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3/19/2014 1 IHI Expedition Antibiotic Stewardship Session 1 March 20, 2014 These presenters have nothing to disclose Diane Jacobsen, MPH Scott Flanders, MD Arjun Srinivasan, MD Expedition Coordinator 2 Kayla DeVincentis, CHES, Project Coordinator, Institute for Healthcare Improvement, currently manages web-based Expeditions and the Executive Quality Leaders Network. She began her career at IHI in the event planning department and has since contributed to the State Action on Avoidable Rehospitalizations (STAAR) Initiative, the Summer Immersion Program, and IHI’s efforts for Medicare-Medicaid enrollees. Kayla leads IHI’s Wellness Initiative and has designed numerous activities, challenges, and educational opportunities to improve the health of her fellow staff members. In addition to implementing the organization’s first employee health risk assessment, Kayla is certified in health education and program planning. Kayla is a graduate of Northeastern University in Boston, MA, where she obtained her Bachelors of Science in Health Science with a concentration in Business Administration.

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3/19/2014

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IHI ExpeditionAntibiotic Stewardship Session 1

March 20, 2014

These presenters have nothing to disclose

Diane Jacobsen, MPH

Scott Flanders, MD

Arjun Srinivasan, MD

Expedition Coordinator2

Kayla DeVincentis, CHES, Project Coordinator, Institute for Healthcare Improvement, currently manages web-based Expeditions and the Executive Quality Leaders Network. She began her career at IHI in the event planning department and has since contributed to the State Action on Avoidable Rehospitalizations (STAAR) Initiative, the Summer Immersion Program, and IHI’s efforts for Medicare-Medicaid enrollees. Kayla leads IHI’s Wellness Initiative and has designed numerous activities, challenges, and educational opportunities to improve the health of her fellow staff members. In addition to implementing the organization’s first employee health risk assessment, Kayla is certified in health education and program planning. Kayla is a graduate of Northeastern University in Boston, MA, where she obtained her Bachelors of Science in Health Science with a concentration in Business Administration.

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WebEx Quick Reference

• Welcome to today’s session!

• Please use chat to “All Participants” for questions

• For technology issues only, please chat to “Host”

• WebEx Technical Support: 866-569-3239

• Dial-in Info: Communicate / Join Teleconference (in menu)

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Select Chat recipient

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All Participants

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5

Chat Time!

What is your goal for participating in this Expedition?

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Join Passport to:

• Get unlimited access to Expeditions, two- to four-month, interactive, web-based programs designed to help front-

line teams make rapid improvements.

• Train your middle managers to effectively lead quality improvement initiatives.

. . . and much, much more for $5,000 per year!

Visit www.IHI.org/passport for details.

To enroll, call 617-301-4800 or email [email protected].

3/19/2014

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IHI Open School Courses

More than 20 online courses developed by world-renowned experts in the following topics

– Improvement Capability– Patient Safety– Person- and Family-Centered Care– Triple Aim for Populations– Quality, Cost, and Value– Leadership

More than 26 continuing education contact hours for nurses, physicians, and pharmacists. NAHQ has also approved the courses for CPHQ CE credit.Basic Certificate of Completion available upon completion of 16 foundational course.Mobile App for iPhone and iPad20% Discount on organizational subscription for Passport Members

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What is an Expedition?

ex•pe•di•tion (noun)

1. an excursion, journey, or voyage made for some specific purpose

2. the group of persons engaged in such an activity

3. promptness or speed in accomplishing something

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Expedition Support

All sessions are recorded

Materials are sent one day in advance

Listserv address for session communications: [email protected]

– To add colleagues, email us at [email protected]

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Where are you joining from?

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Expedition Director11

Diane Jacobsen, MPH, CPHQ, Director, Institute for Healthcare Improvement (IHI) is currently directing the CDC/IHI Antibiotic Stewardship Initiative, NSLIJ/IHI Reducing Sepsis Mortality Collaborative. Ms. Jacobsen served as IHI content lead and improvement advisor for the California Healthcare-Associated Infection Prevention Initiative (CHAIPI) and directed Expeditions on Antibiotic Stewardship, Preventing CA-UTIs, Reducing C.difficle Infections, Sepsis, Stroke Care and Patient Flow. She served as faculty for IHI’s 100,000 Lives and 5 Million Lives Campaign and directed improvement collaboratives on Sepsis Mortality, Patient Flow, Surgical Complications, Reducing Hospital Mortality Rates (HSMR) and co-directed IHI’s Spread Initiative. She is an epidemiologist with experience in quality improvement, risk management, and infection control in specialty, academic, and community hospitals. A graduate of the University of Wisconsin, she earned her master’s degree in Public Health- Epidemiology.

Today’s Agenda12

Ground Rules & Introductions

Pre-program Survey Results

Making the Case for Antibiotic Stewardship

Engaging Front Line Providers

IHI’s Model for Improvement

Action Period Assignment

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Ground Rules13

We learn from one another – “All teach, all learn”

Why reinvent the wheel? – Steal shamelessly

This is a transparent learning environment – Share Openly

All ideas/feedback are welcome and encouraged!

Overall Program Aim

The Expedition will provide insights from the hospitalist-led antibiotic stewardship initiative in partnership with the

Centers for Disease Control and Prevention (CDC) that incorporated specific interventions to improve antibiotic use

into the process of patient care, such as an "antibiotic timeout" to facilitate/prompt de-escalation or

discontinuation of antibiotics through review of AB, dose, indication and expected duration.

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Expedition Objectives

At the end of this Expedition, participants will be able to:

Describe the impact of overuse and misuse of antibiotics on costs of care, antimicrobial resistance and patient complications, including Clostridium difficile.

Establish a multidisciplinary focus to embed antibiotic stewardship into the process of care.

Identify and begin improving at least one key process to optimize antibiotic selection, dose, and duration of antibiotics in the patient care setting.

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Schedule of Calls

Session 1 – “Making the Case” for Antibiotic StewardshipDate: Thursday, March 20

th2:30 PM – 4:00 PM ET

Session 2 – Promoting a Culture for Optimal Antibiotic UseDate: Thursday, April 3, 3:00 – 4:00 PM ET

Session 3 – Our Learning Journey: IHI & CDC PartnershipDate: Thursday, April 17, 3:00 – 4:00 PM ET

Session 4 – Embedding Stewardship Processes into Care DeliveryDate: Thursday, May 1, 3:00 – 4:00 PM ET

Session 5 – Focus on: 72 Hour Antibiotic “Time-out”Date: Thursday, May 15, 3:00 – 4:00 PM ET

Session 6 – What Are We Testing & Learning?Date: Thursday, May 29, 3:00 – 4:00 PM ET

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Pre-Program Survey Results

Diane Jacobsen, MPH, CPHQ

Survey Results:What roles will be represented on your team participating in the Expedition?

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Survey Results: Barriers to a successful Antibiotic Stewardship Program

Lack of a Physician Champion

C suite not recognizing the impact of ASP, MDRO’s CDI

Lack of ID physicians; lack of expertise on site

Limited access to pharmacy in some clinical areas

Limited forum to communicate useful data to physicians

Staffing: Cuts, shortages, perceived time constraints

IT support; Ability to access/report useful data

Culture: “We’ll need to change a lot of mindsets”

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Survey Results: What we’re most proud of in improving Antibiotic Stewardship

Developing interest [in ABS] at the management levelCreation of a multidisciplinary team through the physician & chiefAgreed upon formulary limiting choice of appropriate ABReview of unit based prescribing data at monthly team meetingsActive role of pharmacy in monitoring & making recommendations w/input from ID specialist pharmacistBroader representation on ASP committee, including hospitalistsAudited transparency of AB use at the point of care & reviewed current status to improve processes, rather than focusing on individual treatment decisions

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Survey Results: What we’re hoping to learn about AB Stewardship

About 72 hour AB time out

How to start a stewardship program - first thing a facility should do

Ideas for eliminating barriers and engaging C suite

Better ways to engage/support front-level providers

How others have successfully overcome barriers

“Everything I need to know to pull this together successfully”

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Survey Results:Degree to which each core element is currently in place/practice

Do not know thecurrent status of

this elementin our hospital

Do no have this element in current

practice at our hospital

Have a currentprocess that

supports this element in our

hospital

This element is reliably applied

in all relevantsituations in our

hospital

Need furtherclarification on

this element

Leadership 15% 17% 56% 9% 3%

Accountability 18 38 32 6 6

Drug Expertise 18 26 35 21 0

Prescribing Improvement

15 32 38 15 0

Track AB Use 18 26 38 15 3

Report Rx and Resistance

27 35 29 6 3

Educate 18 23 50 9 0

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Survey Results:Degree to which specific interventions are currently in place/practice

Do not know the current status of

this intervention in our hospital

Do not currently have this

intervention in place at our

hospital

Have a current process that

supports this intervention in our

hospital

This intervention is reliably applied in

our hospital

Need further clarification on this

intervention

AntibioticTimeout

9% 70% 21% 0% 0%

MDRs include AB

6 62 23 9 0

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Faculty24

Arjun Srinivasan, MD, Associate Director for Healthcare Associated Infection Prevention Programs in the Division of Healthcare Quality Promotion at the Centers for Disease Control and Prevention (CDC), is responsible for oversight and coordination of efforts to eliminate health care-associated infections. He led the CDC health care outbreak investigations team and served as Medical Director for the Get Smart for Healthcare campaign, an effort to improve the use of antimicrobials in in-patient health care facilities. Previously, he was an Assistant Professor of Medicine in the Infection Diseases Division at the John Hopkins School of Medicine, where he was Associate Hospital Epidemiologist and Founding Director of the Johns Hopkins Antibiotic Management Program. Dr. Srinivasan’s research focuses on outbreak investigations, infection control, multi-drug-resistant gram-negative pathogens, and antimicrobial use. He has published more than 70 articles in peer-reviewed journals and is a member of the Association for Professionals in Infection Control and Epidemiology, the Infectious Diseases Society of America, and the Society for Healthcare Epidemiology of America.

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Faculty25

Scott A. Flanders, MD, MHM, is a Professor in the Division of General Internal Medicine at the University of Michigan, where he serves as Associate Division Chief of General Medicine for Inpatient Programs and Associate Director of Inpatient Programs for the Department of Internal Medicine. Dr. Flanders was a founding member of the Board of Directors of the Society of Hospital Medicine (SHM) and is a Past-President of SHM. In addition to these activities, Dr. Flanders has been active in quality improvement and patient safety at the University of Michigan. His research interests include hospitalists, hospital-acquired conditions and their prevention, dissemination of patient safety and quality improvement practices, and the diagnosis and treatment of lower respiratory infections.

Faculty26

Lori A. ‘Loria’ Pollack, MD is a U.S. Public Health Service Medical Officer in the Division of Healthcare Quality Promotion (DHQP) at Centers for Disease Control and Prevention (CDC) in Atlanta, GA. Dr. Pollack received degrees in medicine and public health (MD, MPH) from UMDNJ-Robert Wood Johnson Medical School in 1999 and completed an internal medicine residency at Columbia University’s primary care program in Cooperstown, NY. She joined CDC in 2002 as an Epidemic Intelligence Service Officer. Dr. Pollack was an epidemiologist in the Division of Cancer Prevention and Control where she led national efforts related to cancer survivorship. After 8 years at the federal level, she transitioned to work with the medical director of the local public health department in Atlanta, Georgia where she completed a second residency in Preventive Medicine. In July 2012, Dr. Pollack returned to CDC to focus on preventing healthcare-associated illness and addressing antibiotic resistance through antimicrobial stewardship. Dr. Pollack is board-certified in Internal Medicine and Preventive Medicine. She is the author or coauthor on more than 35 papers in epidemiology and health service research. A driving theme in Dr. Pollack’s diverse public health career is the translation and dissemination of research into practical guidance and tools improve health and health care.

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Antimicrobial Stewardship-Why We MustHow We Can

CAPT Arjun Srinivasan, MD

Associate Director for Healthcare Associated

Infection Prevention Programs

Division of Healthcare Quality Promotion

Why the Imperative for Stewardship?

� Antibiotic overuse and misuse is fueling major threats to patient safety:

� Antibiotic resistance

� Clostridium difficile

� Adverse drug reactions

� When patients get antibiotics they don’t need they are exposed to totally preventable risks for bad outcomes.

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Why the Imperative for Stewardship?

� There is huge room for improvement in the way we use antibiotics.

� Recent CDC Vital Signs report showed that nearly 40% of hospital prescriptions for UTI and vancomycin were potentially inappropriate (no cultures done, given too long).

� That number is very consistent with many other studies over many years.

Why the Imperative for Stewardship?

� There is huge room for improvement in the way we use antibiotics.

� Vital Signs report also found that overall antibiotic use on medical-surgical wards at different hospitals varied by 300%.

� Even more variation in the use of some agents.

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Why the Imperative for Stewardship?

It Works!

� Published data demonstrate that improving antibiotic use can:

� Improve infection cure rates

� Reduce C. difficile rates

� Reduce antibiotic resistance

� Improve antibiotic dosing

� Save money

Recommendations for Antibiotic Stewardship Programs

� “CDC recommends that all hospitals implement an antibiotic stewardship program.”

� American Hospital Association also recommends antibiotic stewardship programs as a “Top 5” intervention for hospitals.

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How Do We Make It Happen?

� Hospitals don’t all look the same, and neither do stewardship programs.

� There must be flexibility in how programs are implemented.

� But, there are certain key elements that have been strongly associated with success.

Core Elements for Antibiotic Stewardship Programs

� Leadership commitment from administration

� Single leader responsible for outcomes

� Single pharmacy leader

� Specific improvement interventions

� Antibiotic use tracking

� Regular reporting on antibiotic use and resistance

� Educating providers on use and resistance

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Core Elements for Antibiotic Stewardship Programs

� CDC has posted details on these core elements, including some specific tips on how to implement them in:

� “Core Elements of Hospital Antibiotic Stewardship Programs”

� http://www.cdc.gov/getsmart/healthcare/implementation/core-elements.html

“Checklist”

� CDC has also developed an assessment tool or “checklist” that facilities can use to assess implementation of the core elements.

� Assessment tool can help identify areas for potential improvement.

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Some is not a number.Soon is not a time.

� We need to get specific with stewardship.

� We need all hospitals to implement antibiotic stewardship programs that incorporate the core elements that have proven to be key to success.

� We know a lot about what needs to be done and how to do it.

� We need to do it, now.

Questions?38

Raise your hand

Use the Chat

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Engaging Frontline Providers

Scott Flanders, MD

Why Frontline Providers?

Stewardship team often has limited reach

“Top-down” initiatives important, but only step 1

– Formulary restriction

– Data Monitoring

Many practices needing change are hard to spot from “behind the front”

– Treatment of asymptomatic bacteriuria

– Prolonged treatment duration

Not everyone has a stewardship program

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Who to Engage?

Groups where “culture” drives practice

– Surgical ICU

– Urology

– Orthopedic surgery, etc.

Non-physician team members

– PAs, NPs, nursing, clerical assistants

Patients

– Infection prevention (hand hygiene, device use)

– Indication, duration

HOSPITALISTS

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Why Engage Hospitalists?

In the U.S., numbers of hospitalists are growing

– > 35,000

Many hospitals have hospitalist programs

– 2/3 of U.S. hospitals (over 90% if beds > 500)

In 2006 nearly 50% of all U.S. non-surgical Medicare discharges were cared for by hospitalists

Increasingly taking the lead on QI work

– They understand systems redesign

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Hospitalists and Antimicrobial Stewardship

Antimicrobial resistance and antibiotic complications (C.difficile) hit home

Templates, guidelines and checklists are commonplace in hospital medicine

Hospitalists must tackle issues with signouts, handoffs, and care transitions

– Dr X comfortable stopping the drug Dr Y started

There often isn’t anyone else to do this?!

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What the #! Are Doctors Doing?

Antibiotic Use in U.S. Hospitals

56% of hospitalized patients received antibiotics

37% of use for urinary tract infection and Vancomycinuse could be improved

Three-fold variability in use between similar hospital wards

High variability in use for broad spectrum antibiotics

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Fridkin S, et al. MMWR, 2014

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Drivers of Escalating Use

Hospitalized patients are ill

– Co-morbid conditions

– Immunosuppressed

The revolving door of the hospital

– 25% readmitted at 30 days

– Skilled nursing facilities

– Home IV antibiotics

– Healthcare associated infections

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Drivers of Escalating Use

Discontinuities in care

– Within the hospital (ED-floor, ICU-floor)

– Within physician groups

– “Admitters / Rounders”

– Night coverage

– 5 days on, 5 days off

– Teaching hospitals: 80 hours / week, days off

– “They must have wanted the Meropenem for a good reason”

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Drivers of Escalating Use

Performance indicators

– CAP

– Antibiotics in 6 hours

– Value based purchasing (it matters!)

Early APPROPRIATE empiric antibiotics

– Improves mortality

– Sepsis, VAP, HCAP, etc.

– “Hit it hard, hit it early!”

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Current Challenges

What is not happening reliably?

Allergy assessment

Review of prior culture results / antibiograms

Antibiotic restraint

– Double anaerobic coverage

– Treatment of asymptomatic bacteriuria

– Treatment of colonizing organisms

Re-consideration of the diagnosis

Narrowing coverage at 48-72 hours

Treating for an appropriate duration

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Misperceptions

They don’t care about this stuff

They already know all this stuff and choose not to do the “right” thing

They are too busy

They do not want to be bothered

They have more important problems they are working on

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The Chagrin Factor50

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The Chagrin Factor

A physician is seeing a patient whose clinical picture and culture results could represent infection. Which outcome would a physician most like to avoid?

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The Chagrin Factor

A) Antibiotics are withheld. The patient develops sepsis, shock, and requires transfer to the ICU

B) Antibiotics are given. The patient does well, but develops a rash, and C. difficile requiring metronidazole

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Where Do We Start?

Find a frontline provider champion

Try tackling one issue with one provider

Focus on common conditions

– UTI, CAP, Skin / Soft Tissue Infections

– These 3 drive 50% of all antibiotic use

– Start with de-escalation opportunities

Think about how to build changes into processes of care

Then expand

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Driving Appropriate Use

Barriers identified in CDC/IHI Pilot Testing

Real-world issues

– Large / multiple groups make communication difficult

– Poor continuity / hand-offs

– Nurses are overwhelmed

– High patient loads

“Another !#$#% QI project?”

IT / CPOE

Time / ability to collect data

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Driving Appropriate Use

Navigating Barriers

Demonstrate the need to improve

– Even a sample of 10 charts can tell a story

Many providers like the help

Order sets / protocols help

Start small (sometimes very small)

Ask for feedback, de-brief after interventions

Share / celebrate successes

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Bottom Line

We have big problems with antibiotic use in U.S. hospitals

Drivers of use are complex

Stewardship programs are critical…..

But frontline providers are key to widespread success

Barriers to engagement are surmountable

We need to act now

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Questions?57

Raise your hand

Use the Chat

What are we trying toaccomplish?

How will we know that a

change is an improvement?

What change can we make that

will result in improvement?

Model for Improvement

Act Plan

Study Do

Aim of Improvement

Measurement of

Improvement

Developing a Change

Testing a Change

Adapted from Langley, G. J., Nolan, K. M., Nolan, T. W., Norman, C. L., & Provost, L. P. The Improvement Guide: A Practical Approach to Enhancing Organizational Performance. San Francisco, CA: Jossey-Bass, 1996.

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Plan• Compose aim

• Pose questions/predictions

• Create action plan to carry

out cycle (who, what, when,

where)

• Plan for data collection

DoStudy

Act

• Carry out the test and

collect data

• Document what occurred

• Begin analysis of data

• Complete data analysis

• Compare to predictions

• Summarize learning

• Decide changes to make

• Arrange next cycle

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Principles & Guidelines for Testing

A test of change should answer a specific question

A test of change requires a theory and prediction

Test on a small scale

Collect data over time

Build knowledge sequentially with multiple PDSA cycles for each change idea

Include a wide range of conditions in the sequence of tests

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Repeated Use of the PDSA Cycle61

Hunches Theories Ideas

Changes That Result in Improvement

A P

S D

A P

S D

Very Small Scale Test

Follow-up Tests

Wide-Scale Tests of Change

Implementation of Change

Sequential building of knowledge under a wide range of conditions Spread

Aim: Implement Rapid Response Team on non-ICU unit

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Improved Communication

A P

S D

A P

S D

Cycle 1: ICU nurse responds to rapid response team calls on one unit,

one shift for one day

Cycle 2: Repeat cycle 1 for three days

Cycle 3: Have Respiratory Therapist attend

rapid response calls with ICU Nurse

Cycle 4: Expand coverage of RRT on unit

to one unit for one shift for five days

Cycle 5: Have Nurse Practitioner

respond to calls in addition to RT and

RN

Cycle 6: Expand rounds to

one unit for one shift seven

days a week

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Questions?63

Raise your hand

Use the Chat

Action Period Assignment

Review the seven core elements and identify areas of strength and areas of opportunity. Identify one specific intervention to focus on during the

expedition

Identify a group of people/providers that you’re not currently engaging with that you will create a partnership with to support stewardship

Come prepared to share your plans at the next session

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Expedition Communications

Listserv for session communications: [email protected]

To add colleagues, email us at [email protected]

Pose questions, share resources, discuss barriers or successes

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Next Session

Thursday, April 3rd, 3:00 PM – 4:00 PM ET

Session 2 – Promoting a Culture for Optimal Antibiotic Use

Loria Pollack, MD, MPHCenters for Disease Control and Prevention

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