ifc/ editorial board

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EXPERIMENTAL CELL RESEARCH Editor-in-Chief Urban Lendahl Department of Cell and Molecular Biology, Medical Nobel Institute von Eulers väg 3, Karolinska Institute, S-171 77 Stockholm, Sweden Jiri Bartek Danish Cancer Society Renato Baserga Thomas Jefferson University Sangeeta N. Bhatia Massachusetts Institute of Technology Helen M. Blau Stanford University Judith Campisi Lawrence Berkeley National Laboratory Ye-Guang Chen Tsinghua University Lena Claesson-Welsh Uppsala University Hans Clevers University Medical Center Utrecht Paolo Comoglio University of Torino Medical School John A. Cooper Washington University School of Medicine Pier-Paolo Difiore Istituto FIRC di Oncologia Moleculare Gideon Dreyfuss University of Pennsylvania School of Medicine William C. Earnshaw University of Edinburgh Reinhard Fässler Max Planck Institut für Biochemie Giulio Gabbiani Universite de Geneve Benjamin Geiger The Weizmann Institute of Science Holger Gerhardt Cancer Research UK Michael E. Greenberg Harvard Medical School Frederick Grinnell University of Texas Southwestern Medical Center Nobutaka Hirokawa University of Tokyo Jan H. J. Hoeijmakers Erasmus Universiteit Donald Ingber Harvard University Katherine A. Jones The Salk Institute for Biological Studies Guido Kroemer Institute Gustave-Roussy David P. Lane University of Dundee Lester F. Lau University of Illinois at Chicago Christian Lehner Universit¨at Zürich, Switzerland Ronald Li University of Hong Kong Benjamin L. Margolis University of Michigan Wouter H. Moolenaar The Netherlands Cancer Institute Shigekazu Nagata University of Kyoto Keiko Nakayama Tohoko University School of Medicine Claus Nerlov University of Edinburgh Eisuke Nishida Kyoto University Shin-ichi Nishikawa RIKEN Center for Developmental Biology Moshe Oren Weizmann Institute of Science Erkki Ruoslahti The Burnham Institute Paolo Sassone-Corsi University of California, Irvine Timm Schroeder Helmholtz Zentrum München John M. Sedivy Brown University Manuel Serrano Centro Nacional de Biotechnologie, CSIC Yongfeng Shang Peking University Health Sciences Center Gary S. Stein University of Massachusetts Medical Center Hermann Steller The Rockefeller University Harald Stenmark University of Oslo George Studzinski UMDNJ —New Jersey Medical School Shahragim Tajbakhsh Pasteur Institute Linda Van Aelst Cold Spring Harbor Laboratory Erwin F. Wagner Research Institute for Molecular Pathology,Vienna Boris Zhivotovsky Karolinska Institute Founding Editors: T. Caspersson and J. Runnström Editorial Offices: Karolinska Institutet, CMB, von Eulers väg 3, 17177 Experimental Cell Research, U.S. Editorial Office, 525 B Street, Suite Stockholm, Sweden; Tel. Nat.: 08-34 04 53; Int.: +46 8-34 04 53; 1800, San Diego, California 92101-4495; Tel. (619) 699-6793; E-mail: Telefax: +46 8-34 54 29; E-mail: [email protected] [email protected] Associate Editor Katherine A. Jones Regulatory Biology Laboratory, The Salk Institute for Biological Studies, P.O. Box 85800, San Diego, CA 92186-5800, USA Editors Associate Editor Christer Höög Department of Cell and Molecular Biology, Medical Nobel Institute Nobels väg 3, Karolinska Institute, S-171 77 Stockholm, Sweden Cover Legend: The cover shows a collection of images from this issue demonstrating how novel experimental models, live cell labeling techniques, high resolution imaging and computational analyses can be applied to the investigation of cell motility and mechanics at many scales within 3-D ECMs.

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EXPERIMENTAL CELL RESEARCHEditor-in-Chief

Urban Lendahl

Department of Cell and Molecular Biology, Medical Nobel Institutevon Eulers väg 3, Karolinska Institute, S-171 77 Stockholm, Sweden

Jiri BartekDanish Cancer Society

Renato BasergaThomas Jefferson University

Sangeeta N. BhatiaMassachusetts Institute of Technology

Helen M. BlauStanford University

Judith CampisiLawrence Berkeley National Laboratory

Ye-Guang ChenTsinghua University

Lena Claesson-WelshUppsala University

Hans CleversUniversity Medical Center Utrecht

Paolo ComoglioUniversity of Torino Medical School

John A. CooperWashington University School

of Medicine

Pier-Paolo DifioreIstituto FIRC di Oncologia Moleculare

Gideon DreyfussUniversity of Pennsylvania School of

Medicine

William C. EarnshawUniversity of Edinburgh

Reinhard FässlerMax Planck Institut für Biochemie

Giulio GabbianiUniversite de Geneve

Benjamin GeigerThe Weizmann Institute of Science

Holger GerhardtCancer Research UK

Michael E. GreenbergHarvard Medical School

Frederick GrinnellUniversity of Texas Southwestern Medical

Center

Nobutaka HirokawaUniversity of Tokyo

Jan H. J. HoeijmakersErasmus Universiteit

Donald IngberHarvard University

Katherine A. JonesThe Salk Institute for Biological Studies

Guido KroemerInstitute Gustave-Roussy

David P. LaneUniversity of Dundee

Lester F. LauUniversity of Illinois at Chicago

Christian LehnerUniversitat Zürich, Switzerland

Ronald LiUniversity of Hong Kong

Benjamin L. MargolisUniversity of Michigan

Wouter H. MoolenaarThe Netherlands Cancer Institute

Shigekazu NagataUniversity of Kyoto

Keiko NakayamaTohoko University School of Medicine

Claus NerlovUniversity of Edinburgh

Eisuke NishidaKyoto University

Shin-ichi NishikawaRIKEN Center for Developmental

Biology

Moshe OrenWeizmann Institute of Science

Erkki RuoslahtiThe Burnham Institute

Paolo Sassone-CorsiUniversity of California, Irvine

Timm SchroederHelmholtz Zentrum München

John M. SedivyBrown University

Manuel SerranoCentro Nacional de Biotechnologie, CSIC

Yongfeng ShangPeking University Health Sciences Center

Gary S. SteinUniversity of Massachusetts

Medical Center

Hermann StellerThe Rockefeller University

Harald StenmarkUniversity of Oslo

George StudzinskiUMDNJ—New Jersey Medical School

Shahragim TajbakhshPasteur Institute

Linda Van AelstCold Spring Harbor Laboratory

Erwin F. WagnerResearch Institute for Molecular

Pathology,Vienna

Boris ZhivotovskyKarolinska Institute

Founding Editors: T. Caspersson and J. Runnström

Editorial Offices:Karolinska Institutet, CMB, von Eulers väg 3, 17177 Experimental Cell Research, U.S. Editorial Office, 525 B Street, SuiteStockholm, Sweden; Tel. Nat.: 08-34 04 53; Int.: +46 8-34 04 53; 1800, San Diego, California 92101-4495; Tel. (619) 699-6793; E-mail:Telefax: +46 8-34 54 29; E-mail: [email protected] [email protected]

Associate Editor

Katherine A. JonesRegulatory Biology Laboratory,

The Salk Institute for Biological Studies,P.O. Box 85800, San Diego, CA 92186-5800, USA

Editors

Associate Editor

Christer HöögDepartment of Cell and Molecular Biology, Medical Nobel Institute

Nobels väg 3, Karolinska Institute,S-171 77 Stockholm, Sweden

Cover Legend: The cover shows a collection of images from this issue demonstrating how novel experimental models, live cell labeling techniques, high resolution imaging and computational analyses can be applied to the investigation of cell motility and mechanics at many scales within 3-D ECMs.