iion agri-food and health conference: cosmeceuticals: set up for a pharmaceutical segue - warren...

7/27/2019 IION Agri-Food and Health Conference: Cosmeceuticals: Set up for a Pharmaceutical Segue - Warren Chin

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Cosmeceuticals:

Set up for a Pharmaceutical Segue

September 21, 2013

Huntsville, ON

Moon BayBiologics Inc


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Agenda

Moon Bay Biologics: brief background

Role in Applied Institute of Mycology

Overview of An Application

Moon BayBiologics Inc


4/23

Moon Bay Biologics

Jack Hay, PhD Founder, Moon Bay Shiitake

Professor Emeritus, Dept. Immunology, University ofToronto

Jean-Marc Moncalvo, PhD Senior Curator of Mycology, Royal Ontario Museum

Associate Professor, Dept. Ecology & EvolutionaryBiology, University of Toronto

Faculty of Forestry, University of Toronto

Warren Chin, PhD, MBA ILEX Consulting Inc.

Moon Bay

Biologics Inc


5/23

Moon Bay Biologics

Acknowledgements

Rob Deline, IION

Usha Srinivasan, PhD, MaRS

Richard Worsfold, OCE Mukund Jha, PhD, Nipissing University

Xiaocui Xiao, PhD

Mary Nowak, MD

Moon Bay

Biologics Inc


6/23

Role in Applied Institute of Mycology

Applied mycology research A long-term objective

Multiple short-term objectives

Development of capacity to conduct appliedresearch Education

Training

Applied research collaborations Institute partners

Contract research

Moon Bay

Biologics Inc


7/23

Overview of an Application

Long-Term Objective: to discover new bioactivesubstances from fungi that can be patented andsold as prescription medicines

Opportunity: the pharmaceutical industry is indecline due to the patent cliff, the commercialpotential of new products are underwhelming, sopartnerships are being sought withbiotechnology companies to enhance pipelines

Challenge: substantial time and resourcesrequired to bring new compounds to market

Moon Bay

Biologics Inc


8/23

Overview of an Application

Short-Term Objective: to generate revenue thatwill fund the long-term research

Opportunity: apply our scientific research

capabilities in less regulated industries todevelop commercially viable products

Challenge: select an area of focus

Utilize our scientific research expertise

Provide value for customers

Financially lucrative

Moon Bay

Biologics Inc


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Target Market

Anti-Aging Market

Baby boomers control over 75% of this market

200 million worldwide, growing at 38% annually

Boomer anti-aging market in 2013 valued at$274.5 billion

Three main segments: appearance, disease, fitness

Appearance segment valued at $105.4 billion with acompound annual growth rate of 10.4%

Moon Bay

Biologics Inc


11/23

Target Market

Anti-Aging Market

The goal of the anti-aging appearance market isto help people retain and restore beauty, look

young and improve quality-of-life Baby boomers have high disposable income

Anti-aging products attract premium pricing in

comparison to conventional cosmetic products

Moon Bay

Biologics Inc


12/23

Customer Needs

Aging involves a series of biochemical changesin the body due to internal and external factors

Chronic exposure to solar radiation is the most

important factor in the initiation of skin disorderssuch as wrinkling, scaling, dryness, mottled skinpigmentation and skin cancer

Individuals can use skin care products to preventand reverse photo damaging effects in the skin

Moon Bay

Biologics Inc


13/23

Customer Needs

Photo damage involves oxidative damage due tothe generation of free radicals

Many cosmetic products include antioxidants

Growth of 12.7% in 2011

Health concerns about harmful chemicals

Cosmetic products not regulated by FDA

Some sunscreen ingredients may become freeradicals when activated by UV radiation

Market has seen an increase in all-natural or organicproducts

Moon Bay

Biologics Inc


14/23

Customer Needs

Characteristics of ideal anti-aging skin product

Protect against solar radiation damage

High antioxidant content

Natural product Safe, non-toxic

Backed by scientific research

Moon Bay

Biologics Inc


15/23

Science

Research into the impact of solar radiation onthe skin has traditionally focused on ultravioletradiation (UV-A, UV-B, UV-C)

Sunscreen is designed to filter or block UVradiation

Moon Bay

Biologics Inc


16/23

Science

UV radiation constitutes 7% of solar radiation

39% of solar radiation is in the visible range

54% of solar radiation is in the infrared (IR) range

Solar radiation protection strategies are notprovided for free radicals formed in the visibleand IR ranges

Research is now beginning to exam the impactof IR radiation on the skin

Moon Bay

Biologics Inc


17/23

Science

IR-A penetrates the dermal layer, destroyscollagen and decreases the natural antioxidantcapability of the skin

Moon Bay

Biologics Inc


18/23

Science

IR-A activates protein kinases that are importantin photo aging and carcinogenesis

The mechanism of action involves oxidative

stress and the production of free radicals Antioxidants are necessary to provide protective

effects in the IR range

Not only do antioxidants neutralize free radicals, theyalso limit damage from solar-induced inflammation

Moon Bay

Biologics Inc


19/23

Science

Moon Bay

Biologics Inc

Oxygen Radical Absorbance Capacity (ORAC) Score per 100 grams

Chaga boasts the highest antioxidant content, astested by the US Department of Agriculture
http://www.sgn80.com/blog/this-critical-enzyme-has-25-50-times-more-antioxidant-power-than-coq10-vitamin-c/orac-score-comparisons/


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Science

Moon Bay

Biologics Inc5 10 15 20 25

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File:

Channel:

Last recalc:

c:\star\varian user files\mukund jha\2011-2012\mushroom extract\frozen shi c_2_12-7-2011.run

1 = 260 nm Results

NA

X:

Y:

PeakName:

Result:

Area:

Width:

8.8057 Minutes

2.98 mAU

0.440

392609 Counts*sec

0.000 sec


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Commercial Product

Must deliver antioxidants to the dermis andsubcutaneous layer to protect against solardamage

Micellar nanoparticle (MNP) technology invented inthe mid-1990s

MNP formulations can be tailored to deliver activecompounds topically (skin is the site of action) or

transdermally (systemic availability) MNP composition is inherently antimicrobial

MNPs exhibit good safety profiles

Moon Bay

Biologics Inc


22/23

Commercial Product

Zein is a natural protein derived from corn

Polyethylene glycol (PEG) is grafted to zein to formnanomicelles

PEG-zein nanomicelles are safe and non-immunogenic

PEG-zein nanomicelles cross the epidermisand reach the lower skin layers

Moon Bay

Biologics Inc


23/23

Conclusion

Characteristics of Ideal Anti-Aging Skin Product

Offers protection against solar radiation

High antioxidant content to neutralize damage,

including IR-A Delivery to deep dermal layers

Natural product

Good safety profile Backed by scientific research

Moon Bay

Biologics Inc

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