Adverse  Events  Following  Immuniza6on  Repor&ng  standardiza&on,  automa&c  case  classifica&on  

 and  signal  detec&on      

Mélanie  Courtot,  Ryan  R.  Brinkman  and  Alan  Ru>enberg  

h8p://purl.obolibrary.org/aero  

Goal:      Increase  the  6meliness  and  cost  effec6veness  of                      reliable  adverse  event  signal  detec6on  

Problem:  Lack  of  standards  for  adverse  events  repor6ng                          limits  ability  to  query  and  assess  safety  issues  

ADVERSE  EVENTS  REPORTS  

h8p://purl.obolibrary.org/aero  

MANUAL  REVIEW  

   Solu&on:    1.   Translate  exis6ng  paper-­‐based  case  defini6ons  into  a  computer  

amenable  format,  the  Adverse  Event  Repor6ng  Ontology,  AERO  2.   Apply  AERO  to  current  repor6ng  systems  data    

h8p://purl.obolibrary.org/aero  

Automated    classifica6on  

Signal  Detec6on  

Detect  reliable  safety  signal  Faster,  cheaper  

Policy  Makers  Curators  

ADVERSE  EVENTS  REPORTS