Direct Blue 15 2B 57 1993

    016071-86-6 CI Direct Brown 95 (see Benzidine, dyes metabolized to)

    001936-15-8 CI Orange G 3 8, Sup 7 1987

    002425-85-6 CI Pigment Red 3 3 57 1993

    059865-13-3 Ciclosporin (see Cyclosporine)

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    Agents Classif ied by the IARC Monographs, Volumes 1111

    CAS No Agent Group Volume Year

    051481-61-9 Cimetidine 3 50 1990

    000087-29-6 Cinnamyl anthranilate 3 Sup 7, 77 2000

    015663-27-1 Cisplatin(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 26, Sup 7 1987

    000518-75-2 Citrinin 3 40, Sup 7 1987

    006358-53-8 Citrus Red No. 2 2B 8, Sup 7 1987

    000637-07-0 Clofibrate 3 Sup 7, 66 1996

    000050-41-9 Clomiphene citrate 3 21, Sup 7 1987

    Clonorchis sinensis(infection with) 1 61, 100B 2012

    Coal, indoor emissions from household combustion of 1 95, 100E 2012

    Coal dust 3 68 1997

    Coal gasification 1 Sup 7, 92,100F

    2012

    008007-45-2 Coal tars (see Coal-tar distillation) 35, Sup 7 1987

    008007-45-2 Coal-tar distillation 1 92, 100F 2012

    065996-93-2 Coal-tar pitch 1 35, Sup 7,100F

    2012

    007440-48-4 Cobalt and cobalt compounds(NB: Evaluated as a group)

    2B 52 1991

    007440-48-4

    012070-12-1

    Cobalt metal with tungsten carbide 2A 86 2006

    007440-48-4 Cobalt metal without tungsten carbide 2B 86 2006

    010026-24-1 Cobalt sulfate and other soluble cobalt(II) salts 2B 86 2006

    068603-42-9 Coconut oil diethanolamine condensate 2B 101 2013

    Coffee (urinary bladder)(NB: There is some evidence of an inverse relationshipbetween coffee drinking and cancer of the large bowel;coffee drinking could not be classified as to itscarcinogenicity to other organs)

    2B 51 1991

    Coke production 1 Sup 7, 92,100F

    2012

    Continuous glass filament (see Glass filament)

    010380-28-6 Copper 8-hydroxyquinoline 3 15, Sup 7 1987

    000191-07-1 Coronene 3 32, Sup 7, 92 1987

    000091-64-5 Coumarin 3 Sup 7, 77 2000

    008001-58-9 Creosotes 2A Sup 7, 92 2010

    000102-50-1 meta-Cresidine 3 27, Sup 7 1987

    000120-71-8 para-Cresidine 2B 27, Sup 7 1987

    004170-30-3 Crotonaldehyde 3 63 1995

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    Agents Classif ied by the IARC Monographs, Volumes 1111

    CAS No Agent Group Volume Year

    008002-05-9 Crude oil 3 45 1989

    000098-82-8 Cumene 2B 101 2013

    014901-08-7 Cycasin 2B 10, Sup 7 1987

    000139-05-9 Cyclamates (sodium cyclamate) 3 Sup 7, 73 1999

    012663-46-6 Cyclochlorotine 3 10, Sup 7 1987

    000108-94-1 Cyclohexanone 3 47, 71 1999

    000202-98-2 4H-Cyclopenta[def]chrysene 3 92 2010

    027208-37-3 Cyclopenta[cd]pyrene(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A Sup 7, 92 2010

    007099-43-6 5,6-Cyclopenteno-1,2-benzanthracene 3 92 2010

    000050-18-0006055-19-2

    Cyclophosphamide 1 26, Sup 7,100A

    2012

    059865-13-3

    079217-60-0

    Cyclosporine 1 50, 100A 2012

    004342-03-4 Dacarbazine 2B 26, Sup 7 1987

    005160-02-1 D & C Red No. 9 3 Sup 7, 57 1993

    000117-10-2 Dantron (Chrysazin; 1,8-Dihydroxyanthraquinone) 2B 50 1990

    000080-08-0 Dapsone 3 24, Sup 7 1987

    020830-81-3 Daunomycin 2B 10, Sup 7 1987

    000050-29-3 DDT (4,4'-Dichlorodiphenyltrichloroethane) 2B Sup 7, 53 1991

    001163-19-5 Decabromodiphenyl oxide 3 48, 71 1999052918-63-5 Deltamethrin 3 53 1991

    000083-63-6 Diacetylaminoazotoluene 3 8, Sup 7 1987

    000613-35-4 N,N'-Diacetylbenzidine 2B 16, Sup 7 1987

    002303-16-4 Diallate 3 30, Sup 7 1987

    000615-05-4 2,4-Diaminoanisole 2B Sup 7, 79 2001

    000101-80-4 4,4'-Diaminodiphenyl ether 2B 29, Sup 7 1987

    000099-56-9 1,2-Diamino-4-nitrobenzene 3 16, Sup 7 1987

    005307-14-2 1,4-Diamino-2-nitrobenzene 3 Sup 7, 57 1993

    000095-80-7 2,4-Diaminotoluene 2B 16, Sup 7 1987

    000095-70-5 2,5-Diaminotoluene 3 16, Sup 7 1987000439-14-5 Diazepam 3 Sup 7, 66 1996

    000334-88-3 Diazomethane 3 7, Sup 7 1987

    000226-36-8 Dibenz[a,h]acridine 2B 32, Sup 7,103

    2013

    000224-42-0 Dibenz[a,j]acridine(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 32, Sup 7,103

    2013

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    Agents Classif ied by the IARC Monographs, Volumes 1111

    CAS No Agent Group Volume Year

    000224-53-3 Dibenz[c,h]acridine(NB: Overall evaluation upgraded to Group 2B withsupporting evidence from other relevant data)

    2B 103 2013

    000215-58-7 Dibenz[a,c]anthracene 3 Sup 7, 92 2010

    000053-70-3 Dibenz[a,h]anthracene(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A Sup 7, 92 2010

    000224-41-9 Dibenz[a,j]anthracene 3 Sup 7, 92 2010

    000194-59-2 7H-Dibenzo[c,g]carbazole 2B 32, Sup 7,103

    2013

    000262-12-4 Dibenzo-para-dioxin 3 69 1997

    005385-75-1 Dibenzo[a,e]fluoranthene 3 Sup 7, 92 2010

    000207-83-0 13H-Dibenzo[a,g]fluorene 3 92 2010

    000192-47-2 Dibenzo[h,rst]pentaphene 3 Sup 7, 92 2010

    000192-65-4 Dibenzo[a,e]pyrene 3 Sup 7, 92 2010

    000189-64-0 Dibenzo[a,h]pyrene 2B Sup 7, 92 2010

    000189-55-9 Dibenzo[a,i]pyrene 2B 92 2010

    000191-30-0 Dibenzo[a,l]pyrene(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A Sup 7, 92 2010

    000192-51-8 Dibenzo[e,l]pyrene 3 92 2010

    000132-65-0 Dibenzothiophene 3 103 2013

    000631-64-1 Dibromoacetic acid 2B 101 2013003252-43-5 Dibromoacetonitrile 2B 52, 71, 101 2013

    000096-12-8 1,2-Dibromo-3-chloropropane 2B 20, Sup 7, 71 1999

    000096-13-9 2,3-Dibromopropan-1-ol 2B 77 2000

    000079-43-6 Dichloroacetic acid 2B 63, 84, 106 2014

    003018-12-0 Dichloroacetonitrile 3 52, 71 1999

    007572-29-4 Dichloroacetylene 3 39, Sup 7, 71 1999

    000541-73-1 meta-Dichlorobenzene 3 73 1999

    000095-50-1 ortho-Dichlorobenzene 3 Sup 7, 73 1999

    000106-46-7 para-Dichlorobenzene 2B Sup 7, 73 1999

    000091-94-1 3,3'-Dichlorobenzidine 2B 29, Sup 7 1987000110-57-6 trans-1,4-Dichlorobutene 3 15, Sup 7, 71 1999

    028434-86-8 3,3'-Dichloro-4,4'-diaminodiphenyl ether 2B 16, Sup 7 1987

    000107-06-2 1,2-Dichloroethane 2B 20, Sup 7, 71 1999

    000075-09-2 Dichloromethane (Methylene chloride) 2A Sup 7, 71,110

    in prep

    000609-20-1 2,6-Dichloro-para-phenylenediamine 3 39, Sup 7 1987

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    CAS No Agent Group Volume Year

    000078-87-5 1,2-Dichloropropane 1 41, Sup 7,71, 110

    in prep

    000096-23-1 1,3-Dichloro-2-propanol 2B 101 2013

    000542-75-6 1,3-Dichloropropene (technical-grade) 2B 41, Sup 7, 71 1999

    000062-73-7 Dichlorvos 2B Sup 7, 53 1991

    000115-32-2 Dicofol 3 30, Sup 7 1987

    069655-05-6 Didanosine 3 76 2000

    000060-57-1 Dieldrin 3 5, Sup 7 1987

    001464-53-5 1,2:3,4-Diepoxybutane (see Monographson 1,3-Butadiene)

    11, Sup 7 1987

    Diesel engine exhaust (see Engine exhaust, diesel)

    Diesel fuels, distillate (light) 3 45 1989

    Diesel fuel, marine(NB: Overall evaluation upgraded to Group 2B withsupporting evidence from other relevant data)

    2B 45 1989

    000111-42-2 Diethanolamine 2B 77, 101 2013

    000103-23-1 Di(2-ethylhexyl) adipate 3 Sup 7, 77 2000

    000117-81-7 Di(2-ethylhexyl)phthalate 2B Sup 7, 77,101

    2013

    001615-80-1 1,2-Diethylhydrazine 2B 4, Sup 7, 71 1999

    000056-53-1 Diethylstilbestrol 1 21, Sup 7,100A

    2012

    000064-67-5 Diethyl sulfate(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 54, 71 1999

    000105-55-5 N,N'-Diethylthiourea 3 79 2001

    000101-90-6 Diglycidyl resorcinol ether 2B 36, Sup 7, 71 1999

    020830-75-5 Digoxin 2B 108 in prep

    000641-48-5 Dihydroaceanthrylene 3 92 2010

    000094-58-6 Dihydrosafrole 2B 10, Sup 7 1987

    000794-93-4 Dihydroxymethylfuratrizine (see also Panfuran S) 3 24, Sup 7 1987

    002973-10-6 Diisopropyl sulfate 2B 54, 71 1999

    000828-00-2 Dimethoxane 3 15, Sup 7 1987000119-90-4 3,3'-Dimethoxybenzidine (ortho-Dianisidine) 2B 4, Sup 7 1987

    000091-93-0 3,3'-Dimethoxybenzidine-4,4'-diisocyanate 3 39, Sup 7 1987

    000060-11-7 para-Dimethylaminoazobenzene 2B 8, Sup 7 1987

    000140-56-7 para-Dimethylaminoazobenzenediazo sodium sulfonate 3 8, Sup 7 1987

    025962-77-0 trans-2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-2-furyl)-vinyl]-1,3,4-oxadiazole

    2B 7, Sup 7 1987

    022975-76-4 4,4'-Dimethylangelicin plus ultraviolet A radiation 3 Sup 7 1987

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    CAS No Agent Group Volume Year

    004063-41-6 4,5'-Dimethylangelicin plus ultraviolet A radiation 3 Sup 7 1987

    000087-62-7 2,6-Dimethylaniline (2,6-Xylidine) 2B 57 1993

    000121-69-7 N,N-Dimethylaniline 3 57 1993

    000075-60-5 Dimethylarsinic acid 2B 100C 2012

    000119-93-7 3,3'-Dimethylbenzidine (ortho-Tolidine) 2B 1, Sup 7 1987

    000079-44-7 Dimethylcarbamoyl chloride(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 12, Sup 7, 71 1999

    000068-12-2 Dimethylformamide 3 47, 71 1999

    000057-14-7 1,1-Dimethylhydrazine 2B 4, Sup 7, 71 1999

    000540-73-8 1,2-Dimethylhydrazine

    (NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 4, Sup 7, 71 1999

    000868-85-9 Dimethyl hydrogen phosphite 3 48, 71 1999

    022349-59-3 1,4-Dimethylphenanthrene 3 Sup 7, 92 2010

    000077-78-1 Dimethyl sulfate(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 4, Sup 7, 71 1999

    105735-71-5 3,7-Dinitrofluoranthene 2B 46, 65, 105 2013

    022506-53-2 3,9-Dinitrofluoranthene 2B 46, 65, 105 2013

    075321-20-9 1,3-Dinitropyrene 2B 46, 105 2013

    042397-64-8 1,6-Dinitropyrene 2B 46, 105 2013

    042397-65-9 1,8-Dinitropyrene 2B Sup 7, 46,105

    2013

    000101-25-7 Dinitrosopentamethylenetetramine 3 11, Sup 7 1987

    000121-14-2 2,4-Dinitrotoluene 2B 65 1996

    000606-20-2 2,6-Dinitrotoluene 2B 65 1996

    000618-85-9 3,5-Dinitrotoluene 3 65 1996

    000123-91-1 1,4-Dioxane 2B 11, Sup 7, 71 1999

    000492-17-1 2,4'-Diphenyldiamine 3 16, Sup 7 1987

    002475-45-8 Disperse Blue 1 2B 48 1990

    002832-40-8 Disperse Yellow 3 3 48 1990

    000097-77-8 Disulfiram 3 12, Sup 7 1987001143-38-0 Dithranol 3 13; Sup 7 1987

    040762-15-0 Doxefazepam 3 66 1996

    000562-10-7 Doxylamine succinate 3 79 2001

    082413-20-5 Droloxifene 3 66 1996

    Dry cleaning (occupational exposures in) 2B 63 1995

    000150-69-6 Dulcin 3 12, Sup 7 1987

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    CAS No Agent Group Volume Year

    Dyes metabolized to benzidine (see Benzidine, dyesmetabolized to)

    Electric fields, extremely low-frequency 3 80 2002

    Electric fields, static 3 80 2002

    000072-20-8 Endrin 3 5, Sup 7 1987

    Engine exhaust, diesel 1 46, 105 2013

    Engine exhaust, gasoline 2B 46, 105 2013

    015086-94-9 Eosin 3 15, Sup 7 1987

    000106-89-8 Epichlorohydrin(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 11, Sup 7, 71 1999

    000106-88-7 1,2-Epoxybutane(NB: Overall evaluation upgraded to Group 2B withsupporting evidence from other relevant data)

    2B 47, 71 1999

    000141-37-7 3,4-Epoxy-6-methylcyclohexylmethyl-3,4-epoxy-6-methylcyclo-hexanecarboxylate

    3 11, Sup 7, 71 1999

    024560-98-3 cis-9,10-Epoxystearic acid 3 11, Sup 7, 71 1999

    Epstein-Barr virus 1 70, 100B 2012

    066733-21-9 Erionite 1 42, Sup 7,100C

    2012

    029975-16-4 Estazolam 3 66 1996

    Estrogen therapy, postmenopausal 1 72, 100A 2012

    Estrogen-progestogen menopausal therapy (combined) 1 72, 91, 100A 2012Estrogen-progestogen oral contraceptives (combined)

    (NB: There is also convincing evidence in humans thatthese agents confer a protective effect against cancer inthe endometrium and ovary)

    1 72, 91, 100A 2012

    000064-17-5 Ethanol in alcoholic beverages 1 96, 100E 2012

    000536-33-4 Ethionamide 3 13, Sup 7 1987

    000140-88-5 Ethyl acrylate 2B 39, Sup 7, 71 1999

    000100-41-4 Ethylbenzene 2B 77 2000

    000051-79-6 Ethyl carbamate (Urethane) 2A 7, Sup 7, 96 2010

    000074-85-1 Ethylene 3 Sup 7, 60 1994

    000106-93-4 Ethylene dibromide(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 15, Sup 7, 71 1999

    000075-21-8 Ethylene oxide(NB: Overall evaluation upgraded to Group 1 based onmechanistic and other relevant data)

    1 Sup 7, 60,97, 100F

    2012

    000420-12-2 Ethylene sulfide 3 11, Sup 7 1987

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    CAS No Agent Group Volume Year

    000096-45-7 Ethylenethiourea(NB: Overall evaluation downgraded to Group 3 withsupporting evidence from other relevant data)

    3 Sup 7, 79 2001

    000103-11-7 2-Ethylhexyl acrylate 3 60 1994

    000062-50-0 Ethyl methanesulfonate 2B 7, Sup 7 1987

    000759-73-9 N-Ethyl-N-nitrosourea(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 17, Sup 7 1987

    005456-28-0 Ethyl selenac 3 12, Sup 7 1987

    020941-65-5 Ethyl tellurac 3 12, Sup 7 1987

    033419-42-0 Etoposide(NB: Overall evaluation upgraded to Group 1 based on

    mechanistic and other relevant data)

    1 76, 100A 2012

    033419-42-0

    015663-27-1

    011056-06-7

    Etoposide in combination with cisplatin and bleomycin 1 76, 100A 2012

    000097-53-0 Eugenol 3 36, Sup 7 1987

    000314-13-6 Evans blue 3 8, Sup 7 1987

    002353-45-9 Fast Green FCF 3 16, Sup 7 1987

    051630-58-1 Fenvalerate 3 53 1991

    014484-64-1 Ferbam 3 12, Sup 7 1987

    001309-37-1 Ferric oxide 3 1, Sup 7 1987

    Firefighter (occupational exposure as a) 2B 98 2010

    Fission products, including strontium-90 1 100D 2012

    Flat-glass and specialty glass (manufacture of) 3 58 1993

    002164-17-2 Fluometuron 3 30, Sup 7 1987

    000206-44-0 Fluoranthene 3 Sup 7, 92 2010

    000086-73-7 Fluorene 3 Sup 7, 92 2010

    Fluorescent lighting 3 55 1992

    016984-48-8 Fluorides (inorganic, used in drinking-water) 3 27, Sup 7 1987

    Fluoro-edenite fibrous amphibole 1 111 In prep

    000051-21-8 5-Fluorouracil 3 26, Sup 7 1987

    Foreign bodies (see Surgical implants and other foreignbodies)

    000050-00-0 Formaldehyde 1 Sup 7, 62,88, 100F

    2012

    003570-75-0 2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole 2B 7, Sup 7 1987

    Frying, emissions from high-temperature 2A 95 2010

    Fuel oils, distillate (light) 3 45 1989

    Fuel oils, residual (heavy) 2B 45 1989

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    CAS No Agent Group Volume Year

    116355-83-0 Fumonisin B1 2B 82 2002

    000110-00-9 Furan 2B 63 1995

    000067-45-8 Furazolidone 3 31, Sup 7 1987

    000098-01-1 Furfural 3 63 1995

    Furniture and cabinet making (see Wood dust) 25, Sup 7 1987

    000054-31-9 Furosemide (Frusemide) 3 50 1990

    Fusarium graminearum, F. culmorum,and F.crookwellense, toxins derived from (zearalenone,deoxynivalenol, nivalenol, and fusarenone X)

    3 Sup 7, 56 1993

    116355-83-0 Fusarium moniliforme, toxins derived from (fumonisin B1,fumonisin B2, and fusarin C)

    2B 56 1993

    Fusarium sporotrichioides, toxins derived from (T-2 toxin) 3 56 1993001303-00-0 Gallium arsenide (see Arsenic and inorganic arsenic

    compounds)86, 100C 2012

    Gamma-Radiation (see X- and Gamma-Radiation)

    Gasoline(NB: Overall evaluation upgraded to Group 2B withsupporting evidence from other relevant data)

    2B 45 1989

    Gasoline engine exhaust (see Engine exhaust, gasoline)

    025812-30-0 Gemfibrozil 3 66 1996

    090045-36-6 Ginkgo bilobaextract 2B 108 in prep

    Glass filament, continuous 3 43, 81 2002

    067730-11-4 Glu-P-1 (2-Amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole)

    2B 40, Sup 7 1987

    067730-10-3 Glu-P-2 (2-Aminodipyrido[1,2-a:3',2'-d]imidazole) 2B 40, Sup 7 1987

    000765-34-4 Glycidaldehyde 2B 11, Sup 7, 71 1999

    000556-52-5 Glycidol(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 77 2000

    005431-33-4 Glycidyl oleate 3 11, Sup 7 1987

    007460-84-6 Glycidyl stearate 3 11, Sup 7 1987

    Goldenseal root powder 2B 108 in prep

    000126-07-8 Griseofulvin 2B Sup 7, 79 2001

    004680-78-8 Guinea Green B 3 16, Sup 7 1987

    016568-02-8 Gyromitrin 3 31, Sup 7 1987

    001317-60-8 Haematite 3 1, Sup 7 1987

    Haematite mining (underground) 1 1, Sup 7,100D

    2012

    Hair colouring products (personal use of) 3 57, 99 2010

    Hairdresser or barber (occupational exposure as a) 2A 57, 99 2010

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    CAS No Agent Group Volume Year

    002784-94-3 HC Blue No. 1 2B 57 1993

    033229-34-4 HC Blue No. 2 3 57 1993

    002871-01-4 HC Red No. 3 3 57 1993

    059820-43-8 HC Yellow No. 4 3 57 1993

    Helicobacter pylori(infection with) 1 61, 100B 2012

    Hepatitis B virus (chronic infection with) 1 59, 100B 2012

    Hepatitis C virus (chronic infection with) 1 59, 100B 2012

    Hepatitis D virus 3 59 1994

    000076-44-8 Heptachlor 2B Sup 7, 53, 79 2001

    000118-74-1 Hexachlorobenzene 2B Sup 7, 79 2001

    000087-68-3 Hexachlorobutadiene 3 73 1999

    Hexachlorocyclohexanes 2B 20, Sup 7 1987

    000067-72-1 Hexachloroethane 2B 73 1999

    000070-30-4 Hexachlorophene 3 20, Sup 7 1987

    000142-83-6 2,4-Hexadienal 2B 101 2013

    000680-31-9 Hexamethylphosphoramide 2B 15, Sup 7, 71 1999

    High-temperature frying (see Frying)

    Hot mate (see Mate, hot)

    Household combustion of biomass fuel (see Biomassfuel, indoor emissions from household combustion of)

    Household combustion of coal (see Coal, indoor

    emissions from household combustion)Human herpesvirus type 4 (see Epstein-Barr virus)

    Human herpesvirus type 8 (see Kaposi sarcomaherpesvirus)

    Human immunodeficiency virus type 1 (infection with) 1 67, 100B 2012

    Human immunodeficiency virus type 2 (infection with) 2B 67 1996

    Human papillomavirus genus beta (except types 5 and 8)and genus gamma

    3 90, 100B 2012

    Human papillomavirus types 5 and 8 (in patients withepidermodysplasia verruciformis)

    2B 100B 2012

    Human papillomavirus types 6 and 11 3 90, 100B 2012

    Human papillomavirus types 16, 18, 31, 33, 35, 39, 45,51, 52, 56, 58, 59(NB: The HPV types that have been classified ascarcinogenic to humanscan differ by an order ofmagnitude in risk for cervical cancer)

    1 64, 90, 100B 2012

    Human papillomavirus types 26, 53, 66, 67, 70, 73, 82 2B 100B 2012

    Human papillomavirus types 30, 34, 69, 85, 97(NB: Classified by phylogenetic analogy to the HPVgenus alpha types classified in Group 1)

    2B 100B 2012

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    CAS No Agent Group Volume Year

    Human papillomavirus type 68 2A 100B 2012

    Human T-cell lymphotropic virus type I 1 67, 100B 2012

    Human T-cell lymphotropic virus type II 3 67 1996

    023255-93-8 Hycanthone mesylate 3 13, Sup 7 1987

    000086-54-4 Hydralazine 3 24, Sup 7 1987

    000302-01-2 Hydrazine 2B 4, Sup 7, 71 1999

    007647-01-0 Hydrochloric acid 3 54 1992

    000058-93-5 Hydrochlorothiazide 2B 50, 108 in prep

    007722-84-1 Hydrogen peroxide 3 36, Sup 7, 71 1999

    000123-31-9 Hydroquinone 3 15, Sup 7, 71 1999

    000129-43-1 1-Hydroxyanthraquinone 2B 82 2002

    001689-82-3 4-Hydroxyazobenzene 3 8, Sup 7 1987

    000148-24-3 8-Hydroxyquinoline 3 13, Sup 7 1987

    026782-43-4 Hydroxysenkirkine 3 10, Sup 7 1987

    000127-07-1 Hydroxyurea 3 76 2000

    Hypochlorite salts 3 52 1991

    000193-39-5 Indeno[1,2,3-cd]pyrene 2B Sup 7, 92 2010

    022398-80-7 Indium phosphide(NB: Overall evaluation upgraded to Group 2A)

    2A 86 2006

    Insulation glass wool 3 43, 81 2002

    Involuntary smoking (see Tobacco smoke, second-hand)

    010043-66-0 Iodine-131 (see Radioiodines)

    Ionizing radiation (all types) 1 100D 2012

    076180-96-6 IQ (2-Amino-3-methylimidazo[4,5-f]quinoline)(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A Sup 7, 56 1993

    Iron and steel founding (occupational exposure during) 1 34, Sup 7,100F

    2012

    009004-66-4 Iron-dextran complex 2B 2, Sup 7 1987

    009004-51-7 Iron-dextrin complex 3 2, Sup 7 1987

    001338-16-5 Iron sorbitol-citric acid complex 3 2, Sup 7 1987

    015503-86-3 Isatidine 3 10, Sup 7 1987

    000054-85-3 Isonicotinic acid hydrazide (Isoniazid) 3 4, Sup 7 1987

    003778-73-2 Isophosphamide 3 26, Sup 7 1987

    000078-79-5 Isoprene 2B 60, 71 1999

    000067-63-0 Isopropyl alcohol 3 15, Sup 7, 71 1999

    Isopropyl alcohol manufacture using strong acids 1 Sup 7, 100F 2012

    Isopropyl oils 3 15, Sup 7, 71 1999

    000120-58-1 Isosafrole 3 10, Sup 7 1987

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    CAS No Agent Group Volume Year

    006870-67-3 Jacobine 3 10, Sup 7 1987

    JC polyomavirus (JCV) 2B 104 2013

    Jet fuel 3 45 1989

    000520-18-3 Kaempferol 3 31, Sup 7 1987

    Kaposi sarcoma herpesvirus 1 70, 100B 2012

    009000-38-8 Kava extract 2B 108 in prep

    000501-30-4 Kojic acid 3 79 2001

    000303-34-4 Lasiocarpine 2B 10, Sup 7 1987

    000105-74-8 Lauroyl peroxide 3 36, Sup 7, 71 1999

    007439-92-1 Lead 2B 23, Sup 7 1987

    Lead compounds, inorganic 2A Sup 7, 87 2006

    Lead compounds, organic(NB: Organic lead compounds are metabolized at leastin part, to ionic lead both in humans and animals. To theextent that ionic lead, generated from organic lead, ispresent in the body, it will be expected to exert thetoxicities associated with inorganic lead.)

    3 23, Sup 7, 87 2006

    Leather dust 1 100C 2012

    Leather goods manufacture 3 25, Sup 7 1987

    Leather tanning and processing 3 25, Sup 7 1987

    005141-20-8 Light Green SF 3 16, Sup 7 1987

    005989-27-5 d-Limonene

    (NB: Overall evaluation downgraded to Group 3 withsupporting evidence from other relevant data)

    3 56, 73 1999

    Lumber and sawmill industries (including logging) 3 25, Sup 7 1987

    021884-44-6 Luteoskyrin 3 10, Sup 7 1987

    Madder root (Rubia tinctorum) 3 82 2002

    000632-99-5 Magenta 2B Sup 7, 57,99, 100F

    2012

    Magenta production 1 Sup 7, 57,99, 100F

    2012

    Magnetic fields, extremely low-frequency 2B 80 2002

    Magnetic fields, static 3 80 2002

    Malaria (caused by infection with Plasmodium falciparumin holoendemic areas)

    2A 104 2013

    000121-75-5 Malathion 3 30, Sup 7 1987

    000123-33-1 Maleic hydrazide 3 4, Sup 7 1987

    000542-78-9 Malonaldehyde 3 36, Sup 7, 71 1999

    012427-38-2 Maneb 3 12, Sup 7 1987

    000551-74-6 Mannomustine dihydrochloride 3 9, Sup 7 1987

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    CAS No Agent Group Volume Year

    Mate 3 51 1991

    Mate, hot 2A 51 1991

    068006-83-7 MeA-alpha-C (2-Amino-3-methyl-9H-pyrido[2,3-b]indole) 2B 40, Sup 7 1987

    013045-94-8 Medphalan 3 9, Sup 7 1987

    000071-58-9 Medroxyprogesterone acetate 2B 21, Sup 7 1987

    077094-11-2 MeIQ (2-Amino-3,4-dimethylimidazo[4,5-f]quinoline) 2B Sup 7, 56 1993

    077500-04-0 MeIQx (2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline) 2B Sup 7, 56 1993

    000108-78-1 Melamine(NB: Overall evaluation downgraded to Group 3 withsupporting evidence from other relevant data)

    3 Sup 7, 73 1999

    000148-82-3 Melphalan 1 9, Sup 7,

    100A

    2012

    000050-44-2 6-Mercaptopurine 3 26, Sup 7 1987

    007439-97-6 Mercury and inorganic mercury compounds 3 58 1993

    Merkel cell polyomavirus (MCV) 2A 104 2013

    000531-76-0 Merphalan 2B 9, Sup 7 1987

    Metabisulfites 3 54 1992

    000060-56-0 Methimazole 3 79 2001

    000059-05-2 Methotrexate 3 26, Sup 7 1987

    000072-43-5 Methoxychlor 3 20, Sup 7 1987

    000298-81-7 Methoxsalen (8-methoxypsoralen) plus ultraviolet Aradiation

    1 24, Sup 7,100A

    2012

    000484-20-8 5-Methoxypsoralen(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 40, Sup 7 1987

    000096-33-3 Methyl acrylate 3 39, Sup 7, 71 1999

    073459-03-7 5-Methylangelicin plus ultraviolet A radiation 3 Sup 7 1987

    000124-58-3 Methylarsonic acid 2B 100C 2012

    000075-55-8 2-Methylaziridine (Propyleneimine) 2B 9, Sup 7, 71 1999

    000592-62-1 Methylazoxymethanol acetate 2B 10, Sup 7 1987

    000074-83-9 Methyl bromide 3 41, Sup 7, 71 1999

    001634-04-4 Methyl tert-butyl ether 3 73 1999

    000598-55-0 Methyl carbamate 3 12, Sup 7 1987

    000074-87-3 Methyl chloride 3 41, Sup 7, 71 1999

    003351-28-8 1-Methylchrysene 3 Sup 7, 92 2010

    003351-32-4 2-Methylchrysene 3 Sup 7, 92 2010

    003351-31-3 3-Methylchrysene 3 Sup 7, 92 2010

    003351-30-2 4-Methylchrysene 3 Sup 7, 92 2010

    003697-24-3 5-Methylchrysene 2B Sup 7, 92 2010

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    CAS No Agent Group Volume Year

    001705-85-7 6-Methylchrysene 3 Sup 7, 92 2010

    000099-80-9 N-Methyl-N,4-dinitrosoaniline 3 1, Sup 7 1987

    000101-14-4 4,4'-Methylenebis(2-chloroaniline) (MOCA)(NB: Overall evaluation upgraded to Group 1 based onmechanistic and other relevant data)

    1 Sup 7, 57,99, 100F

    2012

    000838-88-0 4,4'-Methylene bis(2-methylaniline) 2B 4, Sup 7 1987

    007220-79-3 Methylene blue 3 108 in prep

    000101-77-9 4,4'-Methylenedianiline 2B 39, Sup 7 1987

    000101-68-8 4,4'-Methylenediphenyl diisocyanate 3 19, Sup 7, 71 1999

    000093-15-2 Methyleugenol 2B 101 2013

    033543-31-6 2-Methylfluoranthene 3 Sup 7, 92 2010

    001706-01-0 3-Methylfluoranthene 3 Sup 7, 92 2010

    000078-98-8 Methylglyoxal 3 51 1991

    000693-98-1 2-Methylimidazole 2B 101 2013

    000822-36-6 4-Methylimidazole 2B 101 2013

    000074-88-4 Methyl iodide 3 41, Sup 7, 71 1999

    000108-10-1 Methyl isobutyl ketone 2B 101 2013

    Methylmercury compounds(NB: Evaluated as a group)

    2B 58 1993

    000080-62-6 Methyl methacrylate 3 Sup 7, 60 1994

    000066-27-3 Methyl methanesulfonate(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 7, Sup 7, 71 1999

    000129-15-7 2-Methyl-1-nitroanthraquinone (uncertain purity) 2B 27, Sup 7 1987

    000070-25-7 N-Methyl-N-nitro-N-nitrosoguanidine (MNNG)(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 4, Sup 7 1987

    000684-93-5 N-Methyl-N-nitrosourea(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 17, Sup 7 1987

    000615-53-2 N-Methyl-N-nitrosourethane 2B 4, Sup 7 1987

    090456-67-0 N-Methylolacrylamide 3 60 1994

    000298-00-0 Methyl parathion 3 30, Sup 7 1987

    000832-69-9 1-Methylphenanthrene 3 Sup 7, 92 2010

    085878-63-3 7-Methylpyrido[3,4-c]psoralen 3 40, Sup 7 1987

    000493-52-7 Methyl red 3 8, Sup 7 1987

    000144-34-3 Methyl selenac 3 12, Sup 7 1987

    000098-83-9 -Methylstyrene 2B 101 2013

    000056-04-2 Methylthiouracil 2B Sup 7, 79 2001

    000443-48-1 Metronidazole 2B 13, Sup 7 1987

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    CAS No Agent Group Volume Year

    000101-61-1 Michlers base [4,4-methylenebis(N,N-dimethyl)-benzenamine]

    2B 27, Sup 7, 99 2010

    000090-94-8 Michlers ketone [4,4-Bis(dimethylamino)benzophenone] 2B 99 2010

    101043-37-2 Microcystin-LR 2B 94 2010

    Microcystisextracts 3 94 2010

    Mineral oils, highly-refined 3 33, Sup 7 1987

    Mineral oils, untreated or mildly treated 1 33, Sup 7,100F

    2012

    002385-85-5 Mirex 2B 20, Sup 7 1987

    000050-07-7 Mitomycin C 2B 10, Sup 7 1987

    065271-80-9 Mitoxantrone 2B 76 2000

    Modacrylic fibres 3 19, Sup 7 1987

    000096-24-2 3-Monochloro-1,2-propanediol 2B 101 2013

    000315-22-0 Monocrotaline 2B 10, Sup 7 1987

    000124-58-3 Monomethylarsonic acid (see Methylarsonic acid) 2B 100C 2012

    000150-68-5 Monuron 3 Sup 7, 53 1991

    MOPP and other combined chemotherapy includingalkylating agents

    1 Sup 7, 100A 2012

    000110-91-8 Morpholine 3 47, 71 1999

    003795-88-8 5-(Morpholinomethyl)-3-[(5-nitrofurfurylidene)amino]-2-oxazolidinone

    2B 7, Sup 7 1987

    308068-56-6 Multi-walled carbon nanotubes MWCNT-7 2B 111 In prep

    308068-56-6 Multi-walled carbon nanotubes other than MWCNT-7 3 111 In prep

    000083-66-9 Musk ambrette 3 65 1996

    000081-15-2 Musk xylene 3 65 1996

    000505-60-2 Mustard gas (see Sulfur mustard)

    000055-98-1 Myleran (see Busulfan)

    003771-19-5 Nafenopin 2B 24, Sup 7 1987

    000091-20-3 Naphthalene 2B 82 2002

    002243-62-1 1,5-Naphthalenediamine 3 27, Sup 7 1987

    003173-72-6 1,5-Naphthalene diisocyanate 3 19, Sup 7, 71 1999

    111189-32-3 Naphtho[1,2-b]fluoranthene 3 92 2010

    000203-20-3 Naphtho[2,1-a]fluoranthene 3 92 2010

    000193-09-9 Naphtho[2,3-e]pyrene 3 92 2010

    000134-32-7 1-Naphthylamine 3 4, Sup 7 1987

    000091-59-8 2-Naphthylamine 1 4, Sup 7, 99,100F

    2012

    000086-88-4 1-Naphthylthiourea (ANTU) 3 30, Sup 7 1987

    000139-94-6 Nithiazide 3 31, Sup 7 1987

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    CAS No Agent Group Volume Year

    Neutron radiation(NB: Overall evaluation upgraded to Group 1 withsupporting evidence from other relevant data)

    1 75, 100D 2012

    007440-02-0 Nickel, metallic and alloys 2B Sup 7, 49 1990

    Nickel compounds 1 Sup 7, 49,100C

    2012

    Nickel refining (see Nickel compounds) 11 1976

    000061-57-4 Niridazole 2B 13, Sup 7 1987

    Nitrate or nitrite (ingested) under conditions that result inendogenous nitrosation

    2A 94 2010

    000139-13-9 Nitrilotriacetic acid and its salts(NB: Evaluated as a group)

    2B 48, 73 1999

    000602-87-9 5-Nitroacenaphthene 2B 16, Sup 7 1987

    000099-59-2 5-Nitro-ortho-anisidine 3 27, Sup 7 1987

    000091-23-6 2-Nitroanisole 2B 65 1996

    000602-60-8 9-Nitroanthracene 3 33, Sup 7 1987

    017117-34-9 3-Nitrobenzanthrone 2B 105 2013

    000098-95-3 Nitrobenzene 2B 65 1996

    020268-51-3 7-Nitrobenz[a]anthracene 3 46 1989

    063041-90-7 6-Nitrobenzo[a]pyrene 3 Sup 7, 46 1989

    000092-93-3 4-Nitrobiphenyl 3 4, Sup 7 1987

    007496-02-8 6-Nitrochrysene 2A Sup 7, 46,

    105

    2013

    001836-75-5 Nitrofen (technical-grade) 2B 30, Sup 7 1987

    000892-21-7 3-Nitrofluoranthene 3 33, Sup 7 1987

    000607-57-8 2-Nitrofluorene 2B 46, 105 2013

    000059-87-0 Nitrofural (Nitrofurazone) 3 50 1990

    000067-20-9 Nitrofurantoin 3 50 1990

    000555-84-0 1-[(5-Nitrofurfurylidene)amino]-2-imidazolidinone 2B 7, Sup 7 1987

    000531-82-8 N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide 2B 7, Sup 7 1987

    000051-75-2 Nitrogen mustard 2A 9, Sup 7 1987

    000126-85-2 Nitrogen mustard N-oxide 2B 9, Sup 7 1987

    000075-52-5 Nitromethane 2B 77 2000

    000086-57-7 1-Nitronaphthalene 3 46 1989

    000581-89-5 2-Nitronaphthalene 3 46 1989

    020589-63-3 3-Nitroperylene 3 46 1989

    000079-46-9 2-Nitropropane 2B 29, Sup 7, 71 1999

    005522-43-0 1-Nitropyrene 2A Sup 7, 46,105

    2013

    000789-07-1 2-Nitropyrene 3 46 1989

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    CAS No Agent Group Volume Year

    057835-92-4 4-Nitropyrene 2B 46, 105 2013

    037620-20-5 N'-Nitrosoanabasine (NAB) 3 37, Sup 7, 89 2007

    071267-22-6 N'-Nitrosoanatabine (NAT) 3 37, Sup 7, 89 2007

    000924-16-3 N-Nitrosodi-n-butylamine 2B 17, Sup 7 1987

    001116-54-7 N-Nitrosodiethanolamine 2B 17, Sup 7, 77 2000

    000055-18-5 N-Nitrosodiethylamine(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 17, Sup 7 1987

    000062-75-9 N-Nitrosodimethylamine(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 17, Sup 7 1987

    000086-30-6 N-Nitrosodiphenylamine 3 27, Sup 7 1987000156-10-5 para-Nitrosodiphenylamine 3 27, Sup 7 1987

    000621-64-7 N-Nitrosodi-n-propylamine 2B 17, Sup 7 1987

    029291-35-8 N-Nitrosofolic acid 3 17, Sup 7 1987

    055557-01-2 N-Nitrosoguvacine 3 Sup 7, 85 2004

    055557-02-3 N-Nitrosoguvacoline 3 Sup 7, 85 2004

    030310-80-6 N-Nitrosohydroxyproline 3 17, Sup 7 1987

    085502-23-4 3-(N-Nitrosomethylamino)propionaldehyde 3 Sup 7, 85 2004

    060153-49-3 3-(N-Nitrosomethylamino)propionitrile 2B Sup 7, 85 2004

    010595-95-6 N-Nitrosomethylethylamine 2B 17, Sup 7 1987

    004549-40-0 N-Nitrosomethylvinylamine 2B 17, Sup 7 1987

    000059-89-2 N-Nitrosomorpholine 2B 17, Sup 7 1987

    016543-55-8064091-91-4

    N'-Nitrosonornicotine (NNN) and 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK)(NB: Overall evaluation upgraded to Group 1 based onmechanistic and other relevant data)

    1 Sup 7, 89,100E

    2012

    000100-75-4 N-Nitrosopiperidine 2B 17, Sup 7 1987

    007519-36-0 N-Nitrosoproline 3 17, Sup 7 1987

    000930-55-2 N-Nitrosopyrrolidine 2B 17, Sup 7 1987

    013256-22-9 N-Nitrososarcosine 2B 17, Sup 7 1987

    000088-72-2 2-Nitrotoluene

    (NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 101 2013

    000099-08-1

    000099-99-0

    Nitrotoluenes 3 65 1996

    000099-55-8 5-Nitro-ortho-toluidine 3 48 1990

    000804-36-4 Nitrovin 3 31, Sup 7 1987

    118399-22-7 Nodularins 3 94 2010

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    CAS No Agent Group Volume Year

    Non-arsenical insecticides (occupational exposures inspraying and application of)

    2A 53 1991

    025038-54-4 Nylon 6 3 19, Sup 7 1987

    000303-47-9 Ochratoxin A 2B Sup 7, 56 1993

    022966-79-6 Oestradiol mustard 3 9, Sup 7 1987

    Oestrogen (see Estrogen)

    002646-17-5 Oil Orange SS 2B 8, Sup 7 1987

    Opisthorchis felineus(infection with) 3 61 1994

    Opisthorchis viverrini(infection with) 1 61, 100B 2012

    Oral contraceptives, combined estrogen-progestogen(see Estrogen-progestogen oral contraceptives)

    000523-44-4 Orange I (see CI Acid Orange 20)

    001936-15-8 Orange G (see CI Orange G)

    Outdoor air pollution 1 109 in prep

    Outdoor air pollution, particulate matter in 1 109 in prep

    000604-75-1 Oxazepam 2B Sup 7, 66 1996

    000129-20-4 Oxyphenbutazone 3 13, Sup 7 1987

    Painter (occupational exposure as a) 1 47, 98, 100F 2012

    Paint manufacture (occupational exposure in) 3 47 1989

    012174-11-7 Palygorskite (Attapulgite) (long fibres, > 5 micrometres) 2B 68 1997

    012174-11-7 Palygorskite (Attapulgite)(short fibres, < 5 micrometres) 3 68 1997

    000794-93-4 Panfuran S (containing dihydroxymethylfuratrizine) 2B 24, Sup 7 1987000103-90-2 Paracetamol (Acetaminophen) 3 50, 73 1999

    010048-32-5 Parasorbic acid 3 10, Sup 7 1987

    000056-38-2 Parathion 3 30, Sup 7 1987

    Particulate matter in outdoor air pollution (see Outdoor airpollution, particulate matter in)

    000149-29-1 Patulin 3 40, Sup 7 1987

    Paving and roofing with coal-tar pitch (see Coal-tar pitch) 35, Sup 7,92, 100F

    2010

    000090-65-3 Penicillic acid 3 10, Sup 7 1987

    057465-28-8 3,4,5,3,4-Pentachlorobiphenyl (PCB-126)(see Polychlorinated biphenyls, dioxin-like, with a TEFaccording to WHO)

    1 100F 2012

    057117-31-4 2,3,4,7,8-Pentachlorodibenzofuran(NB: Overall evaluation upgraded to Group 1 based onmechanistic and other relevant data)

    1 100F 2012

    000076-01-7 Pentachloroethane 3 41, Sup 7, 71 1999

    000087-86-5 Pentachlorophenol (see Polychlorophenols) 53, 71 1999

    037319-17-8 Pentosan polysulfate sodium 2B 108 in prep

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    CAS No Agent Group Volume Year

    000335-67-1 Perfluorooctanoic acid 2B 110 in prep

    052645-53-1 Permethrin 3 53 1991

    000198-55-0 Perylene 3 Sup 7, 92 2010

    060102-37-6 Petasitenine 3 31, Sup 7 1987

    Petroleum refining (occupational exposures in) 2A 45 1989

    Petroleum solvents 3 47 1989

    Pickled vegetables (traditional in Asia) 2B 56 1993

    000062-44-2 Phenacetin(NB: Overall evaluation upgraded to Group 1 withsupporting evidence from other relevant data)

    1 24, Sup 7,100A

    2012

    Phenacetin, analgesic mixtures containing 1 Sup 7, 100A 2012

    000085-01-8 Phenanthrene 3 Sup 7, 92 2010

    000136-40-3 Phenazopyridine hydrochloride 2B 24, Sup 7 1987

    000156-51-4 Phenelzine sulfate 3 24, Sup 7 1987

    000103-03-7 Phenicarbazide 3 12, Sup 7 1987

    000050-06-6 Phenobarbital 2B Sup 7, 79 2001

    000108-95-2 Phenol 3 47, 71 1999

    000077-09-8 Phenolphthalein 2B 76 2000

    000063-92-3 Phenoxybenzamine hydrochloride 2B 24, Sup 7 1987

    000050-33-9 Phenylbutazone 3 13, Sup 7 1987

    000108-45-2 meta-Phenylenediamine 3 16, Sup 7 1987

    000106-50-3 para-Phenylenediamine 3 16, Sup 7 1987000122-60-1 Phenyl glycidyl ether 2B 47, 71 1999

    000135-88-6 N-Phenyl-2-naphthylamine 3 16, Sup 7 1987

    000090-43-7 ortho-Phenylphenol 3 73 1999

    000057-41-0 Phenytoin 2B Sup 7, 66 1996

    105650-23-5 PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) 2B 56 1993

    014596-37-3 Phosphorus-32, as phosphate 1 78, 100D 2012

    000213-46-7 Picene 3 92 2010

    001918-02-1 Picloram 3 53 1991

    111025-46-8 Pioglitazone 2A 108 in prep

    000051-03-6 Piperonyl butoxide 3 30, Sup 7 1987007440-07-5 Plutonium 1 78, 100D 2012

    053973-98-1 Poligeenan (see Carrageenan, degraded)

    009003-01-4 Polyacrylic acid 3 19, Sup 7 1987

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    CAS No Agent Group Volume Year

    059536-65-1 Polybrominated biphenyls(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data, namelymechanistic similarity with polychlorinated biphenylsclassified in Group 1)

    2A 41, Sup 7,107

    in prep

    001336-36-3 Polychlorinated biphenyls 1 18, Sup 7,107

    in prep

    Polychlorinated biphenyls, dioxin-like, with a ToxicityEquivalency Factor (TEF) according to WHO (PCBs 77,81, 105, 114, 118, 123, 126, 156, 157, 167, 169, 189)(NB: Overall evaluation upgraded to Group 1 withstrong supporting evidence from other relevant data)

    1 107 in prep

    Polychlorinated dibenzo-para-dioxins (other than 2,3,7,8-tetrachlorodibenzo-para-dioxin)

    3 69 1997

    Polychlorinated dibenzofurans(see 2,3,4,7,8-Pentachlorodibenzofuran)

    3 69 1997

    Polychlorophenols and their sodium salts (mixedexposures)

    2B 53, 71 1999

    009010-98-4 Polychloroprene 3 19, Sup 7 1987

    009002-88-4 Polyethylene 3 19, Sup 7 1987

    009016-87-9 Polymethylene polyphenyl isocyanate 3 19, Sup 7 1987

    009011-14-7 Polymethyl methacrylate 3 19, Sup 7 1987

    009003-07-0 Polypropylene 3 19, Sup 7 1987

    009003-53-6 Polystyrene 3 19, Sup 7 1987009002-84-0 Polytetrafluoroethylene 3 19, Sup 7 1987

    009009-54-5 Polyurethane foams 3 19, Sup 7 1987

    009003-20-7 Polyvinyl acetate 3 19, Sup 7 1987

    009002-89-5 Polyvinyl alcohol 3 19, Sup 7 1987

    009002-86-2 Polyvinyl chloride 3 19, Sup 7 1987

    009003-39-8 Polyvinyl pyrrolidone 3 19, Sup 7, 71 1987

    003564-09-8 Ponceau 3R 2B 8, Sup 7 1987

    003761-53-3 Ponceau MX 2B 8, Sup 7 1987

    004548-53-2 Ponceau SX 3 8, Sup 7 1987

    023746-34-1 Potassium bis(2-hydroxyethyl)dithiocarbamate 3 12, Sup 7 1987007758-01-2 Potassium bromate 2B Sup 7, 73 1999

    002955-38-6 Prazepam 3 66 1996

    029069-24-7 Prednimustine 3 50 1990

    000053-03-2 Prednisone 3 26, Sup 7 1987

    000125-33-7 Primidone 2B 108 in prep

    Printing inks 3 65 1996

    Printing processes (occupational exposures in) 2B 65 1996

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    CAS No Agent Group Volume Year

    000366-70-1 Procarbazine hydrochloride(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 26, Sup 7 1987

    Proflavine salts 3 24, Sup 7 1987

    Progestins 2B Sup 7 1987

    Progestogen-only contraceptives 2B 72 1999

    000051-02-5 Pronetalol hydrochloride 3 13, Sup 7 1987

    001120-71-4 1,3-Propane sultone(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 4, Sup 7, 71,110

    in prep

    000122-42-9 Propham 3 12, Sup 7 1987

    000057-57-8 beta-Propiolactone 2B 4, Sup 7, 71 1999000627-12-3 n-Propyl carbamate 3 12, Sup 7 1987

    000115-07-1 Propylene 3 Sup 7, 60 1994

    000075-56-9 Propylene oxide 2B Sup 7, 60 1994

    000051-52-5 Propylthiouracil 2B Sup 7, 79 2001

    087625-62-5 Ptaquiloside 3 40, Sup 7 1987

    000089-82-7 Pulegone 2B 108 in prep

    Pulp and paper manufacture 3 25, Sup 7 1987

    000129-00-0 Pyrene 3 Sup 7, 92 2010

    000110-86-1 Pyridine 3 77 2000

    085878-62-2 Pyrido[3,4-c]psoralen 3 40, Sup 7 1987

    000058-14-0 Pyrimethamine 3 13, Sup 7 1987

    000117-39-5 Quercetin 3 Sup 7, 73 1999

    000106-51-4 para-Quinone 3 15, Sup 7, 71 1999

    000082-68-8 Quintozene (Pentachloronitrobenzene) 3 5, Sup 7 1987

    Radiofrequency electromagnetic fields1 2B 102 2013

    Radioiodines, including iodine-131 1 78, 100D 2012

    Radionuclides, alpha-particle-emitting, internallydeposited(NB: Specific radionuclides for which there is sufficientevidencein humans are also listed individually as

    Group 1 agents)

    1 78, 100D 2012

    Radionuclides, beta-particle-emitting, internally deposited(NB: Specific radionuclides for which there is sufficientevidencein humans are also listed individually asGroup 1 agents)

    1 78, 100D 2012

    013233-32-4 Radium-224 and its decay products 1 78, 100D 2012

    013982-63-3 Radium-226 and its decay products 1 78, 100D 2012

    015262-20-1 Radium-228 and its decay products 1 78, 100D 2012

    010043-92-2 Radon-222 and its decay products 1 43, 78, 100D 2012

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    CAS No Agent Group Volume Year

    Refractory ceramic fibres 2B 43, 81 2002

    000050-55-5 Reserpine 3 24, Sup 7 1987

    000108-46-3 Resorcinol 3 15, Sup 7, 71 1999

    000480-54-6 Retrorsine 3 10, Sup 7 1987

    000081-88-9 Rhodamine B 3 16, Sup 7 1987

    000989-38-8 Rhodamine 6G 3 16, Sup 7 1987

    023246-96-0 Riddelliine 2B 10, Sup 7, 82 2002

    013292-46-1 Rifampicin 3 24, Sup 7 1987

    026308-28-1 Ripazepam 3 66 1996

    122320-73-4 Rosiglitazone 3 108 in prep

    Rubber manufacturing industry 1 28, Sup 7,100F

    2012

    023537-16-8 Rugulosin 3 40, Sup 7 1987

    Rock (stone) wool 3 43, 81 2002

    008047-67-4 Saccharated iron oxide 3 2, Sup 7 1987

    000081-07-2 Saccharin and its salts(NB: Overall evaluation downgraded to Group 3 withsupporting evidence from other relevant data)

    3 Sup 7, 73 1999

    000094-59-7 Safrole 2B 10, Sup 7 1987

    Salted fish, Chinese-style 1 56, 100E 2012

    000085-83-6 Scarlet Red 3 8, Sup 7 1987

    Schistosoma haematobium(infection with) 1 61, 100B 2012Schistosoma japonicum(infection with) 2B 61 1994

    Schistosoma mansoni(infection with) 3 61 1994

    007782-49-2 Selenium and selenium compounds 3 9, Sup 7 1987

    000563-41-7 Semicarbazide hydrochloride 3 12, Sup 7 1987

    013909-09-6 Semustine [1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea, Methyl-CCNU]

    1 Sup 7, 100A 2012

    000480-81-9 Seneciphylline 3 10, Sup 7 1987

    002318-18-5 Senkirkine 3 31, Sup 7 1987

    015501-74-3 Sepiolite 3 Sup 7, 68 1997

    068308-34-9 Shale oils 1 35, Sup 7,100F

    2012

    Shiftwork that involves circadian disruption 2A 98 2010

    000138-59-0 Shikimic acid 3 40, Sup 7 1987

    007631-86-9 Silica, amorphous 3 Sup 7, 68 1997

    014808-60-7 Silica dust, crystalline, in the form of quartz or cristobalite 1 Sup 7, 68,100C

    2012

    308076-74-6 Silicon carbide, fibrous 2B 111 In prep

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    CAS No Agent Group Volume Year

    409-21-2 Silicon carbide whiskers 2A 111 In prep

    000122-34-9 Simazine 3 53, 73 1999

    308068-56-6 Single-walled carbon nanotubes 3 111 In prep

    Slag wool 3 43, 81 2002

    007758-19-2 Sodium chlorite 3 52 1991

    000148-18-5 Sodium diethyldithiocarbamate 3 12, Sup 7 1987

    000132-27-4 Sodium ortho-phenylphenate 2B Sup 7, 73 1999

    Solar radiation 1 55, 100D 2012

    Soot (as found in occupational exposure of chimneysweeps)

    1 35, Sup 7,92, 100F

    2012

    Special-purpose fibres such as E-glass and '475' glass

    fibres

    2B 81 2002

    000052-01-7 Spironolactone 3 Sup 7, 79 2001

    010048-13-2 Sterigmatocystin 2B 10, Sup 7 1987

    018883-66-4 Streptozotocin 2B 17, Sup 7 1987

    Stress (see Volume 100)

    007664-93-9 Strong-inorganic-acid mists containing sulfuric acid (seeAcid mists)

    010098-97-2 Strontium-90 (see Fission products)

    000100-42-5 Styrene 2B 60, 82 2002

    009003-54-7 Styrene-acrylonitrile copolymers 3 19, Sup .7 1987

    009003-55-8 Styrene-butadiene copolymers 3 19, Sup 7 1987000096-09-3 Styrene-7,8-oxide

    (NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A Sup 7, 60 1994

    000108-30-5 Succinic anhydride 3 15, Sup 7 1987

    000842-07-9 Sudan I 3 8, Sup 7 1987

    003118-97-6 Sudan II 3 8, Sup 7 1987

    000085-86-9 Sudan III 3 8, Sup 7 1987

    006416-57-5 Sudan Brown RR 3 8, Sup 7 1987

    006368-72-5 Sudan Red 7B 3 8, Sup 7 1987

    000127-69-5 Sulfafurazole (Sulfisoxazole) 3 24, Sup 7 1987

    000095-06-7 Sulfallate 2B 30, Sup 7 1987

    000057-68-1 Sulfamethazine(NB: Overall evaluation downgraded to Group 3 withsupporting evidence from other relevant data)

    3 79 2001

    000723-46-6 Sulfamethoxazole 3 Sup 7, 79 2001

    000599-79-1 Sulfasalazine 2B 108 in prep

    Sulfites 3 54 1992

    007446-09-5 Sulfur dioxide 3 54 1992

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    CAS No Agent Group Volume Year

    000505-60-2 Sulfur mustard 1 9, Sup 7,100F

    2012

    Sunlamps and sunbeds (see Ultraviolet-emitting tanningdevices)

    002783-94-0 Sunset Yellow FCF 3 8, Sup 7 1987

    Surgical implants and other foreign bodies:- Polymeric implants prepared as thin smooth film (withthe exception of poly(glycolic acid))- Metallic implants prepared as thin smooth films- Implanted foreign bodies of metallic cobalt, metallicnickel and an alloy powder containing 66-67% nickel,13-16% chromium and 7% iron

    2B 74 1999

    Surgical implants and other foreign bodies:- Organic polymeric materials (as a group)- Orthopaedic implants of complex composition- Cardiac pacemakers- Silicone breast implants- Implanted foreign bodies of metallic chromium ortitanium and of cobalt-based, chromium-based andtitanium-based alloys, stainless steel and depleteduranium- Dental materials- Ceramic implants

    3 74 1999

    SV40 polyomavirus 3 104 2013

    022571-95-5 Symphytine 3 31, Sup 7 1987

    014807-96-6 Talc containing asbestiform fibres (see Asbestos) 42, Sup 7 1987

    014807-96-6 Talc not containing asbestos or asbestiform fibres 3 42, Sup 7, 93 2010

    014807-96-6 Talc-based body powder (perineal use of) 2B 93 2010

    010540-29-1 Tamoxifen(NB: There is also conclusive evidence that tamoxifenreduces the risk of contralateral breast cancer in breastcancer patients)

    1 66, 100A 2012

    001401-55-4 Tannic acid and tannins 3 10, Sup 7 1987

    Tea 3 51 1991

    000846-50-4 Temazepam 3 66 1996

    029767-20-2 Teniposide(NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 76 2000

    008001-50-1 Terpene polychlorinates (Strobane) 3 5, Sup 7 1987

    015721-02-5 2,2',5,5'-Tetrachlorobenzidine 3 27, Sup 7 1987

    001746-01-6 2,3,7,8-Tetrachlorodibenzo-para-dioxin 1 Sup 7, 69,100F

    2012

    000630-20-6 1,1,1,2-Tetrachloroethane 2B 41, Sup 7,71, 106

    2014

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    CAS No Agent Group Volume Year

    000079-34-5 1,1,2,2-Tetrachloroethane 2B 20, Sup 7,71, 106

    2014

    000127-18-4 Tetrachloroethylene (Perchloroethylene) 2A Sup 7, 63,106

    2014

    022248-79-9 Tetrachlorvinphos 3 30, Sup 7 1987

    000116-14-3 Tetrafluoroethylene(NB: Overall evaluation upgraded to Group 2A)

    2A 19, Sup 7,71, 110

    in prep

    Tetrakis(hydroxymethyl)phosphonium salts 3 48, 71 1999

    000509-14-8 Tetranitromethane 2B 65 1996

    Textile manufacturing industry (work in) 2B 48 1990

    000083-67-0 Theobromine 3 51 1991

    000058-55-9 Theophylline 3 51 1991000062-55-5 Thioacetamide 2B 7, Sup 7 1987

    000139-65-1 4,4'-Thiodianiline 2B 27, Sup 7 1987

    000052-24-4 Thiotepa 1 Sup 7, 50,100A

    2012

    000141-90-2 Thiouracil 2B Sup 7, 79 2001

    000062-56-6 Thiourea 3 Sup 7, 79 2001

    000137-26-8 Thiram 3 Sup 7, 53 1991

    007440-29-1 Thorium-232 and its decay products 1 78, 100D 2012

    013463-67-7 Titanium dioxide 2B 47, 93 2010

    Tobacco, smokeless 1 Sup 7, 89,100E

    2012

    Tobacco smoke, second-hand 1 83, 100E 2012

    Tobacco smoking 1 83, 100E 2012

    000108-88-3 Toluene 3 47, 71 1999

    026471-62-5 Toluene diisocyanates 2B 39, Sup 7, 71 1999

    000095-53-4 ortho-Toluidine 1 Sup 7, 77,99, 100F

    2012

    089778-26-7 Toremifene 3 66 1996

    008001-35-2 Toxaphene (Polychlorinated camphenes) 2B Sup 7, 79 2001

    Toxins derived from certain Fusariumspecies (see

    Fusarium)000299-75-2 Treosulfan 1 26, Sup 7,

    100A2012

    000396-01-0 Triamterene 2B 108 in prep

    021259-20-1 T2-Trichothecene 3 31, Sup 7 1987

    000052-68-6 Trichlorfon 3 30, Sup 7 1987

    000817-09-4 Trichlormethine (Trimustine hydrochloride) 2B Sup 7, 50 1990

    000076-03-9 Trichloroacetic acid 2B 63, 84, 106 2014

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    CAS No Agent Group Volume Year

    000545-06-2 Trichloroacetonitrile 3 52, 71 1999

    000071-55-6 1,1,1-Trichloroethane 3 20, Sup 7, 71 1999

    000079-00-5 1,1,2-Trichloroethane 3 52, 71 1999

    000079-01-6 Trichloroethylene 1 Sup 7, 63,106

    2014

    000096-18-4 1,2,3-Trichloropropane 2A 63 1995

    000102-71-6 Triethanolamine 3 77 2000

    001954-28-5 Triethylene glycol diglycidyl ether 3 11, Sup 7, 71 1999

    001582-09-8 Trifluralin 3 53 1991

    090370-29-9 4,4',6-Trimethylangelicin plus ultraviolet A radiation 3 Sup 7 1987

    000137-17-7 2,4,5-Trimethylaniline 3 27, Sup 7 1987

    000088-05-1 2,4,6-Trimethylaniline 3 27, Sup 7 1987

    003902-71-4 4,5',8-Trimethylpsoralen 3 40, Sup 7 1987

    000118-96-7 2,4,6-Trinitrotoluene 3 65 1996

    000217-59-4 Triphenylene 3 Sup 7, 92 2010

    000068-76-8 Tris(aziridinyl)-para-benzoquinone (Triaziquone) 3 9, Sup 7 1987

    000545-55-1 Tris(1-aziridinyl)phosphine oxide 3 9, Sup 7 1987

    000051-18-3 2,4,6-Tris(1-aziridinyl)-s-triazine 3 9, Sup 7 1987

    000115-96-8 Tris(2-chloroethyl) phosphate 3 48, 71 1999

    038571-73-2 1,2,3-Tris(chloromethoxy)propane 3 15, Sup 7, 71 1999

    000126-72-7 Tris(2,3-dibromopropyl) phosphate

    (NB: Overall evaluation upgraded to Group 2A withsupporting evidence from other relevant data)

    2A 20, Sup 7, 71 1999

    000057-39-6 Tris(2-methyl-1-aziridinyl)phosphine oxide 3 9, Sup 7 1987

    062450-06-0 Trp-P-1 (3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole) 2B 31, Sup 7 1987

    062450-07-1 Trp-P-2 (3-Amino-1-methyl-5H-pyrido[4,3-b]indole) 2B 31, Sup 7 1987

    000072-57-1 Trypan blue 2B 8, Sup 7 1987

    012070-12-1

    007440-48-4

    Tungsten carbide with cobalt metal (see Cobalt metalwith tungsten carbide)

    Ultraviolet radiation (wavelengths 100-400 nm,encompassing UVA, UVB, and UVC)

    1 55, 100D 2012

    Ultraviolet-emitting tanning devices 1 100D 2012

    000066-75-1 Uracil mustard 2B 9, Sup 7 1987

    Urethane (see Ethyl carbamate)

    001314-62-1 Vanadium pentoxide 2B 86 2006

    000128-66-5 Vat Yellow 4 3 48 1990

    000143-67-9 Vinblastine sulfate 3 26, Sup 7 1987

    002068-78-2 Vincristine sulfate 3 26, Sup 7 1987

    000108-05-4 Vinyl acetate 2B Sup 7, 63 1995

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    CAS No Agent Group Volume Year

    000593-60-2 Vinyl bromide(NB: (1) Overall evaluation upgraded to Group 2Abased on mechanistic and other relevant data;(2) For practical purposes, vinyl bromide should beconsidered to act similarly to the human carcinogenvinyl chloride.)

    2A 39, Sup 7,71, 97

    2008

    000075-01-4 Vinyl chloride 1 Sup 7, 97,100F

    2012

    009003-22-9 Vinyl chloride-vinyl acetate copolymers 3 19, Sup 7 1987

    000100-40-3 4-Vinylcyclohexene 2B Sup 7, 60 1994

    000106-87-6 4-Vinylcyclohexene diepoxide 2B Sup 7, 60 1994

    000075-02-5 Vinyl fluoride

    (NB: (1) Overall evaluation upgraded to Group 2Abased on mechanistic and other relevant data;(2) For practical purposes, vinyl fluoride should beconsidered to act similarly to the human carcinogenvinyl chloride.)

    2A Sup 7, 63, 97 2008

    000075-35-4 Vinylidene chloride 3 39, Sup 7, 71 1999

    009011-06-7 Vinylidene chloride-vinyl chloride copolymers 3 19, Sup 7 1987

    000075-38-7 Vinylidene fluoride 3 39, Sup 7, 71 1999

    000088-12-0 N-Vinyl-2-pyrrolidone 3 19, Sup 7, 71 1999

    025013-15-4 Vinyl toluene 3 60 1994

    012001-79-5 Vitamin K substances 3 76 2000

    Welding fumes(NB: Volume 100D concluded that there is sufficientevidencefor ocular melanoma in welders)

    2B 49 1990

    013983-17-0 Wollastonite 3 Sup 7, 68 1997

    Wood dust 1 62, 100C 2012

    Wood smoke (see Biomass fuel, indoor emissions fromhousehold combustion)

    X- and Gamma-Radiation 1 75, 100D 2012

    001330-20-7 Xylenes 3 47, 71 1999

    000095-68-1 2,4-Xylidine 3 16, Sup 7 1987

    000095-78-3 2,5-Xylidine 3 16, Sup 7 1987

    000085-84-7 Yellow AB 3 8, Sup 7 1987

    000131-79-3 Yellow OB 3 8, Sup 7 1987

    007481-89-2 Zalcitabine 2B 76 2000

    000315-18-4 Zectran 3 12, Sup 7 1987

    001318-02-1 Zeolites other than erionite (clinoptilolite,phillipsite,mordenite, non-fibrous Japanese zeolite,synthetic zeolites)

    3 68 1997

    030516-87-1 Zidovudine (AZT) 2B 76 2000

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    CAS No Agent Group Volume Year

    012122-67-7 Zineb 3 12, Sup 7 1987

    000137-30-4 Ziram 3 Sup 7, 53 1991

    1Includes radiofrequency electromagnetic fields from wireless phones

    Last update: 17 October 2014